SIMILAR PATTERNS OF AMINO ACIDS FOR 1HXW_B_RITB301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b0k | PROTEIN (ACONITASE) (Sus scrofa) |
PF00330(Aconitase)PF00694(Aconitase_C) | 5 | GLY A 353GLY A 414ILE A 415PRO A 391ILE A 355 | None | 1.10A | 1hxwA-1b0kA:undetectable | 1hxwA-1b0kA:9.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e5m | BETA KETOACYL ACYLCARRIER PROTEINSYNTHASE II (Synechocystissp. PCC 6803) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 238GLY A 109ILE A 108VAL A 355ILE A 352 | None | 1.07A | 1hxwA-1e5mA:undetectable | 1hxwA-1e5mA:13.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ASP A 29GLY A 48PRO A 81VAL A 82ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-2.7A)A79 A 800 (-4.1A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 1.00A | 1hxwA-1hvcA:14.3 | 1hxwA-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ASP A 29GLY A 48VAL A 82ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-2.8A)A79 A 800 (-3.6A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.78A | 1hxwA-1hvcA:14.3 | 1hxwA-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-2.8A)A79 A 800 ( 4.9A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.51A | 1hxwA-1hvcA:14.3 | 1hxwA-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 (-2.7A)A79 A 800 ( 4.7A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.43A | 1hxwA-1hvcA:14.3 | 1hxwA-1hvcA:98.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcx | DIHYDROPYRIMIDINASERELATED PROTEIN-1 (Mus musculus) |
PF01979(Amidohydro_1) | 5 | ASP A 406GLY A 68ILE A 66VAL A 35ILE A 42 | None | 1.07A | 1hxwA-1kcxA:undetectable | 1hxwA-1kcxA:11.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrt | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Tritrichomonassuis) |
PF00478(IMPDH) | 5 | GLY A 288ASP A 261GLY A 235VAL A 247ILE A 238 | NoneTAD A 901 (-2.3A)NoneNoneNone | 0.95A | 1hxwA-1lrtA:undetectable | 1hxwA-1lrtA:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mew | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Tritrichomonassuis) |
PF00478(IMPDH)PF00571(CBS) | 5 | GLY A 288ASP A 261GLY A 235VAL A 247ILE A 238 | NoneNAD A 987 (-2.5A)NoneNoneNone | 0.88A | 1hxwA-1mewA:undetectable | 1hxwA-1mewA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1php | 3-PHOSPHOGLYCERATEKINASE (Geobacillusstearothermophilus) |
PF00162(PGK) | 5 | GLY A 350ASP A 352GLY A 194ILE A 193ILE A 348 | ADP A 396 (-3.6A) MG A 395 ( 3.0A)NoneNoneNone | 1.09A | 1hxwA-1phpA:undetectable | 1hxwA-1phpA:15.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 5 | ASP A 25GLY A 27ASP A 29ASP A 30ILE A 84 | None | 0.65A | 1hxwA-1q9pA:10.2 | 1hxwA-1q9pA:93.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s5t | DIHYDRODIPICOLINATESYNTHASE (Escherichiacoli) |
PF00701(DHDPS) | 5 | GLY A 201GLY A 159ILE A 160VAL A 40ILE A 6 | None | 1.13A | 1hxwA-1s5tA:undetectable | 1hxwA-1s5tA:15.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.33A | 1hxwA-1sivA:18.7 | 1hxwA-1sivA:50.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 25GLY A 27GLY A 48PRO A 81ILE A 84 | None | 0.75A | 1hxwA-1sivA:18.7 | 1hxwA-1sivA:50.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u1h | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Arabidopsisthaliana) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 5 | ASP A 664GLY A 692ILE A 693VAL A 687ILE A 661 | None | 1.01A | 1hxwA-1u1hA:undetectable | 1hxwA-1u1hA:7.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w3f | HEMOLYTIC LECTINFROM LAETIPORUSSULPHUREUS (Laetiporussulphureus) |
