SIMILAR PATTERNS OF AMINO ACIDS FOR 1JDV_B_ADNB2260

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		6 ARG A  86
THR A  89
VAL A 179
GLU A 180
MET A 181
GLU A 182
 SO4  A 250 ( 3.1A)
SO4  A 250 ( 3.0A)
FMB  A 270 (-4.6A)
FMB  A 270 (-4.6A)
FMB  A 270 (-3.8A)
FMB  A 270 (-2.8A)
 0.63A 1jdvB-1jdzA:
42.2
1jdvC-1jdzA:
42.1		 1jdvB-1jdzA:
100.00
1jdvC-1jdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1odi PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermus
thermophilus) 		PF01048
(PNP_UDP_1) 		5 ARG A  87
THR A  90
GLU A 179
MET A 180
GLU A 181
 SO4  A1236 ( 2.8A)
SO4  A1236 ( 3.0A)
ADN  A1237 (-4.9A)
ADN  A1237 (-3.7A)
ADN  A1237 (-3.0A)
 0.34A 1jdvB-1odiA:
34.7
1jdvC-1odiA:
34.7		 1jdvB-1odiA:
40.42
1jdvC-1odiA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		6 ARG A  87
VAL A 178
GLU A 179
MET A 180
GLU A 181
ASP A 204
 PO4  A 309 ( 2.8A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 (-3.1A)
 0.35A 1jdvB-1pk9A:
33.7
1jdvC-1pk9A:
34.6		 1jdvB-1pk9A:
32.64
1jdvC-1pk9A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z34 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Trichomonas
vaginalis) 		PF01048
(PNP_UDP_1) 		6 ARG A  87
THR A  90
VAL A 178
GLU A 179
MET A 180
GLU A 181
 2FD  A 300 ( 4.5A)
2FD  A 300 (-4.2A)
2FD  A 300 (-4.7A)
None
2FD  A 300 (-3.7A)
2FD  A 300 (-2.8A)
 0.50A 1jdvB-1z34A:
33.9
1jdvC-1z34A:
19.4		 1jdvB-1z34A:
34.87
1jdvC-1z34A:
34.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Streptococcus
pneumoniae) 		PF01048
(PNP_UDP_1) 		5 VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-2.9A)
 0.74A 1jdvB-1zosA:
21.9
1jdvC-1zosA:
9.8		 1jdvB-1zosA:
24.81
1jdvC-1zosA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE

(Plasmodium
falciparum) 		PF01048
(PNP_UDP_1) 		5 ARG A  88
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.42A 1jdvB-2bsxA:
32.0
1jdvC-2bsxA:
31.8		 1jdvB-2bsxA:
29.30
1jdvC-2bsxA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		5 ARG A 137
THR A 140
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.30A 1jdvB-3bjeA:
28.4
1jdvC-3bjeA:
28.9		 1jdvB-3bjeA:
23.68
1jdvC-3bjeA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl6 5'-METHYLTHIOADENOSI
NE
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Staphylococcus
aureus) 		PF01048
(PNP_UDP_1) 		5 VAL A 170
GLU A 171
MET A 172
GLU A 173
ASP A 196
 FMC  A 229 ( 4.7A)
FMC  A 229 (-4.7A)
FMC  A 229 (-3.5A)
FMC  A 229 (-2.5A)
FMC  A 229 (-3.0A)
 0.55A 1jdvB-3bl6A:
24.3
1jdvC-3bl6A:
24.0		 1jdvB-3bl6A:
27.94
1jdvC-3bl6A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-2.9A)
 0.61A 1jdvB-3dp9A:
23.5
1jdvC-3dp9A:
23.3		 1jdvB-3dp9A:
24.90
1jdvC-3dp9A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		5 VAL A 175
GLU A 176
MET A 177
GLU A 178
ASP A 201
 MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.0A)
 0.56A 1jdvB-3eeiA:
23.2
1jdvC-3eeiA:
22.7		 1jdvB-3eeiA:
