SIMILAR PATTERNS OF AMINO ACIDS FOR 1HSH_A_MK1A401_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 6 | GLY B 452ALA B 432ASP B 433ILE B 86GLY B 429ILE B 88 | None | 1.49A | 1hshA-1e9yB:undetectable | 1hshA-1e9yB:10.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efv | ELECTRON TRANSFERFLAVOPROTEIN (Homo sapiens) |
PF00766(ETF_alpha)PF01012(ETF) | 6 | ALA A 305ASP A 302ILE A 280ILE A 315ILE A 296ILE A 307 | FAD A 599 ( 4.2A)NoneFAD A 599 (-4.3A)NoneNoneNone | 1.42A | 1hshA-1efvA:undetectable | 1hshA-1efvA:15.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fue | FLAVODOXIN (Helicobacterpylori) |
PF00258(Flavodoxin_1) | 6 | GLY A 85ALA A 52VAL A 34ILE A 6ILE A 81ILE A 103 | None | 1.35A | 1hshA-1fueA:undetectable | 1hshA-1fueA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gt9 | KUMAMOLYSIN (Bacillussubtilis) |
PF00082(Peptidase_S8) | 6 | GLY 1 92ALA 1 93ILE 1 124PRO 1 282ILE 1 30ILE 1 28 | None | 1.40A | 1hshA-1gt91:undetectable | 1hshA-1gt91:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 28ASP A 29GLY A 48PRO A 81ILE A 84 | A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 (-4.1A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.77A | 1hshA-1hvcA:12.7 | 1hshA-1hvcA:27.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29GLY A 48ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 (-3.6A)A79 A 800 (-3.6A) | 0.74A | 1hshA-1hvcA:12.7 | 1hshA-1hvcA:27.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 4.9A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.53A | 1hshA-1hvcA:12.7 | 1hshA-1hvcA:27.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 ( 4.7A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.47A | 1hshA-1hvcA:12.7 | 1hshA-1hvcA:27.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1llu | ALCOHOLDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | GLY A 239ALA A 237ILE A 254PRO A 226ILE A 200ILE A 230 | None | 1.35A | 1hshA-1lluA:undetectable | 1hshA-1lluA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lm5 | SUBDOMAIN OFDESMOPLAKINCARBOXY-TERMINALDOMAIN (DPCT) (Homo sapiens) |
PF00681(Plectin) | 5 | ALA A2805ILE A2631GLY A2640ILE A2633ILE A2622 | None | 0.80A | 1hshA-1lm5A:undetectable | 1hshA-1lm5A:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nfg | D-HYDANTOINASE (Ralstoniapickettii) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 6 | GLY A 431ALA A 388ILE A 382GLY A 22ILE A 4ILE A 390 | None | 1.24A | 1hshA-1nfgA:undetectable | 1hshA-1nfgA:11.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o2d | ALCOHOLDEHYDROGENASE,IRON-CONTAINING (Thermotogamaritima) |
PF00465(Fe-ADH) | 6 | GLY A 139ALA A 190ASP A 189GLY A 244ILE A 217ILE A 218 | NoneNone FE A 900 ( 2.5A)NoneNoneNone | 1.35A | 1hshA-1o2dA:undetectable | 1hshA-1o2dA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 5 | VAL A 117GLY A 115ILE A 208ILE A 165ILE A 172 | NoneNoneNAG A 801 ( 4.7A)NoneNone | 0.83A | 1hshA-1q5aA:undetectable | 1hshA-1q5aA:8.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30PRO A 81ILE A 84 | None | 0.81A | 1hshA-1q9pA:10.1 | 1hshA-1q9pA:49.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rp0 | THIAZOLEBIOSYNTHETIC ENZYME (Arabidopsisthaliana) |
