SIMILAR PATTERNS OF AMINO ACIDS FOR 1JHA_A_NIOA991

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174)
PF01374
(Glyco_hydro_46)
4 GLY A 139
GLY A 185
PHE A 186
LEU A 187
None
0.60A 1jhaA-1chkA:
undetectable
1jhaA-1chkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE


(Gallus gallus)
PF00186
(DHFR_1)
4 GLY A 117
GLY A  15
PHE A 148
GLY A  17
NAP  A 191 (-3.3A)
MBO  A 201 ( 4.2A)
None
NAP  A 191 (-3.6A)
0.74A 1jhaA-1dr6A:
undetectable
1jhaA-1dr6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE


(Pyrococcus
horikoshii)
PF00291
(PALP)
4 GLY A 213
LEU A 227
SER A 199
GLY A 193
None
None
None
PLP  A 401 (-3.6A)
0.75A 1jhaA-1j0aA:
2.4
1jhaA-1j0aA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j33 COBT

(Thermus
thermophilus)
PF02277
(DBI_PRT)
6 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
ARG A 279
None
0.97A 1jhaA-1j33A:
42.4
1jhaA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j33 COBT

(Thermus
thermophilus)
PF02277
(DBI_PRT)
6 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLY A 303
None
0.46A 1jhaA-1j33A:
42.4
1jhaA-1j33A:
36.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR


(Escherichia
coli)
PF00356
(LacI)
PF13377
(Peripla_BP_3)
4 GLY A 246
GLY A 199
PHE A 200
GLY A 195
None
0.56A 1jhaA-1jftA:
undetectable
1jhaA-1jftA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR


(Escherichia
coli)
PF13377
(Peripla_BP_3)
4 GLY A 246
GLY A 199
PHE A 200
GLY A 195
None
0.67A 1jhaA-1jhzA:
undetectable
1jhaA-1jhzA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkm HPRK PROTEIN

(Lactobacillus
casei)
PF07475
(Hpr_kinase_C)
4 GLY A 172
GLY A 218
PHE A 217
ARG A 174
None
0.75A 1jhaA-1kkmA:
undetectable
1jhaA-1kkmA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN


(Salmonella
enterica)
PF00654
(Voltage_CLC)
4 THR A 138
GLY A 134
GLY A 355
GLY A 106
None
None
CL  A 503 (-3.5A)
None
0.73A 1jhaA-1kplA:
undetectable
1jhaA-1kplA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE


(Homo sapiens)
PF00291
(PALP)
4 GLY A 279
GLY A 259
LEU A 315
GLY A 256
None
PLP  A1110 (-3.6A)
None
PLP  A1110 (-3.2A)
0.75A 1jhaA-1m54A:
undetectable
1jhaA-1m54A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense)
PF00882
(Zn_dep_PLPC)
PF01477
(PLAT)
4 THR A  16
GLY A  51
PHE A  48
GLY A   7
None
0.78A 1jhaA-1olpA:
undetectable
1jhaA-1olpA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis)
PF00248
(Aldo_ket_red)
4 GLY A  19
GLY A  24
SER A  63
GLY A  37
None
0.72A 1jhaA-1pyfA:
undetectable
1jhaA-1pyfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
4 GLY A 100
GLY A 133
LEU A 155
GLY A 151
None
0.66A 1jhaA-1rf5A:
undetectable
1jhaA-1rf5A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL


(Nicotiana
tabacum)
PF01593
(Amino_oxidase)
4 THR A 246
GLY A  49
GLY A 241
ARG A  53
None
0.51A 1jhaA-1sezA:
undetectable
1jhaA-1sezA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus)
PF00135
(COesterase)
4 GLY A 215
GLY A 464
LEU A 467
GLY A 131
None
0.75A 1jhaA-1thgA:
2.0
1jhaA-1thgA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u70 DIHYDROFOLATE
REDUCTASE


