SIMILAR PATTERNS OF AMINO ACIDS FOR 1J96_A_TESA903_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 TYR A  64
VAL A  89
ILE A  88
LEU A  70
 None
 1.32A 1j96A-1amyA:
9.1		 1j96A-1amyA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 TYR A  76
VAL B 378
ILE B 377
LEU B 415
 None
 1.02A 1j96A-1e1hA:
undetectable		 1j96A-1e1hA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		4 TRP A 190
VAL A 163
ILE A 162
LEU A  83
 None
 1.32A 1j96A-1ehkA:
undetectable		 1j96A-1ehkA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 TYR A 276
TRP A 134
ILE A 130
LEU A 262
 None
 1.14A 1j96A-1guqA:
undetectable		 1j96A-1guqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		4 TRP A 126
VAL A 123
ILE A 384
LEU A 251
 None
 1.27A 1j96A-1izoA:
undetectable		 1j96A-1izoA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR A 249
TRP A 174
VAL A 111
ILE A 114
 None
 1.28A 1j96A-1llaA:
undetectable		 1j96A-1llaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		4 TYR A 556
VAL A 574
ILE A 578
LEU A 504
 None
 1.27A 1j96A-1m9iA:
undetectable		 1j96A-1m9iA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn6 POLYKETIDE SYNTHASE
IV

(Streptomyces
venezuelae) 		PF00975
(Thioesterase) 		4 TRP A 255
VAL A 232
ILE A 172
LEU A 220
 None
 1.27A 1j96A-1mn6A:
undetectable		 1j96A-1mn6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		4 TYR A 171
VAL A 268
ILE A 271
LEU A 179
 None
 1.20A 1j96A-1rh9A:
10.3		 1j96A-1rh9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tie ERYTHRINA TRYPSIN
INHIBITOR

(Erythrina
caffra) 		PF00197
(Kunitz_legume) 		4 VAL A 156
ILE A 142
TRP A  89
LEU A  31
 None
 0.98A 1j96A-1tieA:
undetectable		 1j96A-1tieA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1

(Mus musculus) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		4 TYR A 419
VAL A 286
ILE A 336
LEU A 321
 None
 1.24A 1j96A-1xhbA:
undetectable		 1j96A-1xhbA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm7 HYPOTHETICAL PROTEIN
AQ_1665

(Aquifex
aeolicus) 		PF12850
(Metallophos_2) 		4 VAL A 169
ILE A   5
TRP A  65
LEU A  86
 None
 1.17A 1j96A-1xm7A:
undetectable		 1j96A-1xm7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7s HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		4 TRP 2  78
VAL 2  69
ILE 2 249
LEU 2 234
 None
 1.27A 1j96A-1z7s2:
undetectable		 1j96A-1z7s2:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 VAL A 411
ILE A 414
TRP A 354
LEU A 253
 None
 1.19A 1j96A-1zr6A:
undetectable		 1j96A-1zr6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuw GLUTAMATE RACEMASE 1

(Bacillus
subtilis) 		PF01177
(Asp_Glu_race) 		4 TYR A 188
VAL A  96
ILE A  97
LEU A 181
 None
 1.08A 1j96A-1zuwA:
undetectable		 1j96A-1zuwA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 TYR A 143
VAL A 136
ILE A 135
LEU A 156
 None
 0.84A 1j96A-2cvtA:
2.9		 1j96A-2cvtA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czr TBP-INTERACTING
PROTEIN

(Thermococcus
kodakarensis) 		PF15517
(TBPIP_N) 		4 TYR A 147
TRP A 102
VAL A 119
LEU A 172
 None
 1.31A 1j96A-2czrA:
undetectable		 1j96A-2czrA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		4 TYR A 229
VAL A  95
ILE A  99
LEU A 194
 None
 1.17A 1j96A-2f6dA:
undetectable		 1j96A-2f6dA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 VAL A 289
ILE A 254
TRP A 302
LEU A 319
 None
 1.25A 1j96A-2g3nA:
3.0		 1j96A-2g3nA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 TYR A  80
VAL A 208
ILE A 207
LEU A 277
 None
 0.94A 1j96A-2gb3A:
undetectable		 1j96A-2gb3A:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 TRP A  86
VAL A 128
ILE A 129
TRP A 227
LEU A 306
 None
None
None
FFA  A 325 (-3.8A)
FFA  A 325 (-4.8A)
 0.56A 1j96A-2ipjA:
55.9		 1j96A-2ipjA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6x GREEN-LIGHT
ABSORBING
PROTEORHODOPSIN

