SIMILAR PATTERNS OF AMINO ACIDS FOR 1HRK_A_CHDA1503
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1al8 | GLYCOLATE OXIDASE (Spinaciaoleracea) |
PF01070(FMN_dh) | 3 | LEU A 174PRO A 175LEU A 178 | None | 0.47A | 1hrkA-1al8A:undetectable | 1hrkA-1al8A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bix | AP ENDONUCLEASE 1 (Homo sapiens) |
PF03372(Exo_endo_phos) | 3 | LEU A 104PRO A 105LEU A 108 | None | 0.54A | 1hrkA-1bixA:undetectable | 1hrkA-1bixA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bt4 | PHOSPHOSERINEAMINOTRANSFERASE (Bacilluscirculans) |
PF00266(Aminotran_5) | 3 | LEU A 221PRO A 222LEU A 225 | None | 0.47A | 1hrkA-1bt4A:undetectable | 1hrkA-1bt4A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c7t | BETA-N-ACETYLHEXOSAMINIDASE (Serratiamarcescens) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b)PF03173(CHB_HEX)PF03174(CHB_HEX_C) | 3 | LEU A 410PRO A 411LEU A 112 | None | 0.49A | 1hrkA-1c7tA:undetectable | 1hrkA-1c7tA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1chm | CREATINEAMIDINOHYDROLASE (Pseudomonasputida) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 3 | LEU A 363PRO A 364LEU A 367 | None | 0.55A | 1hrkA-1chmA:undetectable | 1hrkA-1chmA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ddk | IMP-1 METALLOBETA-LACTAMASE (Pseudomonasaeruginosa) |
PF00753(Lactamase_B) | 3 | LEU A 208PRO A 162LEU A 205 | None | 0.54A | 1hrkA-1ddkA:undetectable | 1hrkA-1ddkA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evj | GLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | LEU A 106PRO A 107LEU A 110 | NAD A 500 (-3.9A)NAD A 500 (-4.5A)None | 0.40A | 1hrkA-1evjA:3.8 | 1hrkA-1evjA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g0v | PROTEINASE A (Saccharomycescerevisiae) |
PF00026(Asp) | 3 | LEU A 223PRO A 224LEU A 227 | None | 0.43A | 1hrkA-1g0vA:undetectable | 1hrkA-1g0vA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g13 | GANGLIOSIDE M2ACTIVATOR PROTEIN (Homo sapiens) |
PF02221(E1_DerP2_DerF2) | 3 | LEU A 128PRO A 129LEU A 132 | None | 0.53A | 1hrkA-1g13A:undetectable | 1hrkA-1g13A:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gju | MALTODEXTRINGLYCOSYLTRANSFERASE (Thermotogamaritima) |
PF00128(Alpha-amylase)PF09083(DUF1923) | 3 | LEU A 268PRO A 269LEU A 272 | None | 0.55A | 1hrkA-1gjuA:undetectable | 1hrkA-1gjuA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gwi | CYTOCHROME P450154C1 (Streptomycescoelicolor) |
PF00067(p450) | 3 | LEU A 37PRO A 38LEU A 82 | None | 0.50A | 1hrkA-1gwiA:undetectable | 1hrkA-1gwiA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h6d | PRECURSOR FORM OFGLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | LEU A 158PRO A 159LEU A 162 | NDP A 500 (-4.1A)NDP A 500 (-4.1A)None | 0.47A | 1hrkA-1h6dA:undetectable | 1hrkA-1h6dA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iv8 | MALTOOLIGOSYLTREHALOSE SYNTHASE (Sulfolobusacidocaldarius) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 3 | LEU A 713PRO A 714LEU A 699 | None | 0.47A | 1hrkA-1iv8A:undetectable | 1hrkA-1iv8A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ixr | HOLLIDAY JUNCTIONDNA HELICASE RUVA (Thermusthermophilus) |
PF01330(RuvA_N)PF14520(HHH_5) | 3 | LEU A 92PRO A 93LEU A 96 | None | 0.51A | 1hrkA-1ixrA:undetectable | 1hrkA-1ixrA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ku2 | SIGMA FACTOR SIGA (Thermusaquaticus) |
PF00140(Sigma70_r1_2)PF04539(Sigma70_r3)PF04542(Sigma70_r2) | 3 | LEU A 181PRO A 182LEU A 185 | None | 0.54A | 1hrkA-1ku2A:undetectable | 1hrkA-1ku2A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kvk | MEVALONATE KINASE (Rattusnorvegicus) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 3 | LEU A 137PRO A 138LEU A 143 | None | 0.48A | 1hrkA-1kvkA:undetectable | 1hrkA-1kvkA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lln | ANTIVIRAL PROTEIN 3 (Phytolaccaamericana) |
