SIMILAR PATTERNS OF AMINO ACIDS FOR 1ISM_B_NCAB305_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)


(Hordeum vulgare)
PF01373
(Glyco_hydro_14)
4 HIS A 271
LEU A 133
ASP A 138
PHE A  90
None
1.12A 1ismB-1b1yA:
0.8
1ismB-1b1yA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btc BETA-AMYLASE

(Glycine max)
PF01373
(Glyco_hydro_14)
4 HIS A 273
LEU A 135
ASP A 140
PHE A  92
None
1.07A 1ismB-1btcA:
1.2
1ismB-1btcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR


(Homo sapiens)
PF13374
(TPR_10)
PF13432
(TPR_16)
4 LEU A 595
SER A 592
ASP A 590
PHE A 598
None
1.27A 1ismB-1fchA:
undetectable
1ismB-1fchA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g65 PROTEASOME COMPONENT
PUP3


(Saccharomyces
cerevisiae)
PF00227
(Proteasome)
4 LEU I 134
SER I 131
ASP I 132
PHE I 124
None
MG  I 201 (-2.2A)
None
None
1.24A 1ismB-1g65I:
undetectable
1ismB-1g65I:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare)
PF00332
(Glyco_hydro_17)
4 HIS A 257
LEU A 205
SER A 204
ASP A 207
None
1.16A 1ismB-1ghsA:
undetectable
1ismB-1ghsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare)
PF00332
(Glyco_hydro_17)
4 LEU A 205
SER A 204
ASP A 207
PHE A 130
None
1.28A 1ismB-1ghsA:
undetectable
1ismB-1ghsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE


(Schizosaccharomyces
pombe)
PF03372
(Exo_endo_phos)
4 LEU A 761
SER A 762
TRP A 814
PHE A 790
None
1.04A 1ismB-1i9zA:
undetectable
1ismB-1i9zA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ism BONE MARROW STROMAL
CELL ANTIGEN 1


(Homo sapiens)
PF02267
(Rib_hydrolayse)
7 TRP A  77
HIS A  81
LEU A  97
SER A  98
ASP A 107
TRP A 140
PHE A 173
NCA  A 303 (-4.4A)
NCA  A 303 (-4.1A)
NCA  A 303 (-4.3A)
NCA  A 303 (-3.9A)
NCA  A 303 (-4.4A)
NCA  A 303 (-4.0A)
NCA  A 303 (-3.7A)
0.12A 1ismB-1ismA:
40.7
1ismB-1ismA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv3 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Thermus
thermophilus)
PF02542
(YgbB)
4 HIS A  42
SER A  35
ASP A  36
PHE A  61
MG  A1561 (-3.0A)
MG  A1561 ( 4.7A)
None
None
1.27A 1ismB-1iv3A:
1.5
1ismB-1iv3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu2 LECTIN

(Vigna
unguiculata)
PF00139
(Lectin_legB)
4 HIS A 138
LEU A 127
SER A 128
ASP A 133
MN  A 302 (-3.7A)
A2G  A 254 ( 4.6A)
None
CA  A 301 ( 3.0A)
1.29A 1ismB-1lu2A:
undetectable
1ismB-1lu2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lyb CATHEPSIN D

(Homo sapiens)
PF00026
(Asp)
4 HIS A  77
LEU A  83
SER A  84
ASP A  75
None
1.24A 1ismB-1lybA:
undetectable
1ismB-1lybA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR


(Homo sapiens)
no annotation 4 LEU C 123
SER C 122
ASP C 110
PHE C 106
None
NAG  C 740 (-3.4A)
NAG  C 740 (-4.6A)
None
1.25A 1ismB-1ow0C:
undetectable
1ismB-1ow0C:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqb TRANSCARBOXYLASE 5S
SUBUNIT


(Propionibacterium
freudenreichii)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
4 HIS A 217
LEU A  28
SER A  27
ASP A  23
CO  A 529 (-3.3A)
None
None
CO  A 529 (-2.5A)
1.16A 1ismB-1rqbA:
undetectable
1ismB-1rqbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus)
PF03065
(Glyco_hydro_57)
PF09210
(DUF1957)
4 HIS A 300
LEU A 295
SER A 296
ASP A  90
None
1.15A 1ismB-1ufaA:
undetectable
1ismB-1ufaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT


(Thermotoga
maritima)
PF13393
(tRNA-synt_His)
4 LEU C 103
SER C 102
ASP C 105
PHE C 211
None
0.94A 1ismB-1usyC:
undetectable
1ismB-1usyC:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Saccharomyces
cerevisiae)
PF04095
(NAPRTase)
4 HIS A 232
SER A 297
ASP A 296
PHE A 278
None
1.09A 1ismB-1vlpA:
undetectable
1ismB-1vlpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE


(Clostridium
acetobutylicum)
PF13649
(Methyltransf_25)
4 LEU A  56
SER A  25
ASP A  26
PHE A  39
None
1.25A 1ismB-1y8cA:
undetectable
1ismB-1y8cA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2


(Pseudomonas
aeruginosa)
PF04095
(NAPRTase)
4 HIS A 226
SER A 290
ASP A 289
PHE A 271
SO4  A2001 (-3.7A)
None
SO4  A2001 ( 4.2A)
None
1.15A 1ismB-1yirA:
undetectable
1ismB-1yirA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuo HYPOTHETICAL PROTEIN
LOC92912


(Homo sapiens)
PF00179
(UQ_con)
4 LEU A 236
SER A 235
ASP A 238
PHE A 278
None
1.17A 1ismB-1zuoA:
undetectable
1ismB-1zuoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger)
PF00128
(Alpha-amylase)
PF09260
(DUF1966)
4 TRP A 348
SER A  25
ASP A  23
PHE A  19
None
1.16A 1ismB-2aaaA:
undetectable
1ismB-2aaaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR


(Homo sapiens)
PF00515
(TPR_1)
PF13432
(TPR_16)
4 LEU A 632
SER A 629
ASP A 627
PHE A 635
None
1.25A 1ismB-2c0lA:
undetectable
1ismB-2c0lA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE


(Homo sapiens)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
4 HIS A 167
LEU A 164
ASP A 652
PHE A 129
CU  A1742 (-3.2A)
None
None
None
1.07A 1ismB-2c11A:
undetectable
1ismB-2c11A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE


(Homo sapiens)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
4 HIS A 242
LEU A 516
SER A 497
PHE A 501
None
0.98A 1ismB-2c11A:
undetectable
1ismB-2c11A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE


(Acidithiobacillus
thiooxidans)
PF00180
(Iso_dh)
4 LEU A 341
SER A 342
ASP A 343
PHE A 152
None
1.26A 1ismB-2d4vA:
undetectable
1ismB-2d4vA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eg9 ADP-RIBOSYL CYCLASE
1


(Mus musculus)
PF02267
(Rib_hydrolayse)
4 TRP A 129
LEU A 149
ASP A 159
TRP A 193
None
0.86A 1ismB-2eg9A:
9.5
1ismB-2eg9A:
32.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT


(Thermus
aquaticus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
4 LEU A 625
SER A 469
ASP A 470
PHE A 668
None
1.17A 1ismB-2hpiA:
2.3
1ismB-2hpiA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jd4 LAMININ SUBUNIT
ALPHA-1


(Mus musculus)
PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2)
4 HIS A3053
LEU A3028
ASP A3040
PHE A2880
None
1.21A 1ismB-2jd4A:
undetectable
1ismB-2jd4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnv GENERAL SECRETION
PATHWAY PROTEIN C


(Dickeya
dadantii)
PF11356
(T2SSC)
4 LEU A  95
SER A  96
ASP A 161
PHE A 120
None
1.15A 1ismB-2lnvA:
undetectable
1ismB-2lnvA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii)
PF01095
(Pectinesterase)
4 TRP A 107
LEU A 100
SER A 105
ASP A 103
None
1.24A 1ismB-2ntbA:
undetectable
1ismB-2ntbA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA


(Vibrio cholerae)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
4 HIS A 209
LEU A  22
SER A  21
ASP A  17
ZN  A 601 (-3.4A)
None
None
ZN  A 601 (-2.6A)
1.14A 1ismB-2nx9A:
undetectable
1ismB-2nx9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN


(Haemophilus
influenzae)
PF01547
(SBP_bac_1)
4 HIS A 298
LEU A 149
SER A 150
ASP A 155
None
0.98A 1ismB-2o69A:
undetectable
1ismB-2o69A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Arabidopsis
thaliana)
PF02542
(YgbB)
4 HIS A  45
SER A  38
ASP A  39
PHE A  64
ZN  A 500 (-3.1A)
ZN  A 500 ( 4.6A)
None
None
1.21A 1ismB-2pmpA:
undetectable
1ismB-2pmpA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0x UNCHARACTERIZED
PROTEIN


(Trypanosoma
brucei)
PF08538
(DUF1749)
4 LEU A  51
SER A  50
TRP A  43
PHE A  70
None
1.06A 1ismB-2q0xA:
undetectable
1ismB-2q0xA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN


(Rhizobium etli)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 HIS A 749
LEU A 554
SER A 553
ASP A 549
ZN  A1157 (-3.3A)
None
None
ZN  A1157 (-2.6A)
1.18A 1ismB-2qf7A:
undetectable
1ismB-2qf7A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmw PREPHENATE
DEHYDRATASE


(Staphylococcus
aureus)
PF00800
(PDT)
4 LEU A 214
SER A 215
ASP A 236
PHE A 188
None
1.15A 1ismB-2qmwA:
undetectable
1ismB-2qmwA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana)
PF00067
(p450)
5 HIS A 342
LEU A 513
SER A 512
ASP A 496
PHE A 489
None
1.18A 1ismB-2rchA:
undetectable
1ismB-2rchA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxb DNA REPAIR PROTEIN
RHP9


(Schizosaccharomyces
pombe)
PF00533
(BRCT)
4 LEU A 158
SER A 157
ASP A 160
PHE A  61
None
1.05A 1ismB-2vxbA:
undetectable
1ismB-2vxbA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE


(Thermotoga
maritima)
PF00483
(NTP_transferase)
4 HIS A 110
LEU A   7
ASP A 109
PHE A 193
None
GTP  A 601 (-3.7A)
GTP  A 601 ( 3.7A)
None
1.27A 1ismB-2x60A:
undetectable
1ismB-2x60A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE


(Escherichia
coli)
PF03588
(Leu_Phe_trans)
4 LEU A  38
SER A  34
ASP A  32
TRP A  58
None
0.99A 1ismB-2z3kA:
undetectable
1ismB-2z3kA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Mus musculus)
PF11921
(DUF3439)
PF13855
(LRR_8)
4 LEU B 153
SER B 154
ASP B 177
PHE B 150
None
1.19A 1ismB-3a79B:
2.2
1ismB-3a79B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE


(Streptococcus
mutans)
PF02153
(PDH)
4 HIS A  26
LEU A 166
SER A 167
ASP A 164
None
1.17A 1ismB-3b1fA:
3.0
1ismB-3b1fA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL


(Homo sapiens)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
4 HIS A 773
LEU A 577
SER A 576
ASP A 572
MN  A2001 (-3.8A)
None
None
MN  A2001 (-3.0A)
1.17A 1ismB-3bg9A:
undetectable
1ismB-3bg9A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh0 SAM DEPENDENT
METHYLTRANSFERASE


(Aquifex
aeolicus)
PF13847
(Methyltransf_31)
4 LEU A  21
SER A  19
ASP A  17
PHE A  24
None
1.22A 1ismB-3dh0A:
undetectable
1ismB-3dh0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzb PREPHENATE
DEHYDROGENASE


(Streptococcus
thermophilus)
PF02153
(PDH)
4 HIS A  26
LEU A 166
SER A 167
ASP A 164
None
1.16A 1ismB-3dzbA:
2.4
1ismB-3dzbA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq5 SKI-LIKE PROTEIN

(Homo sapiens)
PF02437
(Ski_Sno)
4 LEU A 202
SER A 199
ASP A 200
PHE A 213
None
1.15A 1ismB-3eq5A:
undetectable
1ismB-3eq5A:
15.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gc6 ECTO-NAD+
GLYCOHYDROLASE (CD38
MOLECULE)


(Bos taurus)
PF02267
(Rib_hydrolayse)
4 TRP A 118
LEU A 137
ASP A 147
TRP A 181
None
0.42A 1ismB-3gc6A:
27.4
1ismB-3gc6A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjc HEAT SHOCK PROTEIN
83-1


(Leishmania
major)
PF00183
(HSP90)
4 LEU A 210
SER A 206
ASP A 205
PHE A 215
None
1.25A 1ismB-3hjcA:
undetectable
1ismB-3hjcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus)
PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 HIS A 773
LEU A 577
SER A 576
ASP A 572
MN  A2002 (-3.4A)
None
None
MN  A2002 (-2.7A)
1.26A 1ismB-3ho8A:
undetectable
1ismB-3ho8A:
11.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i9k ADP-RIBOSYL CYCLASE

