SIMILAR PATTERNS OF AMINO ACIDS FOR 1HRK_B_CHDB2502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 ARG A 316
LEU A 304
PRO A 123
GLY A 178
 None
 1.00A 1hrkB-1bjwA:
undetectable		 1hrkB-1bjwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d06 NITROGEN FIXATION
REGULATORY PROTEIN
FIXL

(Sinorhizobium
meliloti) 		PF00989
(PAS) 		4 MET A 202
LEU A 182
VAL A 232
GLY A 233
 None
HEM  A 501 (-4.3A)
HEM  A 501 (-4.8A)
None
 1.01A 1hrkB-1d06A:
undetectable		 1hrkB-1d06A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		4 ARG A 239
LEU A 225
VAL A 246
GLY A 244
 SO4  A 811 (-4.3A)
SO4  A 811 (-4.7A)
None
None
 1.03A 1hrkB-1dk5A:
undetectable		 1hrkB-1dk5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 LEU A 346
PRO A 368
VAL A  56
GLY A  55
 None
 1.03A 1hrkB-1gkrA:
undetectable		 1hrkB-1gkrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwc GLUTATHIONE
S-TRANSFERASE TSI-1

(Aegilops
tauschii) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ARG A  20
PRO A  85
VAL A 158
GLY A 159
 None
 1.01A 1hrkB-1gwcA:
undetectable		 1hrkB-1gwcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 104
PRO A 123
VAL A 154
GLY A 155
 None
 1.04A 1hrkB-1jedA:
2.4		 1hrkB-1jedA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 LEU A 714
PRO A 646
VAL A 663
GLY A 664
 None
 0.92A 1hrkB-1k25A:
undetectable		 1hrkB-1k25A:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		4 PRO A 238
VAL A 277
GLY A 278
TRP A 282
 None
 0.25A 1hrkB-1lbqA:
48.3		 1hrkB-1lbqA:
49.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		4 LEU A 164
PRO A 176
VAL A 173
GLY A  83
 None
 1.02A 1hrkB-1lfwA:
undetectable		 1hrkB-1lfwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa) 		PF00139
(Lectin_legB) 		4 MET A  75
LEU A 105
PRO A  42
GLY A 212
 None
None
None
TNR  A1401 ( 3.7A)
 0.96A 1hrkB-1n47A:
undetectable		 1hrkB-1n47A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A  67
PRO A 376
VAL A 152
GLY A 151
 None
 1.03A 1hrkB-1pxtA:
2.9		 1hrkB-1pxtA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 MET A 380
LEU A 190
GLY A 397
TRP A 455
 None
None
SO4  A 475 (-4.0A)
None
 0.93A 1hrkB-1svdA:
undetectable		 1hrkB-1svdA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN

(Shigella
flexneri) 		PF02578
(Cu-oxidase_4) 		5 ARG A 115
LEU A 150
PRO A  96
VAL A  15
GLY A  14
 None
 1.46A 1hrkB-1u05A:
undetectable		 1hrkB-1u05A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uap PROCOLLAGEN
C-PROTEINASE
ENHANCER PROTEIN

(Homo sapiens) 		PF01759
(NTR) 		4 LEU A 141
PRO A 102
VAL A 131
MET A 104
 None
 0.92A 1hrkB-1uapA:
undetectable		 1hrkB-1uapA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 LEU A 413
VAL A 193
GLY A 191
TRP A 192
 None
 1.02A 1hrkB-1v4gA:
undetectable		 1hrkB-1v4gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 MET A  92
ARG A  74
VAL A  85
GLY A  84
 None
GOL  A 395 ( 4.6A)
None
None
 0.97A 1hrkB-1x9jA:
2.8		 1hrkB-1x9jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb6 (S)-ACETONE-CYANOHYD
RIN LYASE

(Hevea
brasiliensis) 		PF00561
(Abhydrolase_1) 		4 ARG A 186
LEU A 183
VAL A 106
GLY A  83
 None
 1.04A 1hrkB-1yb6A:
4.3		 1hrkB-1yb6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 LEU A 174
VAL A 119
GLY A 118
TRP A 184
 None
 0.97A 1hrkB-1z6tA:
2.3		 1hrkB-1z6tA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
furiosus) 		PF01470
(Peptidase_C15) 		4 MET A 187
PRO A  18
VAL A  67
GLY A  68
 None
 1.02A 1hrkB-1z8wA:
4.8		 1hrkB-1z8wA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfj DIADENOSINETETRAPHOS
PHATASE

