SIMILAR PATTERNS OF AMINO ACIDS FOR 1I9G_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  49
GLY A  52
ALA A  87
LEU A  88
LEU A 124
 NAP  A 386 (-3.2A)
NAP  A 386 (-3.2A)
None
None
None
 1.25A 1i9gA-1civA:
7.1		 1i9gA-1civA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		5 ILE A 308
GLY A 169
ALA A 122
ASP A 217
LEU A 216
 None
 1.25A 1i9gA-1cn3A:
undetectable		 1i9gA-1cn3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqi PROTEIN
(SUCCINYL-COA
SYNTHETASE BETA
CHAIN)

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 ILE B 368
GLY B 331
GLY B 334
LEU B 327
VAL B 323
 None
 1.14A 1i9gA-1cqiB:
2.1		 1i9gA-1cqiB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE

(Hyphomicrobium
methylovorum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY A 154
GLY A 156
SER A 157
ALA A 161
LEU A 162
 None
 0.68A 1i9gA-1gdhA:
6.6		 1i9gA-1gdhA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		12 ILE A  83
GLY A 107
GLY A 109
SER A 110
ALA A 112
LEU A 113
GLN A 132
ARG A 133
ASP A 161
LEU A 162
MET A 179
VAL A 185
 SAM  A 301 (-4.0A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.7A)
None
 0.00A 1i9gA-1i9gA:
42.1		 1i9gA-1i9gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leh LEUCINE
DEHYDROGENASE

(Lysinibacillus
sphaericus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 180
GLY A 182
ALA A 187
LEU A 188
VAL A 242
 None
 1.23A 1i9gA-1lehA:
5.6		 1i9gA-1lehA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		5 ILE A1132
GLY A1099
GLY A1097
ALA A1119
ASP A1053
 None
 0.94A 1i9gA-1lurA:
undetectable		 1i9gA-1lurA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		5 ILE A 139
GLY A 131
GLY A 133
ALA A 138
LEU A 184
 None
NAI  A 301 ( 4.2A)
NAI  A 301 (-3.0A)
None
None
 1.29A 1i9gA-1o9bA:
8.4		 1i9gA-1o9bA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		5 ILE A  40
GLY A  44
GLY A 196
SER A 195
LEU A  46
 None
None
None
0G6  A   1 (-1.3A)
None
 1.14A 1i9gA-1orfA:
undetectable		 1i9gA-1orfA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 GLY A  35
ALA A  40
LEU A  41
LEU A  54
VAL A  72
 XMP  A 901 ( 4.3A)
None
None
None
None
 1.16A 1i9gA-1pl0A:
2.4		 1i9gA-1pl0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sva SIMIAN VIRUS 40

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		5 ILE 1 288
GLY 1 156
ALA 1 112
ASP 1 198
LEU 1 197
 None
 1.24A 1i9gA-1sva1:
undetectable		 1i9gA-1sva1:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE

(Clostridium
acetobutylicum) 		PF04029
(2-ph_phosp) 		5 ILE A 109
GLY A 121
ALA A 108
LEU A 124
VAL A 223
 None
 1.10A 1i9gA-1vr0A:
undetectable		 1i9gA-1vr0A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 ILE A 199
GLY A 193
GLY A 168
SER A 167
LEU A 189
 None
 1.25A 1i9gA-1wl1A:
undetectable		 1i9gA-1wl1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 ILE A  36
GLY A  28
GLY A  30
ALA A  35
VAL A 119
 None
 1.21A 1i9gA-1yj8A:
5.8		 1i9gA-1yj8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 GLY A 279
SER A 290
ALA A 293
LEU A 296
ASP A 226
 None
 1.20A 1i9gA-1yrwA:
4.1		 1i9gA-1yrwA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 GLY A 279
SER A 290
ALA A 293
LEU A 296
ASP A 226
 None
 1.21A 1i9gA-1z7eA:
6.4		 1i9gA-1z7eA:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		6 GLY A 111
GLY A 113
SER A 114
ARG A 137
ASP A 173
MET A 193
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
None
SAM  A 601 (-3.4A)
SAM  A 601 ( 4.2A)
 0.59A 1i9gA-2b25A:
25.8		 1i9gA-2b25A:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bej SEGREGATION PROTEIN

(Thermus
thermophilus) 		PF13614
(AAA_31) 		5 GLY A  19
ALA A 213
LEU A 212
LEU A  11
VAL A 138
 ADP  A 500 (-3.1A)
ADP  A 500 (-3.6A)
ADP  A 500 (-4.1A)
None
None
 1.02A 1i9gA-2bejA:
undetectable		 1i9gA-2bejA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 247
GLY A  76
ALA A 305
LEU A 304
VAL A 361
 None
 1.13A 1i9gA-2ebaA:
undetectable		 1i9gA-2ebaA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A  78
GLY A 247
SER A  72
ALA A  74
VAL A 361
 None
 1.23A 1i9gA-2ebaA:
undetectable		 1i9gA-2ebaA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		5 GLY A  46
GLY A  62
ALA A  37
GLN A  72
LEU A  70
 None
 1.24A 1i9gA-2ekmA:
undetectable		 1i9gA-2ekmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		6 GLY A  11
GLY A  14
SER A  15
ALA A  19
LEU A  20
ASP A  58
 None
DIO  A 407 (-3.5A)
DIO  A 407 ( 3.0A)
None
None
None
 1.08A 1i9gA-2hjsA:
4.3		 1i9gA-2hjsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l2g IGF2R DOMAIN 11

