SIMILAR PATTERNS OF AMINO ACIDS FOR 1I9G_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dot DUCK OVOTRANSFERRIN

(Anas
platyrhynchos) 		PF00405
(Transferrin) 		3 GLU A  80
HIS A 250
ASP A 302
 None
FE  A 687 (-3.2A)
None
 0.79A 1i9gA-1dotA:
undetectable		 1i9gA-1dotA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 GLU A 188
HIS A 190
ASP A 176
 None
 0.82A 1i9gA-1eovA:
undetectable		 1i9gA-1eovA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		3 GLU A  80
HIS A 253
ASP A 302
 None
 0.83A 1i9gA-1i6qA:
undetectable		 1i9gA-1i6qA:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		3 GLU A 131
HIS A 136
ASP A 178
 SAM  A 301 (-2.6A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
 0.00A 1i9gA-1i9gA:
42.1		 1i9gA-1i9gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 GLU A 413
HIS A 597
ASP A 645
 None
FE  A 694 ( 3.6A)
None
 0.87A 1i9gA-1n76A:
undetectable		 1i9gA-1n76A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE

(Pyrococcus
furiosus) 		PF00152
(tRNA-synt_2) 		3 GLU A 101
HIS A 110
ASP A  52
 None
 0.79A 1i9gA-1nnhA:
undetectable		 1i9gA-1nnhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 GLU A  80
HIS A 250
ASP A 302
 None
FE  A 333 ( 3.5A)
None
 0.78A 1i9gA-1nntA:
undetectable		 1i9gA-1nntA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		3 GLU A 262
HIS A 146
ASP A 333
 None
 0.85A 1i9gA-1tjyA:
5.4		 1i9gA-1tjyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3

(Bos taurus) 		PF00022
(Actin) 		3 GLU A 280
HIS A 284
ASP A 237
 None
 0.85A 1i9gA-1u2vA:
undetectable		 1i9gA-1u2vA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		3 GLU A 115
HIS A 110
ASP A 913
 None
 0.76A 1i9gA-1uf2A:
undetectable		 1i9gA-1uf2A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		3 GLU A 121
HIS A 137
ASP A 146
 MN  A1238 (-2.7A)
MN  A1238 (-3.5A)
None
 0.87A 1i9gA-1v6mA:
undetectable		 1i9gA-1v6mA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1b CRTF-RELATED PROTEIN

(Chlorobaculum
tepidum) 		PF00891
(Methyltransf_2) 		3 GLU A 147
HIS A 150
ASP A 175
 SAH  A4261 (-2.7A)
SAH  A4261 (-3.6A)
None
 0.85A 1i9gA-1x1bA:
12.9		 1i9gA-1x1bA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		3 GLU A 346
HIS A 403
ASP A 299
 None
 0.78A 1i9gA-1x3lA:
4.8		 1i9gA-1x3lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		3 GLU A  78
HIS A  77
ASP A 427
 None
 0.50A 1i9gA-1z6tA:
undetectable		 1i9gA-1z6tA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoq INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		3 GLU A 310
HIS A 290
ASP A 314
 None
 0.69A 1i9gA-1zoqA:
undetectable		 1i9gA-1zoqA:
23.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		3 GLU A 135
HIS A 140
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-4.0A)
SAM  A 601 (-3.5A)
 0.19A 1i9gA-2b25A:
25.8		 1i9gA-2b25A:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 GLU X 425
HIS X 424
ASP X 432
 None
 0.85A 1i9gA-2b5dX:
undetectable		 1i9gA-2b5dX:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 GLU A  80
HIS A 250
ASP A 302
 None
AL  A 687 ( 3.3A)
None
 0.84A 1i9gA-2d3iA:
undetectable		 1i9gA-2d3iA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		3 GLU A 391
HIS A 356
ASP A 416
 None
ZN  A 601 (-3.3A)
None
 0.73A 1i9gA-2h1nA:
undetectable		 1i9gA-2h1nA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 GLU A 222
HIS A 219
ASP A 112
 None
 0.89A 1i9gA-2i3aA:
3.6		 1i9gA-2i3aA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		3 GLU A 510
HIS A 474
ASP A 467
 None
ZN  A 679 (-3.4A)
None
 0.88A 1i9gA-2o3eA:
undetectable		 1i9gA-2o3eA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		3 GLU A  52
HIS A  50
ASP A 102
 None
 0.77A 1i9gA-2o7pA:
2.1		 1i9gA-2o7pA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 340
HIS A 342
ASP A 288
 None
 0.73A 1i9gA-2ox4A:
undetectable		 1i9gA-2ox4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p11 HYPOTHETICAL PROTEIN

