SIMILAR PATTERNS OF AMINO ACIDS FOR 1IIU_A_RTLA176

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		5 LEU A 139
LEU A  56
ALA A  48
ALA A  60
LEU A  23
 None
 1.39A 1iiuA-1bg6A:
undetectable		 1iiuA-1bg6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 ALA A 309
ALA A 302
LEU A 405
GLN A 409
ARG A 334
 None
 1.36A 1iiuA-1d6mA:
0.5		 1iiuA-1d6mA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		5 LEU B  98
ALA B  90
MET B   8
MET B  23
LEU B  29
 None
 1.26A 1iiuA-1ep2B:
0.0		 1iiuA-1ep2B:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 307
ALA A 315
MET A 272
MET A 286
LEU A 268
 961  A 450 (-4.8A)
None
961  A 450 (-3.1A)
None
961  A 450 ( 4.9A)
 1.27A 1iiuA-1exxA:
0.0		 1iiuA-1exxA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		5 ALA A 561
ALA A 558
TYR A 648
LEU A 543
GLN A 548
 None
 1.23A 1iiuA-1gxnA:
0.0		 1iiuA-1gxnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hz4 MALT REGULATORY
PROTEIN

(Escherichia
coli) 		no annotation 5 LEU A 290
LEU A 277
ALA A 260
ALA A 258
LEU A 297
 None
 1.21A 1iiuA-1hz4A:
undetectable		 1iiuA-1hz4A:
17.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		11 LEU A  35
LEU A  37
ALA A  55
ALA A  57
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
ARG A 121
 RTL  A 176 (-4.5A)
RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.7A)
RTL  A 176 ( 4.8A)
 0.01A 1iiuA-1iiuA:
35.1		 1iiuA-1iiuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		5 LEU A  37
ALA A  57
MET A  73
LEU A  97
HIS A 117
 RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 ( 4.6A)
 1.26A 1iiuA-1iiuA:
35.1		 1iiuA-1iiuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 LEU A  49
ALA A 204
ALA A 202
HIS A 125
ARG A 138
 None
 1.34A 1iiuA-1js4A:
0.1		 1iiuA-1js4A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2f KAIA

(Synechococcus
elongatus) 		no annotation 5 ALA A 123
ALA A 121
TYR A 116
LEU A 114
GLN A 113
 None
 1.25A 1iiuA-1m2fA:
undetectable		 1iiuA-1m2fA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m68 HYPOTHETICAL PROTEIN
YCDX

(Escherichia
coli) 		PF02811
(PHP) 		5 LEU A 228
LEU A 220
ALA A 148
ALA A 154
LEU A  95
 None
 1.16A 1iiuA-1m68A:
0.0		 1iiuA-1m68A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE

(Pseudomonas sp.
P51) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 270
LEU A 268
ALA A 258
ALA A 286
LEU A 280
 None
 1.24A 1iiuA-1nu5A:
undetectable		 1iiuA-1nu5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE

(Pseudomonas sp.
P51) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 270
LEU A 268
ALA A 289
ALA A 286
LEU A 280
 None
 1.29A 1iiuA-1nu5A:
undetectable		 1iiuA-1nu5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Bacillus
subtilis) 		PF01070
(FMN_dh) 		5 LEU A  98
ALA A 141
ALA A 135
MET A 138
TYR A 107
 None
 1.41A 1iiuA-1p0nA:
undetectable		 1iiuA-1p0nA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		5 LEU A 258
LEU A 256
ALA A 289
ALA A 287
GLN A 263
 None
 1.34A 1iiuA-1p9eA:
undetectable		 1iiuA-1p9eA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 LEU A  59
ALA A 202
ALA A 387
TYR A 395
LEU A 399
 None
 1.19A 1iiuA-1z6rA:
undetectable		 1iiuA-1z6rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 744
ALA A 721
ALA A 719
LEU A 712
GLN A 711
 None
None
None
None
BHM  A   1 (-2.2A)
 1.12A 1iiuA-2ax9A:
undetectable		 1iiuA-2ax9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 308
ALA A 338
ALA A 342
GLN A 320
ARG A 394
 None
 1.42A 1iiuA-2db3A:
undetectable		 1iiuA-2db3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 358
ALA A 265
ALA A 263
LEU A 256
ARG A 353
 None
 1.25A 1iiuA-2ebaA:
undetectable		 1iiuA-2ebaA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 LEU A 306
ALA A 367
ALA A 360
MET A 359
HIS A 322
 None
 1.41A 1iiuA-2erqA:
undetectable		 1iiuA-2erqA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ALA A 240
MET A 281
TYR A 278
LEU A 285
ARG A 304
 None
 1.31A 1iiuA-2f43A:
undetectable		 1iiuA-2f43A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe8 REPLICASE
POLYPROTEIN 1AB

