SIMILAR PATTERNS OF AMINO ACIDS FOR 1HZE_B_RBFB99_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		5 THR A 122
ILE A   5
LEU A 112
LEU A 108
ILE A  33
 None
 1.45A 1hzeA-1ezrA:
0.0
1hzeB-1ezrA:
0.0		 1hzeA-1ezrA:
17.89
1hzeB-1ezrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		5 THR A 122
ILE A   5
LEU A 112
LEU A 108
THR A  34
 None
 1.45A 1hzeA-1ezrA:
0.0
1hzeB-1ezrA:
0.0		 1hzeA-1ezrA:
17.89
1hzeB-1ezrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 THR B 808
ILE B 807
LEU B 780
THR B 794
ILE B 797
 None
 1.39A 1hzeA-1gl9B:
0.0
1hzeB-1gl9B:
0.0		 1hzeA-1gl9B:
6.74
1hzeB-1gl9B:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i31 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 THR A 433
ILE A 386
CYH A 435
LEU A 301
ILE A 351
 None
 1.38A 1hzeA-1i31A:
0.0
1hzeB-1i31A:
undetectable		 1hzeA-1i31A:
12.94
1hzeB-1i31A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3g CYTOCHROME C-553

(Sporosarcina
pasteurii) 		PF13442
(Cytochrome_CBB3) 		5 ILE A  48
LEU A  61
ASP A  62
LEU A  65
ILE A  75
 HEC  A  93 (-3.8A)
None
None
None
HEC  A  93 (-3.5A)
 1.46A 1hzeA-1k3gA:
undetectable
1hzeB-1k3gA:
undetectable		 1hzeA-1k3gA:
21.21
1hzeB-1k3gA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 156
ILE A  26
LEU A  33
LEU A 118
ILE A 126
 FAD  A 499 (-3.9A)
None
NIY  A 114 ( 4.1A)
NIY  A 114 ( 3.9A)
None
 1.38A 1hzeA-1k4qA:
0.0
1hzeB-1k4qA:
0.0		 1hzeA-1k4qA:
13.43
1hzeB-1k4qA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		5 ILE A 286
LEU A 257
LEU A 253
THR A 292
ILE A 291
 None
 1.27A 1hzeA-1oedA:
undetectable
1hzeB-1oedA:
undetectable		 1hzeA-1oedA:
17.27
1hzeB-1oedA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster) 		PF00106
(adh_short) 		5 THR A   8
CYH A  10
LEU A  16
THR A 220
ILE A 223
 None
 1.36A 1hzeA-1snyA:
0.0
1hzeB-1snyA:
0.0		 1hzeA-1snyA:
15.18
1hzeB-1snyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster) 		PF00106
(adh_short) 		5 THR A  34
ILE A   7
LEU A  84
LEU A 130
ILE A 150
 None
 1.31A 1hzeA-1snyA:
0.0
1hzeB-1snyA:
0.0		 1hzeA-1snyA:
15.18
1hzeB-1snyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG

(Homo sapiens) 		PF03657
(UPF0113) 		5 THR A 150
ILE A 121
CYH A 153
LEU A 114
ILE A  99
 None
 1.27A 1hzeA-1sqwA:
0.0
1hzeB-1sqwA:
0.0		 1hzeA-1sqwA:
20.42
1hzeB-1sqwA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 THR A  83
ILE A  96
LEU A  90
ASP A 246
ILE A 602
 None
 1.41A 1hzeA-2h88A:
0.0
1hzeB-2h88A:
0.0		 1hzeA-2h88A:
9.50
1hzeB-2h88A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 THR A  36
ILE A  37
ASP A 206
LEU A 207
ILE A  44
 None
 1.04A 1hzeA-2hivA:
0.0
1hzeB-2hivA:
0.0		 1hzeA-2hivA:
11.21
1hzeB-2hivA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Porphyromonas
gingivalis) 		PF00588
(SpoU_methylase) 		5 ILE A 126
CYH A 247
LEU A 246
LEU A 221
ILE A 199
 None
 1.39A 1hzeA-2i6dA:
undetectable
1hzeB-2i6dA:
undetectable		 1hzeA-2i6dA:
17.39
1hzeB-2i6dA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN

(Homo sapiens) 		PF11510
(FA_FANCE) 		5 THR A 395
LEU A 403
ASP A 404
LEU A 407
ILE A 372
 None
 1.37A 1hzeA-2ilrA:
undetectable
1hzeB-2ilrA:
undetectable		 1hzeA-2ilrA:
15.74
1hzeB-2ilrA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		5 THR A 122
ILE A   5
LEU A 112
LEU A 108
ILE A  33
 None
 1.45A 1hzeA-2masA:
undetectable
1hzeB-2masA:
undetectable		 1hzeA-2masA:
16.29
1hzeB-2masA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		5 THR A 122
ILE A   5
LEU A 112
LEU A 108
THR A  34
 None
 1.46A 1hzeA-2masA:
undetectable
1hzeB-2masA:
undetectable		 1hzeA-2masA:
16.29
1hzeB-2masA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppq HOMOSERINE KINASE

(Agrobacterium
fabrum) 		PF01636
(APH) 		5 THR A  51
ILE A  49
LEU A  12
LEU A  24
THR A  43
 None
 1.44A 1hzeA-2ppqA:
undetectable
1hzeB-2ppqA:
undetectable		 1hzeA-2ppqA:
15.08
1hzeB-2ppqA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7x UPF0052 PROTEIN
SP_1565

(Streptococcus
pneumoniae) 		PF01933
(UPF0052) 		5 THR A   7
ILE A 187
LEU A 317
LEU A 256
ILE A 252
 None
 1.39A 1hzeA-2q7xA:
undetectable
1hzeB-2q7xA:
undetectable		 1hzeA-2q7xA:
17.21
1hzeB-2q7xA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		5 THR A 247
ILE A 216
LEU A 198
ASP A 199
ILE A 137
 None
 1.40A 1hzeA-2qv6A:
undetectable
1hzeB-2qv6A:
undetectable		 1hzeA-2qv6A:
17.36
1hzeB-2qv6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzi UNCHARACTERIZED
PROTEIN

(Streptococcus
thermophilus) 		PF08860
(DUF1827) 		5 THR A  85
ILE A  94
ASP A  81
LEU A  79
ILE A  73
 None
 1.43A 1hzeA-2qziA:
undetectable
1hzeB-2qziA:
undetectable		 1hzeA-2qziA:
21.49
1hzeB-2qziA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 THR A 306
ILE A 310
LEU A 319
LEU A 401
THR A 315
 None
 1.27A 1hzeA-2rkoA:
undetectable
1hzeB-2rkoA:
undetectable		 1hzeA-2rkoA:
15.41
1hzeB-2rkoA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT

(Arabidopsis
thaliana) 		PF00503
(G-alpha) 		5 THR A 132
ILE A 135
LEU A 174
LEU A 167
ILE A  86
 None
 1.18A 1hzeA-2xtzA:
undetectable
1hzeB-2xtzA:
undetectable		 1hzeA-2xtzA:
14.08
1hzeB-2xtzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		5 THR A 191
ILE A 207
LEU A 180
LEU A 153
ILE A 128
 None
 1.36A 1hzeA-2xyqA:
undetectable
1hzeB-2xyqA:
undetectable		 1hzeA-2xyqA:
14.81
1hzeB-2xyqA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		5 THR A  50
ILE A  49
LEU A  99
ASP A 120
LEU A 116
 None
 1.44A 1hzeA-2z55A:
undetectable
1hzeB-2z55A:
undetectable		 1hzeA-2z55A:
20.00
1hzeB-2z55A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8i PA4872 OXALOACETATE
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF13714
(PEP_mutase) 		5 THR A  25
ILE A  46
CYH A  44
LEU A   9
ILE A 111
 None
 1.16A 1hzeA-3b8iA:
undetectable
1hzeB-3b8iA:
undetectable		 1hzeA-3b8iA:
17.07
1hzeB-3b8iA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN

(Bacteroides
fragilis) 		PF12985
(DUF3869) 		5 THR A 285
LEU A 184
ASP A 185
LEU A 188
ILE A 221
 None
 1.27A 1hzeA-3g3lA:
undetectable
1hzeB-3g3lA:
undetectable		 1hzeA-3g3lA:
16.34
1hzeB-3g3lA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 THR A1665
LEU A1440
LEU A1749
THR A1745
ILE A1744
 None
 1.46A 1hzeA-3ig3A:
undetectable
1hzeB-3ig3A:
undetectable		 1hzeA-3ig3A:
9.66
1hzeB-3ig3A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l43 DYNAMIN-3

