SIMILAR PATTERNS OF AMINO ACIDS FOR 1I2W_A_CFXA1300_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aei | ANNEXIN XII (Hydra vulgaris) |
PF00191(Annexin) | 4 | TYR A 248LEU A 279THR A 266ARG A 269 | None | 1.19A | 1i2wA-1aeiA:undetectable | 1i2wA-1aeiA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aol | GP70 (Murine leukemiavirus) |
PF00429(TLV_coat) | 4 | TYR A 206LEU A 41THR A 202ARG A 227 | None | 1.28A | 1i2wA-1aolA:undetectable | 1i2wA-1aolA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bk6 | KARYOPHERIN ALPHA (Saccharomycescerevisiae) |
PF00514(Arm)PF16186(Arm_3) | 4 | TYR A 283PRO A 250LEU A 212THR A 236 | None | 1.27A | 1i2wA-1bk6A:undetectable | 1i2wA-1bk6A:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efp | PROTEIN (ELECTRONTRANSFERFLAVOPROTEIN) (Paracoccusdenitrificans) |
PF01012(ETF) | 4 | PRO B 175LEU B 116THR B 145ARG B 161 | None | 1.21A | 1i2wA-1efpB:undetectable | 1i2wA-1efpB:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fbv | SIGNAL TRANSDUCTIONPROTEIN CBL (Homo sapiens) |
PF02262(Cbl_N)PF02761(Cbl_N2)PF02762(Cbl_N3)PF14447(Prok-RING_4) | 4 | TYR A 83PRO A 89THR A 152ARG A 148 | None | 1.15A | 1i2wA-1fbvA:undetectable | 1i2wA-1fbvA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fn4 | MONOCLONAL ANTIBODYAGAINSTACETYLCHOLINERECEPTOR (Rattusnorvegicus) |
PF07654(C1-set)PF07686(V-set) | 4 | PRO A 80LEU A 106THR A 74ARG A 18 | None | 1.27A | 1i2wA-1fn4A:undetectable | 1i2wA-1fn4A:23.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1g68 | BETA-LACTAMASE PSE-4 (Pseudomonasaeruginosa) |
PF13354(Beta-lactamase2) | 4 | TYR A 105PRO A 167LEU A 169ARG A 244 | NoneNoneNoneSO4 A 400 ( 4.6A) | 0.62A | 1i2wA-1g68A:38.2 | 1i2wA-1g68A:32.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hzo | BETA-LACTAMASE (Proteusvulgaris) |
PF13354(Beta-lactamase2) | 4 | TYR A 105PRO A 167LEU A 169THR A 235 | MES A1000 (-3.9A)NoneNoneMES A1000 (-3.7A) | 0.57A | 1i2wA-1hzoA:41.6 | 1i2wA-1hzoA:43.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ic8 | HEPATOCYTE NUCLEARFACTOR 1-ALPHA (Homo sapiens) |
PF00046(Homeobox)PF04814(HNF-1_N) | 4 | PRO A 129LEU A 123THR A 164ARG A 168 | None | 1.39A | 1i2wA-1ic8A:undetectable | 1i2wA-1ic8A:21.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1n9b | BETA-LACTAMASE SHV-2 (Klebsiellapneumoniae) |
PF13354(Beta-lactamase2) | 4 | TYR A 105LEU A 169THR A 235ARG A 244 | EPE A 400 (-3.6A)NoneEPE A 400 (-3.8A)MA4 A 310 ( 3.8A) | 0.39A | 1i2wA-1n9bA:34.6 | 1i2wA-1n9bA:36.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nt4 | GLUCOSE-1-PHOSPHATASE (Escherichiacoli) |
PF00328(His_Phos_2) | 4 | TYR A 218PRO A 23LEU A 24THR A 314 | None | 1.35A | 1i2wA-1nt4A:undetectable | 1i2wA-1nt4A:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pd2 | HEMATOPOIETICPROSTAGLANDIN DSYNTHASE (Rattusnorvegicus) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | PRO 1 125LEU 1 127THR 1 158ARG 1 178 | None | 1.23A | 1i2wA-1pd21:undetectable | 1i2wA-1pd21:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pq4 | PERIPLASMIC BINDINGPROTEIN COMPONENT OFAN ABC TYPE ZINCUPTAKE TRANSPORTER (Synechocystissp. PCC 6803) |
