SIMILAR PATTERNS OF AMINO ACIDS FOR 1IGX_A_EPAA700_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a99 PUTRESCINE-BINDING
PROTEIN


(Escherichia
coli)
PF13416
(SBP_bac_8)
5 PHE A 276
TYR A 223
PHE A 266
GLY A 141
GLY A 246
PUT  A 371 (-4.0A)
None
None
None
None
1.10A 1igxA-1a99A:
undetectable
1igxA-1a99A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN


(Azotobacter
vinelandii)
PF13531
(SBP_bac_11)
5 GLY A 178
ALA A  88
SER A  87
GLY A 162
LEU A 161
None
1.12A 1igxA-1atgA:
undetectable
1igxA-1atgA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 LEU A 453
PHE A 388
GLY A 315
SER A 295
GLY A 293
None
None
None
None
FAD  A 510 ( 4.3A)
1.08A 1igxA-1coyA:
0.0
1igxA-1coyA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA


(Helicobacter
pylori)
PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1)
5 LEU A 106
GLY A 109
ALA B 440
GLY B 443
LEU B 562
None
1.07A 1igxA-1e9yA:
0.0
1igxA-1e9yA:
18.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE


(Ovis aries)
PF00008
(EGF)
PF03098
(An_peroxidase)
11 PHE A 205
PHE A 209
LEU A 352
TYR A 355
PHE A 381
TYR A 385
TRP A 387
GLY A 526
ALA A 527
GLY A 533
LEU A 534
OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
OAS  A 530 ( 4.7A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 4.0A)
OAS  A 530 ( 3.3A)
0.39A 1igxA-1ebvA:
61.2
1igxA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE


(Ovis aries)
PF00008
(EGF)
PF03098
(An_peroxidase)
6 PHE A 210
LEU A 352
TYR A 355
PHE A 381
GLY A 526
ALA A 527
HEM  A 601 (-4.7A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
OAS  A 530 ( 4.7A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
1.48A 1igxA-1ebvA:
61.2
1igxA-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum)
PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim)
5 PHE A 445
PHE A 418
LEU A 104
PHE A 414
GLY A 367
None
None
None
None
IPH  A 802 (-3.7A)
1.11A 1igxA-1fohA:
0.0
1igxA-1fohA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica)
PF00135
(COesterase)
6 PHE A 331
PHE A 290
TYR A 421
GLY A 203
SER A 200
GLY A 118
EMM  A1999 (-4.7A)
EMM  A1999 (-4.1A)
None
None
EMM  A1999 ( 1.4A)
SAF  A1998 ( 3.5A)
1.44A 1igxA-1gqrA:
0.0
1igxA-1gqrA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica)
PF00135
(COesterase)
6 PHE A 331
PHE A 290
TYR A 421
GLY A 227
SER A 200
GLY A 118
EMM  A1999 (-4.7A)
EMM  A1999 (-4.1A)
None
None
EMM  A1999 ( 1.4A)
SAF  A1998 ( 3.5A)
1.35A 1igxA-1gqrA:
0.0
1igxA-1gqrA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis)
PF07859
(Abhydrolase_3)
5 LEU A 268
TYR A 272
GLY A 126
SER A 202
LEU A 310
None
1.07A 1igxA-1jkmA:
0.0
1igxA-1jkmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E


(Homo sapiens)
PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core)
5 LEU A 185
PHE A 134
GLY A 287
GLY A 216
LEU A 219
CL  A 701 (-4.3A)
None
None
None
None
1.05A 1igxA-1nugA:
1.0
1igxA-1nugA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE


(Thermotoga
maritima)
PF04961
(FTCD_C)
5 GLY A  25
ALA A  26
SER A  29
GLY A  32
LEU A  73
None
0.79A 1igxA-1o5hA:
undetectable
1igxA-1o5hA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens)
PF00089
(Trypsin)
5 LEU A 155
TYR A  29
GLY A  44
ALA A  43
SER A 197
None
1.11A 1igxA-1orfA:
undetectable
1igxA-1orfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE


(Pseudomonas sp.
WBC-3)
PF00753
(Lactamase_B)
5 LEU A 180
GLY A 199
ALA A 202
GLY A 155
LEU A 156
None
1.14A 1igxA-1p9eA:
undetectable
1igxA-1p9eA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjs HEMOPEXIN

(Oryctolagus
cuniculus)
PF00045
(Hemopexin)
5 PHE A 113
PHE A  78
TYR A  86
GLY A 135
LEU A 149
None
1.10A 1igxA-1qjsA:
undetectable
1igxA-1qjsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuh HYPOTHETICAL PROTEIN
EGC068


(uncultured
bacterium)
PF12680
(SnoaL_2)
5 PHE A  75
PHE A  47
PHE A 124
GLY A 103
GLY A  31
None
1.08A 1igxA-1tuhA:
undetectable
1igxA-1tuhA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS


(Escherichia
coli)
PF04960
(Glutaminase)
5 LEU A 212
GLY A 258
ALA A 268
GLY A 265
LEU A 205
None
0.98A 1igxA-1u60A:
undetectable
1igxA-1u60A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE


(Pyrococcus
furiosus)
no annotation 5 LEU B 810
PHE B 759
TYR B 843
ALA B 752
GLY B 801
None
1.02A 1igxA-1us8B:
undetectable
1igxA-1us8B:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN


(Thermus
thermophilus)
PF02615
(Ldh_2)
5 PHE A 277
LEU A 264
GLY A 104
ALA A 100
GLY A 130
None
1.11A 1igxA-1x0aA:
undetectable
1igxA-1x0aA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE


(Escherichia
coli)
PF04996
(AstB)
5 LEU A  46
TYR A 402
GLY A  10
GLY A 362
LEU A 353
None
1.05A 1igxA-1yniA:
undetectable
1igxA-1yniA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON


(Salmonella
enterica)
PF01569
(PAP2)
5 PHE A  87
LEU A 110
GLY A 209
ALA A 160
GLY A 188
None
0.92A 1igxA-2akcA:
0.5
1igxA-2akcA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE


(Manduca sexta)
PF00135
(COesterase)
6 PHE A 361
PHE A 259
GLY A 253
ALA A 229
SER A 226
GLY A 146
TFC  A 600 (-4.4A)
TFC  A 600 (-4.0A)
None
None
TFC  A 600 (-1.4A)
TFC  A 600 (-3.4A)
1.50A 1igxA-2fj0A:
undetectable
1igxA-2fj0A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE


(Manduca sexta)
PF00135
(COesterase)
6 PHE A 361
PHE A 259
GLY A 253
ALA A 229
SER A 226
GLY A 147
TFC  A 600 (-4.4A)
TFC  A 600 (-4.0A)
None
None
TFC  A 600 (-1.4A)
TFC  A 600 (-3.6A)
1.45A 1igxA-2fj0A:
undetectable
1igxA-2fj0A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA


(Homo sapiens)
PF01504
(PIP5K)
5 LEU A 126
TYR A 189
GLY A  54
ALA A  56
SER A  58
None
0.95A 1igxA-2gk9A:
undetectable
1igxA-2gk9A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN


(Pseudomonas
stutzeri)
PF02332
(Phenol_Hydrox)
PF04945
(YHS)
5 PHE A 190
GLY C 142
ALA C 141
SER A 116
GLY A 119
None
1.13A 1igxA-2inpA:
undetectable
1igxA-2inpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum)
PF06748
(DUF1217)
5 PHE A 126
LEU A 153
GLY A 134
ALA A 135
LEU A 145
None
0.94A 1igxA-2o8sA:
undetectable
1igxA-2o8sA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po3 4-DEHYDRASE