(Mus musculus)
PF00186
(DHFR_1)
4 GLY A 117
GLY A  15
PHE A 148
GLY A  17
NDP  A 188 (-2.3A)
None
None
NDP  A 188 ( 3.9A)
0.72A 1jhaA-1u70A:
undetectable
1jhaA-1u70A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 GLY A 277
GLY A 179
LEU A 190
GLY A 188
None
0.76A 1jhaA-1v10A:
undetectable
1jhaA-1v10A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
4 THR A 241
GLY A 413
GLY A 296
GLY A 202
None
0.61A 1jhaA-2bmoA:
undetectable
1jhaA-2bmoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1t ACYL TRANSFERASE

(Chrysanthemum x
morifolium)
PF02458
(Transferase)
4 GLY A 449
GLY A 338
PHE A 339
SER A 285
None
0.72A 1jhaA-2e1tA:
undetectable
1jhaA-2e1tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum)
PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929)
4 GLY A 394
GLY A 339
PHE A 338
GLY A 611
None
0.75A 1jhaA-2eidA:
undetectable
1jhaA-2eidA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m48 E3 UBIQUITIN-PROTEIN
LIGASE PARKIN


(Drosophila
melanogaster)
PF01485
(IBR)
4 THR A 372
GLY A 378
GLY A 388
PHE A 381
None
0.75A 1jhaA-2m48A:
undetectable
1jhaA-2m48A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Agrobacterium
sp.)
PF00275
(EPSP_synthase)
4 THR A  59
GLY A  38
PHE A  35
ARG A  33
None
None
None
GG9  A 501 (-2.8A)
0.70A 1jhaA-2pqdA:
undetectable
1jhaA-2pqdA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Mycobacterium
tuberculosis)
PF00698
(Acyl_transf_1)
4 GLY A  93
GLY A 272
LEU A 274
SER A  11
None
0.66A 1jhaA-2qc3A:
undetectable
1jhaA-2qc3A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE


(Phaseolus
vulgaris)
PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N)
4 THR A 129
GLY A 156
PHE A 130
GLY A 390
None
0.70A 1jhaA-2qfrA:
undetectable
1jhaA-2qfrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3


(Homo sapiens)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
4 GLY A 351
GLY A 384
SER A 341
GLY A 371
None
GOL  A 804 (-3.6A)
None
None
0.57A 1jhaA-2qk4A:
undetectable
1jhaA-2qk4A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsd UNCHARACTERIZED
CONSERVED PROTEIN


(Idiomarina
loihiensis)
PF07566
(DUF1543)
4 GLY A  19
GLY A  15
LEU A  24
GLY A  48
None
0.64A 1jhaA-2qsdA:
undetectable
1jhaA-2qsdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE


(Bacillus
subtilis)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
4 GLY A 343
GLY A 375
SER A 333
GLY A 362
None
0.77A 1jhaA-2xd4A:
undetectable
1jhaA-2xd4A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE


(Burkholderia
cenocepacia)
PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2)
4 THR A 184
GLY A 421
GLY A 144
GLY A 162
None
0.63A 1jhaA-2y27A:
undetectable
1jhaA-2y27A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE


(Aquifex
aeolicus)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
4 GLY A 343
GLY A 377
SER A 333
GLY A 364
None
0.71A 1jhaA-2yw2A:
undetectable
1jhaA-2yw2A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE


(Bacillus virus
NIT1)
PF05908
(Gamma_PGA_hydro)
4 GLY A 161
LEU A 118
ARG A 155
GLY A 159
None
0.67A 1jhaA-3a9lA:
undetectable
1jhaA-3a9lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571


(Deinococcus
radiodurans)
PF01266
(DAO)
4 THR A  79
GLY A  45
GLY A 383
GLY A 375
ADP  A 411 (-3.6A)
ADP  A 411 (-3.5A)
None
ADP  A 411 ( 4.4A)
0.74A 1jhaA-3c4nA:
undetectable
1jhaA-3c4nA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLY A 368
GLY A  38
PHE A  37
GLY A 318
None
0.67A 1jhaA-3dfhA:
undetectable
1jhaA-3dfhA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli)
PF07969
(Amidohydro_3)
4 THR A 200
GLY A 181
GLY A 165
GLY A 158
None
0.77A 1jhaA-3g77A:
2.6
1jhaA-3g77A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT


(Mycobacterium
tuberculosis)
PF00694
(Aconitase_C)
4 GLY A  98
GLY A  68
PHE A  71
SER A  94
None
0.66A 1jhaA-3h5jA:
undetectable
1jhaA-3h5jA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdg UNCHARACTERIZED
PROTEIN


(Wolinella
succinogenes)
PF00072
(Response_reg)
4 THR A  58
GLY A  67
GLY A  39
GLY A  44
None
0.77A 1jhaA-3hdgA:
3.0
1jhaA-3hdgA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219


(Lactobacillus
plantarum)
PF10282
(Lactonase)
4 GLY A  34
GLY A   8
PHE A   7
GLY A  17
None
0.70A 1jhaA-3hfqA:
undetectable
1jhaA-3hfqA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT
NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT


(Eubacterium
barkeri)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C)
4 THR D  60
GLY D  45
GLY C 109
GLY C  33
FES  D 908 (-4.2A)
FES  D 908 ( 3.2A)
FAD  C 900 ( 3.8A)
FAD  C 900 (-3.3A)
0.65A 1jhaA-3hrdD:
undetectable
1jhaA-3hrdD:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih6 PUTATIVE ZINC
PROTEASE


(Bordetella
pertussis)
PF05193
(Peptidase_M16_C)
4 GLY A 342
PHE A 341
LEU A 313
ARG A 440
None
0.64A 1jhaA-3ih6A:
undetectable
1jhaA-3ih6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Staphylococcus
aureus)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 GLY A 301
PHE A 298
SER A 113
GLY A 181
None
0.68A 1jhaA-3il7A:
undetectable
1jhaA-3il7A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7t MACROPHAGE BINDING
PROTEIN


(Coccidioides
immitis)
PF01965
(DJ-1_PfpI)
4 THR A 233
GLY A 138
GLY A 103
GLY A 135
None
0.71A 1jhaA-3n7tA:
3.4
1jhaA-3n7tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR


(Pseudomonas
putida)
PF00532
(Peripla_BP_1)
4 GLY A 186
GLY A 200
PHE A 201
SER A 167
None
0.67A 1jhaA-3o75A:
undetectable
1jhaA-3o75A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN


(Actinobacillus
pleuropneumoniae)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
4 GLY A 438
GLY A 521
LEU A 503
GLY A 505
None
None
None
GOL  A 529 ( 4.3A)
0.75A 1jhaA-3pqsA:
undetectable
1jhaA-3pqsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE


(Mycobacteroides
abscessus)
PF00557
(Peptidase_M24)
4 GLY A 176
PHE A 175
LEU A 220
ARG A 165
None
0.68A 1jhaA-3tavA:
undetectable
1jhaA-3tavA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE


(Sphaerobacter
thermophilus)
PF00583
(Acetyltransf_1)
5 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
None
1.29A 1jhaA-3tt2A:
undetectable
1jhaA-3tt2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN


(Sinorhizobium
meliloti)
PF08534
(Redoxin)
4 THR A  48
GLY A 147
GLY A 153
SER A 152
None
0.76A 1jhaA-3umaA:
undetectable
1jhaA-3umaA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes)
PF00089
(Trypsin)
4 THR A 143
GLY A 191
GLY A  19
SER A  43
None
0.76A 1jhaA-3ureA:
undetectable
1jhaA-3ureA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE


(Glycine max)
PF00291
(PALP)
4 GLY A 253
GLY A 233
LEU A 284
GLY A 230
None
PLP  A 500 (-3.8A)
None
PLP  A 500 (-3.2A)
0.74A 1jhaA-3vbeA:
undetectable
1jhaA-3vbeA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE


(Eisenia fetida)
PF00759
(Glyco_hydro_9)
4 GLY A 168
GLY A  82
PHE A  83
GLY A 135
None
0.78A 1jhaA-3wc3A:
undetectable
1jhaA-3wc3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Cryptococcus
neoformans)
PF00478
(IMPDH)
PF00571
(CBS)
4 GLY B 358
GLY B 340
ARG B 355
GLY B 338
None
MOA  B1526 (-4.0A)
None
None
0.77A 1jhaA-4af0B:
undetectable
1jhaA-4af0B:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 GLY A 237
GLY A  50
LEU A  48
GLY A 167
None
None
CSX  A  35 ( 4.4A)
None
0.72A 1jhaA-4akoA:
undetectable
1jhaA-4akoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE


(Pseudogluconobacter
saccharoketogenes)
PF13360
(PQQ_2)
4 THR A 121
GLY A 103
SER A 556
GLY A 598
None
0.68A 1jhaA-4cvcA:
undetectable
1jhaA-4cvcA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
4 THR A 928
GLY A 933
PHE A 930
GLY A 893
None
0.76A 1jhaA-4fysA:
undetectable
1jhaA-4fysA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF


(Thermococcus
kodakarensis)
PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF)
4 THR A 605
GLY A 602
GLY A 559
SER A 562
None
0.75A 1jhaA-4g9iA:
2.1
1jhaA-4g9iA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E


(Methylobacterium
extorquens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 GLY A  80
GLY A  46
SER A  51
GLY A  86
None
0.77A 1jhaA-4gi2A:
3.2
1jhaA-4gi2A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE


(Mycobacterium
tuberculosis)
PF00682
(HMGL-like)
PF07836
(DmpG_comm)
4 GLY A 199
GLY A 231
SER A 290
GLY A 229
None
0.67A 1jhaA-4jn6A:
2.9
1jhaA-4jn6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k29 ENOYL-COA
HYDRATASE/ISOMERASE


(Xanthobacter
autotrophicus)
PF00378
(ECH_1)
4 GLY A 140
LEU A 137
SER A 242
GLY A 142
None
0.78A 1jhaA-4k29A:
undetectable
1jhaA-4k29A:
24.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE


(Salmonella
enterica)
PF02277
(DBI_PRT)
7 THR A 180
GLY A 202
GLY A 264
PHE A 265
LEU A 266
ARG A 314
GLY A 316
SO4  A 402 (-2.9A)
SO4  A 402 (-3.6A)
None
None
None
None
None
0.42A 1jhaA-4kqkA:
62.9
1jhaA-4kqkA:
98.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE


(Salmonella
enterica)
PF02277
(DBI_PRT)
7 THR A 180
GLY A 202
GLY A 264
PHE A 265
SER A 291
ARG A 314
GLY A 316
SO4  A 402 (-2.9A)
SO4  A 402 (-3.6A)
None
None
None
None
None
0.39A 1jhaA-4kqkA:
62.9
1jhaA-4kqkA:
98.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB


(Staphylococcus
epidermidis)
PF00083
(Sugar_tr)
4 GLY A 284
GLY A  28
SER A 263
GLY A  24
None
0.74A 1jhaA-4ldsA:
undetectable
1jhaA-4ldsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE


(Eggerthella
lenta)
PF00905
(Transpeptidase)
4 THR A 191
GLY A 257
GLY A 246
GLY A 250
None
0.69A 1jhaA-4mnrA:
undetectable
1jhaA-4mnrA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Desulfovibrio
salexigens)
PF03480
(DctP)
4 GLY A  86
LEU A  74
SER A  33
GLY A  91
None
None
CL  A 403 (-4.6A)
None
0.74A 1jhaA-4n6dA:
undetectable
1jhaA-4n6dA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
4 GLY A 445
GLY A 530
LEU A 510
GLY A 512
None
0.78A 1jhaA-4o4xA:
undetectable
1jhaA-4o4xA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 GLY A4535
GLY A4448
PHE A4447
GLY A4451
None
0.69A 1jhaA-4opeA:
undetectable
1jhaA-4opeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE


(Vibrio cholerae)
PF00926
(DHBP_synthase)
5 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
None
0.90A 1jhaA-4p8eA:
undetectable
1jhaA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wec SHORT CHAIN
DEHYDROGENASE


(Mycolicibacterium
smegmatis)
PF13561
(adh_short_C2)
4 THR A 239
GLY A 171
GLY A 135
GLY A 178
None
0.72A 1jhaA-4wecA:
4.1
1jhaA-4wecA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x68 BETA-LACTAMASE

