SIMILAR PATTERNS OF AMINO ACIDS FOR 1JIP_A_KTNA801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE


(Triticum
aestivum)
PF00709
(Adenylsucc_synt)
5 GLY A  99
LEU A  78
ARG A 114
LEU A  70
ALA A  69
None
1.29A 1jipA-1dj3A:
0.0
1jipA-1dj3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 PHE A 309
GLY A 188
LEU A  53
ALA A 214
LEU A 302
None
0.98A 1jipA-1fc4A:
0.0
1jipA-1fc4A:
23.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
7 ALA A  74
GLY A  91
LEU A 175
ARG A 185
VAL A 237
ALA A 241
LEU A 391
DEB  A 420 (-3.8A)
HEM  A 410 ( 3.1A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 3.6A)
DEB  A 420 ( 4.8A)
0.51A 1jipA-1jioA:
68.9
1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
6 ALA A  74
LEU A 175
ARG A 185
ALA A 245
THR A 292
LEU A 391
DEB  A 420 (-3.8A)
None
DEB  A 420 ( 4.6A)
HEM  A 410 (-3.5A)
None
DEB  A 420 ( 4.8A)
1.26A 1jipA-1jioA:
68.9
1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
9 ALA A  74
TYR A  75
GLY A  91
THR A  92
LEU A 175
ARG A 185
VAL A 237
THR A 292
LEU A 391
DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
HEM  A 410 ( 3.1A)
DEB  A 420 (-4.2A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
None
DEB  A 420 ( 4.8A)
0.21A 1jipA-1jioA:
68.9
1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
5 ALA A  74
TYR A  75
LEU A 392
VAL A 237
LEU A 391
DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
DEB  A 420 (-3.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 4.8A)
1.29A 1jipA-1jioA:
68.9
1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
7 GLY A  91
LEU A 175
ARG A 185
VAL A 237
LEU A 240
ALA A 241
LEU A 391
HEM  A 410 ( 3.1A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 4.5A)
DEB  A 420 ( 3.6A)
DEB  A 420 ( 4.8A)
0.69A 1jipA-1jioA:
68.9
1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
6 PHE A  72
ALA A  74
LEU A 175
ARG A 185
ALA A 245
LEU A 391
None
DEB  A 420 (-3.8A)
None
DEB  A 420 ( 4.6A)
HEM  A 410 (-3.5A)
DEB  A 420 ( 4.8A)
1.29A 1jipA-1jioA:
68.9
1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
6 PHE A  72
ALA A  74
TYR A  75
LEU A 175
ARG A 185
LEU A 391
None
DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.8A)
0.75A 1jipA-1jioA:
68.9
1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
6 PHE A  72
TYR A  75
LEU A 175
ARG A 185
LEU A 240
LEU A 391
None
DEB  A 420 ( 4.8A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.5A)
DEB  A 420 ( 4.8A)
0.76A 1jipA-1jioA:
68.9
1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
8 TYR A  75
GLY A  91
THR A  92
LEU A 175
ARG A 185
VAL A 237
LEU A 240
LEU A 391
DEB  A 420 ( 4.8A)
HEM  A 410 ( 3.1A)
DEB  A 420 (-4.2A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 4.5A)
DEB  A 420 ( 4.8A)
0.43A 1jipA-1jioA:
68.9
1jipA-1jioA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE


(Pseudomonas sp.
KKS102)
PF00903
(Glyoxalase)
5 PHE B  10
ALA B  50
GLY B   6
ALA B 120
LEU B  39
None
1.19A 1jipA-1kwcB:
0.6
1jipA-1kwcB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8j ENDOTHELIAL PROTEIN
C RECEPTOR


(Homo sapiens)
PF16497
(MHC_I_3)
5 ALA A 135
LEU A 151
VAL A 118
THR A 140
LEU A 148
None
1.18A 1jipA-1l8jA:
undetectable
1jipA-1l8jA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME


(Eisenia fetida)
PF00089
(Trypsin)
5 ALA A  83
GLY A  69
THR A  80
LEU A 106
LEU A 108
None
1.19A 1jipA-1m9uA:
0.0
1jipA-1m9uA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE


(Pyrococcus
abyssi)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g)
5 PHE A 465
ALA A 463
LEU A 396
LEU A 456
LEU A 400
None
1.25A 1jipA-1rqgA:
2.2
1jipA-1rqgA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER


(Escherichia
coli)
PF00909
(Ammonium_transp)
5 ALA A 377
VAL A 116
LEU A 119
ALA A 120
LEU A 383
None
1.38A 1jipA-1u7gA:
0.5
1jipA-1u7gA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE


(Penicillium
simplicissimum)
PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C)
5 PHE A 353
THR A 457
LEU A 346
ALA A 319
LEU A 348
None
1.33A 1jipA-1w1kA:
0.0
1jipA-1w1kA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2f CELL DIVISION
PROTEIN ZIPA


(Escherichia
coli)
PF04354
(ZipA_C)
5 GLY A  40
LEU A  28
LEU A  61
ALA A  62
LEU A  29
None
None
None
WAI  A 300 (-3.5A)
None
1.12A 1jipA-1y2fA:
undetectable
1jipA-1y2fA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z87 ALPHA-1-SYNTROPHIN

(Mus musculus)
PF00595
(PDZ)
5 GLY A 263
THR A 264
LEU A  33
ALA A 255
LEU A  40
GLY  A 263 ( 0.0A)
THR  A 264 ( 0.8A)
LEU  A  33 ( 0.6A)
ALA  A 255 ( 0.0A)
LEU  A  40 ( 0.6A)
1.32A 1jipA-1z87A:
undetectable
1jipA-1z87A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE


(Paracoccus
denitrificans)
PF00155
(Aminotran_1_2)
5 ALA A 115
GLY A 268
THR A 105
LEU A 187
LEU A 220
None
0.91A 1jipA-2ay9A:
undetectable
1jipA-2ay9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT


(Streptococcus
mutans)
PF04223
(CitF)
5 PHE A 405
ALA A 404
GLY A 149
ALA A 396
LEU A 372
None
None
None
CIT  A 601 (-2.9A)
None
1.44A 1jipA-2hj0A:
undetectable
1jipA-2hj0A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsi PUTATIVE PEPTIDASE
M23


(Pseudomonas
aeruginosa)
PF01551
(Peptidase_M23)
5 PHE A 100
GLY A  37
LEU A  30
ALA A 274
LEU A  31
None
1.39A 1jipA-2hsiA:
undetectable
1jipA-2hsiA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE


(Bacillus
halodurans)
PF01019
(G_glu_transpept)
5 ALA A  34
GLY A 527
THR A 528
LEU A  41
ALA A  21
None
1.44A 1jipA-2nlzA:
0.6
1jipA-2nlzA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE


(Azospirillum
brasilense)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 PHE A 301
ALA A 300
VAL A 222
LEU A 225
ALA A 226
None
0.94A 1jipA-2q5oA:
undetectable
1jipA-2q5oA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES


(Corynebacterium
glutamicum)
PF00583
(Acetyltransf_1)
5 GLY A 138
LEU A 174
VAL A 141
ALA A 144
LEU A 170
EDO  A 211 (-3.3A)
None
None
None
None
1.44A 1jipA-2qecA:
undetectable
1jipA-2qecA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE


(Pseudomonas
aeruginosa)
PF01494
(FAD_binding_3)
5 ALA A 125
GLY A  29
LEU A  21
ALA A  22
LEU A  33
None
1.05A 1jipA-2rgjA:
undetectable
1jipA-2rgjA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE


(Paraburkholderia
xenovorans)
PF00171
(Aldedh)
5 GLY A 105
LEU A 204
LEU A  69
THR A 191
LEU A 209
None
1.18A 1jipA-2vroA:
undetectable
1jipA-2vroA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wt9 NICOTINAMIDASE

(Acinetobacter
baumannii)
PF00857
(Isochorismatase)
5 THR A 163
LEU A 210
VAL A  13
LEU A  12
ALA A  11
None
0.93A 1jipA-2wt9A:
undetectable
1jipA-2wt9A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy9 ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 48


(Mus musculus)
PF00651
(BTB)
5 ALA A  39
GLY A  74
VAL A  32
LEU A  65
LEU A  44
None
1.21A 1jipA-2yy9A:
undetectable
1jipA-2yy9A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii)
PF00067
(p450)
5 PHE A 246
ALA A 242
GLY A 341
LEU A 237
ALA A  91
HEM  A 450 (-4.9A)
HEM  A 450 (-3.5A)
HEM  A 450 (-4.1A)
MLI  A 500 ( 4.5A)
MLI  A 500 ( 2.9A)
1.42A 1jipA-3bdzA:
45.7
1jipA-3bdzA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjb PROBABLE
TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN


(Rhodococcus
jostii)
PF00440
(TetR_N)
5 ALA A  50
GLY A  55
THR A  56
LEU A  32
LEU A  67
None
SO4  A 319 (-3.2A)
SO4  A 320 (-2.8A)
None
None
1.29A 1jipA-3bjbA:
undetectable
1jipA-3bjbA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvg PUTATIVE METAL
BINDING PROTEIN


(Coccidioides
immitis)
PF12849
(PBP_like_2)
5 ALA A 255
TYR A  99
GLY A  43
VAL A  53
LEU A  52
None
1.23A 1jipA-3cvgA:
undetectable
1jipA-3cvgA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO


(Thermus
thermophilus)
PF01134
(GIDA)
5 GLY A 354
LEU A 313
LEU A 131
ALA A 132
LEU A 319
None
1.11A 1jipA-3g5sA:
undetectable
1jipA-3g5sA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae)
PF02374
(ArsA_ATPase)
5 ALA A 139
GLY A 131
LEU A 120
ALA A 125
LEU A 219
None
1.32A 1jipA-3h84A:
undetectable
1jipA-3h84A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 TYR A 100
GLY A  11
THR A  12
LEU A 287
ALA A 245
GOL  A 513 (-3.4A)
None
GOL  A 513 (-4.1A)
None
None
1.38A 1jipA-3hz6A:
undetectable
1jipA-3hz6A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus)
PF01766
(Birna_VP2)
5 GLY A  20
THR A  19
LEU A 166
LEU A  11
LEU A 164
None
1.39A 1jipA-3ideA:
undetectable
1jipA-3ideA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS


(Escherichia
coli)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
5 LEU A 632
LEU A 295
ALA A 292
THR A 622
LEU A 629
None
None
None
ADP  A1801 (-3.2A)
None
1.40A 1jipA-3k0sA:
1.2
1jipA-3k0sA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus)
PF00209
(SNF)
5 ALA A 504
LEU A 367
VAL A  95
LEU A  98
LEU A 371
BOG  A   1 ( 4.2A)
None
None
None
None
1.08A 1jipA-3mpnA:
0.2
1jipA-3mpnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0r RESPONSE REGULATOR

(Caulobacter
vibrioides)
PF00072
(Response_reg)
5 ALA A  85
GLY A  28
THR A  27
ALA A  35
LEU A  79
None
1.18A 1jipA-3n0rA:
undetectable
1jipA-3n0rA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE


(Sphingosinicella
xenopeptidilytica)
PF03576
(Peptidase_S58)
5 ALA A 259
GLY A 327
ALA A 270
THR A 320
LEU A 261
None
1.30A 1jipA-3nfbA:
undetectable
1jipA-3nfbA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng3 DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Mycobacterium
avium)
PF01791
(DeoC)
5 ALA A 207
LEU A 200
ALA A 197
THR A 159
LEU A 210
None
None
CL  A 224 ( 3.8A)
None
None
1.35A 1jipA-3ng3A:
undetectable
1jipA-3ng3A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opx PROTEIN SSM1

