SIMILAR PATTERNS OF AMINO ACIDS FOR 1IGX_A_EPAA700_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a99 | PUTRESCINE-BINDINGPROTEIN (Escherichiacoli) |
PF13416(SBP_bac_8) | 5 | PHE A 276TYR A 223PHE A 266GLY A 141GLY A 246 | PUT A 371 (-4.0A)NoneNoneNoneNone | 1.10A | 1igxA-1a99A:undetectable | 1igxA-1a99A:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1atg | PERIPLASMICMOLYBDATE-BINDINGPROTEIN (Azotobactervinelandii) |
PF13531(SBP_bac_11) | 5 | GLY A 178ALA A 88SER A 87GLY A 162LEU A 161 | None | 1.12A | 1igxA-1atgA:undetectable | 1igxA-1atgA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1coy | CHOLESTEROL OXIDASE (Brevibacteriumsterolicum) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | LEU A 453PHE A 388GLY A 315SER A 295GLY A 293 | NoneNoneNoneNoneFAD A 510 ( 4.3A) | 1.08A | 1igxA-1coyA:0.0 | 1igxA-1coyA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT ALPHAUREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF00547(Urease_gamma)PF00699(Urease_beta)PF01979(Amidohydro_1) | 5 | LEU A 106GLY A 109ALA B 440GLY B 443LEU B 562 | None | 1.07A | 1igxA-1e9yA:0.0 | 1igxA-1e9yA:18.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 11 | PHE A 205PHE A 209LEU A 352TYR A 355PHE A 381TYR A 385TRP A 387GLY A 526ALA A 527GLY A 533LEU A 534 | OAS A 530 ( 4.7A)NoneSCL A 700 ( 4.8A)SCL A 700 (-4.3A)OAS A 530 ( 4.7A)NoneNoneSCL A 700 ( 4.0A)SCL A 700 (-2.9A)OAS A 530 ( 4.0A)OAS A 530 ( 3.3A) | 0.39A | 1igxA-1ebvA:61.2 | 1igxA-1ebvA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 6 | PHE A 210LEU A 352TYR A 355PHE A 381GLY A 526ALA A 527 | HEM A 601 (-4.7A)SCL A 700 ( 4.8A)SCL A 700 (-4.3A)OAS A 530 ( 4.7A)SCL A 700 ( 4.0A)SCL A 700 (-2.9A) | 1.48A | 1igxA-1ebvA:61.2 | 1igxA-1ebvA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1foh | PHENOL HYDROXYLASE (Cutaneotrichosporoncutaneum) |
PF01494(FAD_binding_3)PF07976(Phe_hydrox_dim) | 5 | PHE A 445PHE A 418LEU A 104PHE A 414GLY A 367 | NoneNoneNoneNoneIPH A 802 (-3.7A) | 1.11A | 1igxA-1fohA:0.0 | 1igxA-1fohA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gqr | ACETYLCHOLINESTERASE (Tetronarcecalifornica) |
PF00135(COesterase) | 6 | PHE A 331PHE A 290TYR A 421GLY A 203SER A 200GLY A 118 | EMM A1999 (-4.7A)EMM A1999 (-4.1A)NoneNoneEMM A1999 ( 1.4A)SAF A1998 ( 3.5A) | 1.44A | 1igxA-1gqrA:0.0 | 1igxA-1gqrA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gqr | ACETYLCHOLINESTERASE (Tetronarcecalifornica) |
PF00135(COesterase) | 6 | PHE A 331PHE A 290TYR A 421GLY A 227SER A 200GLY A 118 | EMM A1999 (-4.7A)EMM A1999 (-4.1A)NoneNoneEMM A1999 ( 1.4A)SAF A1998 ( 3.5A) | 1.35A | 1igxA-1gqrA:0.0 | 1igxA-1gqrA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jkm | BREFELDIN A ESTERASE (Bacillussubtilis) |
PF07859(Abhydrolase_3) | 5 | LEU A 268TYR A 272GLY A 126SER A 202LEU A 310 | None | 1.07A | 1igxA-1jkmA:0.0 | 1igxA-1jkmA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nug | PROTEIN-GLUTAMINEGLUTAMYLTRANSFERASEE (Homo sapiens) |
PF00868(Transglut_N)PF00927(Transglut_C)PF01841(Transglut_core) | 5 | LEU A 185PHE A 134GLY A 287GLY A 216LEU A 219 | CL A 701 (-4.3A)NoneNoneNoneNone | 1.05A | 1igxA-1nugA:1.0 | 1igxA-1nugA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5h | FORMIMINOTETRAHYDROFOLATE CYCLODEAMINASE (Thermotogamaritima) |