(Monodelphis
domestica) 		PF00878
(CIMR) 		5 ILE A1564
GLY A1567
GLY A1580
ALA A1590
LEU A1548
 None
 1.01A 1i9gA-2l2gA:
undetectable		 1i9gA-2l2gA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		5 GLY A 157
GLY A 154
SER A  67
ALA A  65
VAL A 187
 None
 1.27A 1i9gA-2osyA:
undetectable		 1i9gA-2osyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		5 ILE A 192
GLY A 183
GLY A 185
SER A 186
LEU A 212
 None
 1.22A 1i9gA-2ppvA:
4.7		 1i9gA-2ppvA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A 713
GLY A 660
GLY A 722
LEU A 658
VAL A 666
 None
 1.18A 1i9gA-2vdcA:
undetectable		 1i9gA-2vdcA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 332
GLY A 335
ALA A  88
LEU A  87
ASP A 531
 None
 1.20A 1i9gA-2x40A:
2.0		 1i9gA-2x40A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		5 ILE A  50
GLY A  87
SER A  88
ALA A  82
LEU A  85
 None
 1.21A 1i9gA-2yjpA:
undetectable		 1i9gA-2yjpA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		7 ILE A  75
GLY A  99
GLY A 101
SER A 102
ALA A 104
LEU A 105
ASP A 148
 SAM  A 601 (-4.1A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.1A)
 0.44A 1i9gA-2yvlA:
27.6		 1i9gA-2yvlA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 316
GLY A  84
GLY A 142
SER A 141
VAL A 398
 None
 0.85A 1i9gA-3bjsA:
undetectable		 1i9gA-3bjsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwq CAPSID PROTEIN VP1

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		5 ILE A 288
GLY A 156
ALA A 112
ASP A 198
LEU A 197
 None
 1.21A 1i9gA-3bwqA:
undetectable		 1i9gA-3bwqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		5 ILE A 173
GLY A 131
GLY A 224
LEU A 154
ASP A 108
 None
 1.11A 1i9gA-3djcA:
undetectable		 1i9gA-3djcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		5 GLY A  50
GLY A  52
ALA A  55
LEU A  56
ASP A 100
 SAM  A 220 (-3.5A)
SAM  A 220 (-3.2A)
SAM  A 220 ( 4.9A)
None
SAM  A 220 (-3.2A)
 0.49A 1i9gA-3dlcA:
15.5		 1i9gA-3dlcA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7n D-RIBOSE
HIGH-AFFINITY
TRANSPORT SYSTEM

(Salmonella
enterica) 		PF05025
(RbsD_FucU) 		5 ILE A  73
ALA A  70
LEU A  69
ARG A 121
VAL A  58
 None
 1.18A 1i9gA-3e7nA:
undetectable		 1i9gA-3e7nA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emv URIDINE
PHOSPHORYLASE,
PUTATIVE

(Plasmodium
vivax) 		PF01048
(PNP_UDP_1) 		5 ILE A  74
GLY A  66
GLY A  68
SER A  69
ALA A  73
 None
 0.90A 1i9gA-3emvA:
undetectable		 1i9gA-3emvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		5 GLY A  54
GLY A  56
ALA A  59
LEU A  60
ASP A  99
 None
 0.50A 1i9gA-3futA:
13.4		 1i9gA-3futA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfq FMN-DEPENDENT
NADPH-AZOREDUCTASE

(Bacillus
subtilis) 		PF03358
(FMN_red) 		5 GLY A  77
SER A  76
LEU A 115
ASP A  87
LEU A  86
 None
FMN  A 200 (-4.2A)
None
None
None
 1.09A 1i9gA-3gfqA:
undetectable		 1i9gA-3gfqA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 GLY A 126
SER A 127
ALA A 131
LEU A 133
VAL A 159
 None
 1.25A 1i9gA-3gzgA:
undetectable		 1i9gA-3gzgA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF01194
(RNA_pol_N) 		5 GLY J  32
GLY B1028
SER B1024
LEU B1026
LEU J  24
 None
 1.28A 1i9gA-3h0gJ:
undetectable		 1i9gA-3h0gJ:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ILE A 274
GLY A 279
ARG A 236
ASP A 288
VAL A 293
 None
 1.14A 1i9gA-3h2zA:
5.8		 1i9gA-3h2zA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 GLY A  81
GLY A 133
ALA A 154
ASP A  45
VAL A  37
 None
 1.25A 1i9gA-3ju1A:
undetectable		 1i9gA-3ju1A:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		7 GLY A 101
GLY A 103
SER A 104
ALA A 106
LEU A 107
ARG A 127
ASP A 153
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
None
SAH  A 301 (-3.1A)
 0.50A 1i9gA-3lgaA:
27.0		 1i9gA-3lgaA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		6 GLY A 101
GLY A 103
SER A 104
ALA A 106
LEU A 107
VAL A 176
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
None
 0.78A 1i9gA-3lgaA:
27.0		 1i9gA-3lgaA:
34.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lic SENSOR PROTEIN

(Shewanella
oneidensis) 		PF02743
(dCache_1) 		5 ILE A 140
SER A 109
ARG A 130
ASP A 204
LEU A 179
 None
 1.06A 1i9gA-3licA:
undetectable		 1i9gA-3licA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		5 ILE A  21
GLY A  12
ALA A  20
ASP A  59
LEU A  58
 None
 1.30A 1i9gA-3m1aA:
6.8		 1i9gA-3m1aA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 5 GLY A 164
GLY A 197
ALA A 238
ARG A 162
ASP A 136
 None
None
None
SO4  A   1 (-3.9A)
None
 1.17A 1i9gA-3n6zA:
undetectable		 1i9gA-3n6zA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 GLY A 109
GLY A 157
ALA A 184
LEU A 183
GLN A 154
 None
 1.10A 1i9gA-3nvsA:
undetectable		 1i9gA-3nvsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 ILE A 557
GLY A 408
ALA A 565
LEU A 410
VAL A 402
 None
 1.19A 1i9gA-3opyA:
undetectable		 1i9gA-3opyA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p13 D-RIBOSE PYRANASE

