SIMILAR PATTERNS OF AMINO ACIDS FOR 1HSH_C_MK1C402_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a05 3-ISOPROPYLMALATE
DEHYDROGENASE


(Acidithiobacillus
ferrooxidans)
PF00180
(Iso_dh)
4 ALA A 290
GLY A 260
ILE A 259
ILE A  16
None
0.69A 1hshD-1a05A:
0.0
1hshD-1a05A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aec ACTINIDIN

(Actinidia
chinensis)
PF00112
(Peptidase_C1)
5 ALA A  30
GLY A  36
ILE A  37
ILE A  83
ILE A  31
None
1.43A 1hshD-1aecA:
0.6
1hshD-1aecA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN


(Sphingomonas
paucimobilis)
PF02900
(LigB)
4 ALA B 175
GLY B 169
ILE B 148
ILE B 106
None
0.69A 1hshD-1bouB:
0.0
1hshD-1bouB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddz CARBONIC ANHYDRASE

(Porphyridium
purpureum)
PF00484
(Pro_CA)
5 ALA A 410
GLY A 402
ILE A 401
ILE A 114
ILE A 414
None
1.46A 1hshD-1ddzA:
0.0
1hshD-1ddzA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK


(Escherichia
coli)
PF00012
(HSP70)
5 ALA D 153
GLY D 158
ILE D 160
ILE D  69
ILE D  73
None
0.76A 1hshD-1dkgD:
undetectable
1hshD-1dkgD:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE


(Sus scrofa)
PF00151
(Lipase)
PF01477
(PLAT)
5 ALA A 272
GLY A 309
ILE A 203
ILE A  74
ILE A  90
None
1.11A 1hshD-1ethA:
0.0
1hshD-1ethA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa)
PF13354
(Beta-lactamase2)
5 ALA A 248
GLY A 283
ILE A 286
PRO A 226
ILE A 231
None
1.17A 1hshD-1g68A:
undetectable
1hshD-1g68A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv3 MANGANESE SUPEROXIDE
DISMUTASE


(Nostoc sp. PCC
7120)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
4 GLY A  27
ILE A  26
ILE A 230
ILE A 123
None
0.71A 1hshD-1gv3A:
undetectable
1hshD-1gv3A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 ALA A  28
GLY A  48
PRO A  81
ILE A  84
A79  A 800 (-3.2A)
A79  A 800 (-4.1A)
A79  A 800 ( 3.4A)
A79  A 800 (-3.8A)
0.72A 1hshD-1hvcA:
12.6
1hshD-1hvcA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ARG A   8
ASP A  25
GLY A  49
ILE A  50
PRO A  81
A79  A 800 (-3.6A)
A79  A 800 (-2.8A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
A79  A 800 ( 3.4A)
0.90A 1hshD-1hvcA:
12.6
1hshD-1hvcA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 ASP A  25
ALA A  28
GLY A  49
ILE A  50
PRO A  81
ILE A  84
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
A79  A 800 ( 3.9A)
A79  A 800 (-3.6A)
0.65A 1hshD-1hvcA:
12.6
1hshD-1hvcA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 ASP A  25
ALA A  28
GLY A  49
ILE A  50
PRO A  81
ILE A  84
A79  A 800 (-2.8A)
A79  A 800 (-3.2A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
A79  A 800 ( 3.4A)
A79  A 800 (-3.8A)
0.58A 1hshD-1hvcA:
12.6
1hshD-1hvcA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN


(Acidianus
ambivalens)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 ALA F 115
GLY F 149
ILE F 152
ILE F 183
ILE F 185
None
0.95A 1hshD-1j8mF:
undetectable
1hshD-1j8mF:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum)
PF05034
(MAAL_N)
PF07476
(MAAL_C)
5 ARG A 298
ALA A 287
GLY A 244
ILE A 243
ILE A 251
None
1.09A 1hshD-1kczA:
undetectable
1hshD-1kczA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN


(Salmonella
enterica)
PF00654
(Voltage_CLC)
5 ARG A 340
ALA A 370
GLY A 393
PRO A 321
ILE A 320
None
1.15A 1hshD-1kplA:
undetectable
1hshD-1kplA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE


(Schizosaccharomyces
pombe)
PF00885
(DMRL_synthase)
5 ALA A 150
GLY A  83
ILE A  84
ILE A  54
ILE A  20
None
0.81A 1hshD-1kz1A:
undetectable
1hshD-1kz1A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE


(Pseudomonas sp.
CBS3)
no annotation 4 ASP A  76
ALA A  72
GLY A  20
ILE A  11
None
0.69A 1hshD-1lo9A:
undetectable
1hshD-1lo9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24


(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 ALA B 177
ILE B 628
PRO B 209
ILE B 207
ILE B 182
None
1.38A 1hshD-1m2vB:
undetectable
1hshD-1m2vB:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli)
PF13385
(Laminin_G_3)
PF13859
(BNR_3)
5 ALA A 221
ILE A 197
PRO A 232
ILE A 243
ILE A 208
None
1.42A 1hshD-1mz5A:
undetectable
1hshD-1mz5A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE


(Arabidopsis
thaliana)
PF16363
(GDP_Man_Dehyd)
5 ALA A  90
GLY A  57
ILE A  33
PRO A 107
ILE A 102
None
1.28A 1hshD-1n7gA:
undetectable
1hshD-1n7gA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 CONSERVED
HYPOTHETICAL PROTEIN


(Archaeoglobus
fulgidus)
PF01798
(Nop)
4 ARG B 135
ALA B 163
GLY B 158
ILE B 142
None
0.71A 1hshD-1nt2B:
undetectable
1hshD-1nt2B:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN


(Salmonella
enterica)
PF02264
(LamB)
5 ARG Q 338
ALA Q 356
GLY Q 109
ILE Q 108
ILE Q 195
None
0.94A 1hshD-1oh2Q:
undetectable
1hshD-1oh2Q:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24


(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 ALA A 177
ILE A 628
PRO A 209
ILE A 207
ILE A 182
None
1.36A 1hshD-1pd1A:
undetectable
1hshD-1pd1A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppr PERIDININ-CHLOROPHYL
L PROTEIN


(Amphidinium
carterae)
PF02429
(PCP)
4 GLY M  71
ILE M  73
ILE M 207
ILE M 211
None
PID  M 614 (-4.4A)
PID  M 612 (-4.1A)
CLA  M 601 (-4.1A)
0.72A 1hshD-1pprM:
undetectable
1hshD-1pprM:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE


(Geobacillus
stearothermophilus)
PF06964
(Alpha-L-AF_C)
4 ALA A 121
ILE A  57
ILE A  28
ILE A  68
None
0.68A 1hshD-1pz3A:
undetectable
1hshD-1pz3A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION


(Saccharomyces
cerevisiae)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ALA A 201
GLY A 223
ILE A 321
ILE A 319
None
0.64A 1hshD-1q1nA:
undetectable
1hshD-1q1nA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 ALA A 468
GLY A 635
ILE A 652
ILE A 536
ILE A 462
None
0.95A 1hshD-1q3xA:
undetectable
1hshD-1q3xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
4 ARG A 287
ASP A 282
ALA A 697
GLY A 726
None
0.71A 1hshD-1q8yA:
undetectable
1hshD-1q8yA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rif DNA HELICASE UVSW

(Escherichia
virus T4)
PF04851
(ResIII)
5 ALA A 237
GLY A 257
ILE A 132
ILE A 246
ILE A 242
None
None
AU  A 287 ( 4.7A)
None
None
1.48A 1hshD-1rifA:
undetectable
1hshD-1rifA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV


(Mus musculus)
PF00194
(Carb_anhydrase)
5 ARG A 254
GLY A 145
PRO A  30
ILE A  31
ILE A  33
None
1.19A 1hshD-1rj6A:
undetectable
1hshD-1rj6A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE


(Pseudomonas
aeruginosa)
PF16363
(GDP_Man_Dehyd)
4 ARG A  45
ALA A  19
GLY A   9
ILE A  53
None
None
NDP  A1501 (-3.3A)
None
0.72A 1hshD-1rpnA:
undetectable
1hshD-1rpnA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE


(Escherichia
coli)
PF00465
(Fe-ADH)
5 ARG A 120
ALA A 106
GLY A  80
ILE A  74
ILE A 154
None
1.25A 1hshD-1rrmA:
undetectable
1hshD-1rrmA:
15.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
8 ARG A   8
ASP A  25
ALA A  28
GLY A  49
ILE A  50
PRO A  81
ILE A  82
ILE A  84
None
0.62A 1hshD-1sivA:
20.8
1hshD-1sivA:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
5 ARG A   8
GLY A  51
ILE A  50
PRO A  81
ILE A  82
None
1.45A 1hshD-1sivA:
20.8
1hshD-1sivA:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
4 ASP A  25
ALA A  28
GLY A  48
ILE A  84
None
0.66A 1hshD-1sivA:
20.8
1hshD-1sivA:
86.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1squ CHEX PROTEIN

