SIMILAR PATTERNS OF AMINO ACIDS FOR 1J8U_A_H4BA429_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		4 LEU A2004
SER A2006
PHE A2009
LEU A2010
 None
 0.41A 1j8uA-1914A:
undetectable		 1j8uA-1914A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL A 256
LEU A 214
SER A 216
LEU A 219
 None
 0.64A 1j8uA-1bdgA:
undetectable		 1j8uA-1bdgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		4 VAL A 285
LEU A 239
LEU A 218
ALA A 371
 None
 0.89A 1j8uA-1c3rA:
0.0		 1j8uA-1c3rA:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		5 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
 0.68A 1j8uA-1dmwA:
55.0		 1j8uA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		6 VAL A 245
LEU A 249
SER A 251
PHE A 254
LEU A 255
ALA A 322
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
HBI  A 700 (-3.6A)
 0.13A 1j8uA-1dmwA:
55.0		 1j8uA-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 VAL A 837
LEU A 819
LEU A 828
ALA A 890
 None
 0.85A 1j8uA-1hn0A:
undetectable		 1j8uA-1hn0A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 VAL A 438
LEU A 443
LEU A 444
PHE A 400
 None
 0.85A 1j8uA-1hplA:
undetectable		 1j8uA-1hplA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		4 VAL A  40
LEU A 245
SER A 243
LEU A 240
 None
 0.65A 1j8uA-1ktnA:
undetectable		 1j8uA-1ktnA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lhu SEX HORMONE-BINDING
GLOBULIN

(Homo sapiens) 		PF00054
(Laminin_G_1) 		4 VAL A  89
LEU A 124
SER A 111
LEU A 113
 None
 0.89A 1j8uA-1lhuA:
undetectable		 1j8uA-1lhuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		4 VAL A  98
LEU A 101
PHE A 107
ALA A 176
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.2A)
 0.84A 1j8uA-1ltzA:
28.1		 1j8uA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 VAL A 158
LEU A 172
SER A 154
PHE A 153
 None
 0.89A 1j8uA-1n76A:
undetectable		 1j8uA-1n76A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		4 VAL A 190
LEU A 236
SER A 234
LEU A 243
 None
 0.89A 1j8uA-1nxzA:
undetectable		 1j8uA-1nxzA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		7 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
ALA A 322
 None
 0.68A 1j8uA-1phzA:
48.7		 1j8uA-1phzA:
95.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 VAL A 171
LEU A 162
SER A 158
PHE A 157
 None
 0.67A 1j8uA-1pyfA:
undetectable		 1j8uA-1pyfA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 VAL B  74
LEU B 276
LEU B 273
ALA E 282
 None
 0.83A 1j8uA-1skyB:
undetectable		 1j8uA-1skyB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufn PUTATIVE NUCLEAR
PROTEIN HOMOLOG
5830484A20RIK

(Mus musculus) 		PF01342
(SAND) 		4 VAL A  70
LEU A  56
PHE A  55
LEU A  50
 None
 0.88A 1j8uA-1ufnA:
undetectable		 1j8uA-1ufnA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 LEU A1016
LEU A1015
PHE A 963
ALA A1027
 None
None
HG  A2132 (-2.6A)
None
 0.87A 1j8uA-1urjA:
undetectable		 1j8uA-1urjA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		5 VAL A 264
LEU A 303
PHE A 304
LEU A 308
ALA A 338
 None
 1.30A 1j8uA-1vpeA:
undetectable		 1j8uA-1vpeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 VAL A 725
LEU A 736
LEU A 759
ALA A 753
 None
 0.70A 1j8uA-1we5A:
undetectable		 1j8uA-1we5A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		4 LEU A 243
SER A 241
PHE A 242
ALA A 235
 None
 0.71A 1j8uA-1yyaA:
undetectable		 1j8uA-1yyaA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01380
(SIS) 		4 VAL A 147
LEU A 223
SER A 225
LEU A 229
 None
 0.87A 1j8uA-2a3nA:
undetectable		 1j8uA-2a3nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00121
(TIM) 		4 LEU A 243
SER A 241
PHE A 242
ALA A 235
 None
 0.67A 1j8uA-2btmA:
undetectable		 1j8uA-2btmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlx UBX
DOMAIN-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF13899
(Thioredoxin_7) 		4 VAL A 105
LEU A 122
PHE A 127
LEU A 128
 None
 0.56A 1j8uA-2dlxA:
undetectable		 1j8uA-2dlxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		no annotation 4 VAL A 775
LEU A 569
SER A 565
LEU A 557
 None
 0.77A 1j8uA-2faqA:
undetectable		 1j8uA-2faqA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		4 LEU A 319
SER A 321
PHE A 324
LEU A 325
 None
 0.66A 1j8uA-2j0wA:
undetectable		 1j8uA-2j0wA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob5 HYPOTHETICAL PROTEIN
ATU2016

