SIMILAR PATTERNS OF AMINO ACIDS FOR 1IBG_H_OBNH1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf5 PROTEIN
(BETA-MOMORCHARIN)

(Momordica
charantia) 		PF00161
(RIP) 		4 LEU A 112
PHE A  83
TYR A 140
VAL A  71
 None
 1.27A 1ibgH-1cf5A:
undetectable		 1ibgH-1cf5A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cii COLICIN IA

(Escherichia
coli) 		PF01024
(Colicin)
PF11504
(Colicin_Ia) 		4 LEU A 567
TRP A 551
PHE A 555
VAL A 559
 None
 1.33A 1ibgH-1ciiA:
0.0		 1ibgH-1ciiA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		4 LEU B 107
TRP B 138
PHE B  51
VAL B  40
 None
 1.30A 1ibgH-1gydB:
0.0		 1ibgH-1gydB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		4 LEU A 149
PHE A 147
TYR A 457
VAL A  73
 None
 1.30A 1ibgH-1lfwA:
undetectable		 1ibgH-1lfwA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 LEU A 272
PHE A 281
TYR A 194
VAL A 225
 None
 1.31A 1ibgH-1qniA:
0.0		 1ibgH-1qniA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
SMALL SUBUNIT

(Rhodococcus
jostii) 		PF00866
(Ring_hydroxyl_B) 		4 HIS B 111
LEU B  37
TRP B  45
VAL B 135
 None
 1.29A 1ibgH-1uliB:
undetectable		 1ibgH-1uliB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 HIS A 177
LEU A 152
TYR A 274
VAL A 265
 None
 1.31A 1ibgH-1w25A:
1.6		 1ibgH-1w25A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A 383
PHE A 342
TYR A 267
VAL A 339
 None
None
None
IPA  A1393 (-3.6A)
 1.08A 1ibgH-1wb0A:
undetectable		 1ibgH-1wb0A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wru 43 KDA TAIL PROTEIN

(Escherichia
virus Mu) 		PF05954
(Phage_GPD) 		4 LEU A 110
PHE A 174
TYR A 150
VAL A 125
 None
 1.31A 1ibgH-1wruA:
undetectable		 1ibgH-1wruA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		4 LEU A  30
PHE A 371
TYR A 132
VAL A 104
 None
 1.30A 1ibgH-1xkdA:
undetectable		 1ibgH-1xkdA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 LEU A 127
TRP A 132
PHE A 108
VAL A 194
 None
 1.12A 1ibgH-1xvxA:
undetectable		 1ibgH-1xvxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 LEU A 124
TRP A 129
PHE A 105
VAL A 191
 None
 1.18A 1ibgH-1xvyA:
undetectable		 1ibgH-1xvyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv7 GLYCOLIPID TRANSFER
PROTEIN

(Bos taurus) 		PF08718
(GLTP) 		4 HIS A 140
LEU A 136
PHE A 148
VAL A 144
 GM3  A1212 (-3.6A)
GM3  A1212 (-4.3A)
GM3  A1212 (-4.6A)
None
 1.02A 1ibgH-2bv7A:
undetectable		 1ibgH-2bv7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 LEU A 131
PHE A 117
TYR A 110
VAL A 153
 None
 1.22A 1ibgH-2e8yA:
3.2		 1ibgH-2e8yA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 LEU A 223
PHE A 346
TYR A 402
VAL A 178
 None
 1.25A 1ibgH-2gmhA:
undetectable		 1ibgH-2gmhA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwj HYPOTHETICAL PROTEIN
ATU1540

(Agrobacterium
fabrum) 		PF08857
(ParBc_2) 		4 HIS A 196
LEU A 197
TRP A 161
PHE A 164
 None
 1.20A 1ibgH-2hwjA:
undetectable		 1ibgH-2hwjA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyo UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Deinococcus
geothermalis) 		PF02627
(CMD) 		4 LEU A  30
TRP A  59
PHE A  45
VAL A  41
 None
 0.90A 1ibgH-2oyoA:
undetectable		 1ibgH-2oyoA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p87 PRE-MRNA-SPLICING
FACTOR PRP8

(Caenorhabditis
elegans) 		PF01398
(JAB)
PF08084
(PROCT) 		4 LEU A2156
TRP A2199
PHE A2120
VAL A2141
 None
 1.12A 1ibgH-2p87A:
undetectable		 1ibgH-2p87A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		4 LEU A   6
PHE A  21
TYR A 199
VAL A  18
 None
 1.15A 1ibgH-2pn1A:
undetectable		 1ibgH-2pn1A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		4 HIS A 410
LEU A 359
PHE A  93
VAL A 467
 None
 1.18A 1ibgH-2pyxA:
undetectable		 1ibgH-2pyxA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360

(Arabidopsis
thaliana) 		PF02668
(TauD) 		4 HIS A 121
LEU A 312
TYR A  17
VAL A 246
 None
 1.31A 1ibgH-2q4aA:
undetectable		 1ibgH-2q4aA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qiw PEP PHOSPHONOMUTASE

(Corynebacterium
glutamicum) 		PF13714
(PEP_mutase) 		4 HIS A  15
LEU A  21
PHE A  11
VAL A 147
 None
GOL  A 258 (-4.6A)
None
None
 1.17A 1ibgH-2qiwA:
undetectable		 1ibgH-2qiwA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU

(Homo sapiens) 		PF00041
(fn3)
PF00047
(ig)
PF00629
(MAM) 		4 LEU A 125
TRP A 110
PHE A  79
VAL A 155
 None
 1.29A 1ibgH-2v5yA:
6.2		 1ibgH-2v5yA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		4 HIS C  21
TRP C  14
PHE C  22
VAL C  25
 MQ7  C1252 (-4.1A)
MQ7  C1252 ( 4.5A)
None
None
 1.06A 1ibgH-2vpwC:
undetectable		 1ibgH-2vpwC:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy2 PROTEIN LEAFY