PF00161(RIP) | 3 | LEU A 226PRO A 227LEU A 230 | NoneNoneMLY A 231 ( 4.0A) | 0.46A | 1hrkA-1llnA:undetectable | 1hrkA-1llnA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ni5 | PUTATIVE CELL CYCLEPROTEIN MESJ (Escherichiacoli) |
PF01171(ATP_bind_3)PF09179(TilS)PF11734(TilS_C) | 3 | LEU A 332PRO A 333LEU A 336 | None | 0.51A | 1hrkA-1ni5A:2.6 | 1hrkA-1ni5A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1obg | PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDESYNTHASE (Saccharomycescerevisiae) |
PF01259(SAICAR_synt) | 3 | LEU A 89PRO A 90LEU A 93 | None | 0.54A | 1hrkA-1obgA:undetectable | 1hrkA-1obgA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1or7 | RNA POLYMERASESIGMA-E FACTOR (Escherichiacoli) |
PF04542(Sigma70_r2)PF08281(Sigma70_r4_2) | 3 | LEU A 138PRO A 139LEU A 142 | None | 0.50A | 1hrkA-1or7A:undetectable | 1hrkA-1or7A:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pp0 | VOLVATOXIN A2 (Volvariellavolvacea) |
PF01338(Bac_thur_toxin) | 3 | LEU A 13PRO A 14LEU A 17 | None | 0.44A | 1hrkA-1pp0A:undetectable | 1hrkA-1pp0A:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 3 | LEU A 513PRO A 438LEU A 522 | None | 0.00A | 1hrkA-1q5aA:undetectable | 1hrkA-1q5aA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qas | PHOSPHOLIPASE CDELTA-1 (Rattusnorvegicus) |
PF00168(C2)PF00387(PI-PLC-Y)PF00388(PI-PLC-X)PF09279(EF-hand_like) | 3 | LEU A 425PRO A 426LEU A 302 | None | 0.45A | 1hrkA-1qasA:3.7 | 1hrkA-1qasA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rwl | SERINE/THREONINE-PROTEIN KINASE PKND (Mycobacteriumtuberculosis) |
PF01436(NHL) | 3 | LEU A 61PRO A 62LEU A 92 | None | 0.54A | 1hrkA-1rwlA:undetectable | 1hrkA-1rwlA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rwl | SERINE/THREONINE-PROTEIN KINASE PKND (Mycobacteriumtuberculosis) |
PF01436(NHL) | 3 | LEU A 102PRO A 103LEU A 134 | None | 0.54A | 1hrkA-1rwlA:undetectable | 1hrkA-1rwlA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s1f | PUTATIVE CYTOCHROMEP450 (Streptomycescoelicolor) |
PF00067(p450) | 3 | LEU A 44PRO A 45LEU A 82 | None | 0.50A | 1hrkA-1s1fA:undetectable | 1hrkA-1s1fA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s9a | CHLOROCATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 3 | LEU A 141PRO A 142LEU A 146 | None | 0.48A | 1hrkA-1s9aA:undetectable | 1hrkA-1s9aA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1thg | LIPASE 2 (Galactomycescandidus) |
PF00135(COesterase) | 3 | LEU A 313PRO A 314LEU A 317 | None | 0.51A | 1hrkA-1thgA:3.6 | 1hrkA-1thgA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tlq | HYPOTHETICAL PROTEINYPJQ (Bacillussubtilis) |
PF04608(PgpA) | 3 | LEU A 85PRO A 84LEU A 88 | None | 0.54A | 1hrkA-1tlqA:undetectable | 1hrkA-1tlqA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v4a | GLUTAMATE-AMMONIA-LIGASEADENYLYLTRANSFERASE (Escherichiacoli) |
PF03710(GlnE)PF08335(GlnD_UR_UTase) | 3 | LEU A 19PRO A 20LEU A 23 | None | 0.54A | 1hrkA-1v4aA:undetectable | 1hrkA-1v4aA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v4v | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Thermusthermophilus) |
PF02350(Epimerase_2) | 3 | LEU A 191PRO A 192LEU A 195 | None | 0.54A | 1hrkA-1v4vA:2.4 | 1hrkA-1v4vA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wju | NEDD8 ULTIMATEBUSTER-1 (Homo sapiens) |
