SIMILAR PATTERNS OF AMINO ACIDS FOR 1HXB_A_ROCA100_4

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bru ELASTASE

(Sus scrofa) 		PF00089
(Trypsin) 		4 GLY P 184
ASP P 186
GLY P  18
THR P 146
 None
 0.97A 1hxbB-1bruP:
undetectable		 1hxbB-1bruP:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
no annotation 		4 GLY C  13
ASP A 398
GLY A  13
THR A  41
 None
None
FAD  A 699 (-3.4A)
None
 1.02A 1hxbB-1fcdC:
undetectable		 1hxbB-1fcdC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 350
ASP A 420
GLY A 112
THR A 116
 None
None
FAD  A 600 (-3.3A)
None
 1.07A 1hxbB-1gpeA:
undetectable		 1hxbB-1gpeA:
9.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 GLY A  27
ASP A  29
GLY A  48
THR A  80
 A79  A 800 (-3.0A)
A79  A 800 (-2.7A)
A79  A 800 (-4.1A)
None
 0.35A 1hxbB-1hvcA:
14.1		 1hxbB-1hvcA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 GLY A  27
ASP A  29
GLY A  48
THR A  80
 A79  A 800 (-3.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.6A)
None
 0.43A 1hxbB-1hvcA:
14.1		 1hxbB-1hvcA:
48.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLY A 322
ASP A 355
GLY A 362
THR A 368
 None
 1.04A 1hxbB-1j0nA:
undetectable		 1hxbB-1j0nA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jrf SUBGROUP A ROUS
SARCOMA VIRUS
RECEPTORS PG800 AND
PG950

(Coturnix
japonica) 		PF00057
(Ldl_recept_a) 		4 GLY A  38
ASP A  40
GLY A  31
THR A  46
 None
CA  A  48 (-3.9A)
None
None
 0.98A 1hxbB-1jrfA:
undetectable		 1hxbB-1jrfA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkv HYPOTHETICAL PROTEIN
YJHP

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 GLY A  97
ASP A  94
GLY A  44
THR A  63
 None
 0.72A 1hxbB-1nkvA:
undetectable		 1hxbB-1nkvA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT

(Paracoccus
denitrificans) 		no annotation 4 GLY B 297
ASP B 302
GLY B 315
THR B  18
 None
 0.96A 1hxbB-1pbyB:
undetectable		 1hxbB-1pbyB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3g ADENYLATE KINASE

(Sporosarcina
globispora) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 GLY A  32
ASP A  84
GLY A   7
THR A  89
 AP5  A 218 (-3.6A)
AP5  A 218 ( 4.7A)
None
None
 1.00A 1hxbB-1s3gA:
undetectable		 1hxbB-1s3gA:
17.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		4 GLY A  27
ASP A  29
GLY A  48
THR A  80
 None
 0.29A 1hxbB-1sivA:
18.3		 1hxbB-1sivA:
50.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY A  19
ASP A 159
GLY A 184
THR A 213
 None
 0.85A 1hxbB-1spjA:
undetectable		 1hxbB-1spjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 GLY A  15
ASP A 465
GLY A 382
THR A 391
 None
 0.98A 1hxbB-1sqjA:
undetectable		 1hxbB-1sqjA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tl7 ADENYLATE CYCLASE,
TYPE V

(Canis lupus) 		PF00211
(Guanylate_cyc) 		4 GLY A 399
ASP A 396
GLY A 439
THR A 415
 ONM  A 100 (-3.1A)
MN  A 582 (-2.7A)
ONM  A 100 (-3.6A)
None
 0.96A 1hxbB-1tl7A:
undetectable		 1hxbB-1tl7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		4 GLY A 117
ASP A 135
GLY A 121
THR A 176
 None
 1.02A 1hxbB-1txoA:
undetectable		 1hxbB-1txoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 770
ASP A 736
GLY A 783
THR A 775
 None
 0.90A 1hxbB-1v7vA:
undetectable		 1hxbB-1v7vA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		4 GLY A 103
ASP A  95
GLY A  70
THR A 116
 None
SO4  A 904 (-4.2A)
SO4  A 902 (-3.3A)
None
 0.99A 1hxbB-1wkrA:
7.6		 1hxbB-1wkrA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 GLY A 389
ASP A 387
GLY A 382
THR A 338
 None
 1.01A 1hxbB-1wqlA:
undetectable		 1hxbB-1wqlA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		4 GLY A  43
ASP A  41
GLY A 184
THR A  26
 None
 1.02A 1hxbB-1ynaA:
undetectable		 1hxbB-1ynaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoa PUTATIVE
FLAVOPROTEIN

