SIMILAR PATTERNS OF AMINO ACIDS FOR 1IGX_A_EPAA700

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a99 PUTRESCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 PHE A 276
TYR A 223
PHE A 266
GLY A 141
GLY A 246
 PUT  A 371 (-4.0A)
None
None
None
None
 1.10A 1igxA-1a99A:
undetectable		 1igxA-1a99A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN

(Azotobacter
vinelandii) 		PF13531
(SBP_bac_11) 		5 GLY A 178
ALA A  88
SER A  87
GLY A 162
LEU A 161
 None
 1.12A 1igxA-1atgA:
undetectable		 1igxA-1atgA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 453
PHE A 388
GLY A 315
SER A 295
GLY A 293
 None
None
None
None
FAD  A 510 ( 4.3A)
 1.08A 1igxA-1coyA:
0.0		 1igxA-1coyA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 LEU A 106
GLY A 109
ALA B 440
GLY B 443
LEU B 562
 None
 1.07A 1igxA-1e9yA:
0.0		 1igxA-1e9yA:
18.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 PHE A 205
PHE A 209
LEU A 352
TYR A 355
PHE A 381
TYR A 385
TRP A 387
GLY A 526
ALA A 527
GLY A 533
LEU A 534
 OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
OAS  A 530 ( 4.7A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 4.0A)
OAS  A 530 ( 3.3A)
 0.39A 1igxA-1ebvA:
61.2		 1igxA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 PHE A 210
LEU A 352
TYR A 355
PHE A 381
GLY A 526
ALA A 527
 HEM  A 601 (-4.7A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
OAS  A 530 ( 4.7A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 1.48A 1igxA-1ebvA:
61.2		 1igxA-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 PHE A 445
PHE A 418
LEU A 104
PHE A 414
GLY A 367
 None
None
None
None
IPH  A 802 (-3.7A)
 1.11A 1igxA-1fohA:
0.0		 1igxA-1fohA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		6 PHE A 331
PHE A 290
TYR A 421
GLY A 203
SER A 200
GLY A 118
 EMM  A1999 (-4.7A)
EMM  A1999 (-4.1A)
None
None
EMM  A1999 ( 1.4A)
SAF  A1998 ( 3.5A)
 1.44A 1igxA-1gqrA:
0.0		 1igxA-1gqrA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		6 PHE A 331
PHE A 290
TYR A 421
GLY A 227
SER A 200
GLY A 118
 EMM  A1999 (-4.7A)
EMM  A1999 (-4.1A)
None
None
EMM  A1999 ( 1.4A)
SAF  A1998 ( 3.5A)
 1.35A 1igxA-1gqrA:
0.0		 1igxA-1gqrA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		5 LEU A 268
TYR A 272
GLY A 126
SER A 202
LEU A 310
 None
 1.07A 1igxA-1jkmA:
0.0		 1igxA-1jkmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 LEU A 185
PHE A 134
GLY A 287
GLY A 216
LEU A 219
 CL  A 701 (-4.3A)
None
None
None
None
 1.05A 1igxA-1nugA:
1.0		 1igxA-1nugA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE

(Thermotoga
maritima) 		PF04961
(FTCD_C) 		5 GLY A  25
ALA A  26
SER A  29
GLY A  32
LEU A  73
 None
 0.79A 1igxA-1o5hA:
undetectable		 1igxA-1o5hA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A 155
TYR A  29
GLY A  44
ALA A  43
SER A 197
 None
 1.11A 1igxA-1orfA:
undetectable		 1igxA-1orfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		5 LEU A 180
GLY A 199
ALA A 202
GLY A 155
LEU A 156
 None
 1.14A 1igxA-1p9eA:
undetectable		 1igxA-1p9eA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjs HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		5 PHE A 113
PHE A  78
TYR A  86
GLY A 135
LEU A 149
 None
 1.10A 1igxA-1qjsA:
undetectable		 1igxA-1qjsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuh HYPOTHETICAL PROTEIN
EGC068

(uncultured
bacterium) 		PF12680
(SnoaL_2) 		5 PHE A  75
PHE A  47
PHE A 124
GLY A 103
GLY A  31
 None
 1.08A 1igxA-1tuhA:
undetectable		 1igxA-1tuhA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 LEU A 212
GLY A 258
ALA A 268
GLY A 265
LEU A 205
 None
 0.98A 1igxA-1u60A:
undetectable		 1igxA-1u60A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		no annotation 5 LEU B 810
PHE B 759
TYR B 843
ALA B 752
GLY B 801
 None
 1.02A 1igxA-1us8B:
undetectable		 1igxA-1us8B:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN

(Thermus
thermophilus) 		PF02615
(Ldh_2) 		5 PHE A 277
LEU A 264
GLY A 104
ALA A 100
GLY A 130
 None
 1.11A 1igxA-1x0aA:
undetectable		 1igxA-1x0aA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		5 LEU A  46
TYR A 402
GLY A  10
GLY A 362
LEU A 353
 None
 1.05A 1igxA-1yniA:
undetectable		 1igxA-1yniA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON

(Salmonella
enterica) 		PF01569
(PAP2) 		5 PHE A  87
LEU A 110
GLY A 209
ALA A 160
GLY A 188
 None
 0.92A 1igxA-2akcA:
0.5		 1igxA-2akcA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		6 PHE A 361
PHE A 259
GLY A 253
ALA A 229
SER A 226
GLY A 146
 TFC  A 600 (-4.4A)
TFC  A 600 (-4.0A)
None
None
TFC  A 600 (-1.4A)
TFC  A 600 (-3.4A)
 1.50A 1igxA-2fj0A:
undetectable		 1igxA-2fj0A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		6 PHE A 361
PHE A 259
GLY A 253
ALA A 229
SER A 226
GLY A 147
 TFC  A 600 (-4.4A)
TFC  A 600 (-4.0A)
None
None
TFC  A 600 (-1.4A)
TFC  A 600 (-3.6A)
 1.45A 1igxA-2fj0A:
undetectable		 1igxA-2fj0A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		5 LEU A 126
TYR A 189
GLY A  54
ALA A  56
SER A  58
 None
 0.95A 1igxA-2gk9A:
undetectable		 1igxA-2gk9A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		5 PHE A 190
GLY C 142
ALA C 141
SER A 116
GLY A 119
 None
 1.13A 1igxA-2inpA:
undetectable		 1igxA-2inpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		5 PHE A 126
LEU A 153
GLY A 134
ALA A 135
LEU A 145
 None
 0.94A 1igxA-2o8sA:
undetectable		 1igxA-2o8sA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po3 4-DEHYDRASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A1066
ALA A1065
SER A1187
GLY A1189
LEU A1188
 None
 1.15A 1igxA-2po3A:
undetectable		 1igxA-2po3A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 LEU G 502
TYR G 249
PHE G 496
GLY G 269
ALA G 270
 None
 1.07A 1igxA-2uv8G:
undetectable		 1igxA-2uv8G:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		5 TYR A 163
GLY A  44
SER A 120
GLY A 144
LEU A 204
 None
GOL  A1259 (-3.2A)
GOL  A1259 (-2.9A)
None
None
 1.06A 1igxA-2uz0A:
undetectable		 1igxA-2uz0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 PHE A 483
PHE A 665
GLY A 453
SER A 146
GLY A 662
 None
 1.11A 1igxA-2v26A:
undetectable		 1igxA-2v26A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p
AQUAPORIN PIP2-7 7

(Komagataella
pastoris) 		PF00230
(MIP) 		5 LEU A  85
GLY A 220
ALA A 221
GLY A 171
LEU A 174
 None
 1.10A 1igxA-2w1pA:
0.1		 1igxA-2w1pA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 PHE M 475
LEU M 603
TYR M 611
GLY M 427
ALA M 430
 None
 1.08A 1igxA-2w4gM:
undetectable		 1igxA-2w4gM:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		5 LEU A  54
GLY A 208
ALA A 209
SER A 166
GLY A 164
 None
None
None
NA  A1295 (-2.7A)
None
 1.14A 1igxA-2xyqA:
undetectable		 1igxA-2xyqA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 TYR A 181
GLY A 152
ALA A 153
SER A 156
GLY A 159
 None
NAP  A 701 (-3.1A)
NAP  A 701 (-3.3A)
None
None
 0.97A 1igxA-2y05A:
undetectable		 1igxA-2y05A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF15612
(WHIM1) 		5 PHE B 538
PHE B 566
ALA B 599
SER B 598
LEU B 554
 None
 1.12A 1igxA-2y9yB:
undetectable		 1igxA-2y9yB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		5 GLY A  50
ALA A  51
SER A  53
GLY A  55
LEU A  54
 None
 1.10A 1igxA-2zukA:
undetectable		 1igxA-2zukA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmc NTF2-LIKE PROTEIN

(Trichormus
variabilis) 		PF12680
(SnoaL_2) 		5 PHE A  63
PHE A  32
GLY A  16
GLY A  23
LEU A  24
 None
 1.05A 1igxA-3dmcA:
undetectable		 1igxA-3dmcA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 5 PHE A 322
LEU A 286
GLY A 329
ALA A 330
LEU A  18
 None
 1.10A 1igxA-3dsmA:
undetectable		 1igxA-3dsmA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		5 PHE A 305
TYR A 346
ALA A  49
GLY A  46
LEU A 320
 None
 1.11A 1igxA-3fdgA:
undetectable		 1igxA-3fdgA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 281
LEU A  47
TYR A 315
GLY A  97
GLY A  93
 None
 1.07A 1igxA-3gazA:
undetectable		 1igxA-3gazA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A

(Pseudomonas
putida) 		no annotation 5 TYR A  39
GLY A   9
ALA A  10
GLY A  18
LEU A 112
 None
 1.07A 1igxA-3ihmA:
undetectable		 1igxA-3ihmA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8v FLAGELLIN HOMOLOG

(Sphingomonas
sp. A1) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF07196
(Flagellin_IN) 		5 PHE A 142
LEU A  82
GLY A 315
GLY A  71
LEU A  74
 None
 0.97A 1igxA-3k8vA:
undetectable		 1igxA-3k8vA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 PHE A 411
LEU A 418
GLY A 384
ALA A 383
LEU A 254
 None
 1.14A 1igxA-3m1cA:
undetectable		 1igxA-3m1cA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 TYR A  86
GLY A 154
ALA A 391
GLY A 436
LEU A 427
 None
 1.02A 1igxA-3m4xA:
undetectable		 1igxA-3m4xA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP

(Vibrio cholerae) 		PF01554
(MatE) 		5 LEU A  68
GLY A 295
ALA A 296
SER A 299
GLY A 303
 None
 1.11A 1igxA-3mktA:
undetectable		 1igxA-3mktA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 LEU A 290
GLY A 138
ALA A 137
SER A 134
GLY A 131
 None
 0.93A 1igxA-3nd0A:
undetectable		 1igxA-3nd0A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oce FUMARATE LYASE:DELTA
CRYSTALLIN

(Brucella
abortus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 PHE A 203
LEU A 305
GLY A 184
GLY A 197
LEU A 196
 None
None
None
EDO  A 475 ( 4.3A)
None
 1.04A 1igxA-3oceA:
undetectable		 1igxA-3oceA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 PHE B 146
GLY B  23
ALA B  25
GLY B  30
LEU B  31
 None
 1.14A 1igxA-3pdiB:
undetectable		 1igxA-3pdiB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0r PORCINE CIRCOVIRUS 2
(PCV2) CAPSID
PROTEIN