(Arabidopsis
thaliana) 		PF17538
(C_LFY_FLO) 		4 LEU A 382
PHE A 367
TYR A 264
VAL A 366
 None
 1.26A 1ibgH-2vy2A:
undetectable		 1ibgH-2vy2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF13599
(Pentapeptide_4) 		4 LEU A 182
TRP A 164
PHE A 174
VAL A 194
 None
None
None
LP6  A 193 ( 2.7A)
 1.30A 1ibgH-2w7zA:
undetectable		 1ibgH-2w7zA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjz IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH

(Thermotoga
maritima) 		PF00117
(GATase) 		4 LEU B 189
PHE B 175
TYR B  79
VAL B  83
 None
 1.20A 1ibgH-2wjzB:
undetectable		 1ibgH-2wjzB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		4 LEU A 130
PHE A 315
TYR A 166
VAL A 328
 None
 0.96A 1ibgH-2x1cA:
undetectable		 1ibgH-2x1cA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 HIS A  99
LEU A 117
TYR A  52
VAL A  82
 None
 1.34A 1ibgH-2xsgA:
2.4		 1ibgH-2xsgA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A 277
TRP A 231
PHE A 239
VAL A 243
 None
 1.21A 1ibgH-2y3sA:
undetectable		 1ibgH-2y3sA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		4 LEU A 222
PHE A 239
TYR A 251
VAL A 190
 None
 1.23A 1ibgH-2za1A:
undetectable		 1ibgH-2za1A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a45 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Acanthamoeba
polyphaga
mimivirus) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		4 LEU A  14
TRP A  88
PHE A  64
VAL A  52
 None
 1.32A 1ibgH-3a45A:
undetectable		 1ibgH-3a45A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		5 LEU A 328
TRP A 344
PHE A 341
TYR A 359
VAL A 396
 None
 1.49A 1ibgH-3b8zA:
undetectable		 1ibgH-3b8zA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		4 HIS H 260
LEU H 266
TRP H 281
PHE H 259
 None
 1.29A 1ibgH-3c75H:
undetectable		 1ibgH-3c75H:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 LEU A 149
TRP A 177
TYR A 190
VAL A  61
 None
 1.31A 1ibgH-3ciaA:
undetectable		 1ibgH-3ciaA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8j COPROPORPHYRINOGEN
III OXIDASE

(Leishmania
naiffi) 		PF01218
(Coprogen_oxidas) 		4 LEU A  13
PHE A  63
TYR A  67
VAL A  92
 None
 1.16A 1ibgH-3e8jA:
undetectable		 1ibgH-3e8jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeh PUTATIVE LIGHT AND
REDOX SENSING
HISTIDINE KINASE

(Haloarcula
marismortui) 		PF08447
(PAS_3) 		4 LEU A  31
PHE A  27
TYR A  41
VAL A 117
 None
 1.08A 1ibgH-3eehA:
undetectable		 1ibgH-3eehA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehk PRUNIN

(Prunus dulcis) 		PF00190
(Cupin_1) 		4 HIS A 170
TRP A 191
PHE A 313
VAL A 314
 None
 1.20A 1ibgH-3ehkA:
undetectable		 1ibgH-3ehkA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas
putida) 		PF00866
(Ring_hydroxyl_B) 		4 HIS B 111
LEU B  37
TRP B  45
VAL B 135
 None
 1.32A 1ibgH-3eqqB:
undetectable		 1ibgH-3eqqB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijd UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF02219
(MTHFR) 		4 LEU A 231
TRP A 230
PHE A 227
VAL A 282
 C2F  A 314 (-3.9A)
None
C2F  A 315 (-3.7A)
C2F  A 315 (-4.7A)
 1.30A 1ibgH-3ijdA:
undetectable		 1ibgH-3ijdA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF05076
(SUFU) 		4 LEU A 128
PHE A  67
TYR A 169
VAL A  54
 None
None
GOL  A 187 ( 4.9A)
None
 1.21A 1ibgH-3k5jA:
undetectable		 1ibgH-3k5jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina) 		PF08718
(GLTP) 		4 HIS A 147
LEU A 143
PHE A 155
VAL A 151
 None
MLY  A 144 ( 4.3A)
None
MLY  A 152 ( 3.2A)
 1.00A 1ibgH-3kv0A:
undetectable		 1ibgH-3kv0A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo sapiens) 		PF02373
(JmjC) 		4 LEU A 160
PHE A 294
TYR A 313
VAL A 297
 None
None
SO4  A 352 ( 3.8A)
None
 1.23A 1ibgH-3ld8A:
undetectable		 1ibgH-3ld8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A 113
PHE A 206
TYR A 174
VAL A 204
 None
 1.24A 1ibgH-3lijA:
undetectable		 1ibgH-3lijA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		4 LEU A 358
PHE A 415
TYR A 552
VAL A 409
 None
 1.17A 1ibgH-3rdeA:
undetectable		 1ibgH-3rdeA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		4 LEU A 225
PHE A 338
TYR A 205
VAL A 337
 None
 1.32A 1ibgH-3sqiA:
undetectable		 1ibgH-3sqiA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 1
SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF)
PF12026
(DUF3513) 		4 HIS B 790
LEU A 623
PHE B 794
VAL B 793
 None
 1.17A 1ibgH-3t6gB:
undetectable		 1ibgH-3t6gB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		4 TRP A 176
PHE A 123
TYR A 220
VAL A 126
 None
 1.23A 1ibgH-3vsmA:
undetectable		 1ibgH-3vsmA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		4 LEU A 105
TRP A 192
PHE A  75
VAL A  94
 None
 1.24A 1ibgH-3wviA:
undetectable		 1ibgH-3wviA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		4 LEU A 257
PHE A 224
TYR A 204
VAL A 266
 None
 1.22A 1ibgH-4avcA:
undetectable		 1ibgH-4avcA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4big UNCHARACTERIZED
LIPOPROTEIN
SAOUHSC_00053