25.76
1jdvC-3eeiA:
25.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emv URIDINE
PHOSPHORYLASE,
PUTATIVE

(Plasmodium
vivax) 		PF01048
(PNP_UDP_1) 		5 ARG A  89
VAL A 182
GLU A 183
MET A 184
GLU A 185
 SO4  A 254 (-3.2A)
None
None
None
None
 0.34A 1jdvB-3emvA:
31.9
1jdvC-3emvA:
32.4		 1jdvB-3emvA:
30.08
1jdvC-3emvA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 ARG A 138
THR A 141
GLU A 248
MET A 249
GLU A 250
 PO4  A 401 (-3.0A)
PO4  A 401 ( 3.0A)
None
BAU  A 400 (-3.8A)
PO4  A 401 ( 4.2A)
 0.32A 1jdvB-3eufA:
24.6
1jdvC-3eufA:
25.1		 1jdvB-3eufA:
23.37
1jdvC-3eufA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3k UNCHARACTERIZED
PROTEIN YKR043C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		5 GLU A 139
GLU A 106
ASP A  95
HIS A 176
ARG A  69
 None
 1.32A 1jdvB-3f3kA:
undetectable
1jdvC-3f3kA:
undetectable		 1jdvB-3f3kA:
20.65
1jdvC-3f3kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvy URIDINE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		5 ARG A 137
THR A 140
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.29A 1jdvB-3kvyA:
24.8
1jdvC-3kvyA:
25.4		 1jdvB-3kvyA:
24.68
1jdvC-3kvyA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 ARG A 669
THR A 627
VAL A 624
GLU A 625
ASP A 593
 None
 1.27A 1jdvB-3ne5A:
undetectable
1jdvC-3ne5A:
undetectable		 1jdvB-3ne5A:
12.56
1jdvC-3ne5A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-2.9A)
 0.46A 1jdvB-3o4vA:
23.1
1jdvC-3o4vA:
22.9		 1jdvB-3o4vA:
26.36
1jdvC-3o4vA:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		6 ARG A 101
VAL A 192
GLU A 193
MET A 194
GLU A 195
ASP A 218
 PO4  A 501 (-2.8A)
DIH  A 500 (-4.8A)
None
DIH  A 500 (-3.8A)
DIH  A 500 (-2.9A)
DIH  A 500 (-3.1A)
 0.51A 1jdvB-3of3A:
32.5
1jdvC-3of3A:
33.0		 1jdvB-3of3A:
30.77
1jdvC-3of3A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 ARG A 144
THR A 147
GLU A 254
MET A 255
GLU A 256
 None
BAU  A 400 (-4.5A)
None
BAU  A 400 (-3.9A)
None
 0.31A 1jdvB-3p0fA:
24.2
1jdvC-3p0fA:
24.6		 1jdvB-3p0fA:
26.60
1jdvC-3p0fA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qpb URIDINE
PHOSPHORYLASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		5 ARG A  94
THR A  97
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.32A 1jdvB-3qpbA:
31.6
1jdvC-3qpbA:
31.3		 1jdvB-3qpbA:
31.29
1jdvC-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsj NUDIX HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF00293
(NUDIX) 		5 ARG A  78
GLU A 170
GLU A  82
GLU A  79
ARG A   5
 None
GOL  A 232 (-3.5A)
None
CA  A 230 (-3.3A)
None
 1.31A 1jdvB-3qsjA:
undetectable
1jdvC-3qsjA:
undetectable		 1jdvB-3qsjA:
19.92
1jdvC-3qsjA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tl6 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Entamoeba
histolytica) 		PF01048
(PNP_UDP_1) 		5 ARG A  92
GLU A 183
MET A 184
GLU A 185
ASP A 208
 SO4  A 239 (-3.2A)
None
None
SO4  A 239 ( 4.4A)
