SIMILAR PATTERNS OF AMINO ACIDS FOR 1ITU_A_CILA451
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e5d | RUBREDOXIN:OXYGENOXIDOREDUCTASE (Desulfovibriogigas) |
PF00258(Flavodoxin_1)PF00753(Lactamase_B) | 5 | GLU A 81HIS A 24HIS A 146ASP A 165PRO A 224 | FEO A 404 (-2.6A)OXY A 405 ( 4.8A)FEO A 404 (-3.3A)FEO A 404 ( 2.3A)None | 1.35A | 1ituA-1e5dA:undetectable | 1ituA-1e5dA:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6o | TATD-RELATEDDEOXYRIBONUCLEASE (Thermotogamaritima) |
PF01026(TatD_DNase) | 5 | GLU A 90HIS A 61HIS A 126HIS A 151ASP A 201 | None | 0.94A | 1ituA-1j6oA:14.3 | 1ituA-1j6oA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6o | TATD-RELATEDDEOXYRIBONUCLEASE (Thermotogamaritima) |
PF01026(TatD_DNase) | 5 | HIS A 61HIS A 126HIS A 151ASP A 201PRO A 203 | None | 1.49A | 1ituA-1j6oA:14.3 | 1ituA-1j6oA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m68 | HYPOTHETICAL PROTEINYCDX (Escherichiacoli) |
PF02811(PHP) | 6 | ASP A 192GLU A 73HIS A 40HIS A 101HIS A 131ASN A 134 | ZN A 302 (-2.6A) ZN A 303 ( 2.3A) ZN A 301 (-3.2A) ZN A 303 (-3.2A) ZN A 303 (-3.4A)None | 1.12A | 1ituA-1m68A:8.1 | 1ituA-1m68A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m68 | HYPOTHETICAL PROTEINYCDX (Escherichiacoli) |
PF02811(PHP) | 5 | GLU A 73HIS A 101HIS A 7ASN A 158ASP A 192 | ZN A 303 ( 2.3A) ZN A 303 (-3.2A) ZN A 302 (-3.2A)None ZN A 302 (-2.6A) | 1.38A | 1ituA-1m68A:8.1 | 1ituA-1m68A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o12 | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Thermotogamaritima) |
PF01979(Amidohydro_1) | 5 | GLU A 115HIS A 127HIS A 176HIS A 197ASP A 255 | FE A 401 (-2.6A) FE A 401 ( 4.8A) FE A 401 (-3.3A) FE A 401 (-3.5A)None | 1.29A | 1ituA-1o12A:14.7 | 1ituA-1o12A:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p1m | HYPOTHETICAL PROTEINTM0936 (Thermotogamaritima) |
PF01979(Amidohydro_1) | 5 | HIS A 173HIS A 200HIS A 55ASN A 250ASP A 279 | None NI A9001 (-3.4A) NI A9001 (-3.3A)None NI A9001 (-2.6A) | 1.21A | 1ituA-1p1mA:5.4 | 1ituA-1p1mA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkm | METHIONINEAMINOPEPTIDASE (Pyrococcusfuriosus) |
PF00557(Peptidase_M24) | 5 | ASP A 82GLU A 187HIS A 153TYR A 265PRO A 51 | MN A 297 ( 1.7A) MN A 296 ( 2.6A) MN A 296 ( 3.3A)MET A1298 ( 4.7A)None | 1.14A | 1ituA-1wkmA:undetectable | 1ituA-1wkmA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkm | METHIONINEAMINOPEPTIDASE (Pyrococcusfuriosus) |
PF00557(Peptidase_M24) | 5 | ASP A 82HIS A 153HIS A 161TYR A 265PRO A 51 | MN A 297 ( 1.7A) MN A 296 ( 3.3A)MET A1298 (-4.0A)MET A1298 ( 4.7A)None | 1.43A | 1ituA-1wkmA:undetectable | 1ituA-1wkmA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ycg | NITRIC OXIDEREDUCTASE (Moorellathermoacetica) |
