SIMILAR PATTERNS OF AMINO ACIDS FOR 1I9G_A_SAMA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  49
GLY A  52
ALA A  87
LEU A  88
LEU A 124
 NAP  A 386 (-3.2A)
NAP  A 386 (-3.2A)
None
None
None
 1.25A 1i9gA-1civA:
7.1		 1i9gA-1civA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		5 ILE A 308
GLY A 169
ALA A 122
ASP A 217
LEU A 216
 None
 1.25A 1i9gA-1cn3A:
undetectable		 1i9gA-1cn3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqi PROTEIN
(SUCCINYL-COA
SYNTHETASE BETA
CHAIN)

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 ILE B 368
GLY B 331
GLY B 334
LEU B 327
VAL B 323
 None
 1.14A 1i9gA-1cqiB:
2.1		 1i9gA-1cqiB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE

(Hyphomicrobium
methylovorum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY A 154
GLY A 156
SER A 157
ALA A 161
LEU A 162
 None
 0.68A 1i9gA-1gdhA:
6.6		 1i9gA-1gdhA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		12 ILE A  83
GLY A 107
GLY A 109
SER A 110
ALA A 112
LEU A 113
GLN A 132
ARG A 133
ASP A 161
LEU A 162
MET A 179
VAL A 185
 SAM  A 301 (-4.0A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.7A)
None
 0.00A 1i9gA-1i9gA:
42.1		 1i9gA-1i9gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leh LEUCINE
DEHYDROGENASE

(Lysinibacillus
sphaericus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 180
GLY A 182
ALA A 187
LEU A 188
VAL A 242
 None
 1.23A 1i9gA-1lehA:
5.6		 1i9gA-1lehA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		5 ILE A1132
GLY A1099
GLY A1097
ALA A1119
ASP A1053
 None
 0.94A 1i9gA-1lurA:
undetectable		 1i9gA-1lurA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		5 ILE A 139
GLY A 131
GLY A 133
ALA A 138
LEU A 184
 None
NAI  A 301 ( 4.2A)
NAI  A 301 (-3.0A)
None
None
 1.29A 1i9gA-1o9bA:
8.4		 1i9gA-1o9bA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		5 ILE A  40
GLY A  44
GLY A 196
SER A 195
LEU A  46
 None
None
None
0G6  A   1 (-1.3A)
None
 1.14A 1i9gA-1orfA:
undetectable		 1i9gA-1orfA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 GLY A  35
ALA A  40
LEU A  41
LEU A  54
VAL A  72
 XMP  A 901 ( 4.3A)
None
None
None
None
 1.16A 1i9gA-1pl0A:
2.4		 1i9gA-1pl0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sva SIMIAN VIRUS 40

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		5 ILE 1 288
GLY 1 156
ALA 1 112
ASP 1 198
LEU 1 197
 None
 1.24A 1i9gA-1sva1:
undetectable		 1i9gA-1sva1:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE

(Clostridium
acetobutylicum) 		PF04029
(2-ph_phosp) 		5 ILE A 109
GLY A 121
ALA A 108
LEU A 124
VAL A 223
 None
 1.10A 1i9gA-1vr0A:
undetectable		 1i9gA-1vr0A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 ILE A 199
GLY A 193
GLY A 168
SER A 167
LEU A 189
 None
 1.25A 1i9gA-1wl1A:
undetectable		 1i9gA-1wl1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 ILE A  36
GLY A  28
GLY A  30
ALA A  35
VAL A 119
 None
 1.21A 1i9gA-1yj8A:
5.8		 1i9gA-1yj8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 GLY A 279
SER A 290
ALA A 293
LEU A 296
ASP A 226
 None
 1.20A 1i9gA-1yrwA:
4.1		 1i9gA-1yrwA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 GLY A 279
SER A 290
ALA A 293
LEU A 296
ASP A 226
 None
 1.21A 1i9gA-1z7eA:
6.4		 1i9gA-1z7eA:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		6 GLY A 111
GLY A 113
SER A 114
ARG A 137
ASP A 173
MET A 193
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
None
SAM  A 601 (-3.4A)
SAM  A 601 ( 4.2A)
 0.59A 1i9gA-2b25A:
25.8		 1i9gA-2b25A:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bej SEGREGATION PROTEIN

