SIMILAR PATTERNS OF AMINO ACIDS FOR 1JG4_A_SAMA500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 GLU A 140
GLY A 167
ILE A   3
LEU A 175
 NAD  A 600 (-2.5A)
None
None
None
 0.91A 1jg4A-1ad3A:
5.2		 1jg4A-1ad3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		4 GLU A  81
GLY A  83
GLU A 107
ASP A 134
 SAH  A 699 (-3.4A)
SAH  A 699 (-3.2A)
SAH  A 699 (-2.9A)
SAH  A 699 (-3.5A)
 0.32A 1jg4A-1dl5A:
28.4		 1jg4A-1dl5A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		4 GLY A  87
ARG A  71
ILE A 430
ASP A 423
 FAD  A 527 (-3.9A)
FAD  A 527 (-4.0A)
FAD  A 527 (-4.7A)
None
 0.79A 1jg4A-1f8rA:
2.7		 1jg4A-1f8rA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 GLU A 105
GLY A 107
GLU A 131
ASP A 161
 None
SAM  A 301 (-2.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
 0.47A 1jg4A-1i9gA:
13.5		 1jg4A-1i9gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig0 THIAMIN
PYROPHOSPHOKINASE

(Saccharomyces
cerevisiae) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 GLY A 191
ILE A  43
LEU A 189
ASP A 126
 None
 0.93A 1jg4A-1ig0A:
undetectable		 1jg4A-1ig0A:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01135
(PCMT) 		8 GLU A  97
GLY A  99
SER A 102
GLU A 121
ARG A 122
ILE A 123
LEU A 126
ASP A 148
 None
ADN  A 500 (-3.2A)
None
ADN  A 500 (-2.9A)
None
ADN  A 500 (-4.6A)
ADN  A 500 (-4.2A)
ADN  A 500 (-3.7A)
 0.15A 1jg4A-1jg3A:
41.2		 1jg4A-1jg3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kr5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01135
(PCMT) 		5 GLY A  85
SER A  88
ILE A 111
LEU A 114
ASP A 141
 SAH  A 300 (-3.5A)
SAH  A 300 (-2.6A)
SAH  A 300 ( 4.9A)
SAH  A 300 (-4.7A)
SAH  A 300 (-3.7A)
 0.42A 1jg4A-1kr5A:
31.7		 1jg4A-1kr5A:
35.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		4 GLY A 109
SER A 143
ILE A 173
LEU A  79
 None
 0.90A 1jg4A-1kzhA:
undetectable		 1jg4A-1kzhA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis) 		PF01263
(Aldose_epim) 		4 GLU A 222
GLY A 187
SER A 266
LEU A 175
 None
 0.74A 1jg4A-1nsvA:
undetectable		 1jg4A-1nsvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		4 GLY A 108
SER A 111
GLU A 132
ASP A 160
 None
CL  A 266 ( 4.4A)
None
None
 0.75A 1jg4A-1o54A:
13.4		 1jg4A-1o54A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oru YUAD PROTEIN

(Bacillus
subtilis) 		no annotation 4 GLY A 124
SER A 110
ILE A 163
LEU A 121
 None
 0.91A 1jg4A-1oruA:
undetectable		 1jg4A-1oruA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT

(Pseudomonas
putida) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY B 229
SER B 134
LEU B 173
ASP B 155
 None
 0.93A 1jg4A-1qs0B:
undetectable		 1jg4A-1qs0B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		5 GLU A  43
GLY A  45
GLU A  66
LEU A  71
ASP A  91
 None
 0.62A 1jg4A-1qyrA:
9.4		 1jg4A-1qyrA:
20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r18 PROTEIN-L-ISOASPARTA
TE(D-ASPARTATE)-O-ME
THYLTRANSFERASE

(Drosophila
melanogaster) 		PF01135
(PCMT) 		5 GLY A  86
SER A  89
GLU A 115
LEU A 120
ASP A 147
 SAH  A 300 (-3.4A)
SAH  A 300 (-2.5A)
SAH  A 300 (-2.9A)
SAH  A 300 (-4.7A)
SAH  A 300 (-3.6A)
 0.23A 1jg4A-1r18A:
28.0		 1jg4A-1r18A:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp0 CYTOCHROME C OXIDASE
ASSEMBLY PROTEIN
CTAG