(Paraburkholderia
xenovorans) 		no annotation 3 GLU A 148
HIS A 146
ASP A  16
 None
 0.85A 1i9gA-2p11A:
2.1		 1i9gA-2p11A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Arabidopsis
thaliana) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 GLU A 227
HIS A 224
ASP A 114
 None
 0.81A 1i9gA-2q49A:
3.4		 1i9gA-2q49A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 GLU A 230
HIS A 233
ASP A 167
 ZN  A 431 ( 4.0A)
ZN  A 431 (-3.3A)
None
 0.81A 1i9gA-2qn0A:
undetectable		 1i9gA-2qn0A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
halodurans) 		PF00268
(Ribonuc_red_sm) 		3 GLU A 185
HIS A 222
ASP A  93
 None
 0.81A 1i9gA-2rccA:
undetectable		 1i9gA-2rccA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl3 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus sp.
DK17) 		PF00903
(Glyoxalase) 		3 GLU A 263
HIS A 212
ASP A 281
 FE  A1289 (-2.7A)
FE  A1289 (-3.6A)
None
 0.77A 1i9gA-2wl3A:
undetectable		 1i9gA-2wl3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		3 GLU A  85
HIS A  87
ASP A 251
 None
FUC  A1591 (-4.0A)
None
 0.82A 1i9gA-2wmhA:
undetectable		 1i9gA-2wmhA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 GLU A  15
HIS A  12
ASP A  26
 None
 0.78A 1i9gA-2xr1A:
3.2		 1i9gA-2xr1A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a77 INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		3 GLU A 310
HIS A 290
ASP A 314
 None
 0.73A 1i9gA-3a77A:
undetectable		 1i9gA-3a77A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ago RIBONUCLEASE U2

(Ustilago
sphaerogena) 		PF00545
(Ribonuclease) 		3 GLU A  62
HIS A  41
ASP A 108
 3AM  A 115 (-2.9A)
3AM  A 115 (-3.8A)
3AM  A 115 (-2.9A)
 0.68A 1i9gA-3agoA:
undetectable		 1i9gA-3agoA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 3 GLU A 391
HIS A 356
ASP A 416
 None
ZN  A 565 (-3.4A)
None
 0.78A 1i9gA-3ahmA:
undetectable		 1i9gA-3ahmA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6a TERMINASE LARGE
SUBUNIT

(Escherichia
virus RB49) 		PF17289
(Terminase_6C) 		3 GLU A 519
HIS A 537
ASP A 398
 None
None
MG  A   1 (-3.1A)
 0.84A 1i9gA-3c6aA:
undetectable		 1i9gA-3c6aA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695

(Pyrococcus
furiosus) 		PF01814
(Hemerythrin)
PF13596
(PAS_10) 		3 GLU A 304
HIS A 301
ASP A 344
 None
 0.80A 1i9gA-3caxA:
undetectable		 1i9gA-3caxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		3 GLU A 299
HIS A 421
ASP A 245
 None
 0.77A 1i9gA-3cc1A:
undetectable		 1i9gA-3cc1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 GLU A  88
HIS A  30
ASP A  15
 None
 0.64A 1i9gA-3d6bA:
undetectable		 1i9gA-3d6bA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 GLU A 234
HIS A 237
ASP A 296
 None
 0.86A 1i9gA-3decA:
2.4		 1i9gA-3decA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2v 3'-5'-EXONUCLEASE