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 LEU A 212
PHE A 232
TYR A  44
VAL A 195
 None
 1.27A 1ibgH-4bigA:
undetectable		 1ibgH-4bigA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bih UNCHARACTERIZED
LIPOPROTEIN
SAOUHSC_00053

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 LEU A 211
PHE A 231
TYR A  43
VAL A 194
 None
 1.33A 1ibgH-4bihA:
undetectable		 1ibgH-4bihA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		4 LEU A 176
TRP A 172
PHE A 150
VAL A  36
 None
 1.29A 1ibgH-4dpyA:
undetectable		 1ibgH-4dpyA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		4 LEU A 257
PHE A  99
TYR A  56
VAL A 102
 None
 1.30A 1ibgH-4f1rA:
undetectable		 1ibgH-4f1rA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl0 GALECTIN

(Toxascaris
leonina) 		PF00337
(Gal-bind_lectin) 		4 LEU A  25
TRP A 141
PHE A 128
VAL A 130
 None
 1.02A 1ibgH-4hl0A:
undetectable		 1ibgH-4hl0A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7i RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 LEU A 280
PHE A 316
TYR A 341
VAL A 348
 None
 0.94A 1ibgH-4i7iA:
undetectable		 1ibgH-4i7iA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i96 RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR) 		4 LEU A 280
PHE A 316
TYR A 341
VAL A 348
 None
 0.93A 1ibgH-4i96A:
undetectable		 1ibgH-4i96A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg3 CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		4 LEU A 260
PHE A 102
TYR A  59
VAL A 105
 None
 1.30A 1ibgH-4jg3A:
undetectable		 1ibgH-4jg3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08718
(GLTP) 		4 HIS A 150
LEU A 146
TRP A 117
VAL A 154
 1T9  A 301 (-4.5A)
1T9  A 301 (-4.6A)
1T9  A 301 (-4.0A)
1T9  A 301 ( 4.1A)
 1.13A 1ibgH-4kf6A:
undetectable		 1ibgH-4kf6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH

(Lechevalieria
aerocolonigenes) 		PF04820
(Trp_halogenase) 		4 HIS A 406
LEU A 356
PHE A  84
VAL A 474
 None
 1.14A 1ibgH-4lu6A:
undetectable		 1ibgH-4lu6A:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m1g MURINE IGG2A A27D7
HEAVY CHAIN FAB
DOMAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 HIS H  98
LEU H 105
TRP H 108
VAL H  50
 None
 1.20A 1ibgH-4m1gH:
27.6		 1ibgH-4m1gH:
82.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Anaerococcus
prevotii) 		PF03480
(DctP) 		4 LEU A 254
TRP A 250
PHE A 262
VAL A 261
 None
 1.30A 1ibgH-4n91A:
undetectable		 1ibgH-4n91A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn0 COMPLEMENT C1Q TUMOR
NECROSIS
FACTOR-RELATED
PROTEIN 5

(Homo sapiens) 		PF00386
(C1q) 		4 LEU A 168
PHE A 153
TYR A 136
VAL A 197
 None
 1.23A 1ibgH-4nn0A:
undetectable		 1ibgH-4nn0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo0 MAF-LIKE PROTEIN
BCAL2394

(Burkholderia
cenocepacia) 		PF02545
(Maf) 		4 HIS A 125
LEU A 120
PHE A 152
VAL A 150
 None
 1.31A 1ibgH-4oo0A:
undetectable		 1ibgH-4oo0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0e MAF-LIKE PROTEIN
YHDE

(Escherichia
coli) 		PF02545
(Maf) 		4 HIS A 101
LEU A  96
PHE A 126
VAL A 124
 None
 1.33A 1ibgH-4p0eA:
undetectable		 1ibgH-4p0eA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbc D-AMINO ACID
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01063
(Aminotran_4) 		4 LEU A  71
TRP A  92
TYR A  19
VAL A  53
 None
 1.15A 1ibgH-4pbcA:
undetectable		 1ibgH-4pbcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		4 LEU A 222
TRP A 217
PHE A  49
TYR A 101
 None
PYR  A 402 ( 4.1A)
PYR  A 402 (-4.2A)
None
 1.32A 1ibgH-4petA:
undetectable		 1ibgH-4petA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qc8 VP2

(Ungulate
bocaparvovirus
1) 		PF00740
(Parvo_coat) 		4 LEU A 117
TRP A 114
PHE A 124
VAL A 484
 None
 1.33A 1ibgH-4qc8A:
undetectable		 1ibgH-4qc8A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 LEU A 673
PHE A 652
TYR A 636
VAL A 695
 None
 0.76A 1ibgH-4r04A:
undetectable		 1ibgH-4r04A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		4 LEU A 251
TRP A 249
PHE A 277
VAL A 273
 None
 0.94A 1ibgH-4r27A:
undetectable		 1ibgH-4r27A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		4 HIS A 267
LEU A 271
PHE A 234
VAL A 231
 None
 1.24A 1ibgH-4r33A:
undetectable		 1ibgH-4r33A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r81 NADH DEHYDROGENASE

(Methanothermobacter
marburgensis) 		PF02525
(Flavodoxin_2) 		4 LEU A  97
TRP A 100
PHE A  84
VAL A 129
 None
 0.90A 1ibgH-4r81A:
undetectable		 1ibgH-4r81A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tm5 D-AMINO ACID
AMINOTRANSFERASE