PF00258(Flavodoxin_1)PF00753(Lactamase_B) | 5 | GLU A 83HIS A 25HIS A 148TYR A 195ASP A 167 | EDO A 602 (-2.2A)EDO A 602 ( 2.9A)FEO A 501 (-2.8A)NoneFEO A 501 ( 2.4A) | 1.37A | 1ituA-1ycgA:undetectable | 1ituA-1ycgA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yix | DEOXYRIBONUCLEASEYCFH (Escherichiacoli) |
PF01026(TatD_DNase) | 5 | GLU A 94HIS A 67HIS A 130HIS A 155ASP A 205 | ZN A 604 ( 2.5A)None ZN A 604 (-3.3A) ZN A 604 ( 3.2A) ZN A 601 (-2.8A) | 0.99A | 1ituA-1yixA:10.0 | 1ituA-1yixA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yix | DEOXYRIBONUCLEASEYCFH (Escherichiacoli) |
PF01026(TatD_DNase) | 5 | HIS A 67HIS A 130HIS A 155ASP A 205PRO A 207 | None ZN A 604 (-3.3A) ZN A 604 ( 3.2A) ZN A 601 (-2.8A)None | 1.43A | 1ituA-1yixA:10.0 | 1ituA-1yixA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z8l | GLUTAMATECARBOXYPEPTIDASE II (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | GLU A 425HIS A 553HIS A 377ASN A 519ASP A 453 | ZN A1752 (-2.5A) ZN A1752 (-3.3A) ZN A1751 (-3.3A) ZN A1751 (-3.7A) ZN A1751 (-2.0A) | 1.48A | 1ituA-1z8lA:undetectable | 1ituA-1z8lA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zzm | PUTATIVEDEOXYRIBONUCLEASEYJJV (Escherichiacoli) |
PF01026(TatD_DNase) | 5 | GLU A 97HIS A 66HIS A 133HIS A 157ASP A 207 | ZN A 401 ( 2.3A)P33 A 501 (-4.0A) ZN A 402 (-3.1A) ZN A 402 (-3.3A) ZN A 401 (-3.2A) | 0.99A | 1ituA-1zzmA:14.6 | 1ituA-1zzmA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2adu | METHIONINEAMINOPEPTIDASE 2 (Homo sapiens) |
PF00557(Peptidase_M24) | 5 | ASP A 251HIS A 331HIS A 339TYR A 444PRO A 220 | CO A 501 ( 1.9A) CO A 502 ( 3.2A)R20 A 906 (-4.0A)R20 A 906 (-3.5A)None | 1.44A | 1ituA-2aduA:undetectable | 1ituA-2aduA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2az4 | HYPOTHETICAL PROTEINEF2904 (Enterococcusfaecalis) |
PF12706(Lactamase_B_2) | 5 | HIS A 97HIS A 92HIS A 167TYR A 261ASP A 168 | ZN A 602 (-3.3A) ZN A 601 (-3.4A) ZN A 601 (-3.4A)NoneNone | 1.39A | 1ituA-2az4A:undetectable | 1ituA-2az4A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fgn | PHOSPHOLIPASE C (Bacillus cereus) |
PF00882(Zn_dep_PLPC) | 5 | TYR A 119HIS A 69HIS A 14ASN A 12TYR A 52 | None ZN A 246 (-3.3A) ZN A 248 (-3.3A)NoneNone | 0.99A | 1ituA-2fgnA:undetectable | 1ituA-2fgnA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gfq | UPF0204 PROTEINPH0006 (Pyrococcushorikoshii) |
PF04414(tRNA_deacylase) | 5 | TYR A 200GLU A 137HIS A 80HIS A 140TYR A 102 | None MG A2018 ( 4.6A)None MG A2018 ( 4.6A)None | 1.45A | 1ituA-2gfqA:undetectable | 1ituA-2gfqA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gzx | PUTATIVE TATDRELATED DNASE (Staphylococcusaureus) |
