SIMILAR PATTERNS OF AMINO ACIDS FOR 1IGX_A_EPAA700_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoa T-FIMBRIN

(Homo sapiens) 		PF00307
(CH) 		5 VAL A 211
VAL A 165
SER A 203
ILE A 207
LEU A 230
 VAL  A 211 ( 0.6A)
VAL  A 165 ( 0.6A)
SER  A 203 ( 0.0A)
ILE  A 207 ( 0.7A)
LEU  A 230 ( 0.6A)
 1.34A 1igxA-1aoaA:
undetectable		 1igxA-1aoaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0u HISTIDINE PERMEASE

(Salmonella
enterica) 		PF00005
(ABC_tran) 		5 VAL A 174
VAL A 207
SER A  36
ILE A 224
LEU A  49
 None
 1.37A 1igxA-1b0uA:
0.0		 1igxA-1b0uA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)

(Escherichia
coli) 		PF02219
(MTHFR) 		4 ARG A  67
VAL A 136
ILE A  92
LEU A  89
 None
 0.90A 1igxA-1b5tA:
0.0		 1igxA-1b5tA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 VAL A 433
TYR A 255
VAL A 254
LEU A 435
 None
None
PC1  A 777 (-4.8A)
None
 0.82A 1igxA-1bp1A:
0.0		 1igxA-1bp1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 VAL A 251
TYR A 254
ILE A 263
LEU A 103
 None
 0.86A 1igxA-1bs0A:
0.0		 1igxA-1bs0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cee GTP-BINDING RHO-LIKE
PROTEIN

(Homo sapiens) 		PF00071
(Ras) 		5 VAL A  98
VAL A  93
SER A  89
ILE A 137
LEU A 112
 None
 1.35A 1igxA-1ceeA:
0.0		 1igxA-1ceeA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 VAL A   4
TYR A 261
VAL A 262
SER A 323
LEU A   7
 None
 0.98A 1igxA-1cg4A:
undetectable		 1igxA-1cg4A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A  91
VAL A  45
VAL A  47
LEU A  59
 None
 0.91A 1igxA-1civA:
0.0		 1igxA-1civA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmv HUMAN
CYTOMEGALOVIRUS
PROTEASE

(Human
betaherpesvirus
5) 		PF00716
(Peptidase_S21) 		4 VAL A 158
VAL A  14
VAL A  16
LEU A 160
 None
 0.84A 1igxA-1cmvA:
0.0		 1igxA-1cmvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 VAL A 261
VAL A 259
ILE A 167
LEU A 174
 None
 0.76A 1igxA-1d8cA:
0.7		 1igxA-1d8cA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 VAL A  56
VAL A 337
TYR A 391
LEU A 334
 None
 0.91A 1igxA-1d9zA:
undetectable		 1igxA-1d9zA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 VAL A 116
ARG A 120
VAL A 344
TYR A 348
VAL A 349
SER A 353
ILE A 523
LEU A 531
 None
SCL  A 700 (-3.9A)
None
None
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-3.4A)
OAS  A 530 (-4.1A)
 0.45A 1igxA-1ebvA:
61.2		 1igxA-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq9 CHYMOTRYPSIN

(Solenopsis
invicta) 		PF00089
(Trypsin) 		4 VAL A  59
VAL A  52
ILE A 212
LEU A  33
 None
 0.71A 1igxA-1eq9A:
undetectable		 1igxA-1eq9A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 VAL A 241
VAL A 316
VAL A 320
ILE A 234
 None
 0.92A 1igxA-1ex0A:
1.1		 1igxA-1ex0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f15 COAT PROTEIN

(Cucumber mosaic
virus) 		PF00760
(Cucumo_coat) 		4 TYR A  86
VAL A 187
ILE A 109
LEU A 199
 None
 0.91A 1igxA-1f15A:
undetectable		 1igxA-1f15A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL B 242
VAL B 246
SER B 250
ILE B 286
 None
 0.90A 1igxA-1ffvB:
0.7		 1igxA-1ffvB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fon PROCARBOXYPEPTIDASE
A-S6

