SIMILAR PATTERNS OF AMINO ACIDS FOR 1HRK_A_CHDA1503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea)
PF01070
(FMN_dh)
3 LEU A 174
PRO A 175
LEU A 178
None
0.47A 1hrkA-1al8A:
undetectable
1hrkA-1al8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bix AP ENDONUCLEASE 1

(Homo sapiens)
PF03372
(Exo_endo_phos)
3 LEU A 104
PRO A 105
LEU A 108
None
0.54A 1hrkA-1bixA:
undetectable
1hrkA-1bixA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE


(Bacillus
circulans)
PF00266
(Aminotran_5)
3 LEU A 221
PRO A 222
LEU A 225
None
0.47A 1hrkA-1bt4A:
undetectable
1hrkA-1bt4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE


(Serratia
marcescens)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C)
3 LEU A 410
PRO A 411
LEU A 112
None
0.49A 1hrkA-1c7tA:
undetectable
1hrkA-1c7tA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chm CREATINE
AMIDINOHYDROLASE


(Pseudomonas
putida)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
3 LEU A 363
PRO A 364
LEU A 367
None
0.55A 1hrkA-1chmA:
undetectable
1hrkA-1chmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE


(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
3 LEU A 208
PRO A 162
LEU A 205
None
0.54A 1hrkA-1ddkA:
undetectable
1hrkA-1ddkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 LEU A 106
PRO A 107
LEU A 110
NAD  A 500 (-3.9A)
NAD  A 500 (-4.5A)
None
0.40A 1hrkA-1evjA:
3.8
1hrkA-1evjA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae)
PF00026
(Asp)
3 LEU A 223
PRO A 224
LEU A 227
None
0.43A 1hrkA-1g0vA:
undetectable
1hrkA-1g0vA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g13 GANGLIOSIDE M2
ACTIVATOR PROTEIN


(Homo sapiens)
PF02221
(E1_DerP2_DerF2)
3 LEU A 128
PRO A 129
LEU A 132
None
0.53A 1hrkA-1g13A:
undetectable
1hrkA-1g13A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE


(Thermotoga
maritima)
PF00128
(Alpha-amylase)
PF09083
(DUF1923)
3 LEU A 268
PRO A 269
LEU A 272
None
0.55A 1hrkA-1gjuA:
undetectable
1hrkA-1gjuA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1


(Streptomyces
coelicolor)
PF00067
(p450)
3 LEU A  37
PRO A  38
LEU A  82
None
0.50A 1hrkA-1gwiA:
undetectable
1hrkA-1gwiA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 LEU A 158
PRO A 159
LEU A 162
NDP  A 500 (-4.1A)
NDP  A 500 (-4.1A)
None
0.47A 1hrkA-1h6dA:
undetectable
1hrkA-1h6dA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE


(Sulfolobus
acidocaldarius)
PF00128
(Alpha-amylase)
PF09196
(DUF1953)
3 LEU A 713
PRO A 714
LEU A 699
None
0.47A 1hrkA-1iv8A:
undetectable
1hrkA-1iv8A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA


(Thermus
thermophilus)
PF01330
(RuvA_N)
PF14520
(HHH_5)
3 LEU A  92
PRO A  93
LEU A  96
None
0.51A 1hrkA-1ixrA:
undetectable
1hrkA-1ixrA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ku2 SIGMA FACTOR SIGA

(Thermus
aquaticus)
PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
3 LEU A 181
PRO A 182
LEU A 185
None
0.54A 1hrkA-1ku2A:
undetectable
1hrkA-1ku2A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
3 LEU A 137
PRO A 138
LEU A 143
None
0.48A 1hrkA-1kvkA:
undetectable
1hrkA-1kvkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana)
PF00161
(RIP)
3 LEU A 226
PRO A 227
LEU A 230
None
None
MLY  A 231 ( 4.0A)
0.46A 1hrkA-1llnA:
undetectable
1hrkA-1llnA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ


(Escherichia
coli)
PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C)
3 LEU A 332
PRO A 333
LEU A 336
None
0.51A 1hrkA-1ni5A:
2.6
1hrkA-1ni5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE


(Saccharomyces
cerevisiae)
PF01259
(SAICAR_synt)
3 LEU A  89
PRO A  90
LEU A  93
None
0.54A 1hrkA-1obgA:
undetectable
1hrkA-1obgA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or7 RNA POLYMERASE
SIGMA-E FACTOR


(Escherichia
coli)
PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
3 LEU A 138
PRO A 139
LEU A 142
None
0.50A 1hrkA-1or7A:
undetectable
1hrkA-1or7A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea)
PF01338
(Bac_thur_toxin)
3 LEU A  13
PRO A  14
LEU A  17
None
0.44A 1hrkA-1pp0A:
undetectable
1hrkA-1pp0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
3 LEU A 513
PRO A 438
LEU A 522
None
0.00A 1hrkA-1q5aA:
undetectable
1hrkA-1q5aA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qas PHOSPHOLIPASE C
DELTA-1


(Rattus
norvegicus)
PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like)
3 LEU A 425
PRO A 426
LEU A 302
None
0.45A 1hrkA-1qasA:
3.7
1hrkA-1qasA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND


(Mycobacterium
tuberculosis)
PF01436
(NHL)
3 LEU A  61
PRO A  62
LEU A  92
None
0.54A 1hrkA-1rwlA:
undetectable
1hrkA-1rwlA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND


(Mycobacterium
tuberculosis)
PF01436
(NHL)
3 LEU A 102
PRO A 103
LEU A 134
None
0.54A 1hrkA-1rwlA:
undetectable
1hrkA-1rwlA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1f PUTATIVE CYTOCHROME
P450


(Streptomyces
coelicolor)
PF00067
(p450)
3 LEU A  44
PRO A  45
LEU A  82
None
0.50A 1hrkA-1s1fA:
undetectable
1hrkA-1s1fA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9a CHLOROCATECHOL
1,2-DIOXYGENASE


(Rhodococcus
opacus)
PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N)
3 LEU A 141
PRO A 142
LEU A 146
None
0.48A 1hrkA-1s9aA:
undetectable
1hrkA-1s9aA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus)
PF00135
(COesterase)
3 LEU A 313
PRO A 314
LEU A 317
None
0.51A 1hrkA-1thgA:
3.6
1hrkA-1thgA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlq HYPOTHETICAL PROTEIN
YPJQ


(Bacillus
subtilis)
PF04608
(PgpA)
3 LEU A  85
PRO A  84
LEU A  88
None
0.54A 1hrkA-1tlqA:
undetectable
1hrkA-1tlqA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE


(Escherichia
coli)
PF03710
(GlnE)
PF08335
(GlnD_UR_UTase)
3 LEU A  19
PRO A  20
LEU A  23
None
0.54A 1hrkA-1v4aA:
undetectable
1hrkA-1v4aA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Thermus
thermophilus)
PF02350
(Epimerase_2)
3 LEU A 191
PRO A 192
LEU A 195
None
0.54A 1hrkA-1v4vA:
2.4
1hrkA-1v4vA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wju NEDD8 ULTIMATE
BUSTER-1


(Homo sapiens)
no annotation 3 LEU A  22
PRO A  23
LEU A  26
None
0.24A 1hrkA-1wjuA:
undetectable
1hrkA-1wjuA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlf PEROXISOME
BIOGENESIS FACTOR 1


(Mus musculus)
PF09262
(PEX-1N)
PF09263
(PEX-2N)
3 LEU A  31
PRO A  32
LEU A  35
None
0.55A 1hrkA-1wlfA:
undetectable
1hrkA-1wlfA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wm9 GTP CYCLOHYDROLASE I

