SIMILAR PATTERNS OF AMINO ACIDS FOR 1ICT_D_T44D129

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1s ORNITHINE
CARBAMOYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 139
ALA A 303
LEU A  24
THR A  26
 None
 1.05A 1ictB-1a1sA:
undetectable		 1ictB-1a1sA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbj IGG4-KAPPA B72.3 FAB
(HEAVY CHAIN)
IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)

(Homo sapiens;
Mus musculus) 		no annotation 4 LEU L 135
ALA H 138
SER H 133
THR H 136
 None
 0.98A 1ictB-1bbjL:
3.9		 1ictB-1bbjL:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6b GLUTATHIONE
S-TRANSFERASE

(Arabidopsis
thaliana) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		4 LEU A 147
ALA A 159
LEU A 150
THR A 160
 None
None
None
BME  A 389 ( 4.9A)
 1.04A 1ictB-1e6bA:
undetectable		 1ictB-1e6bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		4 LYS A  81
LEU A  78
ALA A  80
LEU A  75
 None
 1.07A 1ictB-1eb3A:
undetectable		 1ictB-1eb3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f80 HOLO-(ACYL CARRIER
PROTEIN) SYNTHASE

(Bacillus
subtilis) 		PF01648
(ACPS) 		4 LEU A   7
ALA A 111
SER A 102
THR A 104
 None
None
None
NA  A1255 (-3.8A)
 0.72A 1ictB-1f80A:
undetectable		 1ictB-1f80A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 LEU A 506
ALA A 563
LEU A 565
THR A 576
 None
 0.70A 1ictB-1g0dA:
0.1		 1ictB-1g0dA:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
 None
 0.64A 1ictB-1gkeA:
21.8		 1ictB-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gut MOLYBDATE BINDING
PROTEIN II

(Clostridium
pasteurianum) 		PF03459
(TOBE) 		4 LYS A  18
LEU A  16
ALA A  23
SER A  37
 None
 0.86A 1ictB-1gutA:
undetectable		 1ictB-1gutA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		5 LEU A 120
ALA A 116
LEU A 169
SER A 167
THR A 113
 None
 1.23A 1ictB-1hjuA:
undetectable		 1ictB-1hjuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		4 LEU A 183
ALA A 179
LEU A 185
THR A 176
 None
 1.07A 1ictB-1i36A:
undetectable		 1ictB-1i36A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izm HYPOTHETICAL PROTEIN
HI0817

(Haemophilus
influenzae) 		PF03695
(UPF0149) 		4 LEU A  42
ALA A  54
LEU A  45
SER A  49
 None
 1.01A 1ictB-1izmA:
undetectable		 1ictB-1izmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		4 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.93A 1ictB-1j0aA:
undetectable		 1ictB-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 LYS A 361
LEU A 357
ALA A 360
THR A 352
 None
 1.07A 1ictB-1jmyA:
undetectable		 1ictB-1jmyA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 LEU A 585
ALA A 291
LEU A 293
THR A 305
 None
 0.84A 1ictB-1k25A:
undetectable		 1ictB-1k25A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miu BREAST CANCER TYPE 2
SUSCEPTIBILITY
PROTEIN

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		4 LEU A2906
ALA A2948
LEU A2946
SER A2933
 None
 1.04A 1ictB-1miuA:
undetectable		 1ictB-1miuA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.81A 1ictB-1sb3B:
undetectable		 1ictB-1sb3B:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		4 LEU A  17
ALA A 108
LEU A 110
THR A 119
 None
 0.45A 1ictB-1sn2A:
20.4		 1ictB-1sn2A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
LEU A 110
THR A 119
 None
 0.76A 1ictB-1sn2A:
20.4		 1ictB-1sn2A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		5 LEU A 352
ALA A 323
LEU A 349
SER A 326
THR A 374
 None
 1.45A 1ictB-1sqgA:
undetectable		 1ictB-1sqgA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4n RIBONUCLEASE III

(Saccharomyces
cerevisiae) 		PF00035
(dsrm) 		4 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.99A 1ictB-1t4nA:
undetectable		 1ictB-1t4nA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
 None
 0.78A 1ictB-1tfpA:
19.2		 1ictB-1tfpA:
73.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
 None
 0.77A 1ictB-1tfpA:
19.2		 1ictB-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LYS A   2
ALA A 170
SER A 315
THR A 317
 None
 0.81A 1ictB-1tvzA:
undetectable		 1ictB-1tvzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uun MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.63A 1ictB-1uunA:
undetectable		 1ictB-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		4 LEU A 171
ALA A 146
SER A 221
THR A 223
 None
None
None
NAI  A1001 (-4.5A)
 0.99A 1ictB-1wnbA:
undetectable		 1ictB-1wnbA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum) 		PF01095
(Pectinesterase) 		4 LYS A 107
ALA A 103
LEU A  71
THR A 102
 None
 1.07A 1ictB-1xg2A:
undetectable		 1ictB-1xg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yht DSPB

