SIMILAR PATTERNS OF AMINO ACIDS FOR 1J7K_A_ACTA701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A 189
LEU A 227
GLY A 191
ARG A 190
 None
 1.28A 1j7kA-1b3bA:
2.1		 1j7kA-1b3bA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 GLY A 246
LEU A 245
GLY A 276
ARG A 274
 None
 1.43A 1j7kA-1e8tA:
0.0		 1j7kA-1e8tA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fgg GLUCURONYLTRANSFERAS
E I

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 GLY A 328
LEU A 322
GLY A 326
ARG A 327
 None
 1.31A 1j7kA-1fggA:
2.0		 1j7kA-1fggA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1in8 HOLLIDAY JUNCTION
DNA HELICASE RUVB

(Thermotoga
maritima) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		4 GLY A 278
LEU A 279
GLY A 313
ARG A 314
 None
 0.11A 1j7kA-1in8A:
43.5		 1j7kA-1in8A:
99.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		4 GLY A 358
LEU A 357
GLY A 359
ARG A 362
 None
 1.18A 1j7kA-1ituA:
1.0		 1j7kA-1ituA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ixr RUVB

(Thermus
thermophilus) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		4 GLY C 266
LEU C 267
GLY C 301
ARG C 302
 None
 0.61A 1j7kA-1ixrC:
12.7		 1j7kA-1ixrC:
53.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0k PROFILIN

(Saccharomyces
cerevisiae) 		PF00235
(Profilin) 		4 GLY A  79
LEU A  70
GLY A  85
ARG A  80
 None
 1.06A 1j7kA-1k0kA:
0.0		 1j7kA-1k0kA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5y SURVIVAL PROTEIN
SURA

(Escherichia
coli) 		PF00639
(Rotamase)
PF09312
(SurA_N)
PF13616
(Rotamase_3) 		4 GLY A 264
LEU A 183
GLY A 262
ARG A 260
 None
 1.46A 1j7kA-1m5yA:
0.0		 1j7kA-1m5yA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3d CONSERVED
HYPOTHETICAL PROTEIN
VC1974

(Vibrio cholerae) 		PF12697
(Abhydrolase_6) 		4 GLY A  94
LEU A  92
GLY A 119
ARG A  95
 None
 1.13A 1j7kA-1r3dA:
0.0		 1j7kA-1r3dA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 GLY A 120
LEU A 123
GLY A  93
ARG A 263
 None
 1.29A 1j7kA-1r6aA:
undetectable		 1j7kA-1r6aA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		4 GLY A 167
LEU A 169
GLY A 165
ARG A  64
 None
 1.45A 1j7kA-1tdjA:
undetectable		 1j7kA-1tdjA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLY A 136
LEU A 140
GLY A 204
ARG A 207
 None
 1.31A 1j7kA-1v8bA:
undetectable		 1j7kA-1v8bA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 GLY A  71
LEU A  72
GLY A 124
ARG A  68
 None
 1.27A 1j7kA-1wuuA:
undetectable		 1j7kA-1wuuA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		4 GLY B 294
LEU B 391
GLY B 296
ARG B 387
 9CR  B 600 (-4.7A)
None
None
None
 1.27A 1j7kA-1xdkB:
undetectable		 1j7kA-1xdkB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 GLY A 494
LEU A 240
GLY A 497
ARG A 274
 None
 1.37A 1j7kA-1xrsA:
2.8		 1j7kA-1xrsA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 GLY A  82
LEU A  46
GLY A 173
ARG A 172
 None
 1.47A 1j7kA-1y4uA:
undetectable		 1j7kA-1y4uA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arz HYPOTHETICAL PROTEIN
PA4388