no annotation | 3 | LEU A 22PRO A 23LEU A 26 | None | 0.24A | 1hrkA-1wjuA:undetectable | 1hrkA-1wjuA:13.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wlf | PEROXISOMEBIOGENESIS FACTOR 1 (Mus musculus) |
PF09262(PEX-1N)PF09263(PEX-2N) | 3 | LEU A 31PRO A 32LEU A 35 | None | 0.55A | 1hrkA-1wlfA:undetectable | 1hrkA-1wlfA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wm9 | GTP CYCLOHYDROLASE I (Thermusthermophilus) |
PF01227(GTP_cyclohydroI) | 3 | LEU A 113PRO A 114LEU A 178 | None | 0.44A | 1hrkA-1wm9A:undetectable | 1hrkA-1wm9A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wp9 | ATP-DEPENDENT RNAHELICASE, PUTATIVE (Pyrococcusfuriosus) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | LEU A 30PRO A 31LEU A 34 | PO4 A 495 ( 4.7A)NoneNone | 0.47A | 1hrkA-1wp9A:3.6 | 1hrkA-1wp9A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x0a | MALATE/L-LACTATEDEHYDROGENASE FAMILYPROTEIN (Thermusthermophilus) |
PF02615(Ldh_2) | 3 | LEU A 302PRO A 303LEU A 169 | None | 0.48A | 1hrkA-1x0aA:undetectable | 1hrkA-1x0aA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xdn | RNA EDITING LIGASEMP52 (Trypanosomabrucei) |
PF09414(RNA_ligase) | 3 | LEU A 266PRO A 265LEU A 269 | None | 0.51A | 1hrkA-1xdnA:undetectable | 1hrkA-1xdnA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xpg | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Thermotogamaritima) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 3 | LEU A 693PRO A 694LEU A 697 | None | 0.52A | 1hrkA-1xpgA:undetectable | 1hrkA-1xpgA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yc6 | COAT PROTEIN (Brome mosaicvirus) |
no annotation | 3 | LEU A 73PRO A 74LEU A 77 | None | 0.44A | 1hrkA-1yc6A:undetectable | 1hrkA-1yc6A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yni | SUCCINYLARGININEDIHYDROLASE (Escherichiacoli) |
PF04996(AstB) | 3 | LEU A 165PRO A 166LEU A 171 | None | 0.55A | 1hrkA-1yniA:undetectable | 1hrkA-1yniA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zh8 | OXIDOREDUCTASE (Thermotogamaritima) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | LEU A 78PRO A 79LEU A 82 | NAP A 400 (-4.7A)NAP A 400 (-4.5A)NAP A 400 (-4.7A) | 0.55A | 1hrkA-1zh8A:3.9 | 1hrkA-1zh8A:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a33 | HYPOTHETICAL PROTEIN (Arabidopsisthaliana) |
PF03641(Lysine_decarbox) | 3 | LEU A 116PRO A 117LEU A 57 | None | 0.52A | 1hrkA-2a33A:2.6 | 1hrkA-2a33A:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5i | CYTOKINE RECEPTORCOMMON GAMMA CHAIN (Homo sapiens) |
PF00041(fn3)PF09240(IL6Ra-bind) | 3 | LEU C 35PRO C 36LEU C 110 | None | 0.52A | 1hrkA-2b5iC:undetectable | 1hrkA-2b5iC:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c2y | METHYLENETETRAHYDROFOLATEDEHYDROGENASE-METHENYLTETRAHYDROFOLATECYCLOHYDROLASE (Mycobacteriumtuberculosis) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 3 | LEU A 100PRO A 101LEU A 104 | None | 0.44A | 1hrkA-2c2yA:4.1 | 1hrkA-2c2yA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2czv | RIBONUCLEASE PPROTEIN COMPONENT 2 (Pyrococcushorikoshii) |
PF01900(RNase_P_Rpp14) | 3 | LEU C 8PRO C 9LEU C 12 | None | 0.53A | 1hrkA-2czvC:undetectable | 1hrkA-2czvC:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0o | DIOLDEHYDRATASE-REACTIVATING FACTOR LARGESUBUNIT (Klebsiellaoxytoca) |
PF08841(DDR) | 3 | LEU A 508PRO A 509LEU A 512 | None | 0.40A | 1hrkA-2d0oA:2.9 | 1hrkA-2d0oA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4a | MALATE DEHYDROGENASE (Aeropyrumpernix) |
no annotation | 3 | LEU B 302PRO B 303LEU B 306 | None | 0.46A | 1hrkA-2d4aB:3.7 | 1hrkA-2d4aB:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dkk | CYTOCHROME P450 (Streptomycescoelicolor) |
PF00067(p450) | 3 | LