SIMILAR PATTERNS OF AMINO ACIDS FOR 1HRK_B_CHDB2503_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aut ACTIVATED PROTEIN C

(Homo sapiens) 		PF00008
(EGF)
PF14670
(FXa_inhibition) 		4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
 None
 1.29A 1hrkB-1autL:
undetectable		 1hrkB-1autL:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9g PROTEIN (GROWTH
FACTOR IGF-1)

(Homo sapiens) 		PF00049
(Insulin) 		4 LEU A  41
PRO A   2
LEU A  44
ARG A  21
 None
 1.34A 1hrkB-1b9gA:
undetectable		 1hrkB-1b9gA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bo6 ESTROGEN
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		4 LEU A 143
PRO A 152
LEU A 144
ARG A 257
 None
None
None
A3P  A 301 (-4.0A)
 1.19A 1hrkB-1bo6A:
undetectable		 1hrkB-1bo6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 LEU A 255
PRO A 257
LEU A 144
ARG A 534
 None
None
None
GLC  A 996 (-4.1A)
 1.39A 1hrkB-1e4oA:
0.5		 1hrkB-1e4oA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 LEU A 112
PRO A 113
LEU A 106
ARG A 108
 None
None
None
SO4  A 399 (-2.8A)
 1.39A 1hrkB-1g55A:
3.0		 1hrkB-1g55A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 LEU A 282
PRO A 283
LEU A 285
ARG A 253
 None
 1.27A 1hrkB-1hl2A:
2.1		 1hrkB-1hl2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9s MRNA CAPPING ENZYME

(Mus musculus) 		PF00782
(DSPc) 		4 LEU A  25
PRO A  26
LEU A  27
ARG A  15
 None
None
None
IPA  A 600 (-4.1A)
 1.42A 1hrkB-1i9sA:
2.2		 1hrkB-1i9sA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 LEU A 304
PRO A 275
LEU A 291
ARG A 298
 None
 1.33A 1hrkB-1kczA:
1.9		 1hrkB-1kczA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A1300
PRO A1301
LEU A1302
ARG A1311
 None
 1.18A 1hrkB-1p0cA:
3.9		 1hrkB-1p0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU A 151
PRO A 196
LEU A 414
ARG A 411
 None
 1.39A 1hrkB-1ufaA:
undetectable		 1hrkB-1ufaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdn RNA EDITING LIGASE
MP52

(Trypanosoma
brucei) 		PF09414
(RNA_ligase) 		4 LEU A 266
PRO A 267
LEU A 269
ARG A 244
 None
 1.24A 1hrkB-1xdnA:
undetectable		 1hrkB-1xdnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 LEU A  87
PRO A 206
LEU A  49
ARG A  52
 None
 1.33A 1hrkB-1xt8A:
undetectable		 1hrkB-1xt8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE

(Bos taurus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A 115
PRO A 118
LEU A 120
ARG A 123
 None
 1.23A 1hrkB-1zyeA:
2.2		 1hrkB-1zyeA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aoq DNA MISMATCH REPAIR
PROTEIN MUTH

(Haemophilus
influenzae) 		PF02976
(MutH) 		4 LEU A 207
PRO A 208
LEU A 209
ARG A 184
 None
 1.36A 1hrkB-2aoqA:
undetectable		 1hrkB-2aoqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 LEU A  44
PRO A  45
LEU A  28
ARG A  81
 None
 1.24A 1hrkB-2aw5A:
undetectable		 1hrkB-2aw5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		4 LEU A 430
PRO A 429
LEU A 433
ARG A 377
 None
 1.44A 1hrkB-2braA:
undetectable		 1hrkB-2braA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A1401 (-3.9A)
NAD  A1401 (-3.1A)
 1.26A 1hrkB-2dfvA:
2.8		 1hrkB-2dfvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2duy COMPETENCE PROTEIN
COMEA-RELATED
PROTEIN

