SIMILAR PATTERNS OF AMINO ACIDS FOR 1HSH_C_MK1C402_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a05 | 3-ISOPROPYLMALATEDEHYDROGENASE (Acidithiobacillusferrooxidans) |
PF00180(Iso_dh) | 4 | ALA A 290GLY A 260ILE A 259ILE A 16 | None | 0.69A | 1hshD-1a05A:0.0 | 1hshD-1a05A:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aec | ACTINIDIN (Actinidiachinensis) |
PF00112(Peptidase_C1) | 5 | ALA A 30GLY A 36ILE A 37ILE A 83ILE A 31 | None | 1.43A | 1hshD-1aecA:0.6 | 1hshD-1aecA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bou | 4,5-DIOXYGENASE BETACHAIN (Sphingomonaspaucimobilis) |
PF02900(LigB) | 4 | ALA B 175GLY B 169ILE B 148ILE B 106 | None | 0.69A | 1hshD-1bouB:0.0 | 1hshD-1bouB:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ddz | CARBONIC ANHYDRASE (Porphyridiumpurpureum) |
PF00484(Pro_CA) | 5 | ALA A 410GLY A 402ILE A 401ILE A 114ILE A 414 | None | 1.46A | 1hshD-1ddzA:0.0 | 1hshD-1ddzA:12.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dkg | MOLECULAR CHAPERONEDNAK (Escherichiacoli) |
PF00012(HSP70) | 5 | ALA D 153GLY D 158ILE D 160ILE D 69ILE D 73 | None | 0.76A | 1hshD-1dkgD:undetectable | 1hshD-1dkgD:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eth | TRIACYLGLYCEROLACYL-HYDROLASE (Sus scrofa) |
PF00151(Lipase)PF01477(PLAT) | 5 | ALA A 272GLY A 309ILE A 203ILE A 74ILE A 90 | None | 1.11A | 1hshD-1ethA:0.0 | 1hshD-1ethA:12.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g68 | BETA-LACTAMASE PSE-4 (Pseudomonasaeruginosa) |
PF13354(Beta-lactamase2) | 5 | ALA A 248GLY A 283ILE A 286PRO A 226ILE A 231 | None | 1.17A | 1hshD-1g68A:undetectable | 1hshD-1g68A:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gv3 | MANGANESE SUPEROXIDEDISMUTASE (Nostoc sp. PCC7120) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 4 | GLY A 27ILE A 26ILE A 230ILE A 123 | None | 0.71A | 1hshD-1gv3A:undetectable | 1hshD-1gv3A:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ALA A 28GLY A 48PRO A 81ILE A 84 | A79 A 800 (-3.2A)A79 A 800 (-4.1A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.72A | 1hshD-1hvcA:12.6 | 1hshD-1hvcA:27.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8ASP A 25GLY A 49ILE A 50PRO A 81 | A79 A 800 (-3.6A)A79 A 800 (-2.8A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A) | 0.90A | 1hshD-1hvcA:12.6 | 1hshD-1hvcA:27.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.65A | 1hshD-1hvcA:12.6 | 1hshD-1hvcA:27.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.58A | 1hshD-1hvcA:12.6 | 1hshD-1hvcA:27.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j8m | SIGNAL RECOGNITION54 KDA PROTEIN (Acidianusambivalens) |
PF00448(SRP54)PF02881(SRP54_N) | 5 | ALA F 115GLY F 149ILE F 152ILE F 183ILE F 185 | None | 0.95A | 1hshD-1j8mF:undetectable | 1hshD-1j8mF:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcz | BETA-METHYLASPARTASE (Clostridiumtetanomorphum) |
PF05034(MAAL_N)PF07476(MAAL_C) | 5 | ARG A 298ALA A 287GLY A 244ILE A 243ILE A 251 | None | 1.09A | 1hshD-1kczA:undetectable | 1hshD-1kczA:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kpl | PUTATIVE CLC FAMILY,CHLORINE TRANSPORTPROTEIN (Salmonellaenterica) |
PF00654(Voltage_CLC) | 5 | ARG A 340ALA A 370GLY A 393PRO A 321ILE A 320 | None | 1.15A | 1hshD-1kplA:undetectable | 1hshD-1kplA:12.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kz1 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (Schizosaccharomycespombe) |