PF04961(FTCD_C) | 5 | GLY A 25ALA A 26SER A 29GLY A 32LEU A 73 | None | 0.79A | 1igxA-1o5hA:undetectable | 1igxA-1o5hA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1orf | GRANZYME A (Homo sapiens) |
PF00089(Trypsin) | 5 | LEU A 155TYR A 29GLY A 44ALA A 43SER A 197 | None | 1.11A | 1igxA-1orfA:undetectable | 1igxA-1orfA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9e | METHYL PARATHIONHYDROLASE (Pseudomonas sp.WBC-3) |
PF00753(Lactamase_B) | 5 | LEU A 180GLY A 199ALA A 202GLY A 155LEU A 156 | None | 1.14A | 1igxA-1p9eA:undetectable | 1igxA-1p9eA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qjs | HEMOPEXIN (Oryctolaguscuniculus) |
PF00045(Hemopexin) | 5 | PHE A 113PHE A 78TYR A 86GLY A 135LEU A 149 | None | 1.10A | 1igxA-1qjsA:undetectable | 1igxA-1qjsA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tuh | HYPOTHETICAL PROTEINEGC068 (unculturedbacterium) |
PF12680(SnoaL_2) | 5 | PHE A 75PHE A 47PHE A 124GLY A 103GLY A 31 | None | 1.08A | 1igxA-1tuhA:undetectable | 1igxA-1tuhA:12.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u60 | PROBABLE GLUTAMINASEYBAS (Escherichiacoli) |
PF04960(Glutaminase) | 5 | LEU A 212GLY A 258ALA A 268GLY A 265LEU A 205 | None | 0.98A | 1igxA-1u60A:undetectable | 1igxA-1u60A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1us8 | DNA DOUBLE-STRANDBREAK REPAIR RAD50ATPASE (Pyrococcusfuriosus) |
no annotation | 5 | LEU B 810PHE B 759TYR B 843ALA B 752GLY B 801 | None | 1.02A | 1igxA-1us8B:undetectable | 1igxA-1us8B:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x0a | MALATE/L-LACTATEDEHYDROGENASE FAMILYPROTEIN (Thermusthermophilus) |
PF02615(Ldh_2) | 5 | PHE A 277LEU A 264GLY A 104ALA A 100GLY A 130 | None | 1.11A | 1igxA-1x0aA:undetectable | 1igxA-1x0aA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yni | SUCCINYLARGININEDIHYDROLASE (Escherichiacoli) |
PF04996(AstB) | 5 | LEU A 46TYR A 402GLY A 10GLY A 362LEU A 353 | None | 1.05A | 1igxA-1yniA:undetectable | 1igxA-1yniA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2akc | CLASS A NONSPECIFICACID PHOSPHATASEPHON (Salmonellaenterica) |
PF01569(PAP2) | 5 | PHE A 87LEU A 110GLY A 209ALA A 160GLY A 188 | None | 0.92A | 1igxA-2akcA:0.5 | 1igxA-2akcA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fj0 | CARBOXYLIC ESTERHYDROLASE (Manduca sexta) |
PF00135(COesterase) | 6 | PHE A 361PHE A 259GLY A 253ALA A 229SER A 226GLY A 146 | TFC A 600 (-4.4A)TFC A 600 (-4.0A)NoneNoneTFC A 600 (-1.4A)TFC A 600 (-3.4A) | 1.50A | 1igxA-2fj0A:undetectable | 1igxA-2fj0A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fj0 | CARBOXYLIC ESTERHYDROLASE (Manduca sexta) |
PF00135(COesterase) | 6 | PHE A 361PHE A 259GLY A 253ALA A 229SER A 226GLY A 147 | TFC A 600 (-4.4A)TFC A 600 (-4.0A)NoneNoneTFC A 600 (-1.4A)TFC A 600 (-3.6A) | 1.45A | 1igxA-2fj0A:undetectable | 1igxA-2fj0A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk9 | PHOSPHATIDYLINOSITOL-4-PHOSPHATE5-KINASE, TYPE II,GAMMA (Homo sapiens) |
PF01504(PIP5K) | 5 | LEU A 126TYR A 189GLY A 54ALA A 56SER A 58 | None | 0.95A | 1igxA-2gk9A:undetectable | 1igxA-2gk9A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inp | PHENOL HYDROXYLASECOMPONENT PHLPHENOL HYDROXYLASECOMPONENT PHN (Pseudomonasstutzeri) |