None
 0.68A 1jdvB-3tl6A:
33.2
1jdvC-3tl6A:
33.3		 1jdvB-3tl6A:
34.57
1jdvC-3tl6A:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tl6 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Entamoeba
histolytica) 		PF01048
(PNP_UDP_1) 		5 ARG A  92
VAL A 182
GLU A 183
MET A 184
GLU A 185
 SO4  A 239 (-3.2A)
None
None
None
SO4  A 239 ( 4.4A)
 0.19A 1jdvB-3tl6A:
33.2
1jdvC-3tl6A:
33.3		 1jdvB-3tl6A:
34.57
1jdvC-3tl6A:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uav PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus cereus) 		PF01048
(PNP_UDP_1) 		6 ARG A  87
THR A  90
VAL A 178
GLU A 179
MET A 180
GLU A 181
 SO4  A 236 (-2.7A)
SO4  A 236 (-3.0A)
None
None
None
SO4  A 236 ( 4.4A)
 0.36A 1jdvB-3uavA:
17.8
1jdvC-3uavA:
34.6		 1jdvB-3uavA:
36.25
1jdvC-3uavA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus
subtilis) 		PF01048
(PNP_UDP_1) 		6 ARG A  87
VAL A 177
GLU A 178
MET A 179
GLU A 180
ASP A 203
 None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-4.1A)
 0.54A 1jdvB-4daoA:
33.0
1jdvC-4daoA:
33.8		 1jdvB-4daoA:
31.01
1jdvC-4daoA:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 ARG A  88
GLU A 180
MET A 181
GLU A 182
ASP A 205
 PO4  A 301 (-2.9A)
None
None
PO4  A 301 ( 4.7A)
None
 0.82A 1jdvB-4ldnA:
34.2
1jdvC-4ldnA:
34.9		 1jdvB-4ldnA:
31.00
1jdvC-4ldnA:
31.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 ARG A  88
VAL A 179
GLU A 180
MET A 181
GLU A 182
 PO4  A 301 (-2.9A)
None
None
None
PO4  A 301 ( 4.7A)
 0.42A 1jdvB-4ldnA:
34.2
1jdvC-4ldnA:
34.9		 1jdvB-4ldnA:
31.00
1jdvC-4ldnA:
31.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber) 		PF01048
(PNP_UDP_1) 		5 THR A  90
VAL A 178
GLU A 179
MET A 180
GLU A 181
 None
 0.44A 1jdvB-4m3nA:
34.4
1jdvC-4m3nA:
35.4		 1jdvB-4m3nA:
32.57
1jdvC-4m3nA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7w PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Leptotrichia
buccalis) 		PF01048
(PNP_UDP_1) 		7 ARG A  88
THR A  91
VAL A 179
GLU A 180
MET A 181
GLU A 182
ASP A 205
 PO4  A 400 (-3.0A)
PO4  A 400 (-3.5A)
None
None
None
PO4  A 400 ( 4.4A)
None
 0.38A 1jdvB-4m7wA:
34.7
1jdvC-4m7wA:
35.7		 1jdvB-4m7wA:
32.21
1jdvC-4m7wA:
32.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qez 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Bacillus
anthracis) 		no annotation 5 VAL B 172
GLU B 173
MET B 174
GLU B 175
ASP B 198
 None
TRS  B 302 ( 4.8A)
TRS  B 302 (-4.2A)
TRS  B 302 (-2.7A)
ADE  B 301 (-2.4A)
 0.68A 1jdvB-4qezB:
22.1
1jdvC-4qezB:
21.9		 1jdvB-4qezB:
23.91
1jdvC-4qezB:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		5 ARG A  88
THR A  91
GLU A 193
MET A 194
GLU A 195
 SO4  A 302 ( 2.8A)
SO4  A 302 ( 3.0A)
GOL  A 303 (-4.9A)
GOL  A 303 (-3.5A)
GOL  A 303 (-2.9A)
 0.29A 1jdvB-4r2wA:
31.1
1jdvC-4r2wA:
30.8		 1jdvB-4r2wA:
33.85
1jdvC-4r2wA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tym PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Streptococcus