(Pseudomonas
aeruginosa)
PF00144
(Beta-lactamase)
4 GLY A 297
GLY A 183
PHE A 185
GLY A 248
None
0.70A 1jhaA-4x68A:
undetectable
1jhaA-4x68A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
4 THR A 135
GLY A 166
LEU A 266
GLY A 259
None
0.76A 1jhaA-4yjyA:
undetectable
1jhaA-4yjyA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae)
PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2)
4 GLY A 127
GLY A 234
PHE A 243
GLY A  96
None
0.77A 1jhaA-4yw5A:
undetectable
1jhaA-4yw5A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN


(Bombyx mori)
PF00248
(Aldo_ket_red)
4 THR A 312
GLY A 227
GLY A 309
PHE A 310
None
None
None
ACT  A 406 (-3.5A)
0.64A 1jhaA-5az0A:
undetectable
1jhaA-5az0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN


([Candida]
glabrata)
PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central)
4 THR A 123
GLY A  15
GLY A  63
PHE A 113
None
0.74A 1jhaA-5d0fA:
undetectable
1jhaA-5d0fA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 GLY A 325
GLY A 238
PHE A 237
GLY A 241
None
0.76A 1jhaA-5erbA:
undetectable
1jhaA-5erbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 THR A 320
GLY A 325
GLY A 238
GLY A 241
None
0.70A 1jhaA-5erbA:
undetectable
1jhaA-5erbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1u 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE


(Campylobacter
jejuni)
PF00701
(DHDPS)
4 THR A 222
GLY A   8
GLY A 202
LEU A 199
None
0.73A 1jhaA-5f1uA:
1.8
1jhaA-5f1uA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor)
no annotation 4 GLY A  16
GLY A 127
SER A 167
GLY A 129
None
0.77A 1jhaA-5fsbA:
undetectable
1jhaA-5fsbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor)
no annotation 4 GLY A  91
GLY A 205
SER A  14
GLY A 207
None
0.71A 1jhaA-5fsbA:
undetectable
1jhaA-5fsbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium)
PF00202
(Aminotran_3)
5 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
None
1.14A 1jhaA-5g0aA:
undetectable
1jhaA-5g0aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjn LYSINE/ORNITHINE
DECARBOXYLASE


(Selenomonas
ruminantium)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
4 GLY A 319
PHE A 318
LEU A 285
GLY A 288
None
0.73A 1jhaA-5gjnA:
undetectable
1jhaA-5gjnA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome)
PF00232
(Glyco_hydro_1)
4 GLY A 450
GLY A  14
PHE A  15
ARG A  10
None
0.76A 1jhaA-5gnxA:
undetectable
1jhaA-5gnxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER


(Methanocaldococcus
jannaschii)
PF01699
(Na_Ca_ex)
4 GLY A 119
GLY A 242
LEU A 245
GLY A 128
SR  A 402 ( 4.6A)
None
None
None
0.76A 1jhaA-5hxsA:
undetectable
1jhaA-5hxsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus)
PF00291
(PALP)
4 GLY A 185
GLY A 237
LEU A 214
GLY A 235
LLP  A  42 ( 3.4A)
None
None
None
0.75A 1jhaA-5jjcA:
undetectable
1jhaA-5jjcA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnq PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE


([Clostridium]
bolteae)
PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1)
5 GLY A 216
PHE A 217
LEU A 214
SER A  16
GLY A 212
None
1.07A 1jhaA-5jnqA:
undetectable
1jhaA-5jnqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY


(Myxococcus
xanthus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 THR A 292
GLY A 152
LEU A  87
GLY A 133
None
0.76A 1jhaA-5k1sA:
3.6
1jhaA-5k1sA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT


(Xanthobacter
autotrophicus)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
4 GLY B 285
GLY B 311
SER B 314
GLY B  20
None
AMP  B 801 (-3.5A)
None
AMP  B 801 ( 3.7A)
0.72A 1jhaA-5m45B:
undetectable
1jhaA-5m45B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus)
no annotation 4 GLY A  96
GLY A 175
PHE A 174
GLY A   4
None
0.72A 1jhaA-5n7qA:
undetectable
1jhaA-5n7qA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa)
no annotation 4 GLY A 441
GLY A 447
LEU A  91
GLY A 449
None
0.77A 1jhaA-5nbsA:
undetectable
1jhaA-5nbsA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Escherichia
coli)
PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD)
4 THR J 389
GLY J 374
GLY J 381
PHE J 377
None
0.78A 1jhaA-5nilJ:
undetectable
1jhaA-5nilJ:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szj RAS-RELATED PROTEIN
RAB-10


(Homo sapiens)
PF00071
(Ras)
4 GLY A 121
GLY A  94
PHE A  97
SER A  96
None
0.75A 1jhaA-5szjA:
undetectable
1jhaA-5szjA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
4 GLY A 109
GLY A 190
PHE A 107
GLY A 192
None
0.72A 1jhaA-5t98A:
undetectable
1jhaA-5t98A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1


(Escherichia
virus T4;
Homo sapiens)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
4 GLY A  94
GLY A2265
SER A2268
GLY A2238
None
0.73A 1jhaA-5tzyA:
undetectable
1jhaA-5tzyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE


(Malus domestica)
no annotation 4 THR A 132
GLY A 163
LEU A 263
GLY A 256
None
0.75A 1jhaA-5uc5A:
undetectable
1jhaA-5uc5A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE


(Cryptosporidium
parvum)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 212
GLY A 138
GLY A 332
GLY A 355
NAD  A 501 ( 4.1A)
SAH  A 502 ( 3.9A)
NAD  A 501 (-3.5A)
NAD  A 501 (-3.4A)
0.77A 1jhaA-5utuA:
2.4
1jhaA-5utuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCD

(Pseudomonas
aeruginosa)
PF01039
(Carboxyl_trans)
4 GLY B 185
GLY B 162
SER B 164
GLY B 120
None
0.75A 1jhaA-5vipB:
2.5
1jhaA-5vipB:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT


(Diaphorobacter
sp. DS2)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
4 THR A 241
GLY A 413
GLY A 296
GLY A 202
None
0.61A 1jhaA-5xbpA:
undetectable
1jhaA-5xbpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE


(Bacillus
licheniformis)
no annotation 4 GLY A  86
GLY A 149
LEU A 150
SER A 108
GLY  A  86 ( 0.0A)
GLY  A 149 ( 0.0A)
LEU  A 150 ( 0.6A)
SER  A 108 ( 0.0A)
0.72A 1jhaA-5xluA:
undetectable
1jhaA-5xluA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-)
no annotation 4 THR A 407
GLY A 352
GLY A 380
GLY A 348
None
0.65A 1jhaA-5xyaA:
undetectable
1jhaA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris)
no annotation 4 GLY A 510
PHE A 476
SER A 469
GLY A 513
None
0.69A 1jhaA-5z0uA:
undetectable
1jhaA-5z0uA:
10.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE


(Yersinia
enterocolitica)
no annotation 8 THR A 179
GLY A 201
GLY A 263
PHE A 264
LEU A 265
SER A 290
ARG A 313
GLY A 315
SO4  A 401 (-2.8A)
SO4  A 401 ( 3.7A)
None
None
None
None
None
None
0.39A 1jhaA-6b5fA:
59.5
1jhaA-6b5fA:
67.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM


(Saccharomyces
cerevisiae)
no annotation 4 GLY A 339
GLY A  34
LEU A  33
GLY A  37
None
0.70A 1jhaA-6c6lA:
undetectable
1jhaA-6c6lA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1


(Danio rerio)
no annotation 4 GLY A 188
GLY A 250
LEU A 113
SER A 248
None
0.77A 1jhaA-6d14A:
undetectable
1jhaA-6d14A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus)
no annotation 4 GLY A1759
GLY A1727
LEU A1728
GLY A2013
None
0.71A 1jhaA-6fayA:
undetectable
1jhaA-6fayA:
13.37