PF02332(Phenol_Hydrox)PF04945(YHS) | 5 | PHE A 190GLY C 142ALA C 141SER A 116GLY A 119 | None | 1.13A | 1igxA-2inpA:undetectable | 1igxA-2inpA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o8s | AGR_C_984P (Agrobacteriumfabrum) |
PF06748(DUF1217) | 5 | PHE A 126LEU A 153GLY A 134ALA A 135LEU A 145 | None | 0.94A | 1igxA-2o8sA:undetectable | 1igxA-2o8sA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po3 | 4-DEHYDRASE (Streptomycesvenezuelae) |
PF01041(DegT_DnrJ_EryC1) | 5 | GLY A1066ALA A1065SER A1187GLY A1189LEU A1188 | None | 1.15A | 1igxA-2po3A:undetectable | 1igxA-2po3A:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uv8 | FATTY ACID SYNTHASESUBUNIT BETA (FAS1) (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF01575(MaoC_dehydratas)PF08354(DUF1729)PF13452(MaoC_dehydrat_N)PF16073(SAT) | 5 | LEU G 502TYR G 249PHE G 496GLY G 269ALA G 270 | None | 1.07A | 1igxA-2uv8G:undetectable | 1igxA-2uv8G:14.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uz0 | TRIBUTYRIN ESTERASE (Streptococcuspneumoniae) |
PF00756(Esterase) | 5 | TYR A 163GLY A 44SER A 120GLY A 144LEU A 204 | NoneGOL A1259 (-3.2A)GOL A1259 (-2.9A)NoneNone | 1.06A | 1igxA-2uz0A:undetectable | 1igxA-2uz0A:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v26 | MYOSIN VI (Sus scrofa) |
PF00063(Myosin_head) | 5 | PHE A 483PHE A 665GLY A 453SER A 146GLY A 662 | None | 1.11A | 1igxA-2v26A:undetectable | 1igxA-2v26A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w1p | AQUAPORIN PIP2-7 7 (Komagataellapastoris) |
PF00230(MIP) | 5 | LEU A 85GLY A 220ALA A 221GLY A 171LEU A 174 | None | 1.10A | 1igxA-2w1pA:0.1 | 1igxA-2w1pA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4g | MYOSIN HEAVY CHAIN,SKELETAL MUSCLE,ADULT (Gallus gallus) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | PHE M 475LEU M 603TYR M 611GLY M 427ALA M 430 | None | 1.08A | 1igxA-2w4gM:undetectable | 1igxA-2w4gM:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xyq | PUTATIVE 2'-O-METHYLTRANSFERASE (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF06460(NSP13) | 5 | LEU A 54GLY A 208ALA A 209SER A 166GLY A 164 | NoneNoneNone NA A1295 (-2.7A)None | 1.14A | 1igxA-2xyqA:undetectable | 1igxA-2xyqA:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y05 | PROSTAGLANDINREDUCTASE 1 (Homo sapiens) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 5 | TYR A 181GLY A 152ALA A 153SER A 156GLY A 159 | NoneNAP A 701 (-3.1A)NAP A 701 (-3.3A)NoneNone | 0.97A | 1igxA-2y05A:undetectable | 1igxA-2y05A:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y9y | ISWI ONE COMPLEXPROTEIN 3 (Saccharomycescerevisiae) |
PF15612(WHIM1) | 5 | PHE B 538PHE B 566ALA B 599SER B 598LEU B 554 | None | 1.12A | 1igxA-2y9yB:undetectable | 1igxA-2y9yB:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zuk | ALPHA-AMINO-EPSILON-CAPROLACTAM RACEMASE (Achromobacterobae) |
PF00202(Aminotran_3) | 5 | GLY A 50ALA A 51SER A 53GLY A 55LEU A 54 | None | 1.10A | 1igxA-2zukA:undetectable | 1igxA-2zukA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dmc | NTF2-LIKE PROTEIN (Trichormusvariabilis) |