(Thermotoga
maritima)
PF13690
(CheX)
5 ALA A 101
GLY A  50
ILE A  52
ILE A  46
ILE A 113
None
1.39A 1hshD-1squA:
undetectable
1hshD-1squA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1swf CIRCULARLY PERMUTED
CORE-STREPTAVIDIN
E51/A46


(Streptomyces
avidinii)
PF01382
(Avidin)
5 ALA A  33
GLY A  41
ILE A  30
ILE A 104
ILE A  17
None
1.38A 1hshD-1swfA:
undetectable
1hshD-1swfA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE


(Synechococcus
elongatus)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
5 ALA A 336
GLY A 330
PRO A 408
ILE A 354
ILE A 333
None
1.31A 1hshD-1tezA:
undetectable
1hshD-1tezA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis)
PF02595
(Gly_kinase)
5 ALA A 334
GLY A 317
ILE A 337
PRO A   7
ILE A 283
None
1.29A 1hshD-1to6A:
undetectable
1hshD-1to6A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A


(Staphylococcus
aureus)
PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14)
5 ARG A  17
ALA A  59
GLY A  66
ILE A  13
ILE A  70
None
1.05A 1hshD-1tv8A:
undetectable
1hshD-1tv8A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1typ TRYPANOTHIONE
REDUCTASE


(Crithidia
fasciculata)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 442
GLY A 426
ILE A 415
ILE A 437
ILE A 438
None
1.48A 1hshD-1typA:
undetectable
1hshD-1typA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfg GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]


(Escherichia
coli)
PF13522
(GATase_6)
4 ARG A  22
ALA A   6
GLY A 183
ILE A  15
None
0.55A 1hshD-1xfgA:
undetectable
1hshD-1xfgA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133


(Homo sapiens)
no annotation 5 ALA A 178
ILE A 221
PRO A 234
ILE A 240
ILE A 184
None
1.47A 1hshD-1xksA:
undetectable
1hshD-1xksA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt5 VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3


(Branchiostoma
floridae)
PF07686
(V-set)
5 ALA A 124
GLY A 121
ILE A 116
PRO A  37
ILE A  39
None
1.44A 1hshD-1xt5A:
undetectable
1hshD-1xt5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE


(Staphylococcus
aureus)
PF04131
(NanE)
5 ALA A  28
GLY A  38
ILE A   7
ILE A  47
ILE A  50
None
0.99A 1hshD-1y0eA:
undetectable
1hshD-1y0eA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1


(Borreliella
burgdorferi)
PF02127
(Peptidase_M18)
4 ILE A 221
PRO A 107
ILE A 117
ILE A 194
None
0.70A 1hshD-1y7eA:
undetectable
1hshD-1y7eA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)


(Dunaliella
salina)
PF00194
(Carb_anhydrase)
5 ALA A 210
GLY A 155
PRO A  38
ILE A  39
ILE A  41
None
1.37A 1hshD-1y7wA:
undetectable
1hshD-1y7wA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)


(Dunaliella
salina)
PF00194
(Carb_anhydrase)
5 ARG A 269
ALA A 210
GLY A 155
ILE A  39
ILE A  41
None
0.92A 1hshD-1y7wA:
undetectable
1hshD-1y7wA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT


(Methanocaldococcus
jannaschii)
PF01420
(Methylase_S)
4 ALA A  94
GLY A 117
ILE A 118
ILE A  59
None
0.67A 1hshD-1yf2A:
undetectable
1hshD-1yf2A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE


(Saccharomyces
cerevisiae)
PF00343
(Phosphorylase)
5 ALA A 695
GLY A 485
ILE A 486
ILE A 703
ILE A 699
None
1.28A 1hshD-1ygpA:
undetectable
1hshD-1ygpA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE


(Streptococcus
pyogenes)
PF04131
(NanE)
5 ALA A  42
GLY A  52
ILE A  19
ILE A  61
ILE A  64
None
0.95A 1hshD-1yxyA:
undetectable
1hshD-1yxyA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE


(Burkholderia
cepacia)
PF00202
(Aminotran_3)
5 ALA A 428
GLY A 379
ILE A 395
ILE A 351
ILE A 429
None
1.35A 1hshD-1z3zA:
undetectable
1hshD-1z3zA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND


(Bacillus
subtilis)
PF00881
(Nitroreductase)
5 ALA A  73
GLY A 131
ILE A  14
PRO A 134
ILE A 135
None
None
None
FMN  A 301 (-4.0A)
FMN  A 301 (-3.8A)
1.25A 1hshD-1zchA:
undetectable
1hshD-1zchA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 ALA A 468
GLY A 635
ILE A 652
ILE A 536
ILE A 462
None
0.95A 1hshD-1zjkA:
undetectable
1hshD-1zjkA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a00 POTASSIUM-TRANSPORTI
NG ATPASE B CHAIN


(Escherichia
coli)
no annotation 4 GLY A 385
ILE A 393
ILE A 443
ILE A 352
None
0.66A 1hshD-2a00A:
undetectable
1hshD-2a00A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE


(Plasmodium
yoelii)
PF00215
(OMPdecase)
4 ALA A 248
GLY A 268
ILE A 269
ILE A 264
None
SO4  A2002 ( 4.9A)
None
None
0.69A 1hshD-2aqwA:
undetectable
1hshD-2aqwA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2av5 RIBONUCLEASE P
PROTEIN COMPONENT 2


(Pyrococcus
furiosus)
PF01900
(RNase_P_Rpp14)
5 ARG A  71
ALA A  20
ILE A  38
ILE A  59
ILE A  69
None
1.28A 1hshD-2av5A:
undetectable
1hshD-2av5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1


(Homo sapiens)
PF00330
(Aconitase)
PF00694
(Aconitase_C)
5 ALA A  46
ILE A 235
PRO A 240
ILE A  39
ILE A  63
None
1.26A 1hshD-2b3xA:
undetectable
1hshD-2b3xA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4w HYPOTHETICAL
PROTEIN, CONSERVED


(Leishmania
major)
PF08950
(DUF1861)
5 ALA A 266
GLY A 245
ILE A 243
PRO A 296
ILE A 206
None
1.21A 1hshD-2b4wA:
undetectable
1hshD-2b4wA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
5 ASP A 275
GLY A 233
ILE A 232
PRO A 250
ILE A 252
None
1.24A 1hshD-2b5mA:
undetectable
1hshD-2b5mA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp5 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50


(Rattus
norvegicus)
PF00928
(Adap_comp_sub)
5 ALA M 194
GLY M 429
PRO M 396
ILE M 284
ILE M 283
None
1.21A 1hshD-2bp5M:
undetectable
1hshD-2bp5M:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE


(Pestivirus A)
PF00998
(RdRP_3)
4 GLY A 362
ILE A 361
ILE A 298
ILE A 380
None
0.72A 1hshD-2cjqA:
undetectable
1hshD-2cjqA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE


(Bacillus cereus)
PF03372
(Exo_endo_phos)
5 GLY A 193
ILE A 192
PRO A 223
ILE A 267
ILE A 303
None
1.35A 1hshD-2ddtA:
undetectable
1hshD-2ddtA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF00180
(Iso_dh)
5 ARG A 215
GLY A 305
ILE A 308
ILE A 146
ILE A 147
None
1.37A 1hshD-2dhtA:
undetectable
1hshD-2dhtA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium)
PF00232
(Glyco_hydro_1)
5 ALA A 208
GLY A 225
ILE A 166
PRO A 171
ILE A 201
None
1.49A 1hshD-2e3zA:
undetectable
1hshD-2e3zA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew7 PEPTIDE DEFORMYLASE

(Helicobacter
pylori)
PF01327
(Pep_deformylase)
5 ALA A 128
ILE A  84
PRO A  81
ILE A 140
ILE A 136
None
1.27A 1hshD-2ew7A:
undetectable
1hshD-2ew7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B


(Staphylococcus
aureus)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
5 GLY B 103
ILE B 118
PRO B  98
ILE B  99
ILE B  70
None
1.03A 1hshD-2f2aB:
undetectable
1hshD-2f2aB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1


(Mus musculus)
PF06367
(Drf_FH3)
PF06371
(Drf_GBD)
4 ALA A 238
GLY A 231
ILE A 232
ILE A 209
None
0.67A 1hshD-2f31A:
undetectable
1hshD-2f31A:
17.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE


(Equine
infectious
anemia virus)
PF00077
(RVP)
6 ARG A   8
ASP A  25
ALA A  28
GLY A  55
PRO A  86
ILE A  89
LP1  A 201 (-3.5A)
LP1  A 201 (-2.3A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.4A)
LP1  A 201 (-3.9A)
LP1  A 201 (-4.2A)
0.55A 1hshD-2fmbA:
15.9
1hshD-2fmbA:
37.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE


(Equine
infectious
anemia virus)
PF00077
(RVP)
4 ASP A  25
ALA A  28
GLY A  54
ILE A  89
LP1  A 201 (-2.3A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
LP1  A 201 (-4.2A)
0.71A 1hshD-2fmbA:
15.9
1hshD-2fmbA:
37.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq1 ISOCHORISMATASE

(Escherichia
coli)
PF00550
(PP-binding)
PF00857
(Isochorismatase)
5 GLY A 242
ILE A 239
PRO A 232
ILE A 273
ILE A 222
MG  A 997 (-4.4A)
None
None
None
None
1.42A 1hshD-2fq1A:
undetectable
1hshD-2fq1A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvz INOSITOL
MONOPHOSPHATASE 2


(Homo sapiens)
PF00459
(Inositol_P)
5 GLY A  31
ILE A  33
PRO A 102
ILE A 100
ILE A 120
None
1.32A 1hshD-2fvzA:
undetectable
1hshD-2fvzA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25


(Archaeoglobus
fulgidus)
PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C)
4 ARG A 327
ALA A 309
GLY A 294
ILE A 295
None
0.70A 1hshD-2fwrA:
undetectable
1hshD-2fwrA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2d ATP:COBALAMIN
ADENOSYLTRANSFERASE


(Mycobacterium
tuberculosis)
PF01923
(Cob_adeno_trans)
5 ARG A 164
ALA A  73
ILE A  66
ILE A  97
ILE A  92
None
1.48A 1hshD-2g2dA:
undetectable
1hshD-2g2dA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE


(Thermotoga
maritima)
PF00579
(tRNA-synt_1b)
4 ALA A 134
ILE A 128
ILE A  97
ILE A 161
None
0.65A 1hshD-2g36A:
undetectable
1hshD-2g36A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK


(Escherichia
coli)
PF01041
(DegT_DnrJ_EryC1)
5 ASP A 106
ALA A  85
GLY A 336
ILE A 109
ILE A 107
None
1.18A 1hshD-2gmuA:
undetectable
1hshD-2gmuA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzl 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Escherichia
coli)
PF02542
(YgbB)
5 ALA A  40
ILE A  99
PRO A 103
ILE A  18
ILE A  20
None
1.42A 1hshD-2gzlA:
undetectable
1hshD-2gzlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE


(Trypanosoma
brucei)
PF00365
(PFK)
4 GLY A 123
ILE A 124
ILE A 116
ILE A 102
None
0.63A 1hshD-2higA:
undetectable
1hshD-2higA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE


(Methanocaldococcus
jannaschii)
PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7)
5 ALA A 276
GLY A 218
ILE A 217
ILE A 228
ILE A 283
None
1.24A 1hshD-2hmfA:
undetectable
1hshD-2hmfA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE


(Thermotoga
maritima)
PF00480
(ROK)
5 ALA A 214
GLY A 189
ILE A 349
ILE A 308
ILE A 206
None
1.28A 1hshD-2hoeA:
undetectable
1hshD-2hoeA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr7 INSULIN RECEPTOR

(Homo sapiens)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
4 ALA A  92
ILE A 119
ILE A 136
ILE A 112
None
0.66A 1hshD-2hr7A:
undetectable
1hshD-2hr7A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE


(Escherichia
coli)
PF01380
(SIS)
PF13522
(GATase_6)
4 ARG A  22
ALA A   6
GLY A 183
ILE A  15
None
0.55A 1hshD-2j6hA:
undetectable
1hshD-2j6hA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kho HEAT SHOCK PROTEIN
70


(Escherichia
coli)
PF00012
(HSP70)
5 ALA A 153
GLY A 158
ILE A 160
ILE A  69
ILE A  73
None
0.79A 1hshD-2khoA:
undetectable
1hshD-2khoA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt9 FLAVODOXIN-2

(Escherichia
coli)
PF00258
(Flavodoxin_1)
5 ALA A  17
GLY A  86
ILE A  53
ILE A  50
ILE A  21
None
1.15A 1hshD-2mt9A:
undetectable
1hshD-2mt9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE


(Pseudomonas sp.
101)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 ALA A 140
GLY A 121
ILE A 122
PRO A  37
ILE A 351
None
AZI  A 395 (-3.6A)
NAD  A 394 ( 3.5A)
None
None
1.16A 1hshD-2nadA:
undetectable
1hshD-2nadA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE


(Nostoc
punctiforme)
PF00221
(Lyase_aromatic)
4 ALA A 220
ILE A 177
ILE A 144
ILE A 139
None
0.63A 1hshD-2nyfA:
undetectable
1hshD-2nyfA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o14 HYPOTHETICAL PROTEIN
YXIM


(Bacillus
subtilis)
PF13472
(Lipase_GDSL_2)
4 ALA A 270
ILE A 262
ILE A 224
ILE A 228
None
0.67A 1hshD-2o14A:
undetectable
1hshD-2o14A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW


(Escherichia
virus T4)
PF00271
(Helicase_C)
PF04851
(ResIII)
5 ALA A 237
GLY A 257
ILE A 132
ILE A 246
ILE A 242
None
1.48A 1hshD-2ocaA:
undetectable
1hshD-2ocaA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW


(Escherichia
virus T4)
PF00271
(Helicase_C)
PF04851
(ResIII)
5 ALA A 267
ILE A  51
PRO A  61
ILE A 246
ILE A 242
None
1.45A 1hshD-2ocaA:
undetectable
1hshD-2ocaA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE


(Neisseria
meningitidis)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
5 ALA A 738
GLY A 698
ILE A 677
ILE A 771
ILE A 739
None
1.16A 1hshD-2olsA:
undetectable
1hshD-2olsA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pft EXOCYTOSIS PROTEIN

(Mus musculus)
PF03081
(Exo70)
5 ALA A 492
ILE A 530
PRO A 594
ILE A 593
ILE A 493
None
1.29A 1hshD-2pftA:
undetectable
1hshD-2pftA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE


(Sinorhizobium
meliloti)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A  49
ILE A 305
PRO A 272
ILE A 313
ILE A 278
None
1.09A 1hshD-2pgwA:
undetectable
1hshD-2pgwA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ALA A 128
GLY A 306
ILE A 303
PRO A 120
ILE A 116
None
1.50A 1hshD-2pwzA:
undetectable
1hshD-2pwzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3f RAS-RELATED
GTP-BINDING PROTEIN
D


(Homo sapiens)
PF04670
(Gtr1_RagA)
5 ALA A 121
GLY A 118
ILE A 115
ILE A  96
ILE A  46
None
1.22A 1hshD-2q3fA:
undetectable
1hshD-2q3fA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3


(Homo sapiens)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
5 ALA A  18
GLY A  12
PRO A  74
ILE A   8
ILE A   7
None
None
SO4  A 701 (-4.8A)
None
None
1.15A 1hshD-2qk4A:
undetectable
1hshD-2qk4A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens)
no annotation 5 ARG A 454
ALA A 447
GLY A 392
ILE A 381
ILE A 450
None
None
CA  A 619 (-4.2A)
None
None
1.24A 1hshD-2quaA:
undetectable
1hshD-2quaA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens)
no annotation 5 ARG A 454
ALA A 447
GLY A 392
ILE A 416
ILE A 450
None
None
CA  A 619 (-4.2A)
None
None
1.32A 1hshD-2quaA:
undetectable
1hshD-2quaA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf7 CYTOCHROME C-552

(Escherichia
coli)
PF02335
(Cytochrom_C552)
5 ALA A  80
GLY A 445
PRO A 432
ILE A 434
ILE A  77
None
1.35A 1hshD-2rf7A:
undetectable
1hshD-2rf7A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE


(Methanocaldococcus
jannaschii)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 ALA A 294
GLY A 288
ILE A 289
ILE A 122
ILE A 295
None
1.27A 1hshD-2rgwA:
undetectable
1hshD-2rgwA:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
7 ARG A   8
ASP A  25
ALA A  28
GLY A  49
ILE A  50
PRO A  81
ILE A  84
AB1  A 501 ( 4.7A)
AB1  A 501 (-2.4A)
AB1  A 501 (-3.5A)
AB1  A 501 (-3.5A)
AB1  A 501 (-3.8A)
AB1  A 501 (-4.2A)
AB1  A 501 ( 4.2A)
0.48A 1hshD-2rkfA:
18.7
1hshD-2rkfA:
49.49