SIMILAR PATTERNS OF AMINO ACIDS FOR 1IGJ_B_DGXB228

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
LIGHT CHAIN (VL) OF
FV-FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 TYR K  36
TYR J  34
ASN J  36
SER J  99
MET J 109
 None
 0.84A 1igjA-1kyoK:
20.0
1igjB-1kyoK:
14.4		 1igjA-1kyoK:
56.25
1igjB-1kyoK:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
LIGHT CHAIN (VL) OF
FV-FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 TYR K  36
TYR J  34
ASN J  36
TYR J  51
MET J 109
 None
 0.78A 1igjA-1kyoK:
20.0
1igjB-1kyoK:
14.4		 1igjA-1kyoK:
56.25
1igjB-1kyoK:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF01823
(MACPF) 		5 TYR A 311
THR A 441
TYR A 142
ASN A 181
TYR A 180
 None
 1.25A 1igjA-2qqhA:
0.0
1igjB-2qqhA:
0.0		 1igjA-2qqhA:
19.22
1igjB-2qqhA:
18.29