(Porcine
circovirus 2) 		PF02443
(Circo_capsid) 		5 PHE A 100
PHE A 197
SER A 116
GLY A 194
LEU A 193
 None
 0.97A 1igxA-3r0rA:
undetectable		 1igxA-3r0rA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r24 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		5 LEU A  54
GLY A 208
ALA A 209
SER A 166
GLY A 164
 None
 1.15A 1igxA-3r24A:
undetectable		 1igxA-3r24A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		5 LEU A 198
GLY A 143
ALA A 144
GLY A 149
LEU A 151
 None
 1.08A 1igxA-3wo8A:
undetectable		 1igxA-3wo8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		5 LEU A 440
GLY A 417
ALA A 420
GLY A 324
LEU A 447
 None
 1.11A 1igxA-4ainA:
0.0		 1igxA-4ainA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 LEU A1737
GLY A1842
ALA A1841
SER A1844
GLY A1872
 None
 0.97A 1igxA-4asiA:
undetectable		 1igxA-4asiA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 PHE A  98
LEU A 267
GLY A 197
ALA A 196
GLY A 191
 None
 1.15A 1igxA-4b45A:
undetectable		 1igxA-4b45A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus) 		PF00973
(Paramyxo_ncap) 		5 LEU A 297
TYR A 301
GLY A 266
GLY A 274
LEU A 275
 None
 0.95A 1igxA-4co6A:
undetectable		 1igxA-4co6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE
PROTEIN DBF4 HOMOLOG
A

(Homo sapiens) 		PF00069
(Pkinase)
PF07535
(zf-DBF) 		5 PHE A 414
PHE B 253
GLY A 432
ALA A 455
LEU A 461
 None
 0.90A 1igxA-4f99A:
undetectable		 1igxA-4f99A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fha DIHYDRODIPICOLINATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00701
(DHDPS) 		5 LEU A  46
TYR A 190
GLY A 107
ALA A 106
GLY A 103
 None
 1.12A 1igxA-4fhaA:
undetectable		 1igxA-4fhaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		5 PHE A  98
LEU A 116
GLY A 137
GLY A 101
LEU A 103
 None
 1.13A 1igxA-4fymA:
undetectable		 1igxA-4fymA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htl BETA-GLUCOSIDE
KINASE

(Listeria
monocytogenes) 		PF00480
(ROK) 		5 LEU A 287
TRP A 113
GLY A 281
ALA A 282
GLY A  16
 None
 1.10A 1igxA-4htlA:
undetectable		 1igxA-4htlA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN

(Methanoculleus
marisnigri) 		PF06550
(SPP) 		5 PHE A 214
ALA A 136
SER A 135
GLY A 219
LEU A 221
 None
 1.13A 1igxA-4hydA:
undetectable		 1igxA-4hydA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		5 PHE A  49
LEU A 407
GLY A 414
ALA A 412
GLY A 144
 NO2  A 501 (-4.8A)
None
None
None
None
 1.08A 1igxA-4jreA:
undetectable		 1igxA-4jreA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0d PERIPLASMIC SENSOR
HYBRID HISTIDINE
KINASE

(Anaeromyxobacter
dehalogenans) 		no annotation 5 PHE A 162
GLY A 107
ALA A 108
SER A 111
LEU A 115
 None
 1.09A 1igxA-4k0dA:
undetectable		 1igxA-4k0dA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAS-RELATED PROTEIN
RAP-1B

(Homo sapiens) 		PF00071
(Ras) 		5 TYR R  40
GLY R  60
ALA R  59
GLY R  10
LEU R   9
 None
None
SO4  R 201 (-3.3A)
None
None
 1.02A 1igxA-4mh0R:
undetectable		 1igxA-4mh0R:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx9 FLAGELLIN

(Pseudomonas
aeruginosa) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		5 PHE A 141
LEU A  81
GLY A 318
GLY A  70
LEU A  73
 None
 1.11A 1igxA-4nx9A:
undetectable		 1igxA-4nx9A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		5 PHE A 118
GLY A  99
ALA A 109
GLY A 133
LEU A 132
 None
 0.98A 1igxA-4oanA:
undetectable		 1igxA-4oanA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PHE A 730
LEU A 861
ALA A 789
GLY A 678
LEU A 682
 None
 1.13A 1igxA-4okdA:
undetectable		 1igxA-4okdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN

(Anaplasma
phagocytophilum) 		PF01596
(Methyltransf_3) 		5 GLY A  68
ALA A  71
SER A  70
GLY A  45
LEU A  48
 None
None
SAM  A 301 (-2.9A)
None
None
 0.98A 1igxA-4pclA:
undetectable		 1igxA-4pclA:
16.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 PHE A 206
PHE A 210
LEU A 353
TYR A 356
PHE A 382
TYR A 386
TRP A 388
GLY A 527
ALA A 528
SER A 531
GLY A 534
LEU A 535
 None
EDO  A 616 (-3.5A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
None
IBP  A 601 (-4.8A)
None
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
EDO  A 616 (-3.0A)
EDO  A 616 ( 4.4A)
 0.53A 1igxA-4ph9A:
58.1		 1igxA-4ph9A:
63.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 PHE A 211
LEU A 353
TYR A 356
PHE A 382
ALA A 528
SER A 531
 HEM  A 602 (-4.6A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
None
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
 1.50A 1igxA-4ph9A:
58.1		 1igxA-4ph9A:
63.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 183
ALA A 217
SER A 125
GLY A 126
LEU A 106
 None
None
FAD  A 601 (-3.4A)
None
FAD  A 601 (-4.8A)
 1.10A 1igxA-4pveA:
undetectable		 1igxA-4pveA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 LEU A 442
GLY A 406
ALA A 407
SER A 410
GLY A 413
 None
 0.78A 1igxA-4qs9A:
undetectable		 1igxA-4qs9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes) 		PF00756
(Esterase) 		5 TYR A 166
GLY A  47
SER A 123
GLY A 147
LEU A 207
 None
 1.13A 1igxA-4rotA:
undetectable		 1igxA-4rotA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM1
ALGM2