(Thermus
thermophilus) 		PF13614
(AAA_31) 		5 GLY A  19
ALA A 213
LEU A 212
LEU A  11
VAL A 138
 ADP  A 500 (-3.1A)
ADP  A 500 (-3.6A)
ADP  A 500 (-4.1A)
None
None
 1.02A 1i9gA-2bejA:
undetectable		 1i9gA-2bejA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 247
GLY A  76
ALA A 305
LEU A 304
VAL A 361
 None
 1.13A 1i9gA-2ebaA:
undetectable		 1i9gA-2ebaA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A  78
GLY A 247
SER A  72
ALA A  74
VAL A 361
 None
 1.23A 1i9gA-2ebaA:
undetectable		 1i9gA-2ebaA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		5 GLY A  46
GLY A  62
ALA A  37
GLN A  72
LEU A  70
 None
 1.24A 1i9gA-2ekmA:
undetectable		 1i9gA-2ekmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		6 GLY A  11
GLY A  14
SER A  15
ALA A  19
LEU A  20
ASP A  58
 None
DIO  A 407 (-3.5A)
DIO  A 407 ( 3.0A)
None
None
None
 1.08A 1i9gA-2hjsA:
4.3		 1i9gA-2hjsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l2g IGF2R DOMAIN 11

(Monodelphis
domestica) 		PF00878
(CIMR) 		5 ILE A1564
GLY A1567
GLY A1580
ALA A1590
LEU A1548
 None
 1.01A 1i9gA-2l2gA:
undetectable		 1i9gA-2l2gA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		5 GLY A 157
GLY A 154
SER A  67
ALA A  65
VAL A 187
 None
 1.27A 1i9gA-2osyA:
undetectable		 1i9gA-2osyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		5 ILE A 192
GLY A 183
GLY A 185
SER A 186
LEU A 212
 None
 1.22A 1i9gA-2ppvA:
4.7		 1i9gA-2ppvA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A 713
GLY A 660
GLY A 722
LEU A 658
VAL A 666
 None
 1.18A 1i9gA-2vdcA:
undetectable		 1i9gA-2vdcA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 332
GLY A 335
ALA A  88
LEU A  87
ASP A 531
 None
 1.20A 1i9gA-2x40A:
2.0		 1i9gA-2x40A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		5 ILE A  50
GLY A  87
SER A  88
ALA A  82
LEU A  85
 None
 1.21A 1i9gA-2yjpA:
undetectable		 1i9gA-2yjpA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		7 ILE A  75
GLY A  99
GLY A 101
SER A 102
ALA A 104
LEU A 105
ASP A 148
 SAM  A 601 (-4.1A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.1A)
 0.44A 1i9gA-2yvlA:
27.6		 1i9gA-2yvlA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 316
GLY A  84
GLY A 142
SER A 141
VAL A 398
 None
 0.85A 1i9gA-3bjsA:
undetectable		 1i9gA-3bjsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwq CAPSID PROTEIN VP1

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		5 ILE A 288
GLY A 156
ALA A 112
ASP A 198
LEU A 197
 None
 1.21A 1i9gA-3bwqA:
undetectable		 1i9gA-3bwqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		5 ILE A 173
GLY A 131
GLY A 224
LEU A 154
ASP A 108
 None
 1.11A 1i9gA-3djcA:
undetectable		 1i9gA-3djcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		5 GLY A  50
GLY A  52
ALA A  55
LEU A  56
ASP A 100
 SAM  A 220 (-3.5A)
SAM  A 220 (-3.2A)
SAM  A 220 ( 4.9A)
None
SAM  A 220 (-3.2A)
 0.49A 1i9gA-3dlcA:
15.5		 1i9gA-3dlcA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7n D-RIBOSE
HIGH-AFFINITY
TRANSPORT SYSTEM

