SIMILAR PATTERNS OF AMINO ACIDS FOR 1IEP_B_STIB202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
GLY A 340
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
 0.77A 1iepB-1opkA:
34.7		 1iepB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
GLY A 340
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-3.5A)
 0.78A 1iepB-1opkA:
34.7		 1iepB-1opkA:
58.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 164
VAL A 172
ALA A 185
GLU A 202
GLY A 250
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
None
 0.96A 1iepB-1q8yA:
14.5		 1iepB-1q8yA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
VAL A 603
ALA A 621
GLU A 640
THR A 670
GLY A 676
ASP A 810
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.9A)
 0.72A 1iepB-1t46A:
34.7		 1iepB-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 419
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
 0.86A 1iepB-1u59A:
30.4		 1iepB-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
 0.46A 1iepB-1u59A:
30.4		 1iepB-1u59A:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
 0.85A 1iepB-2bujA:
23.2		 1iepB-2bujA:
23.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
VAL X  25
ALA X  37
GLU X  54
MET X  58
THR X  82
GLY X  88
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 ( 4.1A)
 0.66A 1iepB-2dq7X:
32.4		 1iepB-2dq7X:
44.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 162
VAL A 170
ALA A 184
GLU A 201
GLY A 240
ALA A 319
 None
 0.78A 1iepB-2eu9A:
21.7		 1iepB-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 162
VAL A 170
ALA A 184
GLU A 201
ILE A 208
ALA A 319
 None
 0.53A 1iepB-2eu9A:
21.7		 1iepB-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
 0.82A 1iepB-2h8hA:
30.4		 1iepB-2h8hA:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
THR A 338
PHE A 340
GLY A 344
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.5A)
 0.94A 1iepB-2hckA:
29.9		 1iepB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 ( 4.5A)
 0.91A 1iepB-2hckA:
29.9		 1iepB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.90A 1iepB-2henA:
26.3		 1iepB-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.98A 1iepB-2hk5A:
27.6		 1iepB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.67A 1iepB-2hk5A:
27.6		 1iepB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.02A 1iepB-2hk5A:
27.6		 1iepB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 269
GLU A 286
MET A 290
ILE A 293
THR A 315
PHE A 317
GLY A 321
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.85A 1iepB-2hz0A:
34.9		 1iepB-2hz0A:
97.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
VAL A 256
ALA A 269
GLU A 286
MET A 290
ILE A 293
THR A 315
PHE A 317
GLY A 321
ALA A 380
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-3.1A)
 0.73A 1iepB-2hz0A:
34.9		 1iepB-2hz0A:
97.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
GLY A 322
ALA A 381
ASP A 382
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.71A 1iepB-2og8A:
27.0		 1iepB-2og8A:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 588
VAL A 596
ALA A 614
GLU A 633
MET A 637
THR A 663
GLY A 669
ASP A 796
 None
 0.97A 1iepB-2ogvA:
32.7		 1iepB-2ogvA:
38.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
ALA A 643
 None
 0.69A 1iepB-2psqA:
32.0		 1iepB-2psqA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
 1.15A 1iepB-2qluA:
24.4		 1iepB-2qluA:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.08A 1iepB-2qobA:
26.3		 1iepB-2qobA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
ASP A 818
 None
 1.06A 1iepB-2r2pA:
31.5		 1iepB-2r2pA:
37.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
GLU A  64
ILE A  71
GLY A  99
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
None
 0.83A 1iepB-2w4kA:
16.3		 1iepB-2w4kA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 112
VAL A 120
ALA A 133
GLU A 151
MET A 155
GLY A 186
 16X  A1374 (-4.1A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
None
None
16X  A1374 (-4.0A)
 0.80A 1iepB-2x4fA:
22.1		 1iepB-2x4fA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
VAL A 261
GLU A 290
MET A 294
THR A 319
PHE A 321
ASP A 385
 None
 1.27A 1iepB-2zv7A:
26.3		 1iepB-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
VAL A 261
MET A 294
THR A 319
PHE A 321