(Aggregatibacter
actinomycetemcomitans) 		PF00728
(Glyco_hydro_20) 		4 LEU A 277
ALA A 325
LEU A 327
THR A  19
 None
 0.86A 1ictB-1yhtA:
undetectable		 1ictB-1yhtA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.81A 1ictB-1yr2A:
undetectable		 1ictB-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9l PROPHENOLOXIDASE
ACTIVATING FACTOR

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		4 ALA A 191
LEU A 196
SER A 188
THR A 270
 None
 0.93A 1ictB-2b9lA:
undetectable		 1ictB-2b9lA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bk9 CG9734-PA

(Drosophila
melanogaster) 		PF00042
(Globin) 		4 LEU A 114
ALA A 128
LEU A 117
SER A 121
 None
 1.03A 1ictB-2bk9A:
undetectable		 1ictB-2bk9A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bod ENDOGLUCANASE E-2

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		4 LYS X 202
ALA X 201
SER X 160
THR X 186
 None
 1.07A 1ictB-2bodX:
undetectable		 1ictB-2bodX:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2i RV0130

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 LEU A  70
LEU A  73
SER A  21
THR A 109
 None
 1.04A 1ictB-2c2iA:
undetectable		 1ictB-2c2iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs3 PROTEIN C14ORF4

(Homo sapiens) 		PF00097
(zf-C3HC4) 		4 LYS A  51
LEU A  87
ALA A  55
THR A  56
 None
 1.07A 1ictB-2cs3A:
undetectable		 1ictB-2cs3A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ism PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF07995
(GSDH) 		4 LEU A  45
ALA A  65
LEU A  55
SER A  62
 None
 1.05A 1ictB-2ismA:
undetectable		 1ictB-2ismA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc3 APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 LEU A  78
ALA A 164
SER A  22
THR A  18
 None
 1.06A 1ictB-2kc3A:
undetectable		 1ictB-2kc3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 LEU A 291
ALA A 304
LEU A 294
SER A 297
 None
 1.07A 1ictB-2o3jA:
undetectable		 1ictB-2o3jA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjd RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE C

(Escherichia
coli) 		PF05175
(MTS)
PF08468
(MTS_N) 		4 LEU A  11
ALA A   7
LEU A  12
THR A   5
 None
 1.08A 1ictB-2pjdA:
undetectable		 1ictB-2pjdA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		4 LEU A 199
ALA A 175
LEU A 177
SER A 151
 None
None
None
NAD  A 400 (-3.8A)
 1.05A 1ictB-2pv7A:
undetectable		 1ictB-2pv7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvz PRPF METHYLACONITATE
ISOMERASE

(Shewanella
oneidensis) 		PF04303
(PrpF) 		4 LYS A  59
ALA A  67
SER A  69
THR A  71
 CA  A1002 (-3.3A)
None
CA  A1003 (-3.3A)
None
 1.04A 1ictB-2pvzA:
undetectable		 1ictB-2pvzA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 LEU  A  62 ( 0.5A)
ALA  A 164 ( 0.0A)
LEU  A 166 ( 0.5A)
THR  A 176 ( 0.8A)
 0.55A 1ictB-2v9uA:
3.2		 1ictB-2v9uA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		4 LEU B  97
ALA A   7
LEU A   4
SER A   2
 None
 1.02A 1ictB-2vjtB:
undetectable		 1ictB-2vjtB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		4 LEU A  49
ALA A  38
LEU A  51
THR A  34
 None
 0.80A 1ictB-2w6dA:
undetectable		 1ictB-2w6dA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 LEU A 278
ALA A 219
SER A 296
THR A 223
 None
 1.06A 1ictB-2y0eA:
undetectable		 1ictB-2y0eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A

(Homo sapiens) 		PF02373
(JmjC) 		4 LEU A 496
LEU A 499
SER A 502
THR A 454
 None
 1.07A 1ictB-2yu1A:
undetectable		 1ictB-2yu1A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 LEU B 585
ALA B 291
LEU B 293
THR B 305
 None
 0.88A 1ictB-2z2mB:
undetectable		 1ictB-2z2mB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zch MONOCLONAL ANTIBODY
8G8F5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS H 205
ALA H 198
SER H 149
THR H 151
 None
 0.76A 1ictB-2zchH:
undetectable		 1ictB-2zchH:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		4 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.58A 1ictB-3b8kA:
undetectable		 1ictB-3b8kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.95A 1ictB-3bdwB:
undetectable		 1ictB-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		4 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.78A 1ictB-3d1rA:
undetectable		 1ictB-3d1rA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanocaldococcus
jannaschii) 		PF03201
(HMD) 		4 LEU A 337
ALA A 318
LEU A 315
THR A 317
 None
 1.08A 1ictB-3dafA:
undetectable		 1ictB-3dafA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3duz MAJOR ENVELOPE
GLYCOPROTEIN