(Agrobacterium
fabrum) 		PF05025
(RbsD_FucU) 		4 VAL A  44
LEU A  48
LEU A   9
ALA A  61
 None
 0.86A 1j8uA-2ob5A:
undetectable		 1j8uA-2ob5A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 148
LEU A 161
SER A  97
ALA A  76
 None
 0.68A 1j8uA-2q5oA:
undetectable		 1j8uA-2q5oA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 VAL A 291
LEU A 294
LEU A 295
LEU A 301
 HBI  A 500 ( 4.6A)
HBI  A 500 (-4.7A)
HBI  A 500 (-4.2A)
MTY  A 300 ( 4.2A)
 0.53A 1j8uA-2tohA:
48.7		 1j8uA-2tohA:
59.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 VAL A 196
LEU A 258
PHE A 265
ALA A 343
 None
 0.75A 1j8uA-2wdaA:
undetectable		 1j8uA-2wdaA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 151
LEU A 164
SER A  98
ALA A  77
 None
 0.89A 1j8uA-2wvgA:
undetectable		 1j8uA-2wvgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 VAL A 247
LEU A 168
LEU A 214
ALA A 219
 None
 0.64A 1j8uA-2yp1A:
undetectable		 1j8uA-2yp1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 VAL A 367
LEU A  75
LEU A  72
ALA A 650
 None
 0.88A 1j8uA-2yr5A:
undetectable		 1j8uA-2yr5A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN-TYPE

(Toxoplasma
gondii) 		PF00160
(Pro_isomerase) 		4 VAL A 171
LEU A  35
SER A  33
PHE A  34
 None
 0.63A 1j8uA-3bo7A:
undetectable		 1j8uA-3bo7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		4 LEU A 428
SER A 426
LEU A 430
ALA A 444
 None
 0.86A 1j8uA-3djaA:
undetectable		 1j8uA-3djaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		4 VAL A 284
LEU A 151
PHE A 158
LEU A 138
 None
 0.87A 1j8uA-3fxbA:
undetectable		 1j8uA-3fxbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 LEU A 348
LEU A 351
PHE A 318
ALA A 315
 None
 0.62A 1j8uA-3gcwA:
undetectable		 1j8uA-3gcwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge6 NITROREDUCTASE

(Exiguobacterium
sibiricum) 		PF00881
(Nitroreductase) 		4 VAL A 184
LEU A 138
SER A 136
LEU A 133
 None
 0.88A 1j8uA-3ge6A:
undetectable		 1j8uA-3ge6A:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hf8 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 LEU A 242
PHE A 241
LEU A 236
ALA A 119
 None
 0.87A 1j8uA-3hf8A:
42.3		 1j8uA-3hf8A:
64.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hf8 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		5 VAL A 232
LEU A 236
PHE A 241
LEU A 242
ALA A 309
 None
 0.30A 1j8uA-3hf8A:
42.3		 1j8uA-3hf8A:
64.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjz TRANSALDOLASE B

(Prochlorococcus
marinus) 		PF00923
(TAL_FSA) 		4 LEU A  38
SER A  37
LEU A  40
ALA A 309
 None
NA  A 340 ( 4.7A)
None
NA  A 340 (-3.4A)
 0.78A 1j8uA-3hjzA:
undetectable		 1j8uA-3hjzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq9 CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 VAL A 294
PHE A 214
LEU A 215
ALA A  29
 HEM  A 401 ( 3.9A)
None
None
None
 0.76A 1j8uA-3hq9A:
undetectable		 1j8uA-3hq9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 VAL A 163
LEU A 153
LEU A  73
ALA A  78
 None
None
EDO  A 627 (-4.4A)
None
 0.64A 1j8uA-3mosA:
undetectable		 1j8uA-3mosA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pry HEAT SHOCK PROTEIN
HSP 90-BETA

