SIMILAR PATTERNS OF AMINO ACIDS FOR 1IEP_B_STIB202_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 VAL A 240
VAL A 232
ILE A 283
LEU A 246
 None
 0.86A 1iepB-1bs0A:
undetectable		 1iepB-1bs0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0k DNA HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C) 		4 VAL A 459
VAL A 310
ILE A 422
LEU A 502
 None
 0.92A 1iepB-1e0kA:
undetectable		 1iepB-1e0kA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 ILE A 264
MET A 269
ARG A 313
LEU A 321
 None
 0.67A 1iepB-1k9aA:
27.0		 1iepB-1k9aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 249
ILE A 264
ARG A 313
 None
 0.87A 1iepB-1k9aA:
27.0		 1iepB-1k9aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 239
VAL A 249
ILE A 264
ARG A 313
LEU A 321
 None
 0.73A 1iepB-1k9aA:
27.0		 1iepB-1k9aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LYS A 290
VAL A 308
VAL A 318
ILE A 332
MET A 337
LEU A 389
 P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
P16  A   2 (-4.4A)
 0.65A 1iepB-1opkA:
34.7		 1iepB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 318
ILE A 332
MET A 337
ARG A 381
 P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
None
 0.94A 1iepB-1opkA:
34.7		 1iepB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 643
VAL A 654
ARG A 791
LEU A 799
 None
STI  A   3 (-4.3A)
None
STI  A   3 (-4.4A)
 0.65A 1iepB-1t46A:
34.4		 1iepB-1t46A:
36.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 LYS A  32
VAL A  63
ARG A 124
LEU A 132
 None
 0.90A 1iepB-1v0bA:
21.8		 1iepB-1v0bA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 VAL A 195
VAL A  53
ILE A 170
LEU A  57
 FAD  A 501 (-3.8A)
None
None
None
 1.02A 1iepB-1zr6A:
undetectable		 1iepB-1zr6A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN

(Thermus
aquaticus) 		no annotation 4 VAL D 300
VAL D 259
ARG D 224
LEU D 261
 None
 0.91A 1iepB-2aujD:
undetectable		 1iepB-2aujD:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE X  80
MET X  85
ARG X 129
LEU X 137
 None
None
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
 0.83A 1iepB-2dq7X:
32.4		 1iepB-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL X  67
ILE X  80
ARG X 129
LEU X 137
 None
None
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
 0.93A 1iepB-2dq7X:
32.4		 1iepB-2dq7X:
44.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 204
VAL A 220
ILE A 234
LEU A 290
 None
 0.67A 1iepB-2eu9A:
21.6		 1iepB-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 VAL A 518
VAL A 527
ILE A 350
LEU A 532
 None
 0.94A 1iepB-2fj0A:
undetectable		 1iepB-2fj0A:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 295
VAL A 323
ILE A 336
MET A 341
 None
 0.64A 1iepB-2hckA:
29.9		 1iepB-2hckA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 VAL A 226
VAL A 145
ARG A 118
LEU A 188
 None
 0.97A 1iepB-2hg4A:
undetectable		 1iepB-2hg4A:
15.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 289
VAL A 299
ILE A 313
MET A 318
LEU A 370
 None
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
GIN  A 600 (-4.7A)
 0.45A 1iepB-2hz0A:
34.9		 1iepB-2hz0A:
97.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 299
ILE A 313
MET A 318
ARG A 362
LEU A 370
 GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
None
GIN  A 600 (-4.7A)
 0.71A 1iepB-2hz0A:
34.9		 1iepB-2hz0A:
97.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		4 VAL A 569
VAL A 610
ILE A 624
LEU A 601
 None
 0.90A 1iepB-2id0A:
undetectable		 1iepB-2id0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 LYS A 454
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 (-3.4A)
None
None
4ST  A1687 (-4.4A)
 0.66A 1iepB-2j0jA:
32.1		 1iepB-2j0jA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 301
ILE A 314
MET A 319
LEU A 371
 None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 4.3A)
 0.59A 1iepB-2og8A:
27.0		 1iepB-2og8A:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 301
MET A 319
ARG A 363
LEU A 371
 None
1N8  A 501 ( 4.4A)
None
1N8  A 501 ( 4.3A)
 0.70A 1iepB-2og8A:
27.0		 1iepB-2og8A:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		4 VAL B  98
MET B 117
ARG B 163
LEU B 171
 None
None
TPO  B 199 ( 3.5A)
None
 0.72A 1iepB-2qkwB:
23.0		 1iepB-2qkwB:
29.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 781
MET A 799
ARG A 842
LEU A 850
 GW7  A   1 ( 4.7A)
None
None
GW7  A   1 (-4.2A)
 0.57A 1iepB-2r4bA:
28.9		 1iepB-2r4bA:
36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		4 VAL A 320
ILE A 309
ARG A 351
LEU A 317
 None
 0.91A 1iepB-2vf8A:
undetectable		 1iepB-2vf8A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL B 121
VAL B 131
MET B 150
ARG B 194
LEU B 202
 None
None
None
None
ANP  B 432 ( 4.7A)
 0.76A 1iepB-2wtkB:
22.5		 1iepB-2wtkB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 VAL A 121
VAL A  26
ILE A  47
LEU A 286
 None
 0.88A 1iepB-2wzsA:
undetectable		 1iepB-2wzsA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  49
ILE A  93
ARG A 139
LEU A 147
 None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
 0.73A 1iepB-2xikA:
19.0		 1iepB-2xikA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xiv HYPOTHETICAL
INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 VAL A 387
ILE A 423
ARG A 340
LEU A 398
 None
 0.67A 1iepB-2xivA:
undetectable		 1iepB-2xivA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 264
MET A 269
ARG A 313
LEU A 321
 None
 0.67A 1iepB-3d7uA:
27.0		 1iepB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 249
ILE A 264
ARG A 313
 None
 0.87A 1iepB-3d7uA:
27.0		 1iepB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 239
VAL A 249
ILE A 264
ARG A 313
LEU A 321
 None
 0.73A 1iepB-3d7uA:
27.0		 1iepB-3d7uA:
44.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A  53
VAL A  14
ARG A 119
LEU A  12
 None
 0.91A 1iepB-3dh9A:
undetectable		 1iepB-3dh9A:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 LYS A 665
VAL A 695
ILE A 709
MET A 714
LEU A 765
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 (-4.6A)
 0.71A 1iepB-3dkoA:
30.8		 1iepB-3dkoA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		4 VAL A  48
VAL A 184
ILE A  28
LEU A 156
 None
 0.81A 1iepB-3e7dA:
undetectable		 1iepB-3e7dA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  82
ILE A 127
MET A 132
LEU A 186
 STU  A   1 ( 4.2A)
None
None
STU  A   1 (-4.4A)
 0.73A 1iepB-3fmeA:
17.6		 1iepB-3fmeA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  82
VAL A 113
ILE A 127
LEU A 186
 STU  A   1 ( 4.2A)
None
None
STU  A   1 (-4.4A)
 0.76A 1iepB-3fmeA:
17.6		 1iepB-3fmeA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE

(Staphylococcus
aureus) 		PF00912
(Transgly) 		4 VAL A 242
ILE A 231
MET A 264
LEU A 246
 None
 0.93A 1iepB-3hzsA:
undetectable		 1iepB-3hzsA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 VAL A 221
VAL A 182
ILE A 200
LEU A 190
 None
NAE  A 311 (-4.6A)
None
None
 0.98A 1iepB-3i3oA:
undetectable		 1iepB-3i3oA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 VAL A 326
VAL A 392
ILE A 366
LEU A 397
 None
 0.84A 1iepB-3ialA:
undetectable		 1iepB-3ialA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kje CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE
COMPLEX, ACCESSORY
PROTEIN COOC

(Carboxydothermus
hydrogenoformans) 		PF01656
(CbiA) 		4 VAL A 193
VAL A  16
ILE A 161
LEU A  20
 None
 0.99A 1iepB-3kjeA:
undetectable		 1iepB-3kjeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl2 PUTATIVE
ISOCHORISMATASE

(Streptomyces
avermitilis) 		PF00857
(Isochorismatase) 		4 VAL A  46
ILE A 162
ARG A 149
LEU A 173
 None
 1.00A 1iepB-3kl2A:
undetectable		 1iepB-3kl2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		4 VAL A 199
ILE A 181
ARG A   3
LEU A 195
 None
 0.97A 1iepB-3ks5A:
undetectable		 1iepB-3ks5A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)

(Cupriavidus
metallidurans) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		4 VAL A 208
VAL A 182
ARG A 269
LEU A  75
 None
 0.97A 1iepB-3lnnA:
2.2		 1iepB-3lnnA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		4 VAL A 372
VAL A 383
ILE A 402
LEU A 387
 None
 1.00A 1iepB-3lovA:
undetectable		 1iepB-3lovA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqk DIPICOLINATE
SYNTHASE SUBUNIT B

(Bacillus
halodurans) 		PF02441
(Flavoprotein) 		4 VAL A  70
ILE A  61
MET A 171
LEU A 174
 None
 0.87A 1iepB-3lqkA:
undetectable		 1iepB-3lqkA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 VAL A  82
MET A 101
ARG A 143
LEU A 151
 None
None
None
ADP  A 314 (-4.6A)
 0.90A 1iepB-3nizA:
22.7		 1iepB-3nizA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 247
MET A 266
ARG A 310
LEU A 318
 None
None
None
AMP  A 577 (-4.8A)
 0.78A 1iepB-3nyoA:
21.3		 1iepB-3nyoA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzt GLUTAMATE--CYSTEINE
LIGASE

(Francisella
tularensis) 		PF04262
(Glu_cys_ligase) 		4 VAL A 447
VAL A  20
ILE A 440
LEU A  26
 None
 0.93A 1iepB-3nztA:
undetectable		 1iepB-3nztA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		4 VAL A 130
VAL A  82
ILE A 109
LEU A 160
 None
 1.02A 1iepB-3oajA:
undetectable		 1iepB-3oajA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LYS A  40
VAL A  72
MET A  93
LEU A 141
 None
 0.83A 1iepB-3oz6A:
21.0		 1iepB-3oz6A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q35 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 VAL B 121
ILE B  83
ARG B 184
LEU B 203
 None
 0.89A 1iepB-3q35B:
undetectable		 1iepB-3q35B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LYS A  73
VAL A  98
ILE A 116
ARG A 165
LEU A 173
 I85  A 350 (-2.8A)
None
None
None
None
 1.11A 1iepB-3sheA:
18.3		 1iepB-3sheA:
24.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 572
VAL A 601
MET A 620
LEU A 686
 0F4  A 902 (-4.0A)
None
None
0F4  A 902 (-4.5A)
 0.67A 1iepB-3v5qA:
33.2		 1iepB-3v5qA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 868
VAL A 899
ARG A1027
LEU A1035
 None
None
None
4TT  A2001 (-4.8A)
 0.89A 1iepB-3vidA:
30.4		 1iepB-3vidA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 113
MET A 132
ARG A 178
LEU A 186
 None
None
None
ANK  A 401 ( 4.9A)
 0.85A 1iepB-3vn9A:
21.7		 1iepB-3vn9A:
26.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 868
VAL A 899
ARG A1027
LEU A1035
 None
None
None
LEV  A1201 (-4.8A)
 1.00A 1iepB-3wzdA:
31.4		 1iepB-3wzdA:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  65
VAL A  94
ILE A 108
LEU A 164
 XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
 0.59A 1iepB-4bc6A:
21.7		 1iepB-4bc6A:
28.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 655
MET A 704
ARG A 765
LEU A 773
 DI1  A1000 (-3.9A)
None
None
DI1  A1000 (-4.5A)
 0.92A 1iepB-4ckrA:
32.7		 1iepB-4ckrA:
37.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LYS A  40
ILE A  86
ARG A 133
LEU A 141
 None
 0.97A 1iepB-4d28A:
12.8		 1iepB-4d28A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LYS A  40
VAL A  72
ARG A 133
LEU A 141
 None
 0.91A 1iepB-4d28A:
12.8		 1iepB-4d28A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  43
VAL A  77
ARG A 144
LEU A 152
 0RS  A 900 (-3.3A)
0RS  A 900 (-4.4A)
None
0RS  A 900 (-4.3A)
 0.96A 1iepB-4ez5A:
22.3		 1iepB-4ez5A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  52
VAL A  84
ARG A 145
LEU A 153
 None
None
None
STU  A 401 (-4.7A)
 0.92A 1iepB-4fr4A:
21.0		 1iepB-4fr4A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itm TETRAACYLDISACCHARID
E 4'-KINASE