(Staphylococcus
aureus) 		PF05025
(RbsD_FucU) 		5 ILE A  75
ALA A  72
LEU A  71
ARG A 118
VAL A  60
 None
 1.16A 1i9gA-3p13A:
undetectable		 1i9gA-3p13A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbi INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		5 ILE A 167
GLY A 172
ALA A 177
GLN A 200
ASP A  37
 None
 1.28A 1i9gA-3pbiA:
undetectable		 1i9gA-3pbiA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfd ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 240
SER A 191
ALA A 179
ASP A 249
LEU A 248
 None
IOD  A 410 ( 4.9A)
None
None
None
 1.06A 1i9gA-3pfdA:
undetectable		 1i9gA-3pfdA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE

(Aliivibrio
fischeri) 		PF02719
(Polysacc_synt_2) 		5 GLY A  39
GLY A  42
SER A  43
ALA A  47
ASP A  94
 NAD  A 501 ( 3.7A)
NAD  A 501 (-3.1A)
NAD  A 501 (-3.6A)
None
NAD  A 501 (-3.3A)
 0.85A 1i9gA-3pvzA:
7.2		 1i9gA-3pvzA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4w MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 290
GLY A  38
GLY A  96
SER A  95
VAL A 369
 None
 0.84A 1i9gA-3t4wA:
undetectable		 1i9gA-3t4wA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		5 ILE A 204
GLY A 184
ALA A 207
LEU A 173
VAL A 118
 None
 1.20A 1i9gA-3t8lA:
undetectable		 1i9gA-3t8lA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfd SPASTIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 GLY A 547
SER A 548
ALA A 552
LEU A 553
LEU A 516
 None
 0.97A 1i9gA-3vfdA:
undetectable		 1i9gA-3vfdA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 ILE A 414
GLY A 381
GLY A   8
ALA A 412
ARG A 362
 None
 1.28A 1i9gA-3zh4A:
undetectable		 1i9gA-3zh4A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		5 GLY A 342
GLY A 192
SER A 193
ASP A 348
VAL A 274
 None
 1.23A 1i9gA-3zrpA:
undetectable		 1i9gA-3zrpA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d48 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Erwinia
amylovora) 		PF00483
(NTP_transferase) 		5 GLY A 280
GLY A 287
SER A 288
ALA A 292
LEU A 294
 None
 1.28A 1i9gA-4d48A:
undetectable		 1i9gA-4d48A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE

(Pantoea
ananatis) 		PF01593
(Amino_oxidase) 		5 GLY A   8
GLY A  10
ALA A  15
LEU A  16
VAL A 244
 None
 1.11A 1i9gA-4dgkA:
undetectable		 1i9gA-4dgkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 GLY A  48
ALA A 205
LEU A 204
ASP A  10
LEU A  13
 None
 1.22A 1i9gA-4di1A:
undetectable		 1i9gA-4di1A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqx PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 GLY A  34
GLY A  36
ALA A  42
ASP A  81
VAL A 131
 None
 1.01A 1i9gA-4dqxA:
7.1		 1i9gA-4dqxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS

(Burkholderia
ambifaria) 		PF00571
(CBS) 		5 ILE A   8
GLY A 118
GLY A  16
SER A  15
LEU A  44
 None
 1.24A 1i9gA-4fryA:
undetectable		 1i9gA-4fryA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		5 ILE A 150
GLY A 135
GLY A 161
ALA A 154
LEU A  96
 None
 1.22A 1i9gA-4hjwA:
undetectable		 1i9gA-4hjwA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		5 GLY A 197
GLY A 275
LEU A  27
MET A 217
VAL A 237
 None
 1.05A 1i9gA-4hpvA:
undetectable		 1i9gA-4hpvA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		5 ILE A 520
GLY A  76
GLY A  47
ALA A 523
ASP A  72
 FAD  A 601 (-4.2A)
FAD  A 601 (-3.1A)
FAD  A 601 (-3.6A)
FAD  A 601 (-3.1A)
None
 1.09A 1i9gA-4iv9A:
4.0		 1i9gA-4iv9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 290
GLY A  39
GLY A  97
SER A  96
VAL A 346
 None
 1.07A 1i9gA-4j3zA:
undetectable		 1i9gA-4j3zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbx UNCHARACTERIZED
PROTEIN YHFX

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		5 GLY A 261
SER A 238
ALA A 236
GLN A  37
ASP A  34
 None
None
LLP  A  61 ( 4.8A)
None
None
 1.28A 1i9gA-4kbxA:
undetectable		 1i9gA-4kbxA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdr 3-DEMETHYLUBIQUINONE
-9
3-METHYLTRANSFERASE

(Escherichia
coli) 		PF13489
(Methyltransf_23) 		5 GLY A  64
GLY A  66
LEU A  70
MET A 131
VAL A 141
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.2A)
None
None
None
 0.52A 1i9gA-4kdrA:
16.1		 1i9gA-4kdrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lji CYTOCHROME
C-550-LIKE PROTEIN

(Thermosynechococcus
elongatus) 		PF14495
(Cytochrom_C550) 		5 ILE A 121
GLY A  53
GLY A 132
SER A  65
ALA A 125
 None
 1.11A 1i9gA-4ljiA:
undetectable		 1i9gA-4ljiA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj0 VP1 CAPSID PROTEIN

