SIMILAR PATTERNS OF AMINO ACIDS FOR 1HWI_A_115A2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		9 ARG A 590
MET A 657
SER A 661
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
 RIE  A 876 (-2.9A)
RIE  A 876 (-4.1A)
RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
 0.37A 1hwiA-2r4fA:
53.3		 1hwiA-2r4fA:
95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLU A 112
HIS A 105
LEU A 212
LEU A 216
 None
 0.83A 1hwiB-1kfiA:
4.8		 1hwiB-1kfiA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aeropyrum
pernix) 		PF01791
(DeoC) 		4 CYH A  76
LEU A  99
ALA A 130
LEU A 129
 None
 1.01A 1hwiB-1n7kA:
undetectable		 1hwiB-1n7kA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 ASN A 260
LEU A 241
ALA A 245
LEU A 246
 None
 0.75A 1hwiB-1oznA:
undetectable		 1hwiB-1oznA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		4 GLU A  83
ASN A 271
ALA A 371
LEU A 372
 HMG  A1002 ( 3.4A)
HMG  A1002 (-3.9A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.43A 1hwiB-1qaxA:
17.9		 1hwiB-1qaxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		5 CYH A  99
ASN A 128
LEU A  87
ALA A  90
LEU A  91
 None
 0.85A 1hwiB-1ydoA:
undetectable		 1hwiB-1ydoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN
ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		4 GLU U 387
LEU E 340
ALA E 258
LEU E 259
 PO4  U   1 (-3.6A)
None
None
None
 0.85A 1hwiB-1z5xU:
undetectable		 1hwiB-1z5xU:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a11 RIBONUCLEASE III

(Mycobacterium
tuberculosis) 		PF14622
(Ribonucleas_3_3) 		4 HIS A  99
LEU A   8
ALA A  11
LEU A  12
 None
 0.70A 1hwiB-2a11A:
undetectable		 1hwiB-2a11A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT

(Homo sapiens) 		PF01012
(ETF) 		4 GLU B  48
LEU B 160
ALA B 179
LEU B 177
 None
 0.92A 1hwiB-2a1uB:
undetectable		 1hwiB-2a1uB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		4 GLU A 132
LEU A 139
ALA A 142
LEU A 143
 None
 0.80A 1hwiB-2bbzA:
undetectable		 1hwiB-2bbzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5s PROBABLE THIAMINE
BIOSYNTHESIS PROTEIN
THII

(Bacillus
anthracis) 		PF02568
(ThiI)
PF02926
(THUMP) 		4 GLU A 217
HIS A 210
LEU A 241
LEU A 239
 None
 0.68A 1hwiB-2c5sA:
4.3		 1hwiB-2c5sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4p HYPOTHETICAL PROTEIN
TTHA1254

(Thermus
thermophilus) 		PF09390
(DUF1999) 		4 GLU A  69
LEU A 106
ALA A 109
LEU A 110
 None
 0.64A 1hwiB-2d4pA:
undetectable		 1hwiB-2d4pA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 CYH A 356
HIS A 104
LEU A  96
LEU A 238
 HEM  A 430 (-2.4A)
HEM  A 430 (-3.9A)
HEM  A 430 (-4.0A)
None
 0.82A 1hwiB-2dkkA:
undetectable		 1hwiB-2dkkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASN A 232
LEU A 244
ALA A 247
LEU A 248
 None
 1.06A 1hwiB-2g76A:
undetectable		 1hwiB-2g76A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q12 DCC-INTERACTING
PROTEIN 13 ALPHA

(Homo sapiens) 		PF16746
(BAR_3) 		4 GLU A  95
ASN A 217
LEU A 222
LEU A 226
 None
 0.87A 1hwiB-2q12A:
undetectable		 1hwiB-2q12A:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		8 GLU A 559
CYH A 561
LYS A 735
HIS A 752
ASN A 755
LEU A 853
ALA A 856
LEU A 857
 None
 0.22A 1hwiB-2r4fA:
53.5		 1hwiB-2r4fA:
95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 HIS A 211
LEU A 206
ALA A  93
LEU A  74
 None
 1.01A 1hwiB-2vobA:
undetectable		 1hwiB-2vobA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyr COBALT-ACTIVATED
PEPTIDASE TET1