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 THR A 200
ILE A 171
LEU A 281
LEU A 132
ILE A 135
 None
 1.21A 1hzeA-3l43A:
undetectable
1hzeB-3l43A:
undetectable		 1hzeA-3l43A:
16.40
1hzeB-3l43A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00579
(tRNA-synt_1b) 		5 THR A 137
ILE A 132
LEU A 170
LEU A 158
ILE A 152
 None
 1.44A 1hzeA-3m5wA:
undetectable
1hzeB-3m5wA:
undetectable		 1hzeA-3m5wA:
19.74
1hzeB-3m5wA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		5 THR A 466
ILE A 414
LEU A 386
LEU A 316
ILE A 416
 None
 1.21A 1hzeA-3m99A:
undetectable
1hzeB-3m99A:
undetectable		 1hzeA-3m99A:
11.36
1hzeB-3m99A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu8 AMINOTRANSFERASE
WBPE

(Pseudomonas
aeruginosa) 		PF01041
(DegT_DnrJ_EryC1) 		5 ILE A 350
CYH A 354
LEU A 357
LEU A 298
ILE A   2
 None
 1.46A 1hzeA-3nu8A:
undetectable
1hzeB-3nu8A:
undetectable		 1hzeA-3nu8A:
13.48
1hzeB-3nu8A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3d NUCLEOPORIN 53

(Meyerozyma
guilliermondii) 		PF05172
(Nup35_RRM) 		5 ILE A 282
LEU A 292
ASP A 328
ILE A 268
LYS A 300
 None
 1.27A 1hzeA-3p3dA:
undetectable
1hzeB-3p3dA:
undetectable		 1hzeA-3p3dA:
24.24
1hzeB-3p3dA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r24 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		5 THR A 191
ILE A 207
LEU A 180
LEU A 153
ILE A 128
 None
 1.37A 1hzeA-3r24A:
undetectable
1hzeB-3r24A:
undetectable		 1hzeA-3r24A:
14.24
1hzeB-3r24A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		5 ILE A 302
CYH A 284
LEU A 207
LEU A 193
ILE A 199
 None
 1.34A 1hzeA-3r7wA:
undetectable
1hzeB-3r7wA:
undetectable		 1hzeA-3r7wA:
15.72
1hzeB-3r7wA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A   5
LEU A  21
LEU A 332
THR A 334
ILE A  92
 None
 1.40A 1hzeA-3tz6A:
undetectable
1hzeB-3tz6A:
undetectable		 1hzeA-3tz6A:
16.56
1hzeB-3tz6A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A   7
LEU A  21
LEU A 332
THR A 334
ILE A  92
 None
 1.50A 1hzeA-3tz6A:
undetectable
1hzeB-3tz6A:
undetectable		 1hzeA-3tz6A:
16.56
1hzeB-3tz6A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		5 THR A  10
ILE A  11
LEU A 115
LEU A 121
ILE A 193
 None
 1.35A 1hzeA-4ckbA:
undetectable
1hzeB-4ckbA:
undetectable		 1hzeA-4ckbA:
8.32
1hzeB-4ckbA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4o HAPTOGLOBIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 THR C 161
ILE C 158
LEU C 164
LEU C 138
THR C 140
 None
 1.40A 1hzeA-4f4oC:
1.2
1hzeB-4f4oC:
1.1		 1hzeA-4f4oC:
13.37
1hzeB-4f4oC:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ILE A 211
LEU A 144
LEU A 142
THR A 255
ILE A 218
 P6G  A 305 ( 4.9A)
None
None
None
None
 1.27A 1hzeA-4h16A:
undetectable
1hzeB-4h16A:
undetectable		 1hzeA-4h16A:
17.51
1hzeB-4h16A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		5 THR A 205
ILE A 209
LEU A 168
THR A 215
ILE A 216
 None
 1.22A 1hzeA-4i2wA:
undetectable
1hzeB-4i2wA:
undetectable		 1hzeA-4i2wA:
7.63
1hzeB-4i2wA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		5 THR A 429
ILE A 431
LEU A 443
LEU A 255
ILE A 370
 None
 1.45A 1hzeA-4issA:
undetectable
1hzeB-4issA:
undetectable		 1hzeA-4issA:
9.45
1hzeB-4issA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		5 THR A 391
ILE A 390
LEU A 327
ASP A 331
ILE A 346
 None
 1.19A 1hzeA-4l4qA:
undetectable
1hzeB-4l4qA:
undetectable		 1hzeA-4l4qA:
12.10
1hzeB-4l4qA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 ILE A 341
LEU A 311
ASP A 310
LEU A 309
ILE A 353
 None
 1.28A 1hzeA-4om9A:
2.4
1hzeB-4om9A:
2.2		 1hzeA-4om9A:
6.89
1hzeB-4om9A:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 ILE A 214
LEU A 239
ASP A 270
LEU A 271
ILE A 253
 None
 1.38A 1hzeA-4perA:
undetectable
1hzeB-4perA:
undetectable		 1hzeA-4perA:
11.96
1hzeB-4perA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 ILE A  97
LEU A 361
ASP A 358
LEU A 357
THR A  91
 None
 1.48A 1hzeA-4pf1A:
undetectable
1hzeB-4pf1A:
undetectable		 1hzeA-4pf1A:
10.16
1hzeB-4pf1A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqu ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 374
LEU A  46
ASP A  50
THR A 148
ILE A  41
 None
 1.49A 1hzeA-4rquA:
undetectable
1hzeB-4rquA:
undetectable		 1hzeA-4rquA:
14.89
1hzeB-4rquA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens) 		no annotation 5 THR C 216
ILE C 213
LEU C 219
LEU C 193
THR C 195
 None
 1.45A 1hzeA-4wjgC:
1.1
1hzeB-4wjgC:
1.1		 1hzeA-4wjgC:
14.60
1hzeB-4wjgC:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		5 ILE A 241
LEU A 235
ASP A 234
LEU A 231
ILE A 219
 None
 1.44A 1hzeA-4x4wA:
undetectable
1hzeB-4x4wA:
undetectable		 1hzeA-4x4wA:
13.94
1hzeB-4x4wA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgn 3-HYDROXYACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00106
(adh_short) 		5 THR A 115
ILE A 119
LEU A   9
LEU A  77
ILE A 181
 None
 1.38A 1hzeA-4xgnA:
undetectable
1hzeB-4xgnA:
undetectable		 1hzeA-4xgnA:
17.58
1hzeB-4xgnA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6s EPOXYQUEUOSINE
REDUCTASE