PF03318(ETX_MTX2) | 5 | GLY A 241GLY A 296ILE A 297PRO A 221VAL A 220 | None | 0.95A | 1hxwA-1w3fA:undetectable | 1hxwA-1w3fA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x7h | PUTATIVE KETOACYLREDUCTASE (Streptomycescoelicolor) |
PF00106(adh_short) | 5 | GLY A 117ASP A 63GLY A 13VAL A 74ILE A 70 | NoneNDP A 301 (-3.7A)NDP A 301 (-3.3A)NoneNone | 1.00A | 1hxwA-1x7hA:undetectable | 1hxwA-1x7hA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yr2 | PROLYLOLIGOPEPTIDASE (Novosphingobiumcapsulatum) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 5 | GLY A 539ASP A 537GLY A 529PRO A 475VAL A 474 | None | 1.02A | 1hxwA-1yr2A:undetectable | 1hxwA-1yr2A:8.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bkl | PROLYL ENDOPEPTIDASE (Myxococcusxanthus) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 5 | GLY A 497ASP A 495GLY A 487PRO A 431VAL A 430 | None | 1.03A | 1hxwA-2bklA:undetectable | 1hxwA-2bklA:10.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1z | UDP-GLUCOSEFLAVONOID 3-OGLYCOSYLTRANSFERASE (Vitis vinifera) |
PF00201(UDPGT) | 5 | GLY A 363GLY A 415ILE A 409VAL A 382ILE A 388 | None | 1.03A | 1hxwA-2c1zA:undetectable | 1hxwA-2c1zA:12.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw6 | BLL6730 PROTEIN (Bradyrhizobiumjaponicum) |
PF13378(MR_MLE_C) | 5 | GLY A 352GLY A 373ILE A 372VAL A 148ILE A 364 | None | 1.06A | 1hxwA-2dw6A:undetectable | 1hxwA-2dw6A:13.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 29GLY A 55PRO A 86VAL A 87ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 ( 4.9A)LP1 A 201 (-4.2A) | 0.44A | 1hxwA-2fmbA:15.1 | 1hxwA-2fmbA:31.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | ASP A 25GLY A 27GLY A 54VAL A 87ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.6A)LP1 A 201 ( 4.9A)LP1 A 201 (-4.2A) | 0.71A | 1hxwA-2fmbA:15.1 | 1hxwA-2fmbA:31.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gzl | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Escherichiacoli) |
PF02542(YgbB) | 5 | GLY A 37ASP A 8GLY A 145PRO A 103ILE A 20 | None ZN A 900 ( 2.4A)NoneNoneNone | 0.99A | 1hxwA-2gzlA:undetectable | 1hxwA-2gzlA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hdn | ELONGATION FACTOREF-TU (Escherichiacoli) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | GLY B 316ASP B 314GLY B 353ILE B 310ILE B 60 | None | 1.09A | 1hxwA-2hdnB:undetectable | 1hxwA-2hdnB:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l3o | INTERLEUKIN 3 (Mus musculus) |
PF02059(IL3) | 5 | ASP A 125ASP A 123GLY A 86VAL A 119ILE A 121 | None | 1.11A | 1hxwA-2l3oA:undetectable | 1hxwA-2l3oA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5p | FERRIPYOVERDINERECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07660(STN)PF07715(Plug) | 5 | GLY A 63ASP A 67ILE A 85VAL A 106ILE A 113 | None | 1.10A | 1hxwA-2o5pA:undetectable | 1hxwA-2o5pA:8.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2odl | ADHESIN (Haemophilusinfluenzae) |
