SIMILAR PATTERNS OF AMINO ACIDS FOR 1J7K_A_ACTA701
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3b | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermotogamaritima) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | GLY A 189LEU A 227GLY A 191ARG A 190 | None | 1.28A | 1j7kA-1b3bA:2.1 | 1j7kA-1b3bA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e8t | HEMAGGLUTININ-NEURAMINIDASE (Avianavulavirus 1) |
PF00423(HN) | 4 | GLY A 246LEU A 245GLY A 276ARG A 274 | None | 1.43A | 1j7kA-1e8tA:0.0 | 1j7kA-1e8tA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fgg | GLUCURONYLTRANSFERASE I (Homo sapiens) |
PF03360(Glyco_transf_43) | 4 | GLY A 328LEU A 322GLY A 326ARG A 327 | None | 1.31A | 1j7kA-1fggA:2.0 | 1j7kA-1fggA:22.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1in8 | HOLLIDAY JUNCTIONDNA HELICASE RUVB (Thermotogamaritima) |
PF05491(RuvB_C)PF05496(RuvB_N) | 4 | GLY A 278LEU A 279GLY A 313ARG A 314 | None | 0.11A | 1j7kA-1in8A:43.5 | 1j7kA-1in8A:99.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itu | RENAL DIPEPTIDASE (Homo sapiens) |
PF01244(Peptidase_M19) | 4 | GLY A 358LEU A 357GLY A 359ARG A 362 | None | 1.18A | 1j7kA-1ituA:1.0 | 1j7kA-1ituA:23.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ixr | RUVB (Thermusthermophilus) |
PF05491(RuvB_C)PF05496(RuvB_N) | 4 | GLY C 266LEU C 267GLY C 301ARG C 302 | None | 0.61A | 1j7kA-1ixrC:12.7 | 1j7kA-1ixrC:53.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k0k | PROFILIN (Saccharomycescerevisiae) |
PF00235(Profilin) | 4 | GLY A 79LEU A 70GLY A 85ARG A 80 | None | 1.06A | 1j7kA-1k0kA:0.0 | 1j7kA-1k0kA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m5y | SURVIVAL PROTEINSURA (Escherichiacoli) |
PF00639(Rotamase)PF09312(SurA_N)PF13616(Rotamase_3) | 4 | GLY A 264LEU A 183GLY A 262ARG A 260 | None | 1.46A | 1j7kA-1m5yA:0.0 | 1j7kA-1m5yA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r3d | CONSERVEDHYPOTHETICAL PROTEINVC1974 (Vibrio cholerae) |
PF12697(Abhydrolase_6) | 4 | GLY A 94LEU A 92GLY A 119ARG A 95 | None | 1.13A | 1j7kA-1r3dA:0.0 | 1j7kA-1r3dA:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6a | GENOME POLYPROTEIN (Dengue virus) |
PF01728(FtsJ) | 4 | GLY A 120LEU A 123GLY A 93ARG A 263 | None | 1.29A | 1j7kA-1r6aA:undetectable | 1j7kA-1r6aA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdj | BIOSYNTHETICTHREONINE DEAMINASE (Escherichiacoli) |
PF00291(PALP)PF00585(Thr_dehydrat_C) | 4 | GLY A 167LEU A 169GLY A 165ARG A 64 | None | 1.45A | 1j7kA-1tdjA:undetectable | 1j7kA-1tdjA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLY A 136LEU A 140GLY A 204ARG A 207 | None | 1.31A | 1j7kA-1v8bA:undetectable | 1j7kA-1v8bA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wuu | GALACTOKINASE (Homo sapiens) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C)PF10509(GalKase_gal_bdg) | 4 | GLY A 71LEU A 72GLY A 124ARG A 68 | None | 1.27A | 1j7kA-1wuuA:undetectable | 1j7kA-1wuuA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xdk | RETINOIC ACIDRECEPTOR, BETA (Mus musculus) |
PF00104(Hormone_recep) | 4 | GLY B 294LEU B 391GLY B 296ARG B 387 | 9CR B 600 (-4.7A)NoneNoneNone | 1.27A | 1j7kA-1xdkB:undetectable | 1j7kA-1xdkB:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xrs | D-LYSINE5,6-AMINOMUTASEALPHA SUBUNIT (Acetoanaerobiumsticklandii) |
PF09043(Lys-AminoMut_A) | 4 | GLY A 494LEU A 240GLY A 497ARG A 274 | None | 1.37A | 1j7kA-1xrsA:2.8 | 1j7kA-1xrsA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y4u | CHAPERONE PROTEINHTPG (Escherichiacoli) |
PF00183(HSP90)PF02518(HATPase_c) | 4 | GLY A 82LEU A 46GLY A 173ARG A 172 | None | 1.47A | 1j7kA-1y4uA:undetectable | 1j7kA-1y4uA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2arz | HYPOTHETICAL PROTEINPA4388 (Pseudomonasaeruginosa) |
PF10615(DUF2470)PF13883(Pyrid_oxidase_2) | 4 | GLY A 207LEU A 208GLY A 205ARG A 203 | None | 1.45A | 1j7kA-2arzA:undetectable | 1j7kA-2arzA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3b | GLUCOSE-BINDINGPROTEIN (Thermusthermophilus) |
PF01547(SBP_bac_1) | 4 | GLY A 390LEU A 392GLY A 388ARG A 391 | None | 1.10A | 1j7kA-2b3bA:undetectable | 1j7kA-2b3bA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bug | SERINE/THREONINEPROTEIN PHOSPHATASE5 (Homo sapiens) |
PF00515(TPR_1)PF13181(TPR_8) | 4 | GLY A 66LEU A 70GLY A 98ARG A 101 | None | 1.09A | 1j7kA-2bugA:undetectable | 1j7kA-2bugA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e5v | L-ASPARTATE OXIDASE (Sulfurisphaeratokodaii) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | GLY A 345LEU A 68GLY A 342ARG A 465 | None | 1.25A | 1j7kA-2e5vA:undetectable | 1j7kA-2e5vA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fji | EXOCYST COMPLEXCOMPONENT SEC6 (Saccharomycescerevisiae) |
PF06046(Sec6) | 4 | GLY 1 540LEU 1 541GLY 1 539ARG 1 448 | None | 1.13A | 1j7kA-2fji1:undetectable | 1j7kA-2fji1:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h0a | TRANSCRIPTIONALREGULATOR (Thermusthermophilus) |
PF13377(Peripla_BP_3) | 4 | GLY A 166LEU A 164GLY A 204ARG A 167 | None | 0.68A | 1j7kA-2h0aA:2.6 | 1j7kA-2h0aA:25.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ior | CHAPERONE PROTEINHTPG (Escherichiacoli) |
PF02518(HATPase_c) | 4 | GLY A 82LEU A 46GLY A 173ARG A 172 | None | 1.42A | 1j7kA-2iorA:undetectable | 1j7kA-2iorA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pnw | MEMBRANE-BOUND LYTICMUREINTRANSGLYCOSYLASE (Agrobacteriumfabrum) |
PF03562(MltA)PF06725(3D) | 4 | GLY A 169LEU A 170GLY A 167ARG A 168 | None | 1.42A | 1j7kA-2pnwA:undetectable | 1j7kA-2pnwA:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0q | ARYL ESTERASE (Mycolicibacteriumsmegmatis) |
PF13472(Lipase_GDSL_2) | 4 | GLY A 52LEU A 53GLY A 9ARG A 56 | None | 1.44A | 1j7kA-2q0qA:undetectable | 1j7kA-2q0qA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ql3 | PROBABLETRANSCRIPTIONALREGULATOR, LYSRFAMILY PROTEIN (Rhodococcusjostii) |
PF03466(LysR_substrate) | 4 | GLY A 242LEU A 263GLY A 244ARG A 243 | None | 1.27A | 1j7kA-2ql3A:undetectable | 1j7kA-2ql3A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rb7 | PEPTIDASE,M20/M25/M40 FAMILY (Desulfovibrioalaskensis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | GLY A 94LEU A 82GLY A 96ARG A 95 | None | 1.37A | 1j7kA-2rb7A:undetectable | 1j7kA-2rb7A:24.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v24 | SPRYDOMAIN-CONTAININGSOCS BOX PROTEIN 4 (Homo sapiens) |