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF03273
(Baculo_gp64) 		4 LYS A  49
LEU A  47
ALA A 227
LEU A 229
 None
 0.81A 1ictB-3duzA:
undetectable		 1ictB-3duzA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8u TAPASIN

(Homo sapiens) 		PF07654
(C1-set) 		4 ALA B 163
LEU B 142
SER B 161
THR B 231
 None
None
NAG  B1233 ( 4.6A)
None
 0.96A 1ictB-3f8uB:
2.1		 1ictB-3f8uB:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
 0.66A 1ictB-3fc8A:
22.7		 1ictB-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcm HYDROLASE, NUDIX
FAMILY

(Clostridium
perfringens) 		PF00293
(NUDIX) 		4 LEU A 130
LEU A  44
SER A  76
THR A  36
 None
 1.02A 1ictB-3fcmA:
undetectable		 1ictB-3fcmA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		4 LEU A 173
LEU A 146
SER A 224
THR A 226
 None
 0.89A 1ictB-3i44A:
undetectable		 1ictB-3i44A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
 0.88A 1ictB-3iwkA:
undetectable		 1ictB-3iwkA:
13.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iwu 5-HYDROXYISOURATE
HYDROLASE

(Danio rerio) 		PF00576
(Transthyretin) 		4 LEU A  14
LEU A 107
SER A 114
THR A 116
 None
 0.92A 1ictB-3iwuA:
19.5		 1ictB-3iwuA:
32.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 A223 PENTON BASE

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 ALA Q 215
LEU Q 217
SER Q 165
THR Q 167
 None
 0.81A 1ictB-3j31Q:
undetectable		 1ictB-3j31Q:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA

(Homo sapiens) 		PF00293
(NUDIX) 		4 LEU A  23
ALA A  21
LEU A  80
THR A  93
 None
 1.00A 1ictB-3mcfA:
undetectable		 1ictB-3mcfA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 LYS A 223
ALA A 261
LEU A  12
THR A 290
 2FP  A 350 (-2.2A)
None
None
None
 1.00A 1ictB-3mmtA:
undetectable		 1ictB-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1

(Saccharomyces
cerevisiae) 		PF12539
(Csm1) 		4 LYS A 119
ALA A 135
SER A 162
THR A 160
 None
 0.74A 1ictB-3n4xA:
undetectable		 1ictB-3n4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 111
LEU A 113
LEU A 155
THR A 148
 SO4  A   5 (-2.8A)
None
None
SO4  A 369 (-3.7A)
 0.92A 1ictB-3nuuA:
undetectable		 1ictB-3nuuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU B 280
LEU B 264
SER B 317
THR B 319
 None
 0.78A 1ictB-3prxB:
3.6		 1ictB-3prxB:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfo PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		4 LEU A  37
ALA A  61
LEU A  36
THR A  60
 None
 1.08A 1ictB-3qfoA:
undetectable		 1ictB-3qfoA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4i CITRATE LYASE

(Paraburkholderia
xenovorans) 		PF03328
(HpcH_HpaI) 		4 LEU A 148
ALA A 155
LEU A 149
THR A 152
 None
 0.97A 1ictB-3r4iA:
undetectable		 1ictB-3r4iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 EPITOPE SCAFFOLD
2BODX43

(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		PF01341
(Glyco_hydro_6) 		4 LYS X 190
ALA X 189
SER X 148
THR X 174
 None
 1.07A 1ictB-3ru8X:
undetectable		 1ictB-3ru8X:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruy ORNITHINE
AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 LEU A 303
ALA A 256
LEU A 300
SER A 296
 None
LLP  A 255 ( 3.6A)
None
None
 1.07A 1ictB-3ruyA:
undetectable		 1ictB-3ruyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY

(Lactobacillus
plantarum) 		PF00582
(Usp) 		4 LEU A  36
ALA A  83
LEU A  86
THR A  81
 None
 0.99A 1ictB-3s3tA:
undetectable		 1ictB-3s3tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		4 LYS A 197
LEU A 193
ALA A 196
SER A 225
 None
 0.88A 1ictB-3s51A:
undetectable		 1ictB-3s51A:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.97A 1ictB-3sagA:
undetectable		 1ictB-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1

