SIMILAR PATTERNS OF AMINO ACIDS FOR 1HWI_D_115D3

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 HIS A 132
ASN A 161
ALA A 188
LEU A 183
 None
 1.05A 1hwiC-1k1bA:
undetectable		 1hwiC-1k1bA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 HIS A 202
ASN A 231
ALA A 258
LEU A 253
 None
 0.92A 1hwiC-1k1bA:
undetectable		 1hwiC-1k1bA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLU A 112
HIS A 105
LEU A 212
LEU A 216
 None
 0.81A 1hwiC-1kfiA:
4.2		 1hwiC-1kfiA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aeropyrum
pernix) 		PF01791
(DeoC) 		4 CYH A  76
LEU A  99
ALA A 130
LEU A 129
 None
 1.01A 1hwiC-1n7kA:
undetectable		 1hwiC-1n7kA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 HIS D  63
ASN D  91
ALA D 118
LEU D 113
 None
 0.93A 1hwiC-1oy3D:
undetectable		 1hwiC-1oy3D:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 ASN A 260
LEU A 241
ALA A 245
LEU A 246
 None
 0.74A 1hwiC-1oznA:
undetectable		 1hwiC-1oznA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		4 GLU A  83
ASN A 271
ALA A 371
LEU A 372
 HMG  A1002 ( 3.4A)
HMG  A1002 (-3.9A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.42A 1hwiC-1qaxA:
28.1		 1hwiC-1qaxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 CYH A 267
LEU A 390
ALA A 393
LEU A 343
 None
 1.04A 1hwiC-1vljA:
undetectable		 1hwiC-1vljA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		5 CYH A  99
ASN A 128
LEU A  87
ALA A  90
LEU A  91
 None
 0.84A 1hwiC-1ydoA:
undetectable		 1hwiC-1ydoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN
ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		4 GLU U 387
LEU E 340
ALA E 258
LEU E 259
 PO4  U   1 (-3.6A)
None
None
None
 0.85A 1hwiC-1z5xU:
undetectable		 1hwiC-1z5xU:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a11 RIBONUCLEASE III

(Mycobacterium
tuberculosis) 		PF14622
(Ribonucleas_3_3) 		4 HIS A  99
LEU A   8
ALA A  11
LEU A  12
 None
 0.68A 1hwiC-2a11A:
undetectable		 1hwiC-2a11A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT

(Homo sapiens) 		PF01012
(ETF) 		4 GLU B  48
LEU B 160
ALA B 179
LEU B 177
 None
 0.92A 1hwiC-2a1uB:
undetectable		 1hwiC-2a1uB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 CYH A 446
LEU A 531
ALA A 527
LEU A 530
 None
 0.98A 1hwiC-2a7sA:
undetectable		 1hwiC-2a7sA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		4 GLU A 132
LEU A 139
ALA A 142
LEU A 143
 None
 0.78A 1hwiC-2bbzA:
undetectable		 1hwiC-2bbzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5s PROBABLE THIAMINE
BIOSYNTHESIS PROTEIN
THII

(Bacillus
anthracis) 		PF02568
(ThiI)
PF02926
(THUMP) 		4 GLU A 217
HIS A 210
LEU A 241
LEU A 239
 None
 0.69A 1hwiC-2c5sA:
3.6		 1hwiC-2c5sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4p HYPOTHETICAL PROTEIN
TTHA1254

(Thermus
thermophilus) 		PF09390
(DUF1999) 		4 GLU A  69
LEU A 106
ALA A 109
LEU A 110
 None
 0.70A 1hwiC-2d4pA:
undetectable		 1hwiC-2d4pA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASN A 232
LEU A 244
ALA A 247
LEU A 248
 None
 1.06A 1hwiC-2g76A:
undetectable		 1hwiC-2g76A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q12 DCC-INTERACTING
PROTEIN 13 ALPHA

(Homo sapiens) 		PF16746
(BAR_3) 		4 GLU A  95
ASN A 217
LEU A 222
LEU A 226
 None
 0.91A 1hwiC-2q12A:
undetectable		 1hwiC-2q12A:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		8 GLU A 559
CYH A 561
LYS A 735
HIS A 752
ASN A 755
LEU A 853
ALA A 856
LEU A 857
 None
 0.20A 1hwiC-2r4fA:
40.5		 1hwiC-2r4fA:
95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 HIS A 211
LEU A 206
ALA A  93
LEU A  74
 None
 1.01A 1hwiC-2vobA:
undetectable		 1hwiC-2vobA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyr COBALT-ACTIVATED
PEPTIDASE TET1

(Pyrococcus
horikoshii) 		PF05343
(Peptidase_M42) 		4 GLU A 330
ASN A 271
LEU A 323
LEU A 298
 None
 1.00A 1hwiC-2wyrA:
undetectable		 1hwiC-2wyrA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8v CLASS III CHITINASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 GLU A  75
HIS A  17
LEU A  20
LEU A  59
 None
 0.96A 1hwiC-2y8vA:
undetectable		 1hwiC-2y8vA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 ASN A2175
LEU A2170
ALA A2192
LEU A2168
 None
 0.78A 1hwiC-2ypdA:
undetectable		 1hwiC-2ypdA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		4 HIS A 276
LEU A 386
ALA A 385
LEU A 320
 None
 0.83A 1hwiC-3aczA:
undetectable		 1hwiC-3aczA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 GLU B 214
ASN B 314
LEU B 321
ALA B 324
 None
 0.97A 1hwiC-3aeqB:
undetectable		 1hwiC-3aeqB:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay3 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Chromohalobacter
salexigens) 		PF01370
(Epimerase) 		4 CYH A  49
HIS A  69
LEU A  93
ALA A  96
 None
 0.88A 1hwiC-3ay3A:
undetectable		 1hwiC-3ay3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e10 PUTATIVE NADH
OXIDASE