(Sinorhizobium
meliloti) 		PF04442
(CtaG_Cox11) 		4 GLY A  61
ARG A  59
LEU A  29
ASP A  57
 None
 0.79A 1jg4A-1sp0A:
undetectable		 1jg4A-1sp0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		4 GLY A  94
ARG A  40
ILE A  31
LEU A  38
 None
 0.73A 1jg4A-1sr8A:
undetectable		 1jg4A-1sr8A:
24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vbf 231AA LONG
HYPOTHETICAL
PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01135
(PCMT) 		4 GLU A  76
GLY A  78
GLU A  99
ASP A 124
 None
 0.31A 1jg4A-1vbfA:
27.8		 1jg4A-1vbfA:
31.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 GLY A 199
SER A 206
ILE A 129
ASP A 112
 None
PER  A 409 ( 4.1A)
None
None
 0.92A 1jg4A-1wx4A:
undetectable		 1jg4A-1wx4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		5 GLU A  96
GLY A  98
SER A 101
GLU A 122
ASP A 150
 None
 0.96A 1jg4A-1yb2A:
10.1		 1jg4A-1yb2A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		4 GLU A  86
GLY A  88
GLU A 118
LEU A 123
 None
 0.59A 1jg4A-1zkdA:
7.2		 1jg4A-1zkdA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		4 GLU A  62
GLY A  64
GLU A  85
LEU A  90
 None
SAM  A4000 (-3.1A)
SAM  A4000 (-2.8A)
SAM  A4000 (-4.8A)
 0.50A 1jg4A-1zq9A:
9.9		 1jg4A-1zq9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		4 GLY A  64
GLU A  85
LEU A  90
ASP A 113
 SAM  A4000 (-3.1A)
SAM  A4000 (-2.8A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
 0.48A 1jg4A-1zq9A:
9.9		 1jg4A-1zq9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		4 GLU A 109
GLY A 111
GLU A 135
ASP A 173
 None
SAM  A 601 (-2.9A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.4A)
 0.60A 1jg4A-2b25A:
12.9		 1jg4A-2b25A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		4 GLY A  47
ILE A  50
LEU A  72
ASP A 237
 None
 0.84A 1jg4A-2bznA:
undetectable		 1jg4A-2bznA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Bacillus
subtilis) 		PF02390
(Methyltransf_4) 		4 GLU A  44
GLY A  46
GLU A  69
ASP A  96
 None
K  A 250 (-3.9A)
None
None
 0.79A 1jg4A-2fcaA:
7.1		 1jg4A-2fcaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnp TRANSCRIPTIONAL
REGULATOR

(Streptococcus
pneumoniae) 		PF04198
(Sugar-bind) 		4 SER A  76
GLU A  65
ILE A  79
ASP A  58
 None
 0.93A 1jg4A-2gnpA:
undetectable		 1jg4A-2gnpA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpy O-METHYLTRANSFERASE

(Bacillus
halodurans) 		PF01596
(Methyltransf_3) 		4 GLU A  60
GLY A  62
GLU A  85
ASP A 113
 None
None
None
ZN  A 306 ( 4.7A)
 0.54A 1jg4A-2gpyA:
11.9		 1jg4A-2gpyA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLY A 316
ARG A 148
ILE A 150
ASP A 147
 None
 0.73A 1jg4A-2gz3A:
undetectable		 1jg4A-2gz3A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 4 GLY A 286
ILE A 259
LEU A 283
ASP A 239
 None
 0.89A 1jg4A-2invA:
undetectable		 1jg4A-2invA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l2g IGF2R DOMAIN 11

(Monodelphis
domestica) 		PF00878
(CIMR) 		4 GLY A1580
SER A1595
ILE A1626
LEU A1606
 None
 0.75A 1jg4A-2l2gA:
undetectable		 1jg4A-2l2gA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6p UNCHARACTERIZED
PROTEIN MB2076