PF05860(Haemagg_act) | 5 | GLY A 354ASP A 356GLY A 422VAL A 418ILE A 391 | None | 1.12A | 1hxwA-2odlA:undetectable | 1hxwA-2odlA:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pgw | MUCONATECYCLOISOMERASE (Sinorhizobiummeliloti) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 355GLY A 49ILE A 305PRO A 272ILE A 278 | None | 1.08A | 1hxwA-2pgwA:undetectable | 1hxwA-2pgwA:15.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ASP A 29GLY A 48PRO A 81ILE A 84 | AB1 A 501 (-2.4A)AB1 A 501 ( 3.3A)AB1 A 501 (-4.2A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.96A | 1hxwA-2rkfA:20.9 | 1hxwA-2rkfA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ASP A 30GLY A 49ILE A 50ILE A 84 | AB1 A 501 (-2.4A)AB1 A 501 (-3.8A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 ( 4.2A) | 0.99A | 1hxwA-2rkfA:20.9 | 1hxwA-2rkfA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | AB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 ( 3.3A)AB1 A 501 (-3.8A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.42A | 1hxwA-2rkfA:20.9 | 1hxwA-2rkfA:86.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsm | HEMAGGLUTININ-NEURAMINIDASE (Nipahhenipavirus) |
PF00423(HN) | 5 | GLY A 523ASP A 510ILE A 520VAL A 484ILE A 485 | None | 1.06A | 1hxwA-2vsmA:undetectable | 1hxwA-2vsmA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y23 | MYOMESIN (Homo sapiens) |
PF07679(I-set) | 5 | ASP A1401GLY A1409ILE A1410VAL A1428ILE A1389 | None | 0.80A | 1hxwA-2y23A:undetectable | 1hxwA-2y23A:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y89 | PHOSPHORIBOSYLISOMERASE A (Mycobacteriumtuberculosis) |
PF00977(His_biosynth) | 5 | ASP A 171GLY A 176ASP A 184GLY A 136ILE A 134 | None | 1.04A | 1hxwA-2y89A:undetectable | 1hxwA-2y89A:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b1b | CARBONIC ANHYDRASE 1 (Chlamydomonasreinhardtii) |
PF00194(Carb_anhydrase) | 5 | GLY A 257GLY A 368PRO A 73VAL A 72ILE A 70 | None | 1.00A | 1hxwA-3b1bA:undetectable | 1hxwA-3b1bA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bmw | CYCLOMALTODEXTRINGLUCANOTRANSFERASE (Thermoanaerobacteriumthermosulfurigenes) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 5 | GLY A 502ASP A 3GLY A 521VAL A 529ILE A 517 | None | 1.12A | 1hxwA-3bmwA:undetectable | 1hxwA-3bmwA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c26 | PUTATIVEACETYLTRANSFERASETA0821 (Thermoplasmaacidophilum) |
PF00583(Acetyltransf_1) | 5 | ASP A 45GLY A 87ILE A 74VAL A 56ILE A 52 | NO3 A 266 (-3.1A)EDO A 269 (-3.4A)NoneNoneNone | 1.04A | 1hxwA-3c26A:undetectable | 1hxwA-3c26A:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8b | FIDGETIN-LIKEPROTEIN 1 (Homo sapiens) |
PF00004(AAA)PF09336(Vps4_C) | 5 | GLY A 543ILE A 539PRO A 433VAL A 417ILE A 437 | None | 1.09A | 1hxwA-3d8bA:undetectable | 1hxwA-3d8bA:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfy | MUCONATECYCLOISOMERASE (Thermotogamaritima) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ASP A 188GLY A 291ILE A 290VAL A 157ILE A 186 | MG A 401 (-2.7A)NoneNoneNoneNone | 0.84A | 1hxwA-3dfyA:undetectable | 1hxwA-3dfyA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f6m | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Yersinia pestis) |
PF02542(YgbB) | 5 | GLY A 39ASP A 8GLY A 147PRO A 105ILE A 22 | None | 1.04A | 1hxwA-3f6mA:undetectable | 1hxwA-3f6mA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fby | CARTILAGE OLIGOMERICMATRIX PROTEIN (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 5 | ASP A 369GLY A 368ASP A 373PRO A 391ILE A 375 | CA A 809 ( 4.9A) CA A 809 ( 4.4A)None CA A 812 (-4.7A)None | 0.99A | 1hxwA-3fbyA:undetectable | 1hxwA-3fbyA:9.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gla | LOW MOLECULAR WEIGHTHEAT SHOCK PROTEIN (Xanthomonascitri) |