(Aquifex
aeolicus) 		PF02606
(LpxK) 		4 VAL A 134
VAL A  41
ILE A  69
LEU A 154
 None
 0.96A 1iepB-4itmA:
undetectable		 1iepB-4itmA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 247
MET A 266
ARG A 310
LEU A 318
 None
None
None
SGV  A 601 (-4.9A)
 0.97A 1iepB-4tnbA:
17.3		 1iepB-4tnbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		4 VAL C 717
VAL C 709
ILE C 560
LEU C 703
 None
 0.81A 1iepB-4u1cC:
undetectable		 1iepB-4u1cC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3C

(Lachancea
kluyveri) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 VAL c 717
VAL c 709
ILE c 560
LEU c 703
 None
 0.82A 1iepB-4uerc:
2.4		 1iepB-4uerc:
16.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 VAL A  65
ILE A  79
MET A  84
LEU A 136
 None
None
None
ACP  A1264 ( 4.8A)
 0.62A 1iepB-4ueuA:
32.9		 1iepB-4ueuA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		4 LYS A 191
MET A 210
ARG A 347
LEU A 268
 None
 0.93A 1iepB-4uvkA:
undetectable		 1iepB-4uvkA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 248
MET A 267
ARG A 313
LEU A 321
 None
None
None
ANW  A 601 (-4.9A)
 0.75A 1iepB-4wboA:
22.0		 1iepB-4wboA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 VAL A 217
VAL A 131
ARG A 105
LEU A 179
 None
 0.93A 1iepB-4wkyA:
undetectable		 1iepB-4wkyA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 104
ILE A 124
ARG A 175
LEU A 183
 None
None
None
KSA  A 405 (-4.6A)
 0.74A 1iepB-4wsqA:
22.6		 1iepB-4wsqA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LYS B 290
VAL B 308
VAL B 318
ILE B 332
 1N1  B 601 (-4.6A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
 0.53A 1iepB-4xeyB:
29.0		 1iepB-4xeyB:
71.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 VAL B 308
ILE B 332
MET B 337
LEU B 389
 None
1N1  B 601 (-4.1A)
None
1N1  B 601 (-4.3A)
 0.62A 1iepB-4xeyB:
29.0		 1iepB-4xeyB:
71.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 VAL B 308
VAL B 318
ILE B 332
LEU B 389
 None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-4.3A)
 0.66A 1iepB-4xeyB:
29.0		 1iepB-4xeyB:
71.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 VAL A 754
VAL A 675
ARG A 645
LEU A 716
 None
 0.90A 1iepB-4zdnA:
undetectable		 1iepB-4zdnA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		4 VAL A 443
ILE A 477
ARG A 371
LEU A 566
 None
None
HMC  A 606 ( 3.7A)
None
 0.96A 1iepB-5csuA:
undetectable		 1iepB-5csuA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 VAL A 668
VAL A 672
ILE A 694
LEU A 649
 None
 0.88A 1iepB-5dmyA:
undetectable		 1iepB-5dmyA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 VAL A 420
VAL A 329
ILE A 415
LEU A 333
 None
 0.92A 1iepB-5gweA:
undetectable		 1iepB-5gweA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikn DNA PRIMASE/HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C)
PF13155
(Toprim_2) 		4 VAL D 459
VAL D 310
ILE D 422
LEU D 502
 None
 0.87A 1iepB-5iknD:
undetectable		 1iepB-5iknD:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  45
VAL A  74
ILE A  88
LEU A 143
 6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.7A)
 0.65A 1iepB-5j5tA:
21.3		 1iepB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 318
VAL A 328
ARG A 388
LEU A 396
 None
None
None
IPW  A 601 (-4.5A)
 0.92A 1iepB-5kbrA:
17.2		 1iepB-5kbrA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A 940
MET A 959
ARG A1008
LEU A1016
 None
None
None
ATP  A1200 (-4.6A)
 0.86A 1iepB-5lpyA:
22.7		 1iepB-5lpyA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A 940
MET A 959
ARG A1008
LEU A1016
 None
None
None
ADP  A1200 (-4.7A)
 0.87A 1iepB-5lpzA:
22.6		 1iepB-5lpzA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1u CURLI PRODUCTION
ASSEMBLY/TRANSPORT
COMPONENT CSGF

