SIMILAR PATTERNS OF AMINO ACIDS FOR 1JHQ_A_NIOA991_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLY A 513
GLY A 144
SER A 393
ARG A 397
GLY A 142
 None
 1.41A 1jhqA-1b0kA:
undetectable		 1jhqA-1b0kA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0n PROTEIN (CSDB
PROTEIN)

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 GLY A 201
GLY A 234
PHE A 222
SER A 223
GLY A  97
 None
None
None
PLP  A 500 (-2.5A)
None
 1.50A 1jhqA-1c0nA:
0.0		 1jhqA-1c0nA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174) 		PF01374
(Glyco_hydro_46) 		4 GLY A 139
GLY A 185
PHE A 186
LEU A 187
 None
 0.53A 1jhqA-1chkA:
undetectable		 1jhqA-1chkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 GLY A 194
GLY A 222
SER A 219
GLY A 224
 None
 0.74A 1jhqA-1cjxA:
undetectable		 1jhqA-1cjxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 THR A 305
GLY A 304
GLY A 271
PHE A 273
LEU A 274
 None
 1.43A 1jhqA-1cu1A:
undetectable		 1jhqA-1cu1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7a PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Escherichia
coli) 		PF00731
(AIRC) 		5 THR A  22
GLY A 122
GLY A  71
SER A 103
GLY A  69
 None
None
AIR  A 300 (-3.6A)
None
None
 1.34A 1jhqA-1d7aA:
5.2		 1jhqA-1d7aA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans) 		PF00463
(ICL) 		5 THR A 104
GLY A  77
LEU A  79
SER A  97
GLY A 460
 None
 1.45A 1jhqA-1dquA:
0.3		 1jhqA-1dquA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 THR A 180
GLY A 149
GLY A 235
PHE A 189
ARG A 238
 None
 1.43A 1jhqA-1fepA:
undetectable		 1jhqA-1fepA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6v ANTIBODY HEAVY CHAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		4 GLY K 917
GLY K 835
ARG K 916
GLY K 896
 None
 0.72A 1jhqA-1g6vK:
undetectable		 1jhqA-1g6vK:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gan GALECTIN-1

(Rhinella
arenarum) 		PF00337
(Gal-bind_lectin) 		5 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.13A 1jhqA-1ganA:
undetectable		 1jhqA-1ganA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 107
GLY A 113
LEU A 114
ARG A 109
GLY A 197
 None
 1.30A 1jhqA-1gz7A:
undetectable		 1jhqA-1gz7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h21 SPLIT-SORET
CYTOCHROME C

(Desulfovibrio
desulfuricans) 		PF09719
(C_GCAxxG_C_C) 		5 GLY A  54
GLY A  45
PHE A  46
LEU A  72
GLY A  91
 None
 1.10A 1jhqA-1h21A:
undetectable		 1jhqA-1h21A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 GLY A 302
GLY A 309
ARG A 303
GLY A 403
 SO4  A 500 (-3.7A)
None
SO4  A 500 (-3.3A)
None
 0.73A 1jhqA-1hkwA:
undetectable		 1jhqA-1hkwA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 THR A 171
GLY A 115
GLY A 219
GLY A 250
 None
 0.69A 1jhqA-1hp1A:
undetectable		 1jhqA-1hp1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ik6 PYRUVATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR A  60
GLY A  32
GLY A  65
LEU A  62
GLY A  69
 None
 1.37A 1jhqA-1ik6A:
undetectable		 1jhqA-1ik6A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		4 GLY A 213
LEU A 227
SER A 199
GLY A 193
 None
None
None
PLP  A 401 (-3.6A)
 0.75A 1jhqA-1j0aA:
2.7		 1jhqA-1j0aA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		6 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
ARG A 279
 None
 0.98A 1jhqA-1j33A:
43.5		 1jhqA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		6 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLY A 303
 None
 0.48A 1jhqA-1j33A:
43.5		 1jhqA-1j33A:
36.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.58A 1jhqA-1jftA:
undetectable		 1jhqA-1jftA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.67A 1jhqA-1jhzA:
undetectable		 1jhqA-1jhzA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		5 THR B 224
GLY B 221
GLY B 288
LEU B 285
GLY B 284
 None
 1.48A 1jhqA-1jk0B:
undetectable		 1jhqA-1jk0B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 GLY A 411
GLY A 416
PHE A 418
LEU A 433
GLY A 370
 None
 1.28A 1jhqA-1k32A:
undetectable		 1jhqA-1k32A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		5 THR A1161
GLY A 997
LEU A1067
SER A1176
GLY A1066
 None
None
None
B12  A1248 (-4.9A)
None
 1.33A 1jhqA-1k7yA:
4.6		 1jhqA-1k7yA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 THR A 312
GLY A 260
GLY A 190
SER A 208
GLY A 180
 None
 1.41A 1jhqA-1kb0A:
undetectable		 1jhqA-1kb0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbv MAJOR OUTER MEMBRANE
PROTEIN PAN 1