PF01297(ZnuA) | 4 | TYR A 85PRO A 111LEU A 113THR A 52 | None | 1.25A | 1i2wA-1pq4A:undetectable | 1i2wA-1pq4A:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1svc | PROTEIN (NUCLEARFACTOR KAPPA-B(NF-KB)) (Homo sapiens) |
PF00554(RHD_DNA_bind)PF16179(RHD_dimer) | 4 | TYR P 166PRO P 234LEU P 45THR P 127 | None | 1.36A | 1i2wA-1svcP:undetectable | 1i2wA-1svcP:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1thg | LIPASE 2 (Galactomycescandidus) |
PF00135(COesterase) | 4 | TYR A 273PRO A 168LEU A 172THR A 278 | None | 1.25A | 1i2wA-1thgA:undetectable | 1i2wA-1thgA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uek | 4-(CYTIDINE5'-DIPHOSPHO)-2C-METHYL-D-ERYTHRITOLKINASE (Thermusthermophilus) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 4 | TYR A 169PRO A 205LEU A 209ARG A 162 | None | 1.39A | 1i2wA-1uekA:undetectable | 1i2wA-1uekA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vav | ALGINATE LYASEPA1167 (Pseudomonasaeruginosa) |
PF08787(Alginate_lyase2) | 4 | TYR A 193LEU A 218THR A 10ARG A 59 | None | 1.40A | 1i2wA-1vavA:undetectable | 1i2wA-1vavA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w45 | ANNEXIN A8 (Homo sapiens) |
PF00191(Annexin) | 4 | TYR A 257LEU A 288THR A 275ARG A 278 | None | 1.21A | 1i2wA-1w45A:undetectable | 1i2wA-1w45A:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wa5 | IMPORTIN ALPHASUBUNIT (Saccharomycescerevisiae) |
PF00514(Arm)PF01749(IBB)PF16186(Arm_3) | 4 | TYR B 283PRO B 250LEU B 212THR B 236 | None | 1.33A | 1i2wA-1wa5B:undetectable | 1i2wA-1wa5B:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yii | ANNEXIN A5 (Gallus gallus) |
PF00191(Annexin) | 4 | TYR A 250LEU A 281THR A 268ARG A 271 | None | 1.15A | 1i2wA-1yiiA:undetectable | 1i2wA-1yiiA:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yzw | GFP-LIKENON-FLUORESCENTCHROMOPROTEIN (Heteractiscrispa) |
PF01353(GFP) | 4 | PRO A 150LEU A 155THR A 145ARG A 219 | None | 0.98A | 1i2wA-1yzwA:undetectable | 1i2wA-1yzwA:22.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zg4 | BETA-LACTAMASE TEM (Escherichiacoli) |
PF13354(Beta-lactamase2) | 4 | TYR A 105PRO A 167LEU A 169ARG A 244 | None | 0.53A | 1i2wA-1zg4A:37.5 | 1i2wA-1zg4A:37.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zx5 | MANNOSEPHOSPHATEISOMERASE, PUTATIVE (Archaeoglobusfulgidus) |
PF01238(PMI_typeI) | 4 | TYR A 257LEU A 251THR A 265ARG A 261 | None | 1.27A | 1i2wA-1zx5A:undetectable | 1i2wA-1zx5A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abk | ENDONUCLEASE III (Escherichiacoli) |
PF00633(HHH)PF00730(HhH-GPD)PF10576(EndIII_4Fe-2S) | 4 | PRO A 29LEU A 32THR A 134ARG A 108 | None | 1.25A | 1i2wA-2abkA:undetectable | 1i2wA-2abkA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1f | THREONINE SYNTHASE (Mycobacteriumtuberculosis) |