(Shigella
flexneri) 		PF00149
(Metallophos) 		4 LEU A  38
PRO A  27
VAL A  59
GLY A  56
 None
 0.96A 1hrkB-2dfjA:
undetectable		 1hrkB-2dfjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus) 		PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 MET B 756
PRO B 779
MET B 787
TRP B 788
 None
 0.97A 1hrkB-2fjaB:
undetectable		 1hrkB-2fjaB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 ARG A 208
LEU A 220
VAL A 151
GLY A 152
 None
 1.02A 1hrkB-2gqwA:
undetectable		 1hrkB-2gqwA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		4 LEU A  58
PRO A  68
VAL A 587
GLY A 588
 None
 1.03A 1hrkB-2grvA:
undetectable		 1hrkB-2grvA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ius DNA TRANSLOCASE FTSK

(Escherichia
coli) 		PF01580
(FtsK_SpoIIIE) 		4 LEU A 872
PRO A 932
VAL A 934
GLY A 935
 None
 1.03A 1hrkB-2iusA:
undetectable		 1hrkB-2iusA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4i SELECTION AND UPKEEP
OF INTRAEPITHELIAL
T-CELLS PROTEIN 1

(Mus musculus) 		PF07686
(V-set) 		4 ARG A  77
LEU A  75
PRO A  53
GLY A 128
 None
 0.98A 1hrkB-2n4iA:
undetectable		 1hrkB-2n4iA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 ARG A 184
LEU A 238
VAL A 254
GLY A 253
 None
 0.92A 1hrkB-2nrjA:
undetectable		 1hrkB-2nrjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 LEU A 427
VAL A 412
GLY A 411
MET A 214
 None
 0.94A 1hrkB-2nztA:
1.6		 1hrkB-2nztA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 LEU A 367
VAL A 191
GLY A 192
MET A 194
 None
 0.94A 1hrkB-2o1xA:
5.2		 1hrkB-2o1xA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU A 502
VAL A 606
GLY A 605
TRP A 602
 None
 0.99A 1hrkB-2qr7A:
undetectable		 1hrkB-2qr7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v41 PEROXIREDOXIN 6.

(Arenicola
marina) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A 157
PRO A 135
VAL A  64
GLY A  63
 None
 1.01A 1hrkB-2v41A:
undetectable		 1hrkB-2v41A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4y URIDYLATE KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 MET A  91
LEU A 226
VAL A  51
GLY A  52
 None
 1.01A 1hrkB-2v4yA:
4.1		 1hrkB-2v4yA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx4 CELLVIBRIO JAPONICUS
MANNANASE CJMAN26C

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		4 LEU A  75
PRO A 213
VAL A 150
GLY A 149
 None
 1.02A 1hrkB-2vx4A:
undetectable		 1hrkB-2vx4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 ARG A 311
LEU A 307
PRO A 243
GLY A 248
 None
 1.02A 1hrkB-2w3pA:
undetectable		 1hrkB-2w3pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A 531
LEU A 532
VAL A 482
GLY A 480
 None
 1.01A 1hrkB-2z1qA:
undetectable		 1hrkB-2z1qA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc4 PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF03793
(PASTA) 		4 LEU C 714
PRO C 646
VAL C 663
GLY C 664
 None
 0.97A 1hrkB-2zc4C:
undetectable		 1hrkB-2zc4C:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A  35
LEU A  33
PRO A 342
VAL A 328
 None
 0.96A 1hrkB-2zc8A:
3.0		 1hrkB-2zc8A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 ARG A 127
PRO A 118
VAL A  99
GLY A 219
 None
 1.02A 1hrkB-3a1iA:
undetectable		 1hrkB-3a1iA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		8 MET A  99
ARG A 114
LEU A 115
PRO A 266
VAL A 305
GLY A 306
MET A 308
TRP A 310
 CHD  A   2 (-4.0A)
CHD  A   2 (-3.6A)
CHD  A   2 ( 4.8A)
CHD  A   2 ( 4.5A)
CHD  A   1 ( 4.9A)
CHD  A   2 ( 3.8A)
None
CHD  A   2 (-4.7A)
 0.37A 1hrkB-3aqiA:
60.9		 1hrkB-3aqiA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 168
PRO A 152
VAL A  38
GLY A 157
 None
 0.98A 1hrkB-3aupA:
undetectable		 1hrkB-3aupA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		5 LEU A 283
PRO A 294
VAL A 267
GLY A 266
TRP A 295
 None
 1.47A 1hrkB-3bv4A:
undetectable		 1hrkB-3bv4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chi P-AMINOBENZOATE
N-OXYGENASE