(Homo sapiens) 		PF00183
(HSP90) 		4 LEU A 419
SER A 417
PHE A 416
LEU A 454
 None
 0.89A 1j8uA-3pryA:
undetectable		 1j8uA-3pryA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw3 AMINOPEPTIDASE C

(Parabacteroides
distasonis) 		PF03051
(Peptidase_C1_2) 		4 SER A  61
PHE A  64
LEU A  65
ALA A 114
 None
 0.77A 1j8uA-3pw3A:
undetectable		 1j8uA-3pw3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE

(Entamoeba
histolytica) 		PF00145
(DNA_methylase) 		4 VAL A 238
LEU A 209
SER A 207
LEU A 211
 None
 0.83A 1j8uA-3qv2A:
undetectable		 1j8uA-3qv2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 LEU A 112
PHE A 117
LEU A 118
ALA A 501
 None
 0.55A 1j8uA-3s29A:
undetectable		 1j8uA-3s29A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zta ANTI-SIGMA-FACTOR
ANTAGONIST (STAS)
DOMAIN PROTEIN

(Moorella
thermoacetica) 		no annotation 4 VAL A  66
LEU A 122
SER A 120
PHE A 121
 None
 0.77A 1j8uA-3ztaA:
undetectable		 1j8uA-3ztaA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k CULLIN-4A

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU A 126
SER A 128
PHE A 131
LEU A 132
 None
 0.83A 1j8uA-4a0kA:
undetectable		 1j8uA-4a0kA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a64 CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin) 		4 LEU A 262
SER A 264
PHE A 267
LEU A 268
 None
 0.61A 1j8uA-4a64A:
undetectable		 1j8uA-4a64A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 VAL A 294
PHE A 214
LEU A 215
ALA A  29
 HEC  A 424 ( 4.1A)
HEC  A 424 ( 4.9A)
None
None
 0.78A 1j8uA-4aalA:
undetectable		 1j8uA-4aalA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 LEU A 445
LEU A 448
LEU A 245
ALA A 137
 None
 0.81A 1j8uA-4av6A:
undetectable		 1j8uA-4av6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF12341
(Mcl1_mid) 		4 LEU A 885
PHE A 870
LEU A 867
ALA A 894
 None
 0.72A 1j8uA-4c95A:
undetectable		 1j8uA-4c95A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 SER A 391
PHE A 394
LEU A 395
ALA A 437
 None
 0.64A 1j8uA-4hjhA:
undetectable		 1j8uA-4hjhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imm OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Moraxella
catarrhalis) 		PF13360
(PQQ_2) 		4 VAL A 184
SER A 160
LEU A 158
ALA A 204
 None
 0.84A 1j8uA-4immA:
undetectable		 1j8uA-4immA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itm TETRAACYLDISACCHARID
E 4'-KINASE

(Aquifex
aeolicus) 		PF02606
(LpxK) 		4 LEU A  12
SER A  10
PHE A   9
ALA A 167
 None
 0.72A 1j8uA-4itmA:
undetectable		 1j8uA-4itmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 LEU A 344
SER A 346
LEU A 349
ALA A 363
 None
 0.87A 1j8uA-4k0eA:
undetectable		 1j8uA-4k0eA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 LEU B 348
LEU B 351
PHE B 318
ALA B 315
 None
 0.73A 1j8uA-4ov6B:
undetectable		 1j8uA-4ov6B:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		4 VAL A 382
LEU A 314
SER A 312
LEU A 321
 None
 0.83A 1j8uA-4p53A:
undetectable		 1j8uA-4p53A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE

(Roseobacter
denitrificans) 		PF03480
(DctP) 		4 VAL A 224
SER A 218
LEU A 215
ALA A  37
 None
None
CS2  A 401 (-4.2A)
None
 0.88A 1j8uA-4pc9A:
undetectable		 1j8uA-4pc9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4png LD04004P