(Human
polyomavirus 1) 		PF00718
(Polyoma_coat) 		5 ILE A 288
GLY A 156
ALA A 112
ASP A 198
LEU A 197
 None
 1.21A 1i9gA-4mj0A:
undetectable		 1i9gA-4mj0A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 284
GLY A 421
GLY A 171
ALA A 238
VAL A 141
 None
 1.25A 1i9gA-4mksA:
undetectable		 1i9gA-4mksA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 ILE A 156
SER A 179
ALA A 183
LEU A 184
ARG A 171
 None
 1.19A 1i9gA-4ox2A:
undetectable		 1i9gA-4ox2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		5 ILE A 281
GLY A 256
ALA A 248
LEU A 247
VAL A 200
 None
None
None
None
KCX  A 108 ( 4.4A)
 1.03A 1i9gA-4s38A:
undetectable		 1i9gA-4s38A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 ILE A 429
GLY A  94
ALA A 428
ARG A 101
VAL A 574
 None
 1.26A 1i9gA-4xnuA:
undetectable		 1i9gA-4xnuA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 GLY A 157
ALA A 165
LEU A 164
GLN A 154
ASP A 102
 None
 1.30A 1i9gA-4yweA:
4.0		 1i9gA-4yweA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyb HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 GLY A 247
SER A 212
ALA A 210
LEU A 151
VAL A 125
 None
 1.22A 1i9gA-4yybA:
undetectable		 1i9gA-4yybA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		5 GLY A  12
GLY A  17
ALA A 168
LEU A 223
VAL A 187
 FAD  A 601 (-3.2A)
None
None
FAD  A 601 (-3.7A)
FAD  A 601 (-3.8A)
 1.29A 1i9gA-4z43A:
undetectable		 1i9gA-4z43A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos) 		5 ILE A 216
GLY A 167
ALA A 206
ASP A 139
LEU A 174
 None
 1.27A 1i9gA-5b8iA:
undetectable		 1i9gA-5b8iA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		5 ILE A 199
GLY A 191
GLY A 193
SER A 194
ALA A 198
 None
NAD  A 401 (-3.0A)
NAD  A 401 (-3.4A)
NAD  A 401 (-4.5A)
None
 0.97A 1i9gA-5ceeA:
undetectable		 1i9gA-5ceeA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 GLY A  17
GLY A  19
ALA A  24
LEU A  25
VAL A 132
 None
 0.83A 1i9gA-5cqfA:
4.0		 1i9gA-5cqfA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 5 GLY B 544
GLY B 546
SER B 547
ASP B 539
LEU B 540
 None
 1.02A 1i9gA-5cwwB:
undetectable		 1i9gA-5cwwB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 ALA A  67
LEU A  70
ASP A 109
LEU A  83
VAL A 141
 None
 1.10A 1i9gA-5d6nA:
2.7		 1i9gA-5d6nA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLY A  11
GLY A  13
ALA A  18
GLN A  35
LEU A 130
 FAD  A 401 (-3.0A)
FAD  A 401 (-3.4A)
None
FAD  A 401 (-3.3A)
FAD  A 401 (-4.6A)
 1.03A 1i9gA-5eowA:
3.3		 1i9gA-5eowA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 5 GLY I 573
SER I 574
GLN I 650
ARG I 654
ASP I 646
 None
 0.95A 1i9gA-5furI:
undetectable		 1i9gA-5furI:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		5 ILE A 591
GLY A 631
SER A 550
ALA A 554
VAL A 651
 None
 1.23A 1i9gA-5gw7A:
undetectable		 1i9gA-5gw7A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 5 ILE A 325
GLY A 336
ALA A 338
GLN A 257
LEU A 267
 None
 1.29A 1i9gA-5h4eA:
undetectable		 1i9gA-5h4eA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqn ALIPHATIC AMIDASE

(Nesterenkonia
sp. AN1) 		PF00795
(CN_hydrolase) 		5 GLY A 216
GLY A 219
ALA A 185
LEU A 236
VAL A 234
 None
 1.26A 1i9gA-5jqnA:
undetectable		 1i9gA-5jqnA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
DELTA-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01217
(Clat_adaptor_s) 		5 GLY B  12
ALA B  34
LEU B  33
ASP B  62
LEU B  61
 None
 1.13A 1i9gA-5mu7B:
undetectable		 1i9gA-5mu7B:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN
SMALL ENVELOPE
PROTEIN M

(Tick-borne
encephalitis
virus;
Tick-borne
encephalitis
virus) 		no annotation
no annotation 		5 GLY A 468
ALA A 483
LEU A 482
LEU D  52
MET A 476
 None
 1.16A 1i9gA-5o6vA:
undetectable		 1i9gA-5o6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 ILE A 353
GLY A 297
SER A 446
ALA A 448
VAL A 306
 None
 1.06A 1i9gA-5od2A:
4.4		 1i9gA-5od2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ode GLL2934 PROTEIN

(Gloeobacter
violaceus) 		no annotation 5 GLY A  24
GLY A  22
ALA A 123
LEU A 284
LEU A  70
 FAD  A 400 (-2.9A)
FAD  A 400 (-3.1A)
None
None
None
 1.18A 1i9gA-5odeA:
3.6		 1i9gA-5odeA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		5 ILE A 213
GLY A 363
GLY A 255
ALA A 259
LEU A 343
 None
 1.11A 1i9gA-5uc7A:
undetectable		 1i9gA-5uc7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 5 GLY A 116
GLY A 118
SER A 119
ALA A 123
LEU A 124
 FAD  A 601 (-3.1A)
FAD  A 601 (-2.9A)
FAD  A 601 (-3.8A)
None
None
 0.89A 1i9gA-5w1jA:
3.0		 1i9gA-5w1jA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 5 GLY A 108
ALA A 113
LEU A 115
ASP A 146
LEU A 149
 None
 1.09A 1i9gA-5whsA:
undetectable		 1i9gA-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		5 ILE A 142
GLY A 160
GLY A 226
SER A 227
LEU A 156
 None
 0.74A 1i9gA-5x62A:
9.6		 1i9gA-5x62A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y50 PROTEIN
DETOXIFICATION 14