(Bos taurus) 		PF00089
(Trypsin) 		4 VAL A  14
VAL A  97
ILE A  70
LEU A  16
 None
 0.85A 1igxA-1fonA:
undetectable		 1igxA-1fonA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 VAL A 374
VAL A 358
TYR A 236
VAL A 362
 None
 0.87A 1igxA-1gytA:
0.0		 1igxA-1gytA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE

(Escherichia
coli) 		PF01634
(HisG)
PF08029
(HisG_C) 		4 VAL A  66
ARG A   8
VAL A  53
ILE A  40
 None
 0.83A 1igxA-1h3dA:
undetectable		 1igxA-1h3dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hgx HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Tritrichomonas
suis) 		PF00156
(Pribosyltran) 		4 VAL A 143
VAL A  98
VAL A 100
LEU A 115
 None
 0.84A 1igxA-1hgxA:
undetectable		 1igxA-1hgxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		4 VAL A 116
VAL A 212
ILE A  29
LEU A 119
 None
 0.90A 1igxA-1hkhA:
undetectable		 1igxA-1hkhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1is7 GTP CYCLOHYDROLASE I

(Rattus
norvegicus) 		PF01227
(GTP_cyclohydroI) 		4 VAL A 163
VAL A 121
VAL A 123
LEU A 159
 None
 0.81A 1igxA-1is7A:
undetectable		 1igxA-1is7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 TYR A 870
VAL A 871
SER A 875
ILE A1056
 None
 0.87A 1igxA-1k32A:
undetectable		 1igxA-1k32A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI

(Pantoea
stewartii) 		PF00765
(Autoind_synth) 		5 VAL A  64
VAL A 190
VAL A 121
ILE A  55
LEU A   2
 None
 1.34A 1igxA-1k4jA:
undetectable		 1igxA-1k4jA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		4 VAL A  29
SER A  54
ILE A 131
LEU A 117
 None
 0.89A 1igxA-1kfwA:
undetectable		 1igxA-1kfwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 VAL A 246
VAL A 248
ILE A 338
LEU A 343
 None
 0.78A 1igxA-1lamA:
0.0		 1igxA-1lamA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 VAL A 528
VAL A 482
VAL A 484
LEU A 533
 None
 0.85A 1igxA-1lq2A:
undetectable		 1igxA-1lq2A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		4 VAL A 199
VAL A 195
SER A 191
LEU A 221
 None
 0.84A 1igxA-1lujA:
undetectable		 1igxA-1lujA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6j TRIOSEPHOSPHATE
ISOMERASE

(Entamoeba
histolytica) 		PF00121
(TIM) 		4 VAL A  42
VAL A  44
ILE A  21
LEU A  58
 None
 0.82A 1igxA-1m6jA:
undetectable		 1igxA-1m6jA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		4 TYR A 217
VAL A 246
SER A 279
ILE A 269
 None
 0.89A 1igxA-1m7jA:
undetectable		 1igxA-1m7jA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		4 VAL A 220
TYR A 250
ILE A 106
LEU A 223
 None
 0.91A 1igxA-1nj8A:
undetectable		 1igxA-1nj8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnl L-3-PHOSPHOSERINE
PHOSPHATASE

(Homo sapiens) 		PF00702
(Hydrolase) 		4 VAL A 105
VAL A  25
ILE A 177
LEU A 107
 None
 0.88A 1igxA-1nnlA:
undetectable		 1igxA-1nnlA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nww LIMONENE-1,2-EPOXIDE
HYDROLASE