(Salmonella
enterica) 		PF05025
(RbsD_FucU) 		5 ILE A  73
ALA A  70
LEU A  69
ARG A 121
VAL A  58
 None
 1.18A 1i9gA-3e7nA:
undetectable		 1i9gA-3e7nA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emv URIDINE
PHOSPHORYLASE,
PUTATIVE

(Plasmodium
vivax) 		PF01048
(PNP_UDP_1) 		5 ILE A  74
GLY A  66
GLY A  68
SER A  69
ALA A  73
 None
 0.90A 1i9gA-3emvA:
undetectable		 1i9gA-3emvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		5 GLY A  54
GLY A  56
ALA A  59
LEU A  60
ASP A  99
 None
 0.50A 1i9gA-3futA:
13.4		 1i9gA-3futA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfq FMN-DEPENDENT
NADPH-AZOREDUCTASE

(Bacillus
subtilis) 		PF03358
(FMN_red) 		5 GLY A  77
SER A  76
LEU A 115
ASP A  87
LEU A  86
 None
FMN  A 200 (-4.2A)
None
None
None
 1.09A 1i9gA-3gfqA:
undetectable		 1i9gA-3gfqA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 GLY A 126
SER A 127
ALA A 131
LEU A 133
VAL A 159
 None
 1.25A 1i9gA-3gzgA:
undetectable		 1i9gA-3gzgA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF01194
(RNA_pol_N) 		5 GLY J  32
GLY B1028
SER B1024
LEU B1026
LEU J  24
 None
 1.28A 1i9gA-3h0gJ:
undetectable		 1i9gA-3h0gJ:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ILE A 274
GLY A 279
ARG A 236
ASP A 288
VAL A 293
 None
 1.14A 1i9gA-3h2zA:
5.8		 1i9gA-3h2zA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 GLY A  81
GLY A 133
ALA A 154
ASP A  45
VAL A  37
 None
 1.25A 1i9gA-3ju1A:
undetectable		 1i9gA-3ju1A:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		7 GLY A 101
GLY A 103
SER A 104
ALA A 106
LEU A 107
ARG A 127
ASP A 153
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
None
SAH  A 301 (-3.1A)
 0.50A 1i9gA-3lgaA:
27.0		 1i9gA-3lgaA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		6 GLY A 101
GLY A 103
SER A 104
ALA A 106
LEU A 107
VAL A 176
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
None
 0.78A 1i9gA-3lgaA:
27.0		 1i9gA-3lgaA:
34.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lic SENSOR PROTEIN

(Shewanella
oneidensis) 		PF02743
(dCache_1) 		5 ILE A 140
SER A 109
ARG A 130
ASP A 204
LEU A 179
 None
 1.06A 1i9gA-3licA:
undetectable		 1i9gA-3licA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		5 ILE A  21
GLY A  12
ALA A  20
ASP A  59
LEU A  58
 None
 1.30A 1i9gA-3m1aA:
6.8		 1i9gA-3m1aA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 5 GLY A 164
GLY A 197
ALA A 238
ARG A 162
ASP A 136
 None
None
None
SO4  A   1 (-3.9A)
None
 1.17A 1i9gA-3n6zA:
undetectable		 1i9gA-3n6zA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 GLY A 109
GLY A 157
ALA A 184
LEU A 183
GLN A 154
 None
 1.10A 1i9gA-3nvsA:
undetectable		 1i9gA-3nvsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 ILE A 557
GLY A 408
ALA A 565
LEU A 410
VAL A 402
 None
 1.19A 1i9gA-3opyA:
undetectable		 1i9gA-3opyA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p13 D-RIBOSE PYRANASE

(Staphylococcus
aureus) 		PF05025
(RbsD_FucU) 		5 ILE A  75
ALA A  72
LEU A  71
ARG A 118
VAL A  60
 None
 1.16A 1i9gA-3p13A:
undetectable		 1i9gA-3p13A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbi INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		5 ILE A 167
GLY A 172
ALA A 177
GLN A 200
ASP A  37
 None
 1.28A 1i9gA-3pbiA:
undetectable		 1i9gA-3pbiA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfd ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 240
SER A 191
ALA A 179
ASP A 249
LEU A 248
 None
IOD  A 410 ( 4.9A)
None
None
None
 1.06A 1i9gA-3pfdA:
undetectable		 1i9gA-3pfdA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE

(Aliivibrio
fischeri) 		PF02719
(Polysacc_synt_2) 		5 GLY A  39
GLY A  42
SER A  43
ALA A  47
ASP A  94
 NAD  A 501 ( 3.7A)
NAD  A 501 (-3.1A)
NAD  A 501 (-3.6A)
None
NAD  A 501 (-3.3A)
 0.85A 1i9gA-3pvzA:
7.2		 1i9gA-3pvzA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4w MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 290
GLY A  38
GLY A  96
SER A  95
VAL A 369
 None
 0.84A 1i9gA-3t4wA:
undetectable		 1i9gA-3t4wA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		5 ILE A 204
GLY A 184
ALA A 207
LEU A 173
VAL A 118
 None
 1.20A 1i9gA-3t8lA:
undetectable		 1i9gA-3t8lA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfd SPASTIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 GLY A 547
SER A 548
ALA A 552
LEU A 553
LEU A 516
 None
 0.97A 1i9gA-3vfdA:
undetectable		 1i9gA-3vfdA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 ILE A 414
GLY A 381
GLY A   8
ALA A 412
ARG A 362
 None
 1.28A 1i9gA-3zh4A:
undetectable		 1i9gA-3zh4A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		5 GLY A 342
GLY A 192
SER A 193
ASP A 348
VAL A 274
 None
 1.23A 1i9gA-3zrpA:
undetectable		 1i9gA-3zrpA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d48 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Erwinia
amylovora) 		PF00483
(NTP_transferase) 		5 GLY A 280
GLY A 287
SER A 288
ALA A 292
LEU A 294
 None
 1.28A 1i9gA-4d48A:
undetectable		 1i9gA-4d48A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE

(Pantoea
ananatis) 		PF01593
(Amino_oxidase) 		5 GLY A   8
GLY A  10
ALA A  15
LEU A  16
VAL A 244
 None
 1.11A 1i9gA-4dgkA:
undetectable		 1i9gA-4dgkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 GLY A  48
ALA A 205
LEU A 204
ASP A  10
LEU A  13
 None
 1.22A 1i9gA-4di1A:
undetectable		 1i9gA-4di1A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqx PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 GLY A  34
GLY A  36
ALA A  42
ASP A  81
VAL A 131
 None
 1.01A 1i9gA-4dqxA:
7.1		 1i9gA-4dqxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS

(Burkholderia
ambifaria) 		PF00571
(CBS) 		5 ILE A   8
GLY A 118
GLY A  16
SER A  15
LEU A  44
 None
 1.24A 1i9gA-4fryA:
undetectable		 1i9gA-4fryA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		5 ILE A 150
GLY A 135
GLY A 161
ALA A 154
LEU A  96
 None
 1.22A 1i9gA-4hjwA:
undetectable		 1i9gA-4hjwA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		5 GLY A 197
GLY A 275
LEU A  27
MET A 217
VAL A 237
 None
 1.05A 1i9gA-4hpvA:
undetectable		 1i9gA-4hpvA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		5 ILE A 520
GLY A  76
GLY A  47
ALA A 523
ASP A  72
 FAD  A 601 (-4.2A)
FAD  A 601 (-3.1A)
FAD  A 601 (-3.6A)
FAD  A 601 (-3.1A)
None
 1.09A 1i9gA-4iv9A:
4.0		 1i9gA-4iv9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 290
GLY A  39
GLY A  97
SER A  96
VAL A 346
 None
 1.07A 1i9gA-4j3zA:
undetectable		 1i9gA-4j3zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbx UNCHARACTERIZED
PROTEIN YHFX

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		5 GLY A 261
SER A 238
ALA A 236
GLN A  37
ASP A  34
 None
None
LLP  A  61 ( 4.8A)
None
None
 1.28A 1i9gA-4kbxA:
undetectable		 1i9gA-4kbxA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdr 3-DEMETHYLUBIQUINONE
-9
3-METHYLTRANSFERASE