(Aplysia
californica)
PF02267
(Rib_hydrolayse)
4 TRP A  77
LEU A  97
TRP A 140
PHE A 174
None
0.31A 1ismB-3i9kA:
28.5
1ismB-3i9kA:
32.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 HIS A  79
LEU A  77
ASP A 199
PHE A 172
ZN  A 411 (-3.3A)
None
ZN  A 411 (-1.9A)
None
1.28A 1ismB-3ifeA:
undetectable
1ismB-3ifeA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3men ACETYLPOLYAMINE
AMINOHYDROLASE


(Burkholderia
pseudomallei)
PF00850
(Hist_deacetyl)
4 HIS A 156
LEU A 278
SER A 277
ASP A 190
SO4  A 401 (-3.6A)
None
None
K  A 402 (-3.0A)
1.04A 1ismB-3menA:
undetectable
1ismB-3menA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Yersinia pestis)
PF04095
(NAPRTase)
4 HIS A 221
LEU A 370
SER A 371
ASP A 259
None
0.87A 1ismB-3os4A:
undetectable
1ismB-3os4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis)
PF12741
(SusD-like)
4 TRP A 541
LEU A 164
SER A 163
ASP A 166
None
1.26A 1ismB-3p1uA:
undetectable
1ismB-3p1uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
4 LEU A 640
SER A 638
ASP A 636
PHE A 628
None
1.05A 1ismB-3p5pA:
undetectable
1ismB-3p5pA:
16.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5s CD38 MOLECULE

(Bos taurus)
PF02267
(Rib_hydrolayse)
4 TRP A 118
LEU A 137
ASP A 147
TRP A 181
AVU  A 280 (-3.8A)
AVU  A 280 (-3.7A)
AVU  A 280 (-3.9A)
AVU  A 280 (-3.6A)
0.35A 1ismB-3p5sA:
27.4
1ismB-3p5sA:
33.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE


(Mycoplana
ramosa)
PF00850
(Hist_deacetyl)
4 HIS A 158
LEU A 281
SER A 280
ASP A 193
Q9C  A 401 (-4.2A)
None
None
K  A 342 (-3.2A)
1.04A 1ismB-3q9cA:
undetectable
1ismB-3q9cA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rom ADP-RIBOSYL CYCLASE
1


(Homo sapiens)
PF02267
(Rib_hydrolayse)
4 TRP A 125
LEU A 145
ASP A 155
TRP A 189
48Z  A 301 (-3.6A)
48Z  A 301 ( 4.8A)
None
None
0.34A 1ismB-3romA:
28.4
1ismB-3romA:
34.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s38 CYTOCHROME C OXIDASE
SUBUNIT 2


(Thermus
thermophilus)
PF00116
(COX2)
PF09125
(COX2-transmemb)
4 HIS B 114
LEU B  84
SER B 109
ASP B 111
CUA  B 802 (-3.0A)
None
None
None
1.25A 1ismB-3s38B:
undetectable
1ismB-3s38B:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6b METHIONINE
AMINOPEPTIDASE


(Plasmodium
falciparum)
PF00557
(Peptidase_M24)
4 LEU A  68
SER A  69
ASP A 137
PHE A 162
None
1.12A 1ismB-3s6bA:
undetectable
1ismB-3s6bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slz GAG-PRO-POL
POLYPROTEIN


(Murine leukemia
virus)
PF00077
(RVP)
4 HIS A  80
LEU A  83
SER A  38
ASP A  96
FMT  A 127 (-3.4A)
None
None
None
1.10A 1ismB-3slzA:
undetectable
1ismB-3slzA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea)
PF00128
(Alpha-amylase)
PF09260
(DUF1966)
4 TRP A 367
SER A  46
ASP A  44
PHE A  40
None
1.20A 1ismB-3vm7A:
undetectable
1ismB-3vm7A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens)
PF00781
(DAGK_cat)
4 HIS A 156
LEU A 153
SER A 154
ASP A 235
None
1.29A 1ismB-3vzbA:
undetectable
1ismB-3vzbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
4 HIS A  66
LEU A  54
ASP A  13
TRP A 307
None
1.26A 1ismB-3wjoA:
undetectable
1ismB-3wjoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF00754
(F5_F8_type_C)
4 TRP A 356
LEU A 357
TRP A 258
PHE A 263
None
1.21A 1ismB-4ag4A:
undetectable
1ismB-4ag4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE


(Candida
albicans)
PF00069
(Pkinase)
4 LEU A 304
SER A 303
ASP A 319
PHE A 306
None
0.90A 1ismB-4c0tA:
undetectable
1ismB-4c0tA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es1 BH0342 PROTEIN

(Bacillus
halodurans)
PF09827
(CRISPR_Cas2)
4 LEU A  66
SER A  65
ASP A   8
PHE A  39
None
1.25A 1ismB-4es1A:
undetectable
1ismB-4es1A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN


(Schizosaccharomyces
pombe)
PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind)
4 HIS A1222
LEU A1062
SER A1024
ASP A1025
MN  A1501 (-3.6A)
None
None
MN  A1502 (-3.2A)
0.84A 1ismB-4fbqA:
undetectable
1ismB-4fbqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32


(Schizosaccharomyces
pombe)
no annotation 4 HIS B 222
LEU B  62
SER B  24
ASP B  25
MN  B 502 (-3.6A)
None
None
MN  B 501 (-3.3A)
0.72A 1ismB-4fcxB:
undetectable
1ismB-4fcxB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2c DYP2

(Amycolatopsis
sp. ATCC 39116)
no annotation 4 HIS A 323
LEU A 281
ASP A 414
PHE A 188
HEM  A 501 (-3.3A)
None
None
HEM  A 501 ( 4.8A)
1.07A 1ismB-4g2cA:
undetectable
1ismB-4g2cA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6b CITRATE SYNTHASE

(Escherichia
coli)
PF00285
(Citrate_synt)
4 HIS A 226
LEU A 369
SER A 365
ASP A 362
None
1.26A 1ismB-4g6bA:
undetectable
1ismB-4g6bA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis)
PF00266
(Aminotran_5)
4 HIS A 177
LEU A  74
SER A  71
ASP A  72
None
None
None
LLP  A 205 ( 4.6A)
1.12A 1ismB-4isyA:
undetectable
1ismB-4isyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
4 HIS A 749
LEU A 554
SER A 553
ASP A 549
ZN  A1102 (-3.4A)
None
None
ZN  A1102 (-2.8A)
1.21A 1ismB-4jx6A:
1.1
1ismB-4jx6A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 LEU A 582
SER A 581
ASP A 557
PHE A 563
None
0.81A 1ismB-4mnaA:
undetectable
1ismB-4mnaA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1


(Homo sapiens)
PF05994
(FragX_IP)
PF07159
(DUF1394)
4 TRP A 332
SER A 322
ASP A 275
PHE A 299
None
1.17A 1ismB-4n78A:
undetectable
1ismB-4n78A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE


(Homo sapiens)
PF00067
(p450)
4 LEU A 476
SER A 475
ASP A 487
TRP A 313
None
1.11A 1ismB-4nkyA:
undetectable
1ismB-4nkyA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2


(Mycobacterium
tuberculosis)
PF00557
(Peptidase_M24)
4 LEU A  12
SER A  13
ASP A  75
PHE A 100
None
1.01A 1ismB-4ookA:
undetectable
1ismB-4ookA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes)
no annotation 4 HIS H 741
LEU H 546
SER H 545
ASP H 541
None
1.21A 1ismB-4qslH:
undetectable
1ismB-4qslH:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC


(Homo sapiens)
PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1)
4 HIS B 237
SER B 387
ASP B 388
PHE B 337
None
1.04A 1ismB-4r3zB:
undetectable
1ismB-4r3zB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Sus scrofa)
PF00202
(Aminotran_3)
4 HIS A 190
LEU A 183
SER A 184
PHE A 295
None
1.07A 1ismB-4y0iA:
undetectable
1ismB-4y0iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yla AROMATIC
PRENYLTRANSFERASE


(Marinactinospora
thermotolerans)
PF11991
(Trp_DMAT)
4 HIS A 258
LEU A 299
ASP A 249
PHE A 285
None
1.13A 1ismB-4ylaA:
undetectable
1ismB-4ylaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1


(Homo sapiens)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
4 SER A 896
ASP A 899
TRP A 874
PHE A 937
None
1.27A 1ismB-4z7gA:
undetectable
1ismB-4z7gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ


(Escherichia
coli)
PF01055
(Glyco_hydro_31)
4 HIS A 196
LEU A 224
ASP A 198
PHE A 205
None
1.25A 1ismB-5aeeA:
undetectable
1ismB-5aeeA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5daj NALD