(Rhodococcus
erythropolis) 		PF07858
(LEH) 		4 VAL A 119
TYR A  96
VAL A  95
LEU A 122
 None
 0.89A 1igxA-1nwwA:
undetectable		 1igxA-1nwwA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 VAL A  82
VAL A  33
VAL A  35
ILE A 394
LEU A 294
 None
 1.49A 1igxA-1odoA:
undetectable		 1igxA-1odoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 5 VAL A 116
VAL A   9
VAL A  94
ILE A 139
LEU A 104
 None
 1.27A 1igxA-1oy1A:
undetectable		 1igxA-1oy1A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 VAL A 146
VAL A 299
ILE A 216
LEU A 175
 None
 0.92A 1igxA-1pgsA:
undetectable		 1igxA-1pgsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		4 VAL A 353
SER A 337
ILE A 440
LEU A 355
 None
 0.79A 1igxA-1pjqA:
undetectable		 1igxA-1pjqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR

(Homo sapiens) 		PF00386
(C1q) 		4 VAL C 159
VAL C 161
ILE B 214
LEU C 181
 None
 0.89A 1igxA-1pk6C:
undetectable		 1igxA-1pk6C:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		4 VAL A  29
VAL A  98
SER A 121
LEU A  88
 None
 0.83A 1igxA-1q0zA:
undetectable		 1igxA-1q0zA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9c SON OF SEVENLESS
PROTEIN

(Homo sapiens) 		PF00125
(Histone) 		5 VAL A  30
TYR A  47
VAL A  48
ILE A 137
LEU A 142
 None
 1.09A 1igxA-1q9cA:
1.0		 1igxA-1q9cA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 VAL X 662
VAL X 731
VAL X 733
LEU X 712
 None
 0.91A 1igxA-1r6bX:
0.8		 1igxA-1r6bX:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shx EPHRIN-A5

(Mus musculus) 		PF00812
(Ephrin) 		4 VAL A  38
VAL A 163
VAL A 161
LEU A  62
 None
 0.90A 1igxA-1shxA:
undetectable		 1igxA-1shxA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 VAL A 130
VAL A 149
ILE A 220
LEU A 132
 None
 0.92A 1igxA-1suwA:
undetectable		 1igxA-1suwA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		4 VAL A  15
VAL A 151
VAL A 153
ILE A 166
 FMN  A 200 (-4.1A)
None
None
None
 0.69A 1igxA-1t0iA:
undetectable		 1igxA-1t0iA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t70 PHOSPHATASE

(Deinococcus
radiodurans) 		PF13277
(YmdB) 		4 ARG A  26
VAL A   9
VAL A  34
LEU A  22
 None
 0.91A 1igxA-1t70A:
undetectable		 1igxA-1t70A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE

(Mycobacterium
bovis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		5 VAL A 194
VAL A 251
VAL A 233
SER A 200
LEU A 208
 None
 1.48A 1igxA-1tdtA:
undetectable		 1igxA-1tdtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Homo sapiens) 		PF00574
(CLP_protease) 		4 VAL A  39
VAL A  43
ILE A  59
LEU A 102
 None
 0.88A 1igxA-1tg6A:
undetectable		 1igxA-1tg6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 VAL A  14
VAL A 164
VAL A 162
ILE A 229
LEU A  11
 None
 1.12A 1igxA-1udqA:
undetectable		 1igxA-1udqA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uen KIAA0343 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		4 VAL A  97
VAL A  25
VAL A  23
LEU A  95
 None
 0.88A 1igxA-1uenA:
undetectable		 1igxA-1uenA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugs NITRILE HYDRATASE
ALPHA SUBUNIT

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		4 VAL A 151
ARG A 140
VAL A 107
VAL A 159
 None
 0.88A 1igxA-1ugsA:
undetectable		 1igxA-1ugsA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upn ECHOVIRUS 11 COAT
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		4 VAL C  55
VAL C  53
SER C  51
LEU C 116
 None
 0.91A 1igxA-1upnC:
undetectable		 1igxA-1upnC:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqx LECTIN