PF01026(TatD_DNase) | 6 | GLU A 92HIS A 63HIS A 128HIS A 153ASP A 204PRO A 206 | NI A 300 ( 2.8A)None NI A 299 (-3.4A) NI A 299 (-3.5A) NI A 300 ( 2.9A)None | 1.37A | 1ituA-2gzxA:14.3 | 1ituA-2gzxA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p50 | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Escherichiacoli) |
PF01979(Amidohydro_1) | 5 | GLU A 131HIS A 143HIS A 195HIS A 216ASN A 219 | ZN A 601 (-2.3A)None ZN A 601 (-3.3A) ZN A 601 (-3.4A)None | 1.08A | 1ituA-2p50A:15.5 | 1ituA-2p50A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p50 | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Escherichiacoli) |
PF01979(Amidohydro_1) | 5 | GLU A 131HIS A 143HIS A 195HIS A 216ASP A 273 | ZN A 601 (-2.3A)None ZN A 601 (-3.3A) ZN A 601 (-3.4A) ZN A 601 ( 4.5A) | 1.13A | 1ituA-2p50A:15.5 | 1ituA-2p50A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rag | DIPEPTIDASE (Caulobactervibrioides) |
PF01244(Peptidase_M19) | 10 | ASP A 55TYR A 98GLU A 159HIS A 186HIS A 229HIS A 250ARG A 261ASN A 281TYR A 284ASP A 360 | ZN A 418 ( 2.2A)None ZN A 418 ( 2.3A)None ZN A 419 ( 3.5A) ZN A 419 ( 3.4A) CL A 420 ( 4.6A)None CL A 420 ( 4.8A) CL A 420 ( 4.1A) | 0.46A | 1ituA-2ragA:46.7 | 1ituA-2ragA:27.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rag | DIPEPTIDASE (Caulobactervibrioides) |
PF01244(Peptidase_M19) | 5 | TYR A 98GLU A 159HIS A 186HIS A 53ASP A 360 | None ZN A 418 ( 2.3A)None ZN A 418 ( 3.4A) CL A 420 ( 4.1A) | 1.12A | 1ituA-2ragA:46.7 | 1ituA-2ragA:27.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9m | POLYMERASE X (Deinococcusradiodurans) |
PF14520(HHH_5)PF14716(HHH_8) | 5 | ASP A 516GLU A 401HIS A 364HIS A 428HIS A 456 | ZN A1566 (-2.5A) ZN A1567 ( 2.4A) ZN A1565 (-3.2A) ZN A1567 (-3.4A) ZN A1567 (-3.6A) | 0.91A | 1ituA-2w9mA:2.9 | 1ituA-2w9mA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y1h | PUTATIVEDEOXYRIBONUCLEASETATDN3 (Homo sapiens) |
PF01026(TatD_DNase) | 5 | GLU A 107HIS A 70HIS A 147HIS A 170ASP A 218 | ZN A1274 (-2.4A)PO4 A1275 (-3.8A) ZN A1273 ( 3.1A) ZN A1273 (-3.2A)PO4 A1275 ( 2.7A) | 1.00A | 1ituA-2y1hA:14.7 | 1ituA-2y1hA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yb4 | AMIDOHYDROLASE (Chromobacteriumviolaceum) |
PF02811(PHP) | 5 | GLU A 64HIS A 39HIS A 75HIS A 191ASP A 248 | NoneSO4 A1289 (-4.1A)NoneNoneNone | 1.42A | 1ituA-2yb4A:3.3 | 1ituA-2yb4A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z4g | HISTIDINOLPHOSPHATASE (Thermusthermophilus) |
