SIMILAR PATTERNS OF AMINO ACIDS FOR 1HSH_A_MK1A401_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dkg | MOLECULAR CHAPERONEDNAK (Escherichiacoli) |
PF00012(HSP70) | 5 | ALA D 153GLY D 158ILE D 160ILE D 69ILE D 73 | None | 0.73A | 1hshB-1dkgD:undetectable | 1hshB-1dkgD:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fhu | O-SUCCINYLBENZOATESYNTHASE (Escherichiacoli) |
PF13378(MR_MLE_C) | 5 | ALA A 175ILE A 186VAL A 146ILE A 210ILE A 208 | None | 0.88A | 1hshB-1fhuA:undetectable | 1hshB-1fhuA:15.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fxj | UDP-N-ACETYLGLUCOSAMINEPYROPHOSPHORYLASE (Escherichiacoli) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 5 | ILE A 202GLY A 127ILE A 174ILE A 198ILE A 201 | ILE A 202 ( 0.7A)GLY A 127 ( 0.0A)ILE A 174 ( 0.7A)ILE A 198 ( 0.4A)ILE A 201 ( 0.6A) | 0.94A | 1hshB-1fxjA:undetectable | 1hshB-1fxjA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gll | GLYCEROL KINASE (Escherichiacoli) |
no annotation | 5 | ALA Y 444GLY Y 241ILE Y 79ILE Y 74ILE Y 6 | None | 0.97A | 1hshB-1gllY:undetectable | 1hshB-1gllY:12.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpl | RP2 LIPASE (Cavia porcellus) |
PF00151(Lipase)PF01477(PLAT) | 6 | ASP A 195ILE A 148VAL A 128GLY A 125ILE A 121ILE A 172 | CA A 500 (-2.3A)NoneNoneNoneNoneNone | 1.50A | 1hshB-1gplA:undetectable | 1hshB-1gplA:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hcy | ARTHROPODANHEMOCYANIN (Panulirusinterruptus) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | ILE A 305GLY A 320ILE A 321ILE A 296ILE A 327 | None | 0.90A | 1hshB-1hcyA:undetectable | 1hshB-1hcyA:9.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hf2 | SEPTUMSITE-DETERMININGPROTEIN MINC (Thermotogamaritima) |
PF03775(MinC_C) | 5 | ALA A 134ILE A 148ILE A 121ILE A 108ILE A 132 | None | 0.92A | 1hshB-1hf2A:undetectable | 1hshB-1hf2A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.60A | 1hshB-1hvcA:12.6 | 1hshB-1hvcA:27.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.61A | 1hshB-1hvcA:12.6 | 1hshB-1hvcA:27.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kz1 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (Schizosaccharomycespombe) |
PF00885(DMRL_synthase) | 5 | ALA A 150GLY A 83ILE A 84ILE A 54ILE A 20 | None | 0.93A | 1hshB-1kz1A:undetectable | 1hshB-1kz1A:25.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1n | GENOME POLYPROTEIN:PICORNAIN 3C (Enterovirus C) |
PF00548(Peptidase_C3) | 5 | ILE A 49VAL A 16ILE A 36ILE A 56ILE A 47 | None | 0.90A | 1hshB-1l1nA:undetectable | 1hshB-1l1nA:25.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lm5 | SUBDOMAIN OFDESMOPLAKINCARBOXY-TERMINALDOMAIN (DPCT) (Homo sapiens) |
PF00681(Plectin) | 5 | ALA A2805ILE A2631GLY A2640ILE A2633ILE A2622 | None | 0.88A | 1hshB-1lm5A:undetectable | 1hshB-1lm5A:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rfz | HYPOTHETICAL PROTEINAPC35681 (Geobacillusstearothermophilus) |
PF04608(PgpA) | 5 | ILE A 104GLY A 67ILE A 68ILE A 55ILE A 149 | None | 0.95A | 1hshB-1rfzA:undetectable | 1hshB-1rfzA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rvv | RIBOFLAVIN SYNTHASE (Bacillussubtilis) |
no annotation | 5 | ALA A 34ILE A 15VAL A 43ILE A 112ILE A 76 | None | 0.84A | 1hshB-1rvvA:undetectable | 1hshB-1rvvA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sei | RIBOSOMAL PROTEIN S8 (Geobacillusstearothermophilus) |
