SIMILAR PATTERNS OF AMINO ACIDS FOR 1I3W_F_DVAF8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		3 THR A 211
THR A 213
PRO A 210
 None
 0.83A 1i3wF-1c3lA:
undetectable		 1i3wF-1c3lA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 THR A 111
THR A 109
PRO A 107
 None
 0.74A 1i3wF-1cptA:
undetectable		 1i3wF-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		3 THR B 492
THR B 493
PRO B 491
 FNE  B 543 (-3.8A)
None
FNE  B 543 (-3.7A)
 0.77A 1i3wF-1e3dB:
undetectable		 1i3wF-1e3dB:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		3 THR A   7
THR A   5
PRO A   8
 None
 0.83A 1i3wF-1eg1A:
undetectable		 1i3wF-1eg1A:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 THR A 107
THR A 109
PRO A 106
 None
 0.83A 1i3wF-1eu1A:
undetectable		 1i3wF-1eu1A:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		3 THR A 193
THR A 194
PRO A 192
 None
 0.86A 1i3wF-1fuuA:
undetectable		 1i3wF-1fuuA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		3 THR A 554
THR A 555
PRO A 553
 None
 0.72A 1i3wF-1h7wA:
undetectable		 1i3wF-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE

(Homo sapiens) 		PF13460
(NAD_binding_10) 		3 THR A 199
THR A 166
PRO A 201
 None
 0.84A 1i3wF-1he3A:
undetectable		 1i3wF-1he3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 THR A 147
THR A 149
PRO A 146
 None
 0.84A 1i3wF-1j3uA:
undetectable		 1i3wF-1j3uA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 THR A  99
THR A  97
PRO A  95
 None
 0.78A 1i3wF-1jioA:
undetectable		 1i3wF-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		3 THR A 688
THR A 687
PRO A 614
 None
 0.83A 1i3wF-1qafA:
undetectable		 1i3wF-1qafA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		3 THR A  99
THR A 100
PRO A  98
 None
 0.79A 1i3wF-1tf1A:
undetectable		 1i3wF-1tf1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Arabidopsis
thaliana) 		PF00903
(Glyoxalase) 		3 THR A  94
THR A  95
PRO A  93
 None
 0.77A 1i3wF-1tg5A:
undetectable		 1i3wF-1tg5A:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		3 THR A1035
THR A1032
PRO A1034
 None
 0.76A 1i3wF-1ux6A:
undetectable		 1i3wF-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		3 THR A 204
THR A 203
PRO A 230
 None
 0.84A 1i3wF-1w5dA:
undetectable		 1i3wF-1w5dA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		3 THR A  37
THR A  36
PRO A  37
 None
 0.77A 1i3wF-1zlrA:
undetectable		 1i3wF-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 THR C 241
THR C  37
PRO C  36
 None
 0.85A 1i3wF-1zrtC:
undetectable		 1i3wF-1zrtC:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 THR A 107
THR A 106
PRO A   2
 None
 0.85A 1i3wF-2b42A:
undetectable		 1i3wF-2b42A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c34 INHIBITOR OF
CYSTEINE PEPTIDASES

(Leishmania
mexicana) 		PF09394
(Inhibitor_I42) 		3 THR A  31
THR A  32
PRO A  30
 None
 0.79A 1i3wF-2c34A:
undetectable		 1i3wF-2c34A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		3 THR A 164
THR A 165
PRO A 163
 None
 0.83A 1i3wF-2c6rA:
undetectable		 1i3wF-2c6rA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgy POSSIBLE EXPORTED
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 3 THR A  16
THR A  17
PRO A  15
 None
 0.82A 1i3wF-2kgyA:
undetectable		 1i3wF-2kgyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksk SUGARCANE DEFENSIN 5

(Saccharum
officinarum) 		PF00304
(Gamma-thionin) 		3 THR A   4
THR A   2
PRO A   5
 None
 0.83A 1i3wF-2kskA:
undetectable		 1i3wF-2kskA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnu REGULATORY PROTEIN
E2