agalactiae) 		PF01048
(PNP_UDP_1) 		5 ARG A 109
THR A 112
GLU A 201
MET A 202
GLU A 203
 SO4  A 301 (-2.8A)
SO4  A 301 (-3.7A)
None
None
SO4  A 301 ( 4.4A)
 0.51A 1jdvB-4tymA:
21.6
1jdvC-4tymA:
35.2		 1jdvB-4tymA:
30.38
1jdvC-4tymA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tym PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Streptococcus
agalactiae) 		PF01048
(PNP_UDP_1) 		5 ARG A 109
THR A 112
MET A 202
GLU A 203
ASP A 226
 SO4  A 301 (-2.8A)
SO4  A 301 (-3.7A)
None
SO4  A 301 ( 4.4A)
None
 0.85A 1jdvB-4tymA:
21.6
1jdvC-4tymA:
35.2		 1jdvB-4tymA:
30.38
1jdvC-4tymA:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyf PUTATIVE URIDINE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		5 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.31A 1jdvB-5cyfA:
23.6
1jdvC-5cyfA:
6.5		 1jdvB-5cyfA:
25.58
1jdvC-5cyfA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk6 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Colwellia
psychrerythraea) 		PF01048
(PNP_UDP_1) 		5 VAL A 177
GLU A 178
MET A 179
GLU A 180
ASP A 203
 ADE  A 302 (-4.6A)
None
ADE  A 302 (-4.1A)
None
ADE  A 302 (-2.9A)
 0.51A 1jdvB-5dk6A:
22.0
1jdvC-5dk6A:
21.7		 1jdvB-5dk6A:
23.90
1jdvC-5dk6A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		5 ARG A  41
VAL A 405
GLU A 406
GLU A 205
ARG A 304
 None
 1.12A 1jdvB-5fjnA:
undetectable
1jdvC-5fjnA:
undetectable		 1jdvB-5fjnA:
20.61
1jdvC-5fjnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE

(Helicobacter
pylori) 		PF01048
(PNP_UDP_1) 		5 VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 (-2.2A)
 0.36A 1jdvB-5k1zA:
23.8
1jdvC-5k1zA:
23.3		 1jdvB-5k1zA:
23.27
1jdvC-5k1zA:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 ARG A  90
THR A  93
GLU A 195
MET A 196
GLU A 197
 SO4  A 301 ( 3.0A)
SO4  A 301 ( 2.9A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
URI  A 303 (-2.7A)
 0.28A 1jdvB-5lhvA:
31.4
1jdvC-5lhvA:
32.0		 1jdvB-5lhvA:
31.27
1jdvC-5lhvA:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue1 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 None
TRS  A 302 ( 4.6A)
TRS  A 302 (-3.9A)
TRS  A 302 (-2.7A)
9DA  A 301 (-2.8A)
 0.67A 1jdvB-5ue1A:
23.6
1jdvC-5ue1A:
23.4		 1jdvB-5ue1A:
26.79
1jdvC-5ue1A:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g7x -

(-) 		no annotation 5 ARG A  87
THR A  90
GLU A 179
MET A 180
GLU A 181
 PO4  A 304 ( 4.4A)
PO4  A 304 (-2.8A)
None
IMD  A 302 (-4.6A)
PO4  A 304 ( 4.7A)
 0.29A 1jdvB-6g7xA:
34.6
1jdvC-6g7xA:
35.5		 1jdvB-6g7xA:
undetectable
1jdvC-6g7xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g7x -

(-) 		no annotation 5 ARG A  87
THR A  90
MET A 180
GLU A 181
ASP A 204
 PO4  A 304 ( 4.4A)
PO4  A 304 (-2.8A)
IMD  A 302 (-4.6A)
PO4  A 304 ( 4.7A)
None
 0.95A 1jdvB-6g7xA:
34.6
1jdvC-6g7xA:
35.5		 1jdvB-6g7xA:
undetectable
1jdvC-6g7xA:
undetectable