SIMILAR PATTERNS OF AMINO ACIDS FOR 1HTT_A_HISA450

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 GLU A 188
ARG A 220
GLN A 237
GLU A 241
TYR A 287
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
None
 0.96A 1httA-1ggmA:
23.3		 1httA-1ggmA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 GLU A 188
ARG A 220
GLN A 237
TYR A 287
GLY A 307
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
GAP  A1550 ( 4.6A)
 1.18A 1httA-1ggmA:
23.3		 1httA-1ggmA:
25.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 GLU B  81
THR B  83
GLN B 126
GLU B 130
GLY B 285
 None
 0.75A 1httA-1h4vB:
33.9		 1httA-1h4vB:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 GLU B  81
THR B  83
GLN B 126
GLU B 130
TYR B 264
 None
 0.90A 1httA-1h4vB:
33.9		 1httA-1h4vB:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		6 GLU A  83
THR A  85
GLU A 131
TYR A 263
TYR A 264
GLY A 286
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
None
HIS  A 450 ( 4.6A)
None
 1.03A 1httA-1httA:
53.2		 1httA-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		10 GLU A  83
THR A  85
TYR A 107
ARG A 113
GLN A 127
GLU A 131
ARG A 259
TYR A 263
TYR A 264
GLY A 285
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
None
AMP  A 451 ( 2.3A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
AMP  A 451 ( 3.3A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
 0.00A 1httA-1httA:
53.2		 1httA-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		6 GLU A  80
THR A  82
ARG A 112
GLN A 126
GLU A 130
GLY A 286
 None
 0.82A 1httA-1qe0A:
33.8		 1httA-1qe0A:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		6 GLU A  80
THR A  82
ARG A 112
GLU A 130
TYR A 262
GLY A 286
 None
 0.99A 1httA-1qe0A:
33.8		 1httA-1qe0A:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 GLU A  80
THR A  82
TYR A 106
GLN A 126
GLY A 286
 None
 0.87A 1httA-1qe0A:
33.8		 1httA-1qe0A:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 GLU A  80
THR A  82
TYR A 106
TYR A 262
GLY A 286
 None
 0.86A 1httA-1qe0A:
33.8		 1httA-1qe0A:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 THR A  82
GLU A 130
ARG A 257
TYR A 262
GLY A 286
 None
 1.17A 1httA-1qe0A:
33.8		 1httA-1qe0A:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 THR A  82
GLU A 130
ARG A 257
TYR A 262
GLY A 287
 None
 0.89A 1httA-1qe0A:
33.8		 1httA-1qe0A:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 THR A  82
TYR A 106
ARG A 257
TYR A 262
GLY A 286
 None
 1.18A 1httA-1qe0A:
33.8		 1httA-1qe0A:
38.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Thermotoga
maritima) 		PF13393
(tRNA-synt_His) 		6 THR C  55
TYR C  75
GLN C  92
GLU C  96
TYR C 234
GLY C 253
 None
 0.84A 1httA-1usyC:
16.7		 1httA-1usyC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Thermotoga
maritima) 		PF13393
(tRNA-synt_His) 		5 THR C  55
TYR C  75
GLU C  96
TYR C 234
GLY C 254
 None
 1.25A 1httA-1usyC:
16.7		 1httA-1usyC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		5 THR A  86
TYR A 106
ARG A 112
GLN A 126
GLU A 130
 None
 0.92A 1httA-1z7mA:
23.8		 1httA-1z7mA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		5 THR A  86
TYR A 106
ARG A 112
GLU A 130
TYR A 268
 None
 0.98A 1httA-1z7mA:
23.8		 1httA-1z7mA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		5 THR A  86
TYR A 106
ARG A 112
GLU A 130
TYR A 269
 None
 1.15A 1httA-1z7mA:
23.8		 1httA-1z7mA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		5 THR A  86
TYR A 106
GLN A 126
GLU A 130
GLY A 288
 None
 0.80A 1httA-1z7mA:
23.8		 1httA-1z7mA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		5 THR A  86
TYR A 106
GLU A 130
TYR A 269
GLY A 288
 None
 0.75A 1httA-1z7mA:
23.8		 1httA-1z7mA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		5 THR A  86
TYR A 106
GLU A 130
TYR A 269
GLY A 289
 None
 1.10A 1httA-1z7mA:
23.8		 1httA-1z7mA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		5 GLU A 301
THR A 440
ARG A 546
TYR A 442
GLY A 332
 None
 1.32A 1httA-2vsaA:
undetectable		 1httA-2vsaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2n CYTOCHROME C
PEROXIDASE