PF01946(Thi4) | 5 | GLY A 194ALA A 195ILE A 246VAL A 238GLY A 240 | NoneNoneNoneNoneAHZ A 600 (-3.5A) | 0.71A | 1hshA-1rp0A:undetectable | 1hshA-1rp0A:17.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ASP A 29GLY A 49ILE A 50PRO A 81ILE A 82ILE A 84 | None | 1.24A | 1hshA-1sivA:20.2 | 1hshA-1sivA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 12 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32VAL A 47GLY A 49ILE A 50PRO A 81ILE A 82ILE A 84 | None | 0.57A | 1hshA-1sivA:20.2 | 1hshA-1sivA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 29ILE A 32GLY A 48PRO A 81ILE A 82ILE A 84 | None | 0.80A | 1hshA-1sivA:20.2 | 1hshA-1sivA:86.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7w | COENZYME ABIOSYNTHESISBIFUNCTIONAL PROTEINCOABC (Escherichiacoli) |
PF04127(DFP) | 6 | GLY A 228ALA A 229ILE A 270VAL A 397ILE A 193ILE A 191 | None | 1.28A | 1hshA-1u7wA:undetectable | 1hshA-1u7wA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vc4 | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Thermusthermophilus) |
PF00218(IGPS) | 6 | ALA A 232ASP A 231VAL A 177GLY A 179ILE A 180ILE A 49 | None | 1.12A | 1hshA-1vc4A:undetectable | 1hshA-1vc4A:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vgw | 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHASE (Neisseriagonorrhoeae) |
PF01128(IspD) | 5 | GLY A 173ALA A 172ASP A 103ILE A 6ILE A 105 | None | 0.86A | 1hshA-1vgwA:undetectable | 1hshA-1vgwA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w85 | PYRUVATEDEHYDROGENASE E1COMPONENT, BETASUBUNIT (Geobacillusstearothermophilus) |
PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ILE B 168VAL B 136PRO B 166ILE B 112ILE B 114 | None | 0.88A | 1hshA-1w85B:undetectable | 1hshA-1w85B:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wky | ENDO-BETA-1,4-MANNANASE (Bacillus sp.JAMB-602) |
PF00150(Cellulase) | 5 | ALA A 175ILE A 190VAL A 209ILE A 153ILE A 155 | None | 0.79A | 1hshA-1wkyA:undetectable | 1hshA-1wkyA:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xe1 | HYPOTHETICAL PROTEINPF0907 (Pyrococcusfuriosus) |
PF14578(GTP_EFTU_D4) | 6 | GLY A 66ASP A 41ILE A 43VAL A 97ILE A 86ILE A 88 | None | 1.32A | 1hshA-1xe1A:undetectable | 1hshA-1xe1A:26.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7s | HUMAN COXSACKIEVIRUSA21 (Enterovirus C) |
PF00073(Rhv) | 6 | GLY 2 188ALA 2 190ILE 2 127VAL 2 230GLY 2 123ILE 2 197 | None | 1.39A | 1hshA-1z7s2:undetectable | 1hshA-1z7s2:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2au1 | IGG-DEGRADINGPROTEASE (Streptococcuspyogenes) |
PF09028(Mac-1) | 5 | GLY A 268ALA A 269ASP A 270VAL A 298ILE A 239 | None | 0.85A | 1hshA-2au1A:undetectable | 1hshA-2au1A:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b0r | POSSIBLE ADENYLCYCLASE-ASSOCIATEDPROTEIN (Cryptosporidiumparvum) |
PF08603(CAP_C) | 5 | ILE A 94VAL A 87ILE A 103ILE A 115ILE A 113 | None | 0.87A | 1hshA-2b0rA:undetectable | 1hshA-2b0rA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bc0 | NADH OXIDASE (Streptococcuspyogenes) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 453ALA A 454ASP A 456ILE A 387ILE A 426 | None | 0.83A | 1hshA-2bc0A:undetectable | 1hshA-2bc0A:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cy8 | D-PHENYLGLYCINEAMINOTRANSFERASE (Pseudomonasstutzeri) |
PF00202(Aminotran_3) | 5 | ALA A 129VAL A 286GLY A 282ILE A 113ILE A 239 | None | 0.85A | 1hshA-2cy8A:undetectable | 1hshA-2cy8A:11.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2czd | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Pyrococcushorikoshii) |
PF00215(OMPdecase) | 6 | GLY A 76ALA A 77ASP A 41ILE A 42ILE A 70ILE A 43 | None | 1.35A | 1hshA-2czdA:undetectable | 1hshA-2czdA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f31 | DIAPHANOUS PROTEINHOMOLOG 1 (Mus musculus) |