(Arabidopsis
thaliana) 		no annotation 5 GLY A 202
GLY A 204
SER A 205
ALA A 208
LEU A 197
 None
 1.09A 1i9gA-5y50A:
undetectable		 1i9gA-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Sulfolobus
acidocaldarius) 		no annotation 5 GLY A  24
GLY A  26
SER A  27
ALA A  31
VAL A  89
 None
 1.21A 1i9gA-5yeqA:
4.9		 1i9gA-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cim V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 5 ILE B 256
GLY B 221
SER B 259
LEU B 219
LEU B 200
 None
 0.93A 1i9gA-6cimB:
undetectable		 1i9gA-6cimB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 GLY C 991
SER C 992
ALA C 996
LEU C 997
LEU C1024
 None
 0.94A 1i9gA-6en4C:
undetectable		 1i9gA-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esb CAPSID PROTEIN VP1

(Human
polyomavirus 1) 		no annotation 5 ILE 1 288
GLY 1 156
ALA 1 112
ASP 1 198
LEU 1 197
 None
 1.17A 1i9gA-6esb1:
undetectable		 1i9gA-6esb1:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dot DUCK OVOTRANSFERRIN

(Anas
platyrhynchos) 		PF00405
(Transferrin) 		3 GLU A  80
HIS A 250
ASP A 302
 None
FE  A 687 (-3.2A)
None
 0.79A 1i9gA-1dotA:
undetectable		 1i9gA-1dotA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 GLU A 188
HIS A 190
ASP A 176
 None
 0.82A 1i9gA-1eovA:
undetectable		 1i9gA-1eovA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		3 GLU A  80
HIS A 253
ASP A 302
 None
 0.83A 1i9gA-1i6qA:
undetectable		 1i9gA-1i6qA:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		3 GLU A 131
HIS A 136
ASP A 178
 SAM  A 301 (-2.6A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
 0.00A 1i9gA-1i9gA:
42.1		 1i9gA-1i9gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 GLU A 413
HIS A 597
ASP A 645
 None
FE  A 694 ( 3.6A)
None
 0.87A 1i9gA-1n76A:
undetectable		 1i9gA-1n76A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE

(Pyrococcus
furiosus) 		PF00152
(tRNA-synt_2) 		3 GLU A 101
HIS A 110
ASP A  52
 None
 0.79A 1i9gA-1nnhA:
undetectable		 1i9gA-1nnhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 GLU A  80
HIS A 250
ASP A 302
 None
FE  A 333 ( 3.5A)
None
 0.78A 1i9gA-1nntA:
undetectable		 1i9gA-1nntA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		3 GLU A 262
HIS A 146
ASP A 333
 None
 0.85A 1i9gA-1tjyA:
5.4		 1i9gA-1tjyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3

(Bos taurus) 		PF00022
(Actin) 		3 GLU A 280
HIS A 284
ASP A 237
 None
 0.85A 1i9gA-1u2vA:
undetectable		 1i9gA-1u2vA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		3 GLU A 115
HIS A 110
ASP A 913
 None
 0.76A 1i9gA-1uf2A:
undetectable		 1i9gA-1uf2A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		3 GLU A 121
HIS A 137
ASP A 146
 MN  A1238 (-2.7A)
MN  A1238 (-3.5A)
None
 0.87A 1i9gA-1v6mA:
undetectable		 1i9gA-1v6mA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1b CRTF-RELATED PROTEIN

(Chlorobaculum
tepidum) 		PF00891
(Methyltransf_2) 		3 GLU A 147
HIS A 150
ASP A 175
 SAH  A4261 (-2.7A)
SAH  A4261 (-3.6A)
None
 0.85A 1i9gA-1x1bA:
12.9		 1i9gA-1x1bA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		3 GLU A 346
HIS A 403
ASP A 299
 None
 0.78A 1i9gA-1x3lA:
4.8		 1i9gA-1x3lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		3 GLU A  78
HIS A  77
ASP A 427
 None
 0.50A 1i9gA-1z6tA:
undetectable		 1i9gA-1z6tA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoq INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		3 GLU A 310
HIS A 290
ASP A 314
 None
 0.69A 1i9gA-1zoqA:
undetectable		 1i9gA-1zoqA:
23.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		3 GLU A 135
HIS A 140
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-4.0A)
SAM  A 601 (-3.5A)
 0.19A 1i9gA-2b25A:
25.8		 1i9gA-2b25A:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 GLU X 425
HIS X 424
ASP X 432
 None
 0.85A 1i9gA-2b5dX:
undetectable		 1i9gA-2b5dX:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 GLU A  80
HIS A 250
ASP A 302
 None
AL  A 687 ( 3.3A)
None
 0.84A 1i9gA-2d3iA:
undetectable		 1i9gA-2d3iA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		3 GLU A 391
HIS A 356
ASP A 416
 None
ZN  A 601 (-3.3A)
None
 0.73A 1i9gA-2h1nA:
undetectable		 1i9gA-2h1nA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 GLU A 222
HIS A 219
ASP A 112
 None
 0.89A 1i9gA-2i3aA:
3.6		 1i9gA-2i3aA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		3 GLU A 510
HIS A 474
ASP A 467
 None
ZN  A 679 (-3.4A)
None
 0.88A 1i9gA-2o3eA:
undetectable		 1i9gA-2o3eA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		3 GLU A  52
HIS A  50
ASP A 102
 None
 0.77A 1i9gA-2o7pA:
2.1		 1i9gA-2o7pA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 340
HIS A 342
ASP A 288
 None
 0.73A 1i9gA-2ox4A:
undetectable		 1i9gA-2ox4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p11 HYPOTHETICAL PROTEIN