PF00410(Ribosomal_S8) | 5 | ILE A 31VAL A 1ILE A 125ILE A 38ILE A 35 | None | 0.90A | 1hshB-1seiA:undetectable | 1hshB-1seiA:20.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ILE A 32GLY A 48PRO A 81ILE A 82ILE A 84 | None | 0.75A | 1hshB-1sivA:20.4 | 1hshB-1sivA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 9 | ASP A 25ALA A 28ILE A 32VAL A 47GLY A 49ILE A 50PRO A 81ILE A 82ILE A 84 | None | 0.76A | 1hshB-1sivA:20.4 | 1hshB-1sivA:86.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wky | ENDO-BETA-1,4-MANNANASE (Bacillus sp.JAMB-602) |
PF00150(Cellulase) | 5 | ALA A 175ILE A 190VAL A 209ILE A 153ILE A 155 | None | 0.83A | 1hshB-1wkyA:undetectable | 1hshB-1wkyA:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aam | HYPOTHETICAL PROTEINTM1410 (Thermotogamaritima) |
PF03537(Glyco_hydro_114) | 5 | ILE A 92ILE A 180PRO A 201ILE A 199ILE A 186 | None | 0.89A | 1hshB-2aamA:undetectable | 1hshB-2aamA:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bty | ACETYLGLUTAMATEKINASE (Thermotogamaritima) |
PF00696(AA_kinase) | 5 | ILE A 165GLY A 169ILE A 170ILE A 152ILE A 120 | None | 0.77A | 1hshB-2btyA:undetectable | 1hshB-2btyA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f31 | DIAPHANOUS PROTEINHOMOLOG 1 (Mus musculus) |
PF06367(Drf_FH3)PF06371(Drf_GBD) | 5 | ALA A 238ILE A 208GLY A 231ILE A 232ILE A 209 | None | 0.82A | 1hshB-2f31A:undetectable | 1hshB-2f31A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9g | MITOGEN-ACTIVATEDPROTEIN KINASE FUS3 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 5 | ALA A 269ILE A 239ILE A 283ILE A 222ILE A 238 | None | 0.94A | 1hshB-2f9gA:undetectable | 1hshB-2f9gA:16.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | ASP A 25ALA A 28GLY A 55PRO A 86ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.5A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.45A | 1hshB-2fmbA:15.7 | 1hshB-2fmbA:37.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h7g | DNA TOPOISOMERASE 1 (Variola virus) |
PF01028(Topoisom_I)PF09266(VirDNA-topo-I_N) | 5 | ILE X 217VAL X 94ILE X 102ILE X 219ILE X 212 | None | 0.96A | 1hshB-2h7gX:undetectable | 1hshB-2h7gX:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijd | PICORNAIN 3C,RNA-DIRECTED RNAPOLYMERASE (Enterovirus C) |
PF00548(Peptidase_C3)PF00680(RdRP_1) | 5 | ILE 1 49VAL 1 16ILE 1 36ILE 1 56ILE 1 47 | None | 0.94A | 1hshB-2ijd1:undetectable | 1hshB-2ijd1:10.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iu8 | UDP-3-O-[3-HYDROXYMYRISTOYL] GLUCOSAMINEN-ACYLTRANSFERASE (Chlamydiatrachomatis) |
PF00132(Hexapep)PF04613(LpxD) | 5 | ALA A 279ILE A 257VAL A 243ILE A 287ILE A 275 | None | 0.95A | 1hshB-2iu8A:undetectable | 1hshB-2iu8A:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kho | HEAT SHOCK PROTEIN70 (Escherichiacoli) |
PF00012(HSP70) | 5 | ALA A 153GLY A 158ILE A 160ILE A 69ILE A 73 | None | 0.78A | 1hshB-2khoA:undetectable | 1hshB-2khoA:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oi6 | BIFUNCTIONAL PROTEINGLMU (Escherichiacoli) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 5 | ILE A 202GLY A 127ILE A 174ILE A 198ILE A 201 | None | 0.93A | 1hshB-2oi6A:undetectable | 1hshB-2oi6A:11.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ood | BLR3880 PROTEIN (Bradyrhizobiumdiazoefficiens) |
