SIMILAR PATTERNS OF AMINO ACIDS FOR 1IWI_A_CAMA418_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 231
VAL A 216
ASP A 214
VAL A 197
 None
 0.98A 1iwiA-1bxzA:
undetectable		 1iwiA-1bxzA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 LEU A 623
VAL A 626
VAL A 661
VAL A 638
 None
 0.93A 1iwiA-1c30A:
0.0		 1iwiA-1c30A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)

(Thermotoga
maritima) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 124
VAL A 127
VAL A 251
VAL A 336
 None
 0.87A 1iwiA-1c3cA:
0.0		 1iwiA-1c3cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cdo ALCOHOL
DEHYDROGENASE

(Gadus morhua) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 259
VAL A 242
ASP A 240
VAL A 223
 None
 0.98A 1iwiA-1cdoA:
undetectable		 1iwiA-1cdoA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		4 PHE A 549
TYR A 533
VAL A 487
VAL A 489
 None
 0.91A 1iwiA-1fwxA:
0.0		 1iwiA-1fwxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		4 THR A  39
VAL A  62
VAL A 213
VAL A  50
 None
 0.92A 1iwiA-1g8pA:
0.0		 1iwiA-1g8pA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 THR A 247
LEU A 424
VAL A 427
VAL A 443
 None
MPD  A 802 ( 4.4A)
None
None
 0.92A 1iwiA-1kwgA:
0.0		 1iwiA-1kwgA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575

(Aquifex
aeolicus) 		PF01709
(Transcrip_reg) 		4 PHE A 117
LEU A 222
VAL A 234
VAL A 130
 None
 0.92A 1iwiA-1lfpA:
undetectable		 1iwiA-1lfpA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlf REGULATORY PROTEIN
REPA

(Escherichia
coli) 		PF13481
(AAA_25) 		4 LEU A 212
VAL A 138
ASP A 140
VAL A 175
 None
 0.94A 1iwiA-1nlfA:
0.0		 1iwiA-1nlfA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 VAL B 231
VAL B 211
ASP B 209
VAL B 273
 None
 0.71A 1iwiA-1nvmB:
undetectable		 1iwiA-1nvmB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 PHE X 493
LEU X 456
VAL X 560
VAL X 600
 None
 0.79A 1iwiA-1r6bX:
undetectable		 1iwiA-1r6bX:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		4 PHE A 171
VAL A 190
VAL A 137
VAL A 159
 None
 0.90A 1iwiA-1ru4A:
undetectable		 1iwiA-1ru4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6t PUTATIVE PROTEIN

(Aquifex
aeolicus) 		PF01751
(Toprim) 		4 PHE 1  69
VAL 1  54
VAL 1  93
VAL 1  65
 None
 0.81A 1iwiA-1t6t1:
undetectable		 1iwiA-1t6t1:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 LEU A 335
VAL A 336
VAL A 352
VAL A 354
 None
 0.96A 1iwiA-1v43A:
undetectable		 1iwiA-1v43A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 THR A 421
LEU A 325
VAL A 328
VAL A  64
 None
 0.93A 1iwiA-1v5cA:
undetectable		 1iwiA-1v5cA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9j BOLA-LIKE PROTEIN
RIKEN CDNA
1110025L05

(Mus musculus) 		PF01722
(BolA) 		4 LEU A  87
VAL A  83
VAL A  48
VAL A  66
 None
 0.63A 1iwiA-1v9jA:
undetectable		 1iwiA-1v9jA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vav ALGINATE LYASE
PA1167

(Pseudomonas
aeruginosa) 		PF08787
(Alginate_lyase2) 		4 LEU A 169
VAL A 164
VAL A 134
VAL A 117
 None
 0.98A 1iwiA-1vavA:
undetectable		 1iwiA-1vavA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		5 PHE A 236
THR A 263
LEU A 303
VAL A 307
VAL A 244
 None
 1.38A 1iwiA-1vbmA:
undetectable		 1iwiA-1vbmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 PHE A 616
THR A 620
LEU A 657
VAL A 584
 None
 0.98A 1iwiA-1x9nA:
undetectable		 1iwiA-1x9nA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 PHE A 137
TYR A 141
VAL A 116
VAL A 306
 None
 0.94A 1iwiA-1ykwA:
undetectable		 1iwiA-1ykwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoc HYPOTHETICAL PROTEIN
PA1835

