SIMILAR PATTERNS OF AMINO ACIDS FOR 1I7Z_A_COCA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 TYR A 299
TYR A 291
LEU A 266
SER A 284
 None
None
None
MG  A 469 ( 4.4A)
 1.10A 1i7zA-1ao0A:
undetectable		 1i7zA-1ao0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 TYR A 384
LEU A 438
LEU A 177
SER A 234
 SF4  A 466 ( 4.9A)
None
None
None
 1.05A 1i7zA-1ao0A:
undetectable		 1i7zA-1ao0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		4 TYR B 204
TYR B  38
LEU B  32
GLU B  29
 None
 1.02A 1i7zA-1ccwB:
undetectable		 1i7zA-1ccwB:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cfv MONOCLONAL ANTIBODY
FV4155

(Mus musculus) 		PF07686
(V-set) 		4 HIS L  39
TYR L  41
TYR L  54
SER L  96
 None
 0.81A 1i7zA-1cfvL:
20.3		 1i7zA-1cfvL:
64.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dql IGM MEZ
IMMUNOGLOBULIN

(Homo sapiens) 		PF07686
(V-set) 		4 TYR L  36
TYR L  49
LEU L  89
TRP L  95
 None
 0.69A 1i7zA-1dqlL:
20.2		 1i7zA-1dqlL:
59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		4 HIS A 204
TYR A 203
LEU A 236
SER A 232
 None
 1.06A 1i7zA-1h14A:
undetectable		 1i7zA-1h14A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		4 TYR A 262
TYR A 270
LEU A 303
SER A 305
 None
 1.09A 1i7zA-1ia5A:
undetectable		 1i7zA-1ia5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 TYR A  61
LEU A   4
LEU A 156
GLU A  22
 None
 0.97A 1i7zA-1iqrA:
undetectable		 1i7zA-1iqrA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE

(Neurospora
crassa) 		PF10282
(Lactonase) 		4 HIS A 172
LEU A 182
LEU A 159
SER A 161
 None
 1.08A 1i7zA-1jofA:
undetectable		 1i7zA-1jofA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin) 		4 TYR A 377
LEU A 336
LEU A 380
GLU A 306
 None
 1.01A 1i7zA-1ldkA:
undetectable		 1i7zA-1ldkA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lk3 9D7 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 HIS L  33
TYR L  35
TYR L  48
SER L  90
 None
 0.85A 1i7zA-1lk3L:
26.8		 1i7zA-1lk3L:
67.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lmk ANTI-PHOSPHATIDYLINO
SITOL SPECIFIC
PHOSPHOLIPASE C
DIABODY

(Mus musculus) 		PF07686
(V-set) 		4 HIS A 239
TYR A 241
TYR A 254
SER A 296
 None
 0.66A 1i7zA-1lmkA:
15.6		 1i7zA-1lmkA:
53.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		4 TYR A 197
LEU A 187
LEU A  55
SER A 208
 None
 1.08A 1i7zA-1ltzA:
undetectable		 1i7zA-1ltzA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbs MYOGLOBIN

(Phoca vitulina) 		PF00042
(Globin) 		4 LEU A   9
LEU A  76
GLU A 122
TRP A  14
 None
 1.12A 1i7zA-1mbsA:
undetectable		 1i7zA-1mbsA:
18.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mi5 TCR ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		5 TYR D  88
LEU D  82
LEU D 112
SER D  12
GLU D  15
 None
 1.21A 1i7zA-1mi5D:
13.8		 1i7zA-1mi5D:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 HIS A 222
LEU A 227
SER A 186
GLU A 163
 None
 1.11A 1i7zA-1mzrA:
undetectable		 1i7zA-1mzrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1na3 DESIGNED PROTEIN
CTPR2

(unidentified) 		PF13432
(TPR_16) 		4 TYR A  26
LEU A  10
LEU A  33
SER A   3
 None
 0.97A 1i7zA-1na3A:
undetectable		 1i7zA-1na3A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1na3 DESIGNED PROTEIN
CTPR2