(Ralstonia
solanacearum) 		PF07472
(PA-IIL) 		4 VAL A  91
VAL A  32
VAL A  30
LEU A 108
 None
 0.91A 1igxA-1uqxA:
undetectable		 1igxA-1uqxA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A  89
VAL A  91
SER A  93
ILE A  11
LEU A  19
 None
None
None
NAD  A 336 (-4.3A)
None
 1.32A 1igxA-1vc2A:
undetectable		 1igxA-1vc2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		5 VAL A 124
VAL A  64
VAL A  66
ILE A  68
LEU A  97
 None
None
None
SAM  A 302 (-3.7A)
None
 0.96A 1igxA-1ve3A:
undetectable		 1igxA-1ve3A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		4 VAL A  52
VAL A   1
SER A 171
ILE A 183
 None
 0.89A 1igxA-1wczA:
undetectable		 1igxA-1wczA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf0 TAR DNA-BINDING
PROTEIN-43

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL A   8
VAL A  10
ILE A  68
LEU A  22
 None
 0.85A 1igxA-1wf0A:
undetectable		 1igxA-1wf0A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 VAL A  93
VAL A  91
ILE A  57
LEU A 163
 None
 0.85A 1igxA-1wf3A:
undetectable		 1igxA-1wf3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlc CONGERIN II

(Conger
myriaster) 		PF00337
(Gal-bind_lectin) 		4 VAL A  19
VAL A  34
ILE A  99
LEU A  17
 None
 0.86A 1igxA-1wlcA:
undetectable		 1igxA-1wlcA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjv PROTECTION OF
TELOMERES 1

(Homo sapiens) 		PF02765
(POT1)
PF16686
(POT1PC) 		5 ARG A 276
VAL A  28
VAL A  79
SER A 103
ILE A  71
 None
 1.45A 1igxA-1xjvA:
undetectable		 1igxA-1xjvA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xln PUTIDAREDOXIN

(Pseudomonas
putida) 		PF00111
(Fer2) 		5 VAL A  17
VAL A  52
VAL A  99
ILE A  32
LEU A  23
 None
 1.22A 1igxA-1xlnA:
undetectable		 1igxA-1xlnA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 VAL A  87
VAL A  62
VAL A  60
LEU A  91
 None
 0.91A 1igxA-1xzqA:
undetectable		 1igxA-1xzqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y07 DESULFOFERRODOXIN
(RBO)

(Treponema
pallidum) 		PF01880
(Desulfoferrodox) 		4 VAL A  81
VAL A  56
VAL A  54
LEU A  83
 None
FE  A 503 ( 4.9A)
None
None
 0.92A 1igxA-1y07A:
undetectable		 1igxA-1y07A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yby TRANSLATION
ELONGATION FACTOR P

(Ruminiclostridium
thermocellum) 		PF01132
(EFP)
PF08207
(EFP_N)
PF09285
(Elong-fact-P_C) 		4 VAL A 111
VAL A 113
SER A 115
LEU A  93
 None
 0.92A 1igxA-1ybyA:
undetectable		 1igxA-1ybyA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf9 UBIQUITIN CARRIER
PROTEIN 4

(Leishmania
major) 		PF00179
(UQ_con) 		5 VAL A  42
VAL A  61
SER A  73
ILE A  97
LEU A 107
 None
 1.08A 1igxA-1yf9A:
undetectable		 1igxA-1yf9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		4 VAL A 158
VAL A 189
VAL A 191
ILE A  95
 GOL  A 702 ( 4.2A)
None
None
None
 0.88A 1igxA-1yjkA:
undetectable		 1igxA-1yjkA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Bacillus
subtilis) 		PF02547
(Queuosine_synth) 		5 VAL A 242
ARG A 243
VAL A  57
ILE A 291
LEU A 239
 None
 1.20A 1igxA-1yy3A:
undetectable		 1igxA-1yy3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 VAL A 130
VAL A 149
ILE A 220
LEU A 132
 None
 0.91A 1igxA-1z0uA:
undetectable		 1igxA-1z0uA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1znx GUANYLATE KINASE