PF06367(Drf_FH3)PF06371(Drf_GBD) | 5 | ALA A 238ILE A 208GLY A 231ILE A 232ILE A 209 | None | 0.86A | 1hshA-2f31A:undetectable | 1hshA-2f31A:17.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 29GLY A 54ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)LP1 A 201 (-3.6A)LP1 A 201 (-4.2A) | 0.80A | 1hshA-2fmbA:15.6 | 1hshA-2fmbA:37.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29GLY A 55PRO A 86ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.30A | 1hshA-2fmbA:15.6 | 1hshA-2fmbA:37.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g5t | DIPEPTIDYL PEPTIDASE4 (Homo sapiens) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | ASP A 136ILE A 143ILE A 176ILE A 148ILE A 134 | None | 0.72A | 1hshA-2g5tA:undetectable | 1hshA-2g5tA:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i8l | HYDROGENASE 3MATURATION PROTEASE (Escherichiacoli) |
PF01750(HycI) | 6 | GLY A 19ALA A 18ASP A 16ILE A 60ILE A 73ILE A 113 | None | 1.21A | 1hshA-2i8lA:undetectable | 1hshA-2i8lA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iht | CARBOXYETHYLARGININESYNTHASE (Streptomycesclavuligerus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 6 | GLY A 462ALA A 461ASP A 409VAL A 407ILE A 388ILE A 555 | TPP A 600 (-3.4A)NoneNoneNoneNoneNone | 1.32A | 1hshA-2ihtA:undetectable | 1hshA-2ihtA:10.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | GLY A 190ALA A 189GLY A 183ILE A 180PRO A 296 | NoneNonePLP A 400 (-3.4A)PLP A 400 (-4.9A)PLP A 400 (-4.0A) | 0.73A | 1hshA-2isqA:undetectable | 1hshA-2isqA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pa6 | ENOLASE (Methanocaldococcusjannaschii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 6 | GLY A 177ALA A 178ILE A 181VAL A 185GLY A 188ILE A 173 | None | 1.40A | 1hshA-2pa6A:undetectable | 1hshA-2pa6A:13.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po2 | PROBABLE EXOSOMECOMPLEX EXONUCLEASE2 (Pyrococcusabyssi) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 5 | ALA B 159VAL B 194GLY B 154ILE B 153ILE B 38 | None | 0.84A | 1hshA-2po2B:undetectable | 1hshA-2po2B:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ptz | ENOLASE (Trypanosomabrucei) |
PF00113(Enolase_C)PF03952(Enolase_N) | 6 | GLY A 199ALA A 202ASP A 201PRO A 221ILE A 224ILE A 194 | None | 1.46A | 1hshA-2ptzA:undetectable | 1hshA-2ptzA:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qm3 | PREDICTEDMETHYLTRANSFERASE (Pyrococcusfuriosus) |
PF01861(DUF43) | 5 | GLY A 195ASP A 198ILE A 174GLY A 169ILE A 163 | None | 0.83A | 1hshA-2qm3A:undetectable | 1hshA-2qm3A:14.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ALA A 28ASP A 29ILE A 32GLY A 48PRO A 81ILE A 84 | AB1 A 501 (-3.5A)AB1 A 501 ( 3.3A)AB1 A 501 (-4.5A)AB1 A 501 (-4.2A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.82A | 1hshA-2rkfA:18.8 | 1hshA-2rkfA:49.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 11 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32VAL A 47GLY A 49ILE A 50PRO A 81ILE A 84 | AB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.5A)AB1 A 501 ( 3.3A)AB1 A 501 (-3.8A)AB1 A 501 (-4.5A)AB1 A 501 ( 4.9A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.47A | 1hshA-2rkfA:18.8 | 1hshA-2rkfA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rsp | RSV PROTEASE (Rous sarcomavirus) |