(Alphapapillomavirus
9) 		PF00508
(PPV_E2_N) 		3 THR A 107
THR A 104
PRO A 106
 None
 0.78A 1i3wF-2nnuA:
undetectable		 1i3wF-2nnuA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		3 THR B  55
THR B  56
PRO B  54
 None
 0.72A 1i3wF-2pffB:
undetectable		 1i3wF-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		3 THR A 856
THR A 857
PRO A 855
 None
 0.80A 1i3wF-2r6fA:
undetectable		 1i3wF-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 THR A 236
THR A 237
PRO A 235
 None
 0.78A 1i3wF-2rfqA:
undetectable		 1i3wF-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs5 HUMAN RHINOVIRUS 14
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus B) 		PF00073
(Rhv) 		3 THR 2 147
THR 2 145
PRO 2 149
 None
 0.80A 1i3wF-2rs52:
undetectable		 1i3wF-2rs52:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		3 THR A  64
THR A  66
PRO A  63
 None
 0.84A 1i3wF-2v7zA:
undetectable		 1i3wF-2v7zA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 THR A 228
THR A 230
PRO A 186
 None
 0.73A 1i3wF-2v9qA:
undetectable		 1i3wF-2v9qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		3 THR A 761
THR A 762
PRO A 760
 None
 0.83A 1i3wF-2vf8A:
undetectable		 1i3wF-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgr GLUTATHIONE
PEROXIDASE

(Schistosoma
mansoni) 		PF00255
(GSHPx) 		3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.79A 1i3wF-2wgrA:
undetectable		 1i3wF-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		3 THR F 587
THR F 588
PRO F 586
 None
 0.83A 1i3wF-2xwbF:
undetectable		 1i3wF-2xwbF:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		3 THR A  36
THR A  37
PRO A  35
 None
 0.73A 1i3wF-2z5lA:
undetectable		 1i3wF-2z5lA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.83A 1i3wF-2z5xA:
undetectable		 1i3wF-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		3 THR A 175
THR A 176
PRO A 174
 None
 0.84A 1i3wF-3a9xA:
undetectable		 1i3wF-3a9xA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		3 THR A 546
THR A 547
PRO A 545
 CYN  A 605 (-3.7A)
None
CYN  A 605 ( 3.6A)
 0.73A 1i3wF-3ayxA:
undetectable		 1i3wF-3ayxA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		3 THR A 122
THR A 123
PRO A 121
 PLP  A 500 (-4.5A)
PLP  A 500 (-4.6A)
None
 0.83A 1i3wF-3bb8A:
undetectable		 1i3wF-3bb8A:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dao PUTATIVE PHOSPHATE

([Eubacterium]
rectale) 		PF08282
(Hydrolase_3) 		3 THR A  80
THR A  69
PRO A  82
 None
 0.85A 1i3wF-3daoA:
undetectable		 1i3wF-3daoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 THR C 187
THR C 188
PRO C 186
 None
 0.84A 1i3wF-3gzdC:
undetectable		 1i3wF-3gzdC:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		3 THR A 147
THR A 166
PRO A 165
 None
 0.83A 1i3wF-3h1qA:
undetectable		 1i3wF-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 THR A 109
THR A 108
PRO A   4
 None
 0.86A 1i3wF-3hd8A:
undetectable		 1i3wF-3hd8A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Herpetosiphon
aurantiacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 THR A   3
THR A   4
PRO A   2
 None
 0.80A 1i3wF-3ik4A:
undetectable		 1i3wF-3ik4A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 THR A 636
THR A 638
PRO A 635
 None
 0.76A 1i3wF-3ikmA:
undetectable		 1i3wF-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq2 SORTING NEXIN-7

(Homo sapiens) 		PF00787
(PX) 		3 THR A 133
THR A 135
PRO A 132
 None
 0.86A 1i3wF-3iq2A:
undetectable		 1i3wF-3iq2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		3 THR A 122
THR A 124
PRO A 121
 CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
 0.82A 1i3wF-3k9dA:
undetectable		 1i3wF-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		3 THR A  20
THR A  21
PRO A  19
 None
 0.80A 1i3wF-3kh5A:
undetectable		 1i3wF-3kh5A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE

(Yersinia pestis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 THR A 137
THR A 139
PRO A 136
 None
 0.81A 1i3wF-3lxmA:
undetectable		 1i3wF-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8l CAPSID PROTEIN

