SIMILAR PATTERNS OF AMINO ACIDS FOR 1HWI_C_115C4_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 GLU A 490
LEU A 411
ALA A 414
LEU A 415
 ACY  A 553 (-3.5A)
None
None
None
 0.87A 1hwiD-1jedA:
undetectable		 1hwiD-1jedA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 HIS A 202
ASN A 231
ALA A 258
LEU A 253
 None
 0.92A 1hwiD-1k1bA:
undetectable		 1hwiD-1k1bA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLU A 112
HIS A 105
LEU A 212
LEU A 216
 None
 0.81A 1hwiD-1kfiA:
4.7		 1hwiD-1kfiA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 HIS D  63
ASN D  91
ALA D 118
LEU D 113
 None
 0.93A 1hwiD-1oy3D:
undetectable		 1hwiD-1oy3D:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 ASN A 260
LEU A 241
ALA A 245
LEU A 246
 None
 0.74A 1hwiD-1oznA:
undetectable		 1hwiD-1oznA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		5 CYH A 365
HIS A 103
LEU A  95
ALA A 250
LEU A 247
 HEM  A 440 (-2.3A)
HEM  A 440 (-3.9A)
HEM  A 440 (-3.7A)
EPB  A 450 ( 3.7A)
None
 1.20A 1hwiD-1q5dA:
undetectable		 1hwiD-1q5dA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		4 GLU A  83
ASN A 271
ALA A 371
LEU A 372
 HMG  A1002 ( 3.4A)
HMG  A1002 (-3.9A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.42A 1hwiD-1qaxA:
27.8		 1hwiD-1qaxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN A 166
LEU A 184
ALA A 204
LEU A 206
 None
 0.79A 1hwiD-1r5mA:
undetectable		 1hwiD-1r5mA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLU A 202
LEU A  49
ALA A  52
LEU A  53
 None
 0.72A 1hwiD-1r8wA:
0.0		 1hwiD-1r8wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 HIS E 119
LEU E 230
ALA E 229
LEU E 233
 None
 0.86A 1hwiD-1skyE:
0.0		 1hwiD-1skyE:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME

(Thermus
thermophilus) 		PF08443
(RimK) 		5 GLU A  13
CYH A  56
LEU A  53
ALA A  52
LEU A   2
 None
 1.35A 1hwiD-1uc8A:
undetectable		 1hwiD-1uc8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udd TRANSCRIPTIONAL
REGULATOR

(Pyrococcus
horikoshii) 		PF03070
(TENA_THI-4) 		4 GLU A 204
LEU A  53
ALA A  56
LEU A  57
 None
 0.73A 1hwiD-1uddA:
undetectable		 1hwiD-1uddA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		4 GLU A  47
LEU A  11
ALA A  14
LEU A  15
 None
 0.90A 1hwiD-1v5xA:
undetectable		 1hwiD-1v5xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 HIS A  66
LEU A  29
ALA A  26
LEU A  25
 None
 0.81A 1hwiD-1vbmA:
undetectable		 1hwiD-1vbmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 GLU A 215
LEU A 237
ALA A 234
LEU A 233
 None
 0.91A 1hwiD-1x0lA:
undetectable		 1hwiD-1x0lA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		5 CYH A  99
ASN A 128
LEU A  87
ALA A  90
LEU A  91
 None
 0.84A 1hwiD-1ydoA:
undetectable		 1hwiD-1ydoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN
ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		4 GLU U 387
LEU E 340
ALA E 258
LEU E 259
 PO4  U   1 (-3.6A)
None
None
None
 0.86A 1hwiD-1z5xU:
undetectable		 1hwiD-1z5xU:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a11 RIBONUCLEASE III

(Mycobacterium
tuberculosis) 		PF14622
(Ribonucleas_3_3) 		4 HIS A  99
LEU A   8
ALA A  11
LEU A  12
 None
 0.68A 1hwiD-2a11A:
undetectable		 1hwiD-2a11A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT

(Homo sapiens) 		PF01012
(ETF) 		4 GLU B  48
LEU B 160
ALA B 179
LEU B 177
 None
 0.91A 1hwiD-2a1uB:
undetectable		 1hwiD-2a1uB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 GLU A  35
LEU A 147
ALA A 150
LEU A 151
 None
 0.91A 1hwiD-2afbA:
undetectable		 1hwiD-2afbA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		4 GLU A 132
LEU A 139
ALA A 142
LEU A 143
 None
 0.78A 1hwiD-2bbzA:
undetectable		 1hwiD-2bbzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5s PROBABLE THIAMINE
BIOSYNTHESIS PROTEIN
THII

