SIMILAR PATTERNS OF AMINO ACIDS FOR 1HZ4_A_BEZA784

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aih HP1 INTEGRASE

(Haemophilus
virus HP1) 		PF00589
(Phage_integrase) 		4 HIS A 280
LEU A 278
LEU A 273
PRO A 274
 None
 1.31A 1hz4A-1aihA:
undetectable		 1hz4A-1aihA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		4 HIS A 263
LEU A 150
LEU A 147
PRO A 144
 None
 1.03A 1hz4A-1c4xA:
0.0		 1hz4A-1c4xA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 TRP A 387
HIS A 386
LEU A 508
PRO A 505
 None
HEM  A 601 (-3.8A)
None
None
 1.27A 1hz4A-1ebvA:
0.0		 1hz4A-1ebvA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02306
(Phage_G) 		4 HIS 2  58
LEU 2 147
LEU 2  56
PRO 2  29
 None
 1.01A 1hz4A-1gff2:
undetectable		 1hz4A-1gff2:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 LEU B 229
LEU B 226
PRO B 224
MET B 225
 None
 1.30A 1hz4A-1h4vB:
undetectable		 1hz4A-1h4vB:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hz4 MALT REGULATORY
PROTEIN

(Escherichia
coli) 		no annotation 6 TRP A  87
HIS A  88
LEU A 126
LEU A 129
PRO A 130
MET A 131
 None
BEZ  A 784 (-4.8A)
BEZ  A 784 ( 3.9A)
BEZ  A 784 (-3.8A)
BEZ  A 784 (-3.7A)
BEZ  A 784 (-4.4A)
 0.00A 1hz4A-1hz4A:
62.3		 1hz4A-1hz4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 HIS A 122
LEU A 127
LEU A 124
PRO A 131
 None
 1.29A 1hz4A-1j6uA:
0.0		 1hz4A-1j6uA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		4 HIS A 183
LEU A  82
LEU A 308
PRO A  80
 None
 1.14A 1hz4A-1jjiA:
0.0		 1hz4A-1jjiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		4 HIS A 188
LEU A  67
LEU A  71
PRO A  72
 None
 1.21A 1hz4A-1l8tA:
0.6		 1hz4A-1l8tA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 LEU A 133
LEU A 134
PRO A 135
MET A 136
 None
 1.33A 1hz4A-1la2A:
undetectable		 1hz4A-1la2A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 TRP A 102
LEU A  98
LEU A  38
PRO A  39
 152  A5001 (-4.7A)
None
None
None
 1.34A 1hz4A-1ndfA:
undetectable		 1hz4A-1ndfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 LEU A 497
LEU A 492
PRO A 489
MET A 491
 None
 1.18A 1hz4A-1o99A:
undetectable		 1hz4A-1o99A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		4 HIS A  19
LEU A 105
LEU A 199
PRO A 198
 None
 1.22A 1hz4A-1o9jA:
undetectable		 1hz4A-1o9jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ov2 ALPHA-2-MACROGLOBULI
N
RECEPTOR-ASSOCIATED
PROTEIN PRECURSOR

(Homo sapiens) 		PF06400
(Alpha-2-MRAP_N) 		4 HIS A  36
LEU A  37
LEU A  42
PRO A  39
 None
 1.07A 1hz4A-1ov2A:
2.5		 1hz4A-1ov2A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 HIS A 469
LEU A 390
LEU A 471
PRO A 474
 None
 1.04A 1hz4A-1pduA:
undetectable		 1hz4A-1pduA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pww LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		4 TRP A 570
LEU A 574
LEU A 576
PRO A 577
 None
 1.33A 1hz4A-1pwwA:
undetectable		 1hz4A-1pwwA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 LEU A 285
LEU A 207
PRO A 208
MET A 209
 None
 1.16A 1hz4A-1tz7A:
undetectable		 1hz4A-1tz7A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		4 HIS A  20
LEU A  73
LEU A  80
PRO A  81
 None
 1.12A 1hz4A-1vlpA:
undetectable		 1hz4A-1vlpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x51 A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE

(Homo sapiens) 		PF14815
(NUDIX_4) 		4 HIS A  84
LEU A  70
LEU A  80
PRO A  79
 None
 1.10A 1hz4A-1x51A:
undetectable		 1hz4A-1x51A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfg GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Escherichia
coli) 		PF13522
(GATase_6) 		4 TRP A 133
LEU A 111
LEU A 107
PRO A 106
 None
 1.19A 1hz4A-1xfgA:
undetectable		 1hz4A-1xfgA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 LEU A 105
LEU A 108
PRO A 109
MET A 110
 None
 0.94A 1hz4A-1xrsA:
1.2		 1hz4A-1xrsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]

(Yellow fever
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 TRP A 304
HIS A 307
LEU A 499
PRO A 524
 None
 1.22A 1hz4A-1yksA:
undetectable		 1hz4A-1yksA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6r TOXIN YOEB

(Escherichia
coli) 		PF06769
(YoeB_toxin) 		4 HIS A  50
LEU A  52
LEU A  48
PRO A  47
 None
 1.22A 1hz4A-2a6rA:
undetectable		 1hz4A-2a6rA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		4 TRP A 375
LEU A 346
LEU A 321
PRO A 388
 None
 1.31A 1hz4A-2bllA:
undetectable		 1hz4A-2bllA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA

(Human
mastadenovirus
C) 		PF01686
(Adeno_Penton_B) 		4 TRP A 376
LEU A 123
LEU A 466
PRO A 467
 None
 0.87A 1hz4A-2c6sA:
undetectable		 1hz4A-2c6sA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1y HYPOTHETICAL PROTEIN
TT0321

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 LEU A 118
LEU A 115
PRO A 112
MET A 113
 None
 0.96A 1hz4A-2d1yA:
undetectable		 1hz4A-2d1yA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejw HOMOSERINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 HIS A 146
LEU A 264
LEU A 258
PRO A 259
 None
 1.34A 1hz4A-2ejwA:
undetectable		 1hz4A-2ejwA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm8 TENA HOMOLOG/THI-4
THIAMINASE

(Pyrobaculum
aerophilum) 		PF03070
(TENA_THI-4) 		4 LEU A  26
LEU A  31
PRO A  32
MET A  33
 None
 1.27A 1hz4A-2gm8A:
undetectable		 1hz4A-2gm8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwy PROTEIN SMG5

(Homo sapiens) 		PF13638
(PIN_4) 		4 HIS A 866
LEU A 864
LEU A 868
PRO A 869
 None
 1.26A 1hz4A-2hwyA:
undetectable		 1hz4A-2hwyA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		4 TRP A 123
HIS A 135
LEU A 176
LEU A 182
 None
 1.27A 1hz4A-2ixnA:
undetectable		 1hz4A-2ixnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j28 50S RIBOSOMAL
PROTEIN L2

(Escherichia
coli) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 LEU C 191
LEU C 129
PRO C 130
MET C 131
 None
 1.35A 1hz4A-2j28C:
undetectable		 1hz4A-2j28C:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4d CRYPTOCHROME DASH

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 HIS A 480
LEU A 471
LEU A 474
PRO A 475
 None
 1.31A 1hz4A-2j4dA:
undetectable		 1hz4A-2j4dA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 TRP A 133
LEU A 111
LEU A 107
PRO A 106
 None
 1.27A 1hz4A-2j6hA:
undetectable		 1hz4A-2j6hA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9w VPS28-PROV PROTEIN

(Xenopus laevis) 		PF03997
(VPS28) 		4 TRP A 183
LEU A 157
LEU A 160
MET A 161
 None
 1.21A 1hz4A-2j9wA:
2.2		 1hz4A-2j9wA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ju1 ERYTHRONOLIDE
SYNTHASE

(Saccharopolyspora
erythraea) 		PF00550
(PP-binding) 		4 HIS A  80
LEU A  64
LEU A  72
PRO A  73
 None
 1.19A 1hz4A-2ju1A:
undetectable		 1hz4A-2ju1A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc5 HYDROGENASE-2 OPERON
PROTEIN HYBE

