SIMILAR PATTERNS OF AMINO ACIDS FOR 1J36_B_LPRB802_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		4 ARG A 251
ALA A 121
SER A 117
TYR A  67
 None
 1.31A 1j36B-1qfxA:
0.5		 1j36B-1qfxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en8 UNCHARACTERIZED
NTF-2 LIKE PROTEIN

(Paraburkholderia
xenovorans) 		PF12680
(SnoaL_2) 		4 ARG A  54
ALA A  18
SER A  17
TYR A  80
 None
 1.16A 1j36B-3en8A:
undetectable		 1j36B-3en8A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucx SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 ARG A 224
ALA A 218
SER A 220
TYR A 213
 None
None
None
1PE  A 262 ( 3.9A)
 1.11A 1j36B-3ucxA:
0.5		 1j36B-3ucxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN

(Chaetomium
thermophilum) 		PF04840
(Vps16_C) 		4 ARG B 596
ALA B 623
SER B 624
TYR B 613
 None
 1.45A 1j36B-4kmoB:
0.9		 1j36B-4kmoB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w68 SINGLE DOMAIN
ANTIBODY

(Lama glama) 		no annotation 4 ARG B  31
ALA B  24
SER B  25
TYR B 118
 None
 1.47A 1j36B-4w68B:
undetectable		 1j36B-4w68B:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ARG A 337
ALA A 285
SER A 284
TYR A 255
 None
None
TLA  A 602 ( 4.8A)
None
 1.42A 1j36B-5kyvA:
0.0		 1j36B-5kyvA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 ARG A 812
ALA A  55
SER A  83
TYR A 687
 None
 1.32A 1j36B-5lq3A:
0.0		 1j36B-5lq3A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 ARG B 311
ALA B 606
SER B 603
TYR B 616
 GOL  B 704 (-3.0A)
None
None
None
 1.49A 1j36B-5swiB:
0.0		 1j36B-5swiB:
20.43