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 VAL A 152
LEU A 142
LEU A 171
ALA A 111
 None
 0.81A 1j8uA-4pngA:
undetectable		 1j8uA-4pngA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px9 ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A 150
SER A 290
PHE A 289
LEU A 239
 None
 0.82A 1j8uA-4px9A:
undetectable		 1j8uA-4px9A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 VAL A2608
LEU A2741
LEU A2740
ALA A2896
 GOL  A3201 (-4.1A)
None
None
None
 0.85A 1j8uA-4qyrA:
undetectable		 1j8uA-4qyrA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Weissella
paramesenteroides) 		PF13377
(Peripla_BP_3) 		4 VAL A 108
LEU A  98
LEU A 123
ALA A  75
 None
 0.76A 1j8uA-4rk6A:
undetectable		 1j8uA-4rk6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF12109
(CXCR4_N) 		4 LEU A  91
SER A  46
PHE A  49
LEU A  50
 None
 0.72A 1j8uA-4rwsA:
undetectable		 1j8uA-4rwsA:
20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		5 VAL A 278
LEU A 282
PHE A 287
LEU A 288
ALA A 355
 None
None
IMD  A 600 ( 4.4A)
None
None
 0.25A 1j8uA-4v06A:
48.0		 1j8uA-4v06A:
61.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		4 LEU A 676
LEU A 597
LEU A 715
ALA A 726
 None
 0.89A 1j8uA-4w8yA:
undetectable		 1j8uA-4w8yA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xga OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF07244
(POTRA) 		4 VAL B 258
LEU B 226
SER B 228
LEU B 231
 None
 0.83A 1j8uA-4xgaB:
undetectable		 1j8uA-4xgaB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		4 VAL A 161
LEU A 179
LEU A 199
ALA A 234
 None
 0.83A 1j8uA-4xiaA:
undetectable		 1j8uA-4xiaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2

(Mus musculus) 		PF06046
(Sec6) 		4 VAL A 432
LEU A 361
LEU A 356
ALA A 331
 None
 0.88A 1j8uA-5b86A:
undetectable		 1j8uA-5b86A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw6 DRBRCC36

(Danio rerio) 		PF01398
(JAB) 		4 LEU A   8
SER A  10
PHE A  13
LEU A  14
 None
 0.71A 1j8uA-5cw6A:
undetectable		 1j8uA-5cw6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn8 GTPASE DER

(Coxiella
burnetii) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 VAL A 334
LEU A 191
SER A 189
ALA A 237
 None
None
GDP  A 501 (-4.5A)
None
 0.86A 1j8uA-5dn8A:
undetectable		 1j8uA-5dn8A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 150
SER A 290
PHE A 289
LEU A 239
 None
 0.79A 1j8uA-5e7jA:
undetectable		 1j8uA-5e7jA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftp ANAPHASE-PROMOTING
COMPLEX SUBUNIT 8

(Schizosaccharomyces
pombe) 		PF04049
(ANAPC8) 		5 VAL A 161
LEU A 123
SER A 125
LEU A 121
ALA A 106
 None
 1.37A 1j8uA-5ftpA:
undetectable		 1j8uA-5ftpA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU C 143
SER C 306
LEU C 336
ALA C 319
 None
None
ACT  C1740 ( 4.5A)
None
 0.88A 1j8uA-5g5gC:
undetectable		 1j8uA-5g5gC:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		4 LEU A  48
SER A  35
PHE A  36
ALA A 362
 None
 0.59A 1j8uA-5gmxA:
undetectable		 1j8uA-5gmxA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 LEU A 489
SER A 487
LEU A 484
ALA A 637
 None
 0.77A 1j8uA-5gwjA:
undetectable		 1j8uA-5gwjA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL

(Homo sapiens) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 LEU A 537
LEU A 536
SER A 549
LEU A 500
 None
 0.85A 1j8uA-5hphA:
undetectable		 1j8uA-5hphA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		4 VAL A 178
SER A  93
PHE A  94
ALA A  96
 None
 0.83A 1j8uA-5j7zA:
undetectable		 1j8uA-5j7zA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		4 VAL A  74
SER A 145
LEU A 123
ALA A 138
 None
 0.71A 1j8uA-5j84A:
undetectable		 1j8uA-5j84A:
19.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE

(Dictyostelium
discoideum) 		PF00351
(Biopterin_H) 		5 VAL A 233
LEU A 236
LEU A 237
PHE A 242
LEU A 243
 None
 0.61A 1j8uA-5jk6A:
48.0		 1j8uA-5jk6A:
47.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkq PFVFT1