(Streptomyces
thioluteus) 		PF11583
(AurF) 		4 ARG A 244
VAL A 116
GLY A 115
MET A 113
 None
 0.99A 1hrkB-3chiA:
undetectable		 1hrkB-3chiA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2

(Burkholderia
pseudomallei) 		PF00464
(SHMT) 		4 ARG A 366
LEU A 321
PRO A 221
GLY A 178
 None
 0.97A 1hrkB-3ecdA:
undetectable		 1hrkB-3ecdA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B 402
PRO B 487
VAL B 465
GLY B 464
 None
 1.02A 1hrkB-3h0gB:
undetectable		 1hrkB-3h0gB:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtx AMINOTRANSFERASE

(Neisseria
meningitidis) 		PF00155
(Aminotran_1_2) 		4 LEU A 236
PRO A 155
VAL A 192
TRP A 157
 None
 1.03A 1hrkB-3jtxA:
undetectable		 1hrkB-3jtxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcz O-METHYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 LEU A 280
VAL A 322
GLY A 321
TRP A 318
 None
 1.04A 1hrkB-3mczA:
undetectable		 1hrkB-3mczA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 4 MET A 281
ARG A 268
VAL A 263
GLY A 264
 None
None
FAD  A 601 (-3.7A)
FAD  A 601 (-3.2A)
 0.83A 1hrkB-3nlcA:
2.8		 1hrkB-3nlcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 MET A 351
LEU A 335
VAL A 307
GLY A 306
 None
 0.94A 1hrkB-3nowA:
undetectable		 1hrkB-3nowA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qye TBC1 DOMAIN FAMILY
MEMBER 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 MET A 777
LEU A 992
VAL A 801
GLY A 800
 None
 1.02A 1hrkB-3qyeA:
undetectable		 1hrkB-3qyeA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re1 UROPORPHYRINOGEN-III
SYNTHETASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02602
(HEM4) 		4 LEU A 117
PRO A 129
VAL A 154
GLY A 153
 None
 1.01A 1hrkB-3re1A:
4.8		 1hrkB-3re1A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK

(Escherichia
coli) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 MET A 198
ARG A 351
VAL A 371
GLY A 370
 None
 1.01A 1hrkB-3rlfA:
undetectable		 1hrkB-3rlfA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		4 MET A  34
LEU A 285
PRO A 268
GLY A 130
 None
 1.03A 1hrkB-3rpwA:
undetectable		 1hrkB-3rpwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 LEU A 174
VAL A 119
GLY A 118
TRP A 184
 None
 0.92A 1hrkB-3sfzA:
2.2		 1hrkB-3sfzA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		4 MET A 130
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 0.60A 1hrkB-3ubcA:
undetectable		 1hrkB-3ubcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 ARG A  15
LEU A  11
PRO A  79
MET A 136
 None
 0.99A 1hrkB-3ummA:
undetectable		 1hrkB-3ummA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 LEU A 122
PRO A 309
GLY A 422
TRP A 419
 None
 1.01A 1hrkB-3v1vA:
undetectable		 1hrkB-3v1vA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v64 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 ARG C 479
LEU C 481
VAL C 505
GLY C 542
 None
 0.93A 1hrkB-3v64C:
undetectable		 1hrkB-3v64C:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		4 PRO A 468
VAL A 602
GLY A 601
TRP A 469
 None
 0.85A 1hrkB-3wrfA:
undetectable		 1hrkB-3wrfA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE

(Polaromonas sp.
JS666) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 LEU A 246
PRO A  45
VAL A 155
GLY A 156
 None
 0.94A 1hrkB-4dllA:
2.4		 1hrkB-4dllA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		4 ARG A 439
LEU A 396
PRO A  72
VAL A  69
 None
 1.01A 1hrkB-4e4jA:
undetectable		 1hrkB-4e4jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzn BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		4 LEU A 207
PRO A   2
VAL A 156
GLY A 157
 None
 1.00A 1hrkB-4fznA:
undetectable		 1hrkB-4fznA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxc FEFE-HYDROGENASE
MATURASE

(Thermotoga
maritima) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 ARG A 180
LEU A 184
VAL A 225
GLY A 226
 SAM  A 402 (-3.3A)
CSO  A 183 ( 4.4A)
None
None
 0.87A 1hrkB-4jxcA:
undetectable		 1hrkB-4jxcA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 MET B 399
LEU B 305
PRO B 287
GLY B 284
 None
 1.04A 1hrkB-4l37B:
undetectable		 1hrkB-4l37B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 430
PRO A 322
GLY A 395
MET A 394
 None
 0.96A 1hrkB-4pdsA:
undetectable		 1hrkB-4pdsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		4 LEU A 280
VAL A 268
GLY A 288
MET A 290
 None
 0.95A 1hrkB-4q0mA:
4.7		 1hrkB-4q0mA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 PRO A 458
VAL A 587
GLY A 586
TRP A 459
 None
 0.79A 1hrkB-4qjyA:
undetectable		 1hrkB-4qjyA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql9 ALKYLHYDROPEROXIDE
REDUCTASE SUBUNIT C

(Escherichia
coli) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A 149
PRO A 127
VAL A  66
GLY A  65
 None
 0.95A 1hrkB-4ql9A:
undetectable		 1hrkB-4ql9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		no annotation 4 LEU B 280
VAL B 268
GLY B 288
MET B 290
 None
 0.97A 1hrkB-4ra6B:
3.1		 1hrkB-4ra6B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 4 ARG A 169
VAL A 211
GLY A 212
TRP A 229
 BGC  A 709 ( 3.9A)
None
None
None
 0.95A 1hrkB-4tz5A:
undetectable		 1hrkB-4tz5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 LEU A 202
PRO A  45
VAL A  59
GLY A  58
 None
 0.99A 1hrkB-4uzuA:
undetectable		 1hrkB-4uzuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		4 MET A 162
VAL A 144
GLY A 145
TRP A 156
 None
 0.98A 1hrkB-4wcjA:
undetectable		 1hrkB-4wcjA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3) 		4 ARG A 316
LEU A 515
GLY A 239
MET A 241
 None
 1.02A 1hrkB-4xvgA:
undetectable		 1hrkB-4xvgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ARG A 164
LEU A 160
VAL A 216
GLY A 192
 None
 0.94A 1hrkB-4xybA:
4.1		 1hrkB-4xybA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 LEU A  87
PRO A 187
VAL A 238
GLY A 235
 None
 0.98A 1hrkB-4yacA:
3.9		 1hrkB-4yacA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ARG A 381
LEU A 382
PRO A 307
GLY A 519
 None
 0.83A 1hrkB-4ynuA:
undetectable		 1hrkB-4ynuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		4 LEU A 281
PRO A 173
VAL A 208
TRP A 206
 None
 0.89A 1hrkB-4z23A:
undetectable		 1hrkB-4z23A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 4 LEU A 459
PRO A 243
VAL A 239
GLY A 238
 None
 1.04A 1hrkB-5aa6A:
undetectable		 1hrkB-5aa6A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5u L-ASPARAGINASE

(Pyrococcus
furiosus) 		no annotation 4 LEU B 280
VAL B 268
GLY B 288
MET B 290
 None
 0.83A 1hrkB-5b5uB:
undetectable		 1hrkB-5b5uB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 ARG A 163
PRO A 377
VAL A 390
GLY A 389
 None
 1.03A 1hrkB-5by3A:
undetectable		 1hrkB-5by3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		4 LEU A 365
PRO A  44
VAL A  40
GLY A  39
 None
 0.78A 1hrkB-5bz3A:
undetectable		 1hrkB-5bz3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Homo sapiens) 		PF04189
(Gcd10p) 		4 ARG B 417
LEU B 414
VAL B 399
MET B 206
 None
 0.98A 1hrkB-5ccxB:
2.4		 1hrkB-5ccxB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MINOR STRUCTURAL
PROTEIN 5

