SIMILAR PATTERNS OF AMINO ACIDS FOR 1JHV_A_NIOA991_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhu METALLOPROTEINASE
INHIBITOR

(Streptomyces
nigrescens) 		PF03995
(Inhibitor_I36) 		5 GLY A  97
PHE A  52
LEU A 100
ARG A  55
GLY A 101
 None
 1.41A 1jhvA-1bhuA:
undetectable		 1jhvA-1bhuA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		5 GLY A 212
GLY A 233
PHE A 217
LEU A 218
SER A 234
 None
 1.34A 1jhvA-1bt2A:
undetectable		 1jhvA-1bt2A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174) 		PF01374
(Glyco_hydro_46) 		4 GLY A 139
GLY A 185
PHE A 186
LEU A 187
 None
 0.56A 1jhvA-1chkA:
undetectable		 1jhvA-1chkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 GLY A 194
GLY A 222
SER A 219
GLY A 224
 None
 0.76A 1jhvA-1cjxA:
undetectable		 1jhvA-1cjxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 THR A 305
GLY A 304
GLY A 271
PHE A 273
LEU A 274
 None
 1.49A 1jhvA-1cu1A:
0.2		 1jhvA-1cu1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7a PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Escherichia
coli) 		PF00731
(AIRC) 		5 THR A  22
GLY A 122
GLY A  71
SER A 103
GLY A  69
 None
None
AIR  A 300 (-3.6A)
None
None
 1.37A 1jhvA-1d7aA:
5.3		 1jhvA-1d7aA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 GLY A 240
GLY A  77
LEU A 237
SER A  76
ARG A  50
 None
 1.30A 1jhvA-1dj2A:
undetectable		 1jhvA-1dj2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 GLY A1324
GLY A1293
LEU A1295
GLY A1492
 None
 0.69A 1jhvA-1e6yA:
undetectable		 1jhvA-1e6yA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 THR A 180
GLY A 149
GLY A 235
PHE A 189
ARG A 238
 None
 1.45A 1jhvA-1fepA:
undetectable		 1jhvA-1fepA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gan GALECTIN-1

(Rhinella
arenarum) 		PF00337
(Gal-bind_lectin) 		5 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.10A 1jhvA-1ganA:
undetectable		 1jhvA-1ganA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 107
GLY A 113
LEU A 114
ARG A 109
GLY A 197
 None
 1.29A 1jhvA-1gz7A:
undetectable		 1jhvA-1gz7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 THR A 171
GLY A 115
GLY A 219
GLY A 250
 None
 0.66A 1jhvA-1hp1A:
undetectable		 1jhvA-1hp1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ik6 PYRUVATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR A  60
GLY A  32
GLY A  65
LEU A  62
GLY A  69
 None
 1.32A 1jhvA-1ik6A:
undetectable		 1jhvA-1ik6A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		5 THR A  90
GLY A  53
GLY A  32
LEU A  31
GLY A  35
 None
 1.30A 1jhvA-1iokA:
undetectable		 1jhvA-1iokA:
23.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		6 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
ARG A 279
 None
 1.01A 1jhvA-1j33A:
47.0		 1jhvA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		6 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLY A 303
 None
 0.47A 1jhvA-1j33A:
47.0		 1jhvA-1j33A:
36.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 GLY A 246
GLY A 199
PHE A 200
LEU A 197
GLY A 195
 None
 0.97A 1jhvA-1jftA:
undetectable		 1jhvA-1jftA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.66A 1jhvA-1jhzA:
undetectable		 1jhvA-1jhzA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		5 THR B 224
GLY B 221
GLY B 288
LEU B 285
GLY B 284
 None
 1.49A 1jhvA-1jk0B:
undetectable		 1jhvA-1jk0B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		5 THR A 147
GLY A 146
GLY A 153
PHE A 150
LEU A 151
 NA  A 501 ( 4.9A)
AMP  A 401 ( 4.1A)
None
None
None
 1.42A 1jhvA-1ka0A:
undetectable		 1jhvA-1ka0A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 THR A 312
GLY A 260
GLY A 190
SER A 208
GLY A 180
 None
 1.42A 1jhvA-1kb0A:
undetectable		 1jhvA-1kb0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbv MAJOR OUTER MEMBRANE
PROTEIN PAN 1