PF00011(HSP20) | 5 | ASP A 118ASP A 116GLY A 76ILE A 77ILE A 133 | None | 1.02A | 1hxwA-3glaA:undetectable | 1hxwA-3glaA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5g | MYOSIN HEAVY CHAINISOFORM A (Doryteuthispealeii) |
PF00063(Myosin_head)PF00612(IQ)PF02736(Myosin_N) | 5 | GLY A 264ASP A 266GLY A 460ILE A 459ILE A 224 | None | 1.07A | 1hxwA-3i5gA:undetectable | 1hxwA-3i5gA:8.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kvo | HYDROXYSTEROIDDEHYDROGENASE-LIKEPROTEIN 2 (Homo sapiens) |
PF00106(adh_short) | 5 | GLY A 128ASP A 74GLY A 17VAL A 85ILE A 81 | NoneNAP A 501 (-3.5A)NAP A 501 (-3.3A)NoneNone | 1.03A | 1hxwA-3kvoA:undetectable | 1hxwA-3kvoA:15.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ASP A 30GLY A 48PRO A 81VAL A 82ILE A 84 | None | 1.18A | 1hxwA-3mwsA:20.2 | 1hxwA-3mwsA:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ASP A 29ASP A 30GLY A 48PRO A 81VAL A 82ILE A 84 | None | 0.99A | 1hxwA-3mwsA:20.2 | 1hxwA-3mwsA:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ASP A 29GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | None | 0.46A | 1hxwA-3mwsA:20.2 | 1hxwA-3mwsA:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3soe | MEMBRANE-ASSOCIATEDGUANYLATE KINASE, WWAND PDZDOMAIN-CONTAININGPROTEIN 3 (Homo sapiens) |
no annotation | 5 | ASP A 642GLY A 641GLY A 681VAL A 602ILE A 677 | None | 1.04A | 1hxwA-3soeA:undetectable | 1hxwA-3soeA:22.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)017 A 201 (-4.2A)017 A 201 (-4.0A)017 A 201 (-3.3A)None | 0.75A | 1hxwA-3t3cA:18.7 | 1hxwA-3t3cA:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3to3 | PETROBACTINBIOSYNTHESIS PROTEINASBB (Bacillusanthracis) |
PF04183(IucA_IucC)PF06276(FhuF) | 5 | GLY A 361ASP A 353ILE A 366PRO A 242VAL A 243 | None | 1.10A | 1hxwA-3to3A:undetectable | 1hxwA-3to3A:9.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ASP A 29ASP A 30GLY A 48PRO A 81ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-3.3A)017 A 201 (-4.6A)None017 A 201 (-4.1A)017 A 201 (-4.7A) | 1.06A | 1hxwA-3ttpA:19.7 | 1hxwA-3ttpA:80.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ASP A 30GLY A 48PRO A 81ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-4.6A)None017 A 201 (-4.1A)017 A 201 (-4.7A) | 1.09A | 1hxwA-3ttpA:19.7 | 1hxwA-3ttpA:80.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.3A)017 A 201 (-4.6A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.57A | 1hxwA-3ttpA:19.7 | 1hxwA-3ttpA:80.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 29ASP A 30GLY A 48PRO A 79ILE A 32 | 017 A 201 (-3.3A)017 A 201 (-4.6A)NoneNoneNone | 1.12A | 1hxwA-3ttpA:19.7 | 1hxwA-3ttpA:80.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81 | 017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.2A)017 A 201 ( 4.0A)017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.49A | 1hxwA-3u7sA:20.0 | 1hxwA-3u7sA:80.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25GLY A 27ASP A 29PRO A 81VAL A 82 | None | 0.56A | 1hxwA-3uhlA:16.3 | 1hxwA-3uhlA:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vbe | BETA-CYANOALNINESYNTHASE (Glycine max) |