(Sphingomonas
sp.) 		PF00528
(BPD_transp_1) 		5 PHE A 199
PHE A 142
TYR B 163
ALA B 199
LEU B 204
 None
 1.03A 1igxA-4tqvA:
undetectable		 1igxA-4tqvA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		6 PHE A 344
PHE A 263
TYR A 336
GLY A 329
SER A 322
GLY A 269
 None
 1.43A 1igxA-4v20A:
undetectable		 1igxA-4v20A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 PHE A 509
TYR A 506
GLY A 570
ALA A 569
GLY A 565
 None
 0.80A 1igxA-4ye5A:
undetectable		 1igxA-4ye5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynv ACL4

(Chaetomium
thermophilum) 		PF13432
(TPR_16) 		5 LEU A 263
ALA A 233
SER A 237
GLY A 239
LEU A 238
 None
 1.04A 1igxA-4ynvA:
undetectable		 1igxA-4ynvA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 731
GLY A 752
ALA A 751
GLY A 559
LEU A 557
 None
 1.08A 1igxA-4zdnA:
undetectable		 1igxA-4zdnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amp CELLOBIOHYDROLASE I

(Galactomyces
candidus) 		PF00840
(Glyco_hydro_7) 		6 PHE A 341
PHE A 263
TYR A 333
GLY A 326
SER A 319
GLY A 269
 None
None
None
PEG  A 901 ( 4.7A)
None
None
 1.43A 1igxA-5ampA:
undetectable		 1igxA-5ampA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		5 TYR A 625
ALA A 543
SER A 547
GLY A 549
LEU A 548
 None
 1.11A 1igxA-5b3hA:
undetectable		 1igxA-5b3hA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 250
ALA A 106
SER A 110
GLY A 111
LEU A 112
 None
 1.10A 1igxA-5bp1A:
undetectable		 1igxA-5bp1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 PHE A 343
ALA A 482
SER A 486
GLY A 487
LEU A 412
 None
 1.11A 1igxA-5bs5A:
undetectable		 1igxA-5bs5A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8e METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF13847
(Methyltransf_31) 		5 LEU A 165
PHE A 198
ALA A 173
SER A 196
GLY A 194
 None
 1.08A 1igxA-5f8eA:
undetectable		 1igxA-5f8eA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH

(synthetic
construct) 		PF00753
(Lactamase_B) 		5 LEU A 147
GLY A 165
ALA A 168
GLY A 122
LEU A 123
 None
 1.10A 1igxA-5hifA:
undetectable		 1igxA-5hifA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 PHE A 205
PHE A 209
LEU A 352
TYR A 355
PHE A 381
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
GLY A 533
LEU A 534
 None
None
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
None
 0.59A 1igxA-5ikrA:
57.8		 1igxA-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU B 361
PHE B 581
GLY B 584
GLY B 588
LEU B 566
 None
 0.90A 1igxA-5ip9B:
undetectable		 1igxA-5ip9B:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		5 LEU A  26
PHE A  88
GLY A  75
GLY A 116
LEU A  42
 None
 1.13A 1igxA-5jzbA:
undetectable		 1igxA-5jzbA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		5 PHE A 164
PHE A 188
GLY A 151
ALA A 152
LEU A 173
 None
 0.98A 1igxA-5lq4A:
undetectable		 1igxA-5lq4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2y TSSK C

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		5 PHE A 345
PHE A 426
GLY A 369
GLY A 332
LEU A 334
 None
 1.12A 1igxA-5m2yA:
undetectable		 1igxA-5m2yA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 PHE A 425
LEU A 245
PHE A 264
TRP A 261
ALA A 470
 None
 1.00A 1igxA-5oltA:
undetectable		 1igxA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 5 GLY A 176
ALA A 177
SER A 180
GLY A 182
LEU A 184
 None
 1.03A 1igxA-5oonA:
undetectable		 1igxA-5oonA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 PHE A 378
TYR A 119
TYR A 403
GLY A 132
SER A 134
 None
 1.13A 1igxA-5t9gA:
undetectable		 1igxA-5t9gA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4n FRUCTOSE-1

(Neisseria
gonorrhoeae) 		PF01116
(F_bP_aldolase) 		5 PHE A 203
GLY A 155
ALA A 154
SER A 197
GLY A 233
 None
None
None
None
PO4  A 401 ( 3.2A)
 1.14A 1igxA-5u4nA:
0.3		 1igxA-5u4nA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 5 PHE A 415
LEU A 448
ALA A 462
GLY A 459
LEU A 451
 None
 1.13A 1igxA-5v2dA:
undetectable		 1igxA-5v2dA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		5 PHE A 210
TYR A 416
GLY A 193
ALA A 194
LEU A 201
 None
 1.13A 1igxA-5w1uA:
undetectable		 1igxA-5w1uA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5was HOMOSERINE KINASE

(Corynebacterium
glutamicum) 		no annotation 6 LEU C 273
GLY A  30
ALA A  20
SER A  19
GLY A 101
LEU A 100
 None
None
None
None
PO4  A 401 (-4.0A)
None
 1.46A 1igxA-5wasC:
undetectable		 1igxA-5wasC:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU B 354
PHE B 574
GLY B 577
GLY B 581
LEU B 559
 None
 1.11A 1igxA-5xogB:
undetectable		 1igxA-5xogB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Helicobacter
pylori) 		no annotation 5 PHE A  92
LEU A  97
GLY A   3
ALA A  52
GLY A  60
 None
 1.01A 1igxA-5xukA:
undetectable		 1igxA-5xukA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR

(Galdieria
sulphuraria) 		PF03151
(TPT) 		5 PHE A 272
GLY A 211
ALA A 212
SER A 215
LEU A 219
 OLC  A 507 (-4.8A)
None
None
None
None
 0.91A 1igxA-5y79A:
undetectable		 1igxA-5y79A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR

(Galdieria
sulphuraria) 		PF03151
(TPT) 		5 PHE A 272
GLY A 211
ALA A 212
SER A 215
LEU A 219
 OLC  A 507 (-4.8A)
None
None
None
None
 1.01A 1igxA-5y79A:
undetectable		 1igxA-5y79A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica) 		no annotation 5 TYR A  29
GLY A  47
ALA A  48
GLY A 113
LEU A  40
 None
 1.10A 1igxA-5yhpA:
undetectable		 1igxA-5yhpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoa T-FIMBRIN

(Homo sapiens) 		PF00307
(CH) 		5 VAL A 211
VAL A 165
SER A 203
ILE A 207
LEU A 230
 VAL  A 211 ( 0.6A)
VAL  A 165 ( 0.6A)
SER  A 203 ( 0.0A)
ILE  A 207 ( 0.7A)
LEU  A 230 ( 0.6A)
 1.34A 1igxA-1aoaA:
undetectable		 1igxA-1aoaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0u HISTIDINE PERMEASE

(Salmonella
enterica) 		PF00005
(ABC_tran) 		5 VAL A 174
VAL A 207
SER A  36
ILE A 224
LEU A  49
 None
 1.37A 1igxA-1b0uA:
0.0		 1igxA-1b0uA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)

(Escherichia
coli) 		PF02219
(MTHFR) 		4 ARG A  67
VAL A 136
ILE A  92
LEU A  89
 None
 0.90A 1igxA-1b5tA:
0.0		 1igxA-1b5tA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 VAL A 433
TYR A 255
VAL A 254
LEU A 435
 None
None
PC1  A 777 (-4.8A)
None
 0.82A 1igxA-1bp1A:
0.0		 1igxA-1bp1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 VAL A 251
TYR A 254
ILE A 263
LEU A 103
 None
 0.86A 1igxA-1bs0A:
0.0		 1igxA-1bs0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cee GTP-BINDING RHO-LIKE
PROTEIN

(Homo sapiens) 		PF00071
(Ras) 		5 VAL A  98
VAL A  93
SER A  89
ILE A 137
LEU A 112
 None
 1.35A 1igxA-1ceeA:
0.0		 1igxA-1ceeA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 VAL A   4
TYR A 261
VAL A 262
SER A 323
LEU A   7
 None
 0.98A 1igxA-1cg4A:
undetectable		 1igxA-1cg4A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A  91
VAL A  45
VAL A  47
LEU A  59
 None
 0.91A 1igxA-1civA:
0.0		 1igxA-1civA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmv HUMAN
CYTOMEGALOVIRUS
PROTEASE

(Human
betaherpesvirus
5) 		PF00716
(Peptidase_S21) 		4 VAL A 158
VAL A  14
VAL A  16
LEU A 160
 None
 0.84A 1igxA-1cmvA:
0.0		 1igxA-1cmvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 VAL A 261
VAL A 259
ILE A 167
LEU A 174
 None
 0.76A 1igxA-1d8cA:
0.7		 1igxA-1d8cA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 VAL A  56
VAL A 337
TYR A 391
LEU A 334
 None
 0.91A 1igxA-1d9zA:
undetectable		 1igxA-1d9zA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 VAL A 116
ARG A 120
VAL A 344
TYR A 348
VAL A 349
SER A 353
ILE A 523
LEU A 531
 None
SCL  A 700 (-3.9A)
None
None
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-3.4A)
OAS  A 530 (-4.1A)
 0.45A 1igxA-1ebvA:
61.2		 1igxA-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq9 CHYMOTRYPSIN

(Solenopsis
invicta) 		PF00089
(Trypsin) 		4 VAL A  59
VAL A  52
ILE A 212
LEU A  33
 None
 0.71A 1igxA-1eq9A:
undetectable		 1igxA-1eq9A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 VAL A 241
VAL A 316
VAL A 320
ILE A 234
 None
 0.92A 1igxA-1ex0A:
1.1		 1igxA-1ex0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f15 COAT PROTEIN

(Cucumber mosaic
virus) 		PF00760
(Cucumo_coat) 		4 TYR A  86
VAL A 187
ILE A 109
LEU A 199
 None
 0.91A 1igxA-1f15A:
undetectable		 1igxA-1f15A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL B 242
VAL B 246
SER B 250
ILE B 286
 None
 0.90A 1igxA-1ffvB:
0.7		 1igxA-1ffvB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fon PROCARBOXYPEPTIDASE
A-S6

(Bos taurus) 		PF00089
(Trypsin) 		4 VAL A  14
VAL A  97
ILE A  70
LEU A  16
 None
 0.85A 1igxA-1fonA:
undetectable		 1igxA-1fonA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 VAL A 374
VAL A 358
TYR A 236
VAL A 362
 None
 0.87A 1igxA-1gytA:
0.0		 1igxA-1gytA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE

(Escherichia
coli) 		PF01634
(HisG)
PF08029
(HisG_C) 		4 VAL A  66
ARG A   8
VAL A  53
ILE A  40
 None
 0.83A 1igxA-1h3dA:
undetectable		 1igxA-1h3dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hgx HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Tritrichomonas
suis) 		PF00156
(Pribosyltran) 		4 VAL A 143
VAL A  98
VAL A 100
LEU A 115
 None
 0.84A 1igxA-1hgxA:
undetectable		 1igxA-1hgxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		4 VAL A 116
VAL A 212
ILE A  29
LEU A 119
 None
 0.90A 1igxA-1hkhA:
undetectable		 1igxA-1hkhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1is7 GTP CYCLOHYDROLASE I

(Rattus
norvegicus) 		PF01227
(GTP_cyclohydroI) 		4 VAL A 163
VAL A 121
VAL A 123
LEU A 159
 None
 0.81A 1igxA-1is7A:
undetectable		 1igxA-1is7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 TYR A 870
VAL A 871
SER A 875
ILE A1056
 None
 0.87A 1igxA-1k32A:
undetectable		 1igxA-1k32A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI

(Pantoea
stewartii) 		PF00765
(Autoind_synth) 		5 VAL A  64
VAL A 190
VAL A 121
ILE A  55
LEU A   2
 None
 1.34A 1igxA-1k4jA:
undetectable		 1igxA-1k4jA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		4 VAL A  29
SER A  54
ILE A 131
LEU A 117
 None
 0.89A 1igxA-1kfwA:
undetectable		 1igxA-1kfwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 VAL A 246
VAL A 248
ILE A 338
LEU A 343
 None
 0.78A 1igxA-1lamA:
0.0		 1igxA-1lamA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 VAL A 528
VAL A 482
VAL A 484
LEU A 533
 None
 0.85A 1igxA-1lq2A:
undetectable		 1igxA-1lq2A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		4 VAL A 199
VAL A 195
SER A 191
LEU A 221
 None
 0.84A 1igxA-1lujA:
undetectable		 1igxA-1lujA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6j TRIOSEPHOSPHATE
ISOMERASE

(Entamoeba
histolytica) 		PF00121
(TIM) 		4 VAL A  42
VAL A  44
ILE A  21
LEU A  58
 None
 0.82A 1igxA-1m6jA:
undetectable		 1igxA-1m6jA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		4 TYR A 217
VAL A 246
SER A 279
ILE A 269
 None
 0.89A 1igxA-1m7jA:
undetectable		 1igxA-1m7jA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		4 VAL A 220
TYR A 250
ILE A 106
LEU A 223
 None
 0.91A 1igxA-1nj8A:
undetectable		 1igxA-1nj8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnl L-3-PHOSPHOSERINE
PHOSPHATASE

(Homo sapiens) 		PF00702
(Hydrolase) 		4 VAL A 105
VAL A  25
ILE A 177
LEU A 107
 None
 0.88A 1igxA-1nnlA:
undetectable		 1igxA-1nnlA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nww LIMONENE-1,2-EPOXIDE
HYDROLASE

(Rhodococcus
erythropolis) 		PF07858
(LEH) 		4 VAL A 119
TYR A  96
VAL A  95
LEU A 122
 None
 0.89A 1igxA-1nwwA:
undetectable		 1igxA-1nwwA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 VAL A  82
VAL A  33
VAL A  35
ILE A 394
LEU A 294
 None
 1.49A 1igxA-1odoA:
undetectable		 1igxA-1odoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 5 VAL A 116
VAL A   9
VAL A  94
ILE A 139
LEU A 104
 None
 1.27A 1igxA-1oy1A:
undetectable		 1igxA-1oy1A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 VAL A 146
VAL A 299
ILE A 216
LEU A 175
 None
 0.92A 1igxA-1pgsA:
undetectable		 1igxA-1pgsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		4 VAL A 353
SER A 337
ILE A 440
LEU A 355
 None
 0.79A 1igxA-1pjqA:
undetectable		 1igxA-1pjqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR

(Homo sapiens) 		PF00386
(C1q) 		4 VAL C 159
VAL C 161
ILE B 214
LEU C 181
 None
 0.89A 1igxA-1pk6C:
undetectable		 1igxA-1pk6C:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		4 VAL A  29
VAL A  98
SER A 121
LEU A  88
 None
 0.83A 1igxA-1q0zA:
undetectable		 1igxA-1q0zA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9c SON OF SEVENLESS
PROTEIN

(Homo sapiens) 		PF00125
(Histone) 		5 VAL A  30
TYR A  47
VAL A  48
ILE A 137
LEU A 142
 None
 1.09A 1igxA-1q9cA:
1.0		 1igxA-1q9cA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 VAL X 662
VAL X 731
VAL X 733
LEU X 712
 None
 0.91A 1igxA-1r6bX:
0.8		 1igxA-1r6bX:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shx EPHRIN-A5

(Mus musculus) 		PF00812
(Ephrin) 		4 VAL A  38
VAL A 163
VAL A 161
LEU A  62
 None
 0.90A 1igxA-1shxA:
undetectable		 1igxA-1shxA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 VAL A 130
VAL A 149
ILE A 220
LEU A 132
 None
 0.92A 1igxA-1suwA:
undetectable		 1igxA-1suwA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		4 VAL A  15
VAL A 151
VAL A 153
ILE A 166
 FMN  A 200 (-4.1A)
None
None
None
 0.69A 1igxA-1t0iA:
undetectable		 1igxA-1t0iA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t70 PHOSPHATASE

(Deinococcus
radiodurans) 		PF13277
(YmdB) 		4 ARG A  26
VAL A   9
VAL A  34
LEU A  22
 None
 0.91A 1igxA-1t70A:
undetectable		 1igxA-1t70A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE

(Mycobacterium
bovis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		5 VAL A 194
VAL A 251
VAL A 233
SER A 200
LEU A 208
 None
 1.48A 1igxA-1tdtA:
undetectable		 1igxA-1tdtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Homo sapiens) 		PF00574
(CLP_protease) 		4 VAL A  39
VAL A  43
ILE A  59
LEU A 102
 None
 0.88A 1igxA-1tg6A:
undetectable		 1igxA-1tg6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 VAL A  14
VAL A 164
VAL A 162
ILE A 229
LEU A  11
 None
 1.12A 1igxA-1udqA:
undetectable		 1igxA-1udqA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uen KIAA0343 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		4 VAL A  97
VAL A  25
VAL A  23
LEU A  95
 None
 0.88A 1igxA-1uenA:
undetectable		 1igxA-1uenA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugs NITRILE HYDRATASE
ALPHA SUBUNIT

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		4 VAL A 151
ARG A 140
VAL A 107
VAL A 159
 None
 0.88A 1igxA-1ugsA:
undetectable		 1igxA-1ugsA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upn ECHOVIRUS 11 COAT
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		4 VAL C  55
VAL C  53
SER C  51
LEU C 116
 None
 0.91A 1igxA-1upnC:
undetectable		 1igxA-1upnC:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqx LECTIN