PF00291(PALP) | 4 | TYR A 204PRO A 188LEU A 184THR A 39 | None | 1.34A | 1i2wA-2d1fA:undetectable | 1i2wA-2d1fA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3z | BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF00232(Glyco_hydro_1) | 4 | TYR A 301LEU A 350THR A 227ARG A 77 | None | 1.39A | 1i2wA-2e3zA:undetectable | 1i2wA-2e3zA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gd2 | PROBABLEALPHA-METHYLACYL-COARACEMASE MCR (Mycobacteriumtuberculosis) |
PF02515(CoA_transf_3) | 4 | TYR A 224PRO A 222LEU A 275THR A 299 | None | 1.11A | 1i2wA-2gd2A:undetectable | 1i2wA-2gd2A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8q | RED FLUORESCENTPROTEIN DRFP583 (Discosoma sp.) |
PF01353(GFP) | 4 | PRO A 152LEU A 157THR A 147ARG A 220 | None | 0.90A | 1i2wA-2h8qA:undetectable | 1i2wA-2h8qA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjq | UNCHARACTERIZED RNAMETHYLTRANSFERASEPYRAB10780 (Pyrococcusabyssi) |
PF05958(tRNA_U5-meth_tr) | 4 | TYR A 278LEU A 404THR A 371ARG A 374 | SAH A1406 (-4.7A)NoneNoneNone | 1.20A | 1i2wA-2jjqA:undetectable | 1i2wA-2jjqA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ktq | PROTEIN (LARGEFRAGMENT OF DNAPOLYMERASE I) (Thermusaquaticus) |
PF00476(DNA_pol_A)PF09281(Taq-exonuc) | 4 | TYR A 671LEU A 622THR A 571ARG A 728 | DCT A 113 (-4.7A)NoneNoneNone | 1.31A | 1i2wA-2ktqA:undetectable | 1i2wA-2ktqA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5r | GLUTAMYL-TRNASYNTHETASE 1 (Thermotogamaritima) |
PF00749(tRNA-synt_1c) | 4 | TYR A 268PRO A 270LEU A 63THR A 258 | None | 1.31A | 1i2wA-2o5rA:undetectable | 1i2wA-2o5rA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogf | HYPOTHETICAL PROTEINMJ0408 (Methanocaldococcusjannaschii) |
PF04038(DHNA) | 4 | TYR A 45PRO A 41LEU A 81ARG A 52 | None | 1.35A | 1i2wA-2ogfA:undetectable | 1i2wA-2ogfA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ov1 | PERIPLASMIC BINDINGPROTEIN COMPONENT OFAN ABC TYPE ZINCUPTAKE TRANSPORTER (Synechocystissp. PCC 6803) |
PF01297(ZnuA) | 4 | TYR A 85PRO A 111LEU A 113THR A 52 | None | 1.32A | 1i2wA-2ov1A:undetectable | 1i2wA-2ov1A:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyt | 2-DEHYDROPANTOATE2-REDUCTASE (Porphyromonasgingivalis) |
PF02558(ApbA)PF08546(ApbA_C) | 4 | TYR A 20LEU A 55THR A 59ARG A 62 | NoneNoneNoneEDO A 323 (-3.9A) | 1.33A | 1i2wA-2qytA:undetectable | 1i2wA-2qytA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ran | ANNEXIN V (Rattusnorvegicus) |
PF00191(Annexin) | 4 | TYR A 248LEU A 279THR A 266ARG A 269 | None | 1.13A | 1i2wA-2ranA:undetectable | 1i2wA-2ranA:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vad | RED FLUORESCENTPROTEIN (Discosoma sp.) |
PF01353(GFP) | 4 | PRO A 152LEU A 157THR A 147ARG A 220 | None CL A1227 (-4.9A)NoneNone | 0.92A | 1i2wA-2vadA:undetectable | 1i2wA-2vadA:20.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wyx | BETA-LACTAMSE TOHO-1 (Escherichiacoli) |