(Mycobacterium
bovis) 		PF13397
(RbpA) 		4 GLY A  62
ARG A  33
ILE A  65
LEU A  64
 None
 0.92A 1jg4A-2m6pA:
undetectable		 1jg4A-2m6pA:
13.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		5 GLY A  88
SER A  91
GLU A 116
ARG A 117
LEU A 121
 SAH  A 301 (-3.1A)
SAH  A 301 (-2.8A)
SAH  A 301 (-2.8A)
None
SAH  A 301 ( 4.1A)
 0.19A 1jg4A-2pbfA:
28.5		 1jg4A-2pbfA:
32.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		4 GLU A  84
GLY A  86
GLU A 121
ASP A 176
 None
 0.54A 1jg4A-2qy6A:
6.8		 1jg4A-2qy6A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 4 GLU B 426
SER B 418
ILE B  23
LEU B 420
 None
 0.75A 1jg4A-2vduB:
undetectable		 1jg4A-2vduB:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE

(Methylophaga
aminisulfidivorans) 		PF00743
(FMO-like) 		4 SER A 231
ILE A 273
LEU A 206
ASP A 193
 None
 0.71A 1jg4A-2xlrA:
undetectable		 1jg4A-2xlrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		4 GLU A  97
GLY A  99
GLU A 120
ASP A 148
 None
SAM  A 601 (-3.2A)
SAM  A 601 (-2.7A)
SAM  A 601 (-3.1A)
 0.62A 1jg4A-2yvlA:
12.8		 1jg4A-2yvlA:
26.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF01135
(PCMT) 		7 GLU A  83
GLY A  85
GLU A 109
ARG A 110
ILE A 111
LEU A 114
ASP A 136
 None
 0.41A 1jg4A-2yxeA:
35.3		 1jg4A-2yxeA:
50.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zz8 LIPL32 PROTEIN

(Leptospira
interrogans) 		PF12103
(Lipl32) 		4 GLY A  75
SER A 210
ILE A 116
ASP A 148
 None
 0.91A 1jg4A-2zz8A:
undetectable		 1jg4A-2zz8A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		4 GLY A 107
ARG A 104
LEU A 109
ASP A 101
 None
 0.93A 1jg4A-3bh1A:
undetectable		 1jg4A-3bh1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dn7 CYCLIC NUCLEOTIDE
BINDING REGULATORY
PROTEIN

(Cytophaga
hutchinsonii) 		PF00027
(cNMP_binding) 		4 GLU A 112
ARG A 117
ILE A 118
LEU A 121
 None
 0.81A 1jg4A-3dn7A:
undetectable		 1jg4A-3dn7A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		4 GLU A  69
GLY A  71
GLU A  94
ASP A 121
 None
 0.60A 1jg4A-3dxxA:
7.6		 1jg4A-3dxxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		4 GLU A 214
GLY A 244
SER A 249
LEU A 247
 None
 0.92A 1jg4A-3edmA:
5.4		 1jg4A-3edmA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fma PROTEIN SMY2

(Saccharomyces
cerevisiae) 		PF02213
(GYF) 		4 GLY A  29
SER A  17
ILE A  51
ASP A  22
 None
 0.92A 1jg4A-3fmaA:
undetectable		 1jg4A-3fmaA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		5 GLU A  52
GLY A  54
GLU A  75
LEU A  80
ASP A  99
 None
 0.65A 1jg4A-3futA:
9.5		 1jg4A-3futA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLU A  36
GLY A  38
GLU A  59
LEU A  64
ASP A  84
 None
 0.58A 1jg4A-3fydA:
11.1		 1jg4A-3fydA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 4 GLY A  94
GLU A 117
LEU A 122
ASP A 144
 None
FMT  A 315 (-3.6A)
FMT  A 315 (-4.0A)
None
 0.61A 1jg4A-3gjyA:
8.8		 1jg4A-3gjyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLU A  36
GLY A  38
GLU A  59
LEU A  64
ASP A  84
 SAM  A 300 (-4.4A)
SAM  A 300 (-3.3A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.8A)
SAM  A 300 (-3.7A)
 0.58A 1jg4A-3gryA:
10.5		 1jg4A-3gryA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn6 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Borreliella
burgdorferi) 		PF01182
(Glucosamine_iso) 		4 GLY A 109
SER A 112
ILE A 159
ASP A  72
 None
 0.84A 1jg4A-3hn6A:
undetectable		 1jg4A-3hn6A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyv SULFIDE-QUINONE
REDUCTASE