(Clostridium
acetobutylicum) 		PF00881
(Nitroreductase) 		4 CYH A 139
LEU A  56
ALA A  72
LEU A  47
 None
EDO  A 503 (-4.2A)
None
None
 1.02A 1hwiC-3e10A:
4.6		 1hwiC-3e10A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 ASN A 157
LEU A 115
ALA A 111
LEU A 114
 None
 1.00A 1hwiC-3fahA:
undetectable		 1hwiC-3fahA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		4 ASN A 206
LEU A 231
ALA A 255
LEU A 228
 None
 0.83A 1hwiC-3j0aA:
undetectable		 1hwiC-3j0aA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6h NITROREDUCTASE
FAMILY PROTEIN

(Agrobacterium
fabrum) 		PF00881
(Nitroreductase) 		4 GLU A  87
LEU A  71
ALA A  74
LEU A  75
 None
 0.66A 1hwiC-3k6hA:
4.6		 1hwiC-3k6hA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 ASN E 257
LEU E 265
ALA E 268
LEU E 269
 None
 0.78A 1hwiC-3kfuE:
undetectable		 1hwiC-3kfuE:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)

(Clostridium
acetobutylicum) 		PF07992
(Pyr_redox_2) 		4 ASN A 377
LEU A 379
ALA A 359
LEU A 356
 None
 0.86A 1hwiC-3kljA:
undetectable		 1hwiC-3kljA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 ASN A 372
LEU A 435
ALA A 438
LEU A 439
 None
 0.67A 1hwiC-3kv6A:
undetectable		 1hwiC-3kv6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		4 GLU A 207
LEU A 258
ALA A 257
LEU A 266
 None
 0.93A 1hwiC-3ky9A:
undetectable		 1hwiC-3ky9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		4 CYH B  76
LEU B  11
ALA B  14
LEU B  15
 None
 0.80A 1hwiC-3l4gB:
3.7		 1hwiC-3l4gB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		4 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.70A 1hwiC-3mwtA:
undetectable		 1hwiC-3mwtA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		4 ASN A 481
LEU A 183
ALA A 186
LEU A 187
 None
 0.97A 1hwiC-3o6xA:
undetectable		 1hwiC-3o6xA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osj PHYCOBILISOME LCM
CORE-MEMBRANE LINKER
POLYPEPTIDE

(Synechocystis
sp. PCC 6803) 		PF00427
(PBS_linker_poly) 		4 ASN A 339
LEU A 376
ALA A 379
LEU A 380
 None
 0.96A 1hwiC-3osjA:
undetectable		 1hwiC-3osjA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		4 CYH A 355
HIS A  98
LEU A  90
LEU A 236
 HEM  A 501 (-2.4A)
HEM  A 501 ( 3.8A)
HEM  A 501 (-4.2A)
None
 0.87A 1hwiC-3p3lA:
undetectable		 1hwiC-3p3lA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 ASN A 909
LEU A 916
ALA A 919
LEU A 920
 None
 0.57A 1hwiC-3psfA:
undetectable		 1hwiC-3psfA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7b NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF17290
(Arena_ncap_C) 		4 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.89A 1hwiC-3q7bA:
undetectable		 1hwiC-3q7bA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)

(Mycobacterium
ulcerans) 		PF01053
(Cys_Met_Meta_PP) 		4 HIS A 279
LEU A 387
ALA A 386
LEU A 324
 None
 0.89A 1hwiC-3qi6A:
undetectable		 1hwiC-3qi6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ASN A 272
LEU A  23
ALA A  26
LEU A  27
 None
 0.61A 1hwiC-3qlvA:
undetectable		 1hwiC-3qlvA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLU A 271
LEU A  23
ALA A  26
LEU A  27
 None
 0.99A 1hwiC-3qlvA:
undetectable		 1hwiC-3qlvA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw4 UMP SYNTHASE

(Leishmania
donovani) 		PF00156
(Pribosyltran)
PF00215
(OMPdecase) 		4 ASN B  51
LEU B  81
ALA B  99
LEU B 103
 U5P  B7485 (-3.3A)
None
None
None
 0.88A 1hwiC-3qw4B:
undetectable		 1hwiC-3qw4B:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		4 HIS A 140
LEU A  20
ALA A  23
LEU A  24
 None
 0.63A 1hwiC-3uykA:
undetectable		 1hwiC-3uykA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 4 GLU A 270
LEU A 419
ALA A 422
LEU A 423
 None
 0.91A 1hwiC-3wvrA:
2.4		 1hwiC-3wvrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 GLU A  12
ASN A 210
ALA A  19
LEU A 202
 None
 0.86A 1hwiC-4a01A:
undetectable		 1hwiC-4a01A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		4 HIS A 353
ASN A 202
ALA A  51
LEU A  54
 None
 0.72A 1hwiC-4au2A:
undetectable		 1hwiC-4au2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 GLU A 556
LEU A 639
ALA A 642
LEU A 643
 None
 0.90A 1hwiC-4ay2A:
undetectable		 1hwiC-4ay2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9

(Homo sapiens) 		PF11979
(DUF3480) 		4 CYH A1348
LEU A1392
ALA A1395
LEU A1396
 None
 0.77A 1hwiC-4bkwA:
undetectable		 1hwiC-4bkwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4