PF00077(RVP) | 6 | ASP A 37GLY A 39ALA A 40ASP A 41ILE A 44ILE A 108 | None | 0.46A | 1hshA-2rspA:12.5 | 1hshA-2rspA:29.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3j | CARBOHYDRATE BINDINGMODULE (unculturedbacterium) |
PF16990(CBM_35) | 6 | GLY A 60ASP A 32ILE A 31GLY A 29ILE A 124ILE A 121 | None CA A1138 (-3.3A)None CA A1139 (-4.4A)NoneNone | 1.40A | 1hshA-2w3jA:undetectable | 1hshA-2w3jA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxe | PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF01135(PCMT) | 5 | GLY A 140ASP A 136GLY A 85ILE A 131ILE A 133 | None | 0.84A | 1hshA-2yxeA:undetectable | 1hshA-2yxeA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bio | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Porphyromonasgingivalis) |
PF01408(GFO_IDH_MocA)PF16654(DAPDH_C) | 6 | GLY A 35ALA A 10ILE A 82VAL A 68GLY A 13ILE A 57 | None | 1.12A | 1hshA-3bioA:undetectable | 1hshA-3bioA:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwc | PUTATIVE GLYCERATEKINASE 2 (Salmonellaenterica) |
PF02595(Gly_kinase) | 6 | GLY A 251ALA A 250VAL A 194GLY A 246ILE A 131ILE A 133 | None | 1.17A | 1hshA-3cwcA:undetectable | 1hshA-3cwcA:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3czq | PUTATIVEPOLYPHOSPHATE KINASE2 (Sinorhizobiummeliloti) |
PF03976(PPK2) | 5 | GLY A 99ALA A 100ILE A 254ILE A 197ILE A 195 | GOL A 303 (-4.3A)NoneNoneNoneNone | 0.77A | 1hshA-3czqA:undetectable | 1hshA-3czqA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ep1 | PGRP-HD -PEPTIDOGLYCANRECOGNITION PROTEINHOMOLOGUE (Alvinellapompejana) |
PF01510(Amidase_2) | 6 | GLY A 221ALA A 222ILE A 184GLY A 212ILE A 210ILE A 102 | None | 1.21A | 1hshA-3ep1A:undetectable | 1hshA-3ep1A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f6m | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Yersinia pestis) |
PF02542(YgbB) | 6 | GLY A 39ASP A 8GLY A 147PRO A 105ILE A 27ILE A 22 | None | 1.20A | 1hshA-3f6mA:undetectable | 1hshA-3f6mA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f6m | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Yersinia pestis) |
PF02542(YgbB) | 6 | GLY A 39ASP A 8ILE A 100GLY A 147PRO A 105ILE A 22 | None | 1.22A | 1hshA-3f6mA:undetectable | 1hshA-3f6mA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gla | LOW MOLECULAR WEIGHTHEAT SHOCK PROTEIN (Xanthomonascitri) |
PF00011(HSP20) | 5 | ASP A 118GLY A 76ILE A 77ILE A 131ILE A 120 | None | 0.81A | 1hshA-3glaA:undetectable | 1hshA-3glaA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdf | LYSOZYME (Escherichiavirus Lambda) |
PF00959(Phage_lysozyme) | 6 | ALA A 131ASP A 127GLY A 163PRO A 95ILE A 94ILE A 123 | None | 1.32A | 1hshA-3hdfA:undetectable | 1hshA-3hdfA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hkz | DNA-DIRECTED RNAPOLYMERASE SUBUNITA' (Sulfolobussolfataricus) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | GLY A 712ALA A 711ILE A 665GLY A 748ILE A 661 | None | 0.86A | 1hshA-3hkzA:undetectable | 1hshA-3hkzA:7.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5g | MYOSIN HEAVY CHAINISOFORM A (Doryteuthispealeii) |
PF00063(Myosin_head)PF00612(IQ)PF02736(Myosin_N) | 6 | GLY A 264ALA A 265ASP A 266GLY A 460ILE A 459ILE A 224 | None | 0.98A | 1hshA-3i5gA:undetectable | 1hshA-3i5gA:8.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jsk | CYPBP37 PROTEIN (Neurosporacrassa) |
PF01946(Thi4) | 5 | GLY A 254ALA A 255ILE A 306VAL A 298GLY A 300 | AHZ A 500 ( 4.3A)NoneNoneNoneAHZ A 500 (-3.5A) | 0.76A | 1hshA-3jskA:undetectable | 1hshA-3jskA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jsk | CYPBP37 PROTEIN (Neurosporacrassa) |