(Streptococcus
thermophilus) 		PF08331
(DUF1730)
PF13484
(Fer4_16) 		5 THR A 325
ILE A 316
LEU A 268
LEU A 265
ILE A 309
 None
 1.30A 1hzeA-5d6sA:
undetectable
1hzeB-5d6sA:
undetectable		 1hzeA-5d6sA:
15.06
1hzeB-5d6sA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A 429
ILE A 431
LEU A 443
LEU A 255
ILE A 370
 None
 1.43A 1hzeA-5i8iA:
undetectable
1hzeB-5i8iA:
undetectable		 1hzeA-5i8iA:
4.55
1hzeB-5i8iA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz3 PREDICTED PROTEIN

(Physcomitrella
patens) 		PF00316
(FBPase) 		5 THR B 253
ILE B 304
LEU B 240
THR B 225
ILE B 219
 None
 1.40A 1hzeA-5iz3B:
undetectable
1hzeB-5iz3B:
undetectable		 1hzeA-5iz3B:
20.00
1hzeB-5iz3B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpq ES7

(Chaetomium
thermophilum) 		PF01798
(Nop) 		5 ILE s  63
LEU s  37
LEU s  33
ILE s  81
LYS s   2
 None
 1.45A 1hzeA-5jpqs:
undetectable
1hzeB-5jpqs:
undetectable		 1hzeA-5jpqs:
19.80
1hzeB-5jpqs:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 5 ILE H 103
LEU H  21
LEU H  91
ILE H  44
LYS H 231
 None
 1.34A 1hzeA-5jrpH:
undetectable
1hzeB-5jrpH:
undetectable		 1hzeA-5jrpH:
18.33
1hzeB-5jrpH:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF03279
(Lip_A_acyltrans) 		5 THR B 140
ILE B 177
LEU B 118
LEU B 227
ILE B 219
 None
 1.48A 1hzeA-5kn7B:
undetectable
1hzeB-5kn7B:
undetectable		 1hzeA-5kn7B:
17.47
1hzeB-5kn7B:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kom PUTATIVE FLUORIDE
ION TRANSPORTER CRCB

(Escherichia
coli) 		PF02537
(CRCB) 		5 THR A  70
ILE A  69
CYH A  74
LEU A  77
LEU A  18
 None
 1.40A 1hzeA-5komA:
undetectable
1hzeB-5komA:
undetectable		 1hzeA-5komA:
25.66
1hzeB-5komA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2)
PF00499
(Oxidored_q3)
PF06444
(NADH_dehy_S2_C) 		5 ILE J 171
LEU K  78
ASP K  88
LEU K  26
THR N  57
 None
 1.41A 1hzeA-5lc5J:
undetectable
1hzeB-5lc5J:
undetectable		 1hzeA-5lc5J:
21.21
1hzeB-5lc5J:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mi0 RETICULOCYTE
BINDING-LIKE PROTEIN
5,RETICULOCYTE
BINDING PROTEIN 5