(uncultured
marine gamma
proteobacterium
EBAC31A08) 		PF01036
(Bac_rhodopsin) 		4 TYR A 110
VAL A 241
ILE A 237
LEU A 105
 None
 1.20A 1j96A-2l6xA:
undetectable		 1j96A-2l6xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nck NUCLEOSIDE
DIPHOSPHATE KINASE

(Myxococcus
xanthus) 		no annotation 4 TYR R 131
VAL R  64
ILE R  68
LEU R  74
 None
 1.32A 1j96A-2nckR:
undetectable		 1j96A-2nckR:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 TYR A  77
VAL A 379
ILE A 378
LEU A 416
 None
 1.15A 1j96A-2nz9A:
undetectable		 1j96A-2nz9A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 TYR A 389
VAL A 369
ILE A 372
LEU A 235
 None
 0.99A 1j96A-2odpA:
undetectable		 1j96A-2odpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB

(Escherichia
coli) 		PF03888
(MucB_RseB)
PF17188
(MucB_RseB_C) 		4 TYR A 254
VAL A 265
ILE A 294
LEU A 300
 None
 1.21A 1j96A-2p4bA:
undetectable		 1j96A-2p4bA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plg TLL0839 PROTEIN

(Synechococcus
elongatus) 		PF10722
(YbjN) 		4 TRP A  52
VAL A  43
ILE A  51
LEU A 123
 None
 1.24A 1j96A-2plgA:
undetectable		 1j96A-2plgA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		4 VAL A 148
ILE A 103
TRP A 228
LEU A 230
 None
 1.25A 1j96A-2pv7A:
undetectable		 1j96A-2pv7A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 159
VAL A  97
ILE A  98
LEU A 109
 None
 1.07A 1j96A-2qriA:
undetectable		 1j96A-2qriA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 TYR A 137
VAL A 159
ILE A 160
LEU A 301
 None
 1.32A 1j96A-2veaA:
undetectable		 1j96A-2veaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8r GLYCOSYL HYDROLASE

(Aspergillus
fumigatus) 		PF01183
(Glyco_hydro_25) 		4 VAL A 124
ILE A 127
TRP A 184
LEU A 169
 None
 1.11A 1j96A-2x8rA:
4.0		 1j96A-2x8rA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xb0 CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF13921
(Myb_DNA-bind_6) 		4 TRP X 191
ILE X 206
TRP X 171
LEU X 256
 None
 1.32A 1j96A-2xb0X:
undetectable		 1j96A-2xb0X:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		4 TYR A 665
TRP A 114
ILE A 110
LEU A 610
 None
 1.31A 1j96A-2z87A:
undetectable		 1j96A-2z87A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A 718
VAL A 730
ILE A 727
LEU A 659
 None
 0.97A 1j96A-2znsA:
undetectable		 1j96A-2znsA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA
NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		4 TYR B 145
VAL A 106
ILE A 107
LEU A 111
 None
 1.14A 1j96A-2zpbB:
undetectable		 1j96A-2zpbB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		4 TYR A 122
VAL A 168
ILE A 195
LEU A 158
 None
 0.82A 1j96A-3b8bA:
undetectable		 1j96A-3b8bA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dse BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 TYR A  77
VAL A 379
ILE A 378
LEU A 416
 None
 1.08A 1j96A-3dseA:
undetectable		 1j96A-3dseA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 VAL A 324
ILE A 325
TRP A 254
LEU A 217
 None
 1.29A 1j96A-3e53A:
undetectable		 1j96A-3e53A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 TRP 2  78
VAL 2  69
ILE 2 248
LEU 2 233
 None
 1.27A 1j96A-3epf2:
undetectable		 1j96A-3epf2:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 VAL A  14
ILE A  19
TRP A  44
LEU A 154
 None
 1.30A 1j96A-3fiiA:
undetectable		 1j96A-3fiiA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpk FERREDOXIN-NADP
REDUCTASE