(Schizosaccharomyces
pombe) 		PF00533
(BRCT)
PF16589
(BRCT_2) 		4 ASN A 440
LEU A 415
ALA A 418
LEU A 419
 None
 0.98A 1hwiC-4bmdA:
undetectable		 1hwiC-4bmdA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 GLU B 107
LEU B 100
ALA B 160
LEU B  98
 None
 0.89A 1hwiC-4ci2B:
undetectable		 1hwiC-4ci2B:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em2 UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349

(Staphylococcus
aureus) 		PF01047
(MarR) 		4 CYH A 142
HIS A  66
LEU A 137
LEU A 113
 None
 0.94A 1hwiC-4em2A:
undetectable		 1hwiC-4em2A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 HIS A 519
LEU A 528
ALA A 531
LEU A 532
 None
 0.94A 1hwiC-4f7zA:
undetectable		 1hwiC-4f7zA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 GLU B 881
LEU B 847
ALA B 846
LEU B 850
 None
 1.00A 1hwiC-4fhnB:
undetectable		 1hwiC-4fhnB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 925
LEU A 937
ALA A 940
LEU A 941
 None
 0.85A 1hwiC-4fysA:
undetectable		 1hwiC-4fysA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9z NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF17290
(Arena_ncap_C) 		4 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.93A 1hwiC-4g9zA:
undetectable		 1hwiC-4g9zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 HIS A 354
LEU A 242
ALA A 245
LEU A 246
 None
 0.98A 1hwiC-4ictA:
1.9		 1hwiC-4ictA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ASN A 243
LEU A 264
ALA A 324
LEU A 325
 None
 1.05A 1hwiC-4iglA:
undetectable		 1hwiC-4iglA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ASN A 172
LEU A 197
ALA A 242
LEU A 239
 LLP  A 196 ( 3.9A)
LLP  A 196 ( 3.7A)
None
None
 0.97A 1hwiC-4j8lA:
undetectable		 1hwiC-4j8lA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		4 ASN A 613
LEU A 595
ALA A 598
LEU A 599
 None
 0.59A 1hwiC-4k17A:
undetectable		 1hwiC-4k17A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		4 GLU A 144
HIS A 155
LEU A 160
LEU A 162
 None
 0.91A 1hwiC-4kfvA:
undetectable		 1hwiC-4kfvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN

(Homo sapiens) 		PF15009
(TMEM173) 		4 GLU A 296
LEU A 202
ALA A 262
LEU A 265
 None
 1.00A 1hwiC-4ksyA:
undetectable		 1hwiC-4ksyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk5 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 ASN A 225
LEU A 232
ALA A 235
LEU A 236
 None
 0.60A 1hwiC-4lk5A:
undetectable		 1hwiC-4lk5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE

(Toxoplasma
gondii) 		PF00834
(Ribul_P_3_epim) 		4 GLU A  97
LEU A 133
ALA A 136
LEU A 137
 None
 0.64A 1hwiC-4nu7A:
undetectable		 1hwiC-4nu7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ

(Pseudomonas
putida) 		PF16822
(ALGX) 		4 ASN A 311
LEU A 301
ALA A 202
LEU A 205
 None
 0.98A 1hwiC-4o8vA:
undetectable		 1hwiC-4o8vA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		4 ASN A 261
LEU A 242
ALA A 246
LEU A 247
 None
 0.82A 1hwiC-4p8sA:
undetectable		 1hwiC-4p8sA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw8 TRYPTOPHAN
2,3-DIOXYGENASE

(Homo sapiens) 		PF03301
(Trp_dioxygenase) 		4 HIS A 273
LEU A 289
ALA A 292
LEU A 293
 None
 0.65A 1hwiC-4pw8A:
undetectable		 1hwiC-4pw8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 CYH A  51
LEU A 206
ALA A 209
LEU A 210
 None
 0.96A 1hwiC-4q2cA:
undetectable		 1hwiC-4q2cA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		4 GLU A 342
ASN A 171
LEU A 175
LEU A 179
 None
 0.81A 1hwiC-4r27A:
undetectable		 1hwiC-4r27A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xky DIHYDRODIPICOLINATE
SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00701
(DHDPS) 		4 GLU A 193
LEU A 262
ALA A 265
LEU A 266
 None
 0.64A 1hwiC-4xkyA:
undetectable		 1hwiC-4xkyA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 HIS A 285
LEU A 110
ALA A 113
LEU A 114
 None
 0.90A 1hwiC-4xwtA:
undetectable		 1hwiC-4xwtA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 GLU A 403
LEU A 291
ALA A 294
LEU A 295
 None
 0.84A 1hwiC-4zi6A:
undetectable		 1hwiC-4zi6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3g PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		4 ASN B 356
LEU B 272
ALA B 275
LEU B 276
 None
 1.06A 1hwiC-5b3gB:
undetectable		 1hwiC-5b3gB:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		4 ASN B 356
LEU B 272
ALA B 275
LEU B 276
 None
 0.95A 1hwiC-5b3hB:
undetectable		 1hwiC-5b3hB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		4 CYH A 403
LEU A 466
ALA A 469
LEU A 470
 None
 0.97A 1hwiC-5cbmA:
undetectable		 1hwiC-5cbmA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 ASN A 390
LEU A 452
ALA A 455
LEU A 456
 None
 0.69A 1hwiC-5dqfA:
undetectable		 1hwiC-5dqfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 GLU A 279
LEU A 227
ALA A 194
LEU A 190
 None
 0.84A 1hwiC-5e8hA:
undetectable		 1hwiC-5e8hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		4 GLU C1350
LEU C1050
ALA C1056
LEU C1048
 None
 0.97A 1hwiC-5exrC:
4.9		 1hwiC-5exrC:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		4 GLU B  75
ASN B  78
LEU B  45
LEU B  41
 None
 0.97A 1hwiC-5ey5B:
undetectable		 1hwiC-5ey5B:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 HIS A 270
ASN A 274
LEU A 315
LEU A 311
 None
 0.60A 1hwiC-5fbzA:
undetectable		 1hwiC-5fbzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 ASN A2175
LEU A2170
ALA A2192
LEU A2168
 None
 0.74A 1hwiC-5fzoA:
undetectable		 1hwiC-5fzoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED

(Oryza sativa) 		PF03514
(GRAS) 		4 ASN A 409
LEU A 330
ALA A 333
LEU A 334
 None
 0.96A 1hwiC-5hyzA:
undetectable		 1hwiC-5hyzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 140
LEU A  57
ALA A  77
LEU A  67
 IDV  A 401 ( 4.5A)
IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
 1.04A 1hwiC-5i3oA:
2.7		 1hwiC-5i3oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 GLU A 681
LEU A 695
ALA A 628
LEU A 631
 None
 0.99A 1hwiC-5jjhA:
undetectable		 1hwiC-5jjhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00291
(PALP) 		4 GLU B  82
ASN B  85
LEU B  52
LEU B  48
 None
 1.01A 1hwiC-5kinB:
undetectable		 1hwiC-5kinB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 ASN A 540
LEU A 408
ALA A 411
LEU A 412
 None
 1.06A 1hwiC-5l3dA:
undetectable		 1hwiC-5l3dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		4 GLU M 335
ASN M 331
LEU M 436
ALA M 435
 None
 0.81A 1hwiC-5lc5M:
undetectable		 1hwiC-5lc5M:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ASN A 205
LEU A 186
ALA A 190
LEU A 191
 None
 0.92A 1hwiC-5lfnA:
undetectable		 1hwiC-5lfnA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 GLU A 440
ASN A 417
LEU A 965
ALA A 961
 None
 0.87A 1hwiC-5lq3A:
6.3		 1hwiC-5lq3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		4 GLU A 288
LEU A   8
ALA A 259
LEU A 260
 None
 1.02A 1hwiC-5v2iA:
undetectable		 1hwiC-5v2iA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7

(Homo sapiens) 		PF00098
(zf-CCHC)
PF03828
(PAP_assoc) 		4 HIS A1286
LEU A1288
ALA A1172
LEU A1175
 U  H   4 ( 4.4A)
U  H   4 ( 4.5A)
None
None
 1.00A 1hwiC-5w0mA:
undetectable		 1hwiC-5w0mA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE

(Streptococcus
pneumoniae) 		no annotation 4 GLU A  81
ASN A 267
ALA A 368
LEU A 369
 HMG  A 500 (-3.8A)
HMG  A 500 (-3.8A)
HMG  A 500 ( 3.7A)
HMG  A 500 (-4.7A)
 0.39A 1hwiC-5wpkA:
28.9		 1hwiC-5wpkA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 GLU B  87
ASN B  70
ALA B  39
LEU B  40
 None
 0.67A 1hwiC-5xmjB:
undetectable		 1hwiC-5xmjB:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykh PUMILIO HOMOLOG 1

(Homo sapiens) 		no annotation 4 HIS A 133
LEU A  99
ALA A 102
LEU A 103
 None
 0.98A 1hwiC-5ykhA:
undetectable		 1hwiC-5ykhA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 4 CYH A 466
LEU A 479
ALA A 569
LEU A 481
 None
 0.90A 1hwiC-5yy3A:
undetectable		 1hwiC-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 4 ASN A 262
LEU A 260
ALA A 129
LEU A 132
 None
 1.05A 1hwiC-6b07A:
2.1		 1hwiC-6b07A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 4 HIS A 386
LEU A  92
ALA A 109
LEU A 216
 None
 0.96A 1hwiC-6et9A:
undetectable		 1hwiC-6et9A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 GLU B 175
LEU B 218
ALA B 221
LEU B 222
 None
 0.49A 1hwiC-6evjB:
1.6		 1hwiC-6evjB:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ARG B  22
VAL A 107
ASP B  27
LYS B 385
 None
 1.20A 1hwiD-1e9yB:
0.0		 1hwiD-1e9yB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 ARG A 274
ASN A 278
ASP A  38
LYS A   1
 None
 1.01A 1hwiD-1ex9A:
0.0		 1hwiD-1ex9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB
N15 ALPHA-BETA
T-CELL RECEPTOR

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL E  97
SER E  91
ASN E  95
LYS B 224
 None
 1.08A 1hwiD-1nfdE:
0.0		 1hwiD-1nfdE:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdd LITHOSTATHINE

(Homo sapiens) 		PF00059
(Lectin_C) 		4 VAL A 116
SER A 117
ASN A  75
ASP A 134
 None
 1.32A 1hwiD-1qddA:
0.0		 1hwiD-1qddA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr0 4'-PHOSPHOPANTETHEIN
YL TRANSFERASE SFP

