SIMILAR PATTERNS OF AMINO ACIDS FOR 1ILQ_C_ACAC7_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Toxoplasma
gondii) 		PF00156
(Pribosyltran) 		4 HIS A 216
PHE A 214
ASP A  30
PRO A  35
 None
 1.25A 1ilqA-1dbrA:
0.0
1ilqC-1dbrA:
undetectable		 1ilqA-1dbrA:
14.93
1ilqC-1dbrA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lhu SEX HORMONE-BINDING
GLOBULIN

(Homo sapiens) 		PF00054
(Laminin_G_1) 		4 HIS A 101
ASP A  96
ASP A  50
PRO A  76
 None
None
CA  A 401 (-2.1A)
None
 1.39A 1ilqA-1lhuA:
undetectable
1ilqC-1lhuA:
undetectable		 1ilqA-1lhuA:
18.54
1ilqC-1lhuA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 HIS A 259
ASP A 262
ASP A 287
PRO A 119
 None
None
CD  A 562 ( 2.8A)
None
 1.07A 1ilqA-1lxtA:
0.0
1ilqC-1lxtA:
undetectable		 1ilqA-1lxtA:
10.23
1ilqC-1lxtA:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aquifex
aeolicus) 		PF01791
(DeoC) 		4 HIS A 317
PHE A 313
ASP A 103
MET A 101
 None
 0.92A 1ilqA-1mzhA:
0.1
1ilqC-1mzhA:
undetectable		 1ilqA-1mzhA:
17.22
1ilqC-1mzhA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 HIS A 365
ASP A 364
ASP A 362
PRO A 368
 None
 0.83A 1ilqA-1szsA:
0.0
1ilqC-1szsA:
undetectable		 1ilqA-1szsA:
9.62
1ilqC-1szsA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq9 PHOSPHOGLYCERATE
MUTASE

(Plasmodium
falciparum) 		PF00300
(His_Phos_1) 		4 HIS A 144
ASP A 138
ASP A 135
PRO A 142
 None
 1.39A 1ilqA-1xq9A:
0.0
1ilqC-1xq9A:
undetectable		 1ilqA-1xq9A:
14.51
1ilqC-1xq9A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		4 HIS A 524
PHE A  42
ASP A 521
PRO A 115
 None
 1.31A 1ilqA-1yt8A:
0.0
1ilqC-1yt8A:
undetectable		 1ilqA-1yt8A:
9.28
1ilqC-1yt8A:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		4 ASP A 143
ASP A 123
MET A 145
PRO A 146
 None
 1.47A 1ilqA-2a5hA:
0.0
1ilqC-2a5hA:
undetectable		 1ilqA-2a5hA:
10.89
1ilqC-2a5hA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 4 HIS A 241
ASP A 156
ASP A 160
PRO A 111
 None
 1.31A 1ilqA-2cl2A:
0.0
1ilqC-2cl2A:
undetectable		 1ilqA-2cl2A:
11.70
1ilqC-2cl2A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlg FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		4 HIS A  57
ASP A  20
MET A  52
PRO A  51
 None
 1.43A 1ilqA-2dlgA:
undetectable
1ilqC-2dlgA:
undetectable		 1ilqA-2dlgA:
23.00
1ilqC-2dlgA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 PHE A 572
ASP A 579
ASP A 578
PRO A 581
 None
 1.15A 1ilqA-2iuuA:
undetectable
1ilqC-2iuuA:
undetectable		 1ilqA-2iuuA:
10.32
1ilqC-2iuuA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j66 BTRK

(Bacillus
circulans) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 HIS A 383
ASP A 411
ASP A 410
PRO A 388
 None
 1.32A 1ilqA-2j66A:
undetectable
1ilqC-2j66A:
undetectable		 1ilqA-2j66A:
12.46
1ilqC-2j66A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j89 METHIONINE SULFOXIDE
REDUCTASE A