(Burkholderia
thailandensis) 		PF01063
(Aminotran_4) 		4 LEU A  63
TRP A  84
TYR A  11
VAL A  45
 None
 1.04A 1ibgH-4tm5A:
undetectable		 1ibgH-4tm5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		4 LEU A  64
PHE A  11
TYR A 259
VAL A  32
 None
 1.24A 1ibgH-4udnA:
undetectable		 1ibgH-4udnA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 344
PHE A 323
TYR A 120
VAL A   4
 None
 1.24A 1ibgH-4uekA:
undetectable		 1ibgH-4uekA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 LEU A 280
PHE A 316
TYR A 341
VAL A 348
 None
 0.96A 1ibgH-4uwaA:
undetectable		 1ibgH-4uwaA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9

(Drosophila
melanogaster) 		PF07679
(I-set) 		4 HIS A 186
LEU A 188
PHE A 134
VAL A 135
 None
 1.09A 1ibgH-4x9fA:
8.9		 1ibgH-4x9fA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl1 DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		4 LEU B  62
PHE B  30
TYR B 169
VAL B 173
 MLY  B  63 ( 3.6A)
None
None
None
 1.32A 1ibgH-4xl1B:
undetectable		 1ibgH-4xl1B:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF06253
(MTTB) 		4 LEU A 313
PHE A 387
TYR A 140
VAL A 135
 None
 1.33A 1ibgH-4yycA:
undetectable		 1ibgH-4yycA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I, RESTRICTION
SUBUNIT

(Escherichia
coli) 		PF04851
(ResIII) 		4 HIS C 135
LEU C   7
PHE C 136
TYR C  94
 None
 1.14A 1ibgH-4zcfC:
undetectable		 1ibgH-4zcfC:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 LEU A 145
PHE A 126
TYR A 424
VAL A 429
 None
 1.04A 1ibgH-4zzqA:
undetectable		 1ibgH-4zzqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd2 ENDO-1,4-D-GLUCANASE

(Aliivibrio
fischeri) 		PF01270
(Glyco_hydro_8) 		4 LEU A 271
PHE A 366
TYR A 143
VAL A 362
 None
 1.20A 1ibgH-5cd2A:
undetectable		 1ibgH-5cd2A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Pseudoalteromonas
atlantica) 		PF03480
(DctP) 		4 LEU A 216
TRP A 211
PHE A  43
TYR A  95
 None
None
PYR  A 401 ( 4.2A)
PYR  A 401 (-4.6A)
 1.30A 1ibgH-5cm6A:
undetectable		 1ibgH-5cm6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 5 LEU A 168
TRP A  47
PHE A 136
TYR A  99
VAL A 134
 None
 1.45A 1ibgH-5e4mA:
undetectable		 1ibgH-5e4mA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efv PHI ETA ORF 56-LIKE
PROTEIN

(Staphylococcus
virus 11) 		no annotation 4 LEU A 156
PHE A 167
TYR A 342
VAL A 169
 None
 1.23A 1ibgH-5efvA:
undetectable		 1ibgH-5efvA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 LEU A 551
TRP A 529
PHE A 525
VAL A 522
 None
 1.02A 1ibgH-5f15A:
undetectable		 1ibgH-5f15A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		4 HIS A 553
LEU A 551
PHE A 525
VAL A 299
 None
 1.34A 1ibgH-5fn4A:
undetectable		 1ibgH-5fn4A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 HIS C 304
LEU C 289
TYR C 717
VAL C 320
 None
 1.33A 1ibgH-5g5gC:
undetectable		 1ibgH-5g5gC:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU B 623
TRP B 441
PHE B 613
VAL B 586
 None
 1.28A 1ibgH-5l3qB:
undetectable		 1ibgH-5l3qB:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 580
PHE A 654
TYR A 657
VAL A 652
 None
 1.23A 1ibgH-5l56A:
3.5		 1ibgH-5l56A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lva NAD(P)H-FMN
OXIDOREDUCTASE

(Bacillus
subtilis) 		PF02525
(Flavodoxin_2) 		4 LEU A  75
TRP A  78
PHE A  62
VAL A 103
 None
 0.92A 1ibgH-5lvaA:
undetectable		 1ibgH-5lvaA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PUTATIVE PRE-MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		PF08084
(PROCT) 		4 LEU B2136
TRP B2180
PHE B2100
VAL B2121
 None
 1.28A 1ibgH-5m59B:
undetectable		 1ibgH-5m59B:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ode GLL2934 PROTEIN

(Gloeobacter
violaceus) 		no annotation 4 LEU A  42
PHE A 116
TYR A 106
VAL A 102
 None
 1.09A 1ibgH-5odeA:
undetectable		 1ibgH-5odeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 LEU 7 189
TRP 7 192
PHE 7 158
VAL 7 164
 None
 1.29A 1ibgH-5oom7:
undetectable		 1ibgH-5oom7:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 4 LEU A 426
PHE A 326
TYR A 360
VAL A 356
 None
 1.25A 1ibgH-5vaeA:
undetectable		 1ibgH-5vaeA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		4 HIS A 176
LEU A 180
PHE A 179
VAL A 167
 None
 1.26A 1ibgH-5xsyA:
undetectable		 1ibgH-5xsyA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xx9 BACTERIOFERRITIN

(Streptomyces
coelicolor) 		no annotation 4 LEU A 138
PHE A  87
TYR A  43
VAL A  83
 None
 1.15A 1ibgH-5xx9A:
undetectable		 1ibgH-5xx9A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 4 LEU A 288
PHE A 376
TYR A 261
VAL A 372
 None
 1.23A 1ibgH-6cipA:
undetectable		 1ibgH-6cipA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 4 HIS A 244
LEU A 240
TYR A 290
VAL A 174
 None
 1.23A 1ibgH-6ercA:
undetectable		 1ibgH-6ercA:
16.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ai1 IGG1-KAPPA 59.1 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H  73
SER H  74
SER H  70
ARG H  71
 None
 1.16A 1ibgL-1ai1H:
14.4		 1ibgL-1ai1H:
31.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		4 THR A  19
SER A  22
SER A  76
LEU A 104
 None
 1.17A 1ibgL-1c9wA:
0.0		 1ibgL-1c9wA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evs ONCOSTATIN M