PF02811(PHP)PF13263(PHP_C) | 5 | ASP A 46HIS A 13HIS A 108ASP A 82PRO A 40 | None ZN A 501 (-3.3A) FE A 502 (-3.5A)NoneNone | 1.15A | 1ituA-2z4gA:6.9 | 1ituA-2z4gA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z4g | HISTIDINOLPHOSPHATASE (Thermusthermophilus) |
PF02811(PHP)PF13263(PHP_C) | 5 | GLU A 80HIS A 5ASN A 191TYR A 203ASP A 224 | FE A 502 ( 2.6A) FE A 503 (-3.5A)NoneNone FE A 503 (-2.5A) | 1.22A | 1ituA-2z4gA:6.9 | 1ituA-2z4gA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z4g | HISTIDINOLPHOSPHATASE (Thermusthermophilus) |
PF02811(PHP)PF13263(PHP_C) | 5 | GLU A 80HIS A 38HIS A 108ASP A 116PRO A 118 | FE A 502 ( 2.6A) ZN A 501 (-3.2A) FE A 502 (-3.5A)NoneNone | 1.41A | 1ituA-2z4gA:6.9 | 1ituA-2z4gA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z4g | HISTIDINOLPHOSPHATASE (Thermusthermophilus) |
PF02811(PHP)PF13263(PHP_C) | 5 | HIS A 108HIS A 5ASN A 191TYR A 203ASP A 224 | FE A 502 (-3.5A) FE A 503 (-3.5A)NoneNone FE A 503 (-2.5A) | 1.33A | 1ituA-2z4gA:6.9 | 1ituA-2z4gA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3auo | DNA POLYMERASE BETAFAMILY (X FAMILY) (Thermusthermophilus) |
PF14520(HHH_5)PF14716(HHH_8)PF14791(DNA_pol_B_thumb) | 5 | GLU A 413HIS A 374HIS A 468TYR A 503ASP A 501 | ZN A 579 (-2.2A)None ZN A 579 (-3.4A)NoneNone | 1.15A | 1ituA-3auoA:7.4 | 1ituA-3auoA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dcp | HISTIDINOL-PHOSPHATASE (Listeriamonocytogenes) |
PF02811(PHP)PF13263(PHP_C) | 6 | GLU A 93HIS A 123HIS A 6ASN A 224TYR A 237ASP A 258 | FE A 311 ( 2.6A) FE A 310 (-3.3A) FE A 311 (-3.3A)NoneNone FE A 311 (-2.6A) | 1.28A | 1ituA-3dcpA:7.5 | 1ituA-3dcpA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dcp | HISTIDINOL-PHOSPHATASE (Listeriamonocytogenes) |
PF02811(PHP)PF13263(PHP_C) | 5 | GLU A 93HIS A 123HIS A 6TYR A 237ASP A 258 | FE A 311 ( 2.6A) FE A 310 (-3.3A) FE A 311 (-3.3A)None FE A 311 (-2.6A) | 1.45A | 1ituA-3dcpA:7.5 | 1ituA-3dcpA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egj | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Vibrio cholerae) |
PF01979(Amidohydro_1) | 5 | GLU A 128HIS A 140HIS A 192HIS A 213ASP A 270 | NI A 401 (-2.7A) NI A 401 (-4.4A) NI A 401 (-3.4A) NI A 401 (-3.7A) NI A 401 ( 4.8A) | 1.23A | 1ituA-3egjA:15.4 | 1ituA-3egjA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdg | DIPEPTIDASE AC.METALLO PEPTIDASE.MEROPS FAMILY M19 (Rhodobactersphaeroides) |
PF01244(Peptidase_M19) | 8 | ASP A 13TYR A 56GLU A 137HIS A 210HIS A 231ARG A 242ASN A 262ASP A 304 | MG A 357 (-1.8A)None MG A 357 ( 2.4A) MG A 356 (-3.4A) MG A 356 (-3.5A) MG A 356 ( 4.9A)None MG A 356 ( 4.0A) | 0.24A | 1ituA-3fdgA:44.4 | 1ituA-3fdgA:29.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gg7 | UNCHARACTERIZEDMETALLOPROTEIN (Deinococcusradiodurans) |