PF00885(DMRL_synthase) | 5 | ALA A 150GLY A 83ILE A 84ILE A 54ILE A 20 | None | 0.81A | 1hshD-1kz1A:undetectable | 1hshD-1kz1A:25.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lo9 | 4-HYDROXYBENZOYL-COATHIOESTERASE (Pseudomonas sp.CBS3) |
no annotation | 4 | ASP A 76ALA A 72GLY A 20ILE A 11 | None | 0.69A | 1hshD-1lo9A:undetectable | 1hshD-1lo9A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2v | PROTEIN TRANSPORTPROTEIN SEC24 (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 5 | ALA B 177ILE B 628PRO B 209ILE B 207ILE B 182 | None | 1.38A | 1hshD-1m2vB:undetectable | 1hshD-1m2vB:8.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mz5 | SIALIDASE (Trypanosomarangeli) |
PF13385(Laminin_G_3)PF13859(BNR_3) | 5 | ALA A 221ILE A 197PRO A 232ILE A 243ILE A 208 | None | 1.42A | 1hshD-1mz5A:undetectable | 1hshD-1mz5A:10.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n7g | GDP-D-MANNOSE-4,6-DEHYDRATASE (Arabidopsisthaliana) |
PF16363(GDP_Man_Dehyd) | 5 | ALA A 90GLY A 57ILE A 33PRO A 107ILE A 102 | None | 1.28A | 1hshD-1n7gA:undetectable | 1hshD-1n7gA:13.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nt2 | CONSERVEDHYPOTHETICAL PROTEIN (Archaeoglobusfulgidus) |
PF01798(Nop) | 4 | ARG B 135ALA B 163GLY B 158ILE B 142 | None | 0.71A | 1hshD-1nt2B:undetectable | 1hshD-1nt2B:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oh2 | SUCROSE SPECIFICPORIN (Salmonellaenterica) |
PF02264(LamB) | 5 | ARG Q 338ALA Q 356GLY Q 109ILE Q 108ILE Q 195 | None | 0.94A | 1hshD-1oh2Q:undetectable | 1hshD-1oh2Q:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pd1 | PROTEIN TRANSPORTPROTEIN SEC24 (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 5 | ALA A 177ILE A 628PRO A 209ILE A 207ILE A 182 | None | 1.36A | 1hshD-1pd1A:undetectable | 1hshD-1pd1A:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ppr | PERIDININ-CHLOROPHYLL PROTEIN (Amphidiniumcarterae) |
PF02429(PCP) | 4 | GLY M 71ILE M 73ILE M 207ILE M 211 | NonePID M 614 (-4.4A)PID M 612 (-4.1A)CLA M 601 (-4.1A) | 0.72A | 1hshD-1pprM:undetectable | 1hshD-1pprM:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pz3 | ALPHA-L-ARABINOFURANOSIDASE (Geobacillusstearothermophilus) |
PF06964(Alpha-L-AF_C) | 4 | ALA A 121ILE A 57ILE A 28ILE A 68 | None | 0.68A | 1hshD-1pz3A:undetectable | 1hshD-1pz3A:10.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1n | HYPOTHETICALZINC-TYPE ALCOHOLDEHYDROGENASE-LIKEPROTEIN IN PRE5-FET4INTERGENIC REGION (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ALA A 201GLY A 223ILE A 321ILE A 319 | None | 0.64A | 1hshD-1q1nA:undetectable | 1hshD-1q1nA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q3x | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 5 | ALA A 468GLY A 635ILE A 652ILE A 536ILE A 462 | None | 0.95A | 1hshD-1q3xA:undetectable | 1hshD-1q3xA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8y | SR PROTEIN KINASE (Saccharomycescerevisiae) |
PF00069(Pkinase) | 4 | ARG A 287ASP A 282ALA A 697GLY A 726 | None | 0.71A | 1hshD-1q8yA:undetectable | 1hshD-1q8yA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rif | DNA HELICASE UVSW (Escherichiavirus T4) |
PF04851(ResIII) | 5 | ALA A 237GLY A 257ILE A 132ILE A 246ILE A 242 | NoneNone AU A 287 ( 4.7A)NoneNone | 1.48A | 1hshD-1rifA:undetectable | 1hshD-1rifA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rj6 | CARBONIC ANHYDRASEXIV (Mus musculus) |