PF01979(Amidohydro_1) | 5 | ALA A 47VAL A 61GLY A 7ILE A 8ILE A 54 | None | 0.97A | 1hshB-2oodA:undetectable | 1hshB-2oodA:13.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 28ILE A 32GLY A 48PRO A 81ILE A 84 | AB1 A 501 (-3.5A)AB1 A 501 (-4.5A)AB1 A 501 (-4.2A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.78A | 1hshB-2rkfA:18.6 | 1hshB-2rkfA:49.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ILE A 32VAL A 47GLY A 49ILE A 50PRO A 81ILE A 84 | AB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-4.5A)AB1 A 501 ( 4.9A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.57A | 1hshB-2rkfA:18.6 | 1hshB-2rkfA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yvt | HYPOTHETICAL PROTEINAQ_1956 (Aquifexaeolicus) |
PF14582(Metallophos_3) | 5 | GLY A 138ILE A 179PRO A 213ILE A 208ILE A 207 | None | 0.93A | 1hshB-2yvtA:undetectable | 1hshB-2yvtA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clj | PROTEIN NRD1 (Saccharomycescerevisiae) |
PF04818(CTD_bind) | 5 | ILE A 51VAL A 104ILE A 98ILE A 46ILE A 50 | None | 0.92A | 1hshB-3cljA:undetectable | 1hshB-3cljA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dcl | TM1086 (Thermotogamaritima) |
PF14505(DUF4438) | 6 | ALA A 175ILE A 198VAL A 241GLY A 239ILE A 238ILE A 177 | None | 1.20A | 1hshB-3dclA:undetectable | 1hshB-3dclA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dto | BH2835 PROTEIN (Bacillushalodurans) |
PF01966(HD) | 5 | ALA A 54ILE A 100ILE A 30ILE A 61ILE A 97 | None | 0.96A | 1hshB-3dtoA:undetectable | 1hshB-3dtoA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4e | CYTOCHROME P450 2E1 (Homo sapiens) |
PF00067(p450) | 5 | ALA A 438ILE A 115GLY A 300ILE A 180ILE A 114 | HEM A 500 (-3.8A)HEM A 500 (-4.0A)HEM A 500 (-3.4A)NoneHEM A 500 (-4.0A) | 0.94A | 1hshB-3e4eA:undetectable | 1hshB-3e4eA:11.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eg4 | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-SUCCINYLTRANSFERASE (Brucella suis) |
PF00132(Hexapep)PF14602(Hexapep_2)PF14805(THDPS_N_2) | 5 | ALA A 157ILE A 185VAL A 197GLY A 170ILE A 159 | None | 0.95A | 1hshB-3eg4A:undetectable | 1hshB-3eg4A:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f5f | MALTOSE-BINDINGPERIPLASMIC PROTEIN,HEPARAN SULFATE2-O-SULFOTRANSFERASE1 (Escherichiacoli;Gallus gallus) |
PF03567(Sulfotransfer_2)PF13416(SBP_bac_8) | 6 | ALA A 276ILE A 9VAL A 35ILE A 2ILE A 60ILE A 59 | None | 1.49A | 1hshB-3f5fA:undetectable | 1hshB-3f5fA:11.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fch | CARBOXYSOME SHELLPROTEIN CSOS1D (Prochlorococcusmarinus) |
PF00936(BMC) | 5 | ALA A 206ILE A 253VAL A 60GLY A 201ILE A 250 | None | 0.92A | 1hshB-3fchA:undetectable | 1hshB-3fchA:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g25 | GLYCEROL KINASE (Staphylococcusaureus) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ALA A 443GLY A 240ILE A 78ILE A 73ILE A 5 | None | 0.86A | 1hshB-3g25A:undetectable | 1hshB-3g25A:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gc2 | O-SUCCINYLBENZOATESYNTHASE (Salmonellaenterica) |
PF13378(MR_MLE_C) | 5 | ALA A 175ILE A 186VAL A 146ILE A 210ILE A 208 | None | 0.85A | 1hshB-3gc2A:undetectable | 1hshB-3gc2A:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gfa | PUTATIVENITROREDUCTASE (Clostridioidesdifficile) |
PF00881(Nitroreductase) | 5 | ILE A 173GLY A 32ILE A 33ILE A 25ILE A 99 | None | 0.87A | 1hshB-3gfaA:undetectable | 1hshB-3gfaA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3a | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Leptospirainterrogans) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ALA A 61ILE A 94ILE A 87ILE A 51ILE A 63 | None | 0.91A | 1hshB-3i3aA:undetectable | 1hshB-3i3aA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3it4 | ARGININEBIOSYNTHESISBIFUNCTIONAL PROTEINARGJ ALPHA CHAIN (Mycobacteriumtuberculosis) |