(Pseudomonas
aeruginosa) 		PF14539
(DUF4442) 		4 LEU A  53
VAL A  52
VAL A 128
VAL A 103
 None
 0.95A 1iwiA-1yocA:
undetectable		 1iwiA-1yocA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxb PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE

(Streptomyces
coelicolor) 		PF01503
(PRA-PH) 		4 PHE A   6
LEU A  90
VAL A  86
VAL A  72
 None
 0.96A 1iwiA-1yxbA:
undetectable		 1iwiA-1yxbA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		4 TYR A  93
LEU A 150
VAL A 138
VAL A  81
 SAZ  A 709 (-4.9A)
None
None
None
 0.89A 1iwiA-1yyrA:
undetectable		 1iwiA-1yyrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z47 PUTATIVE
ABC-TRANSPORTER
ATP-BINDING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 LEU A 168
VAL A  89
VAL A  72
VAL A  79
 None
 0.98A 1iwiA-1z47A:
undetectable		 1iwiA-1z47A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuo HYPOTHETICAL PROTEIN
LOC92912

(Homo sapiens) 		PF00179
(UQ_con) 		4 PHE A 274
VAL A 322
VAL A 229
VAL A 241
 None
 0.75A 1iwiA-1zuoA:
undetectable		 1iwiA-1zuoA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.93A 1iwiA-2awaA:
undetectable		 1iwiA-2awaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awg 38 KDA FK-506
BINDING PROTEIN

(Homo sapiens) 		PF00254
(FKBP_C) 		4 LEU A 200
VAL A 198
VAL A 152
ASP A 157
 None
 0.88A 1iwiA-2awgA:
undetectable		 1iwiA-2awgA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		4 PHE A  43
THR A  32
VAL A  62
VAL A  93
 HEM  A 200 (-3.5A)
None
HEM  A 200 ( 3.8A)
HEM  A 200 (-4.3A)
 0.95A 1iwiA-2b7hA:
undetectable		 1iwiA-2b7hA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqz 177AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13023
(HD_3) 		4 LEU A  11
VAL A   8
VAL A  94
VAL A  98
 None
 0.89A 1iwiA-2cqzA:
undetectable		 1iwiA-2cqzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6l LECTIN, GALACTOSE
BINDING, SOLUBLE 9

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		4 PHE X  92
VAL X  46
VAL X 119
VAL X 111
 None
 0.95A 1iwiA-2d6lX:
undetectable		 1iwiA-2d6lX:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 THR A 442
VAL A 104
ASP A 125
VAL A 123
 None
 0.88A 1iwiA-2dkhA:
undetectable		 1iwiA-2dkhA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 LEU A 442
VAL A 408
VAL A 312
VAL A 280
 None
 0.93A 1iwiA-2exrA:
undetectable		 1iwiA-2exrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 THR A 176
LEU A 216
VAL A 213
ASP A 270
 MG  A 602 ( 3.3A)
None
None
MG  A 602 ( 4.8A)
 0.92A 1iwiA-2f43A:
undetectable		 1iwiA-2f43A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 PHE A 221
THR A 165
LEU A  35
VAL A 387
 None
 0.91A 1iwiA-2h4tA:
undetectable		 1iwiA-2h4tA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		4 TYR A 138
LEU A 383
VAL A 159
VAL A 133
 None
None
None
FAD  A 501 (-3.9A)
 0.90A 1iwiA-2i0zA:
undetectable		 1iwiA-2i0zA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		4 PHE A 254
LEU A 194
VAL A 226
ASP A 198
 None
 0.95A 1iwiA-2i62A:
undetectable		 1iwiA-2i62A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		4 LEU A 123
VAL A 114
VAL A  94
VAL A  93
 None
 0.96A 1iwiA-2k8dA:
undetectable		 1iwiA-2k8dA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		4 PHE A  90
LEU A 123
VAL A 114
VAL A  94
 None
 0.98A 1iwiA-2k8dA:
undetectable		 1iwiA-2k8dA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knb E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Rattus
norvegicus) 		PF00240
(ubiquitin) 		4 THR A  21
VAL A  29
VAL A  67
VAL A   5
 None
 0.86A 1iwiA-2knbA:
undetectable		 1iwiA-2knbA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA

(Homo sapiens) 		PF00076
(RRM_1) 		4 THR B 129
LEU B 184
VAL B 147
VAL B 164
 None
 0.89A 1iwiA-2kxnB:
undetectable		 1iwiA-2kxnB:
17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		8 PHE A  87
TYR A  96
THR A 101
LEU A 244
VAL A 247
VAL A 295
ASP A 297
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
 0.29A 1iwiA-2m56A:
67.5		 1iwiA-2m56A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m83 PROTEIN PHOSPHATASE
1 REGULATORY SUBUNIT
3A