(Thermus
thermophilus) 		PF12836
(HHH_3) 		4 LEU A  66
PRO A  63
LEU A  56
ARG A  51
 None
 1.01A 1hrkB-2duyA:
undetectable		 1hrkB-2duyA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebj PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermus
thermophilus) 		PF01470
(Peptidase_C15) 		4 LEU A  39
PRO A  40
LEU A  46
ARG A 149
 None
 1.39A 1hrkB-2ebjA:
5.0		 1hrkB-2ebjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A  96
PRO A  95
LEU A 311
ARG A 104
 None
 1.36A 1hrkB-2glxA:
2.1		 1hrkB-2glxA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		4 LEU A 500
PRO A 501
LEU A 522
ARG A 523
 None
 1.22A 1hrkB-2ktqA:
undetectable		 1hrkB-2ktqA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6a NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 12

(Homo sapiens) 		PF02758
(PYRIN) 		4 LEU A  19
PRO A  55
LEU A  27
ARG A  84
 None
 1.35A 1hrkB-2l6aA:
undetectable		 1hrkB-2l6aA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 LEU A 402
PRO A 403
LEU A 404
ARG A 271
 None
 1.15A 1hrkB-2m56A:
undetectable		 1hrkB-2m56A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		4 LEU A 313
PRO A 297
LEU A 318
ARG A 317
 None
 1.44A 1hrkB-2olaA:
undetectable		 1hrkB-2olaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A1522
PRO A1521
LEU A1564
ARG A1566
 None
 1.39A 1hrkB-2pffA:
2.4		 1hrkB-2pffA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 LEU A  93
PRO A  94
LEU A 169
ARG A 170
 None
 1.36A 1hrkB-2rdyA:
undetectable		 1hrkB-2rdyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 130
PRO A 131
LEU A 112
ARG A 118
 None
 1.22A 1hrkB-2uxtA:
undetectable		 1hrkB-2uxtA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		4 LEU A 194
PRO A 307
LEU A 207
ARG A 217
 None
 1.33A 1hrkB-2ychA:
undetectable		 1hrkB-2ychA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 LEU A 221
PRO A 130
LEU A 218
ARG A 214
 None
 1.41A 1hrkB-2zq5A:
undetectable		 1hrkB-2zq5A:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		4 LEU A 101
PRO A 102
LEU A 107
ARG A 114
 CHD  A   3 ( 4.9A)
CHD  A   3 ( 4.7A)
CHD  A   3 ( 4.6A)
CHD  A   2 (-3.6A)
 0.46A 1hrkB-3aqiA:
60.9		 1hrkB-3aqiA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 LEU A  92
PRO A  93
LEU A  95
ARG A 102
 None
 1.33A 1hrkB-3aqpA:
undetectable		 1hrkB-3aqpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		4 LEU A  56
PRO A  57
LEU A  78
ARG A 125
 None
 1.29A 1hrkB-3aytA:
undetectable		 1hrkB-3aytA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION

(Ruegeria sp.
TM1040) 		PF14563
(DUF4444)
PF16917
(BPL_LplA_LipB_2) 		4 LEU A 159
PRO A 156
LEU A  48
ARG A  49
 None
None
None
CA  A 235 ( 4.1A)
 1.35A 1hrkB-3bfmA:
undetectable		 1hrkB-3bfmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		4 LEU B  97
PRO B  98
LEU B 190
ARG B 128
 None
 0.74A 1hrkB-3bn3B:
undetectable		 1hrkB-3bn3B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD

(Chromobacterium
violaceum) 		no annotation 4 LEU A 356
PRO A 357
LEU A 319
ARG A 321
 None
 1.36A 1hrkB-3c4aA:
undetectable		 1hrkB-3c4aA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF01636
(APH) 		4 LEU A 174
PRO A 136
LEU A 139
ARG A 268
 None
None
None
EDO  A 347 ( 4.3A)
 1.30A 1hrkB-3csvA:
undetectable		 1hrkB-3csvA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 4 LEU A 184
PRO A 187
LEU A 381
ARG A 196
 None
 1.32A 1hrkB-3cv3A:
3.8		 1hrkB-3cv3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C LIGHT
CHAIN