PF00622(SPRY) | 4 | GLY A 145LEU A 144GLY A 110ARG A 109 | None | 1.44A | 1j7kA-2v24A:undetectable | 1j7kA-2v24A:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y5t | C1C1 (Mus musculus;Mus musculus) |
no annotationPF01391(Collagen) | 4 | GLY E 19LEU E 20GLY F 19ARG F 18 | None | 1.20A | 1j7kA-2y5tE:undetectable | 1j7kA-2y5tE:7.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ycd | GLUTATHIONES-TRANSFERASE (Agrobacteriumtumefaciens) |
PF02798(GST_N)PF13410(GST_C_2) | 4 | GLY A 31LEU A 32GLY A 29ARG A 30 | NoneGTB A 501 (-4.0A)NoneGTB A 501 ( 4.9A) | 1.12A | 1j7kA-2ycdA:undetectable | 1j7kA-2ycdA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zcx | TETR-FAMILYTRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N) | 4 | GLY A 36LEU A 35GLY A 40ARG A 39 | None | 1.38A | 1j7kA-2zcxA:undetectable | 1j7kA-2zcxA:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a05 | TRYPTOPHANYL-TRNASYNTHETASE (Aeropyrumpernix) |
PF00579(tRNA-synt_1b) | 4 | GLY A 297LEU A 296GLY A 298ARG A 287 | NoneNoneSF4 A 373 ( 4.3A)None | 0.92A | 1j7kA-3a05A:undetectable | 1j7kA-3a05A:26.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a0h | PHOTOSYSTEM II D2PROTEIN (Thermosynechococcusvulcanus) |
PF00124(Photo_RC) | 4 | GLY D 34LEU D 37GLY D 31ARG D 128 | None | 1.33A | 1j7kA-3a0hD:undetectable | 1j7kA-3a0hD:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3act | CELLOBIOSEPHOSPHORYLASE (Cellulomonasgilvus) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | GLY A 42LEU A 37GLY A 69ARG A 70 | None | 1.28A | 1j7kA-3actA:undetectable | 1j7kA-3actA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dci | ARYLESTERASE (Agrobacteriumfabrum) |
PF13472(Lipase_GDSL_2) | 4 | GLY A 47LEU A 48GLY A 8ARG A 51 | None | 1.44A | 1j7kA-3dciA:undetectable | 1j7kA-3dciA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f9t | L-TYROSINEDECARBOXYLASE MFNA (Methanocaldococcusjannaschii) |
PF00282(Pyridoxal_deC) | 4 | GLY A 58LEU A 57GLY A 284ARG A 286 | None | 1.11A | 1j7kA-3f9tA:undetectable | 1j7kA-3f9tA:24.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fij | LIN1909 PROTEIN (Listeriainnocua) |
PF07722(Peptidase_C26) | 4 | GLY A 117LEU A 120GLY A 69ARG A 116 | None | 1.09A | 1j7kA-3fijA:undetectable | 1j7kA-3fijA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLY A 141LEU A 145GLY A 203ARG A 206 | None | 1.32A | 1j7kA-3glqA:undetectable | 1j7kA-3glqA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gqm | CELL INHIBITINGFACTOR (CIFBP) (Burkholderiapseudomallei) |
PF16374(CIF) | 4 | GLY A 141LEU A 239GLY A 237ARG A 142 | None | 1.23A | 1j7kA-3gqmA:undetectable | 1j7kA-3gqmA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gv0 | TRANSCRIPTIONALREGULATOR, LACIFAMILY (Agrobacteriumfabrum) |
PF13377(Peripla_BP_3) | 4 | GLY A 305LEU A 303GLY A 89ARG A 306 | None | 0.77A | 1j7kA-3gv0A:undetectable | 1j7kA-3gv0A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gzy | BIPHENYL DIOXYGENASESUBUNIT ALPHABIPHENYL DIOXYGENASESUBUNIT BETA (Comamonastestosteroni;Comamonastestosteroni) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A)PF00866(Ring_hydroxyl_B) | 4 | GLY A 246LEU A 247GLY B 89ARG B 92 | None | 1.28A | 1j7kA-3gzyA:undetectable | 1j7kA-3gzyA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kq5 | HYPOTHETICALCYTOSOLIC PROTEIN (Coxiellaburnetii) |