PF00291(PALP) | 5 | GLY A 239GLY A 232ILE A 229PRO A 345VAL A 343 | NonePLP A 500 (-3.3A)NonePLP A 500 (-4.2A)None | 1.12A | 1hxwA-3vbeA:undetectable | 1hxwA-3vbeA:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w2i | NADH-CYTOCHROME B5REDUCTASE 3 (Sus scrofa) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | ASP A 72ASP A 73GLY A 43ILE A 5PRO A 36 | None | 0.91A | 1hxwA-3w2iA:undetectable | 1hxwA-3w2iA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aef | NEOPULLULANASE(ALPHA-AMYLASE II) (Pyrococcusfuriosus) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16561(AMPK1_CBM) | 5 | GLY A 528GLY A 452ILE A 435PRO A 201ILE A 205 | None | 1.10A | 1hxwA-4aefA:undetectable | 1hxwA-4aefA:9.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b90 | DIHYDROPYRIMIDINASE-RELATED PROTEIN 5 (Homo sapiens) |
PF01979(Amidohydro_1) | 5 | ASP A 399GLY A 61ILE A 59VAL A 28ILE A 35 | None | 1.10A | 1hxwA-4b90A:undetectable | 1hxwA-4b90A:11.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b92 | DIHYDROPYRIMIDINASE-RELATED PROTEIN 5 (Homo sapiens) |
PF01979(Amidohydro_1) | 5 | ASP A 399GLY A 61ILE A 59VAL A 28ILE A 35 | None | 1.09A | 1hxwA-4b92A:undetectable | 1hxwA-4b92A:12.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cw5 | DFNA (Bacillusvelezensis) |
PF03060(NMO) | 5 | GLY A 559GLY A 732ILE A 731PRO A 542ILE A 539 | FMN A1753 (-3.0A)NoneNoneNoneNone | 0.99A | 1hxwA-4cw5A:undetectable | 1hxwA-4cw5A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fff | LEVANFRUCTOTRANSFERASE (Paenarthrobacterureafaciens) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 5 | ASP A 292GLY A 294ASP A 296ILE A 467PRO A 363 | None | 0.89A | 1hxwA-4fffA:undetectable | 1hxwA-4fffA:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gz7 | DIHYDROPYRIMIDINASE (Tetraodonnigroviridis) |
PF01979(Amidohydro_1) | 5 | ASP A 396GLY A 58ILE A 56VAL A 25ILE A 32 | None | 1.10A | 1hxwA-4gz7A:undetectable | 1hxwA-4gz7A:13.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hb9 | SIMILARITIES WITHPROBABLEMONOOXYGENASE (Photorhabduslaumondii) |
PF01494(FAD_binding_3) | 5 | GLY A 11ASP A 336GLY A 159ILE A 6VAL A 26 | FAD A 501 (-3.5A)NoneNoneFAD A 501 (-4.5A)None | 1.02A | 1hxwA-4hb9A:undetectable | 1hxwA-4hb9A:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jqp | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE (Paraburkholderiaphymatum) |
PF04166(PdxA) | 5 | ASP A 128GLY A 210ILE A 211VAL A 300ILE A 305 | None | 0.96A | 1hxwA-4jqpA:undetectable | 1hxwA-4jqpA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k5u | VARIABLE LYMPHOCYTERECEPTOR (Petromyzonmarinus) |
no annotation | 5 | GLY B 63GLY B 18PRO B 25VAL B 24ILE B 42 | None | 0.92A | 1hxwA-4k5uB:undetectable | 1hxwA-4k5uB:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpn | NUCLEOSIDEN-RIBOHYDROLASE 1 (Physcomitrellapatens) |
PF01156(IU_nuc_hydro) | 5 | GLY A 27ASP A 29GLY A 142ILE A 51ILE A 34 | None CA A 400 ( 4.5A) CA A 400 ( 4.4A)NoneNone | 0.94A | 1hxwA-4kpnA:undetectable | 1hxwA-4kpnA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpo | NUCLEOSIDEN-RIBOHYDROLASE 3 (Zea mays) |
PF01156(IU_nuc_hydro) | 5 | GLY A 10ASP A 12GLY A 124ILE A 34ILE A 17 | None CA A 401 ( 4.8A) CA A 401 ( 4.3A)NoneNone | 0.86A | 1hxwA-4kpoA:undetectable | 1hxwA-4kpoA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lry | PTS-DEPENDENTDIHYDROXYACETONEKINASE,DIHYDROXYACETONE-BINDING SUBUNIT DHAK (Escherichiacoli) |