PF13354(Beta-lactamase2) | 4 | TYR A 105PRO A 167LEU A 169THR A 235 | None | 0.61A | 1i2wA-2wyxA:40.9 | 1i2wA-2wyxA:41.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsj | THREONINE SYNTHASE (Aquifexaeolicus) |
PF00291(PALP) | 4 | TYR A 197PRO A 181LEU A 177THR A 31 | None | 1.34A | 1i2wA-2zsjA:undetectable | 1i2wA-2zsjA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3act | CELLOBIOSEPHOSPHORYLASE (Cellulomonasgilvus) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | TYR A 103PRO A 122LEU A 123THR A 316 | None | 1.15A | 1i2wA-3actA:undetectable | 1i2wA-3actA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bbj | PUTATIVETHIOESTERASE II (Thermobifidafusca) |
PF13622(4HBT_3) | 4 | PRO A 72LEU A 25THR A 99ARG A 66 | NoneNoneNoneSO4 A 272 (-4.2A) | 1.24A | 1i2wA-3bbjA:undetectable | 1i2wA-3bbjA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3brn | LIPOCALIN (Argasmonolakensis) |
PF02098(His_binding) | 4 | TYR A 152PRO A 155LEU A 156ARG A 30 | None | 1.30A | 1i2wA-3brnA:undetectable | 1i2wA-3brnA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxa | FAR-RED FLUORESCENTPROTEIN MKATE (Entacmaeaquadricolor) |
PF01353(GFP) | 4 | PRO A 149LEU A 154THR A 144ARG A 220 | None | 1.07A | 1i2wA-3bxaA:undetectable | 1i2wA-3bxaA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgl | GFP-LIKE FLUORESCENTCHROMOPROTEINDSFP483 (Discosomastriata) |
PF01353(GFP) | 4 | PRO A 152LEU A 157THR A 147ARG A 221 | None | 0.97A | 1i2wA-3cglA:undetectable | 1i2wA-3cglA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ff4 | UNCHARACTERIZEDPROTEIN (Cytophagahutchinsonii) |
PF13380(CoA_binding_2) | 4 | TYR A 62LEU A 94THR A 58ARG A 82 | None | 1.23A | 1i2wA-3ff4A:undetectable | 1i2wA-3ff4A:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gxo | MMCR (Streptomyceslavendulae) |
PF00891(Methyltransf_2) | 4 | PRO A 44LEU A 47THR A 55ARG A 69 | None | 1.33A | 1i2wA-3gxoA:undetectable | 1i2wA-3gxoA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4x | TRYPTOPHANDIMETHYLALLYLTRANSFERASE (Aspergillusfumigatus) |
PF11991(Trp_DMAT) | 4 | TYR A 310PRO A 313LEU A 315THR A 347 | NoneNoneGOL A 462 ( 4.4A)None | 1.36A | 1i2wA-3i4xA:undetectable | 1i2wA-3i4xA:23.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lez | BETA-LACTAMASE (Oceanobacillusiheyensis) |
PF13354(Beta-lactamase2) | 4 | TYR A 118LEU A 182THR A 248ARG A 256 | EPE A 305 (-3.3A)NoneEPE A 305 (-3.6A)EPE A 305 (-3.7A) | 0.34A | 1i2wA-3lezA:44.1 | 1i2wA-3lezA:55.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nqh | GLYCOSYL HYDROLASE (Bacteroidesthetaiotaomicron) |
PF04616(Glyco_hydro_43) | 4 | TYR A 404PRO A 287THR A 226ARG A 443 | None | 1.26A | 1i2wA-3nqhA:undetectable | 1i2wA-3nqhA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntl | ACIDGLUCOSE-1-PHOSPHATEPHOSPHATASE (Enterobactercloacae) |
PF00328(His_Phos_2) | 4 | TYR A 216PRO A 21LEU A 22THR A 312 | NoneNoneIHP A 550 (-3.7A)None | 1.31A | 1i2wA-3ntlA:undetectable | 1i2wA-3ntlA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o6q | STAGE II SPORULATIONPROTEIN SA (Bacillussubtilis) |