(Paraburkholderia
xenovorans) 		no annotation 3 GLU A 148
HIS A 146
ASP A  16
 None
 0.85A 1i9gA-2p11A:
2.1		 1i9gA-2p11A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Arabidopsis
thaliana) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 GLU A 227
HIS A 224
ASP A 114
 None
 0.81A 1i9gA-2q49A:
3.4		 1i9gA-2q49A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 GLU A 230
HIS A 233
ASP A 167
 ZN  A 431 ( 4.0A)
ZN  A 431 (-3.3A)
None
 0.81A 1i9gA-2qn0A:
undetectable		 1i9gA-2qn0A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
halodurans) 		PF00268
(Ribonuc_red_sm) 		3 GLU A 185
HIS A 222
ASP A  93
 None
 0.81A 1i9gA-2rccA:
undetectable		 1i9gA-2rccA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl3 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus sp.
DK17) 		PF00903
(Glyoxalase) 		3 GLU A 263
HIS A 212
ASP A 281
 FE  A1289 (-2.7A)
FE  A1289 (-3.6A)
None
 0.77A 1i9gA-2wl3A:
undetectable		 1i9gA-2wl3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		3 GLU A  85
HIS A  87
ASP A 251
 None
FUC  A1591 (-4.0A)
None
 0.82A 1i9gA-2wmhA:
undetectable		 1i9gA-2wmhA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 GLU A  15
HIS A  12
ASP A  26
 None
 0.78A 1i9gA-2xr1A:
3.2		 1i9gA-2xr1A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a77 INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		3 GLU A 310
HIS A 290
ASP A 314
 None
 0.73A 1i9gA-3a77A:
undetectable		 1i9gA-3a77A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ago RIBONUCLEASE U2

(Ustilago
sphaerogena) 		PF00545
(Ribonuclease) 		3 GLU A  62
HIS A  41
ASP A 108
 3AM  A 115 (-2.9A)
3AM  A 115 (-3.8A)
3AM  A 115 (-2.9A)
 0.68A 1i9gA-3agoA:
undetectable		 1i9gA-3agoA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 3 GLU A 391
HIS A 356
ASP A 416
 None
ZN  A 565 (-3.4A)
None
 0.78A 1i9gA-3ahmA:
undetectable		 1i9gA-3ahmA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6a TERMINASE LARGE
SUBUNIT

(Escherichia
virus RB49) 		PF17289
(Terminase_6C) 		3 GLU A 519
HIS A 537
ASP A 398
 None
None
MG  A   1 (-3.1A)
 0.84A 1i9gA-3c6aA:
undetectable		 1i9gA-3c6aA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695

(Pyrococcus
furiosus) 		PF01814
(Hemerythrin)
PF13596
(PAS_10) 		3 GLU A 304
HIS A 301
ASP A 344
 None
 0.80A 1i9gA-3caxA:
undetectable		 1i9gA-3caxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		3 GLU A 299
HIS A 421
ASP A 245
 None
 0.77A 1i9gA-3cc1A:
undetectable		 1i9gA-3cc1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 GLU A  88
HIS A  30
ASP A  15
 None
 0.64A 1i9gA-3d6bA:
undetectable		 1i9gA-3d6bA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 GLU A 234
HIS A 237
ASP A 296
 None
 0.86A 1i9gA-3decA:
2.4		 1i9gA-3decA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2v 3'-5'-EXONUCLEASE

(Saccharomyces
cerevisiae) 		PF01026
(TatD_DNase) 		3 GLU A 185
HIS A 114
ASP A  47
 MG  A 427 ( 4.5A)
None
None
 0.85A 1i9gA-3e2vA:
undetectable		 1i9gA-3e2vA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLU A 398
HIS A 432
ASP A 385
 None
 0.88A 1i9gA-3etcA:
undetectable		 1i9gA-3etcA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gw4 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		PF13424
(TPR_12) 		3 GLU A  93
HIS A  71
ASP A 103
 None
 0.53A 1i9gA-3gw4A:
undetectable		 1i9gA-3gw4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		3 GLU A 194
HIS A 231
ASP A 100
 FE  A 401 (-2.5A)
FE  A 401 (-3.2A)
None
 0.73A 1i9gA-3hf1A:
undetectable		 1i9gA-3hf1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		3 GLU A 228
HIS A 231
ASP A 100
 FE  A 401 (-2.9A)
FE  A 401 (-3.2A)
None
 0.79A 1i9gA-3hf1A:
undetectable		 1i9gA-3hf1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		3 GLU A 350
HIS A 379
ASP A 337
 None
 0.88A 1i9gA-3ivrA:
3.1		 1i9gA-3ivrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfo NUCLEOPORIN NUP133

(Saccharomyces
cerevisiae) 		no annotation 3 GLU A1012
HIS A1060
ASP A1067
 None
 0.69A 1i9gA-3kfoA:
undetectable		 1i9gA-3kfoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLU A 345
HIS A 378
ASP A 332
 None
 0.78A 1i9gA-3lgxA:
2.2		 1i9gA-3lgxA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		3 GLU A  83
HIS A 249
ASP A 297
 None
 0.81A 1i9gA-3mc2A:
undetectable		 1i9gA-3mc2A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mj9 JUNCTIONAL ADHESION
MOLECULE-LIKE