(Neisseria
gonorrhoeae) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 THR A  62
GLY A  65
GLY A 150
PHE A  63
ARG A  70
 None
 1.44A 1jhvA-1kbvA:
undetectable		 1jhvA-1kbvA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 THR A 168
GLY A 137
GLY A 143
PHE A 139
GLY A 203
 None
CO3  A1902 (-3.1A)
None
None
10A  A1901 (-3.7A)
 1.38A 1jhvA-1kphA:
undetectable		 1jhvA-1kphA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		4 GLY A  50
GLY A 181
LEU A 158
GLY A  43
 None
 0.76A 1jhvA-1kplA:
undetectable		 1jhvA-1kplA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 THR A 138
GLY A 134
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A 503 (-3.5A)
None
None
 1.16A 1jhvA-1kplA:
undetectable		 1jhvA-1kplA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lba T7 LYSOZYME

(Escherichia
virus T7) 		PF01510
(Amidase_2) 		5 GLY A  71
GLY A  78
PHE A  15
SER A  76
GLY A  66
 None
 1.27A 1jhvA-1lbaA:
undetectable		 1jhvA-1lbaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 GLY A 245
PHE A 194
SER A 247
ARG A 351
GLY A 191
 None
 1.33A 1jhvA-1lq2A:
1.9		 1jhvA-1lq2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 THR A  84
GLY A  87
GLY A  30
PHE A  49
GLY A  51
 None
 1.15A 1jhvA-1lq2A:
1.9		 1jhvA-1lq2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLY A 279
GLY A 259
LEU A 315
GLY A 256
 None
PLP  A1110 (-3.6A)
None
PLP  A1110 (-3.2A)
 0.74A 1jhvA-1m54A:
undetectable		 1jhvA-1m54A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		5 GLY A 216
GLY A 125
PHE A  33
LEU A 126
GLY A  36
 None
 1.27A 1jhvA-1miqA:
undetectable		 1jhvA-1miqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		5 GLY A 216
GLY A 125
PHE A  33
LEU A 126
GLY A 127
 None
 1.44A 1jhvA-1miqA:
undetectable		 1jhvA-1miqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf3 PAR-6B

(Mus musculus) 		PF00595
(PDZ) 		5 THR C 206
GLY C 207
GLY C 170
LEU C 202
GLY C 201
 THR  C 206 ( 0.8A)
GLY  C 207 ( 0.0A)
GLY  C 170 ( 0.0A)
LEU  C 202 ( 0.6A)
GLY  C 201 ( 0.0A)
 1.47A 1jhvA-1nf3C:
undetectable		 1jhvA-1nf3C:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03737
(RraA-like) 		4 GLY A  30
LEU A 105
ARG A  86
GLY A 107
 None
 0.76A 1jhvA-1nxjA:
undetectable		 1jhvA-1nxjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN

(Phaseolus
vulgaris) 		PF08263
(LRRNT_2) 		4 GLY A 238
GLY A 218
PHE A 217
LEU A 242
 None
 0.60A 1jhvA-1ogqA:
undetectable		 1jhvA-1ogqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 THR A 238
GLY A 239
GLY A 106
LEU A 104
GLY A 101
 None
CDM  A1284 ( 4.2A)
ANP  A1285 (-4.1A)
None
ANP  A1285 (-2.9A)
 1.37A 1jhvA-1oj4A:
undetectable		 1jhvA-1oj4A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Aquifex
aeolicus) 		PF01746
(tRNA_m1G_MT) 		4 THR A  89
GLY A 142
ARG A 116
GLY A 119
 None
 0.76A 1jhvA-1oy5A:
undetectable		 1jhvA-1oy5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		4 GLY A 265
LEU A 281
ARG A 264
GLY A 261
 None
 0.74A 1jhvA-1piiA:
undetectable		 1jhvA-1piiA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 405
GLY A 378
LEU A 377
SER A 127
 None
 0.75A 1jhvA-1pxtA:
undetectable		 1jhvA-1pxtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 GLY A  19
GLY A  24
SER A  63
GLY A  37
 None
 0.65A 1jhvA-1pyfA:
undetectable		 1jhvA-1pyfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		5 THR A 463
GLY A 467
GLY A 611
SER A 610
GLY A  24
 None
 1.15A 1jhvA-1r6vA:
undetectable		 1jhvA-1r6vA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 GLY A 100
GLY A 133
LEU A 155
GLY A 151
 None
 0.73A 1jhvA-1rf5A:
undetectable		 1jhvA-1rf5A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry4 CG5884-PA