(Homo sapiens) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 LEU A 180
ALA A 176
LEU A 181
THR A 174
 None
 1.01A 1ictB-3swlA:
undetectable		 1ictB-3swlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 240
ALA A 243
LEU A 239
THR A 187
 None
 1.05A 1ictB-3t6sA:
undetectable		 1ictB-3t6sA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 LEU A 484
ALA A 498
SER A 695
THR A 500
 None
 0.96A 1ictB-3ttfA:
undetectable		 1ictB-3ttfA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		4 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.92A 1ictB-3ty7A:
undetectable		 1ictB-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uog ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 152
ALA A  93
SER A  66
THR A 112
 None
 0.93A 1ictB-3uogA:
undetectable		 1ictB-3uogA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 LYS A 323
ALA A 168
SER A  92
THR A  94
 None
 0.92A 1ictB-3ut3A:
undetectable		 1ictB-3ut3A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 LEU A 164
ALA A 190
LEU A 188
SER A 159
 None
 1.03A 1ictB-3wa1A:
undetectable		 1ictB-3wa1A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LEU B1171
ALA B1047
LEU B1049
SER B1249
 None
 0.94A 1ictB-3zefB:
undetectable		 1ictB-3zefB:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 ALA A 893
LEU A 891
SER A 867
THR A 852
 None
 0.92A 1ictB-4a7kA:
undetectable		 1ictB-4a7kA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4s BCL-2-LIKE PROTEIN
10

(Homo sapiens) 		PF00452
(Bcl-2) 		4 LEU A 130
LEU A  16
SER A  19
THR A  95
 None
 1.06A 1ictB-4b4sA:
undetectable		 1ictB-4b4sA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LYS A  46
LEU A  48
SER A  87
THR A 151
 None
 1.08A 1ictB-4bi9A:
undetectable		 1ictB-4bi9A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ctd OUTER MEMBRANE
PROTEIN G

(Escherichia
coli) 		PF09381
(Porin_OmpG) 		4 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.71A 1ictB-4ctdA:
undetectable		 1ictB-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		4 LYS A  61
LEU A  63
LEU A 372
THR A 225
 None
 0.98A 1ictB-4d9iA:
undetectable		 1ictB-4d9iA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 257
ALA A 243
LEU A 241
THR A 204
 None
 1.04A 1ictB-4dyjA:
undetectable		 1ictB-4dyjA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0d POLY [ADP-RIBOSE]
POLYMERASE 16

(Homo sapiens) 		PF00644
(PARP) 		4 LEU A 204
ALA A  20
LEU A  18
SER A  99
 None
 1.08A 1ictB-4f0dA:
undetectable		 1ictB-4f0dA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 LEU M 260
ALA M 297
LEU M 263
SER M 267
 None
 0.90A 1ictB-4heaM:
undetectable		 1ictB-4heaM:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
None
None
NAD  A 601 (-4.2A)
 0.90A 1ictB-4i8qA:
undetectable		 1ictB-4i8qA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdz SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C)
PF17210
(SdrD_B) 		4 LEU A 433
ALA A 530
LEU A 532
THR A 542
 None
 0.75A 1ictB-4jdzA:
8.0		 1ictB-4jdzA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1y SALIVARY NITROPHORIN

(Cimex
lectularius) 		no annotation 4 LEU A  86
ALA A  41
SER A  13
THR A  11
 None
 0.92A 1ictB-4l1yA:
undetectable		 1ictB-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 4 LEU A 273
ALA A 277
LEU A 292
THR A 280
 None
 1.08A 1ictB-4lc9A:
undetectable		 1ictB-4lc9A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdv ANNEXIN

(Schistosoma
mansoni) 		PF00191
(Annexin) 		4 LEU A 355
LEU A 358
SER A 320
THR A 318
 None
 1.07A 1ictB-4mdvA:
undetectable		 1ictB-4mdvA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.73A 1ictB-4mr0A:
undetectable		 1ictB-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LYS A 409
LEU A 411
LEU A 454
THR A 447
 None
None
None
SEP  A 695 ( 4.8A)
 0.90A 1ictB-4q9zA:
undetectable		 1ictB-4q9zA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A

(Mus musculus) 		no annotation 4 LEU B 496
LEU B 499
SER B 502
THR B 454
 None
 0.99A 1ictB-4qx8B:
undetectable		 1ictB-4qx8B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyb UNCHARACTERIZED
PROTEIN

(Burkholderia
cenocepacia) 		PF10765
(DUF2591) 		4 LEU A  98
ALA A 102
SER A  94
THR A 105
 None
 1.06A 1ictB-4qybA:
undetectable		 1ictB-4qybA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 341
ALA A 329
LEU A 367
SER A 365
 None
 1.04A 1ictB-4r6gA:
undetectable		 1ictB-4r6gA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN
HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 LEU L 135
ALA H 142
SER H 137
THR H 140
 None
 1.08A 1ictB-4rqqL:
undetectable		 1ictB-4rqqL:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 LEU A 373
LEU A 361
SER A 352
THR A 354
 None
 0.82A 1ictB-4tr6A:
undetectable		 1ictB-4tr6A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Burkholderia
pseudomallei) 		PF06429
(Flg_bbr_C) 		4 LEU A 278
ALA A 212
SER A  85
THR A  81
 None
 0.94A 1ictB-4ut1A:
undetectable		 1ictB-4ut1A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
fortuitum) 		PF00722
(Glyco_hydro_16) 		4 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 1.04A 1ictB-4w65A:
undetectable		 1ictB-4w65A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		4 LYS A 137
THR A 147
THR A  73
VAL A  71
 None
 0.78A 1ictD-1b2hA:
undetectable		 1ictD-1b2hA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.79A 1ictD-1d6vL:
undetectable		 1ictD-1d6vL:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g84 IMMUNOGLOBULIN E