(Oryctolagus
cuniculus) 		PF03370
(CBM_21) 		4 THR A 135
LEU A 231
VAL A 207
VAL A 161
 None
 0.96A 1iwiA-2m83A:
undetectable		 1iwiA-2m83A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8

(Homo sapiens) 		PF00254
(FKBP_C) 		4 LEU A 144
VAL A 142
VAL A  95
ASP A 100
 None
 0.95A 1iwiA-2mf9A:
undetectable		 1iwiA-2mf9A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocx NODULATION
FUCOSYLTRANSFERASE
NODZ

(Bradyrhizobium
sp. WM9) 		PF05830
(NodZ) 		4 LEU A 198
VAL A 201
VAL A 239
VAL A 219
 None
 0.90A 1iwiA-2ocxA:
undetectable		 1iwiA-2ocxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
putida) 		PF00106
(adh_short) 		4 LEU A 112
VAL A 115
VAL A 165
VAL A 166
 None
 0.74A 1iwiA-2q2vA:
undetectable		 1iwiA-2q2vA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		4 VAL A 205
VAL A 109
ASP A 111
VAL A  71
 None
 0.90A 1iwiA-2q8nA:
undetectable		 1iwiA-2q8nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgx UBIQUITIN-CONJUGATIN
G ENZYME E2 Q1

(Homo sapiens) 		PF00179
(UQ_con) 		4 PHE A  74
VAL A 122
VAL A  29
VAL A  41
 None
 0.53A 1iwiA-2qgxA:
undetectable		 1iwiA-2qgxA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 PHE A 137
TYR A 141
VAL A 116
VAL A 306
 None
 0.97A 1iwiA-2qygA:
undetectable		 1iwiA-2qygA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 TYR A 444
LEU A 568
VAL A 392
VAL A 363
 None
 0.95A 1iwiA-2qzpA:
undetectable		 1iwiA-2qzpA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 THR A 204
LEU A   8
VAL A 121
ASP A 147
 None
 0.98A 1iwiA-2r8rA:
undetectable		 1iwiA-2r8rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 269
VAL A 293
VAL A  93
VAL A 134
 None
 0.99A 1iwiA-2v6bA:
undetectable		 1iwiA-2v6bA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		4 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.98A 1iwiA-2wsmA:
undetectable		 1iwiA-2wsmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0i MALATE DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 THR A 271
LEU A 293
VAL A 261
VAL A  95
 None
 0.90A 1iwiA-2x0iA:
undetectable		 1iwiA-2x0iA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 LEU A  23
VAL A  26
VAL A  38
VAL A 209
 None
 0.95A 1iwiA-2yz2A:
undetectable		 1iwiA-2yz2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A 205
VAL A 208
VAL A 218
VAL A 232
 None
 0.82A 1iwiA-3aizA:
undetectable		 1iwiA-3aizA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 THR A 276
LEU A 267
VAL A 263
VAL A 113
 None
 0.95A 1iwiA-3b5qA:
undetectable		 1iwiA-3b5qA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 TYR A 227
LEU A 279
VAL A 278
VAL A 223
 None
 0.97A 1iwiA-3b9tA:
undetectable		 1iwiA-3b9tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOB

(Methylosinus
trichosporium) 		PF04744
(Monooxygenase_B) 		4 THR A 361
LEU A 359
VAL A 317
VAL A 295
 None
 0.98A 1iwiA-3chxA:
undetectable		 1iwiA-3chxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		4 LEU A 433
VAL A 431
VAL A 498
VAL A 487
 None
 0.90A 1iwiA-3d3aA:
undetectable		 1iwiA-3d3aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwz BETA-LACTAMASE

(Mycobacterium
tuberculosis) 		PF13354
(Beta-lactamase2) 		4 PHE A  48
VAL A 305
VAL A 275
VAL A  63
 None
 0.70A 1iwiA-3dwzA:
undetectable		 1iwiA-3dwzA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE

(Lactobacillus
delbrueckii) 		PF00155
(Aminotran_1_2) 		4 LEU A 290
VAL A 293
ASP A  37
VAL A 374
 None
 0.93A 1iwiA-3dzzA:
undetectable		 1iwiA-3dzzA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejk DTDP SUGAR ISOMERASE