(Pisum sativum;
Saccharomyces
cerevisiae) 		PF00141
(peroxidase) 		5 GLU A 284
THR A 281
TYR A  23
GLU A 111
GLY A 114
 None
 1.32A 1httA-3e2nA:
undetectable		 1httA-3e2nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hri HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 GLU A 125
THR A 127
GLN A 169
TYR A 317
GLY A 338
 None
 0.98A 1httA-3hriA:
31.2		 1httA-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hri HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 GLU A 125
THR A 127
GLN A 169
TYR A 317
GLY A 358
 None
 1.42A 1httA-3hriA:
31.2		 1httA-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hri HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 THR A 127
GLN A 169
TYR A 317
TYR A 318
GLY A 338
 None
 0.86A 1httA-3hriA:
31.2		 1httA-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3net HISTIDYL-TRNA
SYNTHETASE

(Nostoc sp. PCC
7120) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 THR A 100
ARG A 128
GLN A 142
TYR A 303
GLY A 324
 None
 1.21A 1httA-3netA:
29.5		 1httA-3netA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3od1 ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Bacillus
halodurans) 		PF13393
(tRNA-synt_His) 		8 THR A  83
TYR A 105
ARG A 111
GLN A 125
GLU A 129
TYR A 274
TYR A 275
GLY A 294
 None
None
PEG  A 399 (-4.6A)
PEG  A 398 ( 4.2A)
None
None
None
None
 1.06A 1httA-3od1A:
27.7		 1httA-3od1A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3od1 ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Bacillus
halodurans) 		PF13393
(tRNA-synt_His) 		6 THR A  83
TYR A 105
GLU A 129
TYR A 274
TYR A 275
GLY A 295
 None
 1.26A 1httA-3od1A:
27.7		 1httA-3od1A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3od1 ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Bacillus
halodurans) 		PF13393
(tRNA-synt_His) 		5 TYR A 105
ARG A 111
GLN A 125
GLU A 129
TYR A 274
 None
PEG  A 399 (-4.6A)
PEG  A 398 ( 4.2A)
None
None
 1.17A 1httA-3od1A:
27.7		 1httA-3od1A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rac HISTIDINE-TRNA
LIGASE

(Alicyclobacillus
acidocaldarius) 		PF13393
(tRNA-synt_His) 		5 GLU A  95
GLN A 145
TYR A 310
TYR A 333
GLY A 348
 LMR  A 401 (-3.4A)
LMR  A 401 (-3.7A)
None
LMR  A 401 (-4.1A)
LMR  A 401 (-3.4A)
 1.16A 1httA-3racA:
26.2		 1httA-3racA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rac HISTIDINE-TRNA
LIGASE

(Alicyclobacillus
acidocaldarius) 		PF13393
(tRNA-synt_His) 		6 GLU A  95
THR A  97
GLU A 149
TYR A 310
TYR A 311
GLY A 331
 LMR  A 401 (-3.4A)
LMR  A 401 (-3.5A)
LMR  A 401 (-3.7A)
None
LMR  A 401 (-4.5A)
None
 0.99A 1httA-3racA:
26.2		 1httA-3racA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rac HISTIDINE-TRNA
LIGASE

(Alicyclobacillus
acidocaldarius) 		PF13393
(tRNA-synt_His) 		7 GLU A  95
THR A  97
TYR A 119
ARG A 125
GLN A 145
GLU A 149
GLY A 330
 LMR  A 401 (-3.4A)
LMR  A 401 (-3.5A)
None
None
LMR  A 401 (-3.7A)
LMR  A 401 (-3.7A)
LMR  A 401 (-3.5A)
 1.00A 1httA-3racA:
26.2		 1httA-3racA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rac HISTIDINE-TRNA
LIGASE