(Neisseria
gonorrhoeae) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 THR A  62
GLY A  65
GLY A 150
PHE A  63
ARG A  70
 None
 1.42A 1jhqA-1kbvA:
undetectable		 1jhqA-1kbvA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 THR A 138
GLY A 134
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A 503 (-3.5A)
None
None
 1.16A 1jhqA-1kplA:
undetectable		 1jhqA-1kplA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 GLY A 245
PHE A 194
SER A 247
ARG A 351
GLY A 191
 None
 1.33A 1jhqA-1lq2A:
1.8		 1jhqA-1lq2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 THR A  84
GLY A  87
GLY A  30
PHE A  49
GLY A  51
 None
 1.14A 1jhqA-1lq2A:
1.8		 1jhqA-1lq2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 THR A 599
GLY A 562
LEU A 391
ARG A 386
GLY A 565
 None
 1.39A 1jhqA-1lq2A:
1.8		 1jhqA-1lq2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 357
GLY A 379
SER A 377
GLY A 374
 None
 0.76A 1jhqA-1lxtA:
undetectable		 1jhqA-1lxtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLY A 279
GLY A 259
LEU A 315
GLY A 256
 None
PLP  A1110 (-3.6A)
None
PLP  A1110 (-3.2A)
 0.74A 1jhqA-1m54A:
undetectable		 1jhqA-1m54A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		4 GLY A1035
GLY A1030
ARG A1034
GLY A1032
 None
IPA  A1135 ( 4.4A)
None
None
 0.72A 1jhqA-1mc2A:
undetectable		 1jhqA-1mc2A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		5 THR A1161
GLY A 997
LEU A1067
SER A1176
GLY A1066
 None
 1.29A 1jhqA-1mskA:
undetectable		 1jhqA-1mskA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 THR B 735
GLY A 133
LEU A 136
ARG A 112
GLY A  48
 None
None
None
None
FES  A4908 (-3.9A)
 1.23A 1jhqA-1n60B:
undetectable		 1jhqA-1n60B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf3 PAR-6B

(Mus musculus) 		PF00595
(PDZ) 		5 THR C 206
GLY C 207
GLY C 170
LEU C 202
GLY C 201
 THR  C 206 ( 0.8A)
GLY  C 207 ( 0.0A)
GLY  C 170 ( 0.0A)
LEU  C 202 ( 0.6A)
GLY  C 201 ( 0.0A)
 1.49A 1jhqA-1nf3C:
undetectable		 1jhqA-1nf3C:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN

(Phaseolus
vulgaris) 		PF08263
(LRRNT_2) 		4 GLY A 238
GLY A 218
PHE A 217
LEU A 242
 None
 0.65A 1jhqA-1ogqA:
undetectable		 1jhqA-1ogqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 THR A 238
GLY A 239
GLY A 106
LEU A 104
GLY A 101
 None
CDM  A1284 ( 4.2A)
ANP  A1285 (-4.1A)
None
ANP  A1285 (-2.9A)
 1.40A 1jhqA-1oj4A:
undetectable		 1jhqA-1oj4A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 GLY A  19
GLY A  24
SER A  63
GLY A  37
 None
 0.69A 1jhqA-1pyfA:
undetectable		 1jhqA-1pyfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 GLY A 100
GLY A 133
LEU A 155
GLY A 151
 None
 0.70A 1jhqA-1rf5A:
undetectable		 1jhqA-1rf5A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 189
GLY A 243
PHE A 244
GLY A 241
 None
 0.73A 1jhqA-1rx0A:
undetectable		 1jhqA-1rx0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		4 THR A 246
GLY A  49
GLY A 241
ARG A  53
 None
 0.52A 1jhqA-1sezA:
undetectable		 1jhqA-1sezA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 THR A 168
GLY A 137
GLY A 143
PHE A 139
GLY A 203
 None
CO3  A 902 (-3.1A)
None
None
16A  A1901 ( 3.7A)
 1.39A 1jhqA-1tpyA:
undetectable		 1jhqA-1tpyA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u11 PURE
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
MUTASE)

(Acetobacter
aceti) 		PF00731
(AIRC) 		5 THR A  36
GLY A 136
GLY A  85
SER A 117
GLY A  83
 None
None
CIT  A1001 (-4.3A)
None
None
 1.33A 1jhqA-1u11A:
undetectable		 1jhqA-1u11A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		4 GLY A 117
GLY A  15
PHE A 148
GLY A  17
 NDP  A 188 (-2.3A)
None
None
NDP  A 188 ( 3.9A)
 0.73A 1jhqA-1u70A:
undetectable		 1jhqA-1u70A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		4 THR A  10
GLY A  97
GLY A 131
GLY A 128
 None
 0.72A 1jhqA-1u9cA:
4.3		 1jhqA-1u9cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 THR A 286
GLY A 284
GLY A  87
LEU A  88
GLY A 160
 None
 1.15A 1jhqA-1ukcA:
undetectable		 1jhqA-1ukcA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 277
GLY A 179
LEU A 190
GLY A 188
 None
 0.75A 1jhqA-1v10A:
undetectable		 1jhqA-1v10A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		4 GLY A 293
GLY A 215
LEU A 212
GLY A 269
 None
 0.76A 1jhqA-1w8oA:
undetectable		 1jhqA-1w8oA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp5 TOPOISOMERASE IV

(Geobacillus
stearothermophilus) 		PF03989
(DNA_gyraseA_C) 		5 GLY A 235
GLY A 116
LEU A 160
ARG A 234
GLY A 187
 None
 1.41A 1jhqA-1wp5A:
undetectable		 1jhqA-1wp5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A1349
GLY A1046
PHE A1045
GLY A1298
 None
 0.76A 1jhqA-1wueA:
undetectable		 1jhqA-1wueA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Bacillus
anthracis) 		PF00731
(AIRC) 		5 THR A  17
GLY A 117
GLY A  66
SER A  98
GLY A  64
 None
 1.38A 1jhqA-1xmpA:
4.5		 1jhqA-1xmpA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqd SINAPYL ALCOHOL
DEHYDROGENASE

(Populus
tremuloides) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 294
GLY A 266
PHE A 265
LEU A 268
GLY A 246
 None
 1.29A 1jhqA-1yqdA:
2.4		 1jhqA-1yqdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqd SINAPYL ALCOHOL
DEHYDROGENASE

(Populus
tremuloides) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A 170
GLY A 302
LEU A 195
SER A  52
GLY A 278
 NAP  A 500 (-3.1A)
NAP  A 500 (-3.2A)
NAP  A 500 (-3.4A)
DTT  A 700 (-2.4A)
NAP  A 500 (-3.4A)
 1.25A 1jhqA-1yqdA:
2.4		 1jhqA-1yqdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 GLY A 323
PHE A 324
LEU A 325
ARG A 296
 None
 0.68A 1jhqA-2acvA:
1.3		 1jhqA-2acvA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON

(Salmonella
enterica) 		PF01569
(PAP2) 		5 GLY A 209
PHE A 213
LEU A 164
ARG A 215
GLY A 114
 None
 1.46A 1jhqA-2akcA:
undetectable		 1jhqA-2akcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 GLY A 168
GLY A  83
SER A 138
ARG A  78
GLY A  81
 None
 1.49A 1jhqA-2akpA:
undetectable		 1jhqA-2akpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		5 GLY A 193
GLY A 254
LEU A 255
ARG A 192
GLY A 131
 None
 1.41A 1jhqA-2ap1A:
undetectable		 1jhqA-2ap1A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		5 GLY A 193
PHE A 194
LEU A 255
ARG A 192
GLY A 131
 None
 1.45A 1jhqA-2ap1A:
undetectable		 1jhqA-2ap1A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		4 THR A 520
PHE A 507
LEU A 515
GLY A 530
 None
 0.76A 1jhqA-2bibA:
undetectable		 1jhqA-2bibA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 THR A 241
GLY A 413
GLY A 296
GLY A 202
 None
 0.63A 1jhqA-2bmoA:
undetectable		 1jhqA-2bmoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		4 GLY A 356
GLY A 327
PHE A 326
GLY A 331
 SO4  A1408 ( 3.9A)
None
None
None
 0.71A 1jhqA-2bwmA:
undetectable		 1jhqA-2bwmA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8m DNA-REPAIR PROTEIN
XRCC1

(Homo sapiens) 		PF00533
(BRCT) 		5 GLY A  81
GLY A 110
LEU A 105
SER A 112
GLY A 108
 None
 1.43A 1jhqA-2d8mA:
undetectable		 1jhqA-2d8mA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 GLY A 223
GLY A 187
PHE A 222
SER A  57
GLY A 192
 None
 1.27A 1jhqA-2e0iA:
undetectable		 1jhqA-2e0iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp. PCC 6803) 		PF02153
(PDH) 		4 GLY A  17
GLY A   4
ARG A  20
GLY A  28
 None
 0.76A 1jhqA-2f1kA:
undetectable		 1jhqA-2f1kA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Escherichia
coli) 		PF01039
(Carboxyl_trans) 		5 GLY B 229
GLY B 205
PHE B 227
SER B 207
GLY B 163
 None
 1.33A 1jhqA-2f9yB:
undetectable		 1jhqA-2f9yB:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		5 GLY A 272
GLY A  94
PHE A   7
SER A  97
GLY A   9
 None
 1.20A 1jhqA-2h1yA:
undetectable		 1jhqA-2h1yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP

(Vibrio harveyi) 		PF13407
(Peripla_BP_4) 		4 THR A 307
GLY A 291
GLY A 183
LEU A 187
 None
 0.75A 1jhqA-2hj9A:
undetectable		 1jhqA-2hj9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE

(Thermotoga
maritima) 		PF00480
(ROK) 		4 THR A 236
GLY A 293
GLY A 231
GLY A 213
 None
None
K  A 369 ( 4.7A)
GOL  A 370 (-3.6A)
 0.70A 1jhqA-2hoeA:
undetectable		 1jhqA-2hoeA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpe NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1

(Mus musculus) 		PF00498
(FHA) 		4 GLY A  52
GLY A 118
PHE A 117
SER A 120
 None
 0.76A 1jhqA-2jpeA:
undetectable		 1jhqA-2jpeA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m48 E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Drosophila
melanogaster) 		PF01485
(IBR) 		4 THR A 372
GLY A 378
GLY A 388
PHE A 381
 None
 0.73A 1jhqA-2m48A:
undetectable		 1jhqA-2m48A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpu RBP1

(Hordeum vulgare) 		PF00076
(RRM_1) 		5 THR A  20
GLY A  24
GLY A  14
LEU A  16
GLY A  53
 None
 1.41A 1jhqA-2mpuA:
undetectable		 1jhqA-2mpuA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		5 THR A  47
GLY A  50
GLY A 402
PHE A  42
GLY A 400
 None
 1.35A 1jhqA-2o4vA:
undetectable		 1jhqA-2o4vA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooj HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF11528
(DUF3224) 		5 GLY A 104
PHE A  80
LEU A 108
SER A 103
GLY A 110
 None
 1.38A 1jhqA-2oojA:
undetectable		 1jhqA-2oojA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooj HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF11528
(DUF3224) 		5 GLY A 113
GLY A 104
PHE A  80
SER A 103
GLY A 110
 None
 0.96A 1jhqA-2oojA:
undetectable		 1jhqA-2oojA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 THR A 150
GLY A 181
LEU A 281
GLY A 274
 None
 0.75A 1jhqA-2p0uA:
undetectable		 1jhqA-2p0uA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 GLY A 209
GLY A  38
PHE A  37
LEU A 234
GLY A 236
 None
 1.17A 1jhqA-2pqdA:
undetectable		 1jhqA-2pqdA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		4 THR A  59
GLY A  38
PHE A  35
ARG A  33
 None
None
None
GG9  A 501 (-2.8A)
 0.73A 1jhqA-2pqdA:
undetectable		 1jhqA-2pqdA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF12708
(Pectate_lyase_3) 		5 GLY A 242
GLY A 221
PHE A 198
LEU A 222
GLY A 251
 None
 1.26A 1jhqA-2pyhA:
undetectable		 1jhqA-2pyhA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		4 GLY A  93
GLY A 272
LEU A 274
SER A  11
 None
 0.67A 1jhqA-2qc3A:
undetectable		 1jhqA-2qc3A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 THR A 129
GLY A 156
PHE A 130
GLY A 390
 None
 0.75A 1jhqA-2qfrA:
undetectable		 1jhqA-2qfrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC

(Escherichia
coli) 		PF01032
(FecCD) 		4 THR A 129
GLY A 240
GLY A  92
GLY A  96
 None
 0.75A 1jhqA-2qi9A:
undetectable		 1jhqA-2qi9A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLY A 351
GLY A 384
SER A 341
GLY A 371
 None
GOL  A 804 (-3.6A)
None
None
 0.57A 1jhqA-2qk4A:
undetectable		 1jhqA-2qk4A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1

(Homo sapiens) 		PF00106
(adh_short) 		4 GLY A  14
GLY A 126
SER A  65
GLY A 123
 None
 0.76A 1jhqA-2qq5A:
2.3		 1jhqA-2qq5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsd UNCHARACTERIZED
CONSERVED PROTEIN

(Idiomarina
loihiensis) 		PF07566
(DUF1543) 		4 GLY A  19
GLY A  15
LEU A  24
GLY A  48
 None
 0.68A 1jhqA-2qsdA:
undetectable		 1jhqA-2qsdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.26A 1jhqA-2r9hA:
undetectable		 1jhqA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Streptococcus
mutans) 		PF01182
(Glucosamine_iso) 		4 THR A  38
GLY A 124
GLY A 191
PHE A 190
 None
 0.71A 1jhqA-2ri0A:
undetectable		 1jhqA-2ri0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE

(Lactococcus
lactis) 		PF13419
(HAD_2) 		5 THR A  16
GLY A  11
GLY A 119
LEU A 122
SER A 114
 None
MG  A1220 ( 4.5A)
None
None
ALF  A1219 (-2.8A)
 1.21A 1jhqA-2wf7A:
undetectable		 1jhqA-2wf7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		5 THR A 454
PHE A 427
LEU A 360
SER A 428
GLY A 421
 None
 1.42A 1jhqA-2x1mA:
undetectable		 1jhqA-2x1mA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 GLY A 491
GLY A 506
LEU A 508
GLY A 516
 None
 0.70A 1jhqA-2x58A:
undetectable		 1jhqA-2x58A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLY A 343
GLY A 375
SER A 333
GLY A 362
 None
 0.70A 1jhqA-2xd4A:
undetectable		 1jhqA-2xd4A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLY A 642
GLY A 649
PHE A 598
LEU A 626
SER A 648
 None
 1.40A 1jhqA-2xf2A:
3.6		 1jhqA-2xf2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 THR A 184
GLY A 421
GLY A 144
GLY A 162
 None
 0.64A 1jhqA-2y27A:
undetectable		 1jhqA-2y27A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 THR A 774
GLY A 756
GLY A 778
SER A 751
GLY A 640
 None
 1.32A 1jhqA-2y8nA:
undetectable		 1jhqA-2y8nA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoy RBAM17540

(Bacillus
amyloliquefaciens) 		PF03067
(LPMO_10) 		5 GLY A  89
GLY A  58
LEU A  97
SER A  59
GLY A  96
 None
 1.44A 1jhqA-2yoyA:
undetectable		 1jhqA-2yoyA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLY A 343
GLY A 377
SER A 333
GLY A 364
 None
 0.69A 1jhqA-2yw2A:
undetectable		 1jhqA-2yw2A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc7 BETA-LACTAMASE ACT-1

(Klebsiella
pneumoniae) 		PF00144
(Beta-lactamase) 		5 GLY A  81
GLY A 251
LEU A 254
SER A 247
GLY A  74
 None
 1.32A 1jhqA-2zc7A:
undetectable		 1jhqA-2zc7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 5 GLY A 693
GLY A 649
LEU A 670
SER A 644
GLY A 647
 None
 1.46A 1jhqA-3a0fA:
undetectable		 1jhqA-3a0fA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		4 GLY A 161
LEU A 118
ARG A 155
GLY A 159
 None
 0.66A 1jhqA-3a9lA:
undetectable		 1jhqA-3a9lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 THR A  82
GLY A  83
GLY A 191
LEU A  36
GLY A 144
 None
 1.37A 1jhqA-3afeA:
undetectable		 1jhqA-3afeA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 353
PHE A 359
LEU A 379
SER A 191
ARG A 194
 None
 1.49A 1jhqA-3aoeA:
2.5		 1jhqA-3aoeA:
26.33