(Desulfovibrio
alaskensis) 		PF00908
(dTDP_sugar_isom) 		4 LEU A  88
VAL A 104
VAL A 135
VAL A  79
 None
 0.94A 1iwiA-3ejkA:
undetectable		 1iwiA-3ejkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		4 LEU A 123
VAL A 121
VAL A  96
VAL A  89
 None
 0.98A 1iwiA-3emyA:
undetectable		 1iwiA-3emyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 THR A1170
LEU A1206
VAL A1209
VAL A1190
 None
 0.81A 1iwiA-3f2bA:
undetectable		 1iwiA-3f2bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3geh TRNA MODIFICATION
GTPASE MNME

(Nostoc sp. PCC
7120) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 LEU A 237
VAL A 266
ASP A 245
VAL A 271
 None
 0.97A 1iwiA-3gehA:
undetectable		 1iwiA-3gehA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxv REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB) 		4 PHE A  40
LEU A  53
ASP A  39
VAL A  98
 None
 0.70A 1iwiA-3gxvA:
undetectable		 1iwiA-3gxvA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 THR A1490
LEU A1486
VAL A1771
VAL A1881
 None
 0.92A 1iwiA-3hmjA:
undetectable		 1iwiA-3hmjA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Nitrosospira
multiformis) 		PF00365
(PFK) 		4 LEU A 286
VAL A 282
VAL A 214
VAL A 243
 None
 0.80A 1iwiA-3hnoA:
undetectable		 1iwiA-3hnoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		4 LEU A  38
VAL A  41
VAL A  70
VAL A  49
 None
 0.78A 1iwiA-3hnrA:
undetectable		 1iwiA-3hnrA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 VAL A 464
VAL A 259
ASP A 251
VAL A 253
 None
 0.89A 1iwiA-3ialA:
undetectable		 1iwiA-3ialA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib6 UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF13419
(HAD_2) 		4 THR A  12
LEU A 140
VAL A   5
VAL A 117
 None
 0.67A 1iwiA-3ib6A:
undetectable		 1iwiA-3ib6A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxv 70 KDA
PEPTIDYL-PROLYL
ISOMERASE

(Triticum
aestivum) 		PF00254
(FKBP_C) 		4 LEU A 380
VAL A 378
VAL A 330
ASP A 335
 None
 0.90A 1iwiA-3jxvA:
undetectable		 1iwiA-3jxvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ko7 D-TYROSYL-TRNA(TYR)
DEACYLASE

(Plasmodium
falciparum) 		PF02580
(Tyr_Deacylase) 		4 LEU A  79
VAL A  76
VAL A 151
ASP A 148
 None
 0.94A 1iwiA-3ko7A:
undetectable		 1iwiA-3ko7A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mh9 LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		no annotation 4 THR C  52
LEU C 204
VAL C 194
VAL C 172
 None
 0.92A 1iwiA-3mh9C:
undetectable		 1iwiA-3mh9C:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no3 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		4 LEU A 149
VAL A 144
VAL A  72
VAL A  62
 None
 0.96A 1iwiA-3no3A:
undetectable		 1iwiA-3no3A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orf DIHYDROPTERIDINE
REDUCTASE

(Dictyostelium
discoideum) 		PF00106
(adh_short) 		4 LEU A 193
VAL A 196
VAL A   7
VAL A  72
 None
 0.84A 1iwiA-3orfA:
undetectable		 1iwiA-3orfA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os7 GALACTOSE
MUTAROTASE-LIKE
PROTEIN

(Clostridium
acetobutylicum) 		PF01263
(Aldose_epim) 		4 LEU A  30
VAL A  39
VAL A 118
VAL A 132
 None
 0.92A 1iwiA-3os7A:
undetectable		 1iwiA-3os7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxn PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		4 TYR A 291
THR A 123
VAL A 224
VAL A 190
 None
 0.94A 1iwiA-3oxnA:
undetectable		 1iwiA-3oxnA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A 374
VAL A 188
ASP A 159
VAL A 157
 None
None
None
FAD  A 601 (-4.1A)
 0.92A 1iwiA-3p4sA:
undetectable		 1iwiA-3p4sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 PHE A1532
LEU A1511
VAL A1498
VAL A1489
 None
None
None
GOL  A   1 ( 4.7A)
 0.94A 1iwiA-3pvlA:
undetectable		 1iwiA-3pvlA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsq CAPSID POLYPROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		5 PHE A 638
THR A 591
LEU A 626
VAL A 484
VAL A 438
 None
 1.34A 1iwiA-3qsqA:
undetectable		 1iwiA-3qsqA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rku OXIDOREDUCTASE
YMR226C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		4 LEU A  11
VAL A 151
ASP A 149
VAL A 100
 None
 0.85A 1iwiA-3rkuA:
undetectable		 1iwiA-3rkuA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sim PROTEIN, FAMILY 18
CHITINASE