(Lactococcus
phage Tuc2009) 		no annotation 4 MET B  58
LEU B  69
VAL B 177
GLY B  54
 None
 0.81A 1hrkB-5e7tB:
undetectable		 1hrkB-5e7tB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 4 MET B 687
PRO B 695
VAL B 737
GLY B 735
 None
 0.92A 1hrkB-5efnB:
2.1		 1hrkB-5efnB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0h HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 MET A 687
PRO A 695
VAL A 737
GLY A 735
 None
 0.92A 1hrkB-5g0hA:
undetectable		 1hrkB-5g0hA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikk HISTONE DEACETYLASE
CLR3

(Schizosaccharomyces
pombe) 		PF00850
(Hist_deacetyl)
PF09757
(Arb2) 		4 MET A 309
PRO A 317
VAL A 359
GLY A 357
 None
 0.96A 1hrkB-5ikkA:
4.0		 1hrkB-5ikkA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 MET A 203
ARG A 192
LEU A 190
GLY A 136
 None
 1.01A 1hrkB-5iojA:
undetectable		 1hrkB-5iojA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 4 LEU B  97
VAL B 227
GLY B 226
MET B 180
 None
 0.92A 1hrkB-5lhsB:
undetectable		 1hrkB-5lhsB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		4 MET A 197
LEU A 184
VAL A 150
GLY A 151
 None
 1.00A 1hrkB-5lq4A:
undetectable		 1hrkB-5lq4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxg ADIPONECTIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF03006
(HlyIII) 		4 LEU A 365
VAL A 297
GLY A 298
MET A 300
 None
 0.77A 1hrkB-5lxgA:
undetectable		 1hrkB-5lxgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 4 ARG A  35
LEU A  32
VAL A  18
GLY A  17
 None
 1.03A 1hrkB-5mpmA:
2.6		 1hrkB-5mpmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		4 ARG A1082
LEU A1047
VAL A1075
GLY A1076
 None
 0.84A 1hrkB-5n8oA:
2.6		 1hrkB-5n8oA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 MET A 388
LEU A 199
GLY A 405
TRP A 463
 None
None
CAP  A1001 (-3.7A)
None
 1.01A 1hrkB-5nv3A:
undetectable		 1hrkB-5nv3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot0 L-ASPARAGINASE

(Thermococcus
kodakarensis) 		no annotation 4 LEU A 281
VAL A 269
GLY A 289
MET A 291
 None
 0.87A 1hrkB-5ot0A:
3.4		 1hrkB-5ot0A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 LEU A1192
PRO A1141
VAL A1073
GLY A1072
 None
 0.97A 1hrkB-5vadA:
2.4		 1hrkB-5vadA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 4 MET A 555
LEU A 368
VAL A 571
GLY A 570
 None
None
None
C2F  A3001 (-3.5A)
 0.86A 1hrkB-5vopA:
undetectable		 1hrkB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 4 LEU A 510
PRO A 459
VAL A 391
GLY A 390
 None
 0.85A 1hrkB-5xiiA:
3.6		 1hrkB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6coy CHLORIDE CHANNEL
PROTEIN 1

(Homo sapiens) 		no annotation 4 PRO A 420
VAL A 229
GLY A 230
MET A 485
 None
None
CL  A1001 (-3.2A)
None
 0.92A 1hrkB-6coyA:
undetectable		 1hrkB-6coyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ct0 DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ARG 0 471
LEU 0 468
VAL 0 534
GLY 0 533
 None
 0.93A 1hrkB-6ct00:
undetectable		 1hrkB-6ct00:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 MET A1083
ARG A1107
LEU A1149
GLY A1072
 None
 0.93A 1hrkB-6emkA:
undetectable		 1hrkB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyy ACRIIA6

(Streptococcus
phage 73) 		no annotation 4 ARG A 111
LEU A 107
VAL A 136
GLY A 116
 None
 1.01A 1hrkB-6eyyA:
undetectable		 1hrkB-6eyyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE

(Synechocystis
sp. PCC 6803;
Deinococcus
radiodurans) 		no annotation 4 ARG A 192
LEU A 195
VAL A 269
GLY A 270
 None
 0.88A 1hrkB-6fhtA:
undetectable		 1hrkB-6fhtA:
undetectable