(Salmonella
enterica) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 TYR A 121
VAL A 185
ILE A 189
LEU A 109
 None
 1.27A 1j96A-3fpkA:
undetectable		 1j96A-3fpkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 TYR A4231
VAL A4118
ILE A4251
LEU A4223
 None
 1.31A 1j96A-3g1nA:
undetectable		 1j96A-3g1nA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Shewanella
denitrificans) 		PF01380
(SIS) 		4 TYR A 306
VAL A 258
ILE A 260
LEU A 185
 None
 1.04A 1j96A-3hbaA:
undetectable		 1j96A-3hbaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijd UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF02219
(MTHFR) 		4 TYR A  78
VAL A 284
ILE A 289
LEU A  49
 None
C2F  A 315 (-4.1A)
C2F  A 315 (-4.5A)
None
 1.12A 1j96A-3ijdA:
9.6		 1j96A-3ijdA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilr HEPARIN LYASE I

(Bacteroides
thetaiotaomicron) 		PF14099
(Polysacc_lyase) 		4 TYR A 280
VAL A 133
ILE A 135
LEU A 237
 None
 1.25A 1j96A-3ilrA:
undetectable		 1j96A-3ilrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kci PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		4 VAL A4037
ILE A4039
TRP A4063
LEU A4071
 None
 1.13A 1j96A-3kciA:
undetectable		 1j96A-3kciA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp5 PUTATIVE CELL
SURFACE HYDROLASE

(Lactobacillus
plantarum) 		PF06028
(DUF915) 		4 TYR A 118
TRP A 111
VAL A   9
ILE A  64
 None
 1.21A 1j96A-3lp5A:
undetectable		 1j96A-3lp5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mst PUTATIVE NITRATE
TRANSPORT PROTEIN

(Thermoplasma
volcanium) 		PF12916
(DUF3834) 		4 TYR A 211
VAL A  97
ILE A  73
LEU A 136
 None
EDO  A 235 (-3.9A)
None
None
 1.21A 1j96A-3mstA:
undetectable		 1j96A-3mstA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3out GLUTAMATE RACEMASE

(Francisella
tularensis) 		PF01177
(Asp_Glu_race) 		4 TYR A 186
VAL A  97
ILE A  98
LEU A 179
 None
 1.11A 1j96A-3outA:
undetectable		 1j96A-3outA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A1379
VAL A1474
ILE A1473
LEU A1418
 None
 0.92A 1j96A-3va7A:
undetectable		 1j96A-3va7A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 TYR A  96
VAL A 153
ILE A 126
LEU A 104
 None
 1.15A 1j96A-3vz0A:
undetectable		 1j96A-3vz0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 VAL A 239
ILE A 240
TRP A 320
LEU A 360
 None
 1.26A 1j96A-3wfoA:
undetectable		 1j96A-3wfoA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(Aquifex
aeolicus;
synthetic
construct) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 VAL A 239
ILE A 240
TRP A 320
LEU A 360
 None
 1.25A 1j96A-3wfpA:
undetectable		 1j96A-3wfpA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 TYR A  77
VAL A 379
ILE A 378
LEU A 416
 None
 1.11A 1j96A-3zusA:
undetectable		 1j96A-3zusA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4c CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 4 TRP A1273
ILE A1288
TRP A1253
LEU A1309
 None
 1.30A 1j96A-4b4cA:
undetectable		 1j96A-4b4cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TYR A 583
VAL A 548
ILE A 549
LEU A 759
 None
 1.32A 1j96A-4bziA:
undetectable		 1j96A-4bziA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 TYR A 216
VAL A 270
ILE A 313
LEU A 253
 None
 1.22A 1j96A-4cpnA:
undetectable		 1j96A-4cpnA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		4 TYR A 152
VAL A  97
ILE A  92
LEU A 157
 None
 1.18A 1j96A-4e3aA:
2.9		 1j96A-4e3aA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exo METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Vibrio
parahaemolyticus) 		PF17200
(sCache_2) 		4 TYR A  66
VAL A 101
ILE A 102
LEU A  78
 PYR  A 201 (-4.4A)
None
None
None
 1.32A 1j96A-4exoA:
undetectable		 1j96A-4exoA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 TYR A  70
VAL A 100
ILE A 185
LEU A  34
 None
 1.13A 1j96A-4eziA:
undetectable		 1j96A-4eziA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd9 BETA/GAMMA
CRYSTALLIN
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		PF00030
(Crystall) 		4 VAL A  27
ILE A  24
TRP A  50
LEU A  89
 None
 1.14A 1j96A-4fd9A:
undetectable		 1j96A-4fd9A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		4 TYR A 620
VAL A 562
ILE A 564
LEU A 557
 None
 1.15A 1j96A-4ft2A:
undetectable		 1j96A-4ft2A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvs PUTATIVE LIPOPROTEIN