PF01960(ArgJ) | 5 | ALA A 40VAL A 16GLY A 157PRO A 171ILE A 164 | None | 0.94A | 1hshB-3it4A:undetectable | 1hshB-3it4A:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k92 | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Bacillussubtilis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | ALA A 245ILE A 298VAL A 212ILE A 226ILE A 224 | None | 0.90A | 1hshB-3k92A:undetectable | 1hshB-3k92A:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lac | PYRROLIDONE-CARBOXYLATE PEPTIDASE (Bacillusanthracis) |
PF01470(Peptidase_C15) | 5 | ILE A 79GLY A 163ILE A 65ILE A 193ILE A 166 | None | 0.95A | 1hshB-3lacA:undetectable | 1hshB-3lacA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mp7 | PREPROTEINTRANSLOCASE SUBUNITSECY (Pyrococcusfuriosus) |
PF00344(SecY)PF10559(Plug_translocon) | 5 | ILE A 290VAL A 65GLY A 435ILE A 436ILE A 289 | None | 0.90A | 1hshB-3mp7A:undetectable | 1hshB-3mp7A:12.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.70A | 1hshB-3mwsA:19.2 | 1hshB-3mwsA:48.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oai | MALTOSE-BINDINGPERIPLASMIC PROTEIN,MYELIN PROTEIN P0 (Escherichiacoli;Homo sapiens) |
PF07686(V-set)PF13416(SBP_bac_8) | 6 | ALA A 276ILE A 9VAL A 35ILE A 2ILE A 60ILE A 59 | None | 1.48A | 1hshB-3oaiA:undetectable | 1hshB-3oaiA:11.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ob4 | MALTOSE ABCTRANSPORTERPERIPLASMIC PROTEIN,ARAH 2 (Arachisduranensis;Escherichiacoli) |
PF00234(Tryp_alpha_amyl)PF13416(SBP_bac_8) | 6 | ALA A 276ILE A 9VAL A 35ILE A 2ILE A 60ILE A 59 | None | 1.45A | 1hshB-3ob4A:undetectable | 1hshB-3ob4A:13.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qml | 78 KDAGLUCOSE-REGULATEDPROTEIN HOMOLOG (Saccharomycescerevisiae) |
PF00012(HSP70) | 5 | ALA A 203GLY A 208ILE A 210ILE A 116ILE A 120 | None | 0.78A | 1hshB-3qmlA:undetectable | 1hshB-3qmlA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sti | PROTEASE DEGQ (Escherichiacoli) |
PF13365(Trypsin_2) | 5 | ALA A 25VAL A 144GLY A 189ILE A 129ILE A 127 | None | 0.82A | 1hshB-3stiA:undetectable | 1hshB-3stiA:25.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ILE A 32VAL A 47GLY A 49ILE A 50PRO A 81ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-3.4A)None017 A 201 ( 4.9A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.67A | 1hshB-3ttpA:19.2 | 1hshB-3ttpA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ILE A 32GLY A 49ILE A 50PRO A 81 | 017 A 202 ( 2.5A)017 A 201 (-3.4A)None017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.60A | 1hshB-3u7sA:19.1 | 1hshB-3u7sA:47.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vnp | HYPOTHETICALCONSERVED PROTEIN (Geobacilluskaustophilus) |
PF00132(Hexapep) | 5 | ILE A 102VAL A 83GLY A 97ILE A 126ILE A 108 | None | 0.97A | 1hshB-3vnpA:undetectable | 1hshB-3vnpA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ao7 | ESTERASE (unidentified) |
PF12146(Hydrolase_4) | 5 | ALA A 125VAL A 26ILE A 119PRO A 82ILE A 79 | None | 0.96A | 1hshB-4ao7A:undetectable | 1hshB-4ao7A:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ddq | DNA GYRASE SUBUNIT A (Bacillussubtilis) |
PF00521(DNA_topoisoIV) | 5 | ALA A 233GLY A 215ILE A 213ILE A 183ILE A 332 | None | 0.93A | 1hshB-4ddqA:undetectable | 1hshB-4ddqA:12.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dlo | BRAIN-SPECIFICANGIOGENESISINHIBITOR 3 (Homo sapiens) |