PF01026(TatD_DNase) | 5 | GLU A 84HIS A 58HIS A 122HIS A 146ASP A 194 | MN A 253 (-2.6A)MRD A 257 (-3.5A)None MN A 253 (-4.3A) MN A 253 (-2.7A) | 1.11A | 1ituA-3gg7A:12.5 | 1ituA-3gg7A:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3guw | UNCHARACTERIZEDPROTEIN AF_1765 (Archaeoglobusfulgidus) |
PF01026(TatD_DNase) | 5 | GLU A 98HIS A 129HIS A 6ASN A 205ASP A 207 | ZN A 301 ( 2.9A) ZN A 302 (-3.2A) ZN A 301 (-3.0A)None ZN A 301 (-2.9A) | 1.07A | 1ituA-3guwA:5.7 | 1ituA-3guwA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lu2 | LMO2462 PROTEIN (Listeriamonocytogenes) |
PF01244(Peptidase_M19) | 7 | ASP A 9GLU A 105HIS A 172HIS A 192ARG A 203ASP A 261PRO A 266 | ZN A 310 (-2.7A) ZN A 310 ( 4.0A) ZN A 309 (-4.3A) ZN A 309 (-4.6A)None ZN A 309 (-3.7A)None | 0.62A | 1ituA-3lu2A:42.7 | 1ituA-3lu2A:26.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdu | N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | TYR A 121HIS A 206HIS A 232HIS A 56ASP A 320 | NGQ A 455 (-3.8A)NGQ A 455 (-3.9A) ZN A 454 (-3.3A) ZN A 454 (-3.3A) ZN A 454 (-2.9A) | 1.13A | 1ituA-3mduA:11.3 | 1ituA-3mduA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rcm | TATD FAMILYHYDROLASE (Pseudomonasputida) |
PF01026(TatD_DNase) | 5 | GLU A 97HIS A 68HIS A 133ASP A 209PRO A 211 | ZN A 288 ( 2.3A)CIT A 289 (-4.0A) ZN A 288 ( 3.2A)CIT A 289 (-3.3A)None | 1.38A | 1ituA-3rcmA:13.9 | 1ituA-3rcmA:25.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rcm | TATD FAMILYHYDROLASE (Pseudomonasputida) |
PF01026(TatD_DNase) | 5 | GLU A 97HIS A 68HIS A 133HIS A 158PRO A 211 | ZN A 288 ( 2.3A)CIT A 289 (-4.0A) ZN A 288 ( 3.2A) ZN A 288 ( 3.2A)None | 1.36A | 1ituA-3rcmA:13.9 | 1ituA-3rcmA:25.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rhg | PUTATIVEPHOPHOTRIESTERASE (Proteusmirabilis) |
PF02126(PTE) | 5 | TYR A 126GLU A 166HIS A 199HIS A 23ASP A 294 | UNL A 372 (-4.3A) ZN A 368 (-2.5A) ZN A 368 (-3.1A) ZN A 367 ( 3.2A)CAC A 370 (-2.4A) | 1.01A | 1ituA-3rhgA:15.7 | 1ituA-3rhgA:21.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3s2j | DIPEPTIDASE (Streptomycescoelicolor) |
PF01244(Peptidase_M19) | 5 | ASP A 22GLU A 123HIS A 191ASP A 320PRO A 325 | ZN A 402 ( 2.2A) ZN A 402 (-2.4A) ZN A 403 ( 3.2A)L3A A 401 (-3.1A)EDO A 407 (-4.2A) | 1.33A | 1ituA-3s2jA:57.9 | 1ituA-3s2jA:41.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3s2j | DIPEPTIDASE (Streptomycescoelicolor) |
PF01244(Peptidase_M19) | 9 | ASP A 22TYR A 68GLU A 123HIS A 150HIS A 191HIS A 212ARG A 223ASP A 320PRO A 325 | ZN A 402 ( 2.2A)L3A A 401 ( 3.6A) ZN A 402 (-2.4A)EDO A 409 ( 3.7A) ZN A 403 ( 3.2A) ZN A 403 ( 3.3A)L3A A 401 (-4.0A)L3A A 401 (-3.1A)EDO A 407 (-4.2A) | 0.44A | 1ituA-3s2jA:57.9 | 1ituA-3s2jA:41.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3s2j | DIPEPTIDASE (Streptomycescoelicolor) |
PF01244(Peptidase_M19) | 6 | TYR A 68GLU A 123HIS A 150HIS A 20ASP A 320PRO A 325 | L3A A 401 ( 3.6A) ZN A 402 (-2.4A)EDO A 409 ( 3.7A) ZN A 402 ( 3.3A)L3A A 401 (-3.1A)EDO A 407 (-4.2A) | 1.17A | 1ituA-3s2jA:57.9 | 1ituA-3s2jA:41.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8l | ADENINE DEAMINASE 2 (Agrobacteriumfabrum) |
PF01979(Amidohydro_1)PF13382(Adenine_deam_C) | 5 | GLU A 187HIS A 239HIS A 92HIS A 94ASP A 290 | UNX A 606 ( 2.6A)UNX A 606 ( 3.6A)UNX A 608 ( 3.2A)UNX A 608 ( 3.4A)None | 1.34A | 1ituA-3t8lA:4.0 | 1ituA-3t8lA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wy2 | ALPHA-GLUCOSIDASE (Halomonas sp.H11) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | HIS A 332ARG A 200ASN A 331TYR A 295ASP A 333 | BGC A 605 (-3.9A)BGC A 605 (-3.0A)NoneNoneBGC A 605 (-2.9A) | 1.35A | 1ituA-3wy2A:5.5 | 1ituA-3wy2A:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0l | AMIDOHYDROLASE (Brucellaabortus) |
PF01979(Amidohydro_1) | 5 | TYR A 126HIS A 212HIS A 237HIS A 61ASP A 325 | NoneNone FE A 501 (-3.5A) FE A 501 (-3.4A) FE A 501 (-2.8A) | 1.12A | 1ituA-4f0lA:6.4 | 1ituA-4f0lA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0s | 5-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE DEAMINASE (Chromobacteriumviolaceum) |
PF01979(Amidohydro_1) | 5 | HIS A 192HIS A 219HIS A 70ASN A 278ASP A 307 | NOS A 501 (-4.0A)NOS A 501 (-3.5A)NoneNoneNOS A 501 (-2.8A) | 1.29A | 1ituA-4f0sA:5.3 | 1ituA-4f0sA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gk8 | HISTIDINOL-PHOSPHATASE (Lactococcuslactis) |
PF02811(PHP) | 5 | GLU A 81HIS A 109HIS A 9ASN A 195ASP A 228 | ZN A 301 (-2.5A) ZN A 301 ( 3.3A) ZN A 303 (-3.3A)None ZN A 303 ( 2.6A) | 1.26A | 1ituA-4gk8A:7.7 | 1ituA-4gk8A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kav | YHBX/YHJW/YIJP/YJDBFAMILY PROTEIN (Neisseriameningitidis) |
PF00884(Sulfatase) | 5 | ASP A 324HIS A 453HIS A 465HIS A 383TYR A 387 | TPO A 280 ( 3.9A) ZN A 601 ( 3.2A)TPO A 280 (-3.9A) NA A 606 ( 3.7A)None | 1.50A | 1ituA-4kavA:undetectable | 1ituA-4kavA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ook | METHIONINEAMINOPEPTIDASE 2 (Mycobacteriumtuberculosis) |
PF00557(Peptidase_M24) | 5 | TYR A 97HIS A 212HIS A 205ASN A 144ASP A 131 | NoneNone CO A 302 (-3.2A)None CO A 301 (-1.9A) | 1.34A | 1ituA-4ookA:undetectable | 1ituA-4ookA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pe8 | TAT-LINKED QUALITYCONTROL PROTEIN TATD (Escherichiacoli) |