(Streptomyces
venezuelae)
PF01041
(DegT_DnrJ_EryC1)
5 GLY A1066
ALA A1065
SER A1187
GLY A1189
LEU A1188
None
1.15A 1igxA-2po3A:
undetectable
1igxA-2po3A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT)
5 LEU G 502
TYR G 249
PHE G 496
GLY G 269
ALA G 270
None
1.07A 1igxA-2uv8G:
undetectable
1igxA-2uv8G:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae)
PF00756
(Esterase)
5 TYR A 163
GLY A  44
SER A 120
GLY A 144
LEU A 204
None
GOL  A1259 (-3.2A)
GOL  A1259 (-2.9A)
None
None
1.06A 1igxA-2uz0A:
undetectable
1igxA-2uz0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa)
PF00063
(Myosin_head)
5 PHE A 483
PHE A 665
GLY A 453
SER A 146
GLY A 662
None
1.11A 1igxA-2v26A:
undetectable
1igxA-2v26A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p
AQUAPORIN PIP2-7 7


(Komagataella
pastoris)
PF00230
(MIP)
5 LEU A  85
GLY A 220
ALA A 221
GLY A 171
LEU A 174
None
1.10A 1igxA-2w1pA:
0.1
1igxA-2w1pA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT


(Gallus gallus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 PHE M 475
LEU M 603
TYR M 611
GLY M 427
ALA M 430
None
1.08A 1igxA-2w4gM:
undetectable
1igxA-2w4gM:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE


(Severe acute
respiratory
syndrome-related
coronavirus)
PF06460
(NSP13)
5 LEU A  54
GLY A 208
ALA A 209
SER A 166
GLY A 164
None
None
None
NA  A1295 (-2.7A)
None
1.14A 1igxA-2xyqA:
undetectable
1igxA-2xyqA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2)
5 TYR A 181
GLY A 152
ALA A 153
SER A 156
GLY A 159
None
NAP  A 701 (-3.1A)
NAP  A 701 (-3.3A)
None
None
0.97A 1igxA-2y05A:
undetectable
1igxA-2y05A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3


(Saccharomyces
cerevisiae)
PF15612
(WHIM1)
5 PHE B 538
PHE B 566
ALA B 599
SER B 598
LEU B 554
None
1.12A 1igxA-2y9yB:
undetectable
1igxA-2y9yB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE


(Achromobacter
obae)
PF00202
(Aminotran_3)
5 GLY A  50
ALA A  51
SER A  53
GLY A  55
LEU A  54
None
1.10A 1igxA-2zukA:
undetectable
1igxA-2zukA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmc NTF2-LIKE PROTEIN

(Trichormus
variabilis)
PF12680
(SnoaL_2)
5 PHE A  63
PHE A  32
GLY A  16
GLY A  23
LEU A  24
None
1.05A 1igxA-3dmcA:
undetectable
1igxA-3dmcA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894


(Bacteroides
uniformis)
no annotation 5 PHE A 322
LEU A 286
GLY A 329
ALA A 330
LEU A  18
None
1.10A 1igxA-3dsmA:
undetectable
1igxA-3dsmA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19


(Rhodobacter
sphaeroides)
PF01244
(Peptidase_M19)
5 PHE A 305
TYR A 346
ALA A  49
GLY A  46
LEU A 320
None
1.11A 1igxA-3fdgA:
undetectable
1igxA-3fdgA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN


(Novosphingobium
aromaticivorans)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 PHE A 281
LEU A  47
TYR A 315
GLY A  97
GLY A  93
None
1.07A 1igxA-3gazA:
undetectable
1igxA-3gazA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A


(Pseudomonas
putida)
no annotation 5 TYR A  39
GLY A   9
ALA A  10
GLY A  18
LEU A 112
None
1.07A 1igxA-3ihmA:
undetectable
1igxA-3ihmA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8v FLAGELLIN HOMOLOG