(Pseudomonas
aeruginosa)
PF00440
(TetR_N)
PF08361
(TetR_C_2)
4 LEU A  76
SER A  87
ASP A  90
PHE A 144
None
1.28A 1ismB-5dajA:
undetectable
1ismB-5dajA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE


(Thioalkalivibrio
paradoxus)
no annotation 4 HIS A 482
SER A 498
ASP A 480
PHE A 104
None
1.28A 1ismB-5f75A:
undetectable
1ismB-5f75A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1o CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS2


(Xanthomonas
albilineans)
no annotation 4 LEU A  66
SER A  65
ASP A   8
PHE A  39
None
None
ACT  A 201 (-3.7A)
None
1.26A 1ismB-5h1oA:
undetectable
1ismB-5h1oA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2)
PF01425
(Amidase)
4 LEU A 389
SER A 149
ASP A 147
PHE A 391
None
1.10A 1ismB-5h6sA:
undetectable
1ismB-5h6sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT


(Pyrococcus
abyssi)
PF00149
(Metallophos)
4 HIS A 497
SER A 359
ASP A 360
PHE A 463
ZN  A 703 ( 3.5A)
None
FE  A 702 ( 3.0A)
None
1.27A 1ismB-5iheA:
undetectable
1ismB-5iheA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE


(Thermotoga
maritima)
PF00496
(SBP_bac_5)
4 HIS A 219
LEU A 262
ASP A 149
PHE A 224
None
1.22A 1ismB-5ipwA:
undetectable
1ismB-5ipwA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Geoglobus
acetivorans)
PF00348
(polyprenyl_synt)
4 LEU A 233
SER A 230
ASP A 217
PHE A 254
None
1.15A 1ismB-5jfqA:
undetectable
1ismB-5jfqA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE


(Mycobacterium
tuberculosis)
PF01565
(FAD_binding_4)
PF02873
(MurB_C)
4 LEU A 124
SER A 125
ASP A 107
PHE A 197
None
0.98A 1ismB-5jzxA:
undetectable
1ismB-5jzxA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA


(Methylobacillus
flagellatus)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
4 HIS C 205
LEU C  18
SER C  17
ASP C  13
MN  C2002 (-3.6A)
None
None
MN  C2002 (-2.4A)
1.20A 1ismB-5ks8C:
undetectable
1ismB-5ks8C:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG


(Homo sapiens)
PF04821
(TIMELESS)
4 TRP A 191
HIS A 194
LEU A 190
ASP A 199
SO4  A1602 ( 4.1A)
None
None
None
1.22A 1ismB-5mqiA:
undetectable
1ismB-5mqiA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkz PEROXIN 22

(Ogataea angusta)
no annotation 4 LEU D  91
SER D  88
ASP D  86
PHE D  94
None
1.11A 1ismB-5nkzD:
undetectable
1ismB-5nkzD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN


(Burkholderia
thailandensis)
no annotation 4 LEU A  60
SER A  57
ASP A  80
PHE A 163
None
None
SAH  A 301 (-4.0A)
None
1.19A 1ismB-5ufmA:
undetectable
1ismB-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6p ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE HRD1


(Saccharomyces
cerevisiae)
no annotation 4 LEU A 185
SER A 182
ASP A 179
PHE A 111
None
1.27A 1ismB-5v6pA:
undetectable
1ismB-5v6pA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis)
PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 HIS A 734
LEU A 539
SER A 538
ASP A 534
MN  A1201 (-4.0A)
None
None
MN  A1201 (-2.8A)
1.23A 1ismB-5vywA:
undetectable
1ismB-5vywA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqs BETA-AMYLASE

(Ipomoea batatas)
no annotation 4 HIS A 275
LEU A 136
ASP A 141
PHE A  93
None
1.09A 1ismB-5wqsA:
undetectable
1ismB-5wqsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata)
no annotation 4 HIS A 298
LEU A 124
SER A 125
ASP A 263
None
1.23A 1ismB-5xmdA:
undetectable
1ismB-5xmdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT


(Plasmodium
falciparum)
PF00069
(Pkinase)
4 HIS A 313
LEU A 217
SER A 216
ASP A 214
None
1.24A 1ismB-5xvuA:
undetectable
1ismB-5xvuA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0x MAD2L1-BINDING
PROTEIN


(Homo sapiens)
no annotation 4 LEU P 172
SER P 170
ASP P 168
PHE P  60
None
1.18A 1ismB-6f0xP:
undetectable
1ismB-6f0xP:
undetectable