PF01825(GPS)PF02793(HRM)PF16489(GAIN) | 5 | ILE A 741VAL A 790GLY A 763ILE A 706ILE A 718 | None | 0.96A | 1hshB-4dloA:undetectable | 1hshB-4dloA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e1j | GLYCEROL KINASE (Sinorhizobiummeliloti) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ALA A 467GLY A 262ILE A 101ILE A 96ILE A 28 | None | 0.93A | 1hshB-4e1jA:undetectable | 1hshB-4e1jA:11.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e6u | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Acinetobacterbaumannii) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ALA A 17ILE A 37ILE A 30ILE A 7ILE A 19 | None | 0.95A | 1hshB-4e6uA:undetectable | 1hshB-4e6uA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4c | MULTIDRUG RESISTANCEPROTEIN PGP-1 (Caenorhabditiselegans) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | ALA A1190ILE A1174VAL A1182ILE A1169ILE A1173 | None | 0.93A | 1hshB-4f4cA:undetectable | 1hshB-4f4cA:5.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdd | TRANSPORTIN-1 (Homo sapiens) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 6 | ALA A 423ILE A 398VAL A 305GLY A 417ILE A 418ILE A 424 | None | 1.15A | 1hshB-4fddA:undetectable | 1hshB-4fddA:9.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1g | MALTOSE BINDINGPROTEIN-CAKAR3 MOTORDOMAIN FUSIONPROTEIN (Candidaalbicans;Escherichiacoli) |
PF00225(Kinesin)PF13416(SBP_bac_8) | 6 | ALA A -94ILE A-361VAL A-335ILE A-368ILE A-310ILE A-311 | None | 1.43A | 1hshB-4h1gA:undetectable | 1hshB-4h1gA:10.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h4a | MITOCHONDRIALCARDIOLIPINHYDROLASE (Drosophilamelanogaster) |
PF13091(PLDc_2) | 5 | ALA A 103ILE A 123ILE A 174ILE A 96ILE A 100 | None | 0.95A | 1hshB-4h4aA:undetectable | 1hshB-4h4aA:26.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifp | MALTOSE-BINDINGPERIPLASMICPROTEIN,NACHT, LRRAND PYDDOMAINS-CONTAININGPROTEIN 1 (Escherichiacoli;Homo sapiens) |
PF00619(CARD)PF13416(SBP_bac_8) | 6 | ALA A 277ILE A 10VAL A 36ILE A 3ILE A 61ILE A 60 | None | 1.48A | 1hshB-4ifpA:undetectable | 1hshB-4ifpA:12.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iig | BETA-GLUCOSIDASE 1 (Aspergillusaculeatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | ALA A 127ILE A 392GLY A 96ILE A 97PRO A 457 | None | 0.96A | 1hshB-4iigA:undetectable | 1hshB-4iigA:7.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ikm | MALTOSE-BINDINGPERIPLASMIC PROTEIN,CASPASE RECRUITMENTDOMAIN-CONTAININGPROTEIN 8 (Escherichiacoli;Homo sapiens) |
PF00619(CARD)PF13416(SBP_bac_8) | 6 | ALA A 277ILE A 10VAL A 36ILE A 3ILE A 61ILE A 60 | None | 1.48A | 1hshB-4ikmA:undetectable | 1hshB-4ikmA:13.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iwn | TRNA(CMO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF13649(Methyltransf_25) | 5 | ALA A 126ILE A 150ILE A 85ILE A 121ILE A 123 | None | 0.97A | 1hshB-4iwnA:undetectable | 1hshB-4iwnA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jg5 | PUTATIVE CELLADHESION PROTEIN (Parabacteroidesdistasonis) |
PF06321(P_gingi_FimA) | 5 | ALA A 300ILE A 326VAL A 281ILE A 215ILE A 358 | None | 0.93A | 1hshB-4jg5A:undetectable | 1hshB-4jg5A:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jjp | PHOSPHOMETHYLPYRIMIDINE KINASE (Clostridioidesdifficile) |
PF08543(Phos_pyr_kin) | 5 | ILE A 88GLY A 13ILE A 22ILE A 66ILE A 92 | None | 0.89A | 1hshB-4jjpA:undetectable | 1hshB-4jjpA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jjp | PHOSPHOMETHYLPYRIMIDINE KINASE (Clostridioidesdifficile) |