PF00194(Carb_anhydrase) | 5 | ARG A 254GLY A 145PRO A 30ILE A 31ILE A 33 | None | 1.19A | 1hshD-1rj6A:undetectable | 1hshD-1rj6A:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rpn | GDP-MANNOSE4,6-DEHYDRATASE (Pseudomonasaeruginosa) |
PF16363(GDP_Man_Dehyd) | 4 | ARG A 45ALA A 19GLY A 9ILE A 53 | NoneNoneNDP A1501 (-3.3A)None | 0.72A | 1hshD-1rpnA:undetectable | 1hshD-1rpnA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rrm | LACTALDEHYDEREDUCTASE (Escherichiacoli) |
PF00465(Fe-ADH) | 5 | ARG A 120ALA A 106GLY A 80ILE A 74ILE A 154 | None | 1.25A | 1hshD-1rrmA:undetectable | 1hshD-1rrmA:15.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 8 | ARG A 8ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 82ILE A 84 | None | 0.62A | 1hshD-1sivA:20.8 | 1hshD-1sivA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ARG A 8GLY A 51ILE A 50PRO A 81ILE A 82 | None | 1.45A | 1hshD-1sivA:20.8 | 1hshD-1sivA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 4 | ASP A 25ALA A 28GLY A 48ILE A 84 | None | 0.66A | 1hshD-1sivA:20.8 | 1hshD-1sivA:86.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1squ | CHEX PROTEIN (Thermotogamaritima) |
PF13690(CheX) | 5 | ALA A 101GLY A 50ILE A 52ILE A 46ILE A 113 | None | 1.39A | 1hshD-1squA:undetectable | 1hshD-1squA:26.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1swf | CIRCULARLY PERMUTEDCORE-STREPTAVIDINE51/A46 (Streptomycesavidinii) |
PF01382(Avidin) | 5 | ALA A 33GLY A 41ILE A 30ILE A 104ILE A 17 | None | 1.38A | 1hshD-1swfA:undetectable | 1hshD-1swfA:25.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tez | DEOXYRIBODIPYRIMIDINE PHOTOLYASE (Synechococcuselongatus) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 5 | ALA A 336GLY A 330PRO A 408ILE A 354ILE A 333 | None | 1.31A | 1hshD-1tezA:undetectable | 1hshD-1tezA:11.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to6 | GLYCERATE KINASE (Neisseriameningitidis) |
PF02595(Gly_kinase) | 5 | ALA A 334GLY A 317ILE A 337PRO A 7ILE A 283 | None | 1.29A | 1hshD-1to6A:undetectable | 1hshD-1to6A:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tv8 | MOLYBDENUM COFACTORBIOSYNTHESIS PROTEINA (Staphylococcusaureus) |
PF04055(Radical_SAM)PF06463(Mob_synth_C)PF13394(Fer4_14) | 5 | ARG A 17ALA A 59GLY A 66ILE A 13ILE A 70 | None | 1.05A | 1hshD-1tv8A:undetectable | 1hshD-1tv8A:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1typ | TRYPANOTHIONEREDUCTASE (Crithidiafasciculata) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 442GLY A 426ILE A 415ILE A 437ILE A 438 | None | 1.48A | 1hshD-1typA:undetectable | 1hshD-1typA:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xfg | GLUCOSAMINE--FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE[ISOMERIZING] (Escherichiacoli) |
PF13522(GATase_6) | 4 | ARG A 22ALA A 6GLY A 183ILE A 15 | None | 0.55A | 1hshD-1xfgA:undetectable | 1hshD-1xfgA:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xks | NUCLEAR PORE COMPLEXPROTEIN NUP133 (Homo sapiens) |
no annotation | 5 | ALA A 178ILE A 221PRO A 234ILE A 240ILE A 184 | None | 1.47A | 1hshD-1xksA:undetectable | 1hshD-1xksA:13.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xt5 | VARIABLEREGION-CONTAININGCHITIN-BINDINGPROTEIN 3 (Branchiostomafloridae) |
PF07686(V-set) | 5 | ALA A 124GLY A 121ILE A 116PRO A 37ILE A 39 | None | 1.44A | 1hshD-1xt5A:undetectable | 1hshD-1xt5A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y0e | PUTATIVEN-ACETYLMANNOSAMINE-6-PHOSPHATE2-EPIMERASE (Staphylococcusaureus) |
PF04131(NanE) | 5 | ALA A 28GLY A 38ILE A 7ILE A 47ILE A 50 | None | 0.99A | 1hshD-1y0eA:undetectable | 1hshD-1y0eA:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y7e | PROBABLE M18-FAMILYAMINOPEPTIDASE 1 (Borreliellaburgdorferi) |
PF02127(Peptidase_M18) | 4 | ILE A 221PRO A 107ILE A 117ILE A 194 | None | 0.70A | 1hshD-1y7eA:undetectable | 1hshD-1y7eA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y7w | HALOTOLERANTALPHA-TYPE CARBONICANHYDRASE (DCA II) (Dunaliellasalina) |
PF00194(Carb_anhydrase) | 5 | ALA A 210GLY A 155PRO A 38ILE A 39ILE A 41 | None | 1.37A | 1hshD-1y7wA:undetectable | 1hshD-1y7wA:14.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y7w | HALOTOLERANTALPHA-TYPE CARBONICANHYDRASE (DCA II) (Dunaliellasalina) |
PF00194(Carb_anhydrase) | 5 | ARG A 269ALA A 210GLY A 155ILE A 39ILE A 41 | None | 0.92A | 1hshD-1y7wA:undetectable | 1hshD-1y7wA:14.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yf2 | TYPE IRESTRICTION-MODIFICATION ENZYME, SSUBUNIT (Methanocaldococcusjannaschii) |
PF01420(Methylase_S) | 4 | ALA A 94GLY A 117ILE A 118ILE A 59 | None | 0.67A | 1hshD-1yf2A:undetectable | 1hshD-1yf2A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ygp | YEAST GLYCOGENPHOSPHORYLASE (Saccharomycescerevisiae) |
PF00343(Phosphorylase) | 5 | ALA A 695GLY A 485ILE A 486ILE A 703ILE A 699 | None | 1.28A | 1hshD-1ygpA:undetectable | 1hshD-1ygpA:9.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yxy | PUTATIVEN-ACETYLMANNOSAMINE-6-PHOSPHATE2-EPIMERASE (Streptococcuspyogenes) |
PF04131(NanE) | 5 | ALA A 42GLY A 52ILE A 19ILE A 61ILE A 64 | None | 0.95A | 1hshD-1yxyA:undetectable | 1hshD-1yxyA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3z | DIALKYLGLYCINEDECARBOXYLASE (Burkholderiacepacia) |
PF00202(Aminotran_3) | 5 | ALA A 428GLY A 379ILE A 395ILE A 351ILE A 429 | None | 1.35A | 1hshD-1z3zA:undetectable | 1hshD-1z3zA:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zch | HYPOTHETICALOXIDOREDUCTASE YCND (Bacillussubtilis) |
PF00881(Nitroreductase) | 5 | ALA A 73GLY A 131ILE A 14PRO A 134ILE A 135 | NoneNoneNoneFMN A 301 (-4.0A)FMN A 301 (-3.8A) | 1.25A | 1hshD-1zchA:undetectable | 1hshD-1zchA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjk | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 5 | ALA A 468GLY A 635ILE A 652ILE A 536ILE A 462 | None | 0.95A | 1hshD-1zjkA:undetectable | 1hshD-1zjkA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a00 | POTASSIUM-TRANSPORTING ATPASE B CHAIN (Escherichiacoli) |
no annotation | 4 | GLY A 385ILE A 393ILE A 443ILE A 352 | None | 0.66A | 1hshD-2a00A:undetectable | 1hshD-2a00A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aqw | PUTATIVEOROTIDINE-MONOPHOSPHATE-DECARBOXYLASE (Plasmodiumyoelii) |
PF00215(OMPdecase) | 4 | ALA A 248GLY A 268ILE A 269ILE A 264 | NoneSO4 A2002 ( 4.9A)NoneNone | 0.69A | 1hshD-2aqwA:undetectable | 1hshD-2aqwA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2av5 | RIBONUCLEASE PPROTEIN COMPONENT 2 (Pyrococcusfuriosus) |
PF01900(RNase_P_Rpp14) | 5 | ARG A 71ALA A 20ILE A 38ILE A 59ILE A 69 | None | 1.28A | 1hshD-2av5A:undetectable | 1hshD-2av5A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3x | IRON-RESPONSIVEELEMENT BINDINGPROTEIN 1 (Homo sapiens) |
PF00330(Aconitase)PF00694(Aconitase_C) | 5 | ALA A 46ILE A 235PRO A 240ILE A 39ILE A 63 | None | 1.26A | 1hshD-2b3xA:undetectable | 1hshD-2b3xA:7.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4w | HYPOTHETICALPROTEIN, CONSERVED (Leishmaniamajor) |