(Crocus vernus) 		PF00704
(Glyco_hydro_18) 		4 PHE A  94
LEU A 172
VAL A 103
VAL A  99
 None
 0.90A 1iwiA-3simA:
undetectable		 1iwiA-3simA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		4 THR A  71
LEU A 152
VAL A 150
VAL A 103
 None
 0.93A 1iwiA-3skvA:
undetectable		 1iwiA-3skvA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		4 PHE A 586
LEU A 590
VAL A 444
ASP A 441
 None
 0.95A 1iwiA-3t6gA:
undetectable		 1iwiA-3t6gA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9n SMALL-CONDUCTANCE
MECHANOSENSITIVE
CHANNEL

(Caldanaerobacter
subterraneus) 		PF00924
(MS_channel) 		4 PHE A 188
VAL A 256
VAL A 221
VAL A 236
 None
 0.94A 1iwiA-3t9nA:
undetectable		 1iwiA-3t9nA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN NUP82

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 206
THR A 200
LEU A 175
ASP A 204
 None
 0.96A 1iwiA-3tknA:
undetectable		 1iwiA-3tknA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		4 LEU A  74
VAL A  77
VAL A  90
VAL A   9
 None
 0.93A 1iwiA-3tovA:
undetectable		 1iwiA-3tovA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE

(Acetobacter
aceti) 		PF02515
(CoA_transf_3) 		5 LEU A 195
VAL A 199
VAL A  39
ASP A  18
VAL A  16
 None
 1.41A 1iwiA-3ubmA:
undetectable		 1iwiA-3ubmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umf ADENYLATE KINASE

(Schistosoma
mansoni) 		PF00406
(ADK) 		4 PHE A  13
TYR A  96
LEU A  74
VAL A 110
 None
 0.88A 1iwiA-3umfA:
undetectable		 1iwiA-3umfA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv6 GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 PHE A  93
VAL A  47
VAL A 120
VAL A 112
 None
 0.91A 1iwiA-3wv6A:
undetectable		 1iwiA-3wv6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 PHE A 484
LEU A 325
VAL A 324
VAL A 530
 None
 0.95A 1iwiA-4ah6A:
undetectable		 1iwiA-4ah6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		4 VAL A  27
VAL A 146
ASP A 144
VAL A 138
 None
 0.79A 1iwiA-4ap3A:
undetectable		 1iwiA-4ap3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 PHE A 178
VAL A 194
ASP A 185
VAL A 187
 None
 0.98A 1iwiA-4bp8A:
undetectable		 1iwiA-4bp8A:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		6 TYR A  98
THR A 103
LEU A 252
VAL A 303
ASP A 305
VAL A 404
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
GOL  A1419 (-3.5A)
 0.48A 1iwiA-4c9mA:
58.3		 1iwiA-4c9mA:
45.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 TYR A  98
THR A 103
LEU A 252
VAL A 404
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
GOL  A1419 (-3.5A)
 0.78A 1iwiA-4c9mA:
58.3		 1iwiA-4c9mA:
45.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		4 LEU A 223
VAL A 136
ASP A 163
VAL A 165
 None
 0.95A 1iwiA-4cyfA:
undetectable		 1iwiA-4cyfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 THR A 593
LEU A 508
VAL A 511
VAL A 721
 None
 0.74A 1iwiA-4czwA:
undetectable		 1iwiA-4czwA:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 PHE A  87
THR A 101
LEU A 250
VAL A 301
VAL A 402
 None
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
PEG  A 502 ( 4.5A)
None
 0.86A 1iwiA-4dxyA:
51.7		 1iwiA-4dxyA:
46.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT

(Streptococcus
pneumoniae) 		PF02518
(HATPase_c) 		4 LEU A 204
VAL A  76
ASP A  78
VAL A  66
 None
None
0RA  A 301 (-3.6A)
None
 0.96A 1iwiA-4em7A:
undetectable		 1iwiA-4em7A:
19.86