PF14171(SpoIISA_toxin) | 4 | TYR A 211LEU A 186THR A 165ARG A 171 | None | 1.36A | 1i2wA-3o6qA:undetectable | 1i2wA-3o6qA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pop | GILR OXIDASE (Streptomycesgriseoflavus) |
PF01565(FAD_binding_4)PF08031(BBE) | 4 | PRO A 231LEU A 278THR A 242ARG A 246 | None | 0.90A | 1i2wA-3popA:undetectable | 1i2wA-3popA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qdk | RIBULOKINASE (Bacillushalodurans) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | TYR A 177PRO A 101LEU A 184THR A 235 | None | 1.26A | 1i2wA-3qdkA:undetectable | 1i2wA-3qdkA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwa | FLUORESCENT PROTEINFP480 (Entacmaeaquadricolor) |
PF01353(GFP) | 4 | PRO A 219LEU A 224THR A 214ARG A 53 | None | 1.29A | 1i2wA-3rwaA:undetectable | 1i2wA-3rwaA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wq4 | BETA-PRIMEVEROSIDASE (Camelliasinensis) |
PF00232(Glyco_hydro_1) | 4 | TYR A 345LEU A 400THR A 271ARG A 111 | None | 1.37A | 1i2wA-3wq4A:undetectable | 1i2wA-3wq4A:19.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zdj | ENCA BETA-LACTAMASE (syntheticconstruct) |
PF13354(Beta-lactamase2) | 4 | TYR A 105LEU A 169THR A 235ARG A 244 | NoneNoneSO4 A1291 (-3.6A)SO4 A1291 ( 3.6A) | 0.38A | 1i2wA-3zdjA:38.1 | 1i2wA-3zdjA:38.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zny | CTX-M-12A ENZYME (Klebsiellapneumoniae) |
PF13354(Beta-lactamase2) | 4 | TYR A 105PRO A 167LEU A 169THR A 235 | None | 0.45A | 1i2wA-3znyA:41.6 | 1i2wA-3znyA:41.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zou | FARNESYLPYROPHOSPHATESYNTHASE (Pseudomonasaeruginosa) |
PF00348(polyprenyl_synt) | 4 | PRO A 201LEU A 204THR A 142ARG A 146 | None | 1.23A | 1i2wA-3zouA:undetectable | 1i2wA-3zouA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2w | RETINOIC ACIDINDUCIBLE PROTEIN I (Anasplatyrhynchos) |
PF00270(DEAD)PF00271(Helicase_C)PF16739(CARD_2) | 4 | TYR A 393LEU A 363THR A 370ARG A 292 | None | 1.27A | 1i2wA-4a2wA:undetectable | 1i2wA-4a2wA:16.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c75 | BETA-LACTAMASE (syntheticconstruct) |
PF13354(Beta-lactamase2) | 5 | TYR A 105PRO A 167LEU A 169THR A 235ARG A 244 | NoneNoneNoneSO4 A 291 (-3.8A)SO4 A 291 (-4.1A) | 0.75A | 1i2wA-4c75A:41.1 | 1i2wA-4c75A:54.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d1i | BETA-GALACTOSIDASE,PUTATIVE, BGL35A (Cellvibriojaponicus) |
PF02449(Glyco_hydro_42) | 4 | PRO A 72LEU A 75THR A 196ARG A 119 | None | 1.34A | 1i2wA-4d1iA:undetectable | 1i2wA-4d1iA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fus | RTX TOXINS ANDRELATED CA2+-BINDINGPROTEIN (Hahellachejuensis) |
PF02011(Glyco_hydro_48) | 4 | TYR A 63PRO A 74LEU A 181THR A 199 | None | 1.36A | 1i2wA-4fusA:undetectable | 1i2wA-4fusA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gbm | CURMSULFOTRANSFERASE (Mooreaproducens) |