PF08950(DUF1861) | 5 | ALA A 266GLY A 245ILE A 243PRO A 296ILE A 206 | None | 1.21A | 1hshD-2b4wA:undetectable | 1hshD-2b4wA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5m | DAMAGE-SPECIFIC DNABINDING PROTEIN 1 (Homo sapiens) |
PF03178(CPSF_A)PF10433(MMS1_N) | 5 | ASP A 275GLY A 233ILE A 232PRO A 250ILE A 252 | None | 1.24A | 1hshD-2b5mA:undetectable | 1hshD-2b5mA:8.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bp5 | CLATHRIN COATASSEMBLY PROTEINAP50 (Rattusnorvegicus) |
PF00928(Adap_comp_sub) | 5 | ALA M 194GLY M 429PRO M 396ILE M 284ILE M 283 | None | 1.21A | 1hshD-2bp5M:undetectable | 1hshD-2bp5M:13.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cjq | RNA-DIRECTED RNAPOLYMERASE (Pestivirus A) |
PF00998(RdRP_3) | 4 | GLY A 362ILE A 361ILE A 298ILE A 380 | None | 0.72A | 1hshD-2cjqA:undetectable | 1hshD-2cjqA:9.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ddt | SPHINGOMYELINPHOSPHODIESTERASE (Bacillus cereus) |
PF03372(Exo_endo_phos) | 5 | GLY A 193ILE A 192PRO A 223ILE A 267ILE A 303 | None | 1.35A | 1hshD-2ddtA:undetectable | 1hshD-2ddtA:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dht | 409AA LONGHYPOTHETICALNADP-DEPENDENTISOCITRATEDEHYDROGENASE (Sulfurisphaeratokodaii) |
PF00180(Iso_dh) | 5 | ARG A 215GLY A 305ILE A 308ILE A 146ILE A 147 | None | 1.37A | 1hshD-2dhtA:undetectable | 1hshD-2dhtA:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3z | BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF00232(Glyco_hydro_1) | 5 | ALA A 208GLY A 225ILE A 166PRO A 171ILE A 201 | None | 1.49A | 1hshD-2e3zA:undetectable | 1hshD-2e3zA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ew7 | PEPTIDE DEFORMYLASE (Helicobacterpylori) |
PF01327(Pep_deformylase) | 5 | ALA A 128ILE A 84PRO A 81ILE A 140ILE A 136 | None | 1.27A | 1hshD-2ew7A:undetectable | 1hshD-2ew7A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2a | ASPARTYL/GLUTAMYL-TRNA(ASN/GLN)AMIDOTRANSFERASESUBUNIT B (Staphylococcusaureus) |
PF02637(GatB_Yqey)PF02934(GatB_N) | 5 | GLY B 103ILE B 118PRO B 98ILE B 99ILE B 70 | None | 1.03A | 1hshD-2f2aB:undetectable | 1hshD-2f2aB:14.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f31 | DIAPHANOUS PROTEINHOMOLOG 1 (Mus musculus) |
PF06367(Drf_FH3)PF06371(Drf_GBD) | 4 | ALA A 238GLY A 231ILE A 232ILE A 209 | None | 0.67A | 1hshD-2f31A:undetectable | 1hshD-2f31A:17.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 6 | ARG A 8ASP A 25ALA A 28GLY A 55PRO A 86ILE A 89 | LP1 A 201 (-3.5A)LP1 A 201 (-2.3A)LP1 A 201 (-3.5A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.55A | 1hshD-2fmbA:15.9 | 1hshD-2fmbA:37.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 4 | ASP A 25ALA A 28GLY A 54ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)LP1 A 201 (-4.2A) | 0.71A | 1hshD-2fmbA:15.9 | 1hshD-2fmbA:37.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fq1 | ISOCHORISMATASE (Escherichiacoli) |
PF00550(PP-binding)PF00857(Isochorismatase) | 5 | GLY A 242ILE A 239PRO A 232ILE A 273ILE A 222 | MG A 997 (-4.4A)NoneNoneNoneNone | 1.42A | 1hshD-2fq1A:undetectable | 1hshD-2fq1A:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fvz | INOSITOLMONOPHOSPHATASE 2 (Homo sapiens) |
PF00459(Inositol_P) | 5 | GLY A 31ILE A 33PRO A 102ILE A 100ILE A 120 | None | 1.32A | 1hshD-2fvzA:undetectable | 1hshD-2fvzA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fwr | DNA REPAIR PROTEINRAD25 (Archaeoglobusfulgidus) |
PF04851(ResIII)PF16203(ERCC3_RAD25_C) | 4 | ARG A 327ALA A 309GLY A 294ILE A 295 | None | 0.70A | 1hshD-2fwrA:undetectable | 1hshD-2fwrA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g2d | ATP:COBALAMINADENOSYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF01923(Cob_adeno_trans) | 5 | ARG A 164ALA A 73ILE A 66ILE A 97ILE A 92 | None | 1.48A | 1hshD-2g2dA:undetectable | 1hshD-2g2dA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g36 | TRYPTOPHANYL-TRNASYNTHETASE (Thermotogamaritima) |
PF00579(tRNA-synt_1b) | 4 | ALA A 134ILE A 128ILE A 97ILE A 161 | None | 0.65A | 1hshD-2g36A:undetectable | 1hshD-2g36A:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gmu | PUTATIVEPYRIDOXAMINE5-PHOSPHATE-DEPENDENT DEHYDRASE, WBDK (Escherichiacoli) |
PF01041(DegT_DnrJ_EryC1) | 5 | ASP A 106ALA A 85GLY A 336ILE A 109ILE A 107 | None | 1.18A | 1hshD-2gmuA:undetectable | 1hshD-2gmuA:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gzl | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Escherichiacoli) |
PF02542(YgbB) | 5 | ALA A 40ILE A 99PRO A 103ILE A 18ILE A 20 | None | 1.42A | 1hshD-2gzlA:undetectable | 1hshD-2gzlA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hig | 6-PHOSPHO-1-FRUCTOKINASE (Trypanosomabrucei) |
PF00365(PFK) | 4 | GLY A 123ILE A 124ILE A 116ILE A 102 | None | 0.63A | 1hshD-2higA:undetectable | 1hshD-2higA:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hmf | PROBABLEASPARTOKINASE (Methanocaldococcusjannaschii) |
PF00696(AA_kinase)PF01842(ACT)PF13840(ACT_7) | 5 | ALA A 276GLY A 218ILE A 217ILE A 228ILE A 283 | None | 1.24A | 1hshD-2hmfA:undetectable | 1hshD-2hmfA:13.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hoe | N-ACETYLGLUCOSAMINEKINASE (Thermotogamaritima) |
PF00480(ROK) | 5 | ALA A 214GLY A 189ILE A 349ILE A 308ILE A 206 | None | 1.28A | 1hshD-2hoeA:undetectable | 1hshD-2hoeA:14.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hr7 | INSULIN RECEPTOR (Homo sapiens) |
PF00757(Furin-like)PF01030(Recep_L_domain) | 4 | ALA A 92ILE A 119ILE A 136ILE A 112 | None | 0.66A | 1hshD-2hr7A:undetectable | 1hshD-2hr7A:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j6h | GLUCOSAMINE-FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE (Escherichiacoli) |
PF01380(SIS)PF13522(GATase_6) | 4 | ARG A 22ALA A 6GLY A 183ILE A 15 | None | 0.55A | 1hshD-2j6hA:undetectable | 1hshD-2j6hA:9.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kho | HEAT SHOCK PROTEIN70 (Escherichiacoli) |
PF00012(HSP70) | 5 | ALA A 153GLY A 158ILE A 160ILE A 69ILE A 73 | None | 0.79A | 1hshD-2khoA:undetectable | 1hshD-2khoA:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mt9 | FLAVODOXIN-2 (Escherichiacoli) |
PF00258(Flavodoxin_1) | 5 | ALA A 17GLY A 86ILE A 53ILE A 50ILE A 21 | None | 1.15A | 1hshD-2mt9A:undetectable | 1hshD-2mt9A:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nad | NAD-DEPENDENTFORMATEDEHYDROGENASE (Pseudomonas sp.101) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | ALA A 140GLY A 121ILE A 122PRO A 37ILE A 351 | NoneAZI A 395 (-3.6A)NAD A 394 ( 3.5A)NoneNone | 1.16A | 1hshD-2nadA:undetectable | 1hshD-2nadA:14.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyf | NOSTOC PUNCTIFORMEPHENYLALANINEAMMONIA LYASE (Nostocpunctiforme) |
PF00221(Lyase_aromatic) | 4 | ALA A 220ILE A 177ILE A 144ILE A 139 | None | 0.63A | 1hshD-2nyfA:undetectable | 1hshD-2nyfA:10.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o14 | HYPOTHETICAL PROTEINYXIM (Bacillussubtilis) |