(unidentified) 		PF13432
(TPR_16) 		4 TYR A  60
LEU A  44
LEU A  67
GLU A  32
 None
 1.03A 1i7zA-1na3A:
undetectable		 1i7zA-1na3A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		no annotation 4 HIS A  54
TYR A  59
LEU A  55
GLU A  14
 None
 0.93A 1i7zA-1odfA:
undetectable		 1i7zA-1odfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		4 HIS X 139
LEU X 185
LEU X 143
SER X  75
 None
 0.98A 1i7zA-1pp1X:
undetectable		 1i7zA-1pp1X:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		4 TYR A 148
LEU A 166
LEU A 151
SER A  86
 None
 1.01A 1i7zA-1qyiA:
undetectable		 1i7zA-1qyiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhx CONSERVED
HYPOTHETICAL PROTEIN
TM0979

(Thermotoga
maritima) 		PF04077
(DsrH) 		4 HIS A  12
LEU A  30
LEU A   3
GLU A  15
 None
 0.78A 1i7zA-1rhxA:
undetectable		 1i7zA-1rhxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfn CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF05899
(Cupin_3) 		4 TYR A1237
LEU A1191
SER A1115
GLU A1118
 None
 0.97A 1i7zA-1sfnA:
undetectable		 1i7zA-1sfnA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szp DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 TYR A 286
LEU A 303
SER A 281
GLU A 182
 None
 0.93A 1i7zA-1szpA:
undetectable		 1i7zA-1szpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin)
PF01290
(Thymosin) 		4 TYR G  59
LEU G  41
LEU G 138
TRP G  88
 None
 1.09A 1i7zA-1t44G:
undetectable		 1i7zA-1t44G:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 TYR A 395
TYR A 387
LEU A 392
GLU A 385
 None
 1.00A 1i7zA-1t8tA:
undetectable		 1i7zA-1t8tA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuw TETRACENOMYCIN
POLYKETIDE SYNTHESIS
PROTEIN TCMI

(Streptomyces
glaucescens) 		PF04673
(Cyclase_polyket) 		4 TYR A  49
TYR A  82
LEU A   9
GLU A  77
 None
 1.02A 1i7zA-1tuwA:
undetectable		 1i7zA-1tuwA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u53 SECRETED PROTEIN
ASP-2

(Necator
americanus) 		PF00188
(CAP) 		4 TYR A 158
LEU A  22
LEU A 141
GLU A  97
 None
 1.03A 1i7zA-1u53A:
undetectable		 1i7zA-1u53A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 TYR A 358
LEU A 355
LEU A 408
SER A 410
 None
 1.00A 1i7zA-1uagA:
undetectable		 1i7zA-1uagA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Escherichia
coli) 		PF00581
(Rhodanese) 		4 HIS A  45
TYR A  92
LEU A  42
GLU A 138
 None
 1.12A 1i7zA-1urhA:
undetectable		 1i7zA-1urhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 TYR A 296
LEU A 197
LEU A 294
TRP A 284
 GOL  A 602 (-4.5A)
None
None
None
 1.12A 1i7zA-1wf3A:
undetectable		 1i7zA-1wf3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 HIS A 573
TYR A 572
SER A 390
GLU A 457
 None
 1.01A 1i7zA-1z8lA:
undetectable		 1i7zA-1z8lA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		4 TYR A 250
LEU A 343
LEU A 366
GLU A 252
 None
 1.10A 1i7zA-1zzgA:
undetectable		 1i7zA-1zzgA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 HIS L  34
TYR L  36
TYR L  49
LEU L  89
 None
 0.43A 1i7zA-2d7tL:
20.6		 1i7zA-2d7tL:
33.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 HIS A 105
TYR A 206
LEU A   9
GLU A 134
 FMT  A 401 (-4.0A)
None
None
None
 0.84A 1i7zA-2dbyA:
undetectable		 1i7zA-2dbyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 LEU A  50
LEU A 332
GLU A 294
TRP A 338
 None
 0.90A 1i7zA-2dbyA:
undetectable		 1i7zA-2dbyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		4 LEU X 306
LEU X 316
GLU X 477
TRP X 326
 None
 0.77A 1i7zA-2de0X:
undetectable		 1i7zA-2de0X:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE

(Rhizobium sp.
MTP-10005) 		PF04909
(Amidohydro_2) 		4 HIS A 209
LEU A 205
GLU A 153
TRP A 151
 None
 1.07A 1i7zA-2dvuA:
undetectable		 1i7zA-2dvuA:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 TYR L  36
TYR L  49
LEU L  89
TRP L  96
 None
AB0  H6001 (-4.6A)
None
AB0  H6001 (-4.2A)
 0.67A 1i7zA-2e27L:
21.0		 1i7zA-2e27L:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eiz ANTI-LYSOZYME
ANTIBODY FV REGION