PF07515(TraI_2_C) | 4 | GLY A 117LEU A 120GLY A 87ARG A 90 | None | 1.28A | 1j7kA-3kq5A:undetectable | 1j7kA-3kq5A:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kq5 | HYPOTHETICALCYTOSOLIC PROTEIN (Coxiellaburnetii) |
PF07515(TraI_2_C) | 4 | GLY A 117LEU A 120GLY A 91ARG A 90 | None | 1.11A | 1j7kA-3kq5A:undetectable | 1j7kA-3kq5A:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mlt | HIV-1 GP120 THIRDVARIABLE REGION (V3)CROWN (Humanimmunodeficiencyvirus 1) |
no annotation | 4 | GLY P 312LEU P 309GLY P 314ARG P 315 | None | 1.45A | 1j7kA-3mltP:undetectable | 1j7kA-3mltP:7.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8c | NCK-ASSOCIATEDPROTEIN 1 (Homo sapiens) |
PF09735(Nckap1) | 4 | GLY B 26LEU B 583GLY B 24ARG B 23 | None | 1.47A | 1j7kA-3p8cB:undetectable | 1j7kA-3p8cB:14.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pfi | HOLLIDAY JUNCTIONATP-DEPENDENT DNAHELICASE RUVB (Campylobacterjejuni) |
PF05491(RuvB_C)PF05496(RuvB_N) | 4 | GLY A 278LEU A 279GLY A 313ARG A 314 | None | 0.70A | 1j7kA-3pfiA:12.6 | 1j7kA-3pfiA:46.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4d | LACTOSEPHOSPHORYLASE (Cellulomonasuda) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | GLY A 42LEU A 37GLY A 43ARG A 70 | None | 1.27A | 1j7kA-3s4dA:undetectable | 1j7kA-3s4dA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4d | LACTOSEPHOSPHORYLASE (Cellulomonasuda) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | GLY A 42LEU A 37GLY A 69ARG A 70 | None | 1.22A | 1j7kA-3s4dA:undetectable | 1j7kA-3s4dA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3suc | PRENECK APPENDAGEPROTEIN (Bacillus virusphi29) |
PF11962(Peptidase_G2)PF12708(Pectate_lyase_3) | 4 | GLY A 248LEU A 249GLY A 247ARG A 222 | None | 1.49A | 1j7kA-3sucA:undetectable | 1j7kA-3sucA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ua4 | PROTEIN ARGININEN-METHYLTRANSFERASE5 (Caenorhabditiselegans) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 4 | GLY A 401LEU A 400GLY A 404ARG A 405 | None | 0.85A | 1j7kA-3ua4A:2.6 | 1j7kA-3ua4A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vkg | DYNEIN HEAVY CHAIN,CYTOPLASMIC (Dictyosteliumdiscoideum) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 4 | GLY A1992LEU A1991GLY A1937ARG A1993 | None | 0.96A | 1j7kA-3vkgA:undetectable | 1j7kA-3vkgA:7.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x1b | LACCASE (Lentinus) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | GLY A 196LEU A 206GLY A 204ARG A 197 | None | 0.99A | 1j7kA-3x1bA:undetectable | 1j7kA-3x1bA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3g | DNA-BINDING PROTEINSMUBP-2 (Homo sapiens) |
PF13086(AAA_11)PF13087(AAA_12) | 4 | GLY A 58LEU A 59GLY A 61ARG A 62 | None | 1.06A | 1j7kA-4b3gA:2.5 | 1j7kA-4b3gA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhq | COMPETENCE PROTEINPILN (Thermusthermophilus) |
no annotation | 4 | GLY A 189LEU A 190GLY A 187ARG A 188 | None | 1.15A | 1j7kA-4bhqA:undetectable | 1j7kA-4bhqA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c9b | PRE-MRNA-SPLICINGFACTOR CWC22 HOMOLOG (Homo sapiens) |