(Sphingomonas
sp. A1)
PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF07196
(Flagellin_IN)
5 PHE A 142
LEU A  82
GLY A 315
GLY A  71
LEU A  74
None
0.97A 1igxA-3k8vA:
undetectable
1igxA-3k8vA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H


(Human
alphaherpesvirus
2)
PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
5 PHE A 411
LEU A 418
GLY A 384
ALA A 383
LEU A 254
None
1.14A 1igxA-3m1cA:
undetectable
1igxA-3m1cA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN


(Enterococcus
faecium)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
5 TYR A  86
GLY A 154
ALA A 391
GLY A 436
LEU A 427
None
1.02A 1igxA-3m4xA:
undetectable
1igxA-3m4xA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP


(Vibrio cholerae)
PF01554
(MatE)
5 LEU A  68
GLY A 295
ALA A 296
SER A 299
GLY A 303
None
1.11A 1igxA-3mktA:
undetectable
1igxA-3mktA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803)
PF00654
(Voltage_CLC)
5 LEU A 290
GLY A 138
ALA A 137
SER A 134
GLY A 131
None
0.93A 1igxA-3nd0A:
undetectable
1igxA-3nd0A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oce FUMARATE LYASE:DELTA
CRYSTALLIN


(Brucella
abortus)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 PHE A 203
LEU A 305
GLY A 184
GLY A 197
LEU A 196
None
None
None
EDO  A 475 ( 4.3A)
None
1.04A 1igxA-3oceA:
undetectable
1igxA-3oceA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
5 PHE B 146
GLY B  23
ALA B  25
GLY B  30
LEU B  31
None
1.14A 1igxA-3pdiB:
undetectable
1igxA-3pdiB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0r PORCINE CIRCOVIRUS 2
(PCV2) CAPSID
PROTEIN


(Porcine
circovirus 2)
PF02443
(Circo_capsid)
5 PHE A 100
PHE A 197
SER A 116
GLY A 194
LEU A 193
None
0.97A 1igxA-3r0rA:
undetectable
1igxA-3r0rA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r24 2'-O-METHYL
TRANSFERASE


(Severe acute
respiratory
syndrome-related
coronavirus)
PF06460
(NSP13)
5 LEU A  54
GLY A 208
ALA A 209
SER A 166
GLY A 164
None
1.15A 1igxA-3r24A:
undetectable
1igxA-3r24A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE


(Thermotoga
maritima)
PF00933
(Glyco_hydro_3)
5 LEU A 198
GLY A 143
ALA A 144
GLY A 149
LEU A 151
None
1.08A 1igxA-3wo8A:
undetectable
1igxA-3wo8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP


(Corynebacterium
glutamicum)
PF02028
(BCCT)
5 LEU A 440
GLY A 417
ALA A 420
GLY A 324
LEU A 447
None
1.11A 1igxA-4ainA:
0.0
1igxA-4ainA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1


(Homo sapiens)
PF01039
(Carboxyl_trans)
5 LEU A1737
GLY A1842
ALA A1841
SER A1844
GLY A1872
None
0.97A 1igxA-4asiA:
undetectable
1igxA-4asiA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ


(Haloferax
volcanii)
PF00091
(Tubulin)
5 PHE A  98
LEU A 267
GLY A 197
ALA A 196
GLY A 191
None
1.15A 1igxA-4b45A:
undetectable
1igxA-4b45A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus)
PF00973
(Paramyxo_ncap)
5 LEU A 297
TYR A 301
GLY A 266
GLY A 274
LEU A 275
None
0.95A 1igxA-4co6A:
undetectable
1igxA-4co6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE
PROTEIN DBF4 HOMOLOG
A


(Homo sapiens)
PF00069
(Pkinase)
PF07535
(zf-DBF)
5 PHE A 414
PHE B 253
GLY A 432
ALA A 455
LEU A 461
None
0.90A 1igxA-4f99A:
undetectable
1igxA-4f99A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fha DIHYDRODIPICOLINATE
SYNTHASE