(Alicyclobacillus
acidocaldarius) 		PF13393
(tRNA-synt_His) 		9 GLU A  95
THR A  97
TYR A 119
GLN A 145
GLU A 149
ARG A 306
TYR A 310
TYR A 311
GLY A 330
 LMR  A 401 (-3.4A)
LMR  A 401 (-3.5A)
None
LMR  A 401 (-3.7A)
LMR  A 401 (-3.7A)
None
None
LMR  A 401 (-4.5A)
LMR  A 401 (-3.5A)
 0.62A 1httA-3racA:
26.2		 1httA-3racA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rac HISTIDINE-TRNA
LIGASE

(Alicyclobacillus
acidocaldarius) 		PF13393
(tRNA-synt_His) 		5 TYR A 119
ARG A 125
GLN A 145
GLU A 149
TYR A 310
 None
None
LMR  A 401 (-3.7A)
LMR  A 401 (-3.7A)
None
 1.34A 1httA-3racA:
26.2		 1httA-3racA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		10 GLU A  90
THR A  92
TYR A 114
ARG A 120
GLN A 134
GLU A 138
ARG A 265
TYR A 269
TYR A 270
GLY A 291
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
None
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-3.8A)
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
 0.53A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		7 GLU A  90
THR A  92
TYR A 114
GLU A 138
TYR A 269
TYR A 270
GLY A 292
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
None
HIS  A 501 (-2.7A)
None
HIS  A 501 (-4.5A)
None
 1.00A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 GLU A 138
THR A  92
TYR A 269
GLU A  90
TYR A 114
 HIS  A 501 (-2.7A)
HIS  A 501 (-3.5A)
None
HIS  A 501 (-3.6A)
None
 1.43A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 TYR A 114
ARG A 120
GLN A 134
GLU A 138
TYR A 270
 None
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-4.5A)
 1.10A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		7 THR A 132
ARG A 157
GLN A 173
ARG A 326
TYR A 330
TYR A 331
GLY A 360
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
HIS  A1001 (-3.6A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
 0.56A 1httA-4phcA:
33.5		 1httA-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlj BETA-GLUCOSIDASE 7

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 GLU A 440
TYR A 131
GLN A  29
TYR A 315
GLY A 386
 CTT  A1001 (-2.7A)
None
CTT  A1001 (-3.0A)
CTT  A1001 (-4.2A)
None
 1.50A 1httA-4qljA:
undetectable		 1httA-4qljA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrp HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
cruzi) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		6 GLU A 126
THR A 128
GLN A 170
TYR A 318
TYR A 319
GLY A 339
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
 0.59A 1httA-4yrpA:
33.6		 1httA-4yrpA:
27.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e3i HISTIDINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		6 GLU A  85
THR A  87
GLU A 133
TYR A 265
TYR A 266
GLY A 288
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
HIS  A 502 (-2.6A)
None
HIS  A 502 (-4.7A)
None
 1.01A 1httA-5e3iA:
43.6		 1httA-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e3i HISTIDINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		9 GLU A  85
THR A  87
TYR A 109
ARG A 115
GLN A 129
GLU A 133
TYR A 265
TYR A 266
GLY A 287
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
None
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
HIS  A 502 (-2.6A)
None
HIS  A 502 (-4.7A)
HIS  A 502 ( 3.8A)
 0.27A 1httA-5e3iA:
43.6		 1httA-5e3iA:
55.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Psychrobacter
arcticus) 		PF13393
(tRNA-synt_His) 		5 THR A  78
TYR A  98
GLN A 118
GLU A 122
GLY A 285
 SR  A 401 (-3.4A)
None
MPD  A 407 (-4.2A)
None
MPD  A 406 ( 3.9A)
 1.14A 1httA-5m8hA:
24.9		 1httA-5m8hA:
26.89