(Populus
trichocarpa) 		PF01625
(PMSR) 		4 PHE A  39
ASP A  29
ASP A  30
PRO A  33
 None
 1.39A 1ilqA-2j89A:
undetectable
1ilqC-2j89A:
undetectable		 1ilqA-2j89A:
15.20
1ilqC-2j89A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mq1 E3 UBIQUITIN-PROTEIN
LIGASE HAKAI

(Mus musculus) 		no annotation 4 HIS A  22
PHE A  24
ASP A   5
PRO A  41
 ZN  A 102 (-2.8A)
None
None
None
 1.01A 1ilqA-2mq1A:
undetectable
1ilqC-2mq1A:
undetectable		 1ilqA-2mq1A:
22.35
1ilqC-2mq1A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pft EXOCYTOSIS PROTEIN

(Mus musculus) 		PF03081
(Exo70) 		4 HIS A 342
PHE A 344
ASP A 396
ASP A 399
 None
 1.11A 1ilqA-2pftA:
undetectable
1ilqC-2pftA:
undetectable		 1ilqA-2pftA:
10.38
1ilqC-2pftA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzx G-PROTEIN COUPLED
RECEPTOR MTH

(Drosophila
melanogaster) 		PF06652
(Methuselah_N) 		4 PHE A   8
ASP A  47
ASP A  46
PRO A 123
 None
 1.33A 1ilqA-2pzxA:
undetectable
1ilqC-2pzxA:
undetectable		 1ilqA-2pzxA:
19.51
1ilqC-2pzxA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 HIS A 596
PHE A 721
ASP A 723
PRO A 588
 None
 1.46A 1ilqA-2wl1A:
undetectable
1ilqC-2wl1A:
undetectable		 1ilqA-2wl1A:
19.75
1ilqC-2wl1A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grc SENSOR PROTEIN,
KINASE

(Polaromonas sp.
JS666) 		PF00072
(Response_reg) 		4 HIS A 578
ASP A 555
ASP A 598
PRO A 557
 None
 1.14A 1ilqA-3grcA:
undetectable
1ilqC-3grcA:
undetectable		 1ilqA-3grcA:
18.52
1ilqC-3grcA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'

(Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 HIS A  89
PHE A  93
ASP A 198
PRO A 204
 None
 0.73A 1ilqA-3hkzA:
undetectable
1ilqC-3hkzA:
undetectable		 1ilqA-3hkzA:
6.21
1ilqC-3hkzA:
1.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		4 HIS A 360
PHE A 366
ASP A 322
PRO A 329
 None
 1.36A 1ilqA-3jz4A:
undetectable
1ilqC-3jz4A:
undetectable		 1ilqA-3jz4A:
10.22
1ilqC-3jz4A:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m SENSORY/REGULATORY
PROTEIN RPFC

(Xanthomonas
campestris) 		PF00072
(Response_reg) 		4 HIS D 514
ASP D 468
MET D 515
PRO D 516
 None
MG  D 591 ( 4.4A)
None
None
 1.29A 1ilqA-3m6mD:
undetectable
1ilqC-3m6mD:
undetectable		 1ilqA-3m6mD:
19.26
1ilqC-3m6mD:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me8 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF02630
(SCO1-SenC) 		4 HIS A 126
PHE A 115
ASP A  73
PRO A  35
 None
 1.49A 1ilqA-3me8A:
undetectable
1ilqC-3me8A:
undetectable		 1ilqA-3me8A:
18.90
1ilqC-3me8A:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		4 HIS A 283
ASP A 199
ASP A 202
PRO A 197
 None
 1.28A 1ilqA-3nwoA:
undetectable
1ilqC-3nwoA:
undetectable		 1ilqA-3nwoA:
10.67
1ilqC-3nwoA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		4 HIS A 211
ASP A 209
ASP A 208
PRO A 214
 None
 1.46A 1ilqA-3nwpA:
undetectable
1ilqC-3nwpA:
undetectable		 1ilqA-3nwpA:
13.76
1ilqC-3nwpA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 HIS A 544
ASP A 633
ASP A 631
PRO A 547
 None
 1.48A 1ilqA-3poyA:
undetectable
1ilqC-3poyA:
undetectable		 1ilqA-3poyA:
5.68
1ilqC-3poyA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 HIS A 345
ASP A 139
ASP A 140
PRO A 347
 None
 1.25A 1ilqA-3syjA:
undetectable
1ilqC-3syjA:
undetectable		 1ilqA-3syjA:
4.85
1ilqC-3syjA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ztg E3 UBIQUITIN-PROTEIN
LIGASE RBBP6

