SIMILAR PATTERNS OF AMINO ACIDS FOR 1I7Q_C_BEZC1502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 ILE A  44
GLY A 179
THR A 180
HIS A 152
GLY A 176
 None
PLP  A 501 (-3.9A)
PLP  A 501 (-3.6A)
None
PLP  A 501 (-3.5A)
 1.10A 1i7qC-1d6sA:
undetectable		 1i7qC-1d6sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 ILE A  93
GLY A 448
THR A  91
GLY A 127
GLU A 417
 None
 1.38A 1i7qC-1dq3A:
undetectable		 1i7qC-1dq3A:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 ILE A 326
GLY A 328
THR A 329
GLU A 358
HIS A 398
 None
 1.10A 1i7qC-1i1qA:
54.5		 1i7qC-1i1qA:
71.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		10 GLU A 309
ILE A 326
GLY A 328
THR A 329
GLU A 361
HIS A 398
ARG A 469
GLY A 485
GLU A 498
LYS A 502
 BEZ  A1501 (-3.8A)
BEZ  A1501 (-3.9A)
BEZ  A1501 (-3.3A)
BEZ  A1501 (-3.9A)
MG  A1701 ( 3.1A)
BEZ  A1501 ( 4.2A)
PYR  A1601 ( 3.9A)
BEZ  A1501 (-3.8A)
MG  A1701 ( 2.6A)
BEZ  A1501 ( 2.9A)
 0.15A 1i7qC-1i7qA:
65.7		 1i7qC-1i7qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		6 GLU A 309
ILE A 326
THR A 329
HIS A 398
GLY A 483
GLU A 498
 BEZ  A1501 (-3.8A)
BEZ  A1501 (-3.9A)
BEZ  A1501 (-3.9A)
BEZ  A1501 ( 4.2A)
PYR  A1601 (-3.8A)
MG  A1701 ( 2.6A)
 1.41A 1i7qC-1i7qA:
65.7		 1i7qC-1i7qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 258
ARG A 410
GLY A 426
GLU A 439
LYS A 443
 None
 1.06A 1i7qC-1k0gA:
37.3		 1i7qC-1k0gA:
31.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqz MCMV M144

(Murid
betaherpesvirus
1) 		PF07654
(C1-set) 		5 GLU A  36
GLY A  31
THR A  30
HIS A  32
GLY A  48
 None
 1.35A 1i7qC-1pqzA:
2.1		 1i7qC-1pqzA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 225
ILE A 240
GLY A 242
GLU A 269
HIS A 306
 None
 0.98A 1i7qC-1qdlA:
40.0		 1i7qC-1qdlA:
33.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 225
ILE A 240
GLY A 242
THR A 243
HIS A 306
 None
 0.34A 1i7qC-1qdlA:
40.0		 1i7qC-1qdlA:
33.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 ILE A 158
GLY A 160
THR A 161
GLU A  48
GLY A  47
 None
 1.28A 1i7qC-2cfmA:
undetectable		 1i7qC-2cfmA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		5 ILE A 188
GLY A 186
THR A 193
GLU A 185
GLY A 212
 None
 1.45A 1i7qC-2g8lA:
undetectable		 1i7qC-2g8lA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus;
Lupinus luteus) 		PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2) 		5 ILE B 289
GLY B 287
THR B 243
HIS A   9
GLY B 305
 None
 1.20A 1i7qC-2gezB:
undetectable		 1i7qC-2gezB:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 5 GLY A 204
THR A 205
HIS A 248
GLY A 181
LYS A 250
 None
 1.35A 1i7qC-2iouA:
undetectable		 1i7qC-2iouA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		8 GLU A 240
GLY A 257
THR A 258
HIS A 318
ARG A 387
GLY A 403
GLU A 416
LYS A 420
 None
 0.67A 1i7qC-3bzmA:
38.0		 1i7qC-3bzmA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 137
GLY A 307
THR A 311
HIS A 116
GLY A 283
 None
 1.40A 1i7qC-3d46A:
undetectable		 1i7qC-3d46A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 137
GLY A 308
THR A 311
HIS A 116
GLY A 283
 None
 1.49A 1i7qC-3d46A:
undetectable		 1i7qC-3d46A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		5 GLU A 258
GLY A 275
THR A 276
GLU A 302
HIS A 336
 None
 0.47A 1i7qC-3gseA:
32.9		 1i7qC-3gseA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kqf ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		5 ILE A 141
GLY A 144
GLU A 116
ARG A  73
GLY A 113
 None
 1.12A 1i7qC-3kqfA:
undetectable		 1i7qC-3kqfA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
horikoshii) 		PF03833
(PolC_DP2) 		5 ILE X 236
GLY X 238
GLU X 240
HIS X 183
GLU X 220
 None
 1.13A 1i7qC-3o59X:
undetectable		 1i7qC-3o59X:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		7 GLU A 197
GLY A 214
HIS A 276
ARG A 348
GLY A 364
GLU A 377
LYS A 381
 None
SO4  A 404 (-3.8A)
None
None
SO4  A 404 (-3.8A)
SO4  A 404 (-4.1A)
SO4  A 404 (-2.9A)
 0.57A 1i7qC-3os6A:
25.0		 1i7qC-3os6A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		5 ILE A  91
GLY A 228
THR A 229
HIS A 201
GLY A 225
 None
P1T  A 702 (-3.9A)
P1T  A 702 (-3.6A)
None
P1T  A 702 (-3.6A)
 1.09A 1i7qC-3pc3A:
undetectable		 1i7qC-3pc3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		9 GLU A 201
ILE A 216
GLY A 218
THR A 219
GLU A 244
HIS A 279
ARG A 352
GLU A 382
LYS A 386
 BEZ  A 701 ( 4.3A)
BEZ  A 701 (-4.2A)
BEZ  A 701 (-3.5A)
BEZ  A 701 (-4.0A)
MG  A 700 ( 2.5A)
BEZ  A 701 (-3.8A)
PYR  A 702 ( 3.9A)
MG  A 700 ( 2.5A)
PYR  A 702 ( 3.1A)
 0.39A 1i7qC-3r75A:
33.9		 1i7qC-3r75A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7b ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00331
(Glyco_hydro_10) 		5 THR A  22
GLU A  29
HIS A  68
GLY A 286
GLU A  45
 None
 1.42A 1i7qC-3u7bA:
undetectable		 1i7qC-3u7bA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE

(Xenopus laevis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A 218
GLY A 222
THR A 221
GLU A 283
ARG A 440
 None
None
SO4  A 501 (-4.1A)
None
SO4  A 501 (-3.4A)
 1.43A 1i7qC-3w0lA:
undetectable		 1i7qC-3w0lA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		5 GLU A  14
GLY A  17
THR A  20
GLY A  40
GLU A 220
 MLI  A 502 (-4.7A)
MLI  A 502 (-3.2A)
None
MLI  A 502 (-4.8A)
None
 1.09A 1i7qC-4m9dA:
undetectable		 1i7qC-4m9dA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofx CYSTATHIONINE
BETA-SYNTHASE

(Coxiella
burnetii) 		PF00291
(PALP) 		5 ILE A  46
GLY A 183
THR A 184
HIS A 156
GLY A 180
 None
 1.13A 1i7qC-4ofxA:
undetectable		 1i7qC-4ofxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Phaseolus
vulgaris;
Phaseolus
vulgaris) 		PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2) 		5 ILE B 292
GLY B 290
THR B 246
HIS A   9
GLY B 308
 None
None
ASP  B 501 (-3.6A)
None
None
 1.19A 1i7qC-4pu6B:
undetectable		 1i7qC-4pu6B:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		6 GLU A 307
ILE A 322
GLY A 324
THR A 325
HIS A 388
GLY A 475
 0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.2A)
None
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
None
 0.68A 1i7qC-5cwaA:
41.2		 1i7qC-5cwaA:
38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 307
ILE A 322
THR A 325
HIS A 388
GLY A 474
 0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.2A)
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
0GA  A 604 ( 4.4A)
 0.95A 1i7qC-5cwaA:
41.2		 1i7qC-5cwaA:
38.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hst POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		5 GLU A 157
ILE A 153
GLY A 218
THR A 217
GLY A 222
 None
 1.17A 1i7qC-5hstA:
undetectable		 1i7qC-5hstA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		9 GLU A 240
GLY A 257
THR A 258
GLU A 284
HIS A 321
ARG A 391
GLY A 407
GLU A 420
LYS A 424
 None
ACT  A 503 (-3.2A)
ACT  A 503 (-3.7A)
FE2  A 501 ( 2.7A)
ACT  A 503 ( 4.1A)
ACT  A 502 (-3.5A)
ACT  A 503 (-3.8A)
FE2  A 501 ( 2.8A)
ACT  A 503 ( 2.3A)
 0.26A 1i7qC-5jy9A:
42.3		 1i7qC-5jy9A:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzd ISOCHORISMATE
SYNTHASE ENTC

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		8 GLU A 197
GLY A 214
GLU A 241
HIS A 276
ARG A 347
GLY A 363
GLU A 376
LYS A 380
 ISC  A 401 (-3.0A)
ISC  A 401 (-3.2A)
MG  A 402 ( 2.4A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.3A)
MG  A 402 ( 2.6A)
ISC  A 401 (-3.0A)
 0.45A 1i7qC-5jzdA:
24.5		 1i7qC-5jzdA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mms CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		5 ILE A 122
GLY A 259
THR A 260
HIS A 232
GLY A 256
 None
PLP  A1002 ( 4.0A)
PLP  A1002 (-3.5A)
None
PLP  A1002 (-3.6A)
 1.07A 1i7qC-5mmsA:
undetectable		 1i7qC-5mmsA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLU A 193
ILE A 414
GLY A 417
THR A 407
GLY A 198
 None
 1.24A 1i7qC-5nv3A:
undetectable		 1i7qC-5nv3A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohx CYSTATHIONINE
BETA-SYNTHASE

(Apis mellifera) 		no annotation 5 ILE A  81
GLY A 218
THR A 219
HIS A 191
GLY A 215
 None
PLP  A 702 (-3.6A)
PLP  A 702 (-4.1A)
None
PLP  A 702 (-3.4A)
 1.06A 1i7qC-5ohxA:
undetectable		 1i7qC-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 5 GLU A 711
ILE A 966
GLY A 968
GLU A  91
LYS A 622
 None
 1.15A 1i7qC-5wblA:
undetectable		 1i7qC-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A  56
GLY A 199
THR A 200
HIS A 167
GLY A 196
 None
PLP  A 401 (-3.9A)
PLP  A 401 (-3.5A)
None
PLP  A 401 (-3.6A)
 1.11A 1i7qC-6c2hA:
undetectable		 1i7qC-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 ILE A 362
GLY A 360
GLU A 358
HIS A 338
GLY A 356
 None
 1.49A 1i7qC-6cjbA:
undetectable		 1i7qC-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi) 		no annotation 5 GLU A 195
ILE A 416
GLY A 419
THR A 409
GLY A 200
 None
None
None
None
LYO  A 198 ( 4.4A)
 1.29A 1i7qC-6ftlA:
undetectable		 1i7qC-6ftlA:
undetectable