(Homo sapiens) 		PF01291
(LIF_OSM) 		4 HIS A 178
SER A 179
ARG A 182
LEU A  62
 None
 1.16A 1ibgL-1evsA:
undetectable		 1ibgL-1evsA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 SER A 290
HIS A 173
ARG A 172
LEU A 166
 None
 0.93A 1ibgL-1ewrA:
0.0		 1ibgL-1ewrA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnz BARK AGGLUTININ I,
POLYPEPTIDE A

(Robinia
pseudoacacia) 		PF00139
(Lectin_legB) 		4 THR A  85
ARG A 139
TYR A 183
LEU A 181
 None
 1.15A 1ibgL-1fnzA:
1.1		 1ibgL-1fnzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 THR A 338
SER A 339
TYR A 395
LEU A 403
 None
 1.09A 1ibgL-1gl6A:
0.0		 1ibgL-1gl6A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		4 THR A 244
SER A 237
TYR A  39
LEU A  36
 None
MES  A1000 (-2.7A)
None
None
 1.16A 1ibgL-1hzoA:
0.0		 1ibgL-1hzoA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 THR A  63
SER A  62
HIS A 345
LEU A 348
 None
None
HEM  A 430 (-3.8A)
HEM  A 430 ( 4.4A)
 1.10A 1ibgL-1lgfA:
0.0		 1ibgL-1lgfA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 SER A 290
HIS A 173
ARG A 172
LEU A 166
 None
 0.99A 1ibgL-1nneA:
0.5		 1ibgL-1nneA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP2)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 THR 2  43
SER 2  42
HIS 2 209
TYR 2  98
LEU 2  94
 None
 1.32A 1ibgL-1qgc2:
0.0		 1ibgL-1qgc2:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxq YFIT

(Bacillus
subtilis) 		PF12867
(DinB_2) 		4 SER A 110
HIS A  66
SER A 104
ARG A  62
 None
 1.07A 1ibgL-1rxqA:
undetectable		 1ibgL-1rxqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE
SULFATE
ADENYLYLTRANSFERASE
SUBUNIT 2

(Pseudomonas
syringae;
Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU)
PF01507
(PAPS_reduct) 		4 THR B 127
SER B 126
ARG B  26
LEU A   5
 None
 1.12A 1ibgL-1zunB:
undetectable		 1ibgL-1zunB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctr DNAJ HOMOLOG
SUBFAMILY B MEMBER 9

(Homo sapiens) 		PF00226
(DnaJ) 		4 THR A  77
SER A  78
TYR A  10
LEU A  59
 None
 1.13A 1ibgL-2ctrA:
undetectable		 1ibgL-2ctrA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8j FYN-RELATED KINASE

(Mus musculus) 		PF00018
(SH3_1) 		4 THR A  37
SER A  38
TYR A   9
LEU A  48
 None
 1.00A 1ibgL-2d8jA:
undetectable		 1ibgL-2d8jA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2duw PUTATIVE COA-BINDING
PROTEIN

(Klebsiella
pneumoniae) 		PF13380
(CoA_binding_2) 		4 THR A  97
SER A 119
TYR A  41
LEU A  36
 None
 0.90A 1ibgL-2duwA:
undetectable		 1ibgL-2duwA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gl7 B-CELL LYMPHOMA 9
PROTEIN

(Homo sapiens) 		PF11502
(BCL9) 		4 SER C 352
SER C 362
ARG C 359
LEU C 366
 None
 1.17A 1ibgL-2gl7C:
undetectable		 1ibgL-2gl7C:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hes YDR267CP

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 SER X  19
HIS X 158
SER X 203
LEU X 214
 None
 1.16A 1ibgL-2hesX:
undetectable		 1ibgL-2hesX:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8a POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00645
(zf-PARP) 		4 SER A   4
ARG A  10
TYR A  13
LEU A  33
 None
 0.99A 1ibgL-2n8aA:
undetectable		 1ibgL-2n8aA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 THR A 136
SER A 135
ARG A 181
TYR A 178
 None
 1.12A 1ibgL-2okjA:
undetectable		 1ibgL-2okjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		4 THR A 236
SER A 237
ARG A 208
LEU A  65
 None
 1.15A 1ibgL-2oy0A:
undetectable		 1ibgL-2oy0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px5 ENVELOPE PROTEIN M
(MATRIX PROTEIN)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]
GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		4 THR A 236
SER A 237
ARG A 208
LEU A  65
 None
 1.08A 1ibgL-2px5A:
undetectable		 1ibgL-2px5A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		4 THR A 259
SER A 258
SER A 313
TYR A 123
 None
 1.04A 1ibgL-2xxlA:
undetectable		 1ibgL-2xxlA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 THR A   6
SER A  28
HIS A  72
LEU A 145
 None
 1.12A 1ibgL-2yutA:
undetectable		 1ibgL-2yutA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu CROSSOVER JUNCTION
ENDONUCLEASE EME1
MUS81 PROTEIN

(Danio rerio;
Homo sapiens) 		PF02732
(ERCC4) 		4 THR A 560
SER A 559
TYR B 514
LEU B 510
 None
 1.06A 1ibgL-2ziuA:
undetectable		 1ibgL-2ziuA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE
DNA POLYMERASE
SLIDING CLAMP