(Thermus
thermophilus)
PF01227
(GTP_cyclohydroI)
3 LEU A 113
PRO A 114
LEU A 178
None
0.44A 1hrkA-1wm9A:
undetectable
1hrkA-1wm9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE


(Pyrococcus
furiosus)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 LEU A  30
PRO A  31
LEU A  34
PO4  A 495 ( 4.7A)
None
None
0.47A 1hrkA-1wp9A:
3.6
1hrkA-1wp9A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN


(Thermus
thermophilus)
PF02615
(Ldh_2)
3 LEU A 302
PRO A 303
LEU A 169
None
0.48A 1hrkA-1x0aA:
undetectable
1hrkA-1x0aA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdn RNA EDITING LIGASE
MP52


(Trypanosoma
brucei)
PF09414
(RNA_ligase)
3 LEU A 266
PRO A 265
LEU A 269
None
0.51A 1hrkA-1xdnA:
undetectable
1hrkA-1xdnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE


(Thermotoga
maritima)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
3 LEU A 693
PRO A 694
LEU A 697
None
0.52A 1hrkA-1xpgA:
undetectable
1hrkA-1xpgA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc6 COAT PROTEIN

(Brome mosaic
virus)
no annotation 3 LEU A  73
PRO A  74
LEU A  77
None
0.44A 1hrkA-1yc6A:
undetectable
1hrkA-1yc6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE


(Escherichia
coli)
PF04996
(AstB)
3 LEU A 165
PRO A 166
LEU A 171
None
0.55A 1hrkA-1yniA:
undetectable
1hrkA-1yniA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 LEU A  78
PRO A  79
LEU A  82
NAP  A 400 (-4.7A)
NAP  A 400 (-4.5A)
NAP  A 400 (-4.7A)
0.55A 1hrkA-1zh8A:
3.9
1hrkA-1zh8A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a33 HYPOTHETICAL PROTEIN

(Arabidopsis
thaliana)
PF03641
(Lysine_decarbox)
3 LEU A 116
PRO A 117
LEU A  57
None
0.52A 1hrkA-2a33A:
2.6
1hrkA-2a33A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5i CYTOKINE RECEPTOR
COMMON GAMMA CHAIN


(Homo sapiens)
PF00041
(fn3)
PF09240
(IL6Ra-bind)
3 LEU C  35
PRO C  36
LEU C 110
None
0.52A 1hrkA-2b5iC:
undetectable
1hrkA-2b5iC:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE


(Mycobacterium
tuberculosis)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
3 LEU A 100
PRO A 101
LEU A 104
None
0.44A 1hrkA-2c2yA:
4.1
1hrkA-2c2yA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czv RIBONUCLEASE P
PROTEIN COMPONENT 2


(Pyrococcus
horikoshii)
PF01900
(RNase_P_Rpp14)
3 LEU C   8
PRO C   9
LEU C  12
None
0.53A 1hrkA-2czvC:
undetectable
1hrkA-2czvC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT


(Klebsiella
oxytoca)
PF08841
(DDR)
3 LEU A 508
PRO A 509
LEU A 512
None
0.40A 1hrkA-2d0oA:
2.9
1hrkA-2d0oA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix)
no annotation 3 LEU B 302
PRO B 303
LEU B 306
None
0.46A 1hrkA-2d4aB:
3.7
1hrkA-2d4aB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor)
PF00067
(p450)
3 LEU A  47
PRO A  48
LEU A  85
None
0.38A 1hrkA-2dkkA:
undetectable
1hrkA-2dkkA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus)
PF02645
(DegV)
3 LEU A  13
PRO A  14
LEU A  17
None
0.50A 1hrkA-2dt8A:
1.7
1hrkA-2dt8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF1


(Homo sapiens)
no annotation 3 LEU A  98
PRO A  99
LEU A 102
None
SO4  A1003 (-4.3A)
None
0.53A 1hrkA-2e9xA:
undetectable
1hrkA-2e9xA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erj CYTOKINE RECEPTOR
COMMON GAMMA CHAIN