PF08543(Phos_pyr_kin) | 6 | ILE A 88VAL A 83GLY A 13ILE A 22ILE A 61ILE A 62 | None | 1.27A | 1hshB-4jjpA:undetectable | 1hshB-4jjpA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lsm | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE,CYTOSOLIC (Trypanosomacruzi) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | ALA A 27ILE A 11VAL A 332ILE A 38ILE A 35 | None | 0.80A | 1hshB-4lsmA:undetectable | 1hshB-4lsmA:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4my2 | MALTOSE-BINDINGPERIPLASMIC PROTEIN,NORRIN FUSIONPROTEIN (Escherichiacoli;Homo sapiens) |
PF00007(Cys_knot)PF13416(SBP_bac_8) | 6 | ALA A 278ILE A 11VAL A 37ILE A 4ILE A 62ILE A 61 | None | 1.46A | 1hshB-4my2A:undetectable | 1hshB-4my2A:12.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | RIT A 500 (-2.4A)RIT A 500 (-3.6A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.61A | 1hshB-4njvA:18.2 | 1hshB-4njvA:47.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nky | STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) |
PF00067(p450) | 5 | ILE A 179GLY A 444ILE A 446ILE A 145ILE A 182 | NoneHEM A 600 ( 3.7A)NoneNoneNone | 0.81A | 1hshB-4nkyA:undetectable | 1hshB-4nkyA:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nuf | MALTOSE ABCTRANSPORTERPERIPLASMIC PROTEIN,NUCLEAR RECEPTORSUBFAMILY 0 GROUP BMEMBER 2 CHIMERICCONSTRUCT (Escherichiacoli;Mus musculus) |
PF00104(Hormone_recep)PF13416(SBP_bac_8) | 6 | ALA A 278ILE A 11VAL A 37ILE A 4ILE A 62ILE A 61 | None | 1.47A | 1hshB-4nufA:undetectable | 1hshB-4nufA:10.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ose | PUTATIVE HYDROLASE (Rickettsiatyphi) |
PF00561(Abhydrolase_1) | 5 | ALA A 122ILE A 234GLY A 115ILE A 116ILE A 230 | None | 0.90A | 1hshB-4oseA:undetectable | 1hshB-4oseA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ox2 | PHOSPHOENOLPYRUVATECARBOXYKINASE,CYTOSOLIC [GTP] (Rattusnorvegicus) |
PF00821(PEPCK_C)PF17297(PEPCK_N) | 5 | ALA A 281VAL A 308GLY A 269ILE A 270ILE A 428 | None | 0.73A | 1hshB-4ox2A:undetectable | 1hshB-4ox2A:10.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmw | DIS3-LIKEEXONUCLEASE 2 (Mus musculus) |
PF00773(RNB)PF17216(Rrp44_CSD1) | 5 | ALA A 231ILE A 85VAL A 111PRO A 88ILE A 94 | None | 0.95A | 1hshB-4pmwA:undetectable | 1hshB-4pmwA:8.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9i | SERPIN-18 (Bombyx mori) |
PF00079(Serpin) | 5 | ALA A 234ILE A 282VAL A 255GLY A 257ILE A 236 | None | 0.95A | 1hshB-4r9iA:undetectable | 1hshB-4r9iA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xxk | PHYCOBILIPROTEINAPCE (Nostoc sp. PCC7120) |
PF00502(Phycobilisome) | 5 | ALA A 204GLY A 198ILE A 192ILE A 79ILE A 75 | NoneNoneCYC A 301 (-4.3A)NoneNone | 0.95A | 1hshB-4xxkA:undetectable | 1hshB-4xxkA:22.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | ASP A 32ALA A 35VAL A 56GLY A 58ILE A 100 | 4B1 A 201 (-2.9A)4B1 A 201 (-3.6A)None4B1 A 201 (-3.4A)4B1 A 201 (-4.8A) | 0.60A | 1hshB-4ydfA:13.2 | 1hshB-4ydfA:35.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yxm | DNA INTEGRITYSCANNING PROTEINDISA (Thermotogamaritima) |
PF00633(HHH)PF02457(DisA_N)PF10635(DisA-linker) | 5 | ALA A 301ILE A 321GLY A 308ILE A 307ILE A 343 | None | 0.92A | 1hshB-4yxmA:undetectable | 1hshB-4yxmA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a5g | FORMATE--TETRAHYDROFOLATE LIGASE (Tepidanaerobacteracetatoxydans) |
PF01268(FTHFS) | 5 | ALA A 379VAL A 410GLY A 418ILE A 58ILE A 327 | None | 0.81A | 1hshB-5a5gA:undetectable | 1hshB-5a5gA:10.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 28ILE A 32VAL A 47PRO A 81ILE A 84 | None | 0.76A | 1hshB-5b18A:18.2 | 1hshB-5b18A:47.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cr9 | ABC-TYPEFE3+-HYDROXAMATETRANSPORT SYSTEM,PERIPLASMICCOMPONENT (Saccharomonosporaviridis) |