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
PF03104
(DNA_pol_B_exo1) 		4 THR A 767
SER A 768
SER B  44
ARG B  45
 None
 1.00A 1ibgL-3a2fA:
undetectable		 1ibgL-3a2fA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		4 HIS A 223
SER A 214
ARG A 215
LEU A 427
 None
 1.06A 1ibgL-3bzmA:
undetectable		 1ibgL-3bzmA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e99 BENZOATE
1,2-DIOXYGENASE BETA
SUBUNIT

(Burkholderia
mallei) 		PF00866
(Ring_hydroxyl_B) 		4 THR A  89
SER A 116
HIS A  91
SER A  17
 None
 1.09A 1ibgL-3e99A:
undetectable		 1ibgL-3e99A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eni BACTERIOCHLOROPHYLL
A PROTEIN

(Chlorobaculum
tepidum) 		PF02327
(BChl_A) 		4 SER A 117
SER A 220
ARG A 221
LEU A 207
 None
BCL  A 371 ( 3.8A)
None
None
 1.08A 1ibgL-3eniA:
undetectable		 1ibgL-3eniA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		4 SER A 356
ARG A 355
TYR A 354
LEU A 357
 None
 1.14A 1ibgL-3fddA:
undetectable		 1ibgL-3fddA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 SER A 428
ARG A 419
TYR A 290
LEU A 304
 None
 0.99A 1ibgL-3g2fA:
undetectable		 1ibgL-3g2fA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		4 THR A 176
HIS A 207
SER A 219
LEU A 225
 None
 1.11A 1ibgL-3gs6A:
undetectable		 1ibgL-3gs6A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		4 HIS A 241
SER A 232
ARG A 233
LEU A 445
 None
 1.04A 1ibgL-3gseA:
undetectable		 1ibgL-3gseA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrv TOXIN COREGULATED
PILIN

(Vibrio cholerae) 		PF05946
(TcpA) 		4 SER A  53
ARG A  52
TYR A  51
LEU A  54
 None
GOL  A1002 (-3.1A)
None
None
 1.11A 1ibgL-3hrvA:
undetectable		 1ibgL-3hrvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k94 THIAMIN
PYROPHOSPHOKINASE

(Geobacillus
thermodenitrificans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 THR A 183
SER A 182
SER A 187
TYR A 171
 None
None
CSO  A 185 ( 3.2A)
None
 1.00A 1ibgL-3k94A:
undetectable		 1ibgL-3k94A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6n METALLO-BETA-LACTAMA
SE

(Chryseobacterium
indologenes) 		PF00753
(Lactamase_B) 		4 HIS A  85
ARG A  84
TYR A  38
LEU A  77
 None
 1.16A 1ibgL-3l6nA:
undetectable		 1ibgL-3l6nA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		4 THR A 236
SER A 237
ARG A 208
LEU A  65
 None
 1.16A 1ibgL-3lkzA:
undetectable		 1ibgL-3lkzA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		4 THR A 432
SER A 433
HIS A 408
TYR A 322
 None
None
None
GOL  A   8 ( 4.9A)
 0.99A 1ibgL-3m1uA:
undetectable		 1ibgL-3m1uA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mj8 STIMULATORY HAMSTER
ANTIBODY HL4E10 FAB
HEAVY CHAIN

(Cricetulus
migratorius) 		no annotation 4 THR H  73
SER H  74
SER H  70
ARG H  71
 None
 1.14A 1ibgL-3mj8H:
17.0		 1ibgL-3mj8H:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		4 THR K 110
SER K 111
SER K  97
LEU K  87
 None
 1.08A 1ibgL-3mvdK:
undetectable		 1ibgL-3mvdK:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		4 THR A 187
SER A 186
TYR A 175
LEU A 279
 None
 1.02A 1ibgL-3omnA:
undetectable		 1ibgL-3omnA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 SER A 597
HIS A 629
SER A 624
TYR A 586
 None
 0.70A 1ibgL-3opyA:
undetectable		 1ibgL-3opyA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orf DIHYDROPTERIDINE
REDUCTASE

(Dictyostelium
discoideum) 		PF00106
(adh_short) 		4 THR A 132
SER A 133
SER A 126
LEU A 169
 None
 1.16A 1ibgL-3orfA:
undetectable		 1ibgL-3orfA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6z POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		4 SER A 838
HIS A 879
TYR A 911
LEU A 907
 None
 0.99A 1ibgL-3q6zA:
undetectable		 1ibgL-3q6zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj3 CATHEPSIN L-LIKE
PROTEIN

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 SER A 288
SER A 249
TYR A  56
LEU A  58
 None
 1.05A 1ibgL-3qj3A:
undetectable		 1ibgL-3qj3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT

(Cryptococcus
neoformans) 		PF01239
(PPTA) 		4 THR A  85
SER A  86
ARG A 121
LEU A 116
 None
 1.03A 1ibgL-3sfyA:
undetectable		 1ibgL-3sfyA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stt METHYLKETONE
SYNTHASE I

(Solanum
habrochaites) 		PF12697
(Abhydrolase_6) 		4 THR A  18
HIS A  86
SER A 111
LEU A 223
 DKA  A 266 (-2.9A)
None
None
None
 0.98A 1ibgL-3sttA:
undetectable		 1ibgL-3sttA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 THR A 159
SER A 160
TYR A 231
LEU A 221
 None
 1.00A 1ibgL-3syjA:
undetectable		 1ibgL-3syjA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdp FORMATE/NITRITE
TRANSPORTER

(Clostridioides
difficile) 		PF01226
(Form_Nir_trans) 		4 THR A 104
SER A 105
TYR A 250
LEU A   6
 None
BOG  A 267 (-2.8A)
None
None
 1.03A 1ibgL-3tdpA:
undetectable		 1ibgL-3tdpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		4 THR A 386
SER A 385
TYR A 352
LEU A 494
 None
None
GOL  A 721 (-3.6A)
None
 1.12A 1ibgL-3ucqA:
undetectable		 1ibgL-3ucqA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		4 THR A 435
SER A 428
HIS A 412
LEU A 343
 None
 1.09A 1ibgL-3ujzA:
4.5		 1ibgL-3ujzA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		4 SER A 396
SER A 533
TYR A 556
LEU A 530
 None
 1.10A 1ibgL-3vgfA:
5.4		 1ibgL-3vgfA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 THR A 273
SER A 272
SER A 239
ARG A 240
 None
 1.16A 1ibgL-3wnpA:
6.4		 1ibgL-3wnpA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzi ACETYLGLUTAMATE
KINASE