(Saccharomyces
cerevisiae) 		PF01026
(TatD_DNase) 		3 GLU A 185
HIS A 114
ASP A  47
 MG  A 427 ( 4.5A)
None
None
 0.85A 1i9gA-3e2vA:
undetectable		 1i9gA-3e2vA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLU A 398
HIS A 432
ASP A 385
 None
 0.88A 1i9gA-3etcA:
undetectable		 1i9gA-3etcA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gw4 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		PF13424
(TPR_12) 		3 GLU A  93
HIS A  71
ASP A 103
 None
 0.53A 1i9gA-3gw4A:
undetectable		 1i9gA-3gw4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		3 GLU A 194
HIS A 231
ASP A 100
 FE  A 401 (-2.5A)
FE  A 401 (-3.2A)
None
 0.73A 1i9gA-3hf1A:
undetectable		 1i9gA-3hf1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		3 GLU A 228
HIS A 231
ASP A 100
 FE  A 401 (-2.9A)
FE  A 401 (-3.2A)
None
 0.79A 1i9gA-3hf1A:
undetectable		 1i9gA-3hf1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		3 GLU A 350
HIS A 379
ASP A 337
 None
 0.88A 1i9gA-3ivrA:
3.1		 1i9gA-3ivrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfo NUCLEOPORIN NUP133

(Saccharomyces
cerevisiae) 		no annotation 3 GLU A1012
HIS A1060
ASP A1067
 None
 0.69A 1i9gA-3kfoA:
undetectable		 1i9gA-3kfoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLU A 345
HIS A 378
ASP A 332
 None
 0.78A 1i9gA-3lgxA:
2.2		 1i9gA-3lgxA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		3 GLU A  83
HIS A 249
ASP A 297
 None
 0.81A 1i9gA-3mc2A:
undetectable		 1i9gA-3mc2A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mj9 JUNCTIONAL ADHESION
MOLECULE-LIKE

(Mus musculus) 		PF07686
(V-set) 		3 GLU A  19
HIS A  16
ASP A 198
 None
 0.88A 1i9gA-3mj9A:
undetectable		 1i9gA-3mj9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		3 GLU A 391
HIS A 528
ASP A 466
 MN  A 680 (-3.9A)
None
None
 0.86A 1i9gA-3mwtA:
undetectable		 1i9gA-3mwtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR

(Legionella
pneumophila) 		PF14860
(DrrA_P4M) 		3 GLU A 631
HIS A 496
ASP A 577
 None
 0.85A 1i9gA-3n6oA:
undetectable		 1i9gA-3n6oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		3 GLU A 340
HIS A 348
ASP A 273
 None
 0.74A 1i9gA-3p2cA:
undetectable		 1i9gA-3p2cA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		3 GLU A 101
HIS A 110
ASP A  52
 None
 0.81A 1i9gA-3p8tA:
undetectable		 1i9gA-3p8tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		3 GLU A  92
HIS A  97
ASP A  65
 None
 0.88A 1i9gA-3td9A:
2.9		 1i9gA-3td9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfw PUTATIVE
O-METHYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF01596
(Methyltransf_3) 		3 GLU A  93
HIS A  98
ASP A 141
 None
 0.34A 1i9gA-3tfwA:
19.8		 1i9gA-3tfwA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgq HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 GLU A 106
HIS A 105
ASP A 113
 None
 0.88A 1i9gA-3tgqA:
undetectable		 1i9gA-3tgqA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Bacillus
anthracis) 		PF02525
(Flavodoxin_2) 		3 GLU A 161
HIS A 164
ASP A 154
 None
CL  A 222 (-4.8A)
None
 0.60A 1i9gA-3u7iA:
undetectable		 1i9gA-3u7iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLU A  57
HIS A  60
ASP A 396
 None
 0.78A 1i9gA-3urhA:
2.8		 1i9gA-3urhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 GLU A1567
HIS A1568
ASP A3053
 None
 0.76A 1i9gA-3vkgA:
undetectable		 1i9gA-3vkgA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		3 GLU A 373
HIS A 408
ASP A 360
 None
 0.83A 1i9gA-3wv4A:
undetectable		 1i9gA-3wv4A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP

(Staphylococcus
aureus) 		no annotation 3 GLU A  39
HIS A  24
ASP A  42
 None
 0.76A 1i9gA-4ae5A:
undetectable		 1i9gA-4ae5A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atf BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 GLU A 184
HIS A 215
ASP A 173
 GAL  A1357 (-4.1A)
GAL  A1357 (-3.3A)
GAL  A1357 (-2.8A)
 0.74A 1i9gA-4atfA:
undetectable		 1i9gA-4atfA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A 195
HIS A 201
ASP A  87
 None
None
CK7  A1285 (-4.0A)
 0.87A 1i9gA-4b9dA:
undetectable		 1i9gA-4b9dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bax GLUTAMINE SYNTHETASE

(Streptomyces
coelicolor) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 GLU A 318
HIS A 237
ASP A 298
 None
 0.77A 1i9gA-4baxA:
undetectable		 1i9gA-4baxA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		3 GLU A1008
HIS A 934
ASP A 807
 None
None
J82  A2000 ( 4.9A)
 0.79A 1i9gA-4bfrA:
undetectable		 1i9gA-4bfrA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		3 GLU A 231
HIS A 234
ASP A 239
 None
 0.84A 1i9gA-4bokA:
undetectable		 1i9gA-4bokA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bws THIOREDOXIN-LIKE
PROTEIN 4A

(Homo sapiens) 		PF02966
(DIM1) 		3 GLU A  65
HIS A   9
ASP A  33
 None
 0.81A 1i9gA-4bwsA:
undetectable		 1i9gA-4bwsA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		3 GLU A 461
HIS A 115
ASP A 577
 None
 0.87A 1i9gA-4c3oA:
undetectable		 1i9gA-4c3oA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		3 GLU A 497
HIS A 556
ASP A 481
 None
 0.63A 1i9gA-4czwA:
undetectable		 1i9gA-4czwA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		3 GLU A 413
HIS A 595
ASP A 643
 None
FE  A 701 ( 3.4A)
None
 0.77A 1i9gA-4fimA:
undetectable		 1i9gA-4fimA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 3 GLU A 160
HIS A 157
ASP A  81
 None
 0.76A 1i9gA-4h5yA:
undetectable		 1i9gA-4h5yA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		3 GLU A 273
HIS A 292
ASP A 247
 None
 0.80A 1i9gA-4hy3A:
6.0		 1i9gA-4hy3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		3 GLU A 220
HIS A 218
ASP A 178
 None
 0.89A 1i9gA-4impA:
7.2		 1i9gA-4impA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN

(Mus musculus) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		3 GLU A 186
HIS A 182
ASP A 165
 None
 0.86A 1i9gA-4m4dA:
undetectable		 1i9gA-4m4dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4k HYDROXYLAMINE
OXIDOREDUCTASE

(Candidatus
Kuenenia
stuttgartiensis) 		PF13447
(Multi-haem_cyto) 		3 GLU A 265
HIS A 258
ASP A 262
 HEM  A 613 (-3.6A)
HEM  A 612 (-3.3A)
HOA  A 615 (-2.9A)
 0.74A 1i9gA-4n4kA:
undetectable		 1i9gA-4n4kA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqf NUCLEOTIDYLTRANSFERA
SE

(Agrobacterium
fabrum) 		PF05168
(HEPN) 		3 GLU A 199
HIS A 217
ASP A 170
 None
 0.87A 1i9gA-4nqfA:
undetectable		 1i9gA-4nqfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		3 GLU A  12
HIS A 481
ASP A 218
 None
 0.79A 1i9gA-4oetA:
undetectable		 1i9gA-4oetA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl7 ACTIN,THYMOSIN
BETA-4

(Homo sapiens;
Komagataella
phaffii) 		PF00022
(Actin)
PF01290
(Thymosin) 		3 GLU A 259
HIS A 263
ASP A 222
 None
 0.78A 1i9gA-4pl7A:
undetectable		 1i9gA-4pl7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 GLU A 443
HIS A 440
ASP A 465
 None
EDO  A 705 ( 4.0A)
None
 0.87A 1i9gA-4wd1A:
4.3		 1i9gA-4wd1A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE

(Burkholderia
pseudomallei) 		PF01063
(Aminotran_4) 		3 GLU A  39
HIS A  59
ASP A 219
 LLP  A 161 ( 3.9A)
LLP  A 161 ( 4.9A)
None
 0.76A 1i9gA-4whxA:
undetectable		 1i9gA-4whxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt8 RV2671