(Saccharomyces
cerevisiae)
PF13419
(HAD_2)
5 GLY A 162
LEU A 120
LEU A 159
THR A 140
LEU A  41
None
None
None
U5P  A 265 (-3.7A)
None
1.19A 1jipA-3opxA:
undetectable
1jipA-3opxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p56 RIBONUCLEASE H2
SUBUNIT A


(Homo sapiens)
PF01351
(RNase_HII)
5 ALA A  48
GLY A  37
LEU A  16
ALA A 189
LEU A  93
None
1.42A 1jipA-3p56A:
undetectable
1jipA-3p56A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4z GLYCOSYL HYDROLASE
FAMILY 32, N
TERMINAL


(Saccharophagus
degradans)
PF04616
(Glyco_hydro_43)
5 PHE A 313
ALA A  55
VAL A 140
LEU A 139
LEU A  57
None
0.92A 1jipA-3r4zA:
undetectable
1jipA-3r4zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc3 PUTATIVE DNA
REPLICATION
REGULATOR HDA


(Shewanella
amazonensis)
PF00308
(Bac_DnaA)
5 ALA A 124
LEU A 101
ARG A 131
LEU A 140
LEU A  98
None
1.32A 1jipA-3sc3A:
undetectable
1jipA-3sc3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Aquifex
aeolicus)
PF00275
(EPSP_synthase)
5 PHE A 316
ALA A 318
THR A 244
LEU A 347
LEU A 344
None
1.17A 1jipA-3swgA:
undetectable
1jipA-3swgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE


(Schizosaccharomyces
pombe)
PF00180
(Iso_dh)
5 ALA A 322
TYR A 326
LEU A  28
ALA A  25
LEU A 313
None
1.38A 1jipA-3ty4A:
undetectable
1jipA-3ty4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A


(Bacillus
subtilis)
PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C)
5 GLY A 829
LEU A 332
LEU A 216
THR A 832
LEU A 335
None
1.36A 1jipA-3u44A:
undetectable
1jipA-3u44A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II


(Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 ALA A 258
GLY A 238
LEU A 204
ALA A 418
LEU A 259
None
1.42A 1jipA-3vrbA:
undetectable
1jipA-3vrbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE


(Actinidia
chinensis)
PF01761
(DHQ_synthase)
5 ALA A 289
LEU A 204
LEU A 311
THR A 262
LEU A 259
PO4  A1380 (-3.2A)
None
None
PO4  A1380 (-3.4A)
PO4  A1380 (-4.5A)
1.39A 1jipA-3zokA:
undetectable
1jipA-3zokA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A


(Mycobacterium
tuberculosis)
PF00005
(ABC_tran)
5 THR A 650
LEU A 692
LEU A 668
ALA A 669
LEU A 695
None
1.37A 1jipA-3zqjA:
undetectable
1jipA-3zqjA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecg PUTATIVE
IRON-REGULATED
PROTEIN A


(Parabacteroides
distasonis)
PF09375
(Peptidase_M75)
5 ALA A 241
GLY A 220
VAL A 120
LEU A 123
ALA A 124
None
1.19A 1jipA-4ecgA:
undetectable
1jipA-4ecgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecm GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Bacillus
anthracis)
PF00483
(NTP_transferase)
5 ALA A 129
TYR A 174
GLY A 170
LEU A 203
LEU A 208
None
None
DAU  A 301 ( 4.4A)
None
None
1.17A 1jipA-4ecmA:
undetectable
1jipA-4ecmA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frt PROBABLE PORIN

(Pseudomonas
aeruginosa)
PF03573
(OprD)
5 GLY A 283
THR A 284
LEU A  60
VAL A 153
THR A 123
None
1.32A 1jipA-4frtA:
undetectable
1jipA-4frtA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN


(Enterococcus
faecalis)
PF00497
(SBP_bac_3)
5 ALA A 135
GLY A 110
LEU A 113
THR A 139
LEU A 145
None
None
None
GLN  A 302 (-4.3A)
None
1.17A 1jipA-4g4pA:
undetectable
1jipA-4g4pA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis)
PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C)
5 GLY A 266
ARG A 534
VAL A 279
LEU A 286
ALA A 287
BES  A 702 (-4.3A)
None
None
None
None
0.94A 1jipA-4gaaA:
undetectable
1jipA-4gaaA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica)
PF00933
(Glyco_hydro_3)
5 ALA A 265
GLY A 272
LEU A  25
ALA A 297
LEU A 292
None
1.22A 1jipA-4gvfA:
undetectable
1jipA-4gvfA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN


(Paracoccus
denitrificans)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 PHE A 279
ALA A 277
LEU A 123
ALA A 108
LEU A 124
None
1.35A 1jipA-4izgA:
undetectable
1jipA-4izgA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LEU A 348
VAL A 363
ALA A 201
THR A  71
LEU A 168
None
1.24A 1jipA-4jlwA:
undetectable
1jipA-4jlwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN


(Pseudomonas
putida)
PF00899
(ThiF)
PF08501
(Shikimate_dh_N)
5 GLY A 132
LEU A 215
LEU A 233
THR A 153
LEU A 185
NAD  A 301 (-3.4A)
None
None
None
None
1.42A 1jipA-4k28A:
undetectable
1jipA-4k28A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus)
PF01494
(FAD_binding_3)
5 ALA A  38
GLY A  20
LEU A 319
ALA A 290
LEU A  31
None
FAD  A 601 ( 4.8A)
None
None
None
1.24A 1jipA-4k5rA:
undetectable
1jipA-4k5rA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1)
PF03970
(Herpes_UL37_1)
5 ALA A  61
LEU A  68
LEU A 103
ALA A 102
THR A  56
None
1.45A 1jipA-4k70A:
undetectable
1jipA-4k70A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN


(Escherichia
coli;
Homo sapiens)
PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8)
5 ALA A1054
GLY A1046
THR A1045
LEU A1231
LEU A1234
None
0.85A 1jipA-4kegA:
undetectable
1jipA-4kegA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans)
PF00343
(Phosphorylase)
5 ALA A 738
LEU A 450
LEU A 428
ALA A 429
LEU A 447
None
0.89A 1jipA-4l22A:
undetectable
1jipA-4l22A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nek ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE


(Magnetospirillum
magneticum)
PF00378
(ECH_1)
5 PHE A  83
ALA A  80
TYR A  32
GLY A 104
LEU A  75
None
0.99A 1jipA-4nekA:
undetectable
1jipA-4nekA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nml RIBULOSE 5-PHOSPHATE
ISOMERASE


(Toxoplasma
gondii)
PF06026
(Rib_5-P_isom_A)
5 GLY A 139
THR A 138
LEU A 236
THR A 212
LEU A 216
None
0.86A 1jipA-4nmlA:
undetectable
1jipA-4nmlA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT


(Rhodopseudomonas
palustris)
PF03480
(DctP)
5 GLY A 138
LEU A  84
VAL A 147
LEU A 248
LEU A 105
None
1.25A 1jipA-4oanA:
undetectable
1jipA-4oanA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120)
no annotation 5 ALA A  76
VAL A  47
LEU A  59
THR A  53
LEU A  72
None
1.21A 1jipA-4oj5A:
undetectable
1jipA-4oj5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT


(Pseudomonas
aeruginosa)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
5 ALA A 180
GLY A  29
LEU A 429
ALA A 466
LEU A 432
None
1.37A 1jipA-4p72A:
undetectable
1jipA-4p72A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT


(Pseudomonas
aeruginosa)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
5 ALA A 640
GLY A 527
LEU A 670
ALA A 519
LEU A 666
None
1.09A 1jipA-4p72A:
undetectable
1jipA-4p72A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis)
PF00294
(PfkB)
5 ALA A 303
VAL A  59
LEU A  60
ALA A  56
LEU A 282
None
1.16A 1jipA-4pvvA:
undetectable
1jipA-4pvvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE


(Arabidopsis
thaliana)
PF01546
(Peptidase_M20)
5 ALA A 224
TYR A  89
GLY A 194
THR A 181
ALA A 205
None
1.42A 1jipA-4pxbA:
undetectable
1jipA-4pxbA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR


(Weissella
paramesenteroides)
PF13377
(Peripla_BP_3)
5 GLY A 251
VAL A 182
LEU A 181
ALA A 180
THR A 288
None
1.31A 1jipA-4rk6A:
undetectable
1jipA-4rk6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN


(Vibrio cholerae)
PF13531
(SBP_bac_11)
5 ALA A  30
TYR A  57
LEU A 101
VAL A  42
LEU A  41
None
1.05A 1jipA-4rxlA:
undetectable
1jipA-4rxlA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2p KETOSYNTHASE

(Myxococcus
fulvus)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ALA A 301
GLY A 321
THR A 320
VAL A 270
LEU A 271
None
1.07A 1jipA-4v2pA:
undetectable
1jipA-4v2pA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER


(Drosophila
melanogaster)
PF00209
(SNF)
5 PHE A  53
ALA A 359
LEU A 279
LEU A 414
LEU A 276
CL  A 603 ( 4.8A)
None
None
None
CLR  A 604 ( 4.7A)
1.44A 1jipA-4xnuA:
0.3
1jipA-4xnuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1


(Daucus carota)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 GLY A  43
LEU A 112
LEU A  37
ALA A  36
LEU A 115
None
1.29A 1jipA-4z61A:
undetectable
1jipA-4z61A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis)
PF00117
(GATase)
PF06418
(CTP_synth_N)
5 ALA A 380
GLY A 344
VAL A 307
ALA A 305
THR A 348
None
1.19A 1jipA-4zdkA:
undetectable
1jipA-4zdkA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a60 INORGANIC
TRIPHOSPHATASE


(Escherichia
coli)
PF01928
(CYTH)
5 ALA A 294
THR A 306
VAL A 254
ALA A 250
THR A 299
None
0.95A 1jipA-5a60A:
undetectable
1jipA-5a60A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avo HOMOSERINE
DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3)
5 PHE A 125
GLY A 132
LEU A   5
ALA A  14
THR A 128
None
1.17A 1jipA-5avoA:
undetectable
1jipA-5avoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2


(Mus musculus)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
5 ALA A 234
LEU A 492
VAL A 241
THR A 309
LEU A 495
None
1.29A 1jipA-5cm9A:
undetectable
1jipA-5cm9A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG


(Mus musculus)
PF09822
(ABC_transp_aux)
5 LEU A  84
VAL A 183
LEU A 198
ALA A 199
LEU A 241
None
1.24A 1jipA-5fmsA:
undetectable
1jipA-5fmsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g10 HDAH

(Pseudomonas
aeruginosa)
PF00850
(Hist_deacetyl)
5 ALA A 162
THR A 188
LEU A 127
VAL A 198
LEU A 123
None
1.20A 1jipA-5g10A:
undetectable
1jipA-5g10A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gte LACHRYMATORY-FACTOR
SYNTHASE


(Allium cepa)
PF10604
(Polyketide_cyc2)
5 PHE A 135
ALA A 116
TYR A 114
LEU A  90
VAL A  73
None
1.15A 1jipA-5gteA:
undetectable
1jipA-5gteA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqw PUTATIVE POLYKETIDE
SYNTHASE