PF13469(Sulfotransfer_3) | 4 | TYR A 248LEU A 229THR A 43ARG A 46 | NoneNoneA3P A 406 ( 3.6A)None | 1.20A | 1i2wA-4gbmA:undetectable | 1i2wA-4gbmA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gjp | HAX3 (Xanthomonascampestris) |
PF03377(TAL_effector) | 4 | PRO A 563LEU A 527THR A 547ARG A 550 | None | 1.40A | 1i2wA-4gjpA:undetectable | 1i2wA-4gjpA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gjp | HAX3 (Xanthomonascampestris) |
PF03377(TAL_effector) | 4 | PRO A 665LEU A 629THR A 649ARG A 652 | None | 1.33A | 1i2wA-4gjpA:undetectable | 1i2wA-4gjpA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gox | POLYKETIDE SYNTHASE (Synechococcussp. PCC 7002) |
PF13469(Sulfotransfer_3) | 4 | TYR A 248LEU A 229THR A 43ARG A 46 | A3P A 401 (-4.6A)NoneA3P A 401 (-3.6A)None | 1.36A | 1i2wA-4goxA:undetectable | 1i2wA-4goxA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gri | GLUTAMATE--TRNALIGASE (Borreliellaburgdorferi) |
PF00749(tRNA-synt_1c) | 4 | TYR A 270PRO A 272LEU A 65THR A 260 | None | 1.09A | 1i2wA-4griA:undetectable | 1i2wA-4griA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hjj | ANTI-IL12 ANTI-IL18DFAB LIGHT CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR L 254PRO L 128LEU L 191THR L 123 | None | 1.31A | 1i2wA-4hjjL:undetectable | 1i2wA-4hjjL:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf5 | FLUORESCENT PROTEINSFCHERRY+GFP10-11 (syntheticconstruct) |
PF01353(GFP) | 4 | PRO C 152LEU C 157THR C 147ARG C 260 | None | 0.94A | 1i2wA-4kf5C:undetectable | 1i2wA-4kf5C:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mrp | ABC TRANSPORTERRELATED PROTEIN (Novosphingobiumaromaticivorans) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 4 | TYR A 87LEU A 54THR A 309ARG A 313 | None | 1.27A | 1i2wA-4mrpA:undetectable | 1i2wA-4mrpA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oca | UDP-4-AMINO-4-DEOXY-L-ARABINOSE--OXOGLUTARATEAMINOTRANSFERASE (Salmonellaenterica) |
PF01041(DegT_DnrJ_EryC1) | 4 | TYR A 136PRO A 140LEU A 143THR A 84 | None | 1.38A | 1i2wA-4ocaA:undetectable | 1i2wA-4ocaA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oer | NIKA PROTEIN (Brucella suis) |
PF00496(SBP_bac_5) | 4 | TYR A 32PRO A 34LEU A 35THR A 88 | None | 1.15A | 1i2wA-4oerA:undetectable | 1i2wA-4oerA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pde | PROTEIN FDHD (Escherichiacoli) |
PF02634(FdhD-NarQ) | 4 | TYR A 269PRO A 272LEU A 275ARG A 265 | NoneNoneNoneGDP A 300 (-3.0A) | 1.14A | 1i2wA-4pdeA:undetectable | 1i2wA-4pdeA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rya | ABC TRANSPORTERSUBSTRATE BINDINGPROTEIN (SORBITOL) (Agrobacteriumvitis) |
PF01547(SBP_bac_1) | 4 | TYR A 135PRO A 133LEU A 123ARG A 65 | MTL A 501 (-4.5A)NoneNoneMTL A 501 (-3.1A) | 1.36A | 1i2wA-4ryaA:undetectable | 1i2wA-4ryaA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uek | GALACTITOL-1-PHOSPHATE 5-DEHYDROGENASE (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | PRO A 136LEU A 131THR A 301ARG A 304 | None | 1.23A | 1i2wA-4uekA:undetectable | 1i2wA-4uekA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uxv | SEPTATION RINGFORMATION REGULATOREZRA (Bacillussubtilis) |