(Homo sapiens) 		PF07654
(C1-set) 		4 LYS A  10
LEU A  12
THR A   8
LEU A  29
 None
 0.76A 1ictD-1g84A:
undetectable		 1ictD-1g84A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LEU A  17
THR A 106
LEU A 110
THR A 119
VAL A 121
 None
 0.46A 1ictD-1gkeA:
21.9		 1ictD-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		4 THR A 305
SER A 215
THR A 217
VAL A 219
 None
 0.65A 1ictD-1hqsA:
undetectable		 1ictD-1hqsA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg5 GTP CYCLOHYDROLASE I
FEEDBACK REGULATORY
PROTEIN

(Rattus
norvegicus) 		PF06399
(GFRP) 		4 THR A  75
SER A  68
THR A  70
VAL A  72
 None
 0.74A 1ictD-1jg5A:
undetectable		 1ictD-1jg5A:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		5 LEU A  17
THR A 106
LEU A 110
THR A 119
VAL A 121
 None
 0.62A 1ictD-1sn2A:
20.4		 1ictD-1sn2A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		6 LEU A  17
THR A 106
LEU A 110
SER A 117
THR A 119
VAL A 121
 None
 0.52A 1ictD-1tfpA:
19.5		 1ictD-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1va9 DOWN SYNDROME CELL
ADHESION MOLECULE
LIKE-PROTEIN 1B

(Homo sapiens) 		PF00041
(fn3) 		4 THR A  35
SER A  31
THR A  81
VAL A  79
 None
 0.87A 1ictD-1va9A:
undetectable		 1ictD-1va9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 LEU A  90
THR A  36
SER A   8
VAL A  63
 None
 0.72A 1ictD-1xhlA:
undetectable		 1ictD-1xhlA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 LEU A 281
THR A 272
LEU A 276
VAL A 220
 None
 0.42A 1ictD-1y8pA:
undetectable		 1ictD-1y8pA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydu AT5G01610

(Arabidopsis
thaliana) 		PF04398
(DUF538) 		4 LYS A 114
LEU A 112
LEU A 117
THR A 138
 None
 0.71A 1ictD-1yduA:
undetectable		 1ictD-1yduA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f17 THIAMIN
PYROPHOSPHOKINASE 1

(Mus musculus) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 LEU A 172
THR A 231
THR A 197
VAL A 195
 None
 0.80A 1ictD-2f17A:
undetectable		 1ictD-2f17A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd5 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 LEU A  73
LEU A  77
SER A  78
VAL A 179
 None
 0.84A 1ictD-2fd5A:
undetectable		 1ictD-2fd5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 LEU A 236
THR A 248
SER A 209
VAL A 205
 GOL  A 303 ( 4.9A)
None
None
None
 0.85A 1ictD-2h26A:
undetectable		 1ictD-2h26A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 LEU A 266
THR A 246
SER A 305
THR A 307
 None
 0.63A 1ictD-2iceA:
3.8		 1ictD-2iceA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		4 LEU A 201
THR A 191
LEU A 195
VAL A 125
 None
 0.59A 1ictD-2iq1A:
undetectable		 1ictD-2iq1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 606
THR A 857
LEU A 635
THR A 637
 None
MD1  A1987 ( 4.1A)
None
MD1  A1987 (-3.5A)
 0.85A 1ictD-2ivfA:
undetectable		 1ictD-2ivfA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8x PROBABLE RNA
POLYMERASE SIGMA-C
FACTOR

(Mycobacterium
tuberculosis) 		PF08281
(Sigma70_r4_2) 		4 LEU A 141
THR A 162
LEU A 147
SER A 148
 None
SO4  A 108 (-3.7A)
None
None
 0.60A 1ictD-2o8xA:
undetectable		 1ictD-2o8xA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107