(Bacillus
anthracis) 		PF02568
(ThiI)
PF02926
(THUMP) 		4 GLU A 217
HIS A 210
LEU A 241
LEU A 239
 None
 0.69A 1hwiD-2c5sA:
4.2		 1hwiD-2c5sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4p HYPOTHETICAL PROTEIN
TTHA1254

(Thermus
thermophilus) 		PF09390
(DUF1999) 		4 GLU A  69
LEU A 106
ALA A 109
LEU A 110
 None
 0.70A 1hwiD-2d4pA:
undetectable		 1hwiD-2d4pA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 CYH A 356
HIS A 104
LEU A  96
LEU A 238
 HEM  A 430 (-2.4A)
HEM  A 430 (-3.9A)
HEM  A 430 (-4.0A)
None
 0.81A 1hwiD-2dkkA:
undetectable		 1hwiD-2dkkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 GLU A 326
LEU A 396
ALA A 399
LEU A 400
 None
 0.76A 1hwiD-2dsjA:
undetectable		 1hwiD-2dsjA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt6 OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF13953
(PapC_C) 		4 ASN A  66
LEU A  79
ALA A   9
LEU A  77
 None
 0.86A 1hwiD-2kt6A:
undetectable		 1hwiD-2kt6A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mj7 AP-4 COMPLEX SUBUNIT
BETA-1

(Homo sapiens) 		PF09066
(B2-adapt-app_C) 		4 GLU A 137
LEU A  59
ALA A  62
LEU A  63
 None
 0.90A 1hwiD-2mj7A:
2.6		 1hwiD-2mj7A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4e PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		no annotation 4 GLU P 145
LEU P 131
ALA P 134
LEU P 135
 None
 0.94A 1hwiD-2p4eP:
4.5		 1hwiD-2p4eP:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqv MUTT/NUDIX FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00293
(NUDIX) 		4 GLU A  91
LEU A 133
ALA A 136
LEU A 137
 None
 0.78A 1hwiD-2pqvA:
undetectable		 1hwiD-2pqvA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q12 DCC-INTERACTING
PROTEIN 13 ALPHA

(Homo sapiens) 		PF16746
(BAR_3) 		4 GLU A  95
ASN A 217
LEU A 222
LEU A 226
 None
 0.92A 1hwiD-2q12A:
undetectable		 1hwiD-2q12A:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		8 GLU A 559
CYH A 561
LYS A 735
HIS A 752
ASN A 755
LEU A 853
ALA A 856
LEU A 857
 None
 0.21A 1hwiD-2r4fA:
40.7		 1hwiD-2r4fA:
95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2d BOTULINUM NEUROTOXIN
A HEAVY CHAIN

(Clostridium
botulinum) 		PF07952
(Toxin_trans) 		4 GLU B 479
LEU B 815
ALA B 818
LEU B 819
 None
 0.69A 1hwiD-2w2dB:
undetectable		 1hwiD-2w2dB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2o PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF05922
(Inhibitor_I9) 		4 GLU P 145
LEU P 131
ALA P 134
LEU P 135
 None
 0.89A 1hwiD-2w2oP:
4.4		 1hwiD-2w2oP:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 ASN A2175
LEU A2170
ALA A2192
LEU A2168
 None
 0.78A 1hwiD-2ypdA:
undetectable		 1hwiD-2ypdA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		4 HIS A 276
LEU A 386
ALA A 385
LEU A 320
 None
 0.84A 1hwiD-3aczA:
2.1		 1hwiD-3aczA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermotoga
maritima) 		PF02222
(ATP-grasp) 		4 GLU A 197
LEU A 358
ALA A 361
LEU A 362
 None
 0.80A 1hwiD-3ax6A:
2.7		 1hwiD-3ax6A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay3 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Chromohalobacter
salexigens) 		PF01370
(Epimerase) 		4 CYH A  49
HIS A  69
LEU A  93
ALA A  96
 None
 0.88A 1hwiD-3ay3A:
undetectable		 1hwiD-3ay3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		4 LYS A  15
LEU A 413
ALA A 416
LEU A 417
 None
 0.82A 1hwiD-3d6kA:
undetectable		 1hwiD-3d6kA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 GLU A  38
LEU A 173
ALA A 170
LEU A 169
 None
 0.92A 1hwiD-3dqzA:
undetectable		 1hwiD-3dqzA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgy UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Paraburkholderia
xenovorans) 		PF12680
(SnoaL_2) 		4 HIS A  47
LEU A  56
ALA A  60
LEU A  57
 None
None
PEG  A 136 (-3.6A)
PEG  A 136 (-4.5A)
 0.93A 1hwiD-3fgyA:
undetectable		 1hwiD-3fgyA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0x 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 GLU A 556
LEU A 553
ALA A 441
LEU A 442
 None
 0.92A 1hwiD-3h0xA:
undetectable		 1hwiD-3h0xA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 171
LEU A 125
ALA A 122
LEU A 121
 None
 0.84A 1hwiD-3hn7A:
undetectable		 1hwiD-3hn7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		4 CYH A  53
ASN A  65
LEU A  80
ALA A  81
 None
 0.91A 1hwiD-3htxA:
2.4		 1hwiD-3htxA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		4 ASN A 206
LEU A 231
ALA A 255
LEU A 228
 None
 0.83A 1hwiD-3j0aA:
undetectable		 1hwiD-3j0aA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2