PF06160(EzrA) | 4 | TYR A 211PRO A 216LEU A 219THR A 272 | None | 1.36A | 1i2wA-4uxvA:undetectable | 1i2wA-4uxvA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yeb | FIBRONECTIN LEUCINERICH TRANSMEMBRANEPROTEIN 3 (Mus musculus) |
PF13855(LRR_8) | 4 | TYR B 91LEU B 102THR B 62ARG B 87 | None | 1.38A | 1i2wA-4yebB:undetectable | 1i2wA-4yebB:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z81 | EGF FAMILYDOMAIN-CONTAININGPROTEIN (Toxoplasmagondii) |
PF02430(AMA-1)PF07974(EGF_2) | 4 | TYR A 150PRO A 401LEU A 402THR A 394 | None | 1.27A | 1i2wA-4z81A:undetectable | 1i2wA-4z81A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a55 | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 4 | TYR A 393PRO A 379LEU A 397THR A 424 | None | 1.38A | 1i2wA-5a55A:undetectable | 1i2wA-5a55A:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dld | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Burkholderiavietnamiensis) |
PF02350(Epimerase_2) | 4 | PRO A 330LEU A 332THR A 311ARG A 309 | NoneNoneNoneACT A 505 (-4.1A) | 1.35A | 1i2wA-5dldA:undetectable | 1i2wA-5dldA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5do7 | ATP-BINDING CASSETTESUB-FAMILY G MEMBER5 (Homo sapiens) |
PF00005(ABC_tran)PF01061(ABC2_membrane) | 4 | TYR A 628PRO A 632LEU A 634THR A 430 | None | 1.27A | 1i2wA-5do7A:undetectable | 1i2wA-5do7A:18.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e2e | BETA-LACTAMASE (Yersiniaenterocolitica) |
PF13354(Beta-lactamase2) | 4 | TYR A 82PRO A 144LEU A 146THR A 212 | None | 0.58A | 1i2wA-5e2eA:41.6 | 1i2wA-5e2eA:41.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e2e | BETA-LACTAMASE (Yersiniaenterocolitica) |
PF13354(Beta-lactamase2) | 4 | TYR A 82PRO A 144THR A 212ARG A 251 | None | 1.31A | 1i2wA-5e2eA:41.6 | 1i2wA-5e2eA:41.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eoe | BETA-LACTAMASE (Pseudomonasaeruginosa) |
PF13354(Beta-lactamase2) | 4 | TYR A 97PRO A 160LEU A 162THR A 228 | CIT A 303 (-4.1A)NoneNoneCIT A 303 (-3.6A) | 0.55A | 1i2wA-5eoeA:39.1 | 1i2wA-5eoeA:37.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3h | ABHYDROLASEDOMAIN-CONTAININGPROTEIN (Exiguobacteriumantarcticum) |
PF00561(Abhydrolase_1)PF08386(Abhydrolase_4) | 4 | TYR A 71LEU A 205THR A 128ARG A 130 | None | 1.27A | 1i2wA-5h3hA:undetectable | 1i2wA-5h3hA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i5d | INNER MEMBRANEPROTEIN YEJM (Salmonellaenterica) |
PF00884(Sulfatase)PF11893(DUF3413) | 4 | PRO A 280LEU A 282THR A 293ARG A 484 | None | 1.21A | 1i2wA-5i5dA:undetectable | 1i2wA-5i5dA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lk4 | MSCARLET (Discosoma sp.) |
PF01353(GFP) | 4 | PRO A 153LEU A 158THR A 148ARG A 221 | NoneNonePGE A 306 (-4.7A)PO4 A 302 (-3.1A) | 1.07A | 1i2wA-5lk4A:undetectable | 1i2wA-5lk4A:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mjv | CAPSID SUBUNIT VP0 (Parechovirus A) |