(Mycobacterium
tuberculosis) 		PF10862
(FcoT) 		4 LEU A 141
LEU A  54
SER A  47
THR A  49
 None
 0.47A 1ictD-2pfcA:
undetectable		 1ictD-2pfcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		4 THR A 641
LEU A 645
SER A 624
VAL A 620
 None
 0.82A 1ictD-2qv3A:
undetectable		 1ictD-2qv3A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato bushy
stunt virus) 		PF00729
(Viral_coat) 		4 LEU A 132
THR A 243
LEU A 239
VAL A 176
 None
 0.83A 1ictD-2tbvA:
undetectable		 1ictD-2tbvA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 LYS A 400
THR A 352
THR A 434
VAL A 432
 None
 0.84A 1ictD-2xtlA:
5.9		 1ictD-2xtlA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 LYS A 137
THR A 147
THR A  73
VAL A  71
 None
 0.70A 1ictD-2z23A:
undetectable		 1ictD-2z23A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 THR A 235
SER A 177
THR A 179
VAL A 181
 None
 0.82A 1ictD-3blwA:
undetectable		 1ictD-3blwA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		4 THR A 303
SER A 226
THR A 228
VAL A 230
 None
 0.68A 1ictD-3dmsA:
undetectable		 1ictD-3dmsA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU B 288
THR B 261
THR B 208
VAL B 210
 None
 0.67A 1ictD-3exhB:
undetectable		 1ictD-3exhB:
16.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		5 LEU A  17
THR A 106
LEU A 110
THR A 119
VAL A 121
 IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
None
 0.49A 1ictD-3fc8A:
22.7		 1ictD-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge2 LIPOPROTEIN,
PUTATIVE

(Streptococcus
pneumoniae) 		PF12182
(DUF3642) 		4 THR A  96
LEU A 100
THR A  87
VAL A  89
 None
 0.47A 1ictD-3ge2A:
undetectable		 1ictD-3ge2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 LEU A 493
LEU A 549
SER A 462
THR A 464
 None
 0.76A 1ictD-3hjrA:
undetectable		 1ictD-3hjrA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		4 LEU A 173
LEU A 146
SER A 224
THR A 226
 None
 0.72A 1ictD-3i44A:
undetectable		 1ictD-3i44A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
 0.84A 1ictD-3iwkA:
undetectable		 1ictD-3iwkA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd4 PUTATIVE PROTEASE

(Parabacteroides
distasonis) 		PF12969
(DUF3857)
PF12970
(DUF3858) 		4 LYS A 394
THR A 449
THR A 492
VAL A 490
 None
 0.85A 1ictD-3kd4A:
undetectable		 1ictD-3kd4A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 THR A 108
LEU A  79
SER A  80
VAL A 111
 None
 0.74A 1ictD-3m49A:
undetectable		 1ictD-3m49A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 LYS A 160
THR A  86
SER A  77
THR A  79
 None
 0.66A 1ictD-3m8uA:
undetectable		 1ictD-3m8uA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nps S4 FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU C 135
THR C 172
SER C 162
THR C 164
 None
 0.71A 1ictD-3npsC:
undetectable		 1ictD-3npsC:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 LEU A 223
THR A 274
SER A 232
THR A 236
 None
 0.85A 1ictD-3o4rA:
undetectable		 1ictD-3o4rA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU B 280
LEU B 264
SER B 317
THR B 319
 None
 0.60A 1ictD-3prxB:
2.0		 1ictD-3prxB:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpi LIGHT CHAIN FROM
HIGHLY POTENT
ANTI-HIV
NEUTRALIZING
ANTIBODY

(Homo sapiens) 		no annotation 4 LEU L 124
THR L 161
SER L 151
THR L 153
 None
 0.79A 1ictD-3rpiL:
undetectable		 1ictD-3rpiL:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 ANTIBODY B12, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 136
THR L 173
SER L 163
THR L 165
 None
None
GOL  L 217 ( 3.7A)
None
 0.71A 1ictD-3ru8L:
3.9		 1ictD-3ru8L:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4y THIAMIN
PYROPHOSPHOKINASE 1

(Homo sapiens) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 LEU A 172
THR A 231
THR A 197
VAL A 195
 None
 0.84A 1ictD-3s4yA:
undetectable		 1ictD-3s4yA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 LYS A 163
THR A 173
THR A  99
VAL A  97
 None
 0.82A 1ictD-3tchA:
undetectable		 1ictD-3tchA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		4 LYS A 189
THR A 206
THR A 674
VAL A 672
 None
 0.65A 1ictD-3txaA:
undetectable		 1ictD-3txaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		4 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.75A 1ictD-3ty7A:
undetectable		 1ictD-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4b CH02 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.75A 1ictD-3u4bL:
3.8		 1ictD-3u4bL:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 125
THR A1605
SER A 207
THR A 209
 None
 0.81A 1ictD-4c3hA:
undetectable		 1ictD-4c3hA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6j LIGHT CHAIN OF
ANTIBODY BINDING
FRAGMENT OF
CANAKINUMAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.72A 1ictD-4g6jL:
undetectable		 1ictD-4g6jL:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV

(Borreliella
burgdorferi) 		PF00496
(SBP_bac_5) 		4 LYS A 156
THR A 166
THR A  93
VAL A  91
 None
 0.76A 1ictD-4gl8A:
undetectable		 1ictD-4gl8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 249
THR L 286
SER L 276
THR L 278
 None
None
GOL  L 401 (-3.3A)
None
 0.74A 1ictD-4hjjL:
undetectable		 1ictD-4hjjL:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 139
THR L 176
SER L 166
THR L 168
 None
 0.66A 1ictD-4ht1L:
undetectable		 1ictD-4ht1L:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3r LIGHT CHAIN OF
VRC-PG04 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.82A 1ictD-4i3rL:
2.6		 1ictD-4i3rL:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
None
None
NAD  A 601 (-4.2A)
 0.81A 1ictD-4i8qA:
undetectable		 1ictD-4i8qA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)

(Homo sapiens) 		no annotation 4 LEU H 157
THR H 194
SER H 184
THR H 186
 None
 0.82A 1ictD-4imlH:
undetectable		 1ictD-4imlH:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6r LIGHT CHAIN OF
ANTIBODY VRC23

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.72A 1ictD-4j6rL:
3.0		 1ictD-4j6rL:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfz FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.78A 1ictD-4jfzL:
4.0		 1ictD-4jfzL:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jm4 PGT 135 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.75A 1ictD-4jm4L:
undetectable		 1ictD-4jm4L:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpw LIGHT CHAIN OF
ANTIBODY 12A21

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.78A 1ictD-4jpwL:
3.4		 1ictD-4jpwL:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 134
THR B 171
SER B 161
THR B 163
 None
 0.81A 1ictD-4jznB:
undetectable		 1ictD-4jznB:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krp CETUXIMAB LIGHT
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU C 135
THR C 172
SER C 162
THR C 164
 None
 0.67A 1ictD-4krpC:
undetectable		 1ictD-4krpC:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1y SALIVARY NITROPHORIN

(Cimex
lectularius) 		no annotation 4 LEU A  86
SER A  13
THR A  11
VAL A   9
 None
 0.76A 1ictD-4l1yA:
undetectable		 1ictD-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsq LIGHT CHAIN OF
ANTIBODY VRC-CH31
WITH N70D MUTATION

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.79A 1ictD-4lsqL:
undetectable		 1ictD-4lsqL:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ma3 C2095 LIGHT CHAIN

(Homo sapiens;
Oryctolagus
cuniculus) 		no annotation 4 LEU L 141
THR L 178
SER L 168
THR L 170
 None
 0.72A 1ictD-4ma3L:
undetectable		 1ictD-4ma3L:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		4 LEU A 117
THR A 331
LEU A 120
VAL A 330
 None
 0.87A 1ictD-4mfiA:
undetectable		 1ictD-4mfiA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 213
LEU A 227
SER A 154
VAL A 150
 None
None
GOL  A 402 (-2.8A)
None
 0.84A 1ictD-4mioA:
undetectable		 1ictD-4mioA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 395
SER A 373
THR A 349
VAL A 325
 None
 0.86A 1ictD-4mnaA:
undetectable		 1ictD-4mnaA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3o PUTATIVE
D-GLYCERO-D-MANNO-HE
PTOSE 7-PHOSPHATE
KINASE

(Campylobacter
jejuni) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A 101
THR A   8
LEU A  45
VAL A 334
 None
 0.86A 1ictD-4n3oA:
undetectable		 1ictD-4n3oA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nec PUTATIVE
SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
lasaliensis) 		PF13649
(Methyltransf_25) 		4 LEU A 218
THR A 107
LEU A 142
SER A 111
 None
None
None
SAH  A 401 (-3.3A)
 0.78A 1ictD-4necA:
undetectable		 1ictD-4necA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 LEU A 352
THR A 364
SER A 325
VAL A 321
 None
 0.83A 1ictD-4onoA:
undetectable		 1ictD-4onoA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0e MAF-LIKE PROTEIN
YHDE

(Escherichia
coli) 		PF02545
(Maf) 		4 LEU A  67
THR A 105
LEU A 109
VAL A 120
 None
 0.60A 1ictD-4p0eA:
undetectable		 1ictD-4p0eA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phb UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF14262
(Cthe_2159) 		4 LYS A 189
THR A 164
THR A 130
VAL A 128
 None
 0.69A 1ictD-4phbA:
undetectable		 1ictD-4phbA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR

(Homo sapiens) 		PF00021
(UPAR_LY6) 		4 THR U  26
SER U  65
THR U  67
VAL U  69
 None
 0.58A 1ictD-4qtiU:
undetectable		 1ictD-4qtiU:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 325
THR A 304
LEU A 308
VAL A 281
 None
 0.73A 1ictD-4rjkA:
undetectable		 1ictD-4rjkA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rx4 8ANC134 LIGHT CHAIN

(Homo sapiens) 		no annotation 4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.67A 1ictD-4rx4L:
2.8		 1ictD-4rx4L:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wo4 ANTIGEN-PRESENTING
GLYCOPROTEIN CD1D