PF12680(SnoaL_2) | 5 | PHE A 63PHE A 32GLY A 16GLY A 23LEU A 24 | None | 1.05A | 1igxA-3dmcA:undetectable | 1igxA-3dmcA:13.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dsm | UNCHARACTERIZEDPROTEIN BACUNI_02894 (Bacteroidesuniformis) |
no annotation | 5 | PHE A 322LEU A 286GLY A 329ALA A 330LEU A 18 | None | 1.10A | 1igxA-3dsmA:undetectable | 1igxA-3dsmA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdg | DIPEPTIDASE AC.METALLO PEPTIDASE.MEROPS FAMILY M19 (Rhodobactersphaeroides) |
PF01244(Peptidase_M19) | 5 | PHE A 305TYR A 346ALA A 49GLY A 46LEU A 320 | None | 1.11A | 1igxA-3fdgA:undetectable | 1igxA-3fdgA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gaz | ALCOHOLDEHYDROGENASESUPERFAMILY PROTEIN (Novosphingobiumaromaticivorans) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | PHE A 281LEU A 47TYR A 315GLY A 97GLY A 93 | None | 1.07A | 1igxA-3gazA:undetectable | 1igxA-3gazA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihm | STYRENEMONOOXYGENASE A (Pseudomonasputida) |
no annotation | 5 | TYR A 39GLY A 9ALA A 10GLY A 18LEU A 112 | None | 1.07A | 1igxA-3ihmA:undetectable | 1igxA-3ihmA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8v | FLAGELLIN HOMOLOG (Sphingomonassp. A1) |
PF00669(Flagellin_N)PF00700(Flagellin_C)PF07196(Flagellin_IN) | 5 | PHE A 142LEU A 82GLY A 315GLY A 71LEU A 74 | None | 0.97A | 1igxA-3k8vA:undetectable | 1igxA-3k8vA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1c | ENVELOPEGLYCOPROTEIN H (Humanalphaherpesvirus2) |
PF02489(Herpes_glycop_H)PF17488(Herpes_glycoH_C) | 5 | PHE A 411LEU A 418GLY A 384ALA A 383LEU A 254 | None | 1.14A | 1igxA-3m1cA:undetectable | 1igxA-3m1cA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m4x | NOL1/NOP2/SUN FAMILYPROTEIN (Enterococcusfaecium) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 5 | TYR A 86GLY A 154ALA A 391GLY A 436LEU A 427 | None | 1.02A | 1igxA-3m4xA:undetectable | 1igxA-3m4xA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mkt | MULTI ANTIMICROBIALEXTRUSION PROTEIN(NA(+)/DRUGANTIPORTER)MATE-LIKE MDR EFFLUXPUMP (Vibrio cholerae) |
PF01554(MatE) | 5 | LEU A 68GLY A 295ALA A 296SER A 299GLY A 303 | None | 1.11A | 1igxA-3mktA:undetectable | 1igxA-3mktA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nd0 | SLL0855 PROTEIN (Synechocystissp. PCC 6803) |
PF00654(Voltage_CLC) | 5 | LEU A 290GLY A 138ALA A 137SER A 134GLY A 131 | None | 0.93A | 1igxA-3nd0A:undetectable | 1igxA-3nd0A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oce | FUMARATE LYASE:DELTACRYSTALLIN (Brucellaabortus) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | PHE A 203LEU A 305GLY A 184GLY A 197LEU A 196 | NoneNoneNoneEDO A 475 ( 4.3A)None | 1.04A | 1igxA-3oceA:undetectable | 1igxA-3oceA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pdi | NITROGENASE MOFECOFACTORBIOSYNTHESIS PROTEINNIFN (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 5 | PHE B 146GLY B 23ALA B 25GLY B 30LEU B 31 | None | 1.14A | 1igxA-3pdiB:undetectable | 1igxA-3pdiB:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0r | PORCINE CIRCOVIRUS 2(PCV2) CAPSIDPROTEIN (Porcinecircovirus 2) |