(Feline
calicivirus) 		PF00915
(Calici_coat) 		3 THR A 132
THR A 131
PRO A 133
 None
 0.85A 1i3wF-3m8lA:
undetectable		 1i3wF-3m8lA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF13847
(Methyltransf_31) 		3 THR A 248
THR A 254
PRO A 150
 None
 0.85A 1i3wF-3mggA:
undetectable		 1i3wF-3mggA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		3 THR A 390
THR A 391
PRO A 389
 None
 0.83A 1i3wF-3mpgA:
undetectable		 1i3wF-3mpgA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		3 THR A 117
THR A 119
PRO A 116
 CL  A 453 ( 4.4A)
None
CL  A 453 ( 4.6A)
 0.81A 1i3wF-3my7A:
undetectable		 1i3wF-3my7A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		3 THR A 127
THR A 129
PRO A 125
 None
 0.78A 1i3wF-3nz4A:
undetectable		 1i3wF-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		3 THR A 153
THR A 154
PRO A 152
 None
 0.77A 1i3wF-3op7A:
undetectable		 1i3wF-3op7A:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdm COAT PROTEIN

(Hibiscus latent
Singapore virus) 		PF00721
(TMV_coat) 		3 THR P 103
THR P 104
PRO P 102
 None
 0.82A 1i3wF-3pdmP:
undetectable		 1i3wF-3pdmP:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		3 THR A 268
THR A 270
PRO A 266
 None
 0.85A 1i3wF-3q1yA:
undetectable		 1i3wF-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.75A 1i3wF-3rgwL:
undetectable		 1i3wF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)

(Triticum
aestivum) 		PF00450
(Peptidase_S10) 		3 THR B 344
THR B 346
PRO B 342
 None
 0.73A 1i3wF-3sc2B:
undetectable		 1i3wF-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN

(Escherichia
coli) 		PF00374
(NiFeSe_Hases) 		3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.72A 1i3wF-3uscL:
undetectable		 1i3wF-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1r LIP

(Serratia
marcescens) 		PF12790
(T6SS-SciN) 		3 THR A 143
THR A 145
PRO A 142
 None
 0.85A 1i3wF-4a1rA:
undetectable		 1i3wF-4a1rA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		3 THR A 421
THR A 423
PRO A 420
 None
 0.80A 1i3wF-4av6A:
undetectable		 1i3wF-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 3 THR A 295
THR A 297
PRO A 299
 None
 0.68A 1i3wF-4btpA:
undetectable		 1i3wF-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 THR A 650
THR A 647
PRO A 649
 None
 0.73A 1i3wF-4byfA:
undetectable		 1i3wF-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.76A 1i3wF-4c3oA:
undetectable		 1i3wF-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		3 THR A 174
THR A 176
PRO A 173
 None
 0.83A 1i3wF-4eogA:
undetectable		 1i3wF-4eogA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2

(Danio rerio) 		PF03372
(Exo_endo_phos) 		3 THR A 210
THR A 211
PRO A 209
 None
 0.64A 1i3wF-4f1hA:
undetectable		 1i3wF-4f1hA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 THR A 187
THR A 268
PRO A 186
 None
 0.82A 1i3wF-4fnqA:
undetectable		 1i3wF-4fnqA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.80A 1i3wF-4h16A:
undetectable		 1i3wF-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k24 ANTI-UPAR ANTIBODY,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H 116
THR H 117
PRO H 147
 None
 0.74A 1i3wF-4k24H:
undetectable		 1i3wF-4k24H:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2j OSMOTIN: ANTIFUNGAL
LATICIFER PROTEIN

(Calotropis
procera) 		PF00314
(Thaumatin) 		3 THR A 187
THR A 189
PRO A 186
 None
 0.84A 1i3wF-4l2jA:
undetectable		 1i3wF-4l2jA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae) 		PF01095
(Pectinesterase) 		3 THR A 143
THR A 111
PRO A 113
 None
 0.81A 1i3wF-4pmhA:
undetectable		 1i3wF-4pmhA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 THR A 171
THR A 169
PRO A 172
 None
 0.85A 1i3wF-4qorA:
undetectable		 1i3wF-4qorA:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Pectobacterium
atrosepticum) 		PF13416
(SBP_bac_8) 		3 THR A 165
THR A 301
PRO A 303
 None
 0.86A 1i3wF-4ry1A:
undetectable		 1i3wF-4ry1A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 THR A 162
THR A 166
PRO A 168
 None
 0.85A 1i3wF-4s3jA:
undetectable		 1i3wF-4s3jA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu9 MEDI7814

(Homo sapiens) 		PF07686
(V-set) 		3 THR B  94
THR B  95
PRO B  93
 None
 0.84A 1i3wF-4uu9B:
undetectable		 1i3wF-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens) 		PF03283
(PAE) 		3 THR A 284
THR A 282
PRO A 287
 None
 0.82A 1i3wF-4uz1A:
undetectable		 1i3wF-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		3 THR A 303
THR A 305
PRO A 302
 None
 0.85A 1i3wF-4wzbA:
undetectable		 1i3wF-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)