(Pseudomonas
aeruginosa) 		PF10615
(DUF2470)
PF13883
(Pyrid_oxidase_2) 		4 GLY A 207
LEU A 208
GLY A 205
ARG A 203
 None
 1.45A 1j7kA-2arzA:
undetectable		 1j7kA-2arzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		4 GLY A 390
LEU A 392
GLY A 388
ARG A 391
 None
 1.10A 1j7kA-2b3bA:
undetectable		 1j7kA-2b3bA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bug SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00515
(TPR_1)
PF13181
(TPR_8) 		4 GLY A  66
LEU A  70
GLY A  98
ARG A 101
 None
 1.09A 1j7kA-2bugA:
undetectable		 1j7kA-2bugA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 345
LEU A  68
GLY A 342
ARG A 465
 None
 1.25A 1j7kA-2e5vA:
undetectable		 1j7kA-2e5vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fji EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		PF06046
(Sec6) 		4 GLY 1 540
LEU 1 541
GLY 1 539
ARG 1 448
 None
 1.13A 1j7kA-2fji1:
undetectable		 1j7kA-2fji1:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		4 GLY A 166
LEU A 164
GLY A 204
ARG A 167
 None
 0.68A 1j7kA-2h0aA:
2.6		 1j7kA-2h0aA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ior CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF02518
(HATPase_c) 		4 GLY A  82
LEU A  46
GLY A 173
ARG A 172
 None
 1.42A 1j7kA-2iorA:
undetectable		 1j7kA-2iorA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE

(Agrobacterium
fabrum) 		PF03562
(MltA)
PF06725
(3D) 		4 GLY A 169
LEU A 170
GLY A 167
ARG A 168
 None
 1.42A 1j7kA-2pnwA:
undetectable		 1j7kA-2pnwA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0q ARYL ESTERASE

(Mycolicibacterium
smegmatis) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  52
LEU A  53
GLY A   9
ARG A  56
 None
 1.44A 1j7kA-2q0qA:
undetectable		 1j7kA-2q0qA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF03466
(LysR_substrate) 		4 GLY A 242
LEU A 263
GLY A 244
ARG A 243
 None
 1.27A 1j7kA-2ql3A:
undetectable		 1j7kA-2ql3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb7 PEPTIDASE,
M20/M25/M40 FAMILY

(Desulfovibrio
alaskensis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLY A  94
LEU A  82
GLY A  96
ARG A  95
 None
 1.37A 1j7kA-2rb7A:
undetectable		 1j7kA-2rb7A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4

(Homo sapiens) 		PF00622
(SPRY) 		4 GLY A 145
LEU A 144
GLY A 110
ARG A 109
 None
 1.44A 1j7kA-2v24A:
undetectable		 1j7kA-2v24A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5t C1
C1

(Mus musculus;
Mus musculus) 		no annotation
PF01391
(Collagen) 		4 GLY E  19
LEU E  20
GLY F  19
ARG F  18
 None
 1.20A 1j7kA-2y5tE:
undetectable		 1j7kA-2y5tE:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycd GLUTATHIONE
S-TRANSFERASE

(Agrobacterium
tumefaciens) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 GLY A  31
LEU A  32
GLY A  29
ARG A  30
 None
GTB  A 501 (-4.0A)
None
GTB  A 501 ( 4.9A)
 1.12A 1j7kA-2ycdA:
undetectable		 1j7kA-2ycdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcx TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 GLY A  36
LEU A  35
GLY A  40
ARG A  39
 None
 1.38A 1j7kA-2zcxA:
undetectable		 1j7kA-2zcxA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		4 GLY A 297
LEU A 296
GLY A 298
ARG A 287
 None
None
SF4  A 373 ( 4.3A)
None
 0.92A 1j7kA-3a05A:
undetectable		 1j7kA-3a05A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II D2
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00124
(Photo_RC) 		4 GLY D  34
LEU D  37
GLY D  31
ARG D 128
 None
 1.33A 1j7kA-3a0hD:
undetectable		 1j7kA-3a0hD:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A  42
LEU A  37
GLY A  69
ARG A  70
 None
 1.28A 1j7kA-3actA:
undetectable		 1j7kA-3actA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dci ARYLESTERASE

(Agrobacterium
fabrum) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  47
LEU A  48
GLY A   8
ARG A  51
 None
 1.44A 1j7kA-3dciA:
undetectable		 1j7kA-3dciA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		4 GLY A  58
LEU A  57
GLY A 284
ARG A 286
 None
 1.11A 1j7kA-3f9tA:
undetectable		 1j7kA-3f9tA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fij LIN1909 PROTEIN

(Listeria
innocua) 		PF07722
(Peptidase_C26) 		4 GLY A 117
LEU A 120
GLY A  69
ARG A 116
 None
 1.09A 1j7kA-3fijA:
undetectable		 1j7kA-3fijA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLY A 141
LEU A 145
GLY A 203
ARG A 206
 None
 1.32A 1j7kA-3glqA:
undetectable		 1j7kA-3glqA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqm CELL INHIBITING
FACTOR (CIFBP)