(Streptococcus
pneumoniae)
PF00701
(DHDPS)
5 LEU A  46
TYR A 190
GLY A 107
ALA A 106
GLY A 103
None
1.12A 1igxA-4fhaA:
undetectable
1igxA-4fhaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE


(Plasmodium
falciparum)
PF00156
(Pribosyltran)
5 PHE A  98
LEU A 116
GLY A 137
GLY A 101
LEU A 103
None
1.13A 1igxA-4fymA:
undetectable
1igxA-4fymA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htl BETA-GLUCOSIDE
KINASE


(Listeria
monocytogenes)
PF00480
(ROK)
5 LEU A 287
TRP A 113
GLY A 281
ALA A 282
GLY A  16
None
1.10A 1igxA-4htlA:
undetectable
1igxA-4htlA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN


(Methanoculleus
marisnigri)
PF06550
(SPP)
5 PHE A 214
ALA A 136
SER A 135
GLY A 219
LEU A 221
None
1.13A 1igxA-4hydA:
undetectable
1igxA-4hydA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1


(Escherichia
coli)
PF07690
(MFS_1)
5 PHE A  49
LEU A 407
GLY A 414
ALA A 412
GLY A 144
NO2  A 501 (-4.8A)
None
None
None
None
1.08A 1igxA-4jreA:
undetectable
1igxA-4jreA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0d PERIPLASMIC SENSOR
HYBRID HISTIDINE
KINASE


(Anaeromyxobacter
dehalogenans)
no annotation 5 PHE A 162
GLY A 107
ALA A 108
SER A 111
LEU A 115
None
1.09A 1igxA-4k0dA:
undetectable
1igxA-4k0dA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAS-RELATED PROTEIN
RAP-1B


(Homo sapiens)
PF00071
(Ras)
5 TYR R  40
GLY R  60
ALA R  59
GLY R  10
LEU R   9
None
None
SO4  R 201 (-3.3A)
None
None
1.02A 1igxA-4mh0R:
undetectable
1igxA-4mh0R:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx9 FLAGELLIN

(Pseudomonas
aeruginosa)
PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
5 PHE A 141
LEU A  81
GLY A 318
GLY A  70
LEU A  73
None
1.11A 1igxA-4nx9A:
undetectable
1igxA-4nx9A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT


(Rhodopseudomonas
palustris)
PF03480
(DctP)
5 PHE A 118
GLY A  99
ALA A 109
GLY A 133
LEU A 132
None
0.98A 1igxA-4oanA:
undetectable
1igxA-4oanA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
5 PHE A 730
LEU A 861
ALA A 789
GLY A 678
LEU A 682
None
1.13A 1igxA-4okdA:
undetectable
1igxA-4okdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN


(Anaplasma
phagocytophilum)
PF01596
(Methyltransf_3)
5 GLY A  68
ALA A  71
SER A  70
GLY A  45
LEU A  48
None
None
SAM  A 301 (-2.9A)
None
None
0.98A 1igxA-4pclA:
undetectable
1igxA-4pclA:
16.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2


(Mus musculus)
PF00008
(EGF)
PF03098
(An_peroxidase)
12 PHE A 206
PHE A 210
LEU A 353
TYR A 356
PHE A 382
TYR A 386
TRP A 388
GLY A 527
ALA A 528
SER A 531
GLY A 534
LEU A 535
None
EDO  A 616 (-3.5A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
None
IBP  A 601 (-4.8A)
None
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
EDO  A 616 (-3.0A)
EDO  A 616 ( 4.4A)
0.53A 1igxA-4ph9A:
58.1
1igxA-4ph9A:
63.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2


(Mus musculus)
PF00008
(EGF)
PF03098
(An_peroxidase)
6 PHE A 211
LEU A 353
TYR A 356
PHE A 382
ALA A 528
SER A 531
HEM  A 602 (-4.6A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
None
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
1.50A 1igxA-4ph9A:
58.1
1igxA-4ph9A:
63.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202