(Plasmodium
falciparum) 		no annotation 5 THR A 428
LEU A 475
ASP A 162
LEU A 164
THR A 482
 None
 1.45A 1hzeA-5mi0A:
undetectable
1hzeB-5mi0A:
undetectable		 1hzeA-5mi0A:
12.91
1hzeB-5mi0A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 THR A 338
ILE A 375
ASP A 131
THR A  89
ILE A  88
 None
 1.40A 1hzeA-5ngkA:
undetectable
1hzeB-5ngkA:
undetectable		 1hzeA-5ngkA:
10.77
1hzeB-5ngkA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owg PCYX_EBK42635

(marine
metagenome) 		no annotation 5 ILE A  82
CYH A  71
LEU A  70
LEU A 165
ILE A 172
 None
 1.46A 1hzeA-5owgA:
undetectable
1hzeB-5owgA:
undetectable		 1hzeA-5owgA:
14.75
1hzeB-5owgA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsq IUNH

(Leishmania
braziliensis) 		PF01156
(IU_nuc_hydro) 		5 THR A 122
ILE A   5
LEU A 112
LEU A 108
ILE A  33
 None
 1.46A 1hzeA-5tsqA:
undetectable
1hzeB-5tsqA:
undetectable		 1hzeA-5tsqA:
17.63
1hzeB-5tsqA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsq IUNH

(Leishmania
braziliensis) 		PF01156
(IU_nuc_hydro) 		5 THR A 122
ILE A   5
LEU A 112
LEU A 108
THR A  34
 None
 1.47A 1hzeA-5tsqA:
undetectable
1hzeB-5tsqA:
undetectable		 1hzeA-5tsqA:
17.63
1hzeB-5tsqA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION
CONTROL PROTEIN 6

(Saccharomyces
cerevisiae) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 THR 9 420
ILE 9 417
ASP 9 487
THR 9 463
ILE 9 464
 None
 1.27A 1hzeA-5udb9:
undetectable
1hzeB-5udb9:
undetectable		 1hzeA-5udb9:
11.11
1hzeB-5udb9:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila) 		no annotation 5 THR A 109
ILE A  34
ASP A 180
LEU A 181
ILE A  73
 None
None
CTR  A 505 (-3.8A)
None
PCA  A   1 ( 4.8A)
 1.46A 1hzeA-5w11A:
undetectable
1hzeB-5w11A:
undetectable		 1hzeA-5w11A:
21.18
1hzeB-5w11A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi4 DYNEIN LIGHT CHAIN
TCTEX-TYPE 1,RHO
GUANINE NUCLEOTIDE
EXCHANGE FACTOR 2

(Mus musculus) 		no annotation 5 ILE A  25
CYH A  67
LEU A  47
LEU A  51
ILE A  20
 None
 1.44A 1hzeA-5wi4A:
undetectable
1hzeB-5wi4A:
undetectable		 1hzeA-5wi4A:
22.60
1hzeB-5wi4A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx4 FLUORIDE ION
TRANSPORTER CRCB

(Escherichia
coli) 		no annotation 5 THR A  70
ILE A  69
CYH A  74
LEU A  77
LEU A  18
 None
 1.47A 1hzeA-6bx4A:
undetectable
1hzeB-6bx4A:
undetectable		 1hzeA-6bx4A:
26.92
1hzeB-6bx4A:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f7s SERRATE RNA EFFECTOR
MOLECULE
HOMOLOG,SERRATE RNA
EFFECTOR MOLECULE
HOMOLOG

(Homo sapiens) 		no annotation 5 ILE C 506
LEU C 612
ASP C 609
LEU C 608
ILE C 515
 None
 1.30A 1hzeA-6f7sC:
undetectable
1hzeB-6f7sC:
undetectable		 1hzeA-6f7sC:
16.33
1hzeB-6f7sC:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 5 THR D 422
ILE D 418
CYH D 426
LEU D 476
ILE D 392
 None
 1.35A 1hzeA-6gsaD:
undetectable
1hzeB-6gsaD:
undetectable		 1hzeA-6gsaD:
undetectable
1hzeB-6gsaD:
undetectable