(Homo sapiens) 		PF00008
(EGF)
PF14670
(FXa_inhibition) 		4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
 None
 1.25A 1hrkB-3f6uL:
undetectable		 1hrkB-3f6uL:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.40A 1hrkB-3fd2A:
undetectable		 1hrkB-3fd2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A 500 (-4.1A)
NAD  A 500 (-2.6A)
 1.38A 1hrkB-3gfbA:
3.2		 1hrkB-3gfbA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		4 LEU A 237
PRO A 238
LEU A 212
ARG A 272
 None
 1.34A 1hrkB-3gxoA:
3.0		 1hrkB-3gxoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A  85
PRO A  86
LEU A  87
ARG A 166
 None
 1.39A 1hrkB-3hz6A:
undetectable		 1hrkB-3hz6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A  69
PRO A  88
LEU A  66
ARG A 301
 None
 1.21A 1hrkB-3ihvA:
undetectable		 1hrkB-3ihvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		no annotation 4 LEU A 157
PRO A 156
LEU A 160
ARG A 321
 None
None
ACT  A 383 (-4.0A)
ACT  A 383 (-4.4A)
 1.43A 1hrkB-3iupA:
2.7		 1hrkB-3iupA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		PF12166
(Piezo_RRas_bdg) 		4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.39A 1hrkB-3jacA:
undetectable		 1hrkB-3jacA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb5 TRIPARTITE
MOTIF-CONTAINING
PROTEIN 72

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 LEU A 467
PRO A 466
LEU A 468
ARG A 412
 None
 1.45A 1hrkB-3kb5A:
undetectable		 1hrkB-3kb5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mip MSO-8G

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.36A 1hrkB-3mipA:
undetectable		 1hrkB-3mipA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 LEU A 722
PRO A 721
LEU A 725
ARG A 699
 None
 1.26A 1hrkB-3nowA:
undetectable		 1hrkB-3nowA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE GAMMA
CHAIN

(Escherichia
coli) 		PF00231
(ATP-synt) 		4 LEU G 190
PRO G 189
LEU G 188
ARG G 220
 None
 1.31A 1hrkB-3oaaG:
2.3		 1hrkB-3oaaG:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 LEU A  61
PRO A  62
LEU A  48
ARG A 231
 None
 1.32A 1hrkB-3p2mA:
2.4		 1hrkB-3p2mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 147
PRO A 176
LEU A  94
ARG A  96
 None
 1.37A 1hrkB-3ri6A:
2.5		 1hrkB-3ri6A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s06 MOTILITY PROTEIN B

(Helicobacter
pylori) 		PF00691
(OmpA) 		4 LEU A 119
PRO A 120
LEU A 123
ARG A 143
 None
 1.01A 1hrkB-3s06A:
undetectable		 1hrkB-3s06A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 LEU A 277
PRO A 279
LEU A 303
ARG A 297
 None
 1.23A 1hrkB-3s2uA:
4.3		 1hrkB-3s2uA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 LEU A 392
PRO A 271
LEU A 394
ARG A  41
 None
 1.39A 1hrkB-3sdoA:
undetectable		 1hrkB-3sdoA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 LEU A  77
PRO A  78
LEU A  22
ARG A  20
 None
 1.38A 1hrkB-3szbA:
2.8		 1hrkB-3szbA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		4 LEU B 419
PRO B 420
LEU B 423
ARG B 402
 None
 1.22A 1hrkB-3thwB:
undetectable		 1hrkB-3thwB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 200
PRO A 212
LEU A 195
ARG A 194
 None
 1.24A 1hrkB-3tqpA:
undetectable		 1hrkB-3tqpA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A1543
PRO A1654
LEU A1545
ARG A1556
 None
 1.36A 1hrkB-3vkgA:
undetectable		 1hrkB-3vkgA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		4 LEU A 194
PRO A 193
LEU A 273
ARG A 271
 None
 1.34A 1hrkB-4bgbA:
2.6		 1hrkB-4bgbA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		4 LEU A 337
PRO A 338
LEU A 340
ARG A 325
 None
 1.31A 1hrkB-4e7wA:
undetectable		 1hrkB-4e7wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frw POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 4

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 LEU A  50
PRO A  51
LEU A 141
ARG A 142
 None
 1.29A 1hrkB-4frwA:
undetectable		 1hrkB-4frwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB

(Acinetobacter
baumannii) 		PF01636
(APH) 		4 LEU A  81
PRO A  82
LEU A  72
ARG A  71
 None
0J9  A 302 (-4.5A)
None
None
 1.16A 1hrkB-4gkhA:
undetectable		 1hrkB-4gkhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hse CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF00004
(AAA) 		4 LEU A 224
PRO A 221
LEU A 187
ARG A 188
 None
 1.42A 1hrkB-4hseA:
2.3		 1hrkB-4hseA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		4 LEU A 151
PRO A 196
LEU A 197
ARG A 429
 None
 1.39A 1hrkB-4hz8A:
undetectable		 1hrkB-4hz8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8b COATOMER ALPHA
SUBUNIT

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 LEU A 224
PRO A 225
LEU A 226
ARG A 288
 None
 1.14A 1hrkB-4j8bA:
undetectable		 1hrkB-4j8bA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9w ARA H 8 ALLERGEN

(Arachis
hypogaea) 		PF00407
(Bet_v_1) 		4 LEU A 103
PRO A  16
LEU A  19
ARG A 144
 None
 1.33A 1hrkB-4m9wA:
undetectable		 1hrkB-4m9wA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nex ACETYLGLUTAMATE
KINASE

(Xylella
fastidiosa) 		PF04768
(NAT) 		4 LEU A 344
PRO A 351
LEU A 330
ARG A 295
 None
 1.45A 1hrkB-4nexA:
undetectable		 1hrkB-4nexA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf1 ACETYLGLUTAMATE
KINASE

(Xylella
fastidiosa) 		PF04768
(NAT) 		4 LEU A 344
PRO A 351
LEU A 330
ARG A 295
 None
 1.36A 1hrkB-4nf1A:
undetectable		 1hrkB-4nf1A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		4 LEU A 797
PRO A  36
LEU A 800
ARG A 804
 None
 1.17A 1hrkB-4ogcA:
undetectable		 1hrkB-4ogcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onr DECORIN-BINDING
PROTEIN DBPA

(Borreliella
burgdorferi) 		PF02352
(Decorin_bind) 		4 LEU A 126
PRO A 125
LEU A 129
ARG A  84
 None
 1.11A 1hrkB-4onrA:
undetectable		 1hrkB-4onrA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pba UNCHARACTERIZED
PROTEIN ABASI

(Acinetobacter
baumannii) 		no annotation 4 LEU B 222
PRO B 266
LEU B 214
ARG B 210
 None
 1.30A 1hrkB-4pbaB:
undetectable		 1hrkB-4pbaB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 LEU A 386
PRO A 383
LEU A 397
ARG A 399
 None
 1.44A 1hrkB-4pzvA:
2.8		 1hrkB-4pzvA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		PF12166
(Piezo_RRas_bdg) 		4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.37A 1hrkB-4raxA:
undetectable		 1hrkB-4raxA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 112
PRO A 291
LEU A 109
ARG A 107
 None
 1.40A 1hrkB-4rcnA:
2.2		 1hrkB-4rcnA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		4 LEU A 390
PRO A 391
LEU A 393
ARG A 422
 None
 1.38A 1hrkB-4xguA:
2.4		 1hrkB-4xguA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.13A 1hrkB-4zasA:
2.3		 1hrkB-4zasA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		4 LEU A 198
PRO A 195
LEU A 233
ARG A 240
 None
 1.39A 1hrkB-4zm4A:
2.4		 1hrkB-4zm4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3g M50

(Murid
betaherpesvirus
1) 		PF04541
(Herpes_U34) 		4 LEU A  96
PRO A  93
LEU A  99
ARG A 101
 None
 1.41A 1hrkB-5a3gA:
undetectable		 1hrkB-5a3gA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f HUMAN SAFFOLD
VIRUS-3 VP1
HUMAN SAFFOLD
VIRUS-3 VP2

(Cardiovirus B;
Cardiovirus B) 		no annotation
PF00073
(Rhv) 		4 LEU A  73
PRO A  74
LEU C 182
ARG A 252
 None
 1.30A 1hrkB-5a8fA:
undetectable		 1hrkB-5a8fA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 292
PRO A 291
LEU A 293
ARG A 456
 None
 1.40A 1hrkB-5agaA:
4.4		 1hrkB-5agaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b01 MOEN5