ALA A 384
ASP A 385
 None
 1.26A 1iepB-2zv7A:
26.3		 1iepB-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
GLU A 290
MET A 294
THR A 319
PHE A 321
ASP A 385
 None
 1.14A 1iepB-2zv7A:
26.3		 1iepB-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
MET A 294
THR A 319
PHE A 321
ALA A 384
ASP A 385
 None
 1.12A 1iepB-2zv7A:
26.3		 1iepB-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
 0.79A 1iepB-3b2tA:
25.3		 1iepB-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
 0.67A 1iepB-3b2tA:
25.3		 1iepB-3b2tA:
39.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
GLU A  64
ILE A  71
GLY A  99
 4RB  A 401 ( 3.9A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
GOL  A 503 (-2.8A)
None
None
 0.72A 1iepB-3bqrA:
20.6		 1iepB-3bqrA:
26.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1092
ALA A1108
GLU A1127
GLY A1163
ALA A1221
ASP A1222
 CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.92A 1iepB-3c1xA:
26.1		 1iepB-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1092
ALA A1108
GLU A1127
MET A1131
ALA A1221
ASP A1222
 CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.94A 1iepB-3c1xA:
26.1		 1iepB-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.67A 1iepB-3c4fA:
31.5		 1iepB-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 647
ALA A 663
GLU A 682
MET A 686
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.8A)
 0.79A 1iepB-3dkoA:
30.8		 1iepB-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
VAL A 841
ALA A 859
GLU A 878
ILE A 885
GLY A 915
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
 0.92A 1iepB-3hngA:
33.2		 1iepB-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
 None
None
None
None
None
GOL  A 403 (-3.4A)
 0.68A 1iepB-3kulA:
31.8		 1iepB-3kulA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 216
ALA A 227
ILE A 245
THR A 277
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 ( 3.8A)
None
 0.98A 1iepB-3my0A:
24.9		 1iepB-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
VAL A  96
ALA A 109
GLU A 130
MET A 134
GLY A 165
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
 0.53A 1iepB-3nuuA:
23.0		 1iepB-3nuuA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.73A 1iepB-3q4tA:
24.0		 1iepB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
 0.77A 1iepB-3q5iA:
20.0		 1iepB-3q5iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER

(Homo sapiens) 		PF00069
(Pkinase)
PF08332
(CaMKII_AD) 		6 LEU A  19
VAL A  27
ALA A  40
GLU A  60
GLY A  94
ALA A 155
 DB8  A 445 (-3.5A)
DB8  A 445 (-4.5A)
DB8  A 445 ( 4.2A)
DB8  A 445 ( 4.8A)
None
None
 1.03A 1iepB-3soaA:
19.5		 1iepB-3soaA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
ALA A 640
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
07J  A   1 (-3.7A)
07J  A   1 (-3.2A)
 0.68A 1iepB-3tt0A:
30.7		 1iepB-3tt0A:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
 0.73A 1iepB-3vidA:
30.4		 1iepB-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
 0.75A 1iepB-3wzdA:
31.4		 1iepB-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.84A 1iepB-3zfxA:
31.6		 1iepB-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
ASP A1046
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
None
 0.94A 1iepB-4agdA:
32.7		 1iepB-4agdA:
35.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
VAL A  50
ALA A  63
GLU A  81
PHE A 112
GLY A 116
ALA A 174
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 ( 4.3A)
 0.76A 1iepB-4bc6A:
21.7		 1iepB-4bc6A:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
VAL A  50
ALA A  63
ILE A  84
PHE A 112
GLY A 116
ALA A 174
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
None
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 ( 4.3A)
 0.97A 1iepB-4bc6A:
21.7		 1iepB-4bc6A:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
VAL A  30
ALA A  43
GLU A  64
GLY A  99
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
None
STU  A1550 (-3.4A)
STU  A1550 ( 3.8A)
 0.98A 1iepB-4cfhA:
22.7		 1iepB-4cfhA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
VAL A 624
ALA A 653
GLU A 672
MET A 676
THR A 701
GLY A 707
ALA A 783
ASP A 784
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.79A 1iepB-4ckrA:
32.7		 1iepB-4ckrA:
37.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