(Escherichia
coli) 		no annotation 4 VAL A  98
VAL A 111
ILE A  87
LEU A 114
 None
 0.97A 1iepB-5m1uA:
undetectable		 1iepB-5m1uA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 VAL A 128
VAL A 197
ILE A 160
LEU A  84
 None
 0.84A 1iepB-5t98A:
undetectable		 1iepB-5t98A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 LYS A  40
VAL A  72
ILE A  90
ARG A 137
 G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 1.01A 1iepB-5u94A:
18.9		 1iepB-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 255
MET A 274
ARG A 316
LEU A 324
 None
MES  A 604 (-3.9A)
None
None
 0.88A 1iepB-5uuuA:
21.1		 1iepB-5uuuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux2 ALDEHYDE
DECARBONYLASE

(Synechococcus
sp. RS9917) 		no annotation 4 VAL A  21
ILE A 185
MET A 174
LEU A  80
 None
 0.96A 1iepB-5ux2A:
undetectable		 1iepB-5ux2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 4 VAL A 738
ILE A 752
ARG A 802
LEU A 810
 9E1  A1001 (-4.1A)
None
None
9E1  A1001 (-4.5A)
 0.79A 1iepB-5vilA:
19.0		 1iepB-5vilA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vug UNCHARACTERIZED
PROTEIN RV2277C

(Mycobacterium
tuberculosis) 		PF03009
(GDPD) 		4 VAL A 135
ILE A 157
ARG A  14
LEU A 139
 None
 0.88A 1iepB-5vugA:
undetectable		 1iepB-5vugA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whm ICLR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Brucella
abortus) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 VAL A 276
ILE A 117
ARG A 141
LEU A 272
 None
 0.96A 1iepB-5whmA:
undetectable		 1iepB-5whmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 4 LYS A 227
VAL A 247
VAL A 257
LEU A 326
 None
 0.92A 1iepB-5xzwA:
19.2		 1iepB-5xzwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ans UNCHARACTERIZED
PROTEIN

(Burkholderia
cenocepacia) 		PF06742
(DUF1214) 		4 VAL A 172
ILE A 189
ARG A 162
LEU A 113
 None
 1.02A 1iepB-6ansA:
undetectable		 1iepB-6ansA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 VAL A 787
MET A 816
ARG A 858
LEU A 866
 None
None
TPO  A 893 ( 3.0A)
CJM  A1102 (-4.4A)
 0.72A 1iepB-6b3eA:
23.0		 1iepB-6b3eA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 LYS A 213
VAL A 246
MET A 265
LEU A 318
 CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.9A)
CJT  A 502 (-4.7A)
 0.81A 1iepB-6f3dA:
23.5		 1iepB-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 VAL A 246
MET A 265
ARG A 310
LEU A 318
 None
CJT  A 502 (-4.9A)
TPO  A 345 ( 4.9A)
CJT  A 502 (-4.7A)
 0.87A 1iepB-6f3dA:
23.5		 1iepB-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 VAL A 209
VAL A 225
ILE A 239
LEU A 295
 None
None
None
EAQ  A 501 (-4.9A)
 0.89A 1iepB-6fyoA:
21.5		 1iepB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 VAL A 209
VAL A 225
ILE A 239
LEU A 295
 None
 0.87A 1iepB-6fyvA:
21.8		 1iepB-6fyvA:
undetectable