PF01026(TatD_DNase) | 5 | GLU A 91HIS A 62HIS A 127ASP A 203PRO A 205 | None | 1.46A | 1ituA-4pe8A:13.5 | 1ituA-4pe8A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pe8 | TAT-LINKED QUALITYCONTROL PROTEIN TATD (Escherichiacoli) |
PF01026(TatD_DNase) | 5 | GLU A 91HIS A 62HIS A 127HIS A 152PRO A 205 | None | 1.36A | 1ituA-4pe8A:13.5 | 1ituA-4pe8A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uwa | RYANODINE RECEPTOR 1 (Oryctolaguscuniculus) |
PF00622(SPRY)PF01365(RYDR_ITPR)PF02026(RyR)PF02815(MIR)PF08709(Ins145_P3_rec) | 5 | HIS A 904HIS A 879ASN A 921TYR A 920PRO A 916 | None | 1.48A | 1ituA-4uwaA:undetectable | 1ituA-4uwaA:7.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzb | NITROGENASEMOLYBDENUM-IRONPROTEIN ALPHA CHAIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 5 | HIS A 362HIS A 451ARG A 359TYR A 229ASP A 228 | NoneNoneICS A1496 (-3.9A)ICS A1496 (-4.1A)None | 1.36A | 1ituA-4wzbA:undetectable | 1ituA-4wzbA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zr0 | CERAMIDE VERY LONGCHAIN FATTY ACIDHYDROXYLASE SCS7 (Saccharomycescerevisiae) |
PF04116(FA_hydroxylase) | 5 | HIS A 326HIS A 345HIS A 348TYR A 350PRO A 175 | ZN A 401 (-3.4A) ZN A 401 (-3.5A) ZN A 402 (-3.3A)NoneNone | 1.36A | 1ituA-4zr0A:undetectable | 1ituA-4zr0A:19.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lx0 | DIPEPTIDASE (Aspergillusfumigatus) |
PF01244(Peptidase_M19) | 7 | ASP A 25GLU A 134HIS A 161HIS A 203HIS A 224ARG A 235ASP A 294 | FE A 401 (-2.0A) FE A 401 ( 2.4A)None FE A 402 (-3.5A) FE A 402 (-3.5A)None FE A 402 (-3.9A) | 0.30A | 1ituA-5lx0A:55.2 | 1ituA-5lx0A:38.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oar | BETA-HEXOSAMINIDASE (Aspergillusoryzae) |
no annotation | 5 | ASP B 345GLU B 269HIS B 341HIS B 217HIS B 219 | NGT B 707 (-3.9A)NoneNoneNoneNone | 1.26A | 1ituA-5oarB:6.7 | 1ituA-5oarB:14.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgw | ISOASPARTYLDIPEPTIDASE (Colwelliapsychrerythraea) |
no annotation | 5 | TYR A 140GLU A 166HIS A 205HIS A 71ASP A 293 | None ZN A 402 ( 2.4A) ZN A 402 (-3.2A) ZN A 401 (-3.4A) ZN A 401 (-2.6A) | 1.10A | 1ituA-5xgwA:15.3 | 1ituA-5xgwA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6a8l | - (-) |
no annotation | 5 | GLU A 64HIS A 62HIS A 71ASN A 72ASP A 53 | ZN A 200 (-2.4A)None ZN A 200 (-3.4A)None ZN A 200 (-2.7A) | 1.30A | 1ituA-6a8lA:undetectable | 1ituA-6a8lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fv4 | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Mycolicibacteriumsmegmatis) |
no annotation | 5 | GLU A 122HIS A 134HIS A 188HIS A 209ASN A 212 | CD A 403 (-2.4A)16G A 402 (-4.0A) CD A 403 ( 3.6A) CD A 403 ( 3.7A)16G A 402 (-3.6A) | 1.17A | 1ituA-6fv4A:14.4 | 1ituA-6fv4A:11.71 |