(Saccharomyces
cerevisiae) 		PF05916
(Sld5) 		4 ASN B 118
LEU B  73
ALA B  76
LEU B  77
 None
 0.93A 1hwiD-3jc7B:
undetectable		 1hwiD-3jc7B:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6h NITROREDUCTASE
FAMILY PROTEIN

(Agrobacterium
fabrum) 		PF00881
(Nitroreductase) 		4 GLU A  87
LEU A  71
ALA A  74
LEU A  75
 None
 0.67A 1hwiD-3k6hA:
4.5		 1hwiD-3k6hA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		4 ASN A 599
LEU A 521
ALA A 517
LEU A 520
 None
 0.82A 1hwiD-3k8kA:
undetectable		 1hwiD-3k8kA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 ASN E 257
LEU E 265
ALA E 268
LEU E 269
 None
 0.79A 1hwiD-3kfuE:
undetectable		 1hwiD-3kfuE:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)

(Clostridium
acetobutylicum) 		PF07992
(Pyr_redox_2) 		4 ASN A 377
LEU A 379
ALA A 359
LEU A 356
 None
 0.86A 1hwiD-3kljA:
undetectable		 1hwiD-3kljA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 ASN A 372
LEU A 435
ALA A 438
LEU A 439
 None
 0.68A 1hwiD-3kv6A:
undetectable		 1hwiD-3kv6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		4 GLU A 207
LEU A 258
ALA A 257
LEU A 266
 None
 0.94A 1hwiD-3ky9A:
undetectable		 1hwiD-3ky9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		4 CYH B  76
LEU B  11
ALA B  14
LEU B  15
 None
 0.79A 1hwiD-3l4gB:
3.7		 1hwiD-3l4gB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C

(Homo sapiens) 		PF02828
(L27)
PF09058
(L27_1) 		4 ASN A 154
LEU A 148
ALA A 145
LEU A 144
 None
 0.84A 1hwiD-3lraA:
undetectable		 1hwiD-3lraA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 4 HIS A  56
LEU A  15
ALA A  12
LEU A  11
 CL  A 224 (-4.3A)
None
None
None
 0.86A 1hwiD-3m33A:
undetectable		 1hwiD-3m33A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		4 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.70A 1hwiD-3mwtA:
undetectable		 1hwiD-3mwtA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhm RESPONSE REGULATOR

(Myxococcus
xanthus) 		PF00072
(Response_reg) 		4 CYH A  80
LEU A  54
ALA A  57
LEU A  58
 None
 0.86A 1hwiD-3nhmA:
undetectable		 1hwiD-3nhmA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3og9 PROTEIN YAHD A
COPPER INDUCIBLE
HYDROLASE

(Lactococcus
lactis) 		PF01738
(DLH) 		4 ASN A 108
LEU A  19
ALA A 103
LEU A  17
 MLT  A 500 (-3.9A)
None
None
None
 0.94A 1hwiD-3og9A:
undetectable		 1hwiD-3og9A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		4 ASN A  90
LEU A  44
ALA A  47
LEU A  48
 None
 0.85A 1hwiD-3ojaA:
undetectable		 1hwiD-3ojaA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		4 CYH A 355
HIS A  98
LEU A  90
LEU A 236
 HEM  A 501 (-2.4A)
HEM  A 501 ( 3.8A)
HEM  A 501 (-4.2A)
None
 0.87A 1hwiD-3p3lA:
undetectable		 1hwiD-3p3lA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p52 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Campylobacter
jejuni) 		PF02540
(NAD_synthase) 		4 GLU A  84
LEU A  66
ALA A  69
LEU A  70
 None
 0.86A 1hwiD-3p52A:
undetectable		 1hwiD-3p52A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 ASN A 909
LEU A 916
ALA A 919
LEU A 920
 None
 0.57A 1hwiD-3psfA:
undetectable		 1hwiD-3psfA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7b NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF17290
(Arena_ncap_C) 		4 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.89A 1hwiD-3q7bA:
undetectable		 1hwiD-3q7bA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		4 HIS A 185
LEU A 181
ALA A 177
LEU A 180
 None
 0.91A 1hwiD-3q88A:
undetectable		 1hwiD-3q88A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qaw RHO-CLASS
GLUTATHIONE
S-TRANSFERASE