(Drosophila
melanogaster) 		PF00595
(PDZ) 		5 THR A 209
GLY A 210
GLY A 173
LEU A 205
GLY A 203
 None
 1.41A 1jhvA-1ry4A:
undetectable		 1jhvA-1ry4A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		4 THR A 246
GLY A  49
GLY A 241
ARG A  53
 None
 0.57A 1jhvA-1sezA:
undetectable		 1jhvA-1sezA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 GLY P 183
LEU P 189
ARG P 164
GLY P 185
 None
 0.73A 1jhvA-1svcP:
undetectable		 1jhvA-1svcP:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 THR A 168
GLY A 137
GLY A 143
PHE A 139
GLY A 203
 None
CO3  A 902 (-3.1A)
None
None
16A  A1901 ( 3.7A)
 1.36A 1jhvA-1tpyA:
undetectable		 1jhvA-1tpyA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u11 PURE
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
MUTASE)

(Acetobacter
aceti) 		PF00731
(AIRC) 		5 THR A  36
GLY A 136
GLY A  85
SER A 117
GLY A  83
 None
None
CIT  A1001 (-4.3A)
None
None
 1.35A 1jhvA-1u11A:
4.5		 1jhvA-1u11A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		4 GLY A 117
GLY A  15
PHE A 148
GLY A  17
 NDP  A 188 (-2.3A)
None
None
NDP  A 188 ( 3.9A)
 0.74A 1jhvA-1u70A:
undetectable		 1jhvA-1u70A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Enterococcus
faecalis) 		PF02504
(FA_synthesis) 		4 THR A 190
GLY A 186
GLY A 207
LEU A 176
 None
 0.72A 1jhvA-1u7nA:
2.0		 1jhvA-1u7nA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 277
GLY A 179
LEU A 190
GLY A 188
 None
 0.74A 1jhvA-1v10A:
undetectable		 1jhvA-1v10A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 GLY A 112
LEU A 183
SER A 219
GLY A 171
 SO4  A1391 (-3.3A)
None
None
SO4  A1391 ( 4.6A)
 0.76A 1jhvA-1vz8A:
undetectable		 1jhvA-1vz8A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A1349
GLY A1046
PHE A1045
GLY A1298
 None
 0.77A 1jhvA-1wueA:
undetectable		 1jhvA-1wueA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqd SINAPYL ALCOHOL
DEHYDROGENASE

(Populus
tremuloides) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 294
GLY A 266
PHE A 265
LEU A 268
GLY A 246
 None
 1.21A 1jhvA-1yqdA:
2.4		 1jhvA-1yqdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2d N-ACETYLGALACTOSAMIN
E KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 THR A 128
GLY A 117
LEU A 115
GLY A 155
 None
 0.76A 1jhvA-2a2dA:
undetectable		 1jhvA-2a2dA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 GLY A 323
PHE A 324
LEU A 325
ARG A 296
 None
 0.68A 1jhvA-2acvA:
3.0		 1jhvA-2acvA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 GLY A 242
GLY A 172
LEU A 170
GLY A 227
 None
 0.77A 1jhvA-2b5mA:
undetectable		 1jhvA-2b5mA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		4 THR A 520
PHE A 507
LEU A 515
GLY A 530
 None
 0.70A 1jhvA-2bibA:
undetectable		 1jhvA-2bibA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 THR A 241
GLY A 413
GLY A 296
GLY A 202
 None
 0.63A 1jhvA-2bmoA:
undetectable		 1jhvA-2bmoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		4 GLY A 356
GLY A 327
PHE A 326
GLY A 331
 SO4  A1408 ( 3.9A)
None
None
None
 0.75A 1jhvA-2bwmA:
undetectable		 1jhvA-2bwmA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8m DNA-REPAIR PROTEIN
XRCC1

(Homo sapiens) 		PF00533
(BRCT) 		5 GLY A  81
GLY A 110
LEU A 105
SER A 112
GLY A 108
 None
 1.50A 1jhvA-2d8mA:
undetectable		 1jhvA-2d8mA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 GLY A 223
GLY A 187
PHE A 222
SER A  57
GLY A 192
 None
 1.26A 1jhvA-2e0iA:
undetectable		 1jhvA-2e0iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1t ACYL TRANSFERASE

(Chrysanthemum x
morifolium) 		PF02458
(Transferase) 		4 GLY A 449
GLY A 338
PHE A 339
SER A 285
 None
 0.75A 1jhvA-2e1tA:
undetectable		 1jhvA-2e1tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 GLY A 394
GLY A 339
PHE A 338
GLY A 611
 None
 0.76A 1jhvA-2eidA:
undetectable		 1jhvA-2eidA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp. PCC 6803) 		PF02153
(PDH) 		4 GLY A  17
GLY A   4
ARG A  20
GLY A  28
 None
 0.75A 1jhvA-2f1kA:
undetectable		 1jhvA-2f1kA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Escherichia
coli) 		PF01039
(Carboxyl_trans) 		4 GLY B 139
PHE B 142
LEU B 108
ARG B 144
 None
 0.77A 1jhvA-2f9yB:
undetectable		 1jhvA-2f9yB:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Escherichia
coli) 		PF01039
(Carboxyl_trans) 		5 GLY B 229
GLY B 205
PHE B 227
SER B 207
GLY B 163
 None
 1.36A 1jhvA-2f9yB:
undetectable		 1jhvA-2f9yB:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 THR A 887
GLY A 886
GLY A 893
PHE A 890
LEU A 891
 None
 1.42A 1jhvA-2fgeA:
undetectable		 1jhvA-2fgeA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvi CONSERVED
HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum) 		PF02663
(FmdE) 		4 GLY A  60
LEU A  87
SER A  51
GLY A  85
 UNL  A 400 ( 4.9A)
None
None
None
 0.73A 1jhvA-2gviA:
undetectable		 1jhvA-2gviA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP

(Vibrio harveyi) 		PF13407
(Peripla_BP_4) 		4 THR A 307
GLY A 291
GLY A 183
LEU A 187
 None
 0.74A 1jhvA-2hj9A:
undetectable		 1jhvA-2hj9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE

(Thermotoga
maritima) 		PF00480
(ROK) 		4 THR A 236
GLY A 293
GLY A 231
GLY A 213
 None
None
K  A 369 ( 4.7A)
GOL  A 370 (-3.6A)
 0.71A 1jhvA-2hoeA:
undetectable		 1jhvA-2hoeA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF13561
(adh_short_C2) 		5 THR A  46
GLY A  36
LEU A  34
SER A  40
GLY A  12
 None
 1.32A 1jhvA-2hq1A:
3.1		 1jhvA-2hq1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 GLY A 204
GLY A 184
LEU A 235
GLY A 181
 None
PLP  A 400 ( 4.1A)
None
PLP  A 400 (-3.5A)
 0.73A 1jhvA-2isqA:
undetectable		 1jhvA-2isqA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m48 E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Drosophila
melanogaster) 		PF01485
(IBR) 		4 THR A 372
GLY A 378
GLY A 388
PHE A 381
 None
 0.76A 1jhvA-2m48A:
undetectable		 1jhvA-2m48A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		5 THR A  47
GLY A  50
GLY A 402
PHE A  42
GLY A 400
 None
 1.36A 1jhvA-2o4vA:
undetectable		 1jhvA-2o4vA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Aquifex
aeolicus) 		PF13561
(adh_short_C2) 		5 THR A 120
GLY A 119
GLY A 163
PHE A 167
LEU A 164
 None
 1.37A 1jhvA-2p68A:
2.5		 1jhvA-2p68A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		4 GLY A 199
GLY A 337
LEU A 341
GLY A 343
 None
 0.77A 1jhvA-2pb0A:
undetectable		 1jhvA-2pb0A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		4 THR A  59
GLY A  38
PHE A  35
ARG A  33
 None
None
None
GG9  A 501 (-2.8A)
 0.72A 1jhvA-2pqdA:
undetectable		 1jhvA-2pqdA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		4 GLY A  93
GLY A 272
LEU A 274
SER A  11
 None
 0.65A 1jhvA-2qc3A:
undetectable		 1jhvA-2qc3A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 THR A 129
GLY A 156
PHE A 130
GLY A 390
 None
 0.74A 1jhvA-2qfrA:
undetectable		 1jhvA-2qfrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 GLY A 221
GLY A 199
LEU A 201
GLY A 203
 None
 0.73A 1jhvA-2qhxA:
2.9		 1jhvA-2qhxA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC

(Escherichia
coli) 		PF01032
(FecCD) 		4 THR A 129
GLY A 240
GLY A  92
GLY A  96
 None
 0.76A 1jhvA-2qi9A:
undetectable		 1jhvA-2qi9A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLY A 351
GLY A 384
SER A 341
GLY A 371
 None
GOL  A 804 (-3.6A)
None
None
 0.56A 1jhvA-2qk4A:
undetectable		 1jhvA-2qk4A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1

(Homo sapiens) 		PF00106
(adh_short) 		4 GLY A  14
GLY A 126
SER A  65
GLY A 123
 None
 0.76A 1jhvA-2qq5A:
2.3		 1jhvA-2qq5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsd UNCHARACTERIZED
CONSERVED PROTEIN

(Idiomarina
loihiensis) 		PF07566
(DUF1543) 		4 GLY A  19
GLY A  15
LEU A  24
GLY A  48
 None
 0.61A 1jhvA-2qsdA:
undetectable		 1jhvA-2qsdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 THR A 138
GLY A 134
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.13A 1jhvA-2r9hA:
undetectable		 1jhvA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.27A 1jhvA-2r9hA:
undetectable		 1jhvA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Streptococcus
mutans) 		PF01182
(Glucosamine_iso) 		4 THR A  38
GLY A 124
GLY A 191
PHE A 190
 None
 0.70A 1jhvA-2ri0A:
undetectable		 1jhvA-2ri0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE

(Lactococcus
lactis) 		PF13419
(HAD_2) 		5 THR A  16
GLY A  11
GLY A 119
LEU A 122
SER A 114
 None
MG  A1220 ( 4.5A)
None
None
ALF  A1219 (-2.8A)
 1.19A 1jhvA-2wf7A:
undetectable		 1jhvA-2wf7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		5 THR A 454
PHE A 427
LEU A 360
SER A 428
GLY A 421
 None
 1.43A 1jhvA-2x1mA:
1.6		 1jhvA-2x1mA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 GLY A 491
GLY A 506
LEU A 508
GLY A 516
 None
 0.74A 1jhvA-2x58A:
undetectable		 1jhvA-2x58A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLY A 343
GLY A 375
SER A 333
GLY A 362
 None
 0.70A 1jhvA-2xd4A:
undetectable		 1jhvA-2xd4A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLY A 642
GLY A 649
PHE A 598
LEU A 626
SER A 648
 None
 1.41A 1jhvA-2xf2A:
2.9		 1jhvA-2xf2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 THR A 184
GLY A 421
GLY A 144
GLY A 162
 None
 0.60A 1jhvA-2y27A:
undetectable		 1jhvA-2y27A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 THR A 774
GLY A 756
GLY A 778
SER A 751
GLY A 640
 None
 1.31A 1jhvA-2y8nA:
undetectable		 1jhvA-2y8nA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLY A 343
GLY A 377
SER A 333
GLY A 364
 None
 0.67A 1jhvA-2yw2A:
undetectable		 1jhvA-2yw2A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 THR A 172
GLY A 114
GLY A 217
GLY A 236
 None
 0.76A 1jhvA-2z1aA:
undetectable		 1jhvA-2z1aA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 GLY A 293
GLY A 297
PHE A 298
LEU A 299
 None
 0.71A 1jhvA-2zpaA:
undetectable		 1jhvA-2zpaA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 5 GLY A 693
GLY A 649
LEU A 670
SER A 644
GLY A 647
 None
 1.42A 1jhvA-3a0fA:
undetectable		 1jhvA-3a0fA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 5 THR A 437
GLY A 747
GLY A 461
LEU A 459
SER A 454
 None
 1.24A 1jhvA-3a0fA:
undetectable		 1jhvA-3a0fA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		4 GLY A 161
LEU A 118
ARG A 155
GLY A 159
 None
 0.61A 1jhvA-3a9lA:
undetectable		 1jhvA-3a9lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 353
PHE A 359
LEU A 379
SER A 191
ARG A 194
 None
 1.49A 1jhvA-3aoeA:
2.4		 1jhvA-3aoeA:
26.33