(Parabacteroides
distasonis) 		no annotation 4 TYR A 185
VAL A 144
ILE A 117
LEU A 212
 None
 1.12A 1j96A-4fvsA:
undetectable		 1j96A-4fvsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		4 TYR B 301
TRP B 191
ILE B 380
LEU B 343
 None
XYP  B 802 (-4.2A)
None
None
 1.21A 1j96A-4g68B:
undetectable		 1j96A-4g68B:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hde SCO1/SENC FAMILY
LIPOPROTEIN

(Bacillus
anthracis) 		PF02630
(SCO1-SenC) 		4 TYR A 163
VAL A 101
ILE A 136
LEU A  37
 None
 1.04A 1j96A-4hdeA:
undetectable		 1j96A-4hdeA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc5 TRANSMEMBRANE
PROTEIN 173

(Mus musculus) 		PF15009
(TMEM173) 		4 TYR A 162
VAL A 312
ILE A 311
LEU A 171
 None
 1.13A 1j96A-4jc5A:
undetectable		 1j96A-4jc5A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		4 TYR A  83
VAL A 140
ILE A 135
LEU A  91
 None
 1.20A 1j96A-4k2nA:
undetectable		 1j96A-4k2nA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		4 TYR A 327
VAL A 456
ILE A 459
LEU A 483
 NM2  A 601 (-4.4A)
None
None
None
 1.21A 1j96A-4m8jA:
undetectable		 1j96A-4m8jA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mem UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11

(Rattus
norvegicus) 		PF06337
(DUSP)
PF14836
(Ubiquitin_3) 		4 TYR A 104
VAL A 132
ILE A 133
LEU A  94
 None
 1.25A 1j96A-4memA:
undetectable		 1j96A-4memA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv4 SIGNAL PEPTIDASE I

(Bacillus
anthracis) 		PF00717
(Peptidase_S24) 		4 TYR A 109
VAL A 100
ILE A  91
LEU A 122
 None
 1.13A 1j96A-4nv4A:
undetectable		 1j96A-4nv4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1

(Homo sapiens) 		PF00415
(RCC1) 		4 VAL A4291
ILE A4293
TRP A4315
LEU A4323
 None
 1.07A 1j96A-4o2wA:
undetectable		 1j96A-4o2wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF02112
(PDEase_II) 		4 VAL A 322
ILE A 276
TRP A 261
LEU A 310
 None
 0.98A 1j96A-4ojxA:
undetectable		 1j96A-4ojxA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		4 TYR A 623
VAL A 539
ILE A 538
LEU A 633
 None
 1.19A 1j96A-4ru4A:
undetectable		 1j96A-4ru4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcx BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED

(Thermoanaerobacter
italicus) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 TYR A 237
VAL A 322
ILE A 325
LEU A  51
 None
 1.16A 1j96A-4wcxA:
5.5		 1j96A-4wcxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yd8 PROTEIN PTHB1

(Homo sapiens) 		PF14727
(PHTB1_N) 		4 VAL A 335
ILE A 345
TRP A 322
LEU A 320
 None
 1.21A 1j96A-4yd8A:
undetectable		 1j96A-4yd8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4za3 RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00652
(Ricin_B_lectin) 		4 VAL B 202
ILE B 203
TRP B 172
LEU B 174
 None
 1.13A 1j96A-4za3B:
undetectable		 1j96A-4za3B:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 VAL A 350
ILE A 351
TRP A 358
LEU A 534
 None
 1.10A 1j96A-5a22A:
undetectable		 1j96A-5a22A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bni UNCHARACTERIZED
PROTEIN

(Sus scrofa) 		PF02267
(Rib_hydrolayse) 		4 VAL A 246
ILE A 247
TRP A 130
LEU A 147
 None
 1.21A 1j96A-5bniA:
undetectable		 1j96A-5bniA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4w PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 TYR A 337
VAL A 294
ILE A 329
LEU A 355
 None
 0.97A 1j96A-5d4wA:
undetectable		 1j96A-5d4wA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtb CG3822