(Homo sapiens) 		PF07686
(V-set) 		4 HIS A  34
TYR A  36
TYR A  49
SER A  91
 None
 0.95A 1i7zA-2eizA:
20.9		 1i7zA-2eizA:
64.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 TYR A 477
TYR A 467
LEU A 424
LEU A 472
 None
 1.09A 1i7zA-2g3nA:
undetectable		 1i7zA-2g3nA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		4 LEU A  21
LEU A  14
SER A  39
GLU A  37
 None
 0.78A 1i7zA-2gfnA:
undetectable		 1i7zA-2gfnA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 4 LEU I 416
LEU I 173
GLU I 394
TRP I 460
 None
None
None
NGT  A  21 (-3.7A)
 1.07A 1i7zA-2gk1I:
undetectable		 1i7zA-2gk1I:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm8 TENA HOMOLOG/THI-4
THIAMINASE

(Pyrobaculum
aerophilum) 		PF03070
(TENA_THI-4) 		4 TYR A  85
LEU A  40
LEU A  96
GLU A  91
 None
 1.01A 1i7zA-2gm8A:
undetectable		 1i7zA-2gm8A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jy9 PUTATIVE TRNA
HYDROLASE DOMAIN

(Salmonella
enterica) 		PF00472
(RF-1) 		4 TYR A  52
LEU A  48
SER A  46
GLU A  14
 None
 0.81A 1i7zA-2jy9A:
undetectable		 1i7zA-2jy9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kv2 BLOOM SYNDROME
PROTEIN

(Homo sapiens) 		PF00570
(HRDC) 		4 TYR A  76
LEU A  10
LEU A  73
GLU A  42
 None
 0.98A 1i7zA-2kv2A:
undetectable		 1i7zA-2kv2A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2f APOPTOSIS REGULATOR
BCL-2

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 TYR A 199
LEU A  94
GLU A 197
TRP A 192
 LI0  A1000 (-3.4A)
None
None
None
 1.02A 1i7zA-2o2fA:
undetectable		 1i7zA-2o2fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of7 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 TYR A  78
LEU A 120
LEU A  74
GLU A 127
 None
 1.11A 1i7zA-2of7A:
undetectable		 1i7zA-2of7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP

(Homo sapiens) 		PF01853
(MOZ_SAS) 		4 TYR A 198
TYR A 209
LEU A 224
GLU A 212
 None
 1.01A 1i7zA-2ou2A:
undetectable		 1i7zA-2ou2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 TYR A 464
LEU A 287
LEU A 460
SER A 280
 735  A 469 (-4.6A)
None
735  A 469 (-4.3A)
735  A 469 (-2.8A)
 1.07A 1i7zA-2p54A:
undetectable		 1i7zA-2p54A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 HIS A 267
TYR A 271
LEU A 264
GLU A 131
 None
 1.11A 1i7zA-2r9vA:
undetectable		 1i7zA-2r9vA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR

(Pseudomonas
putida) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 TYR A 170
LEU A 174
GLU A 192
TRP A 194
 None
 1.09A 1i7zA-2uxoA:
undetectable		 1i7zA-2uxoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqh CTPR3Y3

(synthetic
construct) 		PF13414
(TPR_11)
PF13432
(TPR_16) 		4 TYR A  99
LEU A  83
LEU A 106
GLU A  71
 None
None
None
MRD  A1109 (-4.6A)
 1.02A 1i7zA-2wqhA:
undetectable		 1i7zA-2wqhA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00342
(PGI) 		4 HIS A 241
LEU A 233
LEU A 205
TRP A 141
 None
 1.07A 1i7zA-2wu8A:
undetectable		 1i7zA-2wu8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 TYR A 586
LEU A 527
LEU A 582
GLU A 522
 None
 1.02A 1i7zA-2xpzA:
2.4		 1i7zA-2xpzA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 TYR A 771
LEU A 891
SER A 889
GLU A 885
 None
None
None
CL  A1993 (-3.3A)
 1.03A 1i7zA-2xvgA:
undetectable		 1i7zA-2xvgA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 LEU A 157
LEU A 161
GLU A 186
TRP A 194
 HTL  A 827 (-3.9A)
None
None
None
 1.11A 1i7zA-3ahiA:
undetectable		 1i7zA-3ahiA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 LEU A 157
LEU A 161
GLU A 186
TRP A 194
 TPP  A 900 (-4.0A)
None
None
None
 1.08A 1i7zA-3ai7A:
undetectable		 1i7zA-3ai7A:
14.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bgf F26G19 FAB

(Mus musculus) 		no annotation 4 TYR L  86
LEU L  73
LEU L  89
SER L  34
 None
 0.89A 1i7zA-3bgfL:
24.6		 1i7zA-3bgfL:
58.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvm ENTEROTOXIN TYPE C-3

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 HIS A  31
TYR A  28
TYR A  32
LEU A  27
 None
 1.09A 1i7zA-3bvmA:
undetectable		 1i7zA-3bvmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		4 TYR A  37
LEU A 199
LEU A 264
GLU A 257
 None
 1.04A 1i7zA-3cswA:
undetectable		 1i7zA-3cswA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		4 TYR A  67
LEU A 198
LEU A  49
SER A  16
 None
 1.07A 1i7zA-3dhuA:
undetectable		 1i7zA-3dhuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 TYR A 244
LEU A 247
GLU A 210
TRP A 128
 None
 1.11A 1i7zA-3du4A:
undetectable		 1i7zA-3du4A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efz 14-3-3 PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		4 TYR A 154
LEU A 151
LEU A 159
GLU A 120
 SEP  A 265 ( 4.6A)
None
None
None
 0.92A 1i7zA-3efzA:
undetectable		 1i7zA-3efzA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		4 TYR A 160
LEU A 159
LEU A 153
SER A 152
 None
 0.99A 1i7zA-3gwbA:
undetectable		 1i7zA-3gwbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 HIS B 164
TYR B 168
LEU B 160
LEU B 172
 None
 0.88A 1i7zA-3h1lB:
undetectable		 1i7zA-3h1lB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz8 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Neisseria
meningitidis) 		PF13462
(Thioredoxin_4) 		4 TYR A 185
LEU A 202
LEU A  50
GLU A 188
 None
 1.12A 1i7zA-3hz8A:
undetectable		 1i7zA-3hz8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr1 METHIONINE
AMINOPEPTIDASE

(Rickettsia
prowazekii) 		PF00557
(Peptidase_M24) 		4 TYR A 183
TYR A 165
LEU A 181
SER A 179
 None
 0.94A 1i7zA-3mr1A:
undetectable		 1i7zA-3mr1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtv PAPAIN-LIKE CYSTEINE
PROTEASE

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05411
(Peptidase_C32) 		4 HIS A 159
LEU A 168
LEU A 160
GLU A  87
 None
 1.05A 1i7zA-3mtvA:
undetectable		 1i7zA-3mtvA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM

(Rhodopseudomonas
palustris) 		no annotation 4 TYR B  79
LEU B  19
LEU B  75
GLU B 113
 None
 0.84A 1i7zA-3nndB:
undetectable		 1i7zA-3nndB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		4 TYR A 204
LEU A 225
LEU A 208
SER A 228
 None
 1.04A 1i7zA-3ntvA:
undetectable		 1i7zA-3ntvA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		4 LEU A 321
LEU A 285
GLU A 295
TRP A 293
 None
 1.02A 1i7zA-3o82A:
undetectable		 1i7zA-3o82A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc2 SUGAR
3-KETOREDUCTASE

(Actinomadura
kijaniata) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 132
LEU A 104
SER A 312
GLU A 307
 None
 1.08A 1i7zA-3rc2A:
undetectable		 1i7zA-3rc2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 TYR A 549
LEU A 486
LEU A 479
GLU A 586
 None
 1.07A 1i7zA-3tbkA:
undetectable		 1i7zA-3tbkA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tu5 GELSOLIN,PROTEIN
CORDON-BLEU,THYMOSIN
BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin) 		4 TYR B  35
LEU B  17
LEU B 114
TRP B  64
 None
 1.00A 1i7zA-3tu5B:
undetectable		 1i7zA-3tu5B:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01261
(AP_endonuc_2) 		4 TYR A 113
LEU A 159
LEU A 117
GLU A 138
 None
None
None
EDO  A 280 ( 4.1A)
 1.10A 1i7zA-3u0hA:
undetectable		 1i7zA-3u0hA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uzv ANTI-DENGUE MAB 4E11