(Mycobacterium
tuberculosis) 		PF01872
(RibD_C) 		3 GLU A  76
HIS A 105
ASP A  33
 None
 0.83A 1i9gA-4xt8A:
undetectable		 1i9gA-4xt8A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 3 GLU A 150
HIS A 221
ASP A 145
 None
CA  A1101 (-3.5A)
None
 0.75A 1i9gA-5b7iA:
undetectable		 1i9gA-5b7iA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		3 GLU A 244
HIS A 188
ASP A 134
 None
None
T6T  A 501 (-1.9A)
 0.88A 1i9gA-5ci5A:
undetectable		 1i9gA-5ci5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLU A 314
HIS A 309
ASP A 285
 None
 0.86A 1i9gA-5cioA:
undetectable		 1i9gA-5cioA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		3 GLU A  81
HIS A  84
ASP A  50
 None
 0.63A 1i9gA-5e8kA:
undetectable		 1i9gA-5e8kA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 GLU A 212
HIS A 209
ASP A 100
 None
 0.78A 1i9gA-5eioA:
3.6		 1i9gA-5eioA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		3 GLU A 282
HIS A 285
ASP A 247
 None
 0.70A 1i9gA-5ev7A:
undetectable		 1i9gA-5ev7A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6q METALLOTHIOL
TRANSFERASE FOSB 2

(Bacillus
anthracis) 		PF00903
(Glyoxalase) 		3 GLU A 115
HIS A  66
ASP A 100
 ZN  A 201 ( 2.4A)
ZN  A 201 ( 3.2A)
None
 0.85A 1i9gA-5f6qA:
undetectable		 1i9gA-5f6qA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 GLU A 201
HIS A 183
ASP C 666
 None
 0.80A 1i9gA-5g5gA:
undetectable		 1i9gA-5g5gA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giv CARBOXYPEPTIDASE 1

(Deinococcus
radiodurans) 		PF02074
(Peptidase_M32) 		3 GLU A 303
HIS A 266
ASP A 351
 None
ZN  A 601 (-3.4A)
None
 0.59A 1i9gA-5givA:
undetectable		 1i9gA-5givA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guh PIWI

(Bombyx mori) 		PF02170
(PAZ)
PF02171
(Piwi) 		3 GLU A 578
HIS A 573
ASP A 605
 None
 0.53A 1i9gA-5guhA:
undetectable		 1i9gA-5guhA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jem INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		3 GLU A 310
HIS A 290
ASP A 314
 None
 0.68A 1i9gA-5jemA:
undetectable		 1i9gA-5jemA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLU A 417
HIS A 342
ASP A 326
 None
 0.87A 1i9gA-5jjqA:
4.3		 1i9gA-5jjqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpz SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 3 GLU A 518
HIS A 526
ASP A 497
 None
 0.71A 1i9gA-5jpzA:
undetectable		 1i9gA-5jpzA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgo FLAGELLAR BRAKE
PROTEIN YCGR

(Klebsiella
pneumoniae) 		no annotation 3 GLU D  28
HIS D  69
ASP D 140
 None
C2E  D 301 (-3.6A)
C2E  D 302 (-3.7A)
 0.73A 1i9gA-5kgoD:
undetectable		 1i9gA-5kgoD:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 3 GLU A1099
HIS A1096
ASP A1207
 None
 0.72A 1i9gA-5kk5A:
undetectable		 1i9gA-5kk5A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oo7 SLA2

(Chaetomium
thermophilum) 		no annotation 3 GLU A 135
HIS A 133
ASP A 153
 None
 0.82A 1i9gA-5oo7A:
undetectable		 1i9gA-5oo7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tge PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF17289
(Terminase_6C) 		3 GLU A 404
HIS A 427
ASP A 294
 None
 0.76A 1i9gA-5tgeA:
undetectable		 1i9gA-5tgeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vx6 UNCHARACTERIZED
PROTEIN YPFA

(Bacillus
subtilis) 		no annotation 3 GLU A 157
HIS A 160
ASP A 195
 None
 0.88A 1i9gA-5vx6A:
undetectable		 1i9gA-5vx6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		3 GLU A  93
HIS A  95
ASP A  66
 None
 0.63A 1i9gA-5y7oA:
undetectable		 1i9gA-5y7oA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 3 GLU A 449
HIS A 183
ASP A 391
 None
 0.79A 1i9gA-6bljA:
undetectable		 1i9gA-6bljA:
undetectable