(Bacillus
subtilis) 		PF01648
(ACPS) 		4 VAL A  95
ASN A  87
ASP A 107
LYS A 155
 None
COA  A 300 (-3.4A)
MG  A 400 ( 2.8A)
COA  A 300 (-2.8A)
 1.33A 1hwiD-1qr0A:
undetectable		 1hwiD-1qr0A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s79 LUPUS LA PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 ARG A 111
VAL A 108
ASN A 139
ASP A 159
 None
 1.31A 1hwiD-1s79A:
undetectable		 1hwiD-1s79A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgj CITRATE LYASE, BETA
SUBUNIT

(Deinococcus
radiodurans) 		PF03328
(HpcH_HpaI) 		4 ARG A  74
VAL A  98
ASN A  76
ASP A  39
 OAA  A 285 ( 2.3A)
None
None
OAA  A 285 (-4.6A)
 1.35A 1hwiD-1sgjA:
undetectable		 1hwiD-1sgjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twb STRINGENT STARVATION
PROTEIN B HOMOLOG

(Haemophilus
influenzae) 		PF04386
(SspB) 		4 ARG A  74
VAL A  78
SER A  79
ASN A  72
 None
 1.06A 1hwiD-1twbA:
undetectable		 1hwiD-1twbA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		4 ARG A 191
VAL A 190
SER A 187
ASN A 184
 None
 1.02A 1hwiD-1ur4A:
undetectable		 1hwiD-1ur4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		4 VAL A 177
SER A 174
ASN A 171
ASP A 225
 VAL  A 177 ( 0.6A)
SER  A 174 ( 0.0A)
ASN  A 171 ( 0.6A)
ASP  A 225 ( 0.6A)
 1.29A 1hwiD-1vhoA:
undetectable		 1hwiD-1vhoA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 768
SER A 778
ASN A 780
ASP A 179
 None
 1.36A 1hwiD-1xkhA:
undetectable		 1hwiD-1xkhA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 ARG A 245
SER A  97
ASN A 102
ASP A 308
 None
 1.24A 1hwiD-1xl8A:
3.4		 1hwiD-1xl8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7l UBIQUITIN-ACTIVATING
ENZYME E1 1

(Mus musculus) 		PF10585
(UBA_e1_thiolCys) 		4 ARG A 880
VAL A 863
ASN A 856
ASP A 854
 None
 1.34A 1hwiD-1z7lA:
undetectable		 1hwiD-1z7lA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab4 TRNA PSEUDOURIDINE
SYNTHASE B

(Thermotoga
maritima) 		PF01472
(PUA)
PF01509
(TruB_N)
PF16198
(TruB_C_2) 		4 VAL A  69
SER A 160
ASN A 153
ASP A 151
 None
 1.28A 1hwiD-2ab4A:
3.4		 1hwiD-2ab4A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		4 VAL A  82
SER A  83
ASN A 140
LYS A 146
 None
None
None
NAD  A 401 (-2.0A)
 1.22A 1hwiD-2c20A:
undetectable		 1hwiD-2c20A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2duy COMPETENCE PROTEIN
COMEA-RELATED
PROTEIN

(Thermus
thermophilus) 		PF12836
(HHH_3) 		4 ARG A  74
VAL A  19
SER A  20
ASN A  22
 None
 1.37A 1hwiD-2duyA:
undetectable		 1hwiD-2duyA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ARG A 300
VAL A 290
ASN A 299
ASP A 324
 None
None
None
CA  A 995 (-3.6A)
 1.33A 1hwiD-2htvA:
undetectable		 1hwiD-2htvA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nd4 AMYLASE-BINDING
PROTEIN ABPA

(Streptococcus
parasanguinis) 		no annotation 4 ARG A 136
ASN A 133
ASP A 140
LYS A 177
 None
 1.35A 1hwiD-2nd4A:
undetectable		 1hwiD-2nd4A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		4 ARG A 768
SER A 778
ASN A 780
ASP A 179
 None
 1.37A 1hwiD-2o5pA:
undetectable		 1hwiD-2o5pA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 VAL A 211
SER A 210
ASN A 246
ASP A 208
 None
 1.33A 1hwiD-2odlA:
undetectable		 1hwiD-2odlA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odv PLECTIN 1

(Homo sapiens) 		no annotation 4 ARG A 365
ASN A 364
ASP A 362
LYS A 359
 None
 1.31A 1hwiD-2odvA:
undetectable		 1hwiD-2odvA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		4 VAL A  85
SER A  84
ASP A 105
LYS A 107
 None
 1.35A 1hwiD-2q9gA:
undetectable		 1hwiD-2q9gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		4 VAL A 332
SER A 331
ASN A 328
ASP A 326
 None
 1.30A 1hwiD-2qqpA:
undetectable		 1hwiD-2qqpA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		7 ARG A 590
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
 RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
 0.30A 1hwiD-2r4fA:
40.7		 1hwiD-2r4fA:
95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsz ENGULFMENT AND CELL
MOTILITY PROTEIN 1

(Homo sapiens) 		PF16457
(PH_12) 		4 VAL A 616
SER A 643
ASN A 653
LYS A 626
 None
 1.28A 1hwiD-2vszA:
undetectable		 1hwiD-2vszA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 VAL A 211
SER A 221
ASN A 220
ASP A 218
 None
 1.29A 1hwiD-2ycbA:
2.1		 1hwiD-2ycbA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 VAL A 269
SER A 268
ASN A 316
ASP A 264
 None
 1.19A 1hwiD-3a9sA:
undetectable		 1hwiD-3a9sA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ARG A 300
VAL A 290
ASN A 299
ASP A 324
 None
None
None
CA  A   1 (-3.3A)
 1.37A 1hwiD-3ckzA:
undetectable		 1hwiD-3ckzA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 VAL A 358
SER A 357
ASN A 353
ASP A 355
 None
 1.29A 1hwiD-3cnjA:
0.0		 1hwiD-3cnjA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3c L0044