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		5 LEU A 153
LEU A 151
ALA A 130
LEU A 173
ARG A  83
 None
None
SO4  A 320 ( 4.1A)
None
None
 1.25A 1iiuA-2fe8A:
undetectable		 1iiuA-2fe8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 LEU A  62
LEU A  60
ALA A  50
ALA A  48
LEU A  41
 None
 1.25A 1iiuA-2g37A:
undetectable		 1iiuA-2g37A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		5 LEU A 367
LEU A 155
ALA A 225
ALA A 227
LEU A 234
 None
 1.33A 1iiuA-2g85A:
undetectable		 1iiuA-2g85A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gi7 GPVI PROTEIN

(Homo sapiens) 		PF13895
(Ig_2) 		5 LEU A  42
LEU A  83
ALA A  12
MET A  58
LEU A  39
 SO4  A 203 ( 4.9A)
None
None
None
SO4  A 204 (-4.9A)
 1.35A 1iiuA-2gi7A:
undetectable		 1iiuA-2gi7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 LEU A  95
LEU A 573
ALA A  67
MET A  61
LEU A  57
 None
 1.29A 1iiuA-2h4tA:
undetectable		 1iiuA-2h4tA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbb TALIN-1

(Mus musculus) 		no annotation 5 LEU A1796
LEU A1776
ALA A1735
MET A1734
LEU A1716
 None
 1.36A 1iiuA-2kbbA:
undetectable		 1iiuA-2kbbA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC

(Escherichia
coli) 		PF04381
(RdgC) 		5 LEU A  12
ALA A  20
MET A  23
LEU A 158
HIS A  58
 None
 1.35A 1iiuA-2owlA:
undetectable		 1iiuA-2owlA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 408
ALA A 354
MET A 344
GLN A 340
ARG A 415
 None
 1.35A 1iiuA-2p8uA:
undetectable		 1iiuA-2p8uA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		5 LEU A 112
ALA A 190
ALA A 121
MET A 120
LEU A 244
 None
None
None
ACY  A 500 ( 4.4A)
None
 1.32A 1iiuA-2qc3A:
undetectable		 1iiuA-2qc3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qop HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ACRR

(Escherichia
coli) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		5 LEU A  86
LEU A 145
ALA A 164
MET A 167
LEU A 198
 None
 1.19A 1iiuA-2qopA:
undetectable		 1iiuA-2qopA:
18.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  37
ALA A  55
ALA A  57
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
ARG A 121
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
 0.52A 1iiuA-2wq9A:
30.5		 1iiuA-2wq9A:
86.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		5 LEU A 271
LEU A 266
ALA A  95
ALA A 289
LEU A 321
 None
 1.41A 1iiuA-2wu0A:
undetectable		 1iiuA-2wu0A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x27 OUTER MEMBRANE
PROTEIN OPRG

(Pseudomonas
aeruginosa) 		PF03922
(OmpW) 		5 ALA X  57
TYR X 102
LEU X  99
GLN X 100
ARG X  13
 None
None
C8E  X1217 (-3.8A)
None
None
 1.28A 1iiuA-2x27X:
3.4		 1iiuA-2x27X:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 5 LEU A 312
LEU A 319
ALA A 232
MET A 219
TYR A 221
 None
 1.40A 1iiuA-2zuxA:
undetectable		 1iiuA-2zuxA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bch 40S RIBOSOMAL
PROTEIN SA

(Homo sapiens) 		PF00318
(Ribosomal_S2)
PF16122
(40S_SA_C) 		5 LEU A  58
LEU A 173
ALA A  20
LEU A  51
ARG A 180
 None
 1.25A 1iiuA-3bchA:
undetectable		 1iiuA-3bchA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 315
ALA A 284
ALA A 280
TYR A 278
ARG A 318
 None
 1.30A 1iiuA-3cgdA:
undetectable		 1iiuA-3cgdA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		5 LEU A 272
LEU A 105
ALA A  96
ALA A  98
LEU A 129
 None
 1.31A 1iiuA-3czeA:
undetectable		 1iiuA-3czeA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dt8 BRAIN
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
SUBUNIT ALPHA

(Bos taurus) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 194
LEU A 139
ALA A 207
ALA A 174
TYR A 201
 SGB  A  47 ( 4.6A)
None
None
None
None
 1.40A 1iiuA-3dt8A:
undetectable		 1iiuA-3dt8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 226
ALA A 191
MET A  61
LEU A 235
HIS A  60
 None
 1.27A 1iiuA-3e7wA:
undetectable		 1iiuA-3e7wA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 303
ALA A  56
MET A  60
MET A  76
LEU A 333
 None
 1.40A 1iiuA-3fgqA:
undetectable		 1iiuA-3fgqA:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  35
ALA A  55
ALA A  57
MET A  73
GLN A  98
 2T1  A 184 (-4.0A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.0A)
 1.16A 1iiuA-3fmzA:
29.8		 1iiuA-3fmzA:
73.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		7 LEU A  35
ALA A  55
ALA A  57
MET A  88
TYR A  90
GLN A  98
HIS A 104
 2T1  A 184 (-4.0A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
 0.89A 1iiuA-3fmzA:
29.8		 1iiuA-3fmzA:
73.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  35
LEU A  37
ALA A  55
ALA A  57
MET A  73
ARG A 121
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.2A)
 0.92A 1iiuA-3fmzA:
29.8		 1iiuA-3fmzA:
73.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  35
LEU A  37
ALA A  55
ALA A  57
MET A  88
TYR A  90
HIS A 104
ARG A 121
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.7A)
2T1  A 184 (-3.2A)
 0.66A 1iiuA-3fmzA:
29.8		 1iiuA-3fmzA:
73.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqj CELL INHIBITING
FACTOR (CIF)

(Photorhabdus
laumondii) 		PF16374
(CIF) 		5 LEU A 249
LEU A 254
ALA A 127
LEU A 230
ARG A 178
 None
 1.39A 1iiuA-3gqjA:
undetectable		 1iiuA-3gqjA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvz UNCHARACTERIZED
PROTEIN CV2077

(Chromobacterium
violaceum) 		PF03417
(AAT) 		5 LEU A 212
ALA A 259
ALA A 240
LEU A 254
GLN A 255
 None
 1.28A 1iiuA-3gvzA:
undetectable		 1iiuA-3gvzA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2s PUTATIVE NADH-FLAVIN
REDUCTASE

(Lactobacillus
paracasei) 		PF13460
(NAD_binding_10) 		5 LEU A  53
LEU A  55
ALA A  65
ALA A   4
LEU A  70
 None
None
None
None
NDP  A 301 (-4.4A)
 1.22A 1iiuA-3h2sA:
undetectable		 1iiuA-3h2sA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 218
ALA A 214
ALA A 216
TYR A 264
LEU A 266
 None
 1.34A 1iiuA-3ifeA:
undetectable		 1iiuA-3ifeA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 LEU A 271
ALA A 467
LEU A 667
GLN A 666
ARG A 440
 None
 1.30A 1iiuA-3j04A:
undetectable		 1iiuA-3j04A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU E 287
LEU E 415
ALA E 300
ALA E 298
LEU E 291
 None
 1.38A 1iiuA-3kfuE:
undetectable		 1iiuA-3kfuE:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 758
ALA A 743
ALA A 739
LEU A 723
GLN A 763
 None
 1.06A 1iiuA-3lzbA:
undetectable		 1iiuA-3lzbA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		5 LEU A 233
LEU A 237
ALA A 315
LEU A 310
GLN A 311
 None
 1.35A 1iiuA-3o82A:
undetectable		 1iiuA-3o82A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME

(Vibrio cholerae) 		PF01965
(DJ-1_PfpI) 		5 LEU B 179
LEU B  29
ALA B 106
ALA B  73
LEU B 174
 None
 1.30A 1iiuA-3ot1B:
undetectable		 1iiuA-3ot1B:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 394
ALA A 301
ALA A 297
MET A 296
LEU A 275
 None
 1.13A 1iiuA-3q4tA:
undetectable		 1iiuA-3q4tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  31
LEU A  94
ALA A 185
TYR A 208
LEU A 244
 None
 1.08A 1iiuA-3rg2A:
undetectable		 1iiuA-3rg2A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 LEU A  41
ALA A 197
ALA A  53
LEU A 116
ARG A 216
 None
 1.38A 1iiuA-3swxA:
undetectable		 1iiuA-3swxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU A 220
ALA A 236
ALA A 232
MET A 231
LEU A 186
 LEU  A 220 ( 0.5A)
ALA  A 236 ( 0.0A)
ALA  A 232 ( 0.0A)
MET  A 231 ( 0.0A)
LEU  A 186 (-0.6A)
 1.11A 1iiuA-3whlA:
undetectable		 1iiuA-3whlA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		5 LEU A  77
LEU A 142
ALA A 161
ALA A 157
LEU A  84
 None
 1.36A 1iiuA-3wx7A:
undetectable		 1iiuA-3wx7A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		5 ALA A 109
ALA A 149
MET A 414
GLN A  52
HIS A 411
 None
 1.35A 1iiuA-3wxoA:
undetectable		 1iiuA-3wxoA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 ALA A 105
MET A 100
LEU A 135
GLN A 148
HIS A  89
 None
 1.35A 1iiuA-3zkbA:
undetectable		 1iiuA-3zkbA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		5 LEU A 294
ALA A 197
ALA A 256
MET A 253
LEU A 225
 None
 1.11A 1iiuA-4b3kA:
undetectable		 1iiuA-4b3kA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 LEU A 127
ALA A 118
ALA A 130
LEU A 236
HIS A 100
 None
None
None
None
SO4  A1823 (-3.9A)
 1.30A 1iiuA-4b9yA:
undetectable		 1iiuA-4b9yA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 LEU A 485
ALA A 391
MET A 450
LEU A 446
ARG A 464
 None
 1.21A 1iiuA-4btpA:
undetectable		 1iiuA-4btpA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		5 LEU A 116
ALA A 119
MET A 120
LEU A 148
GLN A 150
 None
 1.36A 1iiuA-4e69A:
undetectable		 1iiuA-4e69A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcy TRANSPOSASE

(Escherichia
virus Mu) 		PF02316
(HTH_Tnp_Mu_1)
PF02914
(DDE_2)
PF09039
(HTH_Tnp_Mu_2)
PF09299
(Mu-transpos_C) 		5 LEU A 193
LEU A 188
ALA A 222
ALA A 224
LEU A 231
 None
 1.36A 1iiuA-4fcyA:
undetectable		 1iiuA-4fcyA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 LEU A 337
ALA A 318
ALA A 163
TYR A 330
GLN A 334
 None
 1.02A 1iiuA-4g6cA:
undetectable		 1iiuA-4g6cA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 317
ALA A 294
ALA A 290
GLN A 333
HIS A 326
 None
 1.37A 1iiuA-4hnlA:
undetectable		 1iiuA-4hnlA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A  43
ALA A  47
MET A 338
TYR A 341
LEU A  62
 None
 1.31A 1iiuA-4iigA:
undetectable		 1iiuA-4iigA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		5 LEU A 206
LEU A 211
ALA A 309
LEU A 251
ARG A 519
 None
 1.33A 1iiuA-4kf7A:
undetectable		 1iiuA-4kf7A:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU A 497
ALA A 520
MET A 515
TYR A 475
LEU A 468
 None
 1.25A 1iiuA-4knhA:
undetectable		 1iiuA-4knhA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		5 LEU B 400
LEU B 345
ALA B 315
GLN B 380
HIS B 370
 None
 1.36A 1iiuA-4mbgB:
undetectable		 1iiuA-4mbgB:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN

(Aeropyrum
pernix) 		PF02608
(Bmp) 		5 LEU A 323
LEU A 358
ALA A 196
TYR A 277
GLN A 306
 None
 1.23A 1iiuA-4pevA:
undetectable		 1iiuA-4pevA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		5 LEU A 505
ALA A 184
ALA A 418
MET A 419
LEU A 490
 None
 1.33A 1iiuA-4pxqA:
undetectable		 1iiuA-4pxqA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 223
ALA A 169
MET A 220
LEU A 206
ARG A 303
 None
 1.23A 1iiuA-4uy9A:
undetectable		 1iiuA-4uy9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 5 LEU B  34
LEU B   6
ALA B 112
ALA B 108
LEU B  80
 None
 1.39A 1iiuA-4xsrB:
undetectable		 1iiuA-4xsrB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7

(Homo sapiens) 		PF03133
(TTL) 		5 LEU A 298
ALA A 474
ALA A 476
TYR A 469
LEU A 303
 None
 1.21A 1iiuA-4ylrA:
undetectable		 1iiuA-4ylrA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxf MUPS