ALA A 684
GLU A 705
GLY A 743
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 ( 4.5A)
 0.72A 1iepB-4crsA:
16.7		 1iepB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.59A 1iepB-4eutA:
11.6		 1iepB-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.55A 1iepB-4euuA:
21.3		 1iepB-4euuA:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		6 ALA A1053
GLU A1078
MET A1082
PHE A1107
GLY A1111
ALA A1176
 None
 1.10A 1iepB-4f0gA:
26.3		 1iepB-4f0gA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		6 VAL A1040
ALA A1053
GLU A1078
PHE A1107
GLY A1111
ALA A1176
 None
 0.82A 1iepB-4f0gA:
26.3		 1iepB-4f0gA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ALA A 662
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
 0.66A 1iepB-4feqA:
22.8		 1iepB-4feqA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
ALA A 506
GLU A 525
MET A 529
ILE A 532
GLY A 561
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
None
 0.85A 1iepB-4k33A:
26.2		 1iepB-4k33A:
37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
ALA A 506
GLU A 525
MET A 529
ILE A 532
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
None
 0.66A 1iepB-4k33A:
26.2		 1iepB-4k33A:
37.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  41
ALA A  54
GLU A  70
MET A  74
GLY A 105
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
None
GOL  A 404 (-3.6A)
GOL  A 403 ( 3.0A)
 1.09A 1iepB-4lg4A:
17.7		 1iepB-4lg4A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  78
VAL A  86
ALA A  99
GLU A 117
MET A 121
GLY A 151
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-3.4A)
 0.77A 1iepB-4mvfA:
19.2		 1iepB-4mvfA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
GLU B  70
GLY B 104
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 3.4A)
 1.13A 1iepB-4o27B:
18.3		 1iepB-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
GLU B  70
GLY B 105
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 3.4A)
 0.98A 1iepB-4o27B:
18.3		 1iepB-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  46
VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
 0.76A 1iepB-4o38A:
19.1		 1iepB-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 386
VAL A 394
ALA A 407
GLU A 428
GLY A 464
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 ( 4.6A)
 0.80A 1iepB-4q9zA:
20.4		 1iepB-4q9zA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 345
VAL A 353
ALA A 366
GLU A 387
GLY A 423
ALA A 480
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
None
3KZ  A 701 ( 4.8A)
 0.95A 1iepB-4ra4A:
20.8		 1iepB-4ra4A:
28.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
None
 0.74A 1iepB-4rt7A:
29.0		 1iepB-4rt7A:
31.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  40
VAL A  48
ALA A  61
PHE A 110
GLY A 114
ALA A 172
ASP A 173
 6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 ( 4.1A)
None
 1.16A 1iepB-4usfA:
18.9		 1iepB-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
ZN  A 403 ( 2.6A)
 1.02A 1iepB-4wsqA:
22.6		 1iepB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
 0.77A 1iepB-4wsqA:
22.6		 1iepB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
ALA A  72
MET A  94
PHE A 128
GLY A 131
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
None
 0.71A 1iepB-4wsqA:
22.6		 1iepB-4wsqA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-3.0A)
 0.70A 1iepB-4xcuA:
31.3		 1iepB-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
VAL B 275
MET B 309
ILE B 312
THR B 334
PHE B 336
GLY B 340
ALA B 399
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.7A)
None
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.5A)
 0.95A 1iepB-4xeyB:
29.0		 1iepB-4xeyB:
71.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 VAL B 275
ALA B 288
MET B 309
ILE B 312
THR B 334
PHE B 336
GLY B 340
ALA B 399
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
None
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.5A)
 0.85A 1iepB-4xeyB:
29.0		 1iepB-4xeyB:
71.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
GLU A 509
THR A 539
GLY A 545
ALA A 605
 None
4CV  A 801 (-3.5A)
None
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
4CV  A 801 ( 3.9A)
 0.70A 1iepB-4yffA:
24.7		 1iepB-4yffA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