PF02443(Circo_capsid) | 5 | PHE A 100PHE A 197SER A 116GLY A 194LEU A 193 | None | 0.97A | 1igxA-3r0rA:undetectable | 1igxA-3r0rA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r24 | 2'-O-METHYLTRANSFERASE (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF06460(NSP13) | 5 | LEU A 54GLY A 208ALA A 209SER A 166GLY A 164 | None | 1.15A | 1igxA-3r24A:undetectable | 1igxA-3r24A:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wo8 | BETA-N-ACETYLGLUCOSAMINIDASE (Thermotogamaritima) |
PF00933(Glyco_hydro_3) | 5 | LEU A 198GLY A 143ALA A 144GLY A 149LEU A 151 | None | 1.08A | 1igxA-3wo8A:undetectable | 1igxA-3wo8A:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ain | GLYCINE BETAINETRANSPORTER BETP (Corynebacteriumglutamicum) |
PF02028(BCCT) | 5 | LEU A 440GLY A 417ALA A 420GLY A 324LEU A 447 | None | 1.11A | 1igxA-4ainA:0.0 | 1igxA-4ainA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4asi | ACETYL-COACARBOXYLASE 1 (Homo sapiens) |
PF01039(Carboxyl_trans) | 5 | LEU A1737GLY A1842ALA A1841SER A1844GLY A1872 | None | 0.97A | 1igxA-4asiA:undetectable | 1igxA-4asiA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b45 | CELL DIVISIONPROTEIN FTSZ (Haloferaxvolcanii) |
PF00091(Tubulin) | 5 | PHE A 98LEU A 267GLY A 197ALA A 196GLY A 191 | None | 1.15A | 1igxA-4b45A:undetectable | 1igxA-4b45A:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4co6 | NUCLEOPROTEIN (Nipahhenipavirus) |
PF00973(Paramyxo_ncap) | 5 | LEU A 297TYR A 301GLY A 266GLY A 274LEU A 275 | None | 0.95A | 1igxA-4co6A:undetectable | 1igxA-4co6A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f99 | CELL DIVISION CYCLE7-RELATED PROTEINKINASEPROTEIN DBF4 HOMOLOGA (Homo sapiens) |
PF00069(Pkinase)PF07535(zf-DBF) | 5 | PHE A 414PHE B 253GLY A 432ALA A 455LEU A 461 | None | 0.90A | 1igxA-4f99A:undetectable | 1igxA-4f99A:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fha | DIHYDRODIPICOLINATESYNTHASE (Streptococcuspneumoniae) |
PF00701(DHDPS) | 5 | LEU A 46TYR A 190GLY A 107ALA A 106GLY A 103 | None | 1.12A | 1igxA-4fhaA:undetectable | 1igxA-4fhaA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fym | OROTATEPHOSPHORIBOSYLTRANSFERASE (Plasmodiumfalciparum) |
PF00156(Pribosyltran) | 5 | PHE A 98LEU A 116GLY A 137GLY A 101LEU A 103 | None | 1.13A | 1igxA-4fymA:undetectable | 1igxA-4fymA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4htl | BETA-GLUCOSIDEKINASE (Listeriamonocytogenes) |
PF00480(ROK) | 5 | LEU A 287TRP A 113GLY A 281ALA A 282GLY A 16 | None | 1.10A | 1igxA-4htlA:undetectable | 1igxA-4htlA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyd | PUTATIVEUNCHARACTERIZEDPROTEIN (Methanoculleusmarisnigri) |
PF06550(SPP) | 5 | PHE A 214ALA A 136SER A 135GLY A 219LEU A 221 | None | 1.13A | 1igxA-4hydA:undetectable | 1igxA-4hydA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jre | NITRITE EXTRUSIONPROTEIN 1 (Escherichiacoli) |
PF07690(MFS_1) | 5 | PHE A 49LEU A 407GLY A 414ALA A 412GLY A 144 | NO2 A 501 (-4.8A)NoneNoneNoneNone | 1.08A | 1igxA-4jreA:undetectable | 1igxA-4jreA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0d | PERIPLASMIC SENSORHYBRID HISTIDINEKINASE (Anaeromyxobacterdehalogenans) |