PF02854(MIF4G) | 4 | GLY B 195LEU B 382GLY B 193ARG B 194 | None | 1.00A | 1j7kA-4c9bB:undetectable | 1j7kA-4c9bB:26.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cr2 | 26S PROTEASEREGULATORY SUBUNIT 4HOMOLOG (Saccharomycescerevisiae) |
PF00004(AAA) | 4 | GLY I 258LEU I 257GLY I 260ARG I 304 | None | 1.00A | 1j7kA-4cr2I:14.1 | 1j7kA-4cr2I:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzt | AQUALYSIN-1 (Thermusaquaticus) |
PF00082(Peptidase_S8) | 4 | GLY A 62LEU A 60GLY A 64ARG A 95 | None | 1.49A | 1j7kA-4dztA:undetectable | 1j7kA-4dztA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4em6 | GLUCOSE-6-PHOSPHATEISOMERASE (Brucellamelitensis) |
no annotation | 4 | GLY D 316LEU D 315GLY D 319ARG D 491 | None | 1.33A | 1j7kA-4em6D:undetectable | 1j7kA-4em6D:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzh | HEMAGGLUTININ-NEURAMINIDASE (Avianavulavirus 1) |
PF00423(HN) | 4 | GLY A 246LEU A 245GLY A 276ARG A 274 | None | 1.43A | 1j7kA-4fzhA:undetectable | 1j7kA-4fzhA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iqe | CARBOXYVINYL-CARBOXYPHOSPHONATEPHOSPHORYLMUTASE (Bacillusanthracis) |
PF13714(PEP_mutase) | 4 | GLY A 170LEU A 171GLY A 167ARG A 166 | None | 1.24A | 1j7kA-4iqeA:undetectable | 1j7kA-4iqeA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iuk | NREA PROTEIN (Staphylococcuscarnosus) |
PF13185(GAF_2) | 4 | GLY A 69LEU A 70GLY A 64ARG A 73 | None | 1.04A | 1j7kA-4iukA:undetectable | 1j7kA-4iukA:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j6f | PUTATIVE ALCOHOLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | GLY A 21LEU A 22GLY A 20ARG A 58 | None | 1.25A | 1j7kA-4j6fA:undetectable | 1j7kA-4j6fA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kbf | HEAT RESISTANT RNADEPENDENT ATPASE (Thermusthermophilus) |
PF00270(DEAD)PF00271(Helicase_C) | 4 | GLY A 20LEU A 21GLY A 18ARG A 19 | NoneAMP A 401 (-4.6A)NoneNone | 1.38A | 1j7kA-4kbfA:6.8 | 1j7kA-4kbfA:26.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmo | TELOMERASE REVERSETRANSCRIPTASE (Takifugurubripes) |
PF12009(Telomerase_RBD) | 4 | GLY A 302LEU A 301GLY A 306ARG A 308 | None | 1.07A | 1j7kA-4lmoA:undetectable | 1j7kA-4lmoA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmo | TELOMERASE REVERSETRANSCRIPTASE (Takifugurubripes) |
PF12009(Telomerase_RBD) | 4 | GLY A 302LEU A 301GLY A 307ARG A 308 | None | 0.85A | 1j7kA-4lmoA:undetectable | 1j7kA-4lmoA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ls9 | DHH FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF01368(DHH)PF02272(DHHA1) | 4 | GLY A 247LEU A 243GLY A 245ARG A 246 | None | 1.36A | 1j7kA-4ls9A:undetectable | 1j7kA-4ls9A:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4myd | 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATESYNTHASE (Escherichiacoli) |
PF12697(Abhydrolase_6) | 4 | GLY A 89LEU A 87GLY A 111ARG A 90 | None164 A 301 (-4.0A)None164 A 301 (-3.6A) | 1.15A | 1j7kA-4mydA:undetectable | 1j7kA-4mydA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nav | HYPOTHETICAL PROTEINXCC279 (Xanthomonascampestris) |