(Aquifex
aeolicus) 		PF07992
(Pyr_redox_2) 		4 GLY A 396
ARG A  22
ILE A  71
LEU A  66
 None
 0.91A 1jg4A-3hyvA:
2.1		 1jg4A-3hyvA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP0
VP3

(Parechovirus B;
Parechovirus B) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 GLU C  79
SER B 173
ILE C 225
ASP C 105
 None
 0.84A 1jg4A-3jb4C:
undetectable		 1jg4A-3jb4C:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 GLU E 322
GLY E 325
GLU E 328
ASP E 310
 None
 0.92A 1jg4A-3kfuE:
undetectable		 1jg4A-3kfuE:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 GLU A   3
GLY A   1
ILE A  35
ASP A  29
 None
 0.77A 1jg4A-3kl4A:
undetectable		 1jg4A-3kl4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 GLY A 488
ILE A 508
LEU A 478
ASP A 513
 None
 0.94A 1jg4A-3la4A:
undetectable		 1jg4A-3la4A:
15.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Escherichia
coli) 		PF01135
(PCMT) 		8 GLU A  81
GLY A  83
SER A  86
GLU A 104
ARG A 105
ILE A 106
LEU A 109
ASP A 131
 SAH  A 300 ( 4.7A)
SAH  A 300 (-3.4A)
SAH  A 300 (-2.5A)
SAH  A 300 (-2.9A)
None
SAH  A 300 (-4.3A)
SAH  A 300 (-4.8A)
SAH  A 300 (-3.7A)
 0.35A 1jg4A-3lbfA:
33.2		 1jg4A-3lbfA:
36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 GLU A  99
GLY A 101
GLU A 125
ASP A 153
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.1A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.1A)
 0.77A 1jg4A-3lgaA:
14.1		 1jg4A-3lgaA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		4 GLU A  77
GLY A  79
GLU A 102
ARG A 103
 SO4  A 233 (-4.0A)
None
None
None
 0.72A 1jg4A-3ntvA:
11.5		 1jg4A-3ntvA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLU A  64
GLY A  66
GLU A 101
ASP A 156
 SAM  A 670 (-4.0A)
SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
 0.50A 1jg4A-3ps9A:
5.8		 1jg4A-3ps9A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLU A  64
GLY A  66
GLU A 101
ASP A 156
 None
 0.78A 1jg4A-3pvcA:
6.5		 1jg4A-3pvcA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 GLY A  88
ILE A  55
LEU A  83
ASP A  14
 None
 0.92A 1jg4A-3tqiA:
2.4		 1jg4A-3tqiA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		4 GLU A  38
GLY A  40
GLU A  61
LEU A  66
 None
 0.62A 1jg4A-3tqsA:
9.7		 1jg4A-3tqsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 GLU A 393
SER A 216
GLU A 221
LEU A 218
 GLU  A 393 (-0.6A)
SER  A 216 ( 0.0A)
GLU  A 221 (-0.6A)
LEU  A 218 ( 0.6A)
 0.86A 1jg4A-3ulkA:
3.6		 1jg4A-3ulkA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		4 GLU A  44
GLY A  46
GLU A  71
LEU A  76
 None
 0.53A 1jg4A-3uzuA:
8.9		 1jg4A-3uzuA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		4 GLU A  44
GLY A  46
LEU A  76
ASP A  94
 None
 0.66A 1jg4A-3uzuA:
8.9		 1jg4A-3uzuA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 SER A 103
ARG A  29
LEU A 190
ASP A  32
 None
None
GDP  A 400 (-4.9A)
None
 0.86A 1jg4A-3wgkA:
2.4		 1jg4A-3wgkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		4 GLU A 614
GLY A 615
LEU A 506
ASP A 444
 None
 0.85A 1jg4A-3x3yA:
undetectable		 1jg4A-3x3yA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		4 GLY A 126
ILE A   8
LEU A  31
ASP A   5
 None
 0.87A 1jg4A-4cnkA:
2.3		 1jg4A-4cnkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		4 GLY A 190
ARG A 188
ILE A 149
LEU A 150
 None
 0.86A 1jg4A-4e3zA:
4.3		 1jg4A-4e3zA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etm LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE YFKJ

(Bacillus
subtilis) 		PF01451
(LMWPc) 		4 SER A  39
ILE A  85
LEU A   5
ASP A 113
 K  A 203 (-3.5A)
None
None
None
 0.90A 1jg4A-4etmA:
undetectable		 1jg4A-4etmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd6 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
2