no annotation | 5 | PHE A 162GLY A 107ALA A 108SER A 111LEU A 115 | None | 1.09A | 1igxA-4k0dA:undetectable | 1igxA-4k0dA:12.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mh0 | RAS-RELATED PROTEINRAP-1B (Homo sapiens) |
PF00071(Ras) | 5 | TYR R 40GLY R 60ALA R 59GLY R 10LEU R 9 | NoneNoneSO4 R 201 (-3.3A)NoneNone | 1.02A | 1igxA-4mh0R:undetectable | 1igxA-4mh0R:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nx9 | FLAGELLIN (Pseudomonasaeruginosa) |
PF00669(Flagellin_N)PF00700(Flagellin_C) | 5 | PHE A 141LEU A 81GLY A 318GLY A 70LEU A 73 | None | 1.11A | 1igxA-4nx9A:undetectable | 1igxA-4nx9A:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oan | TRAP DICARBOXYLATETRANSPORTER DCTPSUBUNIT (Rhodopseudomonaspalustris) |
PF03480(DctP) | 5 | PHE A 118GLY A 99ALA A 109GLY A 133LEU A 132 | None | 0.98A | 1igxA-4oanA:undetectable | 1igxA-4oanA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okd | ISOAMYLASE (Chlamydomonasreinhardtii) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | PHE A 730LEU A 861ALA A 789GLY A 678LEU A 682 | None | 1.13A | 1igxA-4okdA:undetectable | 1igxA-4okdA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pcl | O-METHYLTRANSFERASEFAMILY PROTEIN (Anaplasmaphagocytophilum) |
PF01596(Methyltransf_3) | 5 | GLY A 68ALA A 71SER A 70GLY A 45LEU A 48 | NoneNoneSAM A 301 (-2.9A)NoneNone | 0.98A | 1igxA-4pclA:undetectable | 1igxA-4pclA:16.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 12 | PHE A 206PHE A 210LEU A 353TYR A 356PHE A 382TYR A 386TRP A 388GLY A 527ALA A 528SER A 531GLY A 534LEU A 535 | NoneEDO A 616 (-3.5A)IBP A 601 ( 4.7A)IBP A 601 (-4.5A)NoneIBP A 601 (-4.8A)NoneIBP A 601 (-3.9A)IBP A 601 (-3.4A)IBP A 601 ( 3.3A)EDO A 616 (-3.0A)EDO A 616 ( 4.4A) | 0.53A | 1igxA-4ph9A:58.1 | 1igxA-4ph9A:63.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 6 | PHE A 211LEU A 353TYR A 356PHE A 382ALA A 528SER A 531 | HEM A 602 (-4.6A)IBP A 601 ( 4.7A)IBP A 601 (-4.5A)NoneIBP A 601 (-3.4A)IBP A 601 ( 3.3A) | 1.50A | 1igxA-4ph9A:58.1 | 1igxA-4ph9A:63.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pve | POLLEN ALLERGEN PHLP 4.0202 (Phleum pratense) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | LEU A 183ALA A 217SER A 125GLY A 126LEU A 106 | NoneNoneFAD A 601 (-3.4A)NoneFAD A 601 (-4.8A) | 1.10A | 1igxA-4pveA:undetectable | 1igxA-4pveA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qs9 | HEXOKINASE-1 (Arabidopsisthaliana) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 5 | LEU A 442GLY A 406ALA A 407SER A 410GLY A 413 | None | 0.78A | 1igxA-4qs9A:undetectable | 1igxA-4qs9A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rot | ESTERASE A (Streptococcuspyogenes) |
PF00756(Esterase) | 5 | TYR A 166GLY A 47SER A 123GLY A 147LEU A 207 | None | 1.13A | 1igxA-4rotA:undetectable | 1igxA-4rotA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqv | ALGM1ALGM2 (Sphingomonassp.) |
PF00528(BPD_transp_1) | 5 | PHE A 199PHE A 142TYR B 163ALA B 199LEU B 204 | None | 1.03A | 1igxA-4tqvA:undetectable | 1igxA-4tqvA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v20 | CELLOBIOHYDROLASE (Aspergillusfumigatus) |