(Chaetomium) 		PF13472
(Lipase_GDSL_2) 		3 THR A 288
THR A 285
PRO A 287
 None
 0.64A 1i3wF-4xvhA:
undetectable		 1i3wF-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a) 		3 THR C 974
THR C 973
PRO C 975
 None
 0.86A 1i3wF-5a6fC:
undetectable		 1i3wF-5a6fC:
1.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw8 UBIQUITIN-LIKE
PROTEIN MDY2

(Saccharomyces
cerevisiae) 		PF16843
(Get5_bdg) 		3 THR D  21
THR D  23
PRO D  25
 None
 0.81A 1i3wF-5bw8D:
undetectable		 1i3wF-5bw8D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum) 		PF00026
(Asp) 		3 THR A 114
THR A 116
PRO A 113
 None
 0.76A 1i3wF-5bwyA:
undetectable		 1i3wF-5bwyA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		3 THR A1240
THR A1241
PRO A1239
 None
 0.81A 1i3wF-5dacA:
undetectable		 1i3wF-5dacA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		3 THR D1944
THR D1946
PRO D1943
 None
 0.66A 1i3wF-5disD:
undetectable		 1i3wF-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF03415
(Peptidase_C11) 		3 THR B 388
THR B 282
PRO B 278
 None
 0.77A 1i3wF-5dynB:
undetectable		 1i3wF-5dynB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		3 THR A 393
THR A 390
PRO A 392
 None
 0.67A 1i3wF-5eodA:
undetectable		 1i3wF-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foh POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		3 THR A  46
THR A  47
PRO A  23
 None
 0.84A 1i3wF-5fohA:
undetectable		 1i3wF-5fohA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		3 THR A  66
THR A  64
PRO A  62
 None
 0.75A 1i3wF-5hasA:
undetectable		 1i3wF-5hasA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB

(Bacillus
subtilis) 		PF01638
(HxlR) 		3 THR A  41
THR A  39
PRO A  43
 None
 0.70A 1i3wF-5hs8A:
undetectable		 1i3wF-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		3 THR A  81
THR A  56
PRO A  83
 None
 0.83A 1i3wF-5ifyA:
undetectable		 1i3wF-5ifyA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		3 THR A 144
THR A 146
PRO A 143
 ACT  A1005 (-3.3A)
None
ACT  A1005 (-3.9A)
 0.78A 1i3wF-5j78A:
undetectable		 1i3wF-5j78A:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		3 THR A 201
THR A 203
PRO A 200
 None
 0.78A 1i3wF-5jfmA:
undetectable		 1i3wF-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		3 THR A 157
THR A 158
PRO A 156
 None
 0.83A 1i3wF-5k9xA:
undetectable		 1i3wF-5k9xA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31

(Saccharomyces
cerevisiae) 		PF01125
(G10) 		3 THR L  22
THR L  24
PRO L  21
 None
 0.85A 1i3wF-5lj3L:
undetectable		 1i3wF-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Archaeoglobus
fulgidus) 		no annotation 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.86A 1i3wF-5mqzA:
undetectable		 1i3wF-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 THR A  68
THR A  69
PRO A  67
 None
 0.81A 1i3wF-5ngkA:
undetectable		 1i3wF-5ngkA:
1.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4

(Homo sapiens) 		no annotation 3 THR D 386
THR D 388
PRO D 385
 None
 0.73A 1i3wF-5of4D:
undetectable		 1i3wF-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 THR B 129
THR B 131
PRO B 127
 None
 0.81A 1i3wF-5tteB:
undetectable		 1i3wF-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 THR A 427
THR A 428
PRO A 426
 None
 0.86A 1i3wF-5u03A:
undetectable		 1i3wF-5u03A:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		3 THR A 505
THR A 502
PRO A 504
 None
 0.57A 1i3wF-5w1uA:
undetectable		 1i3wF-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 3 THR A1074
THR A1076
PRO A1073
 None
 0.80A 1i3wF-6bq1A:
undetectable		 1i3wF-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 3 THR A1826
THR A1828
PRO A1820
 None
 0.83A 1i3wF-6fb3A:
undetectable		 1i3wF-6fb3A:
undetectable