(Aedes aegypti) 		PF00583
(Acetyltransf_1) 		4 GLY A  82
ILE A 135
LEU A  80
ASP A 170
 None
 0.93A 1jg4A-4fd6A:
undetectable		 1jg4A-4fd6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		4 GLU A  61
GLY A  63
GLU A  85
ASP A 111
 None
ACT  A 402 (-3.4A)
ACT  A 402 (-2.9A)
None
 0.53A 1jg4A-4gc5A:
9.2		 1jg4A-4gc5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0p ACETATE KINASE

(Cryptococcus
neoformans) 		PF00871
(Acetate_kinase) 		4 GLY A 104
ILE A 111
LEU A 156
ASP A 108
 None
 0.92A 1jg4A-4h0pA:
undetectable		 1jg4A-4h0pA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2k TRYPSIN INHIBITOR

(Enterolobium
contortisiliquum) 		PF00197
(Kunitz_legume) 		4 GLU A 112
SER A  91
ILE A 106
LEU A  93
 None
 0.90A 1jg4A-4j2kA:
undetectable		 1jg4A-4j2kA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koq SINGLE-STRANDED
DNA-BINDING PROTEIN
WHY3, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF08536
(Whirly) 		4 GLU A 120
GLY A 121
ARG A 103
LEU A 123
 None
 0.74A 1jg4A-4koqA:
undetectable		 1jg4A-4koqA:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio cholerae) 		PF01135
(PCMT) 		8 GLU A  81
GLY A  83
SER A  86
GLU A 104
ARG A 105
ILE A 106
LEU A 109
ASP A 131
 SAH  A 301 ( 4.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-2.6A)
SAH  A 301 (-2.7A)
ACT  A 303 ( 2.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.0A)
 0.43A 1jg4A-4l7vA:
28.0		 1jg4A-4l7vA:
36.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 GLU A 101
GLY A 103
SER A 106
GLU A 125
LEU A 130
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.0A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-4.5A)
 0.24A 1jg4A-4m38A:
10.6		 1jg4A-4m38A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		4 SER A  99
ILE A 323
LEU A 255
ASP A  81
 None
 0.80A 1jg4A-4mguA:
undetectable		 1jg4A-4mguA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		4 GLY A 190
SER A 119
ILE A 160
ASP A 278
 None
 0.84A 1jg4A-4nruA:
undetectable		 1jg4A-4nruA:
19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o29 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrobaculum
aerophilum) 		PF01135
(PCMT) 		6 GLU A  78
GLY A  80
SER A  83
GLU A 104
LEU A 109
ASP A 132
 SAH  A 500 (-4.3A)
SAH  A 500 (-3.1A)
SAH  A 500 (-2.9A)
SAH  A 500 (-2.8A)
SAH  A 500 (-3.8A)
SAH  A 500 (-4.0A)
 0.40A 1jg4A-4o29A:
33.2		 1jg4A-4o29A:
47.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3i OSSERK2 D128N

(Oryza sativa) 		PF08263
(LRRNT_2)
PF11921
(DUF3439) 		4 GLU A 174
SER A 126
ILE A 169
LEU A 148
 None
 0.93A 1jg4A-4q3iA:
undetectable		 1jg4A-4q3iA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		4 SER A 485
ARG A 445
ILE A 494
LEU A 489
 None
 0.84A 1jg4A-4qi4A:
2.6		 1jg4A-4qi4A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 SER A 485
ARG A 445
ILE A 494
LEU A 489
 None
 0.88A 1jg4A-4qi6A:
undetectable		 1jg4A-4qi6A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 SER A 485
ARG A 445
ILE A 494
LEU A 489
 None
 0.76A 1jg4A-4qi7A:
undetectable		 1jg4A-4qi7A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v19 MITORIBOSOMAL
PROTEIN BL28M,
MRPL28

(Sus scrofa) 		PF00830
(Ribosomal_L28) 		4 GLU 1  83
GLY 1  81
ILE 1 135
LEU 1 132
 None
 0.84A 1jg4A-4v191:
undetectable		 1jg4A-4v191:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxy RNA
METHYLTRANSFERASE