no annotation | 4 | GLY D 53LEU D 51GLY D 55ARG D 160 | None | 1.21A | 1j7kA-4navD:undetectable | 1j7kA-4navD:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7h | GLUTATHIONES-TRANSFERASE (Rhodospirillumrubrum) |
PF13410(GST_C_2)PF13417(GST_N_3) | 4 | GLY A 82LEU A 81GLY A 83ARG A 88 | None | 1.41A | 1j7kA-4o7hA:undetectable | 1j7kA-4o7hA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ogc | HNH ENDONUCLEASEDOMAIN PROTEIN (Actinomycesnaeslundii) |
PF01844(HNH) | 4 | GLY A 841LEU A 871GLY A 839ARG A 877 | None | 1.12A | 1j7kA-4ogcA:2.3 | 1j7kA-4ogcA:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqj | PKS (Streptomycesalbus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | GLY A 503LEU A 502GLY A 119ARG A 688 | None | 0.99A | 1j7kA-4oqjA:undetectable | 1j7kA-4oqjA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qtu | PUTATIVEMETHYLTRANSFERASEBUD23 (Saccharomycescerevisiae) |
PF08241(Methyltransf_11) | 4 | GLY B 59LEU B 60GLY B 86ARG B 89 | NoneSAM B 301 (-4.0A)NoneNone | 1.32A | 1j7kA-4qtuB:2.5 | 1j7kA-4qtuB:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s13 | FERULIC ACIDDECARBOXYLASE 1 (Saccharomycescerevisiae) |
PF01977(UbiD) | 4 | GLY A 186LEU A 187GLY A 176ARG A 175 | None | 1.27A | 1j7kA-4s13A:undetectable | 1j7kA-4s13A:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tx1 | ESTERASE (Sinorhizobiummeliloti) |
PF13472(Lipase_GDSL_2) | 4 | GLY A 47LEU A 48GLY A 8ARG A 51 | None | 1.44A | 1j7kA-4tx1A:undetectable | 1j7kA-4tx1A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xly | UNCHARACTERIZEDPROTEIN BLR2150 (Bradyrhizobiumdiazoefficiens) |
no annotation | 4 | GLY A 96LEU A 95GLY A 98ARG A 113 | None | 1.44A | 1j7kA-4xlyA:2.7 | 1j7kA-4xlyA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z2a | FURIN (Homo sapiens) |
PF00082(Peptidase_S8)PF01483(P_proprotein) | 4 | GLY A 283LEU A 285GLY A 281ARG A 282 | None | 1.20A | 1j7kA-4z2aA:undetectable | 1j7kA-4z2aA:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zad | FDC1 (Candidadubliniensis) |
PF01977(UbiD) | 4 | GLY A 190LEU A 191GLY A 180ARG A 179 | None4LU A 603 (-4.1A)NoneNone | 1.25A | 1j7kA-4zadA:undetectable | 1j7kA-4zadA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgc | KELCH PROTEIN (Plasmodiumfalciparum) |
PF01344(Kelch_1)PF02214(BTB_2)PF13418(Kelch_4) | 4 | GLY A 639LEU A 647GLY A 625ARG A 622 | None | 0.98A | 1j7kA-4zgcA:undetectable | 1j7kA-4zgcA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d4k | POLYMERICIMMUNOGLOBULINRECEPTOR (Homo sapiens) |
PF07686(V-set) | 4 | GLY A 233LEU A 231GLY A 296ARG A 232 | None | 1.21A | 1j7kA-5d4kA:undetectable | 1j7kA-5d4kA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7q | ACYL-COA SYNTHETASE (Streptomycesplatensis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | GLY A 152LEU A 153GLY A 151ARG A 41 | None | 1.05A | 1j7kA-5e7qA:3.0 | 1j7kA-5e7qA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exk | LIPOYL SYNTHASE (Mycobacteriumtuberculosis) |
PF04055(Radical_SAM)PF16881(LIAS_N) | 4 | GLY A 221LEU A 220GLY A 223ARG A 261 | None | 1.38A | 1j7kA-5exkA:undetectable | 1j7kA-5exkA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hoe | HYDROLASE (Sinorhizobiummeliloti) |