(Pyrococcus
horikoshii) 		PF05343
(Peptidase_M42) 		4 GLU A 330
ASN A 271
LEU A 323
LEU A 298
 None
 1.00A 1hwiB-2wyrA:
undetectable		 1hwiB-2wyrA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8v CLASS III CHITINASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 GLU A  75
HIS A  17
LEU A  20
LEU A  59
 None
 0.96A 1hwiB-2y8vA:
undetectable		 1hwiB-2y8vA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 ASN A2175
LEU A2170
ALA A2192
LEU A2168
 None
 0.78A 1hwiB-2ypdA:
undetectable		 1hwiB-2ypdA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		4 HIS A 276
LEU A 386
ALA A 385
LEU A 320
 None
 0.84A 1hwiB-3aczA:
undetectable		 1hwiB-3aczA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 GLU B 214
ASN B 314
LEU B 321
ALA B 324
 None
 0.96A 1hwiB-3aeqB:
undetectable		 1hwiB-3aeqB:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay3 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Chromohalobacter
salexigens) 		PF01370
(Epimerase) 		4 CYH A  49
HIS A  69
LEU A  93
ALA A  96
 None
 0.90A 1hwiB-3ay3A:
undetectable		 1hwiB-3ay3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 ASN A 157
LEU A 115
ALA A 111
LEU A 114
 None
 1.01A 1hwiB-3fahA:
undetectable		 1hwiB-3fahA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Schizosaccharomyces
pombe) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF13656
(RNA_pol_L_2) 		4 GLU K  37
LEU C 256
ALA K  90
LEU K  93
 None
 1.04A 1hwiB-3h0gK:
2.7		 1hwiB-3h0gK:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		4 ASN A 206
LEU A 231
ALA A 255
LEU A 228
 None
 0.84A 1hwiB-3j0aA:
undetectable		 1hwiB-3j0aA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6h NITROREDUCTASE
FAMILY PROTEIN

(Agrobacterium
fabrum) 		PF00881
(Nitroreductase) 		4 GLU A  87
LEU A  71
ALA A  74
LEU A  75
 None
 0.67A 1hwiB-3k6hA:
4.8		 1hwiB-3k6hA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 ASN E 257
LEU E 265
ALA E 268
LEU E 269
 None
 0.76A 1hwiB-3kfuE:
undetectable		 1hwiB-3kfuE:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)

(Clostridium
acetobutylicum) 		PF07992
(Pyr_redox_2) 		4 ASN A 377
LEU A 379
ALA A 359
LEU A 356
 None
 0.87A 1hwiB-3kljA:
undetectable		 1hwiB-3kljA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 ASN A 372
LEU A 435
ALA A 438
LEU A 439
 None
 0.66A 1hwiB-3kv6A:
undetectable		 1hwiB-3kv6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		4 GLU A 207
LEU A 258
ALA A 257
LEU A 266
 None
 0.92A 1hwiB-3ky9A:
undetectable		 1hwiB-3ky9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		4 CYH B  76
LEU B  11
ALA B  14
LEU B  15
 None
 0.82A 1hwiB-3l4gB:
3.5		 1hwiB-3l4gB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		4 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.71A 1hwiB-3mwtA:
undetectable		 1hwiB-3mwtA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		4 ASN A 481
LEU A 183
ALA A 186
LEU A 187
 None
 0.97A 1hwiB-3o6xA:
2.4		 1hwiB-3o6xA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osj PHYCOBILISOME LCM
CORE-MEMBRANE LINKER
POLYPEPTIDE

(Synechocystis
sp. PCC 6803) 		PF00427
(PBS_linker_poly) 		4 ASN A 339
LEU A 376
ALA A 379
LEU A 380
 None
 0.98A 1hwiB-3osjA:
undetectable		 1hwiB-3osjA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 ASN A 909
LEU A 916
ALA A 919
LEU A 920
 None
 0.59A 1hwiB-3psfA:
undetectable		 1hwiB-3psfA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7b NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF17290
(Arena_ncap_C) 		4 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.91A 1hwiB-3q7bA:
undetectable		 1hwiB-3q7bA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)