(Escherichia
coli) 		PF13489
(Methyltransf_23) 		5 GLY A  64
GLY A  66
LEU A  70
MET A 131
VAL A 141
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.2A)
None
None
None
 0.52A 1i9gA-4kdrA:
16.1		 1i9gA-4kdrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lji CYTOCHROME
C-550-LIKE PROTEIN

(Thermosynechococcus
elongatus) 		PF14495
(Cytochrom_C550) 		5 ILE A 121
GLY A  53
GLY A 132
SER A  65
ALA A 125
 None
 1.11A 1i9gA-4ljiA:
undetectable		 1i9gA-4ljiA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj0 VP1 CAPSID PROTEIN

(Human
polyomavirus 1) 		PF00718
(Polyoma_coat) 		5 ILE A 288
GLY A 156
ALA A 112
ASP A 198
LEU A 197
 None
 1.21A 1i9gA-4mj0A:
undetectable		 1i9gA-4mj0A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 284
GLY A 421
GLY A 171
ALA A 238
VAL A 141
 None
 1.25A 1i9gA-4mksA:
undetectable		 1i9gA-4mksA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 ILE A 156
SER A 179
ALA A 183
LEU A 184
ARG A 171
 None
 1.19A 1i9gA-4ox2A:
undetectable		 1i9gA-4ox2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		5 ILE A 281
GLY A 256
ALA A 248
LEU A 247
VAL A 200
 None
None
None
None
KCX  A 108 ( 4.4A)
 1.03A 1i9gA-4s38A:
undetectable		 1i9gA-4s38A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 ILE A 429
GLY A  94
ALA A 428
ARG A 101
VAL A 574
 None
 1.26A 1i9gA-4xnuA:
undetectable		 1i9gA-4xnuA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 GLY A 157
ALA A 165
LEU A 164
GLN A 154
ASP A 102
 None
 1.30A 1i9gA-4yweA:
4.0		 1i9gA-4yweA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyb HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 GLY A 247
SER A 212
ALA A 210
LEU A 151
VAL A 125
 None
 1.22A 1i9gA-4yybA:
undetectable		 1i9gA-4yybA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		5 GLY A  12
GLY A  17
ALA A 168
LEU A 223
VAL A 187
 FAD  A 601 (-3.2A)
None
None
FAD  A 601 (-3.7A)
FAD  A 601 (-3.8A)
 1.29A 1i9gA-4z43A:
undetectable		 1i9gA-4z43A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos) 		5 ILE A 216
GLY A 167
ALA A 206
ASP A 139
LEU A 174
 None
 1.27A 1i9gA-5b8iA:
undetectable		 1i9gA-5b8iA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		5 ILE A 199
GLY A 191
GLY A 193
SER A 194
ALA A 198
 None
NAD  A 401 (-3.0A)
NAD  A 401 (-3.4A)
NAD  A 401 (-4.5A)
None
 0.97A 1i9gA-5ceeA:
undetectable		 1i9gA-5ceeA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 GLY A  17
GLY A  19
ALA A  24
LEU A  25
VAL A 132
 None
 0.83A 1i9gA-5cqfA:
4.0		 1i9gA-5cqfA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 5 GLY B 544
GLY B 546
SER B 547
ASP B 539
LEU B 540
 None
 1.02A 1i9gA-5cwwB:
undetectable		 1i9gA-5cwwB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 ALA A  67
LEU A  70
ASP A 109
LEU A  83
VAL A 141
 None
 1.10A 1i9gA-5d6nA:
2.7		 1i9gA-5d6nA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLY A  11
GLY A  13
ALA A  18
GLN A  35
LEU A 130
 FAD  A 401 (-3.0A)
FAD  A 401 (-3.4A)
None
FAD  A 401 (-3.3A)
FAD  A 401 (-4.6A)
 1.03A 1i9gA-5eowA:
3.3		 1i9gA-5eowA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 5 GLY I 573
SER I 574
GLN I 650
ARG I 654
ASP I 646
 None
 0.95A 1i9gA-5furI:
undetectable		 1i9gA-5furI:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		5 ILE A 591
GLY A 631
SER A 550
ALA A 554
VAL A 651
 None
 1.23A 1i9gA-5gw7A:
undetectable		 1i9gA-5gw7A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 5 ILE A 325
GLY A 336
ALA A 338
GLN A 257
LEU A 267
 None
 1.29A 1i9gA-5h4eA:
undetectable		 1i9gA-5h4eA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqn ALIPHATIC AMIDASE