(Escherichia
coli) 		PF16518
(GrlR) 		4 ARG A  -2
VAL A  -4
SER A  81
LYS A   4
 None
 1.21A 1hwiD-3e3cA:
undetectable		 1hwiD-3e3cA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		4 SER X 273
ASN X 229
ASP X 270
LYS X 266
 None
 1.28A 1hwiD-3ewbX:
undetectable		 1hwiD-3ewbX:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez9 PARA

(Salmonella
enterica) 		PF13614
(AAA_31) 		4 ARG A 135
VAL A 136
ASP A 144
LYS A 101
 None
 1.35A 1hwiD-3ez9A:
undetectable		 1hwiD-3ez9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		4 ARG I  66
SER G  64
ASN G  65
ASP G 104
 U  C 101 ( 3.1A)
None
U  C 101 ( 3.2A)
U  C 101 ( 3.0A)
 1.15A 1hwiD-3jb9I:
undetectable		 1hwiD-3jb9I:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 ANTIBODY FAB
FRAGMENT LIGHT CHAIN

(Cricetulus
migratorius) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B 169
SER B 180
ASN B 143
ASP B 173
 None
 1.33A 1hwiD-3ld8B:
undetectable		 1hwiD-3ld8B:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 VAL A 120
SER A 117
ASN A 114
ASP A  94
 None
 1.12A 1hwiD-3mzvA:
undetectable		 1hwiD-3mzvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 SER A 573
ASN A 571
ASP A 531
LYS A 530
 None
 1.34A 1hwiD-3nowA:
undetectable		 1hwiD-3nowA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxk CYTOPLASMIC
L-ASPARAGINASE

(Campylobacter
jejuni) 		PF00710
(Asparaginase) 		4 VAL A 276
SER A 277
ASN A 303
ASP A 301
 None
 1.25A 1hwiD-3nxkA:
undetectable		 1hwiD-3nxkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi) 		PF04264
(YceI) 		4 VAL A 187
SER A  30
ASN A  27
ASP A  26
 None
None
GOL  A   3 (-4.3A)
None
 1.29A 1hwiD-3q34A:
undetectable		 1hwiD-3q34A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgm P-NITROPHENYL
PHOSPHATASE (PHO2)

(Archaeoglobus
fulgidus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 VAL A  43
SER A  44
ASN A  46
ASP A  13
 None
 1.18A 1hwiD-3qgmA:
undetectable		 1hwiD-3qgmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		4 VAL A  11
SER A  20
ASN A  26
ASP A  18
 IOD  A 175 ( 4.6A)
None
IOD  A 184 (-3.7A)
None
 1.23A 1hwiD-3s6lA:
undetectable		 1hwiD-3s6lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ARG A 608
VAL A 438
SER A 439
ASN A 473
 None
 1.21A 1hwiD-3s95A:
undetectable		 1hwiD-3s95A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 ARG A  95
VAL A  56
ASN A  92
ASP A 133
 None
 1.09A 1hwiD-3slkA:
undetectable		 1hwiD-3slkA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29) 		PF00843
(Arena_nucleocap) 		4 ARG A 221
SER A 217
ASN A 215
LYS A 212
 None
None
A  C   8 ( 4.1A)
None
 1.18A 1hwiD-3t5qA:
undetectable		 1hwiD-3t5qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ARG A 300
VAL A 290
ASN A 299
ASP A 324
 None
None
None
CA  A 601 (-3.3A)
 1.32A 1hwiD-3ti8A:
undetectable		 1hwiD-3ti8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B
ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 VAL A 710
SER A 711
ASP B 357
LYS B 356
 None
 1.28A 1hwiD-3u44A:
undetectable		 1hwiD-3u44A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw0 PECTINESTERASE

(Yersinia
enterocolitica) 		PF01095
(Pectinesterase) 		4 ARG A  75
VAL A  78
SER A  76
ASP A  54
 None
 1.28A 1hwiD-3uw0A:
undetectable		 1hwiD-3uw0A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi5 MAJOR OUTER MEMBRANE
PROTEIN P.IB

(Neisseria
meningitidis) 		PF00267
(Porin_1) 		4 VAL A 143
SER A 142
ASN A 164
ASP A 100
 None
 1.37A 1hwiD-3wi5A:
undetectable		 1hwiD-3wi5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 VAL A 111
SER A 108
ASN A 105
ASP A  85
 None
 1.06A 1hwiD-3wjoA:
2.5		 1hwiD-3wjoA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 VAL A  57
SER A  58
ASN A  60
ASP A  27
 None
None
NO3  A1305 ( 4.4A)
None
 1.36A 1hwiD-4bkmA:
undetectable		 1hwiD-4bkmA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 VAL A  57
SER A  58
ASN A  60
ASP A 175
 None
 1.27A 1hwiD-4bx0A:
undetectable		 1hwiD-4bx0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 ARG A 255
SER A 246
ASN A 253
ASP A 239
 None
 1.32A 1hwiD-4c1sA:
undetectable		 1hwiD-4c1sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		4 ARG A 177
SER A 249
ASP A 251
LYS A 254
 None
 1.16A 1hwiD-4c4aA:
undetectable		 1hwiD-4c4aA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ARG A 504
VAL A 417
ASN A 467
ASP A 465
 None
 1.30A 1hwiD-4cmnA:
undetectable		 1hwiD-4cmnA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE SUBUNIT
RPT4