(Mus musculus) 		PF07686
(V-set) 		4 HIS B 170
TYR B 172
TYR B 185
SER B 227
 None
 0.76A 1i7zA-3uzvB:
16.8		 1i7zA-3uzvB:
33.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyf GSP1P
RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00071
(Ras)
PF00638
(Ran_BP1) 		4 TYR B 223
LEU A 211
SER B 283
GLU B 287
 None
 1.06A 1i7zA-3wyfB:
undetectable		 1i7zA-3wyfB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 TYR A  29
LEU A  25
LEU A  59
GLU A  92
 None
 1.08A 1i7zA-4b09A:
undetectable		 1i7zA-4b09A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		4 HIS A 122
TYR A 127
LEU A 123
GLU A  85
 None
 1.10A 1i7zA-4b46A:
undetectable		 1i7zA-4b46A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn8 REGUCALCIN

(Mus musculus) 		PF08450
(SGL) 		4 HIS A 162
TYR A 180
LEU A 160
LEU A 182
 None
 1.07A 1i7zA-4gn8A:
undetectable		 1i7zA-4gn8A:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h0g 2D10 SCFV

(Mus musculus) 		PF07686
(V-set) 		4 HIS A 178
TYR A 180
TYR A 193
SER A 235
 None
 0.76A 1i7zA-4h0gA:
20.2		 1i7zA-4h0gA:
65.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		PF13181
(TPR_8)
PF13424
(TPR_12) 		4 HIS A  55
LEU A  58
LEU A  81
SER A  51
 None
 1.04A 1i7zA-4houA:
undetectable		 1i7zA-4houA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR

(Streptococcus
pyogenes) 		PF01475
(FUR) 		4 TYR A  37
TYR A  51
LEU A  63
SER A  46
 None
 0.91A 1i7zA-4i7hA:
undetectable		 1i7zA-4i7hA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN

(Saccharomyces
cerevisiae) 		PF00248
(Aldo_ket_red) 		4 LEU A 174
LEU A 105
SER A 112
TRP A  69
 None
 1.10A 1i7zA-4ijrA:
undetectable		 1i7zA-4ijrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw2 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 LEU A 227
LEU A 266
SER A 262
GLU A 218
 None
 1.07A 1i7zA-4kw2A:
undetectable		 1i7zA-4kw2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6

(Saccharomyces
cerevisiae) 		PF01423
(LSM) 		4 HIS D  55
LEU D  63
LEU D  33
SER D  35
 None
 1.12A 1i7zA-4m75D:
undetectable		 1i7zA-4m75D:
16.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ma3 C2095 LIGHT CHAIN

(Homo sapiens;
Oryctolagus
cuniculus) 		no annotation 4 TYR L  37
TYR L  50
LEU L  90
SER L  92
 None
 0.54A 1i7zA-4ma3L:
27.5		 1i7zA-4ma3L:
76.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 TYR A  88
LEU A 225
LEU A  86
SER A 220
 None
 1.05A 1i7zA-4my5A:
undetectable		 1i7zA-4my5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		4 TYR A  92
LEU A  95
SER A 174
GLU A  73
 None
None
None
2Q2  A 403 (-2.8A)
 1.08A 1i7zA-4o8mA:
undetectable		 1i7zA-4o8mA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3

(Homo sapiens) 		PF10189
(Ints3) 		4 HIS A 219
TYR A 212
LEU A 225
LEU A 215
 None
 1.12A 1i7zA-4owtA:
undetectable		 1i7zA-4owtA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		4 TYR A 152
TYR A 146
LEU A 142
LEU A 156
 None
 0.99A 1i7zA-4p0vA:
undetectable		 1i7zA-4p0vA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR

(Escherichia
coli) 		PF00392
(GntR)
PF07729
(FCD) 		4 HIS A 144
TYR A 143
LEU A 140
GLU A 153
 None
 0.97A 1i7zA-4p9fA:
undetectable		 1i7zA-4p9fA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 TYR A 262
TYR A 142
LEU A 120
GLU A 105
 None
None
None
2UF  A 401 (-2.8A)
 1.01A 1i7zA-4pbqA:
undetectable		 1i7zA-4pbqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pys BETA-N-ACETYLHEXOSAM
INIDASE