PF01946(Thi4) | 6 | GLY A 323ALA A 94ILE A 109VAL A 170ILE A 82ILE A 84 | None | 1.44A | 1hshA-3jskA:undetectable | 1hshA-3jskA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k92 | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Bacillussubtilis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 6 | GLY A 244ALA A 245ILE A 298VAL A 212ILE A 226ILE A 224 | None | 1.02A | 1hshA-3k92A:undetectable | 1hshA-3k92A:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kw3 | ALANINE RACEMASE (Bartonellahenselae) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | GLY A 299ILE A 283VAL A 336ILE A 339ILE A 319 | None | 0.82A | 1hshA-3kw3A:undetectable | 1hshA-3kw3A:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3la4 | UREASE (Canavaliaensiformis) |
PF00449(Urease_alpha)PF00547(Urease_gamma)PF00699(Urease_beta)PF01979(Amidohydro_1) | 6 | GLY A 723ALA A 703ASP A 704ILE A 357GLY A 700ILE A 359 | None | 1.44A | 1hshA-3la4A:undetectable | 1hshA-3la4A:8.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mp7 | PREPROTEINTRANSLOCASE SUBUNITSECY (Pyrococcusfuriosus) |
PF00344(SecY)PF10559(Plug_translocon) | 5 | ILE A 290VAL A 65GLY A 435ILE A 436ILE A 289 | None | 0.82A | 1hshA-3mp7A:undetectable | 1hshA-3mp7A:12.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ALA A 28ASP A 29ASP A 30GLY A 48PRO A 81ILE A 84 | None | 0.85A | 1hshA-3mwsA:19.0 | 1hshA-3mwsA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 29GLY A 49ILE A 50PRO A 81 | None | 1.39A | 1hshA-3mwsA:19.0 | 1hshA-3mwsA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49PRO A 81ILE A 84 | None | 0.55A | 1hshA-3mwsA:19.0 | 1hshA-3mwsA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.64A | 1hshA-3mwsA:19.0 | 1hshA-3mwsA:48.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n9x | PHOSPHOTRANSFERASE (Plasmodiumberghei) |
PF00069(Pkinase) | 6 | GLY A 174ALA A 176ILE A 145VAL A 170ILE A 381ILE A 150 | None | 1.37A | 1hshA-3n9xA:undetectable | 1hshA-3n9xA:12.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8o | 6-PHOSPHOFRUCTOKINASE SUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00365(PFK) | 5 | GLY A 414ALA A 415ASP A 416ILE A 375ILE A 452 | None | 0.85A | 1hshA-3o8oA:undetectable | 1hshA-3o8oA:7.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLY A 269ALA A 268ILE A 331ILE A 348ILE A 330 | NAD A 501 (-3.6A)NAD A 501 ( 4.8A)NoneNAD A 501 (-4.4A)NAD A 501 (-4.8A) | 0.81A | 1hshA-3oneA:undetectable | 1hshA-3oneA:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opy | 6-PHOSPHOFRUCTO-1-KINASE ALPHA-SUBUNIT (Komagataellapastoris) |
PF00365(PFK) | 5 | GLY A 419ALA A 420ASP A 421ILE A 380ILE A 457 | None | 0.83A | 1hshA-3opyA:undetectable | 1hshA-3opyA:7.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p3v | PTS SYSTEM,N-ACETYLGALACTOSAMINE-SPECIFIC IIBCOMPONENT (Streptococcuspyogenes) |
PF03830(PTSIIB_sorb) | 6 | ALA A 35ASP A 89ILE A 70PRO A 99ILE A 6ILE A 82 | None | 1.23A | 1hshA-3p3vA:undetectable | 1hshA-3p3vA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9n | POSSIBLEMETHYLTRANSFERASE(METHYLASE) (Mycobacteriumtuberculosis) |
PF03602(Cons_hypoth95) | 5 | GLY A 93ALA A 94ILE A 82GLY A 58ILE A 86 | None | 0.86A | 1hshA-3p9nA:undetectable | 1hshA-3p9nA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pqd | L-LACTATEDEHYDROGENASE (Bacillussubtilis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 6 | GLY A 266ALA A 267ASP A 268GLY A 304ILE A 175ILE A 272 | None | 1.42A | 1hshA-3pqdA:undetectable | 1hshA-3pqdA:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q94 | FRUCTOSE-BISPHOSPHATE ALDOLASE, CLASS II (Bacillusanthracis) |