(Mus musculus) 		PF07686
(V-set) 		3 GLU A  19
HIS A  16
ASP A 198
 None
 0.88A 1i9gA-3mj9A:
undetectable		 1i9gA-3mj9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		3 GLU A 391
HIS A 528
ASP A 466
 MN  A 680 (-3.9A)
None
None
 0.86A 1i9gA-3mwtA:
undetectable		 1i9gA-3mwtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR

(Legionella
pneumophila) 		PF14860
(DrrA_P4M) 		3 GLU A 631
HIS A 496
ASP A 577
 None
 0.85A 1i9gA-3n6oA:
undetectable		 1i9gA-3n6oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		3 GLU A 340
HIS A 348
ASP A 273
 None
 0.74A 1i9gA-3p2cA:
undetectable		 1i9gA-3p2cA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		3 GLU A 101
HIS A 110
ASP A  52
 None
 0.81A 1i9gA-3p8tA:
undetectable		 1i9gA-3p8tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		3 GLU A  92
HIS A  97
ASP A  65
 None
 0.88A 1i9gA-3td9A:
2.9		 1i9gA-3td9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfw PUTATIVE
O-METHYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF01596
(Methyltransf_3) 		3 GLU A  93
HIS A  98
ASP A 141
 None
 0.34A 1i9gA-3tfwA:
19.8		 1i9gA-3tfwA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgq HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 GLU A 106
HIS A 105
ASP A 113
 None
 0.88A 1i9gA-3tgqA:
undetectable		 1i9gA-3tgqA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Bacillus
anthracis) 		PF02525
(Flavodoxin_2) 		3 GLU A 161
HIS A 164
ASP A 154
 None
CL  A 222 (-4.8A)
None
 0.60A 1i9gA-3u7iA:
undetectable		 1i9gA-3u7iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLU A  57
HIS A  60
ASP A 396
 None
 0.78A 1i9gA-3urhA:
2.8		 1i9gA-3urhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 GLU A1567
HIS A1568
ASP A3053
 None
 0.76A 1i9gA-3vkgA:
undetectable		 1i9gA-3vkgA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		3 GLU A 373
HIS A 408
ASP A 360
 None
 0.83A 1i9gA-3wv4A:
undetectable		 1i9gA-3wv4A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP

(Staphylococcus
aureus) 		no annotation 3 GLU A  39
HIS A  24
ASP A  42
 None
 0.76A 1i9gA-4ae5A:
undetectable		 1i9gA-4ae5A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atf BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 GLU A 184
HIS A 215
ASP A 173
 GAL  A1357 (-4.1A)
GAL  A1357 (-3.3A)
GAL  A1357 (-2.8A)
 0.74A 1i9gA-4atfA:
undetectable		 1i9gA-4atfA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A 195
HIS A 201
ASP A  87
 None
None
CK7  A1285 (-4.0A)
 0.87A 1i9gA-4b9dA:
undetectable		 1i9gA-4b9dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bax GLUTAMINE SYNTHETASE

(Streptomyces
coelicolor) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 GLU A 318
HIS A 237
ASP A 298
 None
 0.77A 1i9gA-4baxA:
undetectable		 1i9gA-4baxA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		3 GLU A1008
HIS A 934
ASP A 807
 None
None
J82  A2000 ( 4.9A)
 0.79A 1i9gA-4bfrA:
undetectable		 1i9gA-4bfrA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		3 GLU A 231
HIS A 234
ASP A 239
 None
 0.84A 1i9gA-4bokA:
undetectable		 1i9gA-4bokA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bws THIOREDOXIN-LIKE
PROTEIN 4A

(Homo sapiens) 		PF02966
(DIM1) 		3 GLU A  65
HIS A   9
ASP A  33
 None
 0.81A 1i9gA-4bwsA:
undetectable		 1i9gA-4bwsA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		3 GLU A 461
HIS A 115
ASP A 577
 None
 0.87A 1i9gA-4c3oA:
undetectable		 1i9gA-4c3oA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		3 GLU A 497
HIS A 556
ASP A 481
 None
 0.63A 1i9gA-4czwA:
undetectable		 1i9gA-4czwA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		3 GLU A 413
HIS A 595
ASP A 643
 None
FE  A 701 ( 3.4A)
None
 0.77A 1i9gA-4fimA:
undetectable		 1i9gA-4fimA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 3 GLU A 160
HIS A 157
ASP A  81
 None
 0.76A 1i9gA-4h5yA:
undetectable		 1i9gA-4h5yA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		3 GLU A 273
HIS A 292
ASP A 247
 None
 0.80A 1i9gA-4hy3A:
6.0		 1i9gA-4hy3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		3 GLU A 220
HIS A 218
ASP A 178
 None
 0.89A 1i9gA-4impA:
7.2		 1i9gA-4impA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN

(Mus musculus) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		3 GLU A 186
HIS A 182
ASP A 165
 None
 0.86A 1i9gA-4m4dA:
undetectable		 1i9gA-4m4dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4k HYDROXYLAMINE
OXIDOREDUCTASE

(Candidatus
Kuenenia
stuttgartiensis) 		PF13447
(Multi-haem_cyto) 		3 GLU A 265
HIS A 258
ASP A 262
 HEM  A 613 (-3.6A)
HEM  A 612 (-3.3A)
HOA  A 615 (-2.9A)
 0.74A 1i9gA-4n4kA:
undetectable		 1i9gA-4n4kA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqf NUCLEOTIDYLTRANSFERA
SE