(Streptomyces
viridosporus) 		no annotation 4 LEU A  59
PRO A  39
LEU A  42
ARG A 171
 None
 1.35A 1hrkB-5b01A:
undetectable		 1hrkB-5b01A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnz GLUTAMINE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 LEU A 241
PRO A 240
LEU A 187
ARG A 188
 None
 1.28A 1hrkB-5bnzA:
3.0		 1hrkB-5bnzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4

(Mus musculus) 		PF01852
(START) 		4 LEU A  93
PRO A  90
LEU A 102
ARG A 116
 None
 1.40A 1hrkB-5brlA:
undetectable		 1hrkB-5brlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnw BLR0248 PROTEIN

(Bradyrhizobium
diazoefficiens) 		no annotation 4 LEU C 237
PRO C 238
LEU C 233
ARG C  42
 None
 1.42A 1hrkB-5gnwC:
2.9		 1hrkB-5gnwC:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1) 		no annotation 4 LEU G   7
PRO G   6
LEU G  20
ARG G  21
 None
 1.06A 1hrkB-5h0rG:
undetectable		 1hrkB-5h0rG:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE

(Bacillus
anthracis) 		PF04127
(DFP) 		4 LEU A 376
PRO A 377
LEU A 379
ARG A 386
 None
 0.95A 1hrkB-5intA:
4.1		 1hrkB-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k35 ANKYRIN-REPEAT
PROTEIN B

(Legionella
pneumophila) 		PF12937
(F-box-like) 		4 LEU A  98
PRO A  97
LEU A 113
ARG A 115
 None
 1.43A 1hrkB-5k35A:
undetectable		 1hrkB-5k35A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 LEU A 270
PRO A 269
LEU A 271
ARG A 281
 None
 1.32A 1hrkB-5lfrA:
undetectable		 1hrkB-5lfrA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 LEU A1019
PRO A1018
LEU A 533
ARG A 535
 None
 1.28A 1hrkB-5lq3A:
undetectable		 1hrkB-5lq3A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		4 LEU A 349
PRO A 350
LEU A  99
ARG A 368
 7O9  A 602 (-3.5A)
None
None
None
 1.40A 1hrkB-5mjuA:
undetectable		 1hrkB-5mjuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 LEU A1399
PRO A1400
LEU A1378
ARG A1377
 None
 1.37A 1hrkB-5mzoA:
undetectable		 1hrkB-5mzoA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opg ENVELOPE
GLYCOPROTEIN GN

(Hantaan
orthohantavirus) 		PF01567
(Hanta_G1) 		4 LEU A  46
PRO A 140
LEU A 161
ARG A 165
 None
 1.26A 1hrkB-5opgA:
undetectable		 1hrkB-5opgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 LEU A 251
PRO A 252
LEU A 140
ARG A  64
 None
 1.45A 1hrkB-5t65A:
undetectable		 1hrkB-5t65A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 LEU A 251
PRO A 248
LEU A 250
ARG A 211
 None
None
None
ADP  A 602 (-3.4A)
 1.44A 1hrkB-5u3cA:
3.0		 1hrkB-5u3cA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veb CADHERIN-6

(Homo sapiens) 		PF00028
(Cadherin) 		4 LEU X 566
PRO X 567
LEU X 527
ARG X 552
 None
A2G  X2002 ( 4.9A)
None
None
 1.41A 1hrkB-5vebX:
undetectable		 1hrkB-5vebX:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		4 LEU A 415
PRO A 446
LEU A 409
ARG A 400
 None
 1.33A 1hrkB-5xgsA:
undetectable		 1hrkB-5xgsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 4 LEU A 188
PRO A 189
LEU A 229
ARG A 121
 None
None
None
FUM  A 502 (-3.9A)
 1.39A 1hrkB-5xnzA:
undetectable		 1hrkB-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 LEU A 274
PRO A 271
LEU A 303
ARG A 299
 None
 1.41A 1hrkB-5ze4A:
5.4		 1hrkB-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.37A 1hrkB-6bpzA:
undetectable		 1hrkB-6bpzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL

(endosymbiont of
Tevnia
jerichonana) 		no annotation 4 LEU A 247
PRO A 248
LEU A 250
ARG A 120
 None
 1.20A 1hrkB-6fvsA:
undetectable		 1hrkB-6fvsA:
undetectable