(Pseudomonas
fluorescens) 		PF13561
(adh_short_C2) 		5 LEU A 132
LEU A 130
ALA A 168
ALA A 172
MET A 173
 None
 1.33A 1iiuA-4yxfA:
undetectable		 1iiuA-4yxfA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 LEU A 536
ALA A 313
ALA A 311
MET A 100
LEU A  89
 None
 1.36A 1iiuA-5a8rA:
undetectable		 1iiuA-5a8rA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 LEU A 592
ALA A 490
ALA A 494
MET A 495
TYR A 130
 None
 1.31A 1iiuA-5aeeA:
undetectable		 1iiuA-5aeeA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 LEU A1109
LEU A1114
ALA A 899
MET A 900
TYR A 903
 None
 1.09A 1iiuA-5amqA:
undetectable		 1iiuA-5amqA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwf DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 5 LEU A 145
LEU A 100
ALA A  58
ALA A  56
LEU A 152
 None
 1.38A 1iiuA-5cwfA:
undetectable		 1iiuA-5cwfA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 LEU A 145
ALA A 161
ALA A 157
MET A 156
LEU A 111
 None
None
None
None
ADP  A 401 (-4.2A)
 1.06A 1iiuA-5eqtA:
undetectable		 1iiuA-5eqtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 349
ALA A 418
ALA A 319
TYR A 415
ARG A 466
 None
 1.29A 1iiuA-5h3kA:
undetectable		 1iiuA-5h3kA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 349
ALA A 418
ALA A 319
TYR A 423
ARG A 466
 None
 1.12A 1iiuA-5h3kA:
undetectable		 1iiuA-5h3kA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU B 497
ALA B 520
MET B 515
TYR B 475
LEU B 468
 None
 1.25A 1iiuA-5hb4B:
undetectable		 1iiuA-5hb4B:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 5 LEU A 135
ALA A 242
ALA A 246
MET A 247
LEU A 185
 None
 1.19A 1iiuA-5hssA:
undetectable		 1iiuA-5hssA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		5 LEU B  98
ALA B  90
MET B   8
MET B  23
LEU B  29
 None
 1.33A 1iiuA-5kswB:
undetectable		 1iiuA-5kswB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		5 LEU A 107
ALA A 387
ALA A 384
TYR A 144
LEU A 154
 None
 1.34A 1iiuA-5ktkA:
undetectable		 1iiuA-5ktkA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkw PUTATIVE OMPA FAMILY
LIPOPROTEIN

(Burkholderia
cenocepacia) 		PF00691
(OmpA) 		5 LEU A  61
ALA A 123
ALA A 127
MET A 128
LEU A  90
 None
 1.42A 1iiuA-5lkwA:
undetectable		 1iiuA-5lkwA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		5 LEU A 115
ALA A 183
ALA A 187
LEU A 229
HIS A 129
 None
 1.07A 1iiuA-5m09A:
undetectable		 1iiuA-5m09A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 5 LEU A 165
ALA A 189
ALA A 193
LEU A 150
GLN A 147
 None
 1.36A 1iiuA-5muxA:
undetectable		 1iiuA-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 LEU A 578
LEU A 527
ALA A 511
LEU A 466
HIS A 459
 None
 1.25A 1iiuA-5tusA:
undetectable		 1iiuA-5tusA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 5 LEU A 285
ALA A 366
ALA A 362
TYR A 331
GLN A 282
 None
 1.26A 1iiuA-5u2oA:
undetectable		 1iiuA-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 136
ALA A 145
TYR A 270
LEU A 130
GLN A 131
 None
 1.41A 1iiuA-5ulvA:
undetectable		 1iiuA-5ulvA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Escherichia
coli) 		no annotation 5 LEU A 111
LEU A 103
ALA A  33
ALA A  35
LEU A  39
 None
 1.37A 1iiuA-5wlyA:
undetectable		 1iiuA-5wlyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 5 LEU A 661
ALA A  29
ALA A 506
LEU A  34
HIS A  92
 None
 1.41A 1iiuA-5xqoA:
undetectable		 1iiuA-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 5 LEU A 360
ALA A 337
TYR A 335
LEU A 302
GLN A 319
 None
 1.17A 1iiuA-6byxA:
undetectable		 1iiuA-6byxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 5 LEU A 327
LEU A 542
ALA A 486
ALA A 489
GLN A 533
 None
 1.40A 1iiuA-6etzA:
undetectable		 1iiuA-6etzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 5 LEU A2269
ALA A2031
TYR A2266
LEU A2248
HIS A2277
 None
 1.26A 1iiuA-6fayA:
undetectable		 1iiuA-6fayA:
undetectable