PF00840(Glyco_hydro_7) | 6 | PHE A 344PHE A 263TYR A 336GLY A 329SER A 322GLY A 269 | None | 1.43A | 1igxA-4v20A:undetectable | 1igxA-4v20A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ye5 | PEPTIDOGLYCANSYNTHETASEPENICILLIN-BINDINGPROTEIN 3 (Bifidobacteriumadolescentis) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | PHE A 509TYR A 506GLY A 570ALA A 569GLY A 565 | None | 0.80A | 1igxA-4ye5A:undetectable | 1igxA-4ye5A:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynv | ACL4 (Chaetomiumthermophilum) |
PF13432(TPR_16) | 5 | LEU A 263ALA A 233SER A 237GLY A 239LEU A 238 | None | 1.04A | 1igxA-4ynvA:undetectable | 1igxA-4ynvA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdn | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 731GLY A 752ALA A 751GLY A 559LEU A 557 | None | 1.08A | 1igxA-4zdnA:undetectable | 1igxA-4zdnA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5amp | CELLOBIOHYDROLASE I (Galactomycescandidus) |
PF00840(Glyco_hydro_7) | 6 | PHE A 341PHE A 263TYR A 333GLY A 326SER A 319GLY A 269 | NoneNoneNonePEG A 901 ( 4.7A)NoneNone | 1.43A | 1igxA-5ampA:undetectable | 1igxA-5ampA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3h | PROTEIN SCARECROW (Arabidopsisthaliana) |
PF03514(GRAS) | 5 | TYR A 625ALA A 543SER A 547GLY A 549LEU A 548 | None | 1.11A | 1igxA-5b3hA:undetectable | 1igxA-5b3hA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp1 | MYCOCEROSIC ACIDSYNTHASE (Mycolicibacteriumsmegmatis) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 250ALA A 106SER A 110GLY A 111LEU A 112 | None | 1.10A | 1igxA-5bp1A:undetectable | 1igxA-5bp1A:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bs5 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | PHE A 343ALA A 482SER A 486GLY A 487LEU A 412 | None | 1.11A | 1igxA-5bs5A:undetectable | 1igxA-5bs5A:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f8e | METHYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF13847(Methyltransf_31) | 5 | LEU A 165PHE A 198ALA A 173SER A 196GLY A 194 | None | 1.08A | 1igxA-5f8eA:undetectable | 1igxA-5f8eA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hif | RECONSTRUCTEDLACTONASE ANCESTOR,ANC1-MPH (syntheticconstruct) |
PF00753(Lactamase_B) | 5 | LEU A 147GLY A 165ALA A 168GLY A 122LEU A 123 | None | 1.10A | 1igxA-5hifA:undetectable | 1igxA-5hifA:20.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 12 | PHE A 205PHE A 209LEU A 352TYR A 355PHE A 381TYR A 385TRP A 387GLY A 526ALA A 527SER A 530GLY A 533LEU A 534 | NoneNoneID8 A 601 (-4.1A)ID8 A 601 (-3.8A)NoneID8 A 601 ( 3.5A)COH A 602 (-4.5A)ID8 A 601 (-3.5A)ID8 A 601 (-3.5A)ID8 A 601 (-2.7A)NoneNone | 0.59A | 1igxA-5ikrA:57.8 | 1igxA-5ikrA:63.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ip9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB2 (Saccharomycescerevisiae) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 5 | LEU B 361PHE B 581GLY B 584GLY B 588LEU B 566 | None | 0.90A | 1igxA-5ip9B:undetectable | 1igxA-5ip9B:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jzb | 4,5:9,10-DISECO-3-HYDROXY-5,9,17-TRIOXOANDROSTA-1(10),2-DIENE-4-OATE HYDROLASE (Mycobacteriumtuberculosis) |
PF12697(Abhydrolase_6) | 5 | LEU A 26PHE A 88GLY A 75GLY A 116LEU A 42 | None | 1.13A | 1igxA-5jzbA:undetectable | 1igxA-5jzbA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lq4 | CYAGOX (Cyanothece sp.PCC 7425) |