PF02733(Dak1) | 5 | GLY A 219GLY A 327ILE A 189VAL A 150ILE A 217 | None | 1.05A | 1hxwA-4lryA:undetectable | 1hxwA-4lryA:17.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 29ASP A 30GLY A 48PRO A 81ILE A 84 | RIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 (-3.2A)RIT A 500 (-4.8A)RIT A 500 (-4.8A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.91A | 1hxwA-4njvA:20.7 | 1hxwA-4njvA:87.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | RIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 (-3.2A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.40A | 1hxwA-4njvA:20.7 | 1hxwA-4njvA:87.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nyn | RIBONUCLEASE HI (Halobacteriumsalinarum) |
PF13456(RVT_3) | 5 | GLY A 171ASP A 173ASP A 174GLY A 67ILE A 134 | None | 1.12A | 1hxwA-4nynA:undetectable | 1hxwA-4nynA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r1u | CINNAMOYL COAREDUCTASE (Medicagotruncatula) |
PF01370(Epimerase) | 5 | GLY A 97ASP A 59GLY A 8VAL A 70ILE A 66 | None | 0.92A | 1hxwA-4r1uA:undetectable | 1hxwA-4r1uA:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rlb | CARBAPENEM-ASSOCIATED RESISTANCE PROTEIN (Acinetobacterbaumannii) |
no annotation | 5 | GLY A 196ASP A 201ASP A 123GLY A 192ILE A 188 | None | 0.94A | 1hxwA-4rlbA:undetectable | 1hxwA-4rlbA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rlb | CARBAPENEM-ASSOCIATED RESISTANCE PROTEIN (Acinetobacterbaumannii) |
no annotation | 6 | GLY A 196ASP A 201GLY A 192ILE A 188VAL A 120ILE A 122 | None | 1.21A | 1hxwA-4rlbA:undetectable | 1hxwA-4rlbA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u8g | PUTATIVEUNCHARACTERIZEDPROTEIN GBS1891 (Streptococcusagalactiae) |
PF13561(adh_short_C2) | 5 | ASP A 45GLY A 21GLY A 100ILE A 101ILE A 46 | None | 1.09A | 1hxwA-4u8gA:undetectable | 1hxwA-4u8gA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u8g | PUTATIVEUNCHARACTERIZEDPROTEIN GBS1891 (Streptococcusagalactiae) |
PF13561(adh_short_C2) | 5 | ASP A 71GLY A 21ILE A 19VAL A 82ILE A 78 | None | 0.88A | 1hxwA-4u8gA:undetectable | 1hxwA-4u8gA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5w | RIBULOSEBISPHOSPHATECARBOXYLASE/OXYGENASE ACTIVASE,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00004(AAA) | 5 | GLY A 260ASP A 265ILE A 284VAL A 273ILE A 272 | None | 1.11A | 1hxwA-4w5wA:undetectable | 1hxwA-4w5wA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x4j | PUTATIVE OXYGENASE (Amycolatopsisorientalis) |
PF01494(FAD_binding_3) | 5 | GLY A 19GLY A 27ILE A 26VAL A 149ILE A 7 | None | 1.02A | 1hxwA-4x4jA:undetectable | 1hxwA-4x4jA:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9w | ASPARTIC ACIDENDOPEPTIDASE SAPP2 (Candidaparapsilosis) |
PF00026(Asp) | 5 | ASP A 32GLY A 34ASP A 37GLY A 76ILE A 116 | None | 0.73A | 1hxwA-4y9wA:7.5 | 1hxwA-4y9wA:16.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | ASP A 32GLY A 34ASP A 36GLY A 58ILE A 100 | 4B1 A 201 (-2.9A)4B1 A 201 ( 4.6A)4B1 A 201 (-4.4A)4B1 A 201 (-3.4A)4B1 A 201 (-4.8A) | 0.45A | 1hxwA-4ydfA:13.2 | 1hxwA-4ydfA:32.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z38 | MLNA (Bacillusvelezensis) |
no annotation | 5 | GLY A 576GLY A 748ILE A 747PRO A 559ILE A 556 | FMN A 900 (-3.5A)NoneNoneNoneNone | 1.06A | 1hxwA-4z38A:undetectable | 1hxwA-4z38A:13.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z9x | GLUCONATE5-DEHYDROGENASE (Streptococcuspyogenes) |