(Ralstonia
solanacearum) 		PF07472
(PA-IIL) 		4 VAL A  91
VAL A  32
VAL A  30
LEU A 108
 None
 0.91A 1igxA-1uqxA:
undetectable		 1igxA-1uqxA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A  89
VAL A  91
SER A  93
ILE A  11
LEU A  19
 None
None
None
NAD  A 336 (-4.3A)
None
 1.32A 1igxA-1vc2A:
undetectable		 1igxA-1vc2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		5 VAL A 124
VAL A  64
VAL A  66
ILE A  68
LEU A  97
 None
None
None
SAM  A 302 (-3.7A)
None
 0.96A 1igxA-1ve3A:
undetectable		 1igxA-1ve3A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		4 VAL A  52
VAL A   1
SER A 171
ILE A 183
 None
 0.89A 1igxA-1wczA:
undetectable		 1igxA-1wczA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf0 TAR DNA-BINDING
PROTEIN-43

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL A   8
VAL A  10
ILE A  68
LEU A  22
 None
 0.85A 1igxA-1wf0A:
undetectable		 1igxA-1wf0A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 VAL A  93
VAL A  91
ILE A  57
LEU A 163
 None
 0.85A 1igxA-1wf3A:
undetectable		 1igxA-1wf3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlc CONGERIN II

(Conger
myriaster) 		PF00337
(Gal-bind_lectin) 		4 VAL A  19
VAL A  34
ILE A  99
LEU A  17
 None
 0.86A 1igxA-1wlcA:
undetectable		 1igxA-1wlcA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjv PROTECTION OF
TELOMERES 1

(Homo sapiens) 		PF02765
(POT1)
PF16686
(POT1PC) 		5 ARG A 276
VAL A  28
VAL A  79
SER A 103
ILE A  71
 None
 1.45A 1igxA-1xjvA:
undetectable		 1igxA-1xjvA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xln PUTIDAREDOXIN

(Pseudomonas
putida) 		PF00111
(Fer2) 		5 VAL A  17
VAL A  52
VAL A  99
ILE A  32
LEU A  23
 None
 1.22A 1igxA-1xlnA:
undetectable		 1igxA-1xlnA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 VAL A  87
VAL A  62
VAL A  60
LEU A  91
 None
 0.91A 1igxA-1xzqA:
undetectable		 1igxA-1xzqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y07 DESULFOFERRODOXIN
(RBO)

(Treponema
pallidum) 		PF01880
(Desulfoferrodox) 		4 VAL A  81
VAL A  56
VAL A  54
LEU A  83
 None
FE  A 503 ( 4.9A)
None
None
 0.92A 1igxA-1y07A:
undetectable		 1igxA-1y07A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yby TRANSLATION
ELONGATION FACTOR P

(Ruminiclostridium
thermocellum) 		PF01132
(EFP)
PF08207
(EFP_N)
PF09285
(Elong-fact-P_C) 		4 VAL A 111
VAL A 113
SER A 115
LEU A  93
 None
 0.92A 1igxA-1ybyA:
undetectable		 1igxA-1ybyA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf9 UBIQUITIN CARRIER
PROTEIN 4

(Leishmania
major) 		PF00179
(UQ_con) 		5 VAL A  42
VAL A  61
SER A  73
ILE A  97
LEU A 107
 None
 1.08A 1igxA-1yf9A:
undetectable		 1igxA-1yf9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		4 VAL A 158
VAL A 189
VAL A 191
ILE A  95
 GOL  A 702 ( 4.2A)
None
None
None
 0.88A 1igxA-1yjkA:
undetectable		 1igxA-1yjkA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Bacillus
subtilis) 		PF02547
(Queuosine_synth) 		5 VAL A 242
ARG A 243
VAL A  57
ILE A 291
LEU A 239
 None
 1.20A 1igxA-1yy3A:
undetectable		 1igxA-1yy3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 VAL A 130
VAL A 149
ILE A 220
LEU A 132
 None
 0.91A 1igxA-1z0uA:
undetectable		 1igxA-1z0uA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1znx GUANYLATE KINASE

(Mycobacterium
tuberculosis) 		PF00625
(Guanylate_kin) 		4 VAL A  37
VAL A 136
VAL A 138
LEU A 196
 None
 0.81A 1igxA-1znxA:
undetectable		 1igxA-1znxA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		4 VAL A 167
VAL A 165
SER A 163
ILE A 135
 None
 0.89A 1igxA-1ztvA:
undetectable		 1igxA-1ztvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ah5 COG0546: PREDICTED
PHOSPHATASES

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		4 VAL A 205
TYR A 103
ILE A   4
LEU A  96
 None
 0.92A 1igxA-2ah5A:
undetectable		 1igxA-2ah5A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 ARG A 270
VAL A 324
VAL A 322
LEU A 272
 None
 0.86A 1igxA-2b5mA:
undetectable		 1igxA-2b5mA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bu2 PYRUVATE
DEHYDROGENSAE KINASE
ISOENZYME 2

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 VAL A  73
TYR A 145
ILE A  56
LEU A  63
 None
 0.83A 1igxA-2bu2A:
undetectable		 1igxA-2bu2A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cub CYTOPLASMIC PROTEIN
NCK1

(Homo sapiens) 		PF14604
(SH3_9) 		4 VAL A  44
VAL A  42
ILE A  37
LEU A  34
 None
 0.85A 1igxA-2cubA:
undetectable		 1igxA-2cubA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 VAL A 197
TYR A 165
SER A 171
ILE A 173
LEU A 193
 None
 1.16A 1igxA-2cyaA:
undetectable		 1igxA-2cyaA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		5 ARG A  48
VAL A 536
VAL A 440
SER A 474
LEU A 517
 None
 1.13A 1igxA-2du7A:
0.6		 1igxA-2du7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e21 TRNA(ILE)-LYSIDINE
SYNTHASE