PF00881(Nitroreductase) | 5 | PHE A 164PHE A 188GLY A 151ALA A 152LEU A 173 | None | 0.98A | 1igxA-5lq4A:undetectable | 1igxA-5lq4A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m2y | TSSK C (Escherichiacoli) |
PF05936(T6SS_VasE) | 5 | PHE A 345PHE A 426GLY A 369GLY A 332LEU A 334 | None | 1.12A | 1igxA-5m2yA:undetectable | 1igxA-5m2yA:12.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5olt | - (-) |
no annotation | 5 | PHE A 425LEU A 245PHE A 264TRP A 261ALA A 470 | None | 1.00A | 1igxA-5oltA:undetectable | 1igxA-5oltA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oon | UNDECAPRENYL-DIPHOSPHATASE (Escherichiacoli) |
no annotation | 5 | GLY A 176ALA A 177SER A 180GLY A 182LEU A 184 | None | 1.03A | 1igxA-5oonA:undetectable | 1igxA-5oonA:8.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t9g | GLYCOSIDE HYDROLASE (Bacteroidesuniformis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | PHE A 378TYR A 119TYR A 403GLY A 132SER A 134 | None | 1.13A | 1igxA-5t9gA:undetectable | 1igxA-5t9gA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4n | FRUCTOSE-1 (Neisseriagonorrhoeae) |
PF01116(F_bP_aldolase) | 5 | PHE A 203GLY A 155ALA A 154SER A 197GLY A 233 | NoneNoneNoneNonePO4 A 401 ( 3.2A) | 1.14A | 1igxA-5u4nA:0.3 | 1igxA-5u4nA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v2d | DIOXYGENASE (Pseudomonasbrassicacearum) |
no annotation | 5 | PHE A 415LEU A 448ALA A 462GLY A 459LEU A 451 | None | 1.13A | 1igxA-5v2dA:undetectable | 1igxA-5v2dA:9.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 5 | PHE A 210TYR A 416GLY A 193ALA A 194LEU A 201 | None | 1.13A | 1igxA-5w1uA:undetectable | 1igxA-5w1uA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5was | HOMOSERINE KINASE (Corynebacteriumglutamicum) |
no annotation | 6 | LEU C 273GLY A 30ALA A 20SER A 19GLY A 101LEU A 100 | NoneNoneNoneNonePO4 A 401 (-4.0A)None | 1.46A | 1igxA-5wasC:undetectable | 1igxA-5wasC:8.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Komagataellaphaffii) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 5 | LEU B 354PHE B 574GLY B 577GLY B 581LEU B 559 | None | 1.11A | 1igxA-5xogB:undetectable | 1igxA-5xogB:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xuk | HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE (Helicobacterpylori) |
no annotation | 5 | PHE A 92LEU A 97GLY A 3ALA A 52GLY A 60 | None | 1.01A | 1igxA-5xukA:undetectable | 1igxA-5xukA:9.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y79 | PUTATIVE HEXOSEPHOSPHATETRANSLOCATOR (Galdieriasulphuraria) |
PF03151(TPT) | 5 | PHE A 272GLY A 211ALA A 212SER A 215LEU A 219 | OLC A 507 (-4.8A)NoneNoneNoneNone | 0.91A | 1igxA-5y79A:undetectable | 1igxA-5y79A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y79 | PUTATIVE HEXOSEPHOSPHATETRANSLOCATOR (Galdieriasulphuraria) |
PF03151(TPT) | 5 | PHE A 272GLY A 211ALA A 212SER A 215LEU A 219 | OLC A 507 (-4.8A)NoneNoneNoneNone | 1.01A | 1igxA-5y79A:undetectable | 1igxA-5y79A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yhp | COLD ACTIVE PROLINEIMINOPEPTIDASE (Glaciozymaantarctica) |
no annotation | 5 | TYR A 29GLY A 47ALA A 48GLY A 113LEU A 40 | None | 1.10A | 1igxA-5yhpA:undetectable | 1igxA-5yhpA:19.56 |