(Nesterenkonia
sp. AN1) 		PF00795
(CN_hydrolase) 		5 GLY A 216
GLY A 219
ALA A 185
LEU A 236
VAL A 234
 None
 1.26A 1i9gA-5jqnA:
undetectable		 1i9gA-5jqnA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
DELTA-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01217
(Clat_adaptor_s) 		5 GLY B  12
ALA B  34
LEU B  33
ASP B  62
LEU B  61
 None
 1.13A 1i9gA-5mu7B:
undetectable		 1i9gA-5mu7B:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN
SMALL ENVELOPE
PROTEIN M

(Tick-borne
encephalitis
virus;
Tick-borne
encephalitis
virus) 		no annotation
no annotation 		5 GLY A 468
ALA A 483
LEU A 482
LEU D  52
MET A 476
 None
 1.16A 1i9gA-5o6vA:
undetectable		 1i9gA-5o6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 ILE A 353
GLY A 297
SER A 446
ALA A 448
VAL A 306
 None
 1.06A 1i9gA-5od2A:
4.4		 1i9gA-5od2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ode GLL2934 PROTEIN

(Gloeobacter
violaceus) 		no annotation 5 GLY A  24
GLY A  22
ALA A 123
LEU A 284
LEU A  70
 FAD  A 400 (-2.9A)
FAD  A 400 (-3.1A)
None
None
None
 1.18A 1i9gA-5odeA:
3.6		 1i9gA-5odeA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		5 ILE A 213
GLY A 363
GLY A 255
ALA A 259
LEU A 343
 None
 1.11A 1i9gA-5uc7A:
undetectable		 1i9gA-5uc7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 5 GLY A 116
GLY A 118
SER A 119
ALA A 123
LEU A 124
 FAD  A 601 (-3.1A)
FAD  A 601 (-2.9A)
FAD  A 601 (-3.8A)
None
None
 0.89A 1i9gA-5w1jA:
3.0		 1i9gA-5w1jA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 5 GLY A 108
ALA A 113
LEU A 115
ASP A 146
LEU A 149
 None
 1.09A 1i9gA-5whsA:
undetectable		 1i9gA-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		5 ILE A 142
GLY A 160
GLY A 226
SER A 227
LEU A 156
 None
 0.74A 1i9gA-5x62A:
9.6		 1i9gA-5x62A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y50 PROTEIN
DETOXIFICATION 14

(Arabidopsis
thaliana) 		no annotation 5 GLY A 202
GLY A 204
SER A 205
ALA A 208
LEU A 197
 None
 1.09A 1i9gA-5y50A:
undetectable		 1i9gA-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Sulfolobus
acidocaldarius) 		no annotation 5 GLY A  24
GLY A  26
SER A  27
ALA A  31
VAL A  89
 None
 1.21A 1i9gA-5yeqA:
4.9		 1i9gA-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cim V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 5 ILE B 256
GLY B 221
SER B 259
LEU B 219
LEU B 200
 None
 0.93A 1i9gA-6cimB:
undetectable		 1i9gA-6cimB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 GLY C 991
SER C 992
ALA C 996
LEU C 997
LEU C1024
 None
 0.94A 1i9gA-6en4C:
undetectable		 1i9gA-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esb CAPSID PROTEIN VP1

(Human
polyomavirus 1) 		no annotation 5 ILE 1 288
GLY 1 156
ALA 1 112
ASP 1 198
LEU 1 197
 None
 1.17A 1i9gA-6esb1:
undetectable		 1i9gA-6esb1:
undetectable