SIMILAR PATTERNS OF AMINO ACIDS FOR 1I3W_G_DVAG2_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)


(Pseudomonas
fluorescens)
PF01494
(FAD_binding_3)
3 THR A 192
PRO A 194
THR A 217
None
0.81A 1i3wG-1cj2A:
undetectable
1i3wG-1cj2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.)
PF00067
(p450)
3 THR A 109
PRO A 107
THR A 111
None
0.70A 1i3wG-1cptA:
undetectable
1i3wG-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT


(Desulfovibrio
desulfuricans)
PF00374
(NiFeSe_Hases)
3 THR B 493
PRO B 491
THR B 492
None
FNE  B 543 (-3.7A)
FNE  B 543 (-3.8A)
0.81A 1i3wG-1e3dB:
undetectable
1i3wG-1e3dB:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei)
PF00840
(Glyco_hydro_7)
3 THR A   5
PRO A   8
THR A   7
None
0.86A 1i3wG-1eg1A:
undetectable
1i3wG-1eg1A:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME


(Homo sapiens)
PF00390
(malic)
PF03949
(Malic_M)
3 THR A 115
PRO A 109
THR A 113
None
0.88A 1i3wG-1gz4A:
undetectable
1i3wG-1gz4A:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H  64
PRO H  60
THR H  62
None
0.80A 1i3wG-1h3pH:
undetectable
1i3wG-1h3pH:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE


(Sus scrofa)
PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21)
3 THR A 555
PRO A 553
THR A 554
None
0.78A 1i3wG-1h7wA:
undetectable
1i3wG-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE


(Homo sapiens)
PF13460
(NAD_binding_10)
3 THR A 166
PRO A 201
THR A 199
None
0.83A 1i3wG-1he3A:
undetectable
1i3wG-1he3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
3 THR A 149
PRO A 146
THR A 147
None
0.87A 1i3wG-1j3uA:
undetectable
1i3wG-1j3uA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
3 THR A  97
PRO A  95
THR A  99
None
0.77A 1i3wG-1jioA:
undetectable
1i3wG-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)


(Escherichia
coli)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1)
3 THR A 687
PRO A 614
THR A 688
None
0.81A 1i3wG-1qafA:
undetectable
1i3wG-1qafA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus)
PF13242
(Hydrolase_like)
3 THR A 245
PRO A 241
THR A 243
None
0.80A 1i3wG-1qyiA:
undetectable
1i3wG-1qyiA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS


(Escherichia
coli)
PF01614
(IclR)
3 THR A 100
PRO A  98
THR A  99
None
0.87A 1i3wG-1tf1A:
undetectable
1i3wG-1tf1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Arabidopsis
thaliana)
PF00903
(Glyoxalase)
3 THR A  95
PRO A  93
THR A  94
None
0.83A 1i3wG-1tg5A:
undetectable
1i3wG-1tg5A:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujt KIAA1568 PROTEIN

(Homo sapiens)
PF00041
(fn3)
3 THR A 111
PRO A  29
THR A 112
None
0.86A 1i3wG-1ujtA:
undetectable
1i3wG-1ujtA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
3 THR A1032
PRO A1034
THR A1035
None
0.82A 1i3wG-1ux6A:
undetectable
1i3wG-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI


(Homo sapiens)
PF00089
(Trypsin)
3 THR A  36
PRO A  37
THR A  37
None
0.85A 1i3wG-1zlrA:
undetectable
1i3wG-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
3 THR C  37
PRO C  36
THR C 241
None
0.83A 1i3wG-1zrtC:
undetectable
1i3wG-1zrtC:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
3 THR A 106
PRO A   2
THR A 107
None
0.86A 1i3wG-2b42A:
undetectable
1i3wG-2b42A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c34 INHIBITOR OF
CYSTEINE PEPTIDASES


(Leishmania
mexicana)
PF09394
(Inhibitor_I42)
3 THR A  32
PRO A  30
THR A  31
None
0.86A 1i3wG-2c34A:
undetectable
1i3wG-2c34A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE


(Phanerochaete
chrysosporium)
no annotation 3 THR A 252
PRO A 100
THR A  98
None
0.88A 1i3wG-2cl2A:
undetectable
1i3wG-2cl2A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)


(Streptomyces
galilaeus)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 THR A 392
PRO A 388
THR A 390
None
0.87A 1i3wG-2ipiA:
undetectable
1i3wG-2ipiA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnu REGULATORY PROTEIN
E2


(Alphapapillomavirus
9)
PF00508
(PPV_E2_N)
3 THR A 104
PRO A 106
THR A 107
None
0.77A 1i3wG-2nnuA:
undetectable
1i3wG-2nnuA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF16073
(SAT)
3 THR B  56
PRO B  54
THR B  55
None
0.76A 1i3wG-2pffB:
undetectable
1i3wG-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A


(Geobacillus
stearothermophilus)
PF00005
(ABC_tran)
3 THR A 857
PRO A 855
THR A 856
None
0.87A 1i3wG-2r6fA:
undetectable
1i3wG-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE


(Rhodococcus
jostii)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
3 THR A 237
PRO A 235
THR A 236
None
0.84A 1i3wG-2rfqA:
undetectable
1i3wG-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs5 HUMAN RHINOVIRUS 14
COAT PROTEIN
(SUBUNIT VP2)


(Rhinovirus B)
PF00073
(Rhv)
3 THR 2 145
PRO 2 149
THR 2 147
None
0.82A 1i3wG-2rs52:
undetectable
1i3wG-2rs52:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN


(Rattus
norvegicus)
PF00012
(HSP70)
3 THR A  66
PRO A  63
THR A  64
None
0.85A 1i3wG-2v7zA:
undetectable
1i3wG-2v7zA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens)
PF07679
(I-set)
PF13927
(Ig_3)
3 THR A 230
PRO A 186
THR A 228
None
0.75A 1i3wG-2v9qA:
undetectable
1i3wG-2v9qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgr GLUTATHIONE
PEROXIDASE


(Schistosoma
mansoni)
PF00255
(GSHPx)
3 THR A 153
PRO A 151
THR A 152
None
POP  A1170 (-4.4A)
None
0.87A 1i3wG-2wgrA:
undetectable
1i3wG-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2


(Streptomyces
fradiae)
PF08659
(KR)
3 THR A  37
PRO A  35
THR A  36
None
0.77A 1i3wG-2z5lA:
undetectable
1i3wG-2z5lA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Homo sapiens)
PF01593
(Amino_oxidase)
3 THR A 278
PRO A 274
THR A 276
None
FAD  A 600 ( 4.9A)
None
0.78A 1i3wG-2z5xA:
undetectable
1i3wG-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE


(Bifidobacterium
longum)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
3 THR A 113
PRO A 117
THR A 115
None
0.86A 1i3wG-3ai7A:
undetectable
1i3wG-3ai7A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT


(Hydrogenovibrio
marinus)
PF00374
(NiFeSe_Hases)
3 THR A 547
PRO A 545
THR A 546
None
CYN  A 605 ( 3.6A)
CYN  A 605 (-3.7A)
0.78A 1i3wG-3ayxA:
undetectable
1i3wG-3ayxA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3


(Saccharomyces
cerevisiae)
PF03571
(Peptidase_M49)
3 THR A 236
PRO A 240
THR A 238
None
0.84A 1i3wG-3cskA:
undetectable
1i3wG-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens)
PF00626
(Gelsolin)
3 THR A 704
PRO A 700
THR A 702
None
0.84A 1i3wG-3fg6A:
undetectable
1i3wG-3fg6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ


(Carboxydothermus
hydrogenoformans)
PF14450
(FtsA)
3 THR A 166
PRO A 165
THR A 147
None
0.80A 1i3wG-3h1qA:
undetectable
1i3wG-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
3 THR A 108
PRO A   4
THR A 109
None
0.85A 1i3wG-3hd8A:
undetectable
1i3wG-3hd8A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Herpetosiphon
aurantiacus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 THR A   4
PRO A   2
THR A   3
None
0.87A 1i3wG-3ik4A:
undetectable
1i3wG-3ik4A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00476
(DNA_pol_A)
3 THR A 638
PRO A 635
THR A 636
None
0.74A 1i3wG-3ikmA:
undetectable
1i3wG-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE


(Listeria
monocytogenes)
PF00171
(Aldedh)
3 THR A 124
PRO A 121
THR A 122
None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
0.85A 1i3wG-3k9dA:
undetectable
1i3wG-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
3 THR A  21
PRO A  19
THR A  20
None
0.87A 1i3wG-3kh5A:
undetectable
1i3wG-3kh5A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus)
PF04199
(Cyclase)
3 THR A  48
PRO A 195
THR A  46
None
0.85A 1i3wG-3krvA:
undetectable
1i3wG-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE


(Yersinia pestis)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 139
PRO A 136
THR A 137
None
0.86A 1i3wG-3lxmA:
undetectable
1i3wG-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei)
PF13847
(Methyltransf_31)
3 THR A 254
PRO A 150
THR A 248
None
0.86A 1i3wG-3mggA:
undetectable
1i3wG-3mggA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE


(Vibrio
parahaemolyticus)
PF00171
(Aldedh)
3 THR A 119
PRO A 116
THR A 117
None
CL  A 453 ( 4.6A)
CL  A 453 ( 4.4A)
0.85A 1i3wG-3my7A:
undetectable
1i3wG-3my7A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE


(Taxus
canadensis)
PF00221
(Lyase_aromatic)
3 THR A 129
PRO A 125
THR A 127
None
0.73A 1i3wG-3nz4A:
undetectable
1i3wG-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
3 THR A  70
PRO A 425
THR A  69
None
0.87A 1i3wG-3oksA:
undetectable
1i3wG-3oksA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II


(Streptococcus
suis)
PF00155
(Aminotran_1_2)
3 THR A 154
PRO A 152
THR A 153
None
0.84A 1i3wG-3op7A:
undetectable
1i3wG-3op7A:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens)
PF13927
(Ig_3)
3 THR A 367
PRO A 366
THR A 410
None
0.83A 1i3wG-3p40A:
undetectable
1i3wG-3p40A:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua)
PF00294
(PfkB)
3 THR A 270
PRO A 266
THR A 268
None
0.77A 1i3wG-3q1yA:
undetectable
1i3wG-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT


(Mycobacterium
marinum)
PF00202
(Aminotran_3)
3 THR A  69
PRO A 424
THR A  68
None
0.86A 1i3wG-3r4tA:
undetectable
1i3wG-3r4tA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG


(Cupriavidus
necator)
PF00374
(NiFeSe_Hases)
3 THR L 554
PRO L 552
THR L 553
None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
0.79A 1i3wG-3rgwL:
undetectable
1i3wG-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)


(Triticum
aestivum)
PF00450
(Peptidase_S10)
3 THR B 346
PRO B 342
THR B 344
None
0.68A 1i3wG-3sc2B:
undetectable
1i3wG-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN


(Escherichia
coli)
PF00374
(NiFeSe_Hases)
3 THR L 533
PRO L 531
THR L 532
None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
0.76A 1i3wG-3uscL:
undetectable
1i3wG-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsu TLL2057 PROTEIN

(Thermosynechococcus
elongatus)
no annotation 3 THR A 105
PRO A 102
THR A 103
None
0.87A 1i3wG-3zsuA:
undetectable
1i3wG-3zsuA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1r LIP

(Serratia
marcescens)
PF12790
(T6SS-SciN)
3 THR A 145
PRO A 142
THR A 143
None
0.87A 1i3wG-4a1rA:
undetectable
1i3wG-4a1rA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP


(Thermotoga
maritima)
PF03030
(H_PPase)
3 THR A 423
PRO A 420
THR A 421
None
0.83A 1i3wG-4av6A:
undetectable
1i3wG-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8)
no annotation 3 THR A 297
PRO A 299
THR A 295
None
0.69A 1i3wG-4btpA:
undetectable
1i3wG-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC


(Homo sapiens)
PF00063
(Myosin_head)
PF00612
(IQ)
3 THR A 647
PRO A 649
THR A 650
None
0.80A 1i3wG-4byfA:
undetectable
1i3wG-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT


(Salmonella
enterica)
PF00374
(NiFeSe_Hases)
3 THR A 536
PRO A 534
THR A 535
None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
0.80A 1i3wG-4c3oA:
undetectable
1i3wG-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
3 THR A 248
PRO A 252
THR A 250
None
0.83A 1i3wG-4dzaA:
undetectable
1i3wG-4dzaA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF09455
(Cas_DxTHG)
3 THR A 176
PRO A 173
THR A 174
None
0.84A 1i3wG-4eogA:
undetectable
1i3wG-4eogA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2


(Danio rerio)
PF03372
(Exo_endo_phos)
3 THR A 211
PRO A 209
THR A 210
None
0.72A 1i3wG-4f1hA:
undetectable
1i3wG-4f1hA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
caccae)
PF07523
(Big_3)
PF13306
(LRR_5)
3 THR A 217
PRO A 192
THR A 193
None
0.84A 1i3wG-4fd0A:
undetectable
1i3wG-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)


(Mycobacteroides
abscessus)
PF00202
(Aminotran_3)
3 THR A  73
PRO A 423
THR A  72
None
0.86A 1i3wG-4ffcA:
undetectable
1i3wG-4ffcA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB


(Geobacillus
stearothermophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
3 THR A 268
PRO A 186
THR A 187
None
0.88A 1i3wG-4fnqA:
undetectable
1i3wG-4fnqA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
3 THR A 148
PRO A 145
THR A 149
P6G  A 305 ( 4.5A)
None
None
0.81A 1i3wG-4h16A:
undetectable
1i3wG-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k24 ANTI-UPAR ANTIBODY,
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H 117
PRO H 147
THR H 116
None
0.78A 1i3wG-4k24H:
undetectable
1i3wG-4k24H:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2j OSMOTIN: ANTIFUNGAL
LATICIFER PROTEIN


(Calotropis
procera)
PF00314
(Thaumatin)
3 THR A 189
PRO A 186
THR A 187
None
0.87A 1i3wG-4l2jA:
undetectable
1i3wG-4l2jA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
3 THR A 308
PRO A 306
THR A 310
None
0.79A 1i3wG-4lmpA:
undetectable
1i3wG-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Chromohalobacter
salexigens)
PF03480
(DctP)
3 THR A 202
PRO A 198
THR A 200
None
0.84A 1i3wG-4n8gA:
undetectable
1i3wG-4n8gA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Alicyclobacillus
acidocaldarius)
PF13416
(SBP_bac_8)
3 THR A 259
PRO A 255
THR A 257
None
0.81A 1i3wG-4ovjA:
undetectable
1i3wG-4ovjA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae)
PF01095
(Pectinesterase)
3 THR A 111
PRO A 113
THR A 143
None
0.79A 1i3wG-4pmhA:
undetectable
1i3wG-4pmhA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN


(Pectobacterium
atrosepticum)
PF13416
(SBP_bac_8)
3 THR A 301
PRO A 303
THR A 165
None
0.82A 1i3wG-4ry1A:
undetectable
1i3wG-4ry1A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME


(Bacillus cereus)
PF00704
(Glyco_hydro_18)
PF01476
(LysM)
3 THR A 166
PRO A 168
THR A 162
None
0.81A 1i3wG-4s3jA:
undetectable
1i3wG-4s3jA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans)
PF00730
(HhH-GPD)
3 THR A 150
PRO A 154
THR A 152
None
0.87A 1i3wG-4uobA:
undetectable
1i3wG-4uobA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens)
PF03283
(PAE)
3 THR A 282
PRO A 287
THR A 284
None
0.85A 1i3wG-4uz1A:
undetectable
1i3wG-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
3 THR A 305
PRO A 302
THR A 303
None
0.87A 1i3wG-4wzbA:
undetectable
1i3wG-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnz LIGHT CHAIN OF
ANTIBODY VRC06B


(Homo sapiens)
no annotation 3 THR L  97
PRO L   8
THR L  10
None
0.87A 1i3wG-4xnzL:
undetectable
1i3wG-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)