(Homo sapiens)
PF00041
(fn3)
PF09240
(IL6Ra-bind)
3 LEU C  35
PRO C  36
LEU C 110
None
0.47A 1hrkA-2erjC:
undetectable
1hrkA-2erjC:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es4 LIPASE CHAPERONE

(Burkholderia
glumae)
PF03280
(Lipase_chap)
3 LEU D  59
PRO D  60
LEU D  63
None
0.53A 1hrkA-2es4D:
undetectable
1hrkA-2es4D:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g18 PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE


(Anabaena sp.)
PF05996
(Fe_bilin_red)
3 LEU A  39
PRO A  40
LEU A  43
None
0.37A 1hrkA-2g18A:
undetectable
1hrkA-2g18A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT


(Homo sapiens)
PF00076
(RRM_1)
3 LEU A 266
PRO A 267
LEU A 270
None
0.54A 1hrkA-2g4bA:
undetectable
1hrkA-2g4bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
3 LEU A1003
PRO A1004
LEU A1007
None
0.50A 1hrkA-2gv9A:
undetectable
1hrkA-2gv9A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h31 MULTIFUNCTIONAL
PROTEIN ADE2


(Homo sapiens)
PF00731
(AIRC)
PF01259
(SAICAR_synt)
3 LEU A 368
PRO A 369
LEU A 372
None
0.42A 1hrkA-2h31A:
4.1
1hrkA-2h31A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdo PHOSPHOGLYCOLATE
PHOSPHATASE


(Lactobacillus
plantarum)
PF13419
(HAD_2)
3 LEU A 141
PRO A 140
LEU A 144
None
0.55A 1hrkA-2hdoA:
3.3
1hrkA-2hdoA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jm4 RELAXIN RECEPTOR 1

(Homo sapiens)
PF00057
(Ldl_recept_a)
3 LEU A  21
PRO A  22
LEU A  25
None
0.54A 1hrkA-2jm4A:
undetectable
1hrkA-2jm4A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwx ZUOTIN

(Saccharomyces
cerevisiae)
PF16717
(RAC_head)
3 LEU A 424
PRO A 425
LEU A 428
None
0.44A 1hrkA-2lwxA:
undetectable
1hrkA-2lwxA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np5 TRANSCRIPTIONAL
REGULATOR


(Rhodococcus
jostii)
PF00440
(TetR_N)
PF13977
(TetR_C_6)
3 LEU A  93
PRO A  94
LEU A 176
None
0.55A 1hrkA-2np5A:
undetectable
1hrkA-2np5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME


(Agrobacterium
fabrum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 LEU A 160
PRO A 161
LEU A 171
None
0.53A 1hrkA-2nqlA:
undetectable
1hrkA-2nqlA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans)
PF01933
(UPF0052)
3 LEU A 123
PRO A 124
LEU A 168
None
0.54A 1hrkA-2o2zA:
3.1
1hrkA-2o2zA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114


(Pseudomonas
syringae group
genomosp. 3)
no annotation 3 LEU A  61
PRO A  62
LEU A  65
None
0.54A 1hrkA-2odaA:
2.7
1hrkA-2odaA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Roseovarius
nubinhibens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 LEU A 215
PRO A 216
LEU A 219
None
0.55A 1hrkA-2pceA:
3.4
1hrkA-2pceA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Aspergillus
oryzae)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 LEU A 213
PRO A 214
LEU A 217
None
0.46A 1hrkA-2ps2A:
3.7
1hrkA-2ps2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron)
PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt)
3 LEU A 681
PRO A 682
LEU A 685
None
0.53A 1hrkA-2q1fA:
undetectable
1hrkA-2q1fA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3v MEVALONATE KINASE