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		4 GLY A 154
ASP A 152
GLY A  16
THR A  32
 None
 0.90A 1hxbB-1yoaA:
undetectable		 1hxbB-1yoaA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zip ADENYLATE KINASE

(Geobacillus
stearothermophilus) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 GLY A  32
ASP A  84
GLY A   7
THR A  89
 AP5  A 218 (-3.6A)
MN  A 220 ( 4.3A)
None
None
 0.91A 1hxbB-1zipA:
undetectable		 1hxbB-1zipA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drm ACANTHAMOEBA MYOSIN
IB

(Acanthamoeba) 		PF00018
(SH3_1) 		4 GLY A  38
ASP A  35
GLY A  49
THR A  17
 None
 0.98A 1hxbB-2drmA:
undetectable		 1hxbB-2drmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Escherichia
coli) 		PF01039
(Carboxyl_trans) 		4 GLY B 135
ASP B 106
GLY B 131
THR B 202
 None
 0.99A 1hxbB-2f9yB:
undetectable		 1hxbB-2f9yB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 GLY A 308
ASP A 329
GLY A 350
THR A 374
 1PE  A1262 ( 3.9A)
None
None
None
 1.05A 1hxbB-2fafA:
undetectable		 1hxbB-2fafA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2php UNCHARACTERIZED
PROTEIN MJ0236

(Methanocaldococcus
jannaschii) 		PF10120
(ThiP_synth) 		4 GLY A 400
ASP A 382
GLY A 379
THR A 370
 None
 1.08A 1hxbB-2phpA:
undetectable		 1hxbB-2phpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		4 GLY A  42
ASP A 285
GLY A 100
THR A 109
 None
 1.09A 1hxbB-2q14A:
undetectable		 1hxbB-2q14A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 GLY A 320
ASP A 316
GLY A 118
THR A 122
 None
 1.04A 1hxbB-2qt3A:
undetectable		 1hxbB-2qt3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rij PUTATIVE
2,3,4,5-TETRAHYDROPY
RIDINE-2-CARBOXYLATE
N-
SUCCINYLTRANSFERASE

(Campylobacter
jejuni) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		4 GLY A 267
ASP A 310
GLY A 355
THR A 304
 None
 0.96A 1hxbB-2rijA:
undetectable		 1hxbB-2rijA:
15.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 GLY A  27
ASP A  29
GLY A  48
THR A  80
 AB1  A 501 (-3.9A)
AB1  A 501 ( 3.3A)
AB1  A 501 (-4.2A)
None
 0.23A 1hxbB-2rkfA:
21.1		 1hxbB-2rkfA:
86.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl7 XPD

(Sulfurisphaera
tokodaii) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		4 GLY A  75
ASP A 146
GLY A  47
THR A  40
 None
None
None
PO4  A1541 ( 4.8A)
 0.81A 1hxbB-2vl7A:
undetectable		 1hxbB-2vl7A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 GLY A 292
ASP A 222
GLY A 210
THR A 216
 None
None
None
PP6  A 327 (-3.6A)
 0.96A 1hxbB-2wedA:
7.8		 1hxbB-2wedA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1) 		4 GLY A2455
ASP A2383
GLY A2403
THR A2447
 CA  A5002 (-3.5A)
CA  A5003 ( 2.7A)
None
None
 0.95A 1hxbB-2wjsA:
undetectable		 1hxbB-2wjsA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wla DPS-LIKE PEROXIDE
RESISTANCE PROTEIN

(Streptococcus
pyogenes) 		PF00210
(Ferritin) 		4 GLY A 143
ASP A 140
GLY A 135
THR A  14
 None
 0.96A 1hxbB-2wlaA:
undetectable		 1hxbB-2wlaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x27 OUTER MEMBRANE
PROTEIN OPRG

(Pseudomonas
aeruginosa) 		PF03922
(OmpW) 		4 GLY X   4
ASP X  58
GLY X   8
THR X  53
 None
 1.06A 1hxbB-2x27X:
undetectable		 1hxbB-2x27X:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 107
ASP A 117
GLY A 120
THR A  68
 None
None
HDD  A 690 (-3.5A)
None
 0.83A 1hxbB-2xf2A:
undetectable		 1hxbB-2xf2A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgw PEROXIDE RESISTANCE
PROTEIN

(Streptococcus
pyogenes) 		PF00210
(Ferritin) 		4 GLY A 143
ASP A 140
GLY A 135
THR A  14
 None
 1.00A 1hxbB-2xgwA:
undetectable		 1hxbB-2xgwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLY A 176
ASP A 174
GLY A 270
THR A  70
 None
 0.96A 1hxbB-2z1uA:
undetectable		 1hxbB-2z1uA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A

(Sulfolobus
shibatae) 		PF04406
(TP6A_N) 		4 GLY A 296
ASP A 386
GLY A 304
THR A 352
 None
 1.06A 1hxbB-2zbkA:
undetectable		 1hxbB-2zbkA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 GLY A  85
ASP A   7
GLY A 122
THR A 126
 None
 0.92A 1hxbB-3b8lA:
undetectable		 1hxbB-3b8lA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 261
ASP A  83
GLY A 407
THR A 311
 None
 0.97A 1hxbB-3b96A:
undetectable		 1hxbB-3b96A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjp PREDICTED
AMIDOHYDROLASE,
DIHYDROOROTASE
FAMILY

(Clostridium
acetobutylicum) 		PF04909
(Amidohydro_2) 		4 GLY A  26
ASP A  28
GLY A 255
THR A 226
 None
 1.05A 1hxbB-3cjpA:
undetectable		 1hxbB-3cjpA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 GLY A  41
ASP A  20
GLY A 391
THR A 384
 None
 0.89A 1hxbB-3da1A:
undetectable		 1hxbB-3da1A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		4 GLY A 265
ASP A 260
GLY A 303
THR A 230
 None
 1.06A 1hxbB-3dhuA:
undetectable		 1hxbB-3dhuA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl0 ADENYLATE KINASE

(Bacillus
subtilis) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 GLY A  32
ASP A  84
GLY A   7
THR A  89
 AP5  A 218 (-3.5A)
MG  A 220 ( 4.3A)
None
None
 0.95A 1hxbB-3dl0A:
undetectable		 1hxbB-3dl0A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 GLY A 518
ASP A 509
GLY A 600
THR A 559
 None
None
ZN  A 756 (-4.5A)
None
 0.89A 1hxbB-3eqnA:
undetectable		 1hxbB-3eqnA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5d PROTEIN YDEA

(Bacillus
subtilis) 		PF01965
(DJ-1_PfpI) 		4 GLY A  71
ASP A  73
GLY A  47
THR A  51
 None
 1.00A 1hxbB-3f5dA:
undetectable		 1hxbB-3f5dA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		4 GLY A 346
ASP A 338
GLY A 322
THR A 318
 None
EDO  A 390 ( 4.5A)
EDO  A 388 (-4.2A)
EDO  A 388 (-4.6A)
 0.91A 1hxbB-3fdbA:
undetectable		 1hxbB-3fdbA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 GLY A 387
ASP A 385
GLY A 380
THR A 336
 None
 1.07A 1hxbB-3gzyA:
undetectable		 1hxbB-3gzyA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE

(Methanothermobacter
thermautotrophicus) 		PF00696
(AA_kinase) 		4 GLY A 219
ASP A 158
GLY A 176
THR A 260
 ADP  A 267 (-3.4A)
ADP  A 267 ( 4.4A)
None
None
 0.87A 1hxbB-3ll9A:
undetectable		 1hxbB-3ll9A:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 GLY A  27
ASP A  29
GLY A  48
THR A  80
 None
 0.31A 1hxbB-3mwsA:
19.6		 1hxbB-3mwsA:
77.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot4 PUTATIVE
ISOCHORISMATASE