(Saccharomyces
cerevisiae) 		PF00696
(AA_kinase)
PF04768
(NAT) 		5 THR A  70
SER A  69
HIS A 125
TYR A 129
LEU A 231
 None
 1.43A 1ibgL-3zziA:
undetectable		 1ibgL-3zziA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0u TAIL FIBER PROTEIN

(Escherichia
virus T7) 		PF12604
(gp37_C) 		4 THR A 418
HIS A 411
TYR A 385
LEU A 387
 None
 1.08A 1ibgL-4a0uA:
undetectable		 1ibgL-4a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ani PROTEIN GRPE

(Geobacillus
kaustophilus) 		PF01025
(GrpE) 		4 SER A 148
ARG A 147
TYR A 146
LEU A 149
 None
 1.05A 1ibgL-4aniA:
undetectable		 1ibgL-4aniA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 THR A 187
SER A 401
ARG A 188
LEU A  36
 None
 1.15A 1ibgL-4c9mA:
undetectable		 1ibgL-4c9mA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb0 LCC

(uncultured
bacterium) 		PF12695
(Abhydrolase_5) 		4 THR A 144
SER A 145
ARG A 143
LEU A 181
 SCN  A 303 (-4.7A)
SCN  A 303 (-2.7A)
None
None
 0.94A 1ibgL-4eb0A:
undetectable		 1ibgL-4eb0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02759
(RUN) 		4 THR A  97
SER A  99
SER A  90
LEU A 146
 None
 1.04A 1ibgL-4giwA:
undetectable		 1ibgL-4giwA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4goq HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF07372
(DUF1491) 		4 THR A  55
SER A  52
ARG A  61
LEU A  37
 None
None
GOL  A 202 (-4.3A)
None
 0.88A 1ibgL-4goqA:
undetectable		 1ibgL-4goqA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 THR A 236
SER A 237
ARG A 208
LEU A  65
 None
 1.14A 1ibgL-4k6mA:
undetectable		 1ibgL-4k6mA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Salmonella
enterica) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 THR A  11
SER A  10
HIS A 110
LEU A 140
 GSH  A 301 ( 4.4A)
GSH  A 301 (-2.5A)
None
None
 1.15A 1ibgL-4kh7A:
undetectable		 1ibgL-4kh7A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 SER A 378
ARG A 377
TYR A 259
LEU A 380
 None
None
ACT  A 602 (-4.3A)
None
 1.02A 1ibgL-4l7tA:
undetectable		 1ibgL-4l7tA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 SER A 374
SER A 330
TYR A 410
LEU A 290
 None
 1.13A 1ibgL-4l87A:
undetectable		 1ibgL-4l87A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH

(Lechevalieria
aerocolonigenes) 		PF04820
(Trp_halogenase) 		4 SER A 358
HIS A 170
SER A  77
LEU A 524
 None
 1.17A 1ibgL-4lu6A:
undetectable		 1ibgL-4lu6A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		4 SER B 463
HIS B 495
TYR B 204
LEU B 208
 None
None
FPP  B 601 ( 4.9A)
None
 1.15A 1ibgL-4mbgB:
undetectable		 1ibgL-4mbgB:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbr SERINE-RICH REPEAT
PROTEIN 2

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		4 SER A 262
HIS A 529
SER A 395
ARG A 396
 None
 0.99A 1ibgL-4mbrA:
5.8		 1ibgL-4mbrA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 HIS A 558
ARG A 556
TYR A 391
LEU A 428
 None
 1.09A 1ibgL-4p08A:
undetectable		 1ibgL-4p08A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcg VP1

(Human
polyomavirus 6) 		PF00718
(Polyoma_coat) 		4 SER A 212
SER A 267
ARG A 270
TYR A 266
 None
 1.16A 1ibgL-4pcgA:
undetectable		 1ibgL-4pcgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn0 UPF0141 PROTEIN YJDB

(Campylobacter
jejuni) 		PF00884
(Sulfatase) 		4 SER A 327
ARG A 365
TYR A 394
LEU A 398
 None
 1.09A 1ibgL-4tn0A:
undetectable		 1ibgL-4tn0A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00144
(Beta-lactamase) 		4 THR A 313
ARG A 346
TYR A  23
LEU A  19
 PO4  A 401 (-4.0A)
None
None
None
 1.14A 1ibgL-4u0tA:
undetectable		 1ibgL-4u0tA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		4 THR E 373
SER E 372
HIS E 337
LEU E 442
 None
 1.07A 1ibgL-4xgcE:
undetectable		 1ibgL-4xgcE:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnv P2Y PURINOCEPTOR 1,
RUBREDOXIN, P2Y
PURINOCEPTOR 1

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		4 SER A  87
HIS A 148
SER A 151
ARG A 149
 None
Y01  A1104 (-3.8A)
Y01  A1104 ( 3.9A)
None
 1.08A 1ibgL-4xnvA:
undetectable		 1ibgL-4xnvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 THR A 169
SER A 168
TYR A 143
LEU A 217
 None
 0.89A 1ibgL-4yj1A:
undetectable		 1ibgL-4yj1A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 THR A 354
SER A 378
SER A 308
TYR A 282
 None
 0.61A 1ibgL-4z61A:
undetectable		 1ibgL-4z61A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP1
VP2
VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 SER 1 127
HIS 1 123
SER 3 167
TYR 2 100
 None
 0.96A 1ibgL-5aca1:
undetectable		 1ibgL-5aca1:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)