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 VAL L 380
SER L 383
ASP L 390
LYS L 426
 None
 1.36A 1hwiD-4cr4L:
undetectable		 1hwiD-4cr4L:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvy DIOXYGENASE
RV3406/MT3514

(Mycobacterium
tuberculosis) 		PF02668
(TauD) 		4 ARG A 266
VAL A 267
SER A 110
ASN A 246
 None
 1.34A 1hwiD-4cvyA:
undetectable		 1hwiD-4cvyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3d IMINE REDUCTASE

(Bacillus cereus) 		PF03446
(NAD_binding_2) 		4 SER A 112
ASN A 110
ASP A 114
LYS A 118
 None
 1.25A 1hwiD-4d3dA:
undetectable		 1hwiD-4d3dA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7q RALF,
PROLINE/BETAINE
TRANSPORTER

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		4 VAL A 126
SER A 127
ASN A 171
ASP A 130
 None
None
None
PEG  A1354 (-3.5A)
 1.22A 1hwiD-4d7qA:
1.5		 1hwiD-4d7qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ec7 VENOM NERVE GROWTH
FACTOR

(Naja atra) 		PF00243
(NGF) 		4 ARG A  67
ASN A  60
ASP A  15
LYS A  57
 None
 1.33A 1hwiD-4ec7A:
undetectable		 1hwiD-4ec7A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecm GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Bacillus
anthracis) 		PF00483
(NTP_transferase) 		4 VAL A 178
SER A 176
ASN A  99
LYS A  -4
 None
 1.33A 1hwiD-4ecmA:
undetectable		 1hwiD-4ecmA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 VAL A 594
SER A 614
ASN A 611
ASP A 608
 None
 1.34A 1hwiD-4fusA:
undetectable		 1hwiD-4fusA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 VAL A 361
SER A 645
ASN A 648
ASP A 650
 None
PO4  A 801 (-2.4A)
None
PO4  A 801 (-3.4A)
 1.37A 1hwiD-4fyeA:
undetectable		 1hwiD-4fyeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ARG A 576
VAL A 575
ASP A 403
LYS A 341
 None
 1.37A 1hwiD-4i1pA:
undetectable		 1hwiD-4i1pA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 VAL A 586
SER A 584
ASN A 527
ASP A 581
 None
 1.36A 1hwiD-4j3bA:
undetectable		 1hwiD-4j3bA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5i ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Mycolicibacterium
smegmatis) 		PF02668
(TauD) 		4 ARG A 263
VAL A 264
SER A 108
ASN A 243
 None
 1.32A 1hwiD-4j5iA:
undetectable		 1hwiD-4j5iA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jug HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ARG A 212
VAL A 202
SER A 203
ASN A 210
 None
 1.28A 1hwiD-4jugA:
undetectable		 1hwiD-4jugA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		4 VAL A 111
SER A 108
ASN A 105
ASP A  85
 None
 1.08A 1hwiD-4jxyA:
undetectable		 1hwiD-4jxyA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1o CATENIN ALPHA-2

(Mus musculus) 		PF01044
(Vinculin) 		4 VAL A 856
SER A 857
ASP A 705
LYS A 861
 None
 1.33A 1hwiD-4k1oA:
undetectable		 1hwiD-4k1oA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 VAL A 322
SER A 323
ASN A 962
ASP A 325
 None
 1.00A 1hwiD-4lglA:
1.8		 1hwiD-4lglA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis) 		no annotation 4 ARG A  91
SER A 147
ASN A 149
ASP A  89
 None
 1.35A 1hwiD-4lmhA:
undetectable		 1hwiD-4lmhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ARG A 300
VAL A 290
ASN A 299
ASP A 324
 None
None
None
CA  A 502 (-3.2A)
 1.34A 1hwiD-4mjuA:
undetectable		 1hwiD-4mjuA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2

(Bdellovibrio
bacteriovorus) 		PF14566
(PTPlike_phytase) 		4 ARG A 212
VAL A 175
ASN A 123
ASP A 120
 None
 1.35A 1hwiD-4nx8A:
undetectable		 1hwiD-4nx8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqy (S)-IMINE REDUCTASE

(Streptomyces
sp. GF3546) 		PF03446
(NAD_binding_2) 		4 SER A  93
ASN A  91
ASP A  95
LYS A  99
 None
 1.34A 1hwiD-4oqyA:
undetectable		 1hwiD-4oqyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozu CORONIN

(Toxoplasma
gondii) 		PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4) 		4 ARG A 200
ASN A 137
ASP A 183
LYS A 181
 None
 1.31A 1hwiD-4ozuA:
undetectable		 1hwiD-4ozuA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		4 ARG A 343
VAL A 342
ASN A 321
LYS A 177
 None
 1.11A 1hwiD-4u4eA:
undetectable		 1hwiD-4u4eA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		4 SER B 154
ASN B 140
ASP B 190
LYS B 189
 None
 1.37A 1hwiD-4x33B:
undetectable		 1hwiD-4x33B:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi) 		PF03702
(AnmK) 		4 ARG A 388
VAL A 385
SER A 383
ASP A 206
 None
 0.96A 1hwiD-4zxzA:
undetectable		 1hwiD-4zxzA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxy RNA
METHYLTRANSFERASE