(Agrobacterium
fabrum) 		PF05168
(HEPN) 		3 GLU A 199
HIS A 217
ASP A 170
 None
 0.87A 1i9gA-4nqfA:
undetectable		 1i9gA-4nqfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		3 GLU A  12
HIS A 481
ASP A 218
 None
 0.79A 1i9gA-4oetA:
undetectable		 1i9gA-4oetA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl7 ACTIN,THYMOSIN
BETA-4

(Homo sapiens;
Komagataella
phaffii) 		PF00022
(Actin)
PF01290
(Thymosin) 		3 GLU A 259
HIS A 263
ASP A 222
 None
 0.78A 1i9gA-4pl7A:
undetectable		 1i9gA-4pl7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 GLU A 443
HIS A 440
ASP A 465
 None
EDO  A 705 ( 4.0A)
None
 0.87A 1i9gA-4wd1A:
4.3		 1i9gA-4wd1A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE

(Burkholderia
pseudomallei) 		PF01063
(Aminotran_4) 		3 GLU A  39
HIS A  59
ASP A 219
 LLP  A 161 ( 3.9A)
LLP  A 161 ( 4.9A)
None
 0.76A 1i9gA-4whxA:
undetectable		 1i9gA-4whxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt8 RV2671

(Mycobacterium
tuberculosis) 		PF01872
(RibD_C) 		3 GLU A  76
HIS A 105
ASP A  33
 None
 0.83A 1i9gA-4xt8A:
undetectable		 1i9gA-4xt8A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 3 GLU A 150
HIS A 221
ASP A 145
 None
CA  A1101 (-3.5A)
None
 0.75A 1i9gA-5b7iA:
undetectable		 1i9gA-5b7iA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		3 GLU A 244
HIS A 188
ASP A 134
 None
None
T6T  A 501 (-1.9A)
 0.88A 1i9gA-5ci5A:
undetectable		 1i9gA-5ci5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLU A 314
HIS A 309
ASP A 285
 None
 0.86A 1i9gA-5cioA:
undetectable		 1i9gA-5cioA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		3 GLU A  81
HIS A  84
ASP A  50
 None
 0.63A 1i9gA-5e8kA:
undetectable		 1i9gA-5e8kA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 GLU A 212
HIS A 209
ASP A 100
 None
 0.78A 1i9gA-5eioA:
3.6		 1i9gA-5eioA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		3 GLU A 282
HIS A 285
ASP A 247
 None
 0.70A 1i9gA-5ev7A:
undetectable		 1i9gA-5ev7A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6q METALLOTHIOL
TRANSFERASE FOSB 2

(Bacillus
anthracis) 		PF00903
(Glyoxalase) 		3 GLU A 115
HIS A  66
ASP A 100
 ZN  A 201 ( 2.4A)
ZN  A 201 ( 3.2A)
None
 0.85A 1i9gA-5f6qA:
undetectable		 1i9gA-5f6qA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 GLU A 201
HIS A 183
ASP C 666
 None
 0.80A 1i9gA-5g5gA:
undetectable		 1i9gA-5g5gA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giv CARBOXYPEPTIDASE 1

(Deinococcus
radiodurans) 		PF02074
(Peptidase_M32) 		3 GLU A 303
HIS A 266
ASP A 351
 None
ZN  A 601 (-3.4A)
None
 0.59A 1i9gA-5givA:
undetectable		 1i9gA-5givA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guh PIWI

(Bombyx mori) 		PF02170
(PAZ)
PF02171
(Piwi) 		3 GLU A 578
HIS A 573
ASP A 605
 None
 0.53A 1i9gA-5guhA:
undetectable		 1i9gA-5guhA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jem INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		3 GLU A 310
HIS A 290
ASP A 314
 None
 0.68A 1i9gA-5jemA:
undetectable		 1i9gA-5jemA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLU A 417
HIS A 342
ASP A 326
 None
 0.87A 1i9gA-5jjqA:
4.3		 1i9gA-5jjqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpz SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 3 GLU A 518
HIS A 526
ASP A 497
 None
 0.71A 1i9gA-5jpzA:
undetectable		 1i9gA-5jpzA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgo FLAGELLAR BRAKE
PROTEIN YCGR

(Klebsiella
pneumoniae) 		no annotation 3 GLU D  28
HIS D  69
ASP D 140
 None
C2E  D 301 (-3.6A)
C2E  D 302 (-3.7A)
 0.73A 1i9gA-5kgoD:
undetectable		 1i9gA-5kgoD:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 3 GLU A1099
HIS A1096
ASP A1207
 None
 0.72A 1i9gA-5kk5A:
undetectable		 1i9gA-5kk5A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oo7 SLA2

(Chaetomium
thermophilum) 		no annotation 3 GLU A 135
HIS A 133
ASP A 153
 None
 0.82A 1i9gA-5oo7A:
undetectable		 1i9gA-5oo7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tge PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF17289
(Terminase_6C) 		3 GLU A 404
HIS A 427
ASP A 294
 None
 0.76A 1i9gA-5tgeA:
undetectable		 1i9gA-5tgeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vx6 UNCHARACTERIZED
PROTEIN YPFA

(Bacillus
subtilis) 		no annotation 3 GLU A 157
HIS A 160
ASP A 195
 None
 0.88A 1i9gA-5vx6A:
undetectable		 1i9gA-5vx6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		3 GLU A  93
HIS A  95
ASP A  66
 None
 0.63A 1i9gA-5y7oA:
undetectable		 1i9gA-5y7oA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 3 GLU A 449
HIS A 183
ASP A 391
 None
 0.79A 1i9gA-6bljA:
undetectable		 1i9gA-6bljA:
undetectable