(Phleum pratense)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 LEU A 183
ALA A 217
SER A 125
GLY A 126
LEU A 106
None
None
FAD  A 601 (-3.4A)
None
FAD  A 601 (-4.8A)
1.10A 1igxA-4pveA:
undetectable
1igxA-4pveA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
5 LEU A 442
GLY A 406
ALA A 407
SER A 410
GLY A 413
None
0.78A 1igxA-4qs9A:
undetectable
1igxA-4qs9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes)
PF00756
(Esterase)
5 TYR A 166
GLY A  47
SER A 123
GLY A 147
LEU A 207
None
1.13A 1igxA-4rotA:
undetectable
1igxA-4rotA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM1
ALGM2


(Sphingomonas
sp.)
PF00528
(BPD_transp_1)
5 PHE A 199
PHE A 142
TYR B 163
ALA B 199
LEU B 204
None
1.03A 1igxA-4tqvA:
undetectable
1igxA-4tqvA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus)
PF00840
(Glyco_hydro_7)
6 PHE A 344
PHE A 263
TYR A 336
GLY A 329
SER A 322
GLY A 269
None
1.43A 1igxA-4v20A:
undetectable
1igxA-4v20A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3


(Bifidobacterium
adolescentis)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 PHE A 509
TYR A 506
GLY A 570
ALA A 569
GLY A 565
None
0.80A 1igxA-4ye5A:
undetectable
1igxA-4ye5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynv ACL4

(Chaetomium
thermophilum)
PF13432
(TPR_16)
5 LEU A 263
ALA A 233
SER A 237
GLY A 239
LEU A 238
None
1.04A 1igxA-4ynvA:
undetectable
1igxA-4ynvA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A 731
GLY A 752
ALA A 751
GLY A 559
LEU A 557
None
1.08A 1igxA-4zdnA:
undetectable
1igxA-4zdnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amp CELLOBIOHYDROLASE I

(Galactomyces
candidus)
PF00840
(Glyco_hydro_7)
6 PHE A 341
PHE A 263
TYR A 333
GLY A 326
SER A 319
GLY A 269
None
None
None
PEG  A 901 ( 4.7A)
None
None
1.43A 1igxA-5ampA:
undetectable
1igxA-5ampA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana)
PF03514
(GRAS)
5 TYR A 625
ALA A 543
SER A 547
GLY A 549
LEU A 548
None
1.11A 1igxA-5b3hA:
undetectable
1igxA-5b3hA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE


(Mycolicibacterium
smegmatis)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A 250
ALA A 106
SER A 110
GLY A 111
LEU A 112
None
1.10A 1igxA-5bp1A:
undetectable
1igxA-5bp1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 PHE A 343
ALA A 482
SER A 486
GLY A 487
LEU A 412
None
1.11A 1igxA-5bs5A:
undetectable
1igxA-5bs5A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8e METHYLTRANSFERASE

(Mycobacterium
tuberculosis)
PF13847
(Methyltransf_31)
5 LEU A 165
PHE A 198
ALA A 173
SER A 196
GLY A 194
None
1.08A 1igxA-5f8eA:
undetectable
1igxA-5f8eA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH


(synthetic
construct)
PF00753
(Lactamase_B)
5 LEU A 147
GLY A 165
ALA A 168
GLY A 122
LEU A 123
None
1.10A 1igxA-5hifA:
undetectable
1igxA-5hifA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2


(Homo sapiens)
PF00008
(EGF)
PF03098
(An_peroxidase)
12 PHE A 205
PHE A 209
LEU A 352
TYR A 355
PHE A 381
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
GLY A 533
LEU A 534
None
None
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
None
0.59A 1igxA-5ikrA:
57.8
1igxA-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2