(Salinibacter
ruber) 		PF13847
(Methyltransf_31) 		4 VAL A 120
SER A 121
ASN A 102
ASP A 123
 None
 1.05A 1hwiD-5bxyA:
undetectable		 1hwiD-5bxyA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwf PEPTIDOGLYCAN
RECOGNITION PROTEIN
1

(Camelus
dromedarius) 		PF01510
(Amidase_2) 		4 ARG A  62
VAL A  61
SER A  58
ASN A  55
 None
 1.06A 1hwiD-5dwfA:
undetectable		 1hwiD-5dwfA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		4 VAL A 307
SER A 308
ASN A 310
ASP A 290
 None
 1.24A 1hwiD-5esoA:
undetectable		 1hwiD-5esoA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ew5 COLICIN-E9

(Escherichia
coli) 		PF03515
(Cloacin) 		4 VAL A 199
SER A 198
ASN A 196
ASP A 188
 None
 1.10A 1hwiD-5ew5A:
undetectable		 1hwiD-5ew5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		4 VAL A 351
ASN A 212
ASP A 397
LYS A  12
 None
 1.34A 1hwiD-5ey9A:
3.5		 1hwiD-5ey9A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 VAL A 207
ASN A 313
ASP A 220
LYS A 223
 None
 1.23A 1hwiD-5f75A:
undetectable		 1hwiD-5f75A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA,
TFA2

(Saccharomyces
cerevisiae) 		PF02186
(TFIIE_beta) 		4 SER S 190
ASN S 222
ASP S 218
LYS S 216
 None
 1.32A 1hwiD-5fmfS:
undetectable		 1hwiD-5fmfS:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii6 ZONA PELLUCIDA
SPERM-BINDING
PROTEIN 2

(Mus musculus) 		no annotation 4 ARG A  57
VAL A  94
ASP A  52
LYS A  53
 None
 1.25A 1hwiD-5ii6A:
undetectable		 1hwiD-5ii6A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Chlamydomonas
reinhardtii) 		PF00400
(WD40) 		4 VAL A 266
SER A 267
ASP A 310
LYS A 352
 None
 0.97A 1hwiD-5mzhA:
undetectable		 1hwiD-5mzhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 VAL A 113
SER A 210
ASN A 323
ASP A 208
 None
 1.29A 1hwiD-5o0sA:
undetectable		 1hwiD-5o0sA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 4 VAL A 207
ASN A 313
ASP A 220
LYS A 223
 None
 1.24A 1hwiD-5oexA:
undetectable		 1hwiD-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 ARG A 558
ASN A 563
ASP A 608
LYS A 566
 None
 1.10A 1hwiD-5ot1A:
undetectable		 1hwiD-5ot1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 ARG A 241
SER A 261
ASP A 263
LYS A 266
 None
ACT  A 302 (-2.8A)
None
None
 1.35A 1hwiD-5t65A:
undetectable		 1hwiD-5t65A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 4 ARG A 202
VAL A 167
SER A 168
ASN A 204
 None
 1.37A 1hwiD-5wabA:
undetectable		 1hwiD-5wabA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3e KINESIN-LIKE PROTEIN

(Caenorhabditis
elegans) 		PF00225
(Kinesin) 		4 VAL A  55
SER A  43
ASN A 413
ASP A 408
 None
 1.27A 1hwiD-5x3eA:
undetectable		 1hwiD-5x3eA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9q PUTATIVE
CYTIDYLYLTRANSFERASE

(Burkholderia
pseudomallei) 		no annotation 4 ARG A 132
VAL A 131
SER A 128
ASP A 123
 None
 1.28A 1hwiD-5x9qA:
undetectable		 1hwiD-5x9qA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 ARG A 548
VAL A 505
ASN A 547
ASP A 549
 None
 1.32A 1hwiD-5ydjA:
undetectable		 1hwiD-5ydjA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 4 VAL A  72
SER A  89
ASN A 103
ASP A 127
 None
None
None
GOL  A 601 (-3.4A)
 1.22A 1hwiD-5zqjA:
undetectable		 1hwiD-5zqjA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
agalactiae) 		no annotation 4 VAL A 109
SER A 154
ASN A 156
ASP A 160
 None
 1.15A 1hwiD-6az6A:
undetectable		 1hwiD-6az6A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 4 ARG A 300
VAL A 290
ASN A 299
ASP A 324
 None
None
None
CA  A 509 (-3.2A)
 1.33A 1hwiD-6br6A:
undetectable		 1hwiD-6br6A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2
SPORULATION-SPECIFIC
PROTEIN 16

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 149
SER A 148
ASP B 572
LYS B 568
 None
 1.26A 1hwiD-6bzgA:
undetectable		 1hwiD-6bzgA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 4 VAL A 277
ASN A 280
ASP A 453
LYS A 456
 None
NAG  A 503 (-1.8A)
None
None
 1.33A 1hwiD-6c4gA:
undetectable		 1hwiD-6c4gA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9s CYTOKINESIS,
APOPTOSIS,
RNA-ASSOCIATED
PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6

(Caenorhabditis
elegans;
Homo sapiens) 		no annotation 4 ARG A 331
SER A 330
ASN A 326
ASP B 189
 None
 1.30A 1hwiD-6f9sA:
undetectable		 1hwiD-6f9sA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbt LYTIC MUREIN
TRANSGLYCOSYLASE

(Pseudomonas
aeruginosa) 		no annotation 4 VAL A 619
SER A 616
ASN A 613
ASP A 373
 None
 1.25A 1hwiD-6fbtA:
undetectable		 1hwiD-6fbtA:
10.71