PF01116(F_bP_aldolase) | 5 | GLY A 274ILE A 34VAL A 45GLY A 21ILE A 230 | None | 0.66A | 1hshA-3q94A:undetectable | 1hshA-3q94A:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r2u | METALLO-BETA-LACTAMASE FAMILY PROTEIN (Staphylococcusaureus) |
PF00753(Lactamase_B) | 6 | ASP A 67ASP A 34ILE A 32GLY A 335ILE A 252ILE A 65 | None | 1.47A | 1hshA-3r2uA:undetectable | 1hshA-3r2uA:11.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slz | GAG-PRO-POLPOLYPROTEIN (Murine leukemiavirus) |
PF00077(RVP) | 5 | ASP A 32GLY A 34ALA A 35VAL A 54GLY A 56 | 3TL A 126 (-2.4A)3TL A 126 (-3.1A)3TL A 126 ( 4.0A)3TL A 126 (-3.3A)3TL A 126 (-3.4A) | 0.34A | 1hshA-3slzA:12.3 | 1hshA-3slzA:25.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sti | PROTEASE DEGQ (Escherichiacoli) |
PF13365(Trypsin_2) | 5 | ALA A 25VAL A 144GLY A 189ILE A 129ILE A 127 | None | 0.79A | 1hshA-3stiA:undetectable | 1hshA-3stiA:25.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)017 A 201 (-3.5A)017 A 201 (-4.2A)017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.58A | 1hshA-3t3cA:18.1 | 1hshA-3t3cA:50.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49PRO A 81 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)017 A 201 (-3.5A)017 A 201 (-4.2A)017 A 201 (-4.0A)None | 0.65A | 1hshA-3t3cA:18.1 | 1hshA-3t3cA:50.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t44 | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00218(IGPS) | 5 | ALA A 238ASP A 237VAL A 185GLY A 187ILE A 55 | None | 0.84A | 1hshA-3t44A:undetectable | 1hshA-3t44A:15.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ALA A 28ASP A 29ASP A 30ILE A 32GLY A 48ILE A 84 | 017 A 201 (-3.4A)017 A 201 (-3.3A)017 A 201 (-4.6A)NoneNone017 A 201 (-4.7A) | 0.85A | 1hshA-3ttpA:19.3 | 1hshA-3ttpA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32VAL A 47GLY A 49ILE A 50ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.4A)017 A 201 (-3.3A)017 A 201 (-4.6A)None017 A 201 ( 4.9A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.7A) | 0.64A | 1hshA-3ttpA:19.3 | 1hshA-3ttpA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32VAL A 47GLY A 49PRO A 81ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.4A)017 A 201 (-3.3A)017 A 201 (-4.6A)None017 A 201 ( 4.9A)017 A 201 (-3.0A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.51A | 1hshA-3ttpA:19.3 | 1hshA-3ttpA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32GLY A 49ILE A 50 | 017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.4A)017 A 201 (-3.2A)017 A 201 ( 4.0A)None017 A 202 (-2.9A)017 A 201 ( 3.5A) | 0.50A | 1hshA-3u7sA:19.0 | 1hshA-3u7sA:47.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32GLY A 49PRO A 81 | 017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.4A)017 A 201 (-3.2A)017 A 201 ( 4.0A)None017 A 202 (-2.9A)017 A 202 (-4.0A) | 0.41A | 1hshA-3u7sA:19.0 | 1hshA-3u7sA:47.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 29ILE A 32PRO A 81 | None | 0.53A | 1hshA-3uhlA:16.4 | 1hshA-3uhlA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uwc | NUCLEOTIDE-SUGARAMINOTRANSFERASE (Coxiellaburnetii) |