(Bordetella
bronchiseptica) 		PF00857
(Isochorismatase) 		4 GLY A  43
ASP A 174
GLY A 144
THR A  51
 None
 0.97A 1hxbB-3ot4A:
undetectable		 1hxbB-3ot4A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sul CERATO-PLATANIN-LIKE
PROTEIN

(Moniliophthora
perniciosa) 		PF07249
(Cerato-platanin) 		4 GLY A  67
ASP A  94
GLY A  33
THR A  46
 None
 0.95A 1hxbB-3sulA:
undetectable		 1hxbB-3sulA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 GLY A  27
ASP A  29
GLY A  49
THR A  80
 017  A 201 (-3.4A)
017  A 201 (-3.5A)
017  A 201 (-4.0A)
None
 1.00A 1hxbB-3t3cA:
18.6		 1hxbB-3t3cA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 GLY A  27
ASP A  29
GLY A  48
THR A  80
 017  A 201 (-3.6A)
017  A 201 (-3.3A)
None
None
 0.29A 1hxbB-3ttpA:
19.7		 1hxbB-3ttpA:
78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 GLY A  27
ASP A  29
GLY A  48
THR A  80
 017  A 201 ( 3.5A)
017  A 201 (-3.2A)
017  A 202 ( 4.6A)
None
 0.34A 1hxbB-3u7sA:
20.0		 1hxbB-3u7sA:
78.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiw GLYCOSYL HYDROLASE
FAMILY 88

(Pedobacter
heparinus) 		PF07470
(Glyco_hydro_88) 		4 GLY A 362
ASP A 305
GLY A 247
THR A 234
 None
 0.67A 1hxbB-3wiwA:
undetectable		 1hxbB-3wiwA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze6 PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY A 237
ASP A 235
GLY A 231
THR A 227
 None
 1.03A 1hxbB-3ze6A:
undetectable		 1hxbB-3ze6A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b62 TSSL1

(Pseudomonas
aeruginosa) 		PF00691
(OmpA) 		4 GLY A 432
ASP A 376
GLY A 336
THR A 333
 None
 0.93A 1hxbB-4b62A:
undetectable		 1hxbB-4b62A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f82 THIOREDOXIN
REDUCTASE

(Burkholderia
cenocepacia) 		PF08534
(Redoxin) 		4 GLY A  74
ASP A  76
GLY A 140
THR A 145
 None
 1.07A 1hxbB-4f82A:
undetectable		 1hxbB-4f82A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE

(Oenococcus oeni) 		PF00465
(Fe-ADH) 		4 GLY A 108
ASP A 106
GLY A 147
THR A 142
 None
 1.00A 1hxbB-4fr2A:
undetectable		 1hxbB-4fr2A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9n AGGLUTININ

(Rhizoctonia
solani) 		PF14200
(RicinB_lectin_2) 		4 GLY A  26
ASP A  22
GLY A  41
THR A   9
 None
NGA  A 201 (-2.8A)
None
None
 1.10A 1hxbB-4g9nA:
undetectable		 1hxbB-4g9nA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 GLY A 683
ASP A 649
GLY A 657
THR A  43
 None
 0.74A 1hxbB-4hvtA:
undetectable		 1hxbB-4hvtA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ici PUTATIVE
FLAVOPROTEIN

(Bacteroides
eggerthii) 		PF12682
(Flavodoxin_4) 		4 GLY A 151
ASP A 119
GLY A 146
THR A  46
 None
None
FMN  A 200 (-3.3A)
FMN  A 200 (-3.6A)
 0.82A 1hxbB-4iciA:
undetectable		 1hxbB-4iciA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilk STARVATION SENSING
PROTEIN RSPB