(Brevibacillus
brevis)
PF14765
(PS-DH)
5 GLY A2428
LEU A2350
VAL A2461
LEU A2460
ALA A2459
None
0.94A 1jipA-5hqwA:
undetectable
1jipA-5hqwA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis)
PF13354
(Beta-lactamase2)
5 GLY A  55
LEU A 193
ARG A 249
ALA A 186
LEU A 194
None
1.27A 1jipA-5hw3A:
undetectable
1jipA-5hw3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Kribbella
flavida)
PF13416
(SBP_bac_8)
5 TYR A  57
GLY A 153
THR A 154
LEU A  47
LEU A 333
None
0.89A 1jipA-5ixpA:
undetectable
1jipA-5ixpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE


(Streptomyces
sp. ML694-90F3)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ALA A  84
GLY A  92
LEU A 118
ALA A 117
LEU A  73
None
1.18A 1jipA-5jjqA:
undetectable
1jipA-5jjqA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA


(Methylobacillus
flagellatus)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
5 GLY C 228
THR C 242
LEU C  78
VAL C  10
LEU C  11
None
1.34A 1jipA-5ks8C:
undetectable
1jipA-5ks8C:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Escherichia
coli)
no annotation 5 GLY A 148
LEU A 190
LEU A 132
THR A 172
LEU A 187
None
1.39A 1jipA-5lj9A:
undetectable
1jipA-5lj9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my5 ABC TRANSPORTER
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN


(Desulfovibrio
alaskensis)
PF12849
(PBP_like_2)
5 ALA A 219
GLY A  73
THR A  74
LEU A  34
LEU A   5
None
1.27A 1jipA-5my5A:
undetectable
1jipA-5my5A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora)
no annotation 5 ALA A 223
GLY A 149
THR A 148
LEU A 284
LEU A 224
None
1.39A 1jipA-5no5A:
undetectable
1jipA-5no5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr4 CLIP-ASSOCIATING
PROTEIN 2


(Homo sapiens)
no annotation 5 ALA A 191
THR A 155
LEU A 176
ALA A 134
LEU A 173
None
1.37A 1jipA-5nr4A:
undetectable
1jipA-5nr4A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td3 CATECHOL
1,2-DIOXYGENASE


(Burkholderia
vietnamiensis)
PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N)
5 GLY A  90
LEU A 120
LEU A  84
ALA A  83
THR A 115
None
None
EDO  A 403 ( 4.6A)
None
None
1.35A 1jipA-5td3A:
undetectable
1jipA-5td3A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR


(Homo sapiens)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R)
5 PHE A 305
ALA A 309
GLY A 241
LEU A 230
LEU A 233
None
1.34A 1jipA-5uakA:
0.0
1jipA-5uakA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v76 MICROCOMPARTMENTS
PROTEIN


(Haliangium
ochraceum)
no annotation 5 GLY A  87
VAL A   8
LEU A   9
ALA A  34
THR A  50
None
0.96A 1jipA-5v76A:
undetectable
1jipA-5v76A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN K


(Pseudomonas
aeruginosa)
no annotation 5 ALA X 244
LEU X 260
VAL X 224
LEU X 227
ALA X 228
None
0.83A 1jipA-5vtmX:
undetectable
1jipA-5vtmX:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN


(Human
alphaherpesvirus
1)
PF03970
(Herpes_UL37_1)
5 GLY A  99
LEU A  87
LEU A 106
ALA A 107
LEU A  33
None
1.31A 1jipA-5vylA:
undetectable
1jipA-5vylA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E


(Leishmania
major)
no annotation 5 ALA A 192
VAL A  96
LEU A 173
ALA A 174
LEU A 145
None
1.19A 1jipA-5wb5A:
undetectable
1jipA-5wb5A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae)
no annotation 5 ALA A 563
GLY A 504
VAL A 740
LEU A 743
LEU A 625
None
1.32A 1jipA-6fikA:
undetectable
1jipA-6fikA:
12.73