PF13472(Lipase_GDSL_2) | 4 | ALA A 270ILE A 262ILE A 224ILE A 228 | None | 0.67A | 1hshD-2o14A:undetectable | 1hshD-2o14A:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oca | ATP-DEPENDENT DNAHELICASE UVSW (Escherichiavirus T4) |
PF00271(Helicase_C)PF04851(ResIII) | 5 | ALA A 237GLY A 257ILE A 132ILE A 246ILE A 242 | None | 1.48A | 1hshD-2ocaA:undetectable | 1hshD-2ocaA:12.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oca | ATP-DEPENDENT DNAHELICASE UVSW (Escherichiavirus T4) |
PF00271(Helicase_C)PF04851(ResIII) | 5 | ALA A 267ILE A 51PRO A 61ILE A 246ILE A 242 | None | 1.45A | 1hshD-2ocaA:undetectable | 1hshD-2ocaA:12.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ols | PHOSPHOENOLPYRUVATESYNTHASE (Neisseriameningitidis) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 5 | ALA A 738GLY A 698ILE A 677ILE A 771ILE A 739 | None | 1.16A | 1hshD-2olsA:undetectable | 1hshD-2olsA:8.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pft | EXOCYTOSIS PROTEIN (Mus musculus) |
PF03081(Exo70) | 5 | ALA A 492ILE A 530PRO A 594ILE A 593ILE A 493 | None | 1.29A | 1hshD-2pftA:undetectable | 1hshD-2pftA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pgw | MUCONATECYCLOISOMERASE (Sinorhizobiummeliloti) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 49ILE A 305PRO A 272ILE A 313ILE A 278 | None | 1.09A | 1hshD-2pgwA:undetectable | 1hshD-2pgwA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pwz | MALATE DEHYDROGENASE (Escherichiacoli) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ALA A 128GLY A 306ILE A 303PRO A 120ILE A 116 | None | 1.50A | 1hshD-2pwzA:undetectable | 1hshD-2pwzA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3f | RAS-RELATEDGTP-BINDING PROTEIND (Homo sapiens) |
PF04670(Gtr1_RagA) | 5 | ALA A 121GLY A 118ILE A 115ILE A 96ILE A 46 | None | 1.22A | 1hshD-2q3fA:undetectable | 1hshD-2q3fA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qk4 | TRIFUNCTIONAL PURINEBIOSYNTHETIC PROTEINADENOSINE-3 (Homo sapiens) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | ALA A 18GLY A 12PRO A 74ILE A 8ILE A 7 | NoneNoneSO4 A 701 (-4.8A)NoneNone | 1.15A | 1hshD-2qk4A:undetectable | 1hshD-2qk4A:13.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qua | EXTRACELLULAR LIPASE (Serratiamarcescens) |
no annotation | 5 | ARG A 454ALA A 447GLY A 392ILE A 381ILE A 450 | NoneNone CA A 619 (-4.2A)NoneNone | 1.24A | 1hshD-2quaA:undetectable | 1hshD-2quaA:10.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qua | EXTRACELLULAR LIPASE (Serratiamarcescens) |
no annotation | 5 | ARG A 454ALA A 447GLY A 392ILE A 416ILE A 450 | NoneNone CA A 619 (-4.2A)NoneNone | 1.32A | 1hshD-2quaA:undetectable | 1hshD-2quaA:10.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rf7 | CYTOCHROME C-552 (Escherichiacoli) |
PF02335(Cytochrom_C552) | 5 | ALA A 80GLY A 445PRO A 432ILE A 434ILE A 77 | None | 1.35A | 1hshD-2rf7A:undetectable | 1hshD-2rf7A:13.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rgw | ASPARTATECARBAMOYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | ALA A 294GLY A 288ILE A 289ILE A 122ILE A 295 | None | 1.27A | 1hshD-2rgwA:undetectable | 1hshD-2rgwA:16.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | AB1 A 501 ( 4.7A)AB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.48A | 1hshD-2rkfA:18.7 | 1hshD-2rkfA:49.49 |