ALA A 214
GLU A 235
GLY A 270
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
AN2  A 601 (-3.0A)
 1.05A 1iepB-4yhjA:
19.8		 1iepB-4yhjA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  34
VAL A  42
ALA A  55
GLU A  76
THR A 105
GLY A 110
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
 0.77A 1iepB-4ysjA:
22.5		 1iepB-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  34
VAL A  42
ALA A  55
GLU A  76
THR A 105
GLY A 111
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
 0.71A 1iepB-4ysjA:
22.5		 1iepB-4ysjA:
23.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.72A 1iepB-5a46A:
30.5		 1iepB-5a46A:
35.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 258
ALA A 275
GLU A 290
THR A 325
PHE A 327
GLY A 331
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
 0.79A 1iepB-5e8yA:
18.8		 1iepB-5e8yA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 LEU A  99
VAL A 107
ALA A 120
PHE A 172
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
None
None
 0.59A 1iepB-5eykA:
17.5		 1iepB-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 LEU A  99
VAL A 107
ALA A 120
PHE A 172
GLY A 176
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
None
 0.68A 1iepB-5eykA:
17.5		 1iepB-5eykA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.8A)
 0.78A 1iepB-5grnA:
29.6		 1iepB-5grnA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
VAL A  28
ALA A  41
GLU A  61
GLY A  95
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
 0.98A 1iepB-5hu3A:
13.5		 1iepB-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
VAL A  28
ALA A  41
GLU A  61
GLY A  96
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
 0.77A 1iepB-5hu3A:
13.5		 1iepB-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.2A)
 0.78A 1iepB-5j5tA:
21.3		 1iepB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  43
MET A  65
PHE A  92
GLY A  95
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
TPO  A 145 ( 4.7A)
6G2  A 901 ( 4.2A)
 1.01A 1iepB-5j5tA:
21.3		 1iepB-5j5tA:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 647
ALA A 663
MET A 686
THR A 711
PHE A 713
ASP A 776
 None
6P6  A1001 (-3.3A)
6P6  A1001 ( 4.2A)
6P6  A1001 (-3.5A)
6P6  A1001 ( 4.5A)
None
 0.61A 1iepB-5l6oA:
33.0		 1iepB-5l6oA:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 593
ALA A 617
MET A 641
PHE A 673
ALA A 740
ASP A 741
 7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
 1.05A 1iepB-5td2A:
28.9		 1iepB-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 593
VAL A 601
ALA A 617
MET A 641
PHE A 673
GLY A 677
ALA A 740
 7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 ( 3.7A)
 0.87A 1iepB-5td2A:
28.9		 1iepB-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 542
VAL A 550
ALA A 565
PHE A 622
GLY A 626
ALA A 689
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
7YS  A9001 (-4.3A)
7YS  A9001 (-3.4A)
7YS  A9001 (-3.4A)
 0.75A 1iepB-5u6bA:
29.7		 1iepB-5u6bA:
43.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 116
VAL A 124
ALA A 137
GLU A 157
THR A 187
GLY A 191
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
 0.84A 1iepB-5vcxA:
18.1		 1iepB-5vcxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 LEU A  24
VAL A  32
ALA A  45
THR A  95
GLY A 101
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 ( 4.0A)
 0.74A 1iepB-5w5jA:
19.2		 1iepB-5w5jA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 LEU A 366
VAL A 374
ALA A 388
GLU A 409
MET A 413
GLY A 444
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
None
None
 0.72A 1iepB-6c0tA:
17.1		 1iepB-6c0tA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 VAL A  74
ALA A  87
GLU A 107
MET A 111
GLY A 142
ALA A 199
 None
 0.91A 1iepB-6c9dA:
21.1		 1iepB-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 6 LEU A 275
VAL A 283
ALA A 296
PHE A 345
GLY A 349
ASP A 411
 FE7  A 601 (-3.8A)
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.3A)
FE7  A 601 (-4.5A)
FE7  A 601 ( 3.7A)
MG  A 602 ( 2.6A)
 0.89A 1iepB-6cthA:
22.2		 1iepB-6cthA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 7 LEU U  20
VAL U  28
ALA U  42
PHE U  93
GLY U  97
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.88A 1iepB-6fdyU:
21.8		 1iepB-6fdyU:
undetectable