(Burkholderia
pseudomallei) 		PF16374
(CIF) 		4 GLY A 141
LEU A 239
GLY A 237
ARG A 142
 None
 1.23A 1j7kA-3gqmA:
undetectable		 1j7kA-3gqmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv0 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Agrobacterium
fabrum) 		PF13377
(Peripla_BP_3) 		4 GLY A 305
LEU A 303
GLY A  89
ARG A 306
 None
 0.77A 1j7kA-3gv0A:
undetectable		 1j7kA-3gv0A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni;
Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		4 GLY A 246
LEU A 247
GLY B  89
ARG B  92
 None
 1.28A 1j7kA-3gzyA:
undetectable		 1j7kA-3gzyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Coxiella
burnetii) 		PF07515
(TraI_2_C) 		4 GLY A 117
LEU A 120
GLY A  87
ARG A  90
 None
 1.28A 1j7kA-3kq5A:
undetectable		 1j7kA-3kq5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Coxiella
burnetii) 		PF07515
(TraI_2_C) 		4 GLY A 117
LEU A 120
GLY A  91
ARG A  90
 None
 1.11A 1j7kA-3kq5A:
undetectable		 1j7kA-3kq5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlt HIV-1 GP120 THIRD
VARIABLE REGION (V3)
CROWN

(Human
immunodeficiency
virus 1) 		no annotation 4 GLY P 312
LEU P 309
GLY P 314
ARG P 315
 None
 1.45A 1j7kA-3mltP:
undetectable		 1j7kA-3mltP:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 GLY B  26
LEU B 583
GLY B  24
ARG B  23
 None
 1.47A 1j7kA-3p8cB:
undetectable		 1j7kA-3p8cB:
14.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Campylobacter
jejuni) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		4 GLY A 278
LEU A 279
GLY A 313
ARG A 314
 None
 0.70A 1j7kA-3pfiA:
12.6		 1j7kA-3pfiA:
46.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE

(Cellulomonas
uda) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A  42
LEU A  37
GLY A  43
ARG A  70
 None
 1.27A 1j7kA-3s4dA:
undetectable		 1j7kA-3s4dA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE

(Cellulomonas
uda) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A  42
LEU A  37
GLY A  69
ARG A  70
 None
 1.22A 1j7kA-3s4dA:
undetectable		 1j7kA-3s4dA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 GLY A 248
LEU A 249
GLY A 247
ARG A 222
 None
 1.49A 1j7kA-3sucA:
undetectable		 1j7kA-3sucA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 GLY A 401
LEU A 400
GLY A 404
ARG A 405
 None
 0.85A 1j7kA-3ua4A:
2.6		 1j7kA-3ua4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLY A1992
LEU A1991
GLY A1937
ARG A1993
 None
 0.96A 1j7kA-3vkgA:
undetectable		 1j7kA-3vkgA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 196
LEU A 206
GLY A 204
ARG A 197
 None
 0.99A 1j7kA-3x1bA:
undetectable		 1j7kA-3x1bA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3g DNA-BINDING PROTEIN
SMUBP-2

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 GLY A  58
LEU A  59
GLY A  61
ARG A  62
 None
 1.06A 1j7kA-4b3gA:
2.5		 1j7kA-4b3gA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhq COMPETENCE PROTEIN
PILN

(Thermus
thermophilus) 		no annotation 4 GLY A 189
LEU A 190
GLY A 187
ARG A 188
 None
 1.15A 1j7kA-4bhqA:
undetectable		 1j7kA-4bhqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG

(Homo sapiens) 		PF02854
(MIF4G) 		4 GLY B 195
LEU B 382
GLY B 193
ARG B 194
 None
 1.00A 1j7kA-4c9bB:
undetectable		 1j7kA-4c9bB:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 GLY I 258
LEU I 257
GLY I 260
ARG I 304
 None
 1.00A 1j7kA-4cr2I:
14.1		 1j7kA-4cr2I:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus) 		PF00082
(Peptidase_S8) 		4 GLY A  62
LEU A  60
GLY A  64
ARG A  95
 None
 1.49A 1j7kA-4dztA:
undetectable		 1j7kA-4dztA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 4 GLY D 316
LEU D 315
GLY D 319
ARG D 491
 None
 1.33A 1j7kA-4em6D:
undetectable		 1j7kA-4em6D:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzh HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 GLY A 246
LEU A 245
GLY A 276
ARG A 274
 None
 1.43A 1j7kA-4fzhA:
undetectable		 1j7kA-4fzhA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqe CARBOXYVINYL-CARBOXY
PHOSPHONATE
PHOSPHORYLMUTASE