(Aquifex
aeolicus) 		PF01171
(ATP_bind_3) 		4 VAL A  35
VAL A  39
ILE A   8
LEU A 169
 None
 0.89A 1igxA-2e21A:
undetectable		 1igxA-2e21A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 VAL A  87
VAL A  65
ILE A  57
LEU A  89
 None
 0.91A 1igxA-2eidA:
undetectable		 1igxA-2eidA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 VAL A 268
VAL A 250
VAL A 255
ILE A 264
LEU A   9
 None
 1.39A 1igxA-2ftpA:
undetectable		 1igxA-2ftpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 VAL A  53
TYR A 107
SER A 160
ILE A 294
 None
STU  A 400 (-4.5A)
None
None
 0.88A 1igxA-2gcdA:
undetectable		 1igxA-2gcdA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqt UDP-N-ACETYLENOLPYRU
VYLGLUCOSAMINE
REDUCTASE

(Thermus
caldophilus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 VAL A 183
ARG A 187
VAL A  87
ILE A 104
 None
FAD  A 601 (-2.7A)
None
FAD  A 601 (-4.1A)
 0.91A 1igxA-2gqtA:
undetectable		 1igxA-2gqtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		4 VAL A 115
VAL A  61
VAL A  63
LEU A  90
 None
 0.66A 1igxA-2gs9A:
undetectable		 1igxA-2gs9A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A 335
VAL A  65
VAL A   5
ILE A  19
LEU A  69
 None
 1.38A 1igxA-2gz3A:
undetectable		 1igxA-2gz3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha9 UPF0210 PROTEIN
SP0239

(Streptococcus
pneumoniae) 		PF05167
(DUF711) 		5 VAL A 118
VAL A 395
VAL A 184
SER A 146
ILE A 133
 None
 1.40A 1igxA-2ha9A:
undetectable		 1igxA-2ha9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ARG A  36
VAL A  12
ILE A  67
LEU A  35
 None
 0.89A 1igxA-2ho4A:
undetectable		 1igxA-2ho4A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN

(Mycoplasma
arthritidis) 		PF09245
(MA-Mit) 		4 VAL G  52
VAL G  86
ILE G 100
LEU G 107
 None
 0.89A 1igxA-2icwG:
undetectable		 1igxA-2icwG:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		4 VAL A 373
VAL A 391
ILE A 273
LEU A 369
 None
 0.90A 1igxA-2iluA:
undetectable		 1igxA-2iluA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		4 VAL G 246
VAL G 296
ILE G 360
LEU G 305
 None
 0.91A 1igxA-2iouG:
undetectable		 1igxA-2iouG:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Escherichia
coli) 		PF00692
(dUTPase) 		4 VAL A 120
VAL A  33
VAL A  35
LEU A 107
 None
 0.63A 1igxA-2j4hA:
undetectable		 1igxA-2j4hA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jax HYPOTHETICAL PROTEIN
TB31.7

(Mycobacterium
tuberculosis) 		PF00582
(Usp) 		4 VAL A  91
VAL A  24
ILE A  10
LEU A  40
 None
 0.86A 1igxA-2jaxA:
undetectable		 1igxA-2jaxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jks BRADYZOITE SURFACE
ANTIGEN BSR4

(Toxoplasma
gondii) 		PF04092
(SAG) 		4 VAL A 174
VAL A 307
VAL A 305
LEU A 198
 None
 0.78A 1igxA-2jksA:
undetectable		 1igxA-2jksA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2js0 CYTOPLASMIC PROTEIN
NCK1

(Homo sapiens) 		PF14604
(SH3_9) 		4 VAL A  31
VAL A  29
ILE A  24
LEU A  21
 None
 0.90A 1igxA-2js0A:
undetectable		 1igxA-2js0A:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k75 UNCHARACTERIZED
PROTEIN TA0387

(Thermoplasma
acidophilum) 		no annotation 5 VAL A  84
VAL A   4
VAL A  18
ILE A  22
LEU A  82
 None
 1.38A 1igxA-2k75A:
undetectable		 1igxA-2k75A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7q FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		4 VAL A2030
VAL A2007
ILE A2009
LEU A1983
 None
 0.88A 1igxA-2k7qA:
undetectable		 1igxA-2k7qA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4q THIOREDOXIN

(Mycobacterium
tuberculosis) 		PF00085
(Thioredoxin) 		4 VAL A 111
VAL A  21
ILE A  50
LEU A  85
 None
 0.86A 1igxA-2l4qA:
undetectable		 1igxA-2l4qA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8j GAMMA-AMINOBUTYRIC
ACID
RECEPTOR-ASSOCIATED
PROTEIN-LIKE 1

(Homo sapiens) 		PF02991
(Atg8) 		5 VAL A  57
TYR A 106
VAL A 107
ILE A  84
LEU A  94
 None
 1.50A 1igxA-2l8jA:
undetectable		 1igxA-2l8jA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqn CRK-LIKE PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07653
(SH3_2) 		4 ARG A  57
VAL A 170
SER A 162
ILE A 152
 None
 0.86A 1igxA-2lqnA:
undetectable		 1igxA-2lqnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01933
(UPF0052) 		4 VAL A  60
VAL A   6
VAL A   8
LEU A  19
 None
 0.87A 1igxA-2o2zA:
undetectable		 1igxA-2o2zA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 INTERCELLULAR
ADHESION MOLECULE 1

(Homo sapiens) 		no annotation 4 VAL A 295
VAL A 288
VAL A 303
LEU A 363
 None
 0.87A 1igxA-2oz4A:
undetectable		 1igxA-2oz4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz6 VIRULENCE FACTOR
REGULATOR

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		4 VAL A 201
VAL A 144
VAL A 148
ILE A 172
 None
 0.81A 1igxA-2oz6A:
undetectable		 1igxA-2oz6A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz6 VIRULENCE FACTOR
REGULATOR

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		5 VAL A 210
VAL A 144
VAL A 148
ILE A 172
LEU A 195
 None
 1.50A 1igxA-2oz6A:
undetectable		 1igxA-2oz6A:
16.38