PF13472(Lipase_GDSL_2) | 4 | GLY A 54LEU A 55GLY A 11ARG A 58 | None | 1.46A | 1j7kA-5hoeA:undetectable | 1j7kA-5hoeA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikm | NS5 METHYLTRANSFERASE (Dengue virus) |
PF01728(FtsJ) | 4 | GLY A 120LEU A 123GLY A 93ARG A 262 | NoneNoneNoneSO4 A 309 (-3.9A) | 1.29A | 1j7kA-5ikmA:undetectable | 1j7kA-5ikmA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j84 | DIHYDROXY-ACIDDEHYDRATASE (Rhizobiumleguminosarum) |
PF00920(ILVD_EDD) | 4 | GLY A 241LEU A 239GLY A 73ARG A 242 | None | 1.05A | 1j7kA-5j84A:2.3 | 1j7kA-5j84A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lv9 | THERMOPHILICTRYPTOPHANHALOGENASE (Streptomycesviolaceusniger) |
PF04820(Trp_halogenase) | 4 | GLY A 234LEU A 235GLY A 231ARG A 233 | None | 0.98A | 1j7kA-5lv9A:undetectable | 1j7kA-5lv9A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 4 | GLY A1924LEU A1923GLY A1869ARG A1925 | None | 0.76A | 1j7kA-5nugA:undetectable | 1j7kA-5nugA:5.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ols | RHAMNOGALACTURONANLYASE (Bacteroidesthetaiotaomicron) |
no annotation | 4 | GLY A 281LEU A 318GLY A 269ARG A 317 | NoneGTR A 608 (-4.6A)NoneNone | 1.02A | 1j7kA-5olsA:undetectable | 1j7kA-5olsA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ols | RHAMNOGALACTURONANLYASE (Bacteroidesthetaiotaomicron) |
no annotation | 4 | GLY A 281LEU A 318GLY A 279ARG A 317 | NoneGTR A 608 (-4.6A)NoneNone | 1.03A | 1j7kA-5olsA:undetectable | 1j7kA-5olsA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ulu | CADHERIN-23 (Mus musculus) |
no annotation | 4 | GLY A2105LEU A2094GLY A2062ARG A2103 | None | 1.40A | 1j7kA-5uluA:undetectable | 1j7kA-5uluA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6q | ALDEHYDE OXIDASELARGE SUBUNIT (Methylobacillussp. KY4400) |
no annotation | 4 | GLY C 491LEU C 671GLY C 489ARG C 40 | MCN C 802 (-3.6A)MCN C 802 (-3.9A)MCN C 802 (-3.3A)None | 1.18A | 1j7kA-5y6qC:undetectable | 1j7kA-5y6qC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yd0 | SCHLAFEN 8 (Rattusnorvegicus) |
no annotation | 4 | GLY A 75LEU A 78GLY A 26ARG A 30 | None | 0.99A | 1j7kA-5yd0A:undetectable | 1j7kA-5yd0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yfp | EXOCYST COMPLEXCOMPONENT SEC6 (Saccharomycescerevisiae) |
no annotation | 4 | GLY C 540LEU C 541GLY C 539ARG C 448 | None | 1.36A | 1j7kA-5yfpC:undetectable | 1j7kA-5yfpC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z59 | PROTEIN-TYROSINEPHOSPHATASE (Thermococcuskodakarensis) |
no annotation | 4 | GLY A 98LEU A 97GLY A 101ARG A 127 | None | 1.05A | 1j7kA-5z59A:undetectable | 1j7kA-5z59A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zrt | - (-) |
no annotation | 4 | GLY A 59LEU A 54GLY A 57ARG A 58 | None | 1.08A | 1j7kA-5zrtA:undetectable | 1j7kA-5zrtA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b7k | ENDO-ALPHA-(1->5)-L-ARABINANASE (Bacilluslicheniformis) |
no annotation | 4 | GLY A 29LEU A 30GLY A 27ARG A 35 | None | 1.26A | 1j7kA-6b7kA:undetectable | 1j7kA-6b7kA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c2j | RNAP1RNAP2 (Escherichiavirus N4;Escherichiavirus N4) |
no annotationno annotation | 4 | GLY B 249LEU B 250GLY A 239ARG B 253 | None | 1.18A | 1j7kA-6c2jB:undetectable | 1j7kA-6c2jB:undetectable |