(Bacillus
anthracis) 		PF13714
(PEP_mutase) 		4 GLY A 170
LEU A 171
GLY A 167
ARG A 166
 None
 1.24A 1j7kA-4iqeA:
undetectable		 1j7kA-4iqeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuk NREA PROTEIN

(Staphylococcus
carnosus) 		PF13185
(GAF_2) 		4 GLY A  69
LEU A  70
GLY A  64
ARG A  73
 None
 1.04A 1j7kA-4iukA:
undetectable		 1j7kA-4iukA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  21
LEU A  22
GLY A  20
ARG A  58
 None
 1.25A 1j7kA-4j6fA:
undetectable		 1j7kA-4j6fA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A  20
LEU A  21
GLY A  18
ARG A  19
 None
AMP  A 401 (-4.6A)
None
None
 1.38A 1j7kA-4kbfA:
6.8		 1j7kA-4kbfA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmo TELOMERASE REVERSE
TRANSCRIPTASE

(Takifugu
rubripes) 		PF12009
(Telomerase_RBD) 		4 GLY A 302
LEU A 301
GLY A 306
ARG A 308
 None
 1.07A 1j7kA-4lmoA:
undetectable		 1j7kA-4lmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmo TELOMERASE REVERSE
TRANSCRIPTASE

(Takifugu
rubripes) 		PF12009
(Telomerase_RBD) 		4 GLY A 302
LEU A 301
GLY A 307
ARG A 308
 None
 0.85A 1j7kA-4lmoA:
undetectable		 1j7kA-4lmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls9 DHH FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 GLY A 247
LEU A 243
GLY A 245
ARG A 246
 None
 1.36A 1j7kA-4ls9A:
undetectable		 1j7kA-4ls9A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 GLY A  89
LEU A  87
GLY A 111
ARG A  90
 None
164  A 301 (-4.0A)
None
164  A 301 (-3.6A)
 1.15A 1j7kA-4mydA:
undetectable		 1j7kA-4mydA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nav HYPOTHETICAL PROTEIN
XCC279

(Xanthomonas
campestris) 		no annotation 4 GLY D  53
LEU D  51
GLY D  55
ARG D 160
 None
 1.21A 1j7kA-4navD:
undetectable		 1j7kA-4navD:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7h GLUTATHIONE
S-TRANSFERASE

(Rhodospirillum
rubrum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 GLY A  82
LEU A  81
GLY A  83
ARG A  88
 None
 1.41A 1j7kA-4o7hA:
undetectable		 1j7kA-4o7hA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		4 GLY A 841
LEU A 871
GLY A 839
ARG A 877
 None
 1.12A 1j7kA-4ogcA:
2.3		 1j7kA-4ogcA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A 503
LEU A 502
GLY A 119
ARG A 688
 None
 0.99A 1j7kA-4oqjA:
undetectable		 1j7kA-4oqjA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		4 GLY B  59
LEU B  60
GLY B  86
ARG B  89
 None
SAM  B 301 (-4.0A)
None
None
 1.32A 1j7kA-4qtuB:
2.5		 1j7kA-4qtuB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		4 GLY A 186
LEU A 187
GLY A 176
ARG A 175
 None
 1.27A 1j7kA-4s13A:
undetectable		 1j7kA-4s13A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx1 ESTERASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  47
LEU A  48
GLY A   8
ARG A  51
 None
 1.44A 1j7kA-4tx1A:
undetectable		 1j7kA-4tx1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xly UNCHARACTERIZED
PROTEIN BLR2150

(Bradyrhizobium
diazoefficiens) 		no annotation 4 GLY A  96
LEU A  95
GLY A  98
ARG A 113
 None
 1.44A 1j7kA-4xlyA:
2.7		 1j7kA-4xlyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 GLY A 283
LEU A 285
GLY A 281
ARG A 282
 None
 1.20A 1j7kA-4z2aA:
undetectable		 1j7kA-4z2aA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		4 GLY A 190
LEU A 191
GLY A 180
ARG A 179
 None
4LU  A 603 (-4.1A)
None
None
 1.25A 1j7kA-4zadA:
undetectable		 1j7kA-4zadA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgc KELCH PROTEIN