(Plasmodium
falciparum) 		no annotation 4 LEU A 262
SER A 260
LEU A 257
ALA A 226
 None
 0.89A 1j8uA-5jkqA:
undetectable		 1j8uA-5jkqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		4 VAL A 222
LEU A 388
LEU A 241
ALA A 292
 None
 0.84A 1j8uA-5jy9A:
undetectable		 1j8uA-5jy9A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 VAL B1982
LEU B1978
SER B1955
LEU B1975
 None
 0.88A 1j8uA-5k8dB:
undetectable		 1j8uA-5k8dB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 VAL A 213
LEU A  33
PHE A  34
LEU A   6
 None
 0.84A 1j8uA-5kjmA:
undetectable		 1j8uA-5kjmA:
23.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l01 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		5 VAL A 232
LEU A 236
PHE A 241
LEU A 242
ALA A 309
 None
None
6Z4  A 502 ( 4.8A)
None
6Z4  A 502 (-3.6A)
 0.27A 1j8uA-5l01A:
43.4		 1j8uA-5l01A:
53.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 VAL g  69
LEU M  33
LEU M  32
LEU M  77
 None
 0.84A 1j8uA-5lc5g:
undetectable		 1j8uA-5lc5g:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcn UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF12146
(Hydrolase_4) 		4 VAL A  25
LEU A 205
SER A 207
ALA A 182
 None
 0.86A 1j8uA-5lcnA:
undetectable		 1j8uA-5lcnA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT

(Ovis aries) 		PF00420
(Oxidored_q2) 		4 VAL k 155
SER k 103
LEU k 106
ALA k  59
 None
 0.80A 1j8uA-5lnkk:
undetectable		 1j8uA-5lnkk:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 341
SER A 339
LEU A 343
ALA A 297
 None
 0.86A 1j8uA-5mdnA:
undetectable		 1j8uA-5mdnA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 VAL A 444
LEU A 463
LEU A 464
PHE A 490
ALA A 467
 None
 1.23A 1j8uA-5mscA:
undetectable		 1j8uA-5mscA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu4 TAIL TUBULAR PROTEIN
A

(Klebsiella
virus KP32) 		PF17212
(Tube) 		4 LEU A  47
SER A 139
PHE A 142
ALA A  23
 None
 0.71A 1j8uA-5mu4A:
undetectable		 1j8uA-5mu4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf2 MINOR FIMBRIUM
SUBUNIT MFA1

(Porphyromonas
gingivalis) 		no annotation 4 VAL A 481
LEU A 366
LEU A 365
ALA A 323
 None
 0.77A 1j8uA-5nf2A:
undetectable		 1j8uA-5nf2A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 VAL A 808
LEU A 763
LEU A 740
ALA A 782
 None
 0.88A 1j8uA-5o1pA:
undetectable		 1j8uA-5o1pA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 LEU A 348
LEU A 351
PHE A 318
ALA A 315
 None
 0.66A 1j8uA-5vlhA:
undetectable		 1j8uA-5vlhA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 VAL A 590
SER A 916
PHE A 917
ALA A 922
 None
 0.76A 1j8uA-5w21A:
undetectable		 1j8uA-5w21A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 4 LEU A 586
LEU A 590
LEU A 595
ALA A 637
 None
 0.85A 1j8uA-5wblA:
undetectable		 1j8uA-5wblA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 4 VAL A 418
LEU A 436
LEU A 435
ALA A 431
 None
 0.88A 1j8uA-5xgvA:
undetectable		 1j8uA-5xgvA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS02G0668100 PROTEIN
OS07G0580900 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		4 VAL C  38
LEU C  80
LEU C 121
ALA A 153
 None
 0.81A 1j8uA-5xn6C:
undetectable		 1j8uA-5xn6C:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Homo sapiens) 		no annotation 4 VAL A 114
LEU A 151
LEU A 153
ALA A 179
 None
 0.82A 1j8uA-5yx9A:
undetectable		 1j8uA-5yx9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 4 LEU A 649
SER A 467
PHE A 470
LEU A 471
 None
 0.68A 1j8uA-6etiA:
undetectable		 1j8uA-6etiA:
12.38