SIMILAR PATTERNS OF AMINO ACIDS FOR 1ILP_C_ACAC7

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m72 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		4 PRO A  45
HIS A  57
ASP A 127
MET A  55
 None
 1.35A 1ilpA-1m72A:
0.0
1ilpC-1m72A:
undetectable		 1ilpA-1m72A:
13.72
1ilpC-1m72A:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4z BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 LYS A 228
PRO A 227
HIS A 215
ASP A 224
 None
 1.49A 1ilpA-1o4zA:
0.0
1ilpC-1o4zA:
undetectable		 1ilpA-1o4zA:
11.90
1ilpC-1o4zA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayb DNA-DIRECTED RNA
POLYMERASE

(Sulfolobus
shibatae) 		PF01194
(RNA_pol_N) 		4 PRO N   4
HIS N  52
ASP N  54
MET N   2
 None
 1.40A 1ilpA-4aybN:
undetectable
1ilpC-4aybN:
undetectable		 1ilpA-4aybN:
17.14
1ilpC-4aybN:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q60 PROLINE RACEMASE

(Burkholderia
multivorans) 		PF05544
(Pro_racemase) 		4 LYS A 234
PRO A 236
HIS A 209
ASP A 208
 None
 1.42A 1ilpA-4q60A:
0.3
1ilpC-4q60A:
undetectable		 1ilpA-4q60A:
11.73
1ilpC-4q60A:
3.69