(Escherichia
coli) 		PF11939
(NiFe-hyd_HybE) 		4 LEU A 110
LEU A  62
PRO A 113
MET A  61
 None
 1.30A 1hz4A-2kc5A:
undetectable		 1hz4A-2kc5A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		4 HIS A 223
LEU A 196
LEU A 199
PRO A 200
 None
 1.04A 1hz4A-2o36A:
undetectable		 1hz4A-2o36A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 HIS A 102
LEU A 460
LEU A 457
PRO A 454
 None
 1.28A 1hz4A-2oajA:
undetectable		 1hz4A-2oajA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqg POSSIBLE
TRANSCRIPTIONAL
REGULATOR, ARSR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF12840
(HTH_20) 		4 HIS A  52
LEU A  38
LEU A  42
PRO A  43
 None
 0.94A 1hz4A-2oqgA:
undetectable		 1hz4A-2oqgA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		4 HIS A  73
LEU A  83
LEU A  71
PRO A 103
 None
 1.32A 1hz4A-2p17A:
undetectable		 1hz4A-2p17A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		4 LEU A 193
LEU A 170
PRO A 171
MET A 169
 None
 1.20A 1hz4A-2qvlA:
undetectable		 1hz4A-2qvlA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 100
LEU A 104
PRO A 105
MET A 106
 None
 1.20A 1hz4A-2rb9A:
undetectable		 1hz4A-2rb9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		4 LEU A 166
LEU A 129
PRO A 131
MET A 130
 None
 1.23A 1hz4A-2vrtA:
undetectable		 1hz4A-2vrtA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a98 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF07653
(SH3_2)
PF16172
(DOCK_N) 		4 TRP A 127
LEU A 144
LEU A 136
PRO A 137
 None
 1.07A 1hz4A-3a98A:
1.7		 1hz4A-3a98A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 HIS A1509
LEU A1515
LEU A1502
PRO A1503
 None
 1.17A 1hz4A-3av6A:
undetectable		 1hz4A-3av6A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxm URACIL-DNA
GLYCOSYLASE

(Leishmania
naiffi) 		PF03167
(UDG) 		4 HIS A 250
LEU A 231
LEU A 227
PRO A 226
 None
 1.20A 1hz4A-3cxmA:
undetectable		 1hz4A-3cxmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dt5 UNCHARACTERIZED
PROTEIN AF_0924

(Archaeoglobus
fulgidus) 		no annotation 4 LEU A 125
LEU A 128
PRO A 129
MET A 130
 None
 1.33A 1hz4A-3dt5A:
undetectable		 1hz4A-3dt5A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e35 UNCHARACTERIZED
PROTEIN SCO1997

(Streptomyces
coelicolor) 		PF09754
(PAC2) 		4 HIS A 206
LEU A 264
LEU A 268
PRO A 149
 None
 1.11A 1hz4A-3e35A:
undetectable		 1hz4A-3e35A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i42 RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY-LIKE)

(Methylobacillus
flagellatus) 		PF00072
(Response_reg) 		4 LEU A  84
LEU A  87
PRO A  88
MET A  89
 None
 1.29A 1hz4A-3i42A:
undetectable		 1hz4A-3i42A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm PRE-MRNA-SPLICING
FACTOR 6

(Saccharomyces
cerevisiae) 		PF06424
(PRP1_N) 		4 TRP G 842
LEU G 892
LEU G 895
MET G 896
 None
 1.29A 1hz4A-3jcmG:
undetectable		 1hz4A-3jcmG:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		4 HIS A 438
LEU A 191
LEU A 189
PRO A 208
 None
 1.32A 1hz4A-3my7A:
undetectable		 1hz4A-3my7A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		4 LEU A  52
LEU A 134
PRO A 135
MET A 136
 None
 1.01A 1hz4A-3na6A:
undetectable		 1hz4A-3na6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no3 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		4 HIS A  63
LEU A  91
LEU A 102
PRO A 103
 None
 0.91A 1hz4A-3no3A:
undetectable		 1hz4A-3no3A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 HIS A 861
LEU A 864
LEU A 855
PRO A 856
 None
 1.15A 1hz4A-4a7kA:
undetectable		 1hz4A-4a7kA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 4 LEU D  43
LEU D 311
PRO D 312
MET D 314
 None
 1.11A 1hz4A-4em6D:
undetectable		 1hz4A-4em6D:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7u METHYLOSOME SUBUNIT
PICLN

(Drosophila
melanogaster) 		no annotation 4 LEU Q6023
LEU Q6138
PRO Q6140
MET Q6139
 None
 1.32A 1hz4A-4f7uQ:
undetectable		 1hz4A-4f7uQ:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 HIS B 618
LEU B 882
LEU B 887
PRO B 888
 None
 1.22A 1hz4A-4f92B:
2.2		 1hz4A-4f92B:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 TRP A 219
LEU A 146
LEU A 159
PRO A 160
 None
 1.32A 1hz4A-4fffA:
undetectable		 1hz4A-4fffA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl9 ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASE

(Rhodospirillum
rubrum) 		PF03992
(ABM) 		4 HIS A  81
LEU A  21
LEU A  77
PRO A  76
 None
 1.26A 1hz4A-4hl9A:
undetectable		 1hz4A-4hl9A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		4 LEU A  48
LEU A 151
PRO A 152
MET A 153
 None
 1.32A 1hz4A-4hz8A:
undetectable		 1hz4A-4hz8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 HIS A 516
LEU A 437
LEU A 518
PRO A 521
 None
 1.31A 1hz4A-4jgvA:
undetectable		 1hz4A-4jgvA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 TRP A 718
LEU A 722
LEU A 602
PRO A 603
 GOL  A 805 (-3.6A)
GOL  A 805 ( 4.8A)
None
None
 1.28A 1hz4A-4ka8A:
undetectable		 1hz4A-4ka8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 HIS A 697
LEU A 689
LEU A 698
PRO A 700
 None
 1.17A 1hz4A-4ktpA:
3.1		 1hz4A-4ktpA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		4 HIS A 113
LEU A 170
LEU A 111
PRO A 106
 None
 1.12A 1hz4A-4lomA:
undetectable		 1hz4A-4lomA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum) 		PF04909
(Amidohydro_2) 		4 TRP A 237
LEU A 263
LEU A 266
PRO A 267
 None
 1.29A 1hz4A-4mupA:
undetectable		 1hz4A-4mupA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o01 BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 HIS A 116
LEU A  89
LEU A  97
PRO A  94
 None
 1.31A 1hz4A-4o01A:
undetectable		 1hz4A-4o01A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxp RIBONUCLEASE E

(Caulobacter
vibrioides) 		PF10150
(RNase_E_G) 		4 LEU A 224
LEU A 186
PRO A 188
MET A 187
 None
 1.23A 1hz4A-4oxpA:
undetectable		 1hz4A-4oxpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN

(Legionella
pneumophila) 		PF13855
(LRR_8) 		4 HIS A 181
LEU A 185
LEU A 207
PRO A 206
 None
 1.23A 1hz4A-4q62A:
undetectable		 1hz4A-4q62A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4quv DELTA(14)-STEROL
REDUCTASE

(Methylomicrobium
alcaliphilum) 		PF01222
(ERG4_ERG24) 		4 TRP A  25
LEU A  28
LEU A  32
PRO A  33
 None
 1.26A 1hz4A-4quvA:
undetectable		 1hz4A-4quvA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 HIS A 145
LEU A  56
LEU A  60
PRO A  61
 None
 1.27A 1hz4A-4y9lA:
1.3		 1hz4A-4y9lA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN

(Salmonella
enterica) 		PF01052
(FliMN_C)
PF16973
(FliN_N) 		4 HIS B  79
LEU B  62
LEU B  80
PRO B  83
 None
 1.06A 1hz4A-4yxcB:
undetectable		 1hz4A-4yxcB:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq9 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF12252
(SidE) 		4 HIS A 112
LEU A 123
LEU A 116
PRO A 117
 None
 1.32A 1hz4A-5bq9A:
undetectable		 1hz4A-5bq9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		4 LEU A 297
LEU A  37
PRO A  20
MET A  21
 None
 1.28A 1hz4A-5d86A:
undetectable		 1hz4A-5d86A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A  90
LEU A  93
PRO A  94
MET A  96
 None
 1.09A 1hz4A-5e8kA:
4.8		 1hz4A-5e8kA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eu0 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
rochalimae) 		PF02661
(Fic) 		4 HIS A 157
LEU A 147
LEU A 150
PRO A 151
 None
 0.64A 1hz4A-5eu0A:
undetectable		 1hz4A-5eu0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 172
LEU A 318
LEU A 316
PRO A 211
 None
 1.18A 1hz4A-5g3fA:
undetectable		 1hz4A-5g3fA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 HIS C 596
LEU C 725
LEU C 728
PRO C 729
 None
 1.20A 1hz4A-5g5gC:
undetectable		 1hz4A-5g5gC:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A  77
LEU A  98
PRO A  99
MET A 100
 None
None
None
NAG  A 803 (-3.8A)
 1.23A 1hz4A-5gs0A:
undetectable		 1hz4A-5gs0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		4 HIS A1509
LEU A1515
LEU A1502
PRO A1503
 None
 1.11A 1hz4A-5gutA:
undetectable		 1hz4A-5gutA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc8 PRENYLTRANSFERENCE
FOR PROTEIN

(Lavandula
lanata) 		PF01255
(Prenyltransf) 		4 HIS A  70
LEU A 246
LEU A 263
PRO A 264
 None
 1.25A 1hz4A-5hc8A:
undetectable		 1hz4A-5hc8A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp) 		4 HIS A1499
LEU A1000
LEU A1003
PRO A1004
 None
 1.26A 1hz4A-5hccA:
0.0		 1hz4A-5hccA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 HIS A 437
LEU A 392
LEU A 404
PRO A 405
 None
 1.19A 1hz4A-5hxaA:
undetectable		 1hz4A-5hxaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 HIS C 131
LEU C  44
LEU C  72
PRO C  71
 None
 1.23A 1hz4A-5ip7C:
undetectable		 1hz4A-5ip7C:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koa CELL DIVISION
PROTEIN ZAPD

(Escherichia
coli) 		PF07072
(ZapD) 		4 TRP A  18
LEU A 168
LEU A 164
PRO A 163
 None
 1.23A 1hz4A-5koaA:
3.2		 1hz4A-5koaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 HIS A 666
LEU A 932
LEU A 937
PRO A 938
 None
 1.15A 1hz4A-5m59A:
2.3		 1hz4A-5m59A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 4 LEU A 356
LEU A 352
PRO A 351
MET A 354
 None
 1.34A 1hz4A-5n6vA:
undetectable		 1hz4A-5n6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		4 TRP A  92
HIS A  93
LEU A  94
LEU A  97
 None
 1.31A 1hz4A-5nlaA:
undetectable		 1hz4A-5nlaA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		no annotation 4 HIS C 131
LEU C  44
LEU C  72
PRO C  71
 None
 1.23A 1hz4A-5w4uC:
undetectable		 1hz4A-5w4uC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		4 LEU G  20
LEU G  64
PRO G  65
MET G  63
 None
 1.35A 1hz4A-5x5yG:
undetectable		 1hz4A-5x5yG:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x87 BESTROPHIN

(Klebsiella
pneumoniae) 		no annotation 4 TRP A 123
LEU A 141
LEU A 142
PRO A 143
 None
 1.30A 1hz4A-5x87A:
2.8		 1hz4A-5x87A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 4 HIS A 637
LEU A 641
LEU A 638
PRO A 653
 None
 1.07A 1hz4A-5xpgA:
undetectable		 1hz4A-5xpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1a -

(-) 		no annotation 4 HIS A 231
LEU A 200
LEU A 157
PRO A 156
 None
 1.35A 1hz4A-5y1aA:
undetectable		 1hz4A-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhu MYELIN REGULATORY
FACTOR

(Homo sapiens) 		no annotation 4 LEU A 355
LEU A 363
PRO A 364
MET A 365
 None
 0.95A 1hz4A-5yhuA:
undetectable		 1hz4A-5yhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 4 HIS A 157
LEU A 165
LEU A 167
PRO A 168
 None
 1.21A 1hz4A-5yl7A:
undetectable		 1hz4A-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 4 TRP A 303
LEU A 290
LEU A 293
PRO A 294
 None
 1.16A 1hz4A-5yo8A:
3.1		 1hz4A-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhu MYELIN REGULATORY
FACTOR

(Homo sapiens) 		no annotation 4 LEU A 355
LEU A 363
PRO A 364
MET A 365
 None
 0.99A 1hz4A-5zhuA:
undetectable		 1hz4A-5zhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk6 HENDRA VIRUS MATRIX
PROTEIN

(Hendra
henipavirus) 		no annotation 4 HIS A 238
LEU A 206
LEU A 237
MET A 236
 None
 1.13A 1hz4A-6bk6A:
undetectable		 1hz4A-6bk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 TRP A 390
LEU A 152
LEU A 388
PRO A 387
 None
 1.34A 1hz4A-6chjA:
undetectable		 1hz4A-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckg D-GLYCERATE 3-KINASE

(Cryptococcus
neoformans) 		no annotation 4 HIS A 213
LEU A 281
LEU A 173
PRO A 172
 None
 1.24A 1hz4A-6ckgA:
undetectable		 1hz4A-6ckgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE

(Synechocystis
sp. PCC 6803;
Deinococcus
radiodurans) 		no annotation 4 HIS A 116
LEU A  89
LEU A  97
PRO A  94
 None
 1.29A 1hz4A-6fhtA:
undetectable		 1hz4A-6fhtA:
undetectable