(Homo sapiens) 		PF04564
(U-box) 		4 PHE A 322
ASP A 251
ASP A 250
PRO A 254
 None
 1.43A 1ilqA-3ztgA:
undetectable
1ilqC-3ztgA:
undetectable		 1ilqA-3ztgA:
20.21
1ilqC-3ztgA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0s DEAMIDASE-DEPUPYLASE
DOP

(Acidothermus
cellulolyticus) 		PF03136
(Pup_ligase) 		4 HIS A 172
ASP A 276
ASP A 303
PRO A 175
 None
 1.38A 1ilqA-4b0sA:
undetectable
1ilqC-4b0sA:
undetectable		 1ilqA-4b0sA:
8.62
1ilqC-4b0sA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg4 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 HIS A 596
PHE A 721
ASP A 723
PRO A 588
 None
 1.46A 1ilqA-4cg4A:
undetectable
1ilqC-4cg4A:
undetectable		 1ilqA-4cg4A:
13.13
1ilqC-4cg4A:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 HIS A 117
PHE A 119
ASP A  88
ASP A  89
 None
 1.21A 1ilqA-4di5A:
undetectable
1ilqC-4di5A:
undetectable		 1ilqA-4di5A:
10.17
1ilqC-4di5A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		4 HIS A 318
ASP A 322
ASP A 321
PRO A 314
 ZN  A 401 ( 3.2A)
None
None
None
 1.49A 1ilqA-4faiA:
undetectable
1ilqC-4faiA:
undetectable		 1ilqA-4faiA:
11.62
1ilqC-4faiA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6v AMIDOHYDROLASE 2

(Planctopirus
limnophila) 		PF02614
(UxaC) 		4 HIS A 204
ASP A 148
ASP A 145
PRO A 160
 None
 1.34A 1ilqA-4i6vA:
undetectable
1ilqC-4i6vA:
undetectable		 1ilqA-4i6vA:
9.51
1ilqC-4i6vA:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		4 HIS A 322
ASP A 326
ASP A 325
PRO A 318
 None
 1.48A 1ilqA-4mhpA:
undetectable
1ilqC-4mhpA:
undetectable		 1ilqA-4mhpA:
11.84
1ilqC-4mhpA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 HIS A 290
PHE A 257
ASP A 396
ASP A 397
 None
 1.13A 1ilqA-4o6rA:
undetectable
1ilqC-4o6rA:
undetectable		 1ilqA-4o6rA:
9.91
1ilqC-4o6rA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht TYPE II SECRETION
SYSTEM PROTEIN L

(Vibrio
vulnificus) 		PF05134
(T2SSL) 		4 PHE X 193
ASP X 145
ASP X 146
PRO X 143
 None
 1.05A 1ilqA-4phtX:
undetectable
1ilqC-4phtX:
undetectable		 1ilqA-4phtX:
14.05
1ilqC-4phtX:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpv PLATELET INHIBITOR

(Ancylostoma
caninum) 		PF00188
(CAP) 		4 HIS A  25
PHE A  21
ASP A  73
PRO A  83
 None
 1.32A 1ilqA-4tpvA:
undetectable
1ilqC-4tpvA:
undetectable		 1ilqA-4tpvA:
15.92
1ilqC-4tpvA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C)
PF14630
(ORC5_C) 		4 HIS E 179
PHE E  40
ASP D 335
ASP D 334
 None
 1.42A 1ilqA-4xgcE:
undetectable
1ilqC-4xgcE:
undetectable		 1ilqA-4xgcE:
10.61
1ilqC-4xgcE:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS

(Bacillus
subtilis) 		PF00067
(p450) 		4 HIS A  99
ASP A  95
ASP A  65
PRO A  97
 HIS  A  99 (-1.0A)
ASP  A  95 ( 0.6A)
ASP  A  65 ( 0.6A)
PRO  A  97 ( 1.0A)
 1.49A 1ilqA-4yzrA:
undetectable
1ilqC-4yzrA:
undetectable		 1ilqA-4yzrA:
13.02
1ilqC-4yzrA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahv ANTH DOMAIN OF
ENDOCYTIC ADAPTOR
SLA2

(Saccharomyces
cerevisiae) 		PF07651
(ANTH) 		4 HIS F 232
ASP F 260
ASP F 263
PRO F 258
 None
 1.49A 1ilqA-5ahvF:
undetectable
1ilqC-5ahvF:
undetectable		 1ilqA-5ahvF:
14.61
1ilqC-5ahvF:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		4 HIS A  84
ASP A 115
ASP A 116
PRO A 113
 None
 1.20A 1ilqA-5axhA:
undetectable
1ilqC-5axhA:
undetectable		 1ilqA-5axhA:
7.16
1ilqC-5axhA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 PHE A 225
ASP A 217
ASP A 218
PRO A 215
 None
 1.50A 1ilqA-5brqA:
undetectable
1ilqC-5brqA:
undetectable		 1ilqA-5brqA:
8.10
1ilqC-5brqA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 HIS A 251
PHE A 234
ASP A 230
PRO A 287
 None
 1.17A 1ilqA-5dl7A:
undetectable
1ilqC-5dl7A:
undetectable		 1ilqA-5dl7A:
11.32
1ilqC-5dl7A:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 HIS A 803
ASP A 929
ASP A 928
PRO A 807
 None
 1.36A 1ilqA-5hy7A:
undetectable
1ilqC-5hy7A:
undetectable		 1ilqA-5hy7A:
5.60
1ilqC-5hy7A:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 276
ASP A 269
MET A 273
PRO A 274
 None
 1.41A 1ilqA-5idnA:
undetectable
1ilqC-5idnA:
undetectable		 1ilqA-5idnA:
13.48
1ilqC-5idnA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imy VAGINOLYSIN

(Gardnerella
vaginalis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 ASP A 129
ASP A 213
MET A 131
PRO A 132
 None
 1.40A 1ilqA-5imyA:
undetectable
1ilqC-5imyA:
undetectable		 1ilqA-5imyA:
9.59
1ilqC-5imyA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm2 CAPSID PROTEIN VP4B

(Nora virus) 		no annotation 4 HIS B  20
ASP B  19
ASP B 213
PRO B  24
 None
 1.34A 1ilqA-5mm2B:
undetectable
1ilqC-5mm2B:
undetectable		 1ilqA-5mm2B:
15.07
1ilqC-5mm2B:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830

(Geobacillus
stearothermophilus) 		PF06778
(Chlor_dismutase) 		4 PHE A 195
ASP A 147
MET A 146
PRO A 145
 None
None
76R  A 301 ( 2.9A)
None
 1.40A 1ilqA-5t2kA:
undetectable
1ilqC-5t2kA:
undetectable		 1ilqA-5t2kA:
16.74
1ilqC-5t2kA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y81 ACTIN-RELATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		no annotation 4 HIS F 192
PHE F 189
ASP F 299
ASP F 298
 None
 1.05A 1ilqA-5y81F:
undetectable
1ilqC-5y81F:
undetectable		 1ilqA-5y81F:
20.29
1ilqC-5y81F:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E

(Pseudomonas sp.
AIU 813) 		no annotation 4 HIS A 453
ASP A 377
ASP A 385
PRO A 373
 None
 1.29A 1ilqA-5yb7A:
undetectable
1ilqC-5yb7A:
undetectable		 1ilqA-5yb7A:
16.46
1ilqC-5yb7A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 4 HIS A 183
ASP A 178
ASP A 175
MET A 179
 None
 1.00A 1ilqA-5zb8A:
undetectable
1ilqC-5zb8A:
undetectable		 1ilqA-5zb8A:
16.25
1ilqC-5zb8A:
11.86