(Homo sapiens) 		PF07686
(V-set) 		5 THR A  31
SER A  32
SER A  95
ARG A  96
LEU A 100
 None
 0.66A 1ibgL-5b8cA:
22.9		 1ibgL-5b8cA:
42.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 THR A 216
SER A 215
TYR A 273
LEU A  53
 None
 1.11A 1ibgL-5cwaA:
2.5		 1ibgL-5cwaA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 THR A 476
SER A 475
ARG A 477
LEU A 378
 None
 1.11A 1ibgL-5dmyA:
6.1		 1ibgL-5dmyA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2h BETA-LACTAMASE

(Mycolicibacterium
smegmatis) 		PF00144
(Beta-lactamase) 		4 THR A 308
ARG A 341
TYR A  17
LEU A  13
 None
 1.07A 1ibgL-5e2hA:
undetectable		 1ibgL-5e2hA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 4 THR C  63
SER C  62
HIS C 345
LEU C 348
 None
None
HEM  C 502 (-3.6A)
HEM  C 502 ( 4.3A)
 1.14A 1ibgL-5ex6C:
undetectable		 1ibgL-5ex6C:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezo C12 FAB

(Plasmodium
falciparum) 		no annotation 4 SER A 201
ARG A 135
TYR A 144
LEU A  93
 None
 1.16A 1ibgL-5ezoA:
undetectable		 1ibgL-5ezoA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh8 PROBABLE CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		4 THR A  84
SER A  85
TYR A 159
LEU A 164
 None
 1.10A 1ibgL-5jh8A:
undetectable		 1ibgL-5jh8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 4 SER A 589
HIS A 594
ARG A 562
TYR A 582
 NAG  A 904 ( 4.7A)
None
None
None
 1.11A 1ibgL-5mhfA:
2.0		 1ibgL-5mhfA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 4 THR A 236
SER A 237
ARG A 208
LEU A  65
 None
 1.07A 1ibgL-5njuA:
undetectable		 1ibgL-5njuA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usc PREPHENATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF02153
(PDH) 		4 THR A 194
HIS A 190
TYR A 155
LEU A 157
 None
 1.07A 1ibgL-5uscA:
undetectable		 1ibgL-5uscA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whr INDOLEAMINE
2,3-DIOXYGENASE 1

(Homo sapiens) 		no annotation 5 THR A 395
SER A 398
SER A 341
ARG A 343
LEU A 211
 None
None
None
HEM  A 501 (-3.9A)
None
 1.44A 1ibgL-5whrA:
undetectable		 1ibgL-5whrA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whr INDOLEAMINE
2,3-DIOXYGENASE 1

(Homo sapiens) 		no annotation 4 THR A 395
SER A 398
SER A 344
ARG A 343
 None
None
None
HEM  A 501 (-3.9A)
 1.17A 1ibgL-5whrA:
undetectable		 1ibgL-5whrA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 SER A  71
SER A 130
ARG A 133
LEU A 211
 OLA  A1207 (-3.2A)
None
PO4  A1205 (-2.5A)
None
 1.13A 1ibgL-5wivA:
undetectable		 1ibgL-5wivA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		4 THR A 572
ARG A 531
TYR A 626
LEU A 543
 None
 1.11A 1ibgL-5wzrA:
undetectable		 1ibgL-5wzrA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6) 		4 THR C  18
HIS C  28
TYR D 130
LEU D 126
 None
 1.03A 1ibgL-5xfaC:
undetectable		 1ibgL-5xfaC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 THR A 407
SER A 406
TYR A1526
LEU A1525
 None
 0.99A 1ibgL-5xyaA:
2.9		 1ibgL-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 THR C 481
SER C 480
TYR C 565
LEU C 564
 None
 1.13A 1ibgL-5y3rC:
undetectable		 1ibgL-5y3rC:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zc3 -

(-) 		no annotation 4 THR B 432
SER B 431
TYR B 414
LEU B 410
 None
 0.87A 1ibgL-5zc3B:
undetectable		 1ibgL-5zc3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znp SHORT LIFE FAMILY
PROTEIN

(Populus
trichocarpa) 		no annotation 4 SER A  50
ARG A  58
TYR A  14
LEU A  11
 None
 1.11A 1ibgL-5znpA:
undetectable		 1ibgL-5znpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE

(Arabidopsis
thaliana) 		no annotation 4 THR A 557
SER A 560
ARG A 559
LEU A 432
 None
 1.15A 1ibgL-6avhA:
undetectable		 1ibgL-6avhA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3

(Homo sapiens) 		no annotation 4 THR A 662
SER A 665
ARG A 664
LEU A 651
 None
 1.11A 1ibgL-6cvzA:
undetectable		 1ibgL-6cvzA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dch SCOE PROTEIN

(Streptomyces
coeruleorubidus) 		no annotation 4 HIS A 225
SER A 292
ARG A 291
LEU A 293
 None
 1.10A 1ibgL-6dchA:
undetectable		 1ibgL-6dchA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))

(Escherichia
coli) 		no annotation 4 THR A 293
SER A 294
HIS A 160
SER A 289
 None
 1.17A 1ibgL-6dkhA:
undetectable		 1ibgL-6dkhA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ejg SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 4 THR C  69
SER C  70
SER C 133
ARG C 134
 None
 0.75A 1ibgL-6ejgC:
22.7		 1ibgL-6ejgC:
91.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 4 THR A  63
SER A  62
HIS A 345
LEU A 348
 None
None
HEM  A 401 (-3.5A)
HEM  A 401 ( 4.5A)
 0.99A 1ibgL-6fshA:
undetectable		 1ibgL-6fshA:
16.82