(Mycobacterium
tuberculosis) 		PF00625
(Guanylate_kin) 		4 VAL A  37
VAL A 136
VAL A 138
LEU A 196
 None
 0.81A 1igxA-1znxA:
undetectable		 1igxA-1znxA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		4 VAL A 167
VAL A 165
SER A 163
ILE A 135
 None
 0.89A 1igxA-1ztvA:
undetectable		 1igxA-1ztvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ah5 COG0546: PREDICTED
PHOSPHATASES

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		4 VAL A 205
TYR A 103
ILE A   4
LEU A  96
 None
 0.92A 1igxA-2ah5A:
undetectable		 1igxA-2ah5A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 ARG A 270
VAL A 324
VAL A 322
LEU A 272
 None
 0.86A 1igxA-2b5mA:
undetectable		 1igxA-2b5mA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bu2 PYRUVATE
DEHYDROGENSAE KINASE
ISOENZYME 2

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 VAL A  73
TYR A 145
ILE A  56
LEU A  63
 None
 0.83A 1igxA-2bu2A:
undetectable		 1igxA-2bu2A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cub CYTOPLASMIC PROTEIN
NCK1

(Homo sapiens) 		PF14604
(SH3_9) 		4 VAL A  44
VAL A  42
ILE A  37
LEU A  34
 None
 0.85A 1igxA-2cubA:
undetectable		 1igxA-2cubA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 VAL A 197
TYR A 165
SER A 171
ILE A 173
LEU A 193
 None
 1.16A 1igxA-2cyaA:
undetectable		 1igxA-2cyaA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		5 ARG A  48
VAL A 536
VAL A 440
SER A 474
LEU A 517
 None
 1.13A 1igxA-2du7A:
0.6		 1igxA-2du7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e21 TRNA(ILE)-LYSIDINE
SYNTHASE

(Aquifex
aeolicus) 		PF01171
(ATP_bind_3) 		4 VAL A  35
VAL A  39
ILE A   8
LEU A 169
 None
 0.89A 1igxA-2e21A:
undetectable		 1igxA-2e21A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 VAL A  87
VAL A  65
ILE A  57
LEU A  89
 None
 0.91A 1igxA-2eidA:
undetectable		 1igxA-2eidA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 VAL A 268
VAL A 250
VAL A 255
ILE A 264
LEU A   9
 None
 1.39A 1igxA-2ftpA:
undetectable		 1igxA-2ftpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 VAL A  53
TYR A 107
SER A 160
ILE A 294
 None
STU  A 400 (-4.5A)
None
None
 0.88A 1igxA-2gcdA:
undetectable		 1igxA-2gcdA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqt UDP-N-ACETYLENOLPYRU
VYLGLUCOSAMINE
REDUCTASE

(Thermus
caldophilus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 VAL A 183
ARG A 187
VAL A  87
ILE A 104
 None
FAD  A 601 (-2.7A)
None
FAD  A 601 (-4.1A)
 0.91A 1igxA-2gqtA:
undetectable		 1igxA-2gqtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		4 VAL A 115
VAL A  61
VAL A  63
LEU A  90
 None
 0.66A 1igxA-2gs9A:
undetectable		 1igxA-2gs9A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A 335
VAL A  65
VAL A   5
ILE A  19
LEU A  69
 None
 1.38A 1igxA-2gz3A:
undetectable		 1igxA-2gz3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha9 UPF0210 PROTEIN
SP0239

(Streptococcus
pneumoniae) 		PF05167
(DUF711) 		5 VAL A 118
VAL A 395
VAL A 184
SER A 146
ILE A 133
 None
 1.40A 1igxA-2ha9A:
undetectable		 1igxA-2ha9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ARG A  36
VAL A  12
ILE A  67
LEU A  35
 None
 0.89A 1igxA-2ho4A:
undetectable		 1igxA-2ho4A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN

(Mycoplasma
arthritidis) 		PF09245
(MA-Mit) 		4 VAL G  52
VAL G  86
ILE G 100
LEU G 107
 None
 0.89A 1igxA-2icwG:
undetectable		 1igxA-2icwG:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		4 VAL A 373
VAL A 391
ILE A 273
LEU A 369
 None
 0.90A 1igxA-2iluA:
undetectable		 1igxA-2iluA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		4 VAL G 246
VAL G 296
ILE G 360
LEU G 305
 None
 0.91A 1igxA-2iouG:
undetectable		 1igxA-2iouG:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Escherichia
coli) 		PF00692
(dUTPase) 		4 VAL A 120
VAL A  33
VAL A  35
LEU A 107
 None
 0.63A 1igxA-2j4hA:
undetectable		 1igxA-2j4hA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jax HYPOTHETICAL PROTEIN
TB31.7

(Mycobacterium
tuberculosis) 		PF00582
(Usp) 		4 VAL A  91
VAL A  24
ILE A  10
LEU A  40
 None
 0.86A 1igxA-2jaxA:
undetectable		 1igxA-2jaxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jks BRADYZOITE SURFACE
ANTIGEN BSR4

(Toxoplasma
gondii) 		PF04092
(SAG) 		4 VAL A 174
VAL A 307
VAL A 305
LEU A 198
 None
 0.78A 1igxA-2jksA:
undetectable		 1igxA-2jksA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2js0 CYTOPLASMIC PROTEIN
NCK1

(Homo sapiens) 		PF14604
(SH3_9) 		4 VAL A  31
VAL A  29
ILE A  24
LEU A  21
 None
 0.90A 1igxA-2js0A:
undetectable		 1igxA-2js0A:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k75 UNCHARACTERIZED
PROTEIN TA0387

(Thermoplasma
acidophilum) 		no annotation 5 VAL A  84
VAL A   4
VAL A  18
ILE A  22
LEU A  82
 None
 1.38A 1igxA-2k75A:
undetectable		 1igxA-2k75A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7q FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		4 VAL A2030
VAL A2007
ILE A2009
LEU A1983
 None
 0.88A 1igxA-2k7qA:
undetectable		 1igxA-2k7qA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4q THIOREDOXIN

(Mycobacterium
tuberculosis) 		PF00085
(Thioredoxin) 		4 VAL A 111
VAL A  21
ILE A  50
LEU A  85
 None
 0.86A 1igxA-2l4qA:
undetectable		 1igxA-2l4qA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8j GAMMA-AMINOBUTYRIC
ACID
RECEPTOR-ASSOCIATED
PROTEIN-LIKE 1

(Homo sapiens) 		PF02991
(Atg8) 		5 VAL A  57
TYR A 106
VAL A 107
ILE A  84
LEU A  94
 None
 1.50A 1igxA-2l8jA:
undetectable		 1igxA-2l8jA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqn CRK-LIKE PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07653
(SH3_2) 		4 ARG A  57
VAL A 170
SER A 162
ILE A 152
 None
 0.86A 1igxA-2lqnA:
undetectable		 1igxA-2lqnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01933
(UPF0052) 		4 VAL A  60
VAL A   6
VAL A   8
LEU A  19
 None
 0.87A 1igxA-2o2zA:
undetectable		 1igxA-2o2zA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 INTERCELLULAR
ADHESION MOLECULE 1

(Homo sapiens) 		no annotation 4 VAL A 295
VAL A 288
VAL A 303
LEU A 363
 None
 0.87A 1igxA-2oz4A:
undetectable		 1igxA-2oz4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz6 VIRULENCE FACTOR
REGULATOR

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		4 VAL A 201
VAL A 144
VAL A 148
ILE A 172
 None
 0.81A 1igxA-2oz6A:
undetectable		 1igxA-2oz6A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz6 VIRULENCE FACTOR
REGULATOR

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		5 VAL A 210
VAL A 144
VAL A 148
ILE A 172
LEU A 195
 None
 1.50A 1igxA-2oz6A:
undetectable		 1igxA-2oz6A:
16.38