(Bacteroides
fragilis) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 LEU A 180
SER A 151
GLU A 455
TRP A 178
 None
 1.11A 1i7zA-4pysA:
undetectable		 1i7zA-4pysA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TYR A 161
LEU A 200
GLU A 143
TRP A 193
 None
 1.10A 1i7zA-4q1vA:
undetectable		 1i7zA-4q1vA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE

(Plasmodium
vivax) 		PF00082
(Peptidase_S8) 		4 TYR A 534
LEU A 286
LEU A 290
GLU A 282
 None
 1.05A 1i7zA-4tr2A:
undetectable		 1i7zA-4tr2A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf4 CARBOXYPEPTIDASE A1

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 TYR A 308
TYR A 387
LEU A  96
GLU A  91
 None
 1.11A 1i7zA-4uf4A:
undetectable		 1i7zA-4uf4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 HIS A 128
TYR A 152
LEU A 126
GLU A 132
 None
 1.05A 1i7zA-4ufsA:
undetectable		 1i7zA-4ufsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		4 TYR A   4
LEU A 348
LEU A   7
SER A  11
 None
 1.08A 1i7zA-4wu0A:
undetectable		 1i7zA-4wu0A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htq GLUTAMINE SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 GLU A  62
TYR A 100
PRO A  99
ASP A  93
 None
 1.40A 1i7zB-1htqA:
0.2		 1i7zB-1htqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe4 NEUROTOXIN CN11

(Centruroides
noxius) 		PF00537
(Toxin_3) 		4 TYR A  46
TYR A   4
PRO A   5
ASP A   2
 None
 1.48A 1i7zB-1pe4A:
undetectable		 1i7zB-1pe4A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2b CYTOHESIN 3

(Mus musculus) 		PF00169
(PH) 		4 TYR A 296
GLU A 298
PRO A 305
ASP A 302
 SO4  A 501 (-4.8A)
None
None
None
 1.46A 1i7zB-1u2bA:
0.0		 1i7zB-1u2bA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		4 TYR B 247
GLU B  96
TYR B  92
ASP B  93
 None
 1.23A 1i7zB-1y56B:
0.0		 1i7zB-1y56B:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 TYR A 227
TYR A 220
PRO A  45
ASP A 221
 None
 1.37A 1i7zB-2fuqA:
2.0		 1i7zB-2fuqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mj3 IRON-SULFUR CLUSTER
BINDING PROTEIN

(Ehrlichia
chaffeensis) 		PF00111
(Fer2) 		4 GLU A  61
TYR A  57
PRO A  54
ASP A  58
 None
 1.17A 1i7zB-2mj3A:
0.0		 1i7zB-2mj3A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		4 TYR A 295
GLU A 297
PRO A 304
ASP A 301
 4IP  A 405 (-4.5A)
None
None
SO4  A 404 (-4.2A)
 1.47A 1i7zB-2r09A:
0.0		 1i7zB-2r09A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vow SURFACE-ASSOCIATED
PROTEIN

(Methylococcus
capsulatus) 		no annotation 4 TYR A 243
TYR A 233
PRO A 234
ASP A 229
 None
 1.30A 1i7zB-2vowA:
0.5		 1i7zB-2vowA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		4 TYR A  34
GLU A  27
TYR A 305
PRO A 302
 None
 1.37A 1i7zB-2xu0A:
undetectable		 1i7zB-2xu0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 TYR A  34
GLU A  27
TYR A 305
PRO A 302
 None
 1.39A 1i7zB-2yk0A:
undetectable		 1i7zB-2yk0A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brz TODX

(Pseudomonas
putida) 		PF03349
(Toluene_X) 		4 TYR A 330
GLU A 276
PRO A 327
ASP A 309
 None
 1.44A 1i7zB-3brzA:
undetectable		 1i7zB-3brzA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 132
GLU A  24
TYR A  23
ASP A  22
 None
 1.37A 1i7zB-3dkhA:
2.0		 1i7zB-3dkhA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7t ENVELOPE PROTEIN

