SIMILAR PATTERNS OF AMINO ACIDS FOR 1I6V_C_RFPC1640
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zsq | MYOTUBULARIN-RELATEDPROTEIN 2 (Homo sapiens) |
PF02893(GRAM)PF06602(Myotub-related) | 5 | ARG A 459HIS A 458ARG A 463SER A 477ILE A 356 | PIB A3632 ( 4.8A)EDO A1878 (-3.9A)PIB A3632 ( 3.8A)NonePIB A3632 (-3.9A) | 1.30A | 1i6vC-1zsqA:0.2 | 1i6vC-1zsqA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2put | ISOMERASE DOMAIN OFGLUTAMINE-FRUCTOSE-6-PHOSPHATETRANSAMINASE(ISOMERIZING) (Candidaalbicans) |
PF01380(SIS) | 5 | GLN A 463LEU A 466ARG A 397GLU A 428ILE A 401 | None | 1.46A | 1i6vC-2putA:0.0 | 1i6vC-2putA:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hkz | DNA-DIRECTED RNAPOLYMERASE SUBUNIT B (Sulfolobussolfataricus) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 5 | LEU B 226PHE B 253ASP B 235ARG B 228ILE B 262 | None | 1.28A | 1i6vC-3hkzB:16.6 | 1i6vC-3hkzB:29.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rr1 | PUTATIVED-GALACTONATEDEHYDRATASE (Ralstoniapickettii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ARG A 236ASP A 258HIS A 261GLU A 31ILE A 34 | None | 1.24A | 1i6vC-3rr1A:0.0 | 1i6vC-3rr1A:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sk1 | EHPR (Pantoeaagglomerans) |
PF00903(Glyoxalase) | 5 | ASP A 119HIS A 121ARG A 69GLU A 66ILE A 67 | None | 1.38A | 1i6vC-3sk1A:0.7 | 1i6vC-3sk1A:7.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va8 | PROBABLE DEHYDRATASE (Fusariumgraminearum) |
PF13378(MR_MLE_C) | 5 | GLN A 287LEU A 314SER A 280GLU A 250ILE A 251 | None | 1.36A | 1i6vC-3va8A:0.0 | 1i6vC-3va8A:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vte | TETRAHYDROCANNABINOLIC ACID SYNTHASE (Cannabis sativa) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | GLN A 145LEU A 248ASP A 202ARG A 231ILE A 205 | None | 1.21A | 1i6vC-3vteA:undetectable | 1i6vC-3vteA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dal | PUTATIVE ALDEHYDEDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00171(Aldedh) | 5 | LEU A 159PHE A 110ASP A 106GLU A 75ILE A 74 | None | 1.27A | 1i6vC-4dalA:0.0 | 1i6vC-4dalA:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jmu | GAG-POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00540(Gag_p17) | 5 | LEU A 68GLN A 65ARG A 58GLU A 107ILE A 104 | None | 1.43A | 1i6vC-4jmuA:undetectable | 1i6vC-4jmuA:9.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nv7 | ARYLAMINEN-ACETYLTRANSFERASE (Mesorhizobiumjaponicum) |
PF00797(Acetyltransf_2) | 5 | PHE A 163ASP A 180ARG A 110ARG A 97ILE A 107 | None | 1.49A | 1i6vC-4nv7A:0.0 | 1i6vC-4nv7A:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xh9 | NEUROEPITHELIALCELL-TRANSFORMINGGENE 1 PROTEIN (Homo sapiens) |
PF00169(PH)PF00621(RhoGEF) | 5 | ARG A 292LEU A 290ASP A 202ARG A 197ILE A 218 | None | 1.44A | 1i6vC-4xh9A:undetectable | 1i6vC-4xh9A:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yff | SERINE/THREONINE-PROTEIN KINASE TNNI3K (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | GLN A 614LEU A 613ASP A 588GLU A 509ILE A 512 | None | 1.46A | 1i6vC-4yffA:undetectable | 1i6vC-4yffA:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zu4 | WXCM-LIKE PROTEIN (Shewanelladenitrificans) |
PF05523(FdtA) | 5 | GLN A 228LEU A 261ASP A 198HIS A 178ILE A 231 | 4TG A 401 (-3.2A)NoneNoneNoneNone | 1.05A | 1i6vC-4zu4A:undetectable | 1i6vC-4zu4A:8.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zys | EXOTOXIN 6 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 5 | ARG A 165LEU A 103ASP A 99SER A 115ILE A 80 | None | 1.46A | 1i6vC-4zysA:undetectable | 1i6vC-4zysA:11.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tw1 | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Mycolicibacteriumsmegmatis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF10385(RNA_pol_Rpb2_45) | 10 | ARG C 164GLN C 426LEU C 427GLN C 429ASP C 432ARG C 604HIS C 442ARG C 445SER C 447ILE C 488 | None | 1.04A | 1i6vC-5tw1C:37.2 | 1i6vC-5tw1C:50.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tw1 | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Mycolicibacteriumsmegmatis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF10385(RNA_pol_Rpb2_45) | 7 | GLN C 429PHE C 430ARG C 604HIS C 442ARG C 445SER C 447ILE C 488 | None | 1.35A | 1i6vC-5tw1C:37.2 | 1i6vC-5tw1C:50.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6el1 | YAXB (Yersiniaenterocolitica) |
no annotation | 5 | GLN O 34LEU O 48SER O 51GLU O 290ILE O 29 | None | 1.37A | 1i6vC-6el1O:undetectable | 1i6vC-6el1O:5.85 |