PF13561(adh_short_C2) | 5 | ASP A 66GLY A 16ILE A 14VAL A 77ILE A 73 | None | 0.94A | 1hxwA-4z9xA:undetectable | 1hxwA-4z9xA:18.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | GLY A 27ASP A 29ASP A 30GLY A 49ILE A 84 | None | 0.90A | 1hxwA-5b18A:18.2 | 1hxwA-5b18A:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | GLY A 27ASP A 29ASP A 30PRO A 81ILE A 84 | None | 0.58A | 1hxwA-5b18A:18.2 | 1hxwA-5b18A:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bok | FERREDOXIN (Diaphorobactersp. DS2) |
PF00355(Rieske) | 5 | GLY A 55GLY A 21ILE A 20VAL A 73ILE A 62 | None | 1.05A | 1hxwA-5bokA:undetectable | 1hxwA-5bokA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ilg | PHOTORECEPTORDEHYDROGENASE,ISOFORM C (Drosophilamelanogaster) |
PF00106(adh_short) | 5 | ASP A 232ASP A 85GLY A 174VAL A 178ILE A 131 | None | 1.10A | 1hxwA-5ilgA:undetectable | 1hxwA-5ilgA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j7n | LOW MOLECULAR WEIGHTHEAT SHOCK PROTEIN (Xylellafastidiosa) |
PF00011(HSP20) | 5 | ASP A 119ASP A 117GLY A 77ILE A 78ILE A 134 | None | 1.04A | 1hxwA-5j7nA:undetectable | 1hxwA-5j7nA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mm2 | CAPSID PROTEIN VP4C (Nora virus) |
no annotation | 5 | GLY A 118GLY A 161ILE A 212VAL A 54ILE A 259 | None | 0.99A | 1hxwA-5mm2A:undetectable | 1hxwA-5mm2A:17.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.49A | 1hxwA-5t2zA:20.0 | 1hxwA-5t2zA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u1w | P2X PURINOCEPTOR (Ailuropodamelanoleuca) |
PF00864(P2X_receptor) | 5 | ASP A 240GLY A 253ILE A 254VAL A 104ILE A 315 | None | 1.09A | 1hxwA-5u1wA:undetectable | 1hxwA-5u1wA:15.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vto | BLASTICIDIN M (Streptomycesgriseochromogenes) |
no annotation | 5 | GLY A 101ASP A 80ILE A 93VAL A 132ILE A 106 | None | 1.09A | 1hxwA-5vtoA:undetectable | 1hxwA-5vtoA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ybw | ASPARTATE RACEMASE (Scapharcabroughtonii) |
no annotation | 5 | ASP A 244GLY A 245GLY A 295ILE A 290PRO A 331 | NoneLLP A 63 ( 4.2A)NoneNoneNone | 1.07A | 1hxwA-5ybwA:undetectable | 1hxwA-5ybwA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8z | ADP-DEPENDENTPHOSPHOFRUCTOKINASE (Methanosarcinales) |
no annotation | 5 | ASP A 404GLY A 128ILE A 129VAL A 390ILE A 406 | None | 1.03A | 1hxwA-6c8zA:undetectable | 1hxwA-6c8zA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fiv | RETROPEPSIN (Felineimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 30GLY A 32ASP A 34GLY A 58VAL A 99 | 3TL A 201 (-3.5A)3TL A 201 (-3.4A)3TL A 201 (-3.9A)3TL A 201 (-3.4A)None | 0.62A | 1hxwA-6fivA:15.5 | 1hxwA-6fivA:28.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | ASP A 25ASP A 29ASP A 30GLY A 48PRO A 81ILE A 84 | NIU A 100 (-2.8A)NoneNoneNoneNoneNone | 1.10A | 1hxwA-6upjA:18.1 | 1hxwA-6upjA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | ASP A 25ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | NIU A 100 (-2.8A)NoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)NoneNone | 1.37A | 1hxwA-6upjA:18.1 | 1hxwA-6upjA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-4.5A)NoneNoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)NoneNone | 0.90A | 1hxwA-6upjA:18.1 | 1hxwA-6upjA:48.48 |