(Chaetomium)
PF13472
(Lipase_GDSL_2)
3 THR A 285
PRO A 287
THR A 288
None
0.71A 1i3wG-4xvhA:
undetectable
1i3wG-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw8 UBIQUITIN-LIKE
PROTEIN MDY2


(Saccharomyces
cerevisiae)
PF16843
(Get5_bdg)
3 THR D  23
PRO D  25
THR D  21
None
0.76A 1i3wG-5bw8D:
undetectable
1i3wG-5bw8D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum)
PF00026
(Asp)
3 THR A 116
PRO A 113
THR A 114
None
0.81A 1i3wG-5bwyA:
undetectable
1i3wG-5bwyA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
3 THR D1946
PRO D1943
THR D1944
None
0.76A 1i3wG-5disD:
undetectable
1i3wG-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis)
PF03415
(Peptidase_C11)
3 THR B 282
PRO B 278
THR B 388
None
0.81A 1i3wG-5dynB:
undetectable
1i3wG-5dynB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI


(Homo sapiens)
PF00024
(PAN_1)
PF00089
(Trypsin)
3 THR A 390
PRO A 392
THR A 393
None
0.76A 1i3wG-5eodA:
undetectable
1i3wG-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris)
PF12783
(Sec7_N)
PF16213
(DCB)
3 THR A  64
PRO A  62
THR A  66
None
0.70A 1i3wG-5hasA:
undetectable
1i3wG-5hasA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB


(Bacillus
subtilis)
PF01638
(HxlR)
3 THR A  39
PRO A  43
THR A  41
None
0.66A 1i3wG-5hs8A:
undetectable
1i3wG-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Burkholderia
vietnamiensis)
PF00483
(NTP_transferase)
3 THR A  56
PRO A  83
THR A  81
None
0.80A 1i3wG-5ifyA:
undetectable
1i3wG-5ifyA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)


(Parageobacillus
thermoglucosidasius)
PF00171
(Aldedh)
3 THR A 146
PRO A 143
THR A 144
None
ACT  A1005 (-3.9A)
ACT  A1005 (-3.3A)
0.82A 1i3wG-5j78A:
undetectable
1i3wG-5j78A:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE


(Rhodopseudomonas
palustris)
PF00171
(Aldedh)
3 THR A 203
PRO A 200
THR A 201
None
0.84A 1i3wG-5jfmA:
undetectable
1i3wG-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31


(Saccharomyces
cerevisiae)
PF01125
(G10)
3 THR L  24
PRO L  21
THR L  22
None
0.87A 1i3wG-5lj3L:
undetectable
1i3wG-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Archaeoglobus
fulgidus)
no annotation 3 THR A 199
PRO A 201
THR A 228
None
None
TAM  A 303 (-3.9A)
0.86A 1i3wG-5mqzA:
undetectable
1i3wG-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron)
PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C)
3 THR A  69
PRO A  67
THR A  68
None
0.85A 1i3wG-5ngkA:
undetectable
1i3wG-5ngkA:
1.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4


(Homo sapiens)
no annotation 3 THR D 388
PRO D 385
THR D 386
None
0.77A 1i3wG-5of4D:
undetectable
1i3wG-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1


(Homo sapiens)
PF01485
(IBR)
3 THR B 131
PRO B 127
THR B 129
None
0.74A 1i3wG-5tteB:
undetectable
1i3wG-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1


(Homo sapiens)
PF01485
(IBR)
3 THR A 131
PRO A 127
THR A 129
None
0.85A 1i3wG-5udhA:
undetectable
1i3wG-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz SCFV

(Homo sapiens)
PF07686
(V-set)
3 THR G 104
PRO G   8
THR G  10
None
0.85A 1i3wG-5ujzG:
undetectable
1i3wG-5ujzG:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
3 THR A 502
PRO A 504
THR A 505
None
0.67A 1i3wG-5w1uA:
undetectable
1i3wG-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)


(Homo sapiens)
no annotation 3 THR A1076
PRO A1073
THR A1074
None
0.84A 1i3wG-6bq1A:
undetectable
1i3wG-6bq1A:
undetectable