(Laternula
elliptica) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 HIS A 139
LEU A 222
ALA A 180
LEU A 219
 None
 0.91A 1hwiD-3qawA:
undetectable		 1hwiD-3qawA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qay ENDOLYSIN

(Clostridium
virus phiCD27) 		PF01520
(Amidase_3) 		4 CYH A   4
LEU A  37
ALA A  34
LEU A  33
 None
 0.92A 1hwiD-3qayA:
undetectable		 1hwiD-3qayA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)

(Mycobacterium
ulcerans) 		PF01053
(Cys_Met_Meta_PP) 		4 HIS A 279
LEU A 387
ALA A 386
LEU A 324
 None
 0.89A 1hwiD-3qi6A:
undetectable		 1hwiD-3qi6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw4 UMP SYNTHASE

(Leishmania
donovani) 		PF00156
(Pribosyltran)
PF00215
(OMPdecase) 		4 ASN B  51
LEU B  81
ALA B  99
LEU B 103
 U5P  B7485 (-3.3A)
None
None
None
 0.88A 1hwiD-3qw4B:
undetectable		 1hwiD-3qw4B:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqo PCSK9 PRODOMAIN

(Homo sapiens) 		PF05922
(Inhibitor_I9) 		4 GLU P 145
LEU P 131
ALA P 134
LEU P 135
 None
 0.86A 1hwiD-3sqoP:
4.5		 1hwiD-3sqoP:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 GLU A 557
LEU A 640
ALA A 643
LEU A 644
 None
 0.93A 1hwiD-3tbkA:
undetectable		 1hwiD-3tbkA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txv PROBABLE TAGATOSE
6-PHOSPHATE KINASE

(Sinorhizobium
meliloti) 		PF08013
(Tagatose_6_P_K) 		4 GLU A  35
LEU A 296
ALA A 299
LEU A 300
 None
 0.93A 1hwiD-3txvA:
undetectable		 1hwiD-3txvA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u78 LYSINE-SPECIFIC
DEMETHYLASE 7

(Homo sapiens) 		PF02373
(JmjC) 		4 ASN A 372
LEU A 435
ALA A 438
LEU A 439
 None
 0.83A 1hwiD-3u78A:
undetectable		 1hwiD-3u78A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up8 PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE B

(Sinorhizobium
meliloti) 		PF00248
(Aldo_ket_red) 		4 ASN A  49
LEU A  30
ALA A  33
LEU A  34
 None
 0.77A 1hwiD-3up8A:
undetectable		 1hwiD-3up8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		4 HIS A 140
LEU A  20
ALA A  23
LEU A  24
 None
 0.63A 1hwiD-3uykA:
undetectable		 1hwiD-3uykA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viq MATING-TYPE
SWITCHING PROTEIN
SWI5
SWI5-DEPENDENT
RECOMBINATION DNA
REPAIR PROTEIN 1

(Schizosaccharomyces
pombe) 		PF07061
(Swi5)
PF10376
(Mei5) 		4 ASN A 195
LEU B  24
ALA B  27
LEU B  28
 None
 0.78A 1hwiD-3viqA:
undetectable		 1hwiD-3viqA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbm DNA/RNA-BINDING
PROTEIN ALBA 1

(Sulfolobus
shibatae) 		PF01918
(Alba) 		4 GLU A  54
ASN A  58
ALA A  26
LEU A  30
 None
 0.79A 1hwiD-3wbmA:
undetectable		 1hwiD-3wbmA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdb PROBABLE
ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT

(Mycobacterium
tuberculosis) 		PF02861
(Clp_N) 		4 GLU A   3
LEU A  92
ALA A  95
LEU A  96
 None
 0.85A 1hwiD-3wdbA:
undetectable		 1hwiD-3wdbA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 4 GLU A 270
LEU A 419
ALA A 422
LEU A 423
 None
 0.91A 1hwiD-3wvrA:
2.2		 1hwiD-3wvrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 GLU A  12
ASN A 210
ALA A  19
LEU A 202
 None
 0.87A 1hwiD-4a01A:
undetectable		 1hwiD-4a01A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 GLU A  23
LEU A 215
ALA A 212
LEU A 211
 None
 0.79A 1hwiD-4aalA:
undetectable		 1hwiD-4aalA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		4 HIS A 353
ASN A 202
ALA A  51
LEU A  54
 None
 0.71A 1hwiD-4au2A:
undetectable		 1hwiD-4au2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 GLU A 556
LEU A 639
ALA A 642
LEU A 643
 None
 0.89A 1hwiD-4ay2A:
undetectable		 1hwiD-4ay2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9

(Homo sapiens) 		PF11979
(DUF3480) 		4 CYH A1348
LEU A1392
ALA A1395
LEU A1396
 None
 0.76A 1hwiD-4bkwA:
undetectable		 1hwiD-4bkwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 GLU B 107
LEU B 100
ALA B 160
LEU B  98
 None
 0.89A 1hwiD-4ci2B:
undetectable		 1hwiD-4ci2B:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0d POLY [ADP-RIBOSE]
POLYMERASE 16

(Homo sapiens) 		PF00644
(PARP) 		4 CYH A 215
LEU A 187
ALA A 190
LEU A 191
 None
None
3AB  A 301 (-3.9A)
None
 0.74A 1hwiD-4f0dA:
undetectable		 1hwiD-4f0dA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 HIS A 519
LEU A 528
ALA A 531
LEU A 532
 None
 0.94A 1hwiD-4f7zA:
undetectable		 1hwiD-4f7zA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01583
(APS_kinase) 		4 CYH A 176
LEU A 121
ALA A 118
LEU A 117
 None
 0.88A 1hwiD-4fxpA:
undetectable		 1hwiD-4fxpA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 925
LEU A 937
ALA A 940
LEU A 941
 None
 0.84A 1hwiD-4fysA:
undetectable		 1hwiD-4fysA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9z NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF17290
(Arena_ncap_C) 		4 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.93A 1hwiD-4g9zA:
undetectable		 1hwiD-4g9zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		4 ASN A 613
LEU A 595
ALA A 598
LEU A 599
 None
 0.59A 1hwiD-4k17A:
undetectable		 1hwiD-4k17A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		4 GLU A 144
HIS A 155
LEU A 160
LEU A 162
 None
 0.91A 1hwiD-4kfvA:
undetectable		 1hwiD-4kfvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans) 		PF01012
(ETF) 		4 CYH B   6
LEU B  42
ALA B  45
LEU B  46
 FAD  B 301 (-4.8A)
None
None
None
 0.94A 1hwiD-4kpuB:
undetectable		 1hwiD-4kpuB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk5 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 ASN A 225
LEU A 232
ALA A 235
LEU A 236
 None
 0.61A 1hwiD-4lk5A:
undetectable		 1hwiD-4lk5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw8 PUTATIVE EPIMERASE

(Burkholderia
cenocepacia) 		PF01370
(Epimerase) 		4 HIS A  83
LEU A 109
ALA A 112
LEU A 113
 None
 0.67A 1hwiD-4lw8A:
undetectable		 1hwiD-4lw8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 GLU A 699
LEU A 718
ALA A 779
LEU A 780
 None
 0.93A 1hwiD-4nc6A:
undetectable		 1hwiD-4nc6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE

(Toxoplasma
gondii) 		PF00834
(Ribul_P_3_epim) 		4 GLU A  97
LEU A 133
ALA A 136
LEU A 137
 None
 0.64A 1hwiD-4nu7A:
undetectable		 1hwiD-4nu7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8c THERMOSTABLE NPPASE

(Geobacillus
stearothermophilus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ASN A 161
LEU A  97
ALA A 100
LEU A 101
 None
 0.58A 1hwiD-4o8cA:
undetectable		 1hwiD-4o8cA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oud TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 HIS B  66
LEU B  29
ALA B  26
LEU B  25
 HIS  B  66 ( 1.0A)
LEU  B  29 ( 0.6A)
ALA  B  26 ( 0.0A)
LEU  B  25 ( 0.6A)
 0.75A 1hwiD-4oudB:
undetectable		 1hwiD-4oudB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		4 ASN A 261
LEU A 242
ALA A 246
LEU A 247
 None
 0.81A 1hwiD-4p8sA:
undetectable		 1hwiD-4p8sA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw8 TRYPTOPHAN
2,3-DIOXYGENASE

(Homo sapiens) 		PF03301
(Trp_dioxygenase) 		4 HIS A 273
LEU A 289
ALA A 292
LEU A 293
 None
 0.66A 1hwiD-4pw8A:
undetectable		 1hwiD-4pw8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		4 GLU A 342
ASN A 171
LEU A 175
LEU A 179
 None
 0.81A 1hwiD-4r27A:
undetectable		 1hwiD-4r27A:
22.84