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 LEU A 236
THR A 248
SER A 209
VAL A 205
 None
 0.81A 1ictD-4wo4A:
undetectable		 1ictD-4wo4A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xny LIGHT CHAIN OF
ANTIBODY VRC08C

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.68A 1ictD-4xnyL:
undetectable		 1ictD-4xnyL:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi LIGHT CHAIN OF
ANTIBODY
Z258-VRC27.01

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.68A 1ictD-4ydiL:
undetectable		 1ictD-4ydiL:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydl LIGHT CHAIN OF
ANTIBODY
C38-VRC18.02

(Homo sapiens) 		no annotation 4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.67A 1ictD-4ydlL:
undetectable		 1ictD-4ydlL:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye4 LIGHT CHAIN OF HJ16

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 142
THR L 179
SER L 169
THR L 171
 None
 0.72A 1ictD-4ye4L:
undetectable		 1ictD-4ye4L:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ado FAB A.17

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 137
THR L 174
SER L 164
THR L 166
 None
 0.77A 1ictD-5adoL:
undetectable		 1ictD-5adoL:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5al7 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6
HOMOLOG

(Drosophila
melanogaster) 		PF16531
(SAS-6_N) 		4 LEU A  47
LEU A  62
THR A  74
VAL A  76
 None
 0.55A 1ictD-5al7A:
undetectable		 1ictD-5al7A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9j T-CELL SURFACE
GLYCOPROTEIN
CD1C,T-CELL SURFACE
GLYCOPROTEIN CD1B

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 LEU A 240
THR A 252
SER A 213
VAL A 209
 None
 0.82A 1ictD-5c9jA:
undetectable		 1ictD-5c9jA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cma ANTIBODY CH8H9 FAB
LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 135
THR A 172
SER A 162
THR A 164
 None
 0.75A 1ictD-5cmaA:
3.7		 1ictD-5cmaA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyb LIPOPROTEIN

(Streptococcus
pneumoniae) 		PF12182
(DUF3642) 		4 THR A  95
LEU A  99
THR A  86
VAL A  88
 None
 0.43A 1ictD-5cybA:
undetectable		 1ictD-5cybA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.68A 1ictD-5dd5L:
3.8		 1ictD-5dd5L:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5drz HIV ANTIBODY F240
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.82A 1ictD-5drzL:
undetectable		 1ictD-5drzL:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 135
THR B 172
SER B 162
THR B 164
 None
 0.75A 1ictD-5fgcB:
undetectable		 1ictD-5fgcB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5v FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF02465
(FliD_N)
PF07195
(FliD_C) 		4 LYS A  94
THR A 261
SER A  74
THR A  76
 None
 0.71A 1ictD-5h5vA:
undetectable		 1ictD-5h5vA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		4 LEU B 369
SER B 347
THR B 323
VAL B 299
 None
 0.83A 1ictD-5hz1B:
undetectable		 1ictD-5hz1B:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8k HHH1 FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 138
THR L 175
SER L 165
THR L 167
 None
 0.73A 1ictD-5i8kL:
undetectable		 1ictD-5i8kL:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8o HMM5 ANTIBODY LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 138
THR L 175
SER L 165
THR L 167
 None
 0.77A 1ictD-5i8oL:
undetectable		 1ictD-5i8oL:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmc SYNAPTIC VESICLE
GLYCOPROTEIN 2C

(Rattus
norvegicus) 		PF13599
(Pentapeptide_4) 		4 LYS B 533
THR B 511
THR B 493
VAL B 491
 None
 0.60A 1ictD-5jmcB:
undetectable		 1ictD-5jmcB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 LEU B 454
THR B 484
LEU B 437
VAL B 481
 None
 0.83A 1ictD-5kohB:
undetectable		 1ictD-5kohB:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 4 LEU B 147
THR B 124
LEU B 128
THR B 119
 None
 0.67A 1ictD-5ofbB:
undetectable		 1ictD-5ofbB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te6 LIGHT CHAIN OF N6

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.69A 1ictD-5te6L:
3.3		 1ictD-5te6L:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		4 THR A 386
LEU A 363
SER A 364
VAL A 368
 EDO  A 505 ( 3.9A)
None
None
None
 0.65A 1ictD-5u0lA:
undetectable		 1ictD-5u0lA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3k DH511.2 FAB LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.71A 1ictD-5u3kL:
undetectable		 1ictD-5u3kL:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3n DH511.12P FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.77A 1ictD-5u3nL:
undetectable		 1ictD-5u3nL:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3p DH511.4 FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.69A 1ictD-5u3pL:
undetectable		 1ictD-5u3pL:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bja ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 4 THR A  87
SER A  83
THR A  55
VAL A  57
 None
 0.72A 1ictD-6bjaA:
undetectable		 1ictD-6bjaA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 THR A1773
SER A1784
THR A1786
VAL A1788
 None
 0.44A 1ictD-6fb3A:
undetectable		 1ictD-6fb3A:
22.69