(Saccharomyces
cerevisiae)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 LEU B 361
PHE B 581
GLY B 584
GLY B 588
LEU B 566
None
0.90A 1igxA-5ip9B:
undetectable
1igxA-5ip9B:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE


(Mycobacterium
tuberculosis)
PF12697
(Abhydrolase_6)
5 LEU A  26
PHE A  88
GLY A  75
GLY A 116
LEU A  42
None
1.13A 1igxA-5jzbA:
undetectable
1igxA-5jzbA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425)
PF00881
(Nitroreductase)
5 PHE A 164
PHE A 188
GLY A 151
ALA A 152
LEU A 173
None
0.98A 1igxA-5lq4A:
undetectable
1igxA-5lq4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2y TSSK C

(Escherichia
coli)
PF05936
(T6SS_VasE)
5 PHE A 345
PHE A 426
GLY A 369
GLY A 332
LEU A 334
None
1.12A 1igxA-5m2yA:
undetectable
1igxA-5m2yA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-)
no annotation 5 PHE A 425
LEU A 245
PHE A 264
TRP A 261
ALA A 470
None
1.00A 1igxA-5oltA:
undetectable
1igxA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE


(Escherichia
coli)
no annotation 5 GLY A 176
ALA A 177
SER A 180
GLY A 182
LEU A 184
None
1.03A 1igxA-5oonA:
undetectable
1igxA-5oonA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
5 PHE A 378
TYR A 119
TYR A 403
GLY A 132
SER A 134
None
1.13A 1igxA-5t9gA:
undetectable
1igxA-5t9gA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4n FRUCTOSE-1

(Neisseria
gonorrhoeae)
PF01116
(F_bP_aldolase)
5 PHE A 203
GLY A 155
ALA A 154
SER A 197
GLY A 233
None
None
None
None
PO4  A 401 ( 3.2A)
1.14A 1igxA-5u4nA:
0.3
1igxA-5u4nA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum)
no annotation 5 PHE A 415
LEU A 448
ALA A 462
GLY A 459
LEU A 451
None
1.13A 1igxA-5v2dA:
undetectable
1igxA-5v2dA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
5 PHE A 210
TYR A 416
GLY A 193
ALA A 194
LEU A 201
None
1.13A 1igxA-5w1uA:
undetectable
1igxA-5w1uA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5was HOMOSERINE KINASE

(Corynebacterium
glutamicum)
no annotation 6 LEU C 273
GLY A  30
ALA A  20
SER A  19
GLY A 101
LEU A 100
None
None
None
None
PO4  A 401 (-4.0A)
None
1.46A 1igxA-5wasC:
undetectable
1igxA-5wasC:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 LEU B 354
PHE B 574
GLY B 577
GLY B 581
LEU B 559
None
1.11A 1igxA-5xogB:
undetectable
1igxA-5xogB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE


(Helicobacter
pylori)
no annotation 5 PHE A  92
LEU A  97
GLY A   3
ALA A  52
GLY A  60
None
1.01A 1igxA-5xukA:
undetectable
1igxA-5xukA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR


(Galdieria
sulphuraria)
PF03151
(TPT)
5 PHE A 272
GLY A 211
ALA A 212
SER A 215
LEU A 219
OLC  A 507 (-4.8A)
None
None
None
None
0.91A 1igxA-5y79A:
undetectable
1igxA-5y79A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR


(Galdieria
sulphuraria)
PF03151
(TPT)
5 PHE A 272
GLY A 211
ALA A 212
SER A 215
LEU A 219
OLC  A 507 (-4.8A)
None
None
None
None
1.01A 1igxA-5y79A:
undetectable
1igxA-5y79A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE


(Glaciozyma
antarctica)
no annotation 5 TYR A  29
GLY A  47
ALA A  48
GLY A 113
LEU A  40
None
1.10A 1igxA-5yhpA:
undetectable
1igxA-5yhpA:
19.56