(Salinibacter
ruber) 		PF13847
(Methyltransf_31) 		4 GLY A  31
GLU A  53
LEU A  58
ASP A  81
 SAH  A 201 (-3.4A)
SAH  A 201 (-2.8A)
SAH  A 201 (-4.4A)
SAH  A 201 (-3.6A)
 0.32A 1jg4A-5bxyA:
12.0		 1jg4A-5bxyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		4 GLU A 109
GLY A 111
GLU A 135
ASP A 163
 None
SAH  A 301 (-3.2A)
SAH  A 301 (-2.2A)
SAH  A 301 (-2.7A)
 0.48A 1jg4A-5ccxA:
14.0		 1jg4A-5ccxA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 GLU A 101
GLY A 103
SER A 106
GLU A 125
LEU A 130
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.0A)
SAH  A 401 (-2.7A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.2A)
 0.32A 1jg4A-5ekuA:
10.0		 1jg4A-5ekuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		5 GLU B 116
GLY B 118
SER B 121
GLU B 139
ASP B 168
 None
SAM  B 401 (-3.4A)
SAM  B 401 (-3.1A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.5A)
 1.03A 1jg4A-5ergB:
11.5		 1jg4A-5ergB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		4 GLY A 324
SER A 293
ILE A 312
ASP A 357
 None
 0.84A 1jg4A-5gyzA:
undetectable		 1jg4A-5gyzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omm CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 GLY A 453
SER A 401
ILE A 446
LEU A 399
 None
 0.92A 1jg4A-5ommA:
undetectable		 1jg4A-5ommA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t38 EVDMO1

(Micromonospora
carbonacea) 		PF13847
(Methyltransf_31) 		4 GLU A  60
GLY A  62
GLU A  84
ASP A 111
 None
SAH  A 301 (-3.4A)
SAH  A 301 (-1.8A)
SAH  A 301 (-2.9A)
 0.76A 1jg4A-5t38A:
9.5		 1jg4A-5t38A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcp LIPOPROTEIN PRGK

(Salmonella
enterica) 		PF01514
(YscJ_FliF) 		4 GLY 0  26
ILE 0  58
LEU 0  24
ASP 0  50
 None
 0.92A 1jg4A-5tcp0:
undetectable		 1jg4A-5tcp0:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		4 GLY A  53
ARG A 327
LEU A 323
ASP A 331
 None
 0.86A 1jg4A-5tj3A:
undetectable		 1jg4A-5tj3A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		4 GLY A  87
ARG A  71
ILE A 430
ASP A 423
 FAD  A 501 (-3.9A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.6A)
None
 0.85A 1jg4A-5ts5A:
3.7		 1jg4A-5ts5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukp DH522.1 FAB FRAGMENT
HEAVY CHAIN

(Macaca mulatta) 		no annotation 4 GLY H  55
SER H  70
ILE H  29
ASP H  32
 None
 0.89A 1jg4A-5ukpH:
undetectable		 1jg4A-5ukpH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A 304
SER A 307
ILE A 268
ASP A 263
 None
 0.92A 1jg4A-5x5hA:
undetectable		 1jg4A-5x5hA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 GLU A 319
GLY A 318
GLU A 324
ILE A 359
ASP A 390
 MG  A1604 ( 4.3A)
None
None
None
None
 1.38A 1jg4A-5x7sA:
undetectable		 1jg4A-5x7sA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM

(Bacillus
subtilis) 		no annotation 4 GLU A  60
GLY A  62
GLU A  85
ASP A 113
 SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
 0.35A 1jg4A-5zw4A:
12.6		 1jg4A-5zw4A:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 4 GLY A 243
ARG A 245
ILE A 249
ASP A 276
 None
 0.84A 1jg4A-6bk7A:
undetectable		 1jg4A-6bk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA

(Escherichia
coli) 		no annotation 4 GLU A 375
GLY A 374
LEU A 370
ASP A 381
 None
 0.81A 1jg4A-6bogA:
undetectable		 1jg4A-6bogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cyz HOMOSERINE KINASE

(Mycobacteroides
abscessus) 		no annotation 4 GLU A  59
GLY A  56
SER A  97
ILE A  94
 None
None
ANP  A 401 (-2.8A)
None
 0.86A 1jg4A-6cyzA:
undetectable		 1jg4A-6cyzA:
undetectable