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 259
ASP A 234
GLY A 168
THR A 175
 None
None
NAI  A 401 (-3.5A)
None
 1.09A 1hxbB-4ilkA:
undetectable		 1hxbB-4ilkA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00245
(Alk_phosphatase) 		4 GLY A 318
ASP A 316
GLY A  41
THR A 147
 None
 1.06A 1hxbB-4kjdA:
undetectable		 1hxbB-4kjdA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		4 GLY A 190
ASP A 150
GLY A 428
THR A 215
 None
GLN  A 501 ( 4.7A)
None
None
 1.07A 1hxbB-4n0iA:
undetectable		 1hxbB-4n0iA:
12.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 GLY A  27
ASP A  29
GLY A  48
THR A  80
 RIT  A 500 (-3.9A)
RIT  A 500 (-3.2A)
RIT  A 500 (-4.8A)
None
 0.34A 1hxbB-4njvA:
20.4		 1hxbB-4njvA:
86.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		4 GLY A  62
ASP A  59
GLY A  29
THR A  33
 None
 0.90A 1hxbB-4o8uA:
undetectable		 1hxbB-4o8uA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A 313
ASP A 282
GLY A 309
THR A  41
 None
 1.05A 1hxbB-4q05A:
undetectable		 1hxbB-4q05A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpw GLYCOSYL HYDROLASE
FAMILY 10

(Bacteroides
intestinalis) 		no annotation 4 GLY A 196
ASP A 193
GLY A 190
THR A 289
 None
 0.90A 1hxbB-4qpwA:
undetectable		 1hxbB-4qpwA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Ochrobactrum
anthropi) 		PF01547
(SBP_bac_1) 		4 GLY A  69
ASP A 251
GLY A 191
THR A 198
 None
 0.61A 1hxbB-4r2bA:
undetectable		 1hxbB-4r2bA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpa PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 GLY A 275
ASP A 272
GLY A 268
THR A 214
 None
 1.00A 1hxbB-4rpaA:
undetectable		 1hxbB-4rpaA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sviceus) 		PF00977
(His_biosynth) 		4 GLY A  27
ASP A  15
GLY A  86
THR A  64
 None
None
PO4  A 302 (-3.5A)
None
 1.05A 1hxbB-4u28A:
undetectable		 1hxbB-4u28A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		4 GLY A 925
ASP A 922
GLY A 285
THR A 280
 None
 0.85A 1hxbB-4u48A:
undetectable		 1hxbB-4u48A:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 GLY A 525
ASP A 522
GLY A 518
THR A 502
 POL  A 707 (-3.7A)
POL  A 707 ( 4.7A)
None
None
 1.01A 1hxbB-4uzsA:
undetectable		 1hxbB-4uzsA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6v DI-/TRIPEPTIDE
TRANSPORTER

(Yersinia
enterocolitica) 		PF00854
(PTR2) 		4 GLY A  88
ASP A  84
GLY A  79
THR A 236
 None
 0.89A 1hxbB-4w6vA:
undetectable		 1hxbB-4w6vA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A  28
ASP A 183
GLY A 156
THR A 113
 None
 1.03A 1hxbB-4xeuA:
undetectable		 1hxbB-4xeuA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yiv APICAL MEMBRANE
ANTIGEN AMA1

(Toxoplasma
gondii) 		PF02430
(AMA-1) 		4 GLY A 297
ASP A 392
GLY A 302
THR A 457
 None
 1.05A 1hxbB-4yivA:
undetectable		 1hxbB-4yivA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		4 GLY A 693
ASP A 683
GLY A 687
THR A 718
 None
 1.02A 1hxbB-4yu5A:
undetectable		 1hxbB-4yu5A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I, RESTRICTION
SUBUNIT

(Escherichia
coli) 		PF04851
(ResIII) 		4 GLY C 259
ASP C  81
GLY C 253
THR C 268
 None
 0.96A 1hxbB-4zcfC:
undetectable		 1hxbB-4zcfC:
8.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b18 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 GLY A  27
ASP A  29
GLY A  48
THR A  80
 None
 0.46A 1hxbB-5b18A:
18.1		 1hxbB-5b18A:
75.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		4 GLY A  98
ASP A  95
GLY A  45
THR A  64
 None
SAH  A 301 (-3.3A)
SAH  A 301 (-3.6A)
None
 0.64A 1hxbB-5bp7A:
undetectable		 1hxbB-5bp7A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 162
ASP A 188
GLY A 158
THR A 364
 None
 0.96A 1hxbB-5c2cA:
undetectable		 1hxbB-5c2cA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER

(Pseudomonas
putida) 		PF01547
(SBP_bac_1) 		4 GLY A  66
ASP A 249
GLY A 188
THR A 195
 None
 0.58A 1hxbB-5dvjA:
undetectable		 1hxbB-5dvjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		4 GLY A  97
ASP A  94
GLY A  44
THR A  63
 None
SAH  A 301 (-3.5A)
SAH  A 301 (-3.6A)
None
 0.62A 1hxbB-5epeA:
undetectable		 1hxbB-5epeA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1n BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN

(Canis lupus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLY B  56
ASP B  85
GLY A 120
THR A  10
 None
 1.06A 1hxbB-5f1nB:
undetectable		 1hxbB-5f1nB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3z ADENYLATE KINSE

(synthetic
construct) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 GLY A  32
ASP A  84
GLY A   7
THR A  89
 AP5  A1217 (-3.6A)
MG  A1218 ( 4.4A)
None
None
 0.91A 1hxbB-5g3zA:
undetectable		 1hxbB-5g3zA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 163
ASP A 189
GLY A 159
THR A 365
 None
 1.00A 1hxbB-5hqlA:
undetectable		 1hxbB-5hqlA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		4 GLY A 279
ASP A 268
GLY A 274
THR A  49
 None
 1.07A 1hxbB-5jrjA:
undetectable		 1hxbB-5jrjA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY A 237
ASP A 235
GLY A 231
THR A 227
 None
 1.02A 1hxbB-5jsyA:
undetectable		 1hxbB-5jsyA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 4 GLY B 961
ASP B 808
GLY B 965
THR B 988
 None
 1.02A 1hxbB-5kdjB:
undetectable		 1hxbB-5kdjB:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		4 GLY A2453
ASP A2428
GLY A2424
THR A2503
 None
 1.04A 1hxbB-5lkiA:
undetectable		 1hxbB-5lkiA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf2 MINOR FIMBRIUM
SUBUNIT MFA1

(Porphyromonas
gingivalis) 		no annotation 4 GLY A 527
ASP A 524
GLY A 427
THR A 440
 None
 1.08A 1hxbB-5nf2A:
undetectable		 1hxbB-5nf2A:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 GLY A 346
ASP A 416
GLY A 108
THR A 112
 None
DIO  A 618 (-3.8A)
FAD  A 601 (-3.3A)
None
 1.07A 1hxbB-5nitA:
undetectable		 1hxbB-5nitA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN

(Thermus
aquaticus) 		PF03781
(FGE-sulfatase) 		4 GLY A 137
ASP A 193
GLY A 190
THR A 124
 None
 0.91A 1hxbB-5vf4A:
undetectable		 1hxbB-5vf4A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 GLY B  87
ASP B  32
GLY B  99
THR B  12
 None
None
ZN  B 601 ( 4.2A)
None
 1.06A 1hxbB-5wwpB:
undetectable		 1hxbB-5wwpB:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmm BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
ALPHA CHAIN

(Felis catus) 		no annotation 4 GLY B  30
ASP B  59
GLY A 121
THR A  11
 None
 1.09A 1hxbB-5xmmB:
undetectable		 1hxbB-5xmmB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLY B 395
ASP B 691
GLY B 624
THR B 491
 None
 0.99A 1hxbB-5xogB:
undetectable		 1hxbB-5xogB:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 4 GLY A 149
ASP A 162
GLY A 360
THR A 245
 FAD  A 600 (-3.6A)
None
None
None
 1.08A 1hxbB-6fydA:
undetectable		 1hxbB-6fydA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2) 		PF00077
(RVP) 		4 GLY A  27
ASP A  29
GLY A  48
THR A  80
 NIU  A 100 (-4.5A)
None
None
None
 0.62A 1hxbB-6upjA:
18.0		 1hxbB-6upjA:
48.48