(Plasmodium
falciparum) 		PF01344
(Kelch_1)
PF02214
(BTB_2)
PF13418
(Kelch_4) 		4 GLY A 639
LEU A 647
GLY A 625
ARG A 622
 None
 0.98A 1j7kA-4zgcA:
undetectable		 1j7kA-4zgcA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		4 GLY A 233
LEU A 231
GLY A 296
ARG A 232
 None
 1.21A 1j7kA-5d4kA:
undetectable		 1j7kA-5d4kA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 152
LEU A 153
GLY A 151
ARG A  41
 None
 1.05A 1j7kA-5e7qA:
3.0		 1j7kA-5e7qA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exk LIPOYL SYNTHASE

(Mycobacterium
tuberculosis) 		PF04055
(Radical_SAM)
PF16881
(LIAS_N) 		4 GLY A 221
LEU A 220
GLY A 223
ARG A 261
 None
 1.38A 1j7kA-5exkA:
undetectable		 1j7kA-5exkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hoe HYDROLASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  54
LEU A  55
GLY A  11
ARG A  58
 None
 1.46A 1j7kA-5hoeA:
undetectable		 1j7kA-5hoeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		4 GLY A 120
LEU A 123
GLY A  93
ARG A 262
 None
None
None
SO4  A 309 (-3.9A)
 1.29A 1j7kA-5ikmA:
undetectable		 1j7kA-5ikmA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		4 GLY A 241
LEU A 239
GLY A  73
ARG A 242
 None
 1.05A 1j7kA-5j84A:
2.3		 1j7kA-5j84A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		4 GLY A 234
LEU A 235
GLY A 231
ARG A 233
 None
 0.98A 1j7kA-5lv9A:
undetectable		 1j7kA-5lv9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLY A1924
LEU A1923
GLY A1869
ARG A1925
 None
 0.76A 1j7kA-5nugA:
undetectable		 1j7kA-5nugA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 281
LEU A 318
GLY A 269
ARG A 317
 None
GTR  A 608 (-4.6A)
None
None
 1.02A 1j7kA-5olsA:
undetectable		 1j7kA-5olsA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 281
LEU A 318
GLY A 279
ARG A 317
 None
GTR  A 608 (-4.6A)
None
None
 1.03A 1j7kA-5olsA:
undetectable		 1j7kA-5olsA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulu CADHERIN-23

(Mus musculus) 		no annotation 4 GLY A2105
LEU A2094
GLY A2062
ARG A2103
 None
 1.40A 1j7kA-5uluA:
undetectable		 1j7kA-5uluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 GLY C 491
LEU C 671
GLY C 489
ARG C  40
 MCN  C 802 (-3.6A)
MCN  C 802 (-3.9A)
MCN  C 802 (-3.3A)
None
 1.18A 1j7kA-5y6qC:
undetectable		 1j7kA-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yd0 SCHLAFEN 8

(Rattus
norvegicus) 		no annotation 4 GLY A  75
LEU A  78
GLY A  26
ARG A  30
 None
 0.99A 1j7kA-5yd0A:
undetectable		 1j7kA-5yd0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		no annotation 4 GLY C 540
LEU C 541
GLY C 539
ARG C 448
 None
 1.36A 1j7kA-5yfpC:
undetectable		 1j7kA-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z59 PROTEIN-TYROSINE
PHOSPHATASE

(Thermococcus
kodakarensis) 		no annotation 4 GLY A  98
LEU A  97
GLY A 101
ARG A 127
 None
 1.05A 1j7kA-5z59A:
undetectable		 1j7kA-5z59A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zrt -

(-) 		no annotation 4 GLY A  59
LEU A  54
GLY A  57
ARG A  58
 None
 1.08A 1j7kA-5zrtA:
undetectable		 1j7kA-5zrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE

(Bacillus
licheniformis) 		no annotation 4 GLY A  29
LEU A  30
GLY A  27
ARG A  35
 None
 1.26A 1j7kA-6b7kA:
undetectable		 1j7kA-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP1
RNAP2

(Escherichia
virus N4;
Escherichia
virus N4) 		no annotation
no annotation 		4 GLY B 249
LEU B 250
GLY A 239
ARG B 253
 None
 1.18A 1j7kA-6c2jB:
undetectable		 1j7kA-6c2jB:
undetectable