PF00073(Rhv) | 4 | TYR C 154PRO C 115LEU C 272ARG C 278 | None | 1.20A | 1i2wA-5mjvC:undetectable | 1i2wA-5mjvC:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mtz | RIBONUCLEASE Z (Saccharomycescerevisiae) |
PF13691(Lactamase_B_4) | 4 | TYR A 347PRO A 350THR A 473ARG A 482 | None | 1.30A | 1i2wA-5mtzA:undetectable | 1i2wA-5mtzA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oyp | STRUCTURAL PROTEINVP2 (Sacbrood virus) |
no annotation | 4 | TYR B 83PRO B 85LEU B 112ARG B 152 | None | 1.22A | 1i2wA-5oypB:undetectable | 1i2wA-5oypB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vqi | IMPORTIN SUBUNITALPHA (Neurosporacrassa) |
no annotation | 4 | TYR B 277PRO B 244LEU B 205THR B 230 | None | 1.33A | 1i2wA-5vqiB:undetectable | 1i2wA-5vqiB:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wka | BETA-GLUCOSIDASE (metagenome) |
no annotation | 4 | TYR A 292LEU A 353THR A 215ARG A 73 | GOL A 501 (-4.3A)NoneNoneNone | 1.22A | 1i2wA-5wkaA:undetectable | 1i2wA-5wkaA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wka | BETA-GLUCOSIDASE (metagenome) |
no annotation | 4 | TYR A 292PRO A 294LEU A 221THR A 164 | GOL A 501 (-4.3A)NoneNoneNone | 1.38A | 1i2wA-5wkaA:undetectable | 1i2wA-5wkaA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wmm | NRPS (Micromonosporasp. ML1) |
no annotation | 4 | TYR A 217LEU A 285THR A 301ARG A 319 | NoneNoneNone CA A1006 (-4.0A) | 1.30A | 1i2wA-5wmmA:undetectable | 1i2wA-5wmmA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wyb | PROBABLE ENOYL-COAHYDRATASE/ISOMERASE (Pseudomonasaeruginosa) |
no annotation | 4 | PRO B 162LEU B 164THR B 184ARG B 187 | None | 1.10A | 1i2wA-5wybB:undetectable | 1i2wA-5wybB:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xya | - (-) |
no annotation | 4 | TYR A1106LEU A1101THR A1027ARG A1034 | None | 1.16A | 1i2wA-5xyaA:undetectable | 1i2wA-5xyaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bu3 | BETA-LACTAMASE (Escherichiacoli) |
no annotation | 4 | TYR A 105PRO A 167LEU A 169THR A 235 | 3GK A 302 ( 3.5A)3GK A 301 (-4.1A)None3GK A 301 (-3.7A) | 0.39A | 1i2wA-6bu3A:41.6 | 1i2wA-6bu3A:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d5i | PHOSPHOENOLPYRUVATECARBOXYKINASE (ATP) (Escherichiacoli) |
no annotation | 4 | PRO A 403LEU A 513THR A 441ARG A 449 | NoneNoneATP A 601 ( 4.1A)ATP A 601 (-3.1A) | 1.31A | 1i2wA-6d5iA:undetectable | 1i2wA-6d5iA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eh1 | STRUCTURAL PROTEINVP2 (Sacbrood virus) |
no annotation | 4 | TYR B 83PRO B 85LEU B 112ARG B 152 | None | 1.23A | 1i2wA-6eh1B:undetectable | 1i2wA-6eh1B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6erc | PEROXINECTIN A (Dictyosteliumdiscoideum) |
no annotation | 4 | PRO A 414LEU A 418THR A 317ARG A 322 | NoneNoneHEM A 604 (-3.3A)HEM A 604 (-2.4A) | 1.13A | 1i2wA-6ercA:undetectable | 1i2wA-6ercA:18.10 |