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A 192
VAL A 204
ILE A 201
LEU A 131
 None
 0.93A 1j96A-5dtbA:
undetectable		 1j96A-5dtbA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6

(Arabidopsis
thaliana) 		PF00808
(CBFD_NFYB_HMF) 		4 TYR A  97
VAL A  68
ILE A  71
LEU A 138
 None
 1.21A 1j96A-5g49A:
undetectable		 1j96A-5g49A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17

(Sphingomonas
sp. PAMC 26605) 		PF00067
(p450) 		4 TYR A  48
VAL A   7
ILE A   8
LEU A  31
 None
 0.91A 1j96A-5h1zA:
undetectable		 1j96A-5h1zA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 4 TYR A 419
VAL A 393
ILE A 374
LEU A 383
 None
 1.28A 1j96A-5hdtA:
undetectable		 1j96A-5hdtA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A1379
VAL A1474
ILE A1473
LEU A1418
 None
 0.93A 1j96A-5i8iA:
undetectable		 1j96A-5i8iA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		4 TYR A 301
VAL A 210
ILE A 209
LEU A 257
 None
 1.22A 1j96A-5ikzA:
5.6		 1j96A-5ikzA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irb RTX-ADHESIN

(Marinomonas
primoryensis) 		no annotation 4 TRP A 350
VAL A 321
ILE A 295
LEU A 339
 None
 1.15A 1j96A-5irbA:
undetectable		 1j96A-5irbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		4 TYR A  13
VAL A 216
ILE A 256
LEU A 260
 None
 1.29A 1j96A-5kkgA:
2.4		 1j96A-5kkgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		4 TYR A 417
VAL A 447
ILE A 452
LEU A  17
 None
 1.27A 1j96A-5kojA:
undetectable		 1j96A-5kojA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00499
(Oxidored_q3)
PF06444
(NADH_dehy_S2_C) 		4 TRP N  84
VAL N  74
ILE N  75
LEU J  52
 None
 1.05A 1j96A-5lc5N:
undetectable		 1j96A-5lc5N:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 VAL A1458
ILE A1457
TRP A1419
LEU A1502
 None
 1.32A 1j96A-5m59A:
undetectable		 1j96A-5m59A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 4 TRP A 551
VAL A 547
ILE A 548
LEU A 448
 None
 1.04A 1j96A-5mpmA:
undetectable		 1j96A-5mpmA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n56 SUPEROXIDE DISMUTASE
[MN/FE] 1

(Staphylococcus
aureus) 		no annotation 4 VAL A  99
ILE A 102
TRP A 183
LEU A 160
 None
 1.05A 1j96A-5n56A:
undetectable		 1j96A-5n56A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohq TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Homo sapiens) 		no annotation 4 VAL A1007
ILE A1004
TRP A 979
LEU A1045
 None
 1.31A 1j96A-5ohqA:
undetectable		 1j96A-5ohqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4p 26S PROTEASOME
REGULATORY SUBUNIT
RPN8

(Saccharomyces
cerevisiae) 		PF01398
(JAB) 		4 VAL A 123
ILE A 122
TRP A  92
LEU A  68
 None
 1.08A 1j96A-5u4pA:
undetectable		 1j96A-5u4pA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		4 TYR A 402
VAL A 327
ILE A 323
LEU A 360
 None
 1.20A 1j96A-5vewA:
undetectable		 1j96A-5vewA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		4 VAL A 350
ILE A 399
TRP A 418
LEU A 384
 None
 1.16A 1j96A-5xgsA:
undetectable		 1j96A-5xgsA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z73 ALR0819 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 4 TYR A 153
VAL A 225
ILE A 228
LEU A 139
 None
 1.02A 1j96A-5z73A:
undetectable		 1j96A-5z73A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 4 TYR A 617
VAL A 554
ILE A 558
LEU A 666
 None
 1.11A 1j96A-6bbjA:
undetectable		 1j96A-6bbjA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 4 TYR A  50
VAL A 216
ILE A 454
LEU A 189
 None
 1.21A 1j96A-6c4gA:
undetectable		 1j96A-6c4gA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8g TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 4 TYR A 617
VAL A 554
ILE A 558
LEU A 666
 None
 1.10A 1j96A-6c8gA:
undetectable		 1j96A-6c8gA:
13.40