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 TYR A 326
GLU A 362
PRO A 332
ASP A 360
 None
 1.21A 1i7zB-3g7tA:
4.4		 1i7zB-3g7tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7m SENSOR PROTEIN

(Geobacter
sulfurreducens) 		PF00497
(SBP_bac_3) 		4 TYR A  69
TYR A  66
PRO A  67
ASP A  63
 None
 1.46A 1i7zB-3h7mA:
undetectable		 1i7zB-3h7mA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 133
GLU A  25
TYR A  24
ASP A  23
 None
 1.39A 1i7zB-3ppsA:
undetectable		 1i7zB-3ppsA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE

(Rhodospirillum
rubrum) 		PF01261
(AP_endonuc_2) 		4 TYR A  77
GLU A 267
PRO A 162
ASP A 194
 None
FE  A 301 ( 2.6A)
None
FE  A 301 ( 3.2A)
 1.19A 1i7zB-3qxbA:
undetectable		 1i7zB-3qxbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyx ESX-1
SECRETION-ASSOCIATED
REGULATOR ESPR

(Mycobacterium
tuberculosis) 		no annotation 4 TYR A  75
GLU A  83
TYR A  82
ASP A  79
 None
 1.50A 1i7zB-3qyxA:
undetectable		 1i7zB-3qyxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 TYR A 638
GLU A 647
TYR A 620
ASP A 621
 None
 1.33A 1i7zB-3wiqA:
2.9		 1i7zB-3wiqA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF14488
(DUF4434)
PF17134
(DUF5109) 		4 TYR A 349
GLU A 338
PRO A  73
ASP A  66
 None
 1.49A 1i7zB-4h41A:
undetectable		 1i7zB-4h41A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		4 GLU A 429
TYR A 178
PRO A 180
ASP A 408
 None
 1.45A 1i7zB-4mnrA:
undetectable		 1i7zB-4mnrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n31 SIPA

(Streptococcus
pyogenes) 		PF10502
(Peptidase_S26) 		4 TYR A 116
GLU A 145
TYR A 142
ASP A  48
 None
 1.25A 1i7zB-4n31A:
undetectable		 1i7zB-4n31A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 GLU A 531
TYR A 266
PRO A 269
ASP A 267
 None
 1.31A 1i7zB-4pfwA:
undetectable		 1i7zB-4pfwA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF00955
(HCO3_cotransp) 		4 GLU A 758
TYR A 392
PRO A 391
ASP A 396
 None
 1.39A 1i7zB-4yzfA:
undetectable		 1i7zB-4yzfA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Rhinovirus C) 		PF00073
(Rhv) 		4 TYR C 144
TYR A 185
PRO A 188
ASP A 186
 None
 1.50A 1i7zB-5k0uC:
1.3		 1i7zB-5k0uC:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 TYR A 723
TYR A 706
PRO A 704
ASP A 708
 None
 1.13A 1i7zB-5m59A:
4.0		 1i7zB-5m59A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwl INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Mus musculus) 		PF06090
(Ins_P5_2-kin) 		4 TYR A 337
GLU A 334
TYR A 450
ASP A 453
 None
 1.14A 1i7zB-5mwlA:
undetectable		 1i7zB-5mwlA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 TYR A 377
GLU A 391
PRO A 386
ASP A 390
 None
 1.44A 1i7zB-5no8A:
6.2		 1i7zB-5no8A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES4
RIBOSOMAL PROTEIN
ES6

(Toxoplasma
gondii) 		PF00467
(KOW)
PF00900
(Ribosomal_S4e)
PF01092
(Ribosomal_S6e)
PF01479
(S4)
PF08071
(RS4NT)
PF16121
(40S_S4_C) 		4 TYR G 206
GLU G 202
TYR E 149
PRO E 150
 None
 1.23A 1i7zB-5xxuG:
undetectable		 1i7zB-5xxuG:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 4 TYR A 295
GLU A 297
PRO A 304
ASP A 301
 4IP  A 603 (-4.5A)
None
None
None
 1.37A 1i7zB-6bbpA:
undetectable		 1i7zB-6bbpA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens) 		no annotation 4 TYR B 340
TYR B 344
PRO B 147
ASP B 145
 None
 1.48A 1i7zB-6d6uB:
2.1		 1i7zB-6d6uB:
15.45