PF01041(DegT_DnrJ_EryC1) | 6 | GLY A 59ALA A 62ASP A 61ILE A 54ILE A 196ILE A 195 | PMP A 377 (-3.5A)NoneNoneNoneNoneNone | 1.42A | 1hshA-3uwcA:undetectable | 1hshA-3uwcA:13.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vcn | MANNONATEDEHYDRATASE (Caulobactervibrioides) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 33ALA A 89GLY A 292ILE A 293ILE A 67 | None | 0.80A | 1hshA-3vcnA:undetectable | 1hshA-3vcnA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aip | FE-REGULATED PROTEINB (Neisseriameningitidis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | GLY A 165ALA A 166ASP A 118GLY A 159ILE A 168 | None | 0.87A | 1hshA-4aipA:undetectable | 1hshA-4aipA:9.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ao7 | ESTERASE (unidentified) |
PF12146(Hydrolase_4) | 5 | ALA A 125VAL A 26ILE A 119PRO A 82ILE A 79 | None | 0.87A | 1hshA-4ao7A:undetectable | 1hshA-4ao7A:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4f | MANNONATEDEHYDRATASE (Pectobacteriumcarotovorum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 32ALA A 88GLY A 293ILE A 294ILE A 66 | None | 0.81A | 1hshA-4e4fA:undetectable | 1hshA-4e4fA:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g7e | UREASE (Cajanus cajan) |
PF00449(Urease_alpha)PF00547(Urease_gamma)PF00699(Urease_beta)PF01979(Amidohydro_1) | 6 | GLY B 723ALA B 703ASP B 704ILE B 357GLY B 700ILE B 359 | None | 1.47A | 1hshA-4g7eB:undetectable | 1hshA-4g7eB:10.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvl | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumthermoresistibile) |
PF00082(Peptidase_S8) | 5 | GLY A 195ALA A 196GLY A 106ILE A 188ILE A 199 | None | 0.79A | 1hshA-4hvlA:undetectable | 1hshA-4hvlA:13.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4il2 | STARVATION SENSINGPROTEIN RSPA (Escherichiacoli) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 43ALA A 99GLY A 304ILE A 305ILE A 77 | None | 0.84A | 1hshA-4il2A:undetectable | 1hshA-4il2A:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iql | ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASEII (Porphyromonasgingivalis) |
PF03060(NMO) | 5 | GLY A 43ALA A 42ILE A 83VAL A 91ILE A 79 | FMN A 401 (-4.8A)NoneNoneNoneNone | 0.84A | 1hshA-4iqlA:undetectable | 1hshA-4iqlA:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4itu | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Xanthobacterautotrophicus) |
PF13561(adh_short_C2) | 5 | GLY A 118ASP A 64GLY A 14ILE A 75ILE A 71 | NoneNAI A 301 (-3.6A)NAI A 301 (-3.3A)NoneNone | 0.86A | 1hshA-4ituA:undetectable | 1hshA-4ituA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9v | POTASSIUM UPTAKEPROTEIN TRKA (Vibrioparahaemolyticus) |
PF02080(TrkA_C)PF02254(TrkA_N) | 5 | ILE A 3VAL A 362ILE A 355ILE A 28ILE A 26 | None | 0.83A | 1hshA-4j9vA:undetectable | 1hshA-4j9vA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jjp | PHOSPHOMETHYLPYRIMIDINE KINASE (Clostridioidesdifficile) |
PF08543(Phos_pyr_kin) | 5 | ILE A 88GLY A 13ILE A 22ILE A 66ILE A 92 | None | 0.87A | 1hshA-4jjpA:undetectable | 1hshA-4jjpA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lsm | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE,CYTOSOLIC (Trypanosomacruzi) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | ALA A 27ILE A 11VAL A 332ILE A 38ILE A 35 | None | 0.87A | 1hshA-4lsmA:undetectable | 1hshA-4lsmA:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLY A 261ALA A 260ILE A 323ILE A 340ILE A 322 | NAD A 503 ( 3.8A)NAD A 503 ( 4.7A)NoneNAD A 503 (-4.3A)NAD A 503 (-4.7A) | 0.86A | 1hshA-4lvcA:undetectable | 1hshA-4lvcA:13.53 |