SIMILAR PATTERNS OF AMINO ACIDS FOR 1I7Z_C_COCC302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)

(Homo sapiens) 		PF07686
(V-set) 		5 TYR A  34
HIS A  38
TYR A  40
TYR A  53
SER A  95
 None
 1.07A 1i7zC-5b8cA:
21.7		 1i7zC-5b8cA:
39.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 GLU A 692
TYR A 674
PRO A 673
ASP A 691
 None
 1.49A 1i7zD-1c7tA:
1.5		 1i7zD-1c7tA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htq GLUTAMINE SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 GLU A  62
TYR A 100
PRO A  99
ASP A  93
 None
 1.40A 1i7zD-1htqA:
0.0		 1i7zD-1htqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 CO-CHAPERONE PROTEIN
SBA1

(Saccharomyces
cerevisiae) 		no annotation 4 GLU X 129
TYR X 103
PRO X 105
ASP X 126
 None
 1.44A 1i7zD-2cg9X:
1.6		 1i7zD-2cg9X:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dng EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4H

(Mus musculus) 		PF00076
(RRM_1) 		4 GLU A  90
TYR A  41
PRO A  40
ASP A  89
 None
 1.46A 1i7zD-2dngA:
0.5		 1i7zD-2dngA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mj3 IRON-SULFUR CLUSTER
BINDING PROTEIN

(Ehrlichia
chaffeensis) 		PF00111
(Fer2) 		4 GLU A  61
TYR A  57
PRO A  54
ASP A  58
 None
 1.16A 1i7zD-2mj3A:
0.0		 1i7zD-2mj3A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwb CELLULASE

(Tropaeolum
majus) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		4 GLU A 117
TYR A  88
PRO A 172
ASP A  93
 None
 1.49A 1i7zD-2uwbA:
0.1		 1i7zD-2uwbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE

(Agrobacterium
fabrum) 		PF13407
(Peripla_BP_4) 		4 GLU A 244
TYR A 212
PRO A 211
ASP A 213
 None
BDP  A 331 (-3.2A)
None
None
 1.44A 1i7zD-3uugA:
0.0		 1i7zD-3uugA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		4 GLU A 429
TYR A 178
PRO A 180
ASP A 408
 None
 1.44A 1i7zD-4mnrA:
0.4		 1i7zD-4mnrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 GLU A 531
TYR A 266
PRO A 269
ASP A 267
 None
 1.27A 1i7zD-4pfwA:
0.0		 1i7zD-4pfwA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwh ABC TRANSPORTER

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLU A 279
TYR A 247
PRO A 246
ASP A 248
 None
GAL  A 401 ( 3.8A)
None
None
 1.44A 1i7zD-4wwhA:
undetectable		 1i7zD-4wwhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF00955
(HCO3_cotransp) 		4 GLU A 758
TYR A 392
PRO A 391
ASP A 396
 None
 1.32A 1i7zD-4yzfA:
undetectable		 1i7zD-4yzfA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc5 XAA-PRO DIPEPTIDASE

(Homo sapiens) 		no annotation 4 GLU A 131
TYR A 128
PRO A  98
ASP A 130
 None
 1.50A 1i7zD-5mc5A:
0.2		 1i7zD-5mc5A:
17.48