PF01497(Peripla_BP_2) | 5 | ALA A 85ILE A 124VAL A 132GLY A 134ILE A 119 | None | 0.74A | 1hshB-5cr9A:undetectable | 1hshB-5cr9A:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f42 | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Francisellatularensis) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ALA A 60ILE A 93ILE A 86ILE A 50ILE A 62 | None | 0.83A | 1hshB-5f42A:undetectable | 1hshB-5f42A:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fji | BETA-GLUCOSIDASE (Aspergillusfumigatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | ALA A 128ILE A 393GLY A 97ILE A 98PRO A 458 | None | 0.94A | 1hshB-5fjiA:undetectable | 1hshB-5fjiA:6.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5in2 | EXTRACELLULARSUPEROXIDE DISMUTASE[CU-ZN] (Onchocercavolvulus) |
PF00080(Sod_Cu) | 5 | ALA A 95VAL A 14GLY A 16ILE A 17ILE A 87 | None | 0.90A | 1hshB-5in2A:undetectable | 1hshB-5in2A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxx | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Moraxellacatarrhalis) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ALA A 13ILE A 33ILE A 26ILE A 3ILE A 15 | None | 0.94A | 1hshB-5jxxA:undetectable | 1hshB-5jxxA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n3u | PHYCOCYANOBILINLYASE SUBUNIT ALPHA (Nostoc sp. PCC7120) |
no annotation | 5 | ALA A 185ILE A 164GLY A 159ILE A 158ILE A 167 | None | 0.77A | 1hshB-5n3uA:undetectable | 1hshB-5n3uA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5npy | FLAGELLAR BASAL BODYPROTEIN (Helicobacterpylori) |
no annotation | 5 | VAL A 144GLY A 146ILE A 147ILE A 152ILE A 179 | None | 0.94A | 1hshB-5npyA:undetectable | 1hshB-5npyA:12.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 22ILE A 66GLY A 86ILE A 15ILE A 13 | None | 0.89A | 1hshB-5t2zA:18.7 | 1hshB-5t2zA:49.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.69A | 1hshB-5t2zA:18.7 | 1hshB-5t2zA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tj2 | SUGAR ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN,GASDERMIN-BFUSION PROTEIN (Escherichiacoli;Homo sapiens) |
PF04598(Gasdermin)PF13416(SBP_bac_8) | 6 | ALA A 276ILE A 9VAL A 35ILE A 2ILE A 60ILE A 59 | None | 1.45A | 1hshB-5tj2A:undetectable | 1hshB-5tj2A:10.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1j | THIOREDOXINGLUTATHIONEREDUCTASE (Echinococcusgranulosus) |
no annotation | 5 | ALA A 125ILE A 254GLY A 448ILE A 445ILE A 114 | None | 0.90A | 1hshB-5w1jA:undetectable | 1hshB-5w1jA:11.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dm8 | - (-) |
no annotation | 6 | ALA A 61ILE A-206VAL A-180ILE A-213ILE A-155ILE A-156 | None | 1.44A | 1hshB-6dm8A:undetectable | 1hshB-6dm8A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fkh | ATP SYNTHASE EPSILONCHAIN, CHLOROPLASTIC (Spinaciaoleracea) |
no annotation | 5 | ILE e 69GLY e 32ILE e 23ILE e 76ILE e 74 | None | 0.86A | 1hshB-6fkhe:undetectable | 1hshB-6fkhe:24.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ILE A 32VAL A 47GLY A 49ILE A 50PRO A 81ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-3.6A)NoneNoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)NoneNone | 0.68A | 1hshB-6upjA:18.8 | 1hshB-6upjA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ILE A 32VAL A 47GLY A 49PRO A 81ILE A 82ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-3.6A)NoneNoneNIU A 100 ( 3.8A)NoneNIU A 100 (-4.6A)None | 0.69A | 1hshB-6upjA:18.8 | 1hshB-6upjA:98.99 |