(Mycobacterium
ulcerans) 		PF01053
(Cys_Met_Meta_PP) 		4 HIS A 279
LEU A 387
ALA A 386
LEU A 324
 None
 0.89A 1hwiB-3qi6A:
undetectable		 1hwiB-3qi6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ASN A 272
LEU A  23
ALA A  26
LEU A  27
 None
 0.62A 1hwiB-3qlvA:
undetectable		 1hwiB-3qlvA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLU A 271
LEU A  23
ALA A  26
LEU A  27
 None
 1.01A 1hwiB-3qlvA:
undetectable		 1hwiB-3qlvA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw4 UMP SYNTHASE

(Leishmania
donovani) 		PF00156
(Pribosyltran)
PF00215
(OMPdecase) 		4 ASN B  51
LEU B  81
ALA B  99
LEU B 103
 U5P  B7485 (-3.3A)
None
None
None
 0.89A 1hwiB-3qw4B:
undetectable		 1hwiB-3qw4B:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 HIS A 216
LEU A 199
ALA A 202
LEU A 203
 None
 1.04A 1hwiB-3s2uA:
undetectable		 1hwiB-3s2uA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		4 HIS A 140
LEU A  20
ALA A  23
LEU A  24
 None
 0.65A 1hwiB-3uykA:
undetectable		 1hwiB-3uykA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 4 GLU A 270
LEU A 419
ALA A 422
LEU A 423
 None
 0.90A 1hwiB-3wvrA:
2.3		 1hwiB-3wvrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 GLU A  12
ASN A 210
ALA A  19
LEU A 202
 None
 0.85A 1hwiB-4a01A:
undetectable		 1hwiB-4a01A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		4 HIS A 353
ASN A 202
ALA A  51
LEU A  54
 None
 0.68A 1hwiB-4au2A:
undetectable		 1hwiB-4au2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 GLU A 556
LEU A 639
ALA A 642
LEU A 643
 None
 0.90A 1hwiB-4ay2A:
undetectable		 1hwiB-4ay2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b94 DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 GLU A  63
ASN A 106
LEU A  98
ALA A  94
 None
 1.05A 1hwiB-4b94A:
undetectable		 1hwiB-4b94A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9

(Homo sapiens) 		PF11979
(DUF3480) 		4 CYH A1348
LEU A1392
ALA A1395
LEU A1396
 None
 0.78A 1hwiB-4bkwA:
undetectable		 1hwiB-4bkwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4

(Schizosaccharomyces
pombe) 		PF00533
(BRCT)
PF16589
(BRCT_2) 		4 ASN A 440
LEU A 415
ALA A 418
LEU A 419
 None
 0.98A 1hwiB-4bmdA:
undetectable		 1hwiB-4bmdA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 GLU B 107
LEU B 100
ALA B 160
LEU B  98
 None
 0.87A 1hwiB-4ci2B:
undetectable		 1hwiB-4ci2B:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em2 UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349

(Staphylococcus
aureus) 		PF01047
(MarR) 		4 CYH A 142
HIS A  66
LEU A 137
LEU A 113
 None
 0.92A 1hwiB-4em2A:
undetectable		 1hwiB-4em2A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 HIS A 519
LEU A 528
ALA A 531
LEU A 532
 None
 0.94A 1hwiB-4f7zA:
undetectable		 1hwiB-4f7zA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 GLU B 881
LEU B 847
ALA B 846
LEU B 850
 None
 1.00A 1hwiB-4fhnB:
undetectable		 1hwiB-4fhnB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 925
LEU A 937
ALA A 940
LEU A 941
 None
 0.87A 1hwiB-4fysA:
undetectable		 1hwiB-4fysA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9z NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF17290
(Arena_ncap_C) 		4 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.95A 1hwiB-4g9zA:
undetectable		 1hwiB-4g9zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus) 		PF00144
(Beta-lactamase) 		4 HIS A 124
LEU A 115
ALA A 110
LEU A 109
 None
 0.96A 1hwiB-4gdnA:
undetectable		 1hwiB-4gdnA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7y DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 GLU A  14
ASN A  57
LEU A  49
ALA A  45
 None
 1.05A 1hwiB-4h7yA:
undetectable		 1hwiB-4h7yA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 HIS A 354
LEU A 242
ALA A 245
LEU A 246
 None
 0.99A 1hwiB-4ictA:
2.1		 1hwiB-4ictA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ASN A 243
LEU A 264
ALA A 324
LEU A 325
 None
 1.04A 1hwiB-4iglA:
undetectable		 1hwiB-4iglA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ASN A 172
LEU A 197
ALA A 242
LEU A 239
 LLP  A 196 ( 3.9A)
LLP  A 196 ( 3.7A)
None
None
 0.98A 1hwiB-4j8lA:
2.1		 1hwiB-4j8lA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		4 ASN A 613
LEU A 595
ALA A 598
LEU A 599
 None
 0.57A 1hwiB-4k17A:
undetectable		 1hwiB-4k17A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		4 GLU A 144
HIS A 155
LEU A 160
LEU A 162
 None
 0.94A 1hwiB-4kfvA:
undetectable		 1hwiB-4kfvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN

(Homo sapiens) 		PF15009
(TMEM173) 		4 GLU A 296
LEU A 202
ALA A 262
LEU A 265
 None
 1.01A 1hwiB-4ksyA:
undetectable		 1hwiB-4ksyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk5 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 ASN A 225
LEU A 232
ALA A 235
LEU A 236
 None
 0.57A 1hwiB-4lk5A:
undetectable		 1hwiB-4lk5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE

(Toxoplasma
gondii) 		PF00834
(Ribul_P_3_epim) 		4 GLU A  97
LEU A 133
ALA A 136
LEU A 137
 None
 0.68A 1hwiB-4nu7A:
undetectable		 1hwiB-4nu7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ

(Pseudomonas
putida) 		PF16822
(ALGX) 		4 ASN A 311
LEU A 301
ALA A 202
LEU A 205
 None
 1.00A 1hwiB-4o8vA:
undetectable		 1hwiB-4o8vA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		4 ASN A 261
LEU A 242
ALA A 246
LEU A 247
 None
 0.82A 1hwiB-4p8sA:
undetectable		 1hwiB-4p8sA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw8 TRYPTOPHAN
2,3-DIOXYGENASE

(Homo sapiens) 		PF03301
(Trp_dioxygenase) 		4 HIS A 273
LEU A 289
ALA A 292
LEU A 293
 None
 0.69A 1hwiB-4pw8A:
undetectable		 1hwiB-4pw8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 CYH A  51
LEU A 206
ALA A 209
LEU A 210
 None
 0.97A 1hwiB-4q2cA:
undetectable		 1hwiB-4q2cA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		4 GLU A 342
ASN A 171
LEU A 175
LEU A 179
 None
 0.80A 1hwiB-4r27A:
undetectable		 1hwiB-4r27A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xky DIHYDRODIPICOLINATE
SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00701
(DHDPS) 		4 GLU A 193
LEU A 262
ALA A 265
LEU A 266
 None
 0.63A 1hwiB-4xkyA:
undetectable		 1hwiB-4xkyA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 HIS A 285
LEU A 110
ALA A 113
LEU A 114
 None
 0.91A 1hwiB-4xwtA:
undetectable		 1hwiB-4xwtA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 GLU A 403
LEU A 291
ALA A 294
LEU A 295
 None
 0.84A 1hwiB-4zi6A:
undetectable		 1hwiB-4zi6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		4 ASN B 356
LEU B 272
ALA B 275
LEU B 276
 None
 0.95A 1hwiB-5b3hB:
undetectable		 1hwiB-5b3hB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		4 CYH A 403
LEU A 466
ALA A 469
LEU A 470
 None
 0.98A 1hwiB-5cbmA:
undetectable		 1hwiB-5cbmA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 ASN A 390
LEU A 452
ALA A 455
LEU A 456
 None
 0.71A 1hwiB-5dqfA:
undetectable		 1hwiB-5dqfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 366
LEU A 392
ALA A 349
LEU A 353
 None
 1.05A 1hwiB-5e7jA:
undetectable		 1hwiB-5e7jA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 GLU A 279
LEU A 227
ALA A 194
LEU A 190
 None
 0.87A 1hwiB-5e8hA:
undetectable		 1hwiB-5e8hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		4 GLU C1350
LEU C1050
ALA C1056
LEU C1048
 None
 0.97A 1hwiB-5exrC:
4.8		 1hwiB-5exrC:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		4 GLU B  75
ASN B  78
LEU B  45
LEU B  41
 None
 0.94A 1hwiB-5ey5B:
undetectable		 1hwiB-5ey5B:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 HIS A 270
ASN A 274
LEU A 315
LEU A 311
 None
 0.65A 1hwiB-5fbzA:
undetectable		 1hwiB-5fbzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 ASN A2175
LEU A2170
ALA A2192
LEU A2168
 None
 0.74A 1hwiB-5fzoA:
undetectable		 1hwiB-5fzoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED

(Oryza sativa) 		PF03514
(GRAS) 		4 ASN A 409
LEU A 330
ALA A 333
LEU A 334
 None
 0.95A 1hwiB-5hyzA:
undetectable		 1hwiB-5hyzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 140
LEU A  57
ALA A  77
LEU A  67
 IDV  A 401 ( 4.5A)
IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
 1.05A 1hwiB-5i3oA:
2.5		 1hwiB-5i3oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 GLU A 681
LEU A 695
ALA A 628
LEU A 631
 None
 1.00A 1hwiB-5jjhA:
undetectable		 1hwiB-5jjhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00291
(PALP) 		4 GLU B  82
ASN B  85
LEU B  52
LEU B  48
 None
 0.98A 1hwiB-5kinB:
undetectable		 1hwiB-5kinB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 ASN A 540
LEU A 408
ALA A 411
LEU A 412
 None
 1.04A 1hwiB-5l3dA:
undetectable		 1hwiB-5l3dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		4 GLU M 335
ASN M 331
LEU M 436
ALA M 435
 None
 0.83A 1hwiB-5lc5M:
undetectable		 1hwiB-5lc5M:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ASN A 205
LEU A 186
ALA A 190
LEU A 191
 None
 0.95A 1hwiB-5lfnA:
undetectable		 1hwiB-5lfnA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 GLU A 440
ASN A 417
LEU A 965
ALA A 961
 None
 0.88A 1hwiB-5lq3A:
6.2		 1hwiB-5lq3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		4 GLU A 288
LEU A   8
ALA A 259
LEU A 260
 None
 1.04A 1hwiB-5v2iA:
undetectable		 1hwiB-5v2iA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7

(Homo sapiens) 		PF00098
(zf-CCHC)
PF03828
(PAP_assoc) 		4 HIS A1286
LEU A1288
ALA A1172
LEU A1175
 U  H   4 ( 4.4A)
U  H   4 ( 4.5A)
None
None
 1.06A 1hwiB-5w0mA:
1.4		 1hwiB-5w0mA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE

(Streptococcus
pneumoniae) 		no annotation 4 GLU A  81
ASN A 267
ALA A 368
LEU A 369
 HMG  A 500 (-3.8A)
HMG  A 500 (-3.8A)
HMG  A 500 ( 3.7A)
HMG  A 500 (-4.7A)
 0.40A 1hwiB-5wpkA:
28.7		 1hwiB-5wpkA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 GLU B  87
ASN B  70
ALA B  39
LEU B  40
 None
 0.69A 1hwiB-5xmjB:
undetectable		 1hwiB-5xmjB:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykh PUMILIO HOMOLOG 1

(Homo sapiens) 		no annotation 4 HIS A 133
LEU A  99
ALA A 102
LEU A 103
 None
 1.01A 1hwiB-5ykhA:
undetectable		 1hwiB-5ykhA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 4 CYH A 466
LEU A 479
ALA A 569
LEU A 481
 None
 0.92A 1hwiB-5yy3A:
undetectable		 1hwiB-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 4 ASN A 262
LEU A 260
ALA A 129
LEU A 132
 None
 1.04A 1hwiB-6b07A:
undetectable		 1hwiB-6b07A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 4 HIS A 386
LEU A  92
ALA A 109
LEU A 216
 None
 0.97A 1hwiB-6et9A:
undetectable		 1hwiB-6et9A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 GLU B 175
LEU B 218
ALA B 221
LEU B 222
 None
 0.53A 1hwiB-6evjB:
1.7		 1hwiB-6evjB:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 4 GLU A  68
HIS A 335
ALA A 634
LEU A 638
 None
HEM  A1002 (-3.2A)
HEM  A1002 ( 3.8A)
HEM  A1002 ( 4.2A)
 1.06A 1hwiB-6fwfA:
undetectable		 1hwiB-6fwfA:
11.83