(Homo sapiens)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
3 LEU A 137
PRO A 138
LEU A 143
None
0.48A 1hrkA-2r3vA:
undetectable
1hrkA-2r3vA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00392
(GntR)
PF07702
(UTRA)
3 LEU A 152
PRO A 153
LEU A 156
None
0.41A 1hrkA-2ra5A:
undetectable
1hrkA-2ra5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rax BOREALIN

(Homo sapiens)
PF10444
(Nbl1_Borealin_N)
3 LEU B  61
PRO B  62
LEU B  65
None
0.49A 1hrkA-2raxB:
undetectable
1hrkA-2raxB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Homo sapiens)
PF00586
(AIRS)
PF02769
(AIRS_C)
3 LEU A 694
PRO A 695
LEU A 698
None
0.47A 1hrkA-2v9yA:
undetectable
1hrkA-2v9yA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44


(Saccharomyces
cerevisiae)
PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1)
3 LEU D 604
PRO D 605
LEU D 608
None
0.51A 1hrkA-2vnuD:
undetectable
1hrkA-2vnuD:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE


(Thermobacillus
xylanilyticus)
PF06964
(Alpha-L-AF_C)
3 LEU A 399
PRO A 400
LEU A 421
None
0.34A 1hrkA-2vrkA:
undetectable
1hrkA-2vrkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
3 LEU A 571
PRO A 572
LEU A 575
None
0.54A 1hrkA-2vwkA:
undetectable
1hrkA-2vwkA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3


(Saccharomyces
cerevisiae)
PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1)
3 LEU J 604
PRO J 605
LEU J 608
None
0.47A 1hrkA-2wp8J:
undetectable
1hrkA-2wp8J:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN


(Streptomyces
coelicolor)
PF01497
(Peripla_BP_2)
3 LEU A 180
PRO A 179
LEU A 326
None
0.52A 1hrkA-2x4lA:
undetectable
1hrkA-2x4lA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Thermosynechococcus
elongatus)
PF00148
(Oxidored_nitro)
3 LEU A 374
PRO A 375
LEU A   9
None
0.51A 1hrkA-2xdqA:
2.6
1hrkA-2xdqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME


(Homo sapiens)
PF01401
(Peptidase_M2)
3 LEU A 397
PRO A 398
LEU A 401
None
EPE  A1634 (-3.6A)
None
0.49A 1hrkA-2xy9A:
undetectable
1hrkA-2xy9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME


(Homo sapiens)
PF01401
(Peptidase_M2)
3 LEU A 375
PRO A 376
LEU A 379
None
0.46A 1hrkA-2xydA:
undetectable
1hrkA-2xydA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Thermus
thermophilus)
PF00117
(GATase)
PF00958
(GMP_synt_C)
3 LEU A 342
PRO A 343
LEU A 346
None
0.53A 1hrkA-2ywbA:
2.5
1hrkA-2ywbA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Methanocaldococcus
jannaschii)
PF01135
(PCMT)
3 LEU A  38
PRO A  39
LEU A  42
None
0.53A 1hrkA-2yxeA:
2.2
1hrkA-2yxeA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxy HYPOTHETICAL
CONSERVED PROTEIN,
GK0453


(Geobacillus
kaustophilus)
PF08838
(DUF1811)
3 LEU A 100
PRO A 101
LEU A 104
None
0.51A 1hrkA-2yxyA:
undetectable
1hrkA-2yxyA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1p COLLAGEN ADHESIN
PROTEIN


(Enterococcus
faecalis)
PF05737
(Collagen_bind)
3 LEU A  79
PRO A  80
LEU A  83
None
0.51A 1hrkA-2z1pA:
undetectable
1hrkA-2z1pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN


(Yersinia pestis)
PF00496
(SBP_bac_5)
3 LEU A 504
PRO A 503
LEU A 270
None
0.54A 1hrkA-2z23A:
undetectable
1hrkA-2z23A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE


(Pyrococcus
horikoshii)
PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD)
3 LEU A 722
PRO A 723
LEU A 727
None
0.47A 1hrkA-2zzgA:
undetectable
1hrkA-2zzgA:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens)
PF00762
(Ferrochelatase)
3 LEU A 101
PRO A 102
LEU A 107
CHD  A   3 ( 4.9A)
CHD  A   3 ( 4.7A)
CHD  A   3 ( 4.6A)
0.38A 1hrkA-3aqiA:
61.1
1hrkA-3aqiA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia)
PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69)
3 LEU A 142
PRO A 143
LEU A 150
None
0.45A 1hrkA-3bb7A:
undetectable
1hrkA-3bb7A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bba INTERPAIN A

(Prevotella
intermedia)
PF01640
(Peptidase_C10)
3 LEU A 142
PRO A 143
LEU A 150
None
0.40A 1hrkA-3bbaA:
undetectable
1hrkA-3bbaA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxj RAS
GTPASE-ACTIVATING
PROTEIN SYNGAP


(Rattus
norvegicus)
PF00168
(C2)
PF00616
(RasGAP)
3 LEU A 699
PRO A 698
LEU A 702
None
0.51A 1hrkA-3bxjA:
undetectable
1hrkA-3bxjA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
3 LEU A 449
PRO A 450
LEU A 453
None
0.50A 1hrkA-3ce6A:
4.7
1hrkA-3ce6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctd PUTATIVE ATPASE, AAA
FAMILY


(Prochlorococcus
marinus)
PF12002
(MgsA_C)
PF16193
(AAA_assoc_2)
3 LEU A 398
PRO A 399
LEU A 402
None
0.41A 1hrkA-3ctdA:
undetectable
1hrkA-3ctdA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum)
PF00067
(p450)
3 LEU A 214
PRO A 215
LEU A 218
None
0.45A 1hrkA-3danA:
undetectable
1hrkA-3danA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21


(Actinoplanes
teichomyceticus)
PF02585
(PIG-L)
3 LEU A 197
PRO A 198
LEU A 201
None
0.45A 1hrkA-3dfiA:
3.8
1hrkA-3dfiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euc HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE 2


(Cupriavidus
pinatubonensis)
PF00155
(Aminotran_1_2)
3 LEU A  43
PRO A  44
LEU A  47
None
0.48A 1hrkA-3eucA:
undetectable
1hrkA-3eucA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2


(Schizosaccharomyces
pombe)
PF03159
(XRN_N)
3 LEU A 684
PRO A 685
LEU A 688
None
0.53A 1hrkA-3fqdA:
undetectable
1hrkA-3fqdA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
3 LEU A 391
PRO A 392
LEU A 395
None
0.55A 1hrkA-3g1uA:
4.3
1hrkA-3g1uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM


(Serratia
plymuthica)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
3 LEU A 533
PRO A 534
LEU A 537
None
0.39A 1hrkA-3gbdA:
undetectable
1hrkA-3gbdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ


(Bacillus
subtilis)
PF01497
(Peripla_BP_2)
3 LEU A  65
PRO A  66
LEU A  69
None
0.54A 1hrkA-3gfvA:
2.7
1hrkA-3gfvA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE


(Trypanosoma
brucei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
3 LEU A 391
PRO A 392
LEU A 395
None
0.54A 1hrkA-3h9uA:
4.5
1hrkA-3h9uA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr6 PUTATIVE
SURFACE-ANCHORED
FIMBRIAL SUBUNIT


(Corynebacterium
diphtheriae)
no annotation 3 LEU A 243
PRO A 244
LEU A 247
None
0.54A 1hrkA-3hr6A:
undetectable
1hrkA-3hr6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyi PROTEIN DUF199/WHIA

(Thermotoga
maritima)
PF02650
(HTH_WhiA)
PF10298
(WhiA_N)
PF14527
(LAGLIDADG_WhiA)
3 LEU A 244
PRO A 245
LEU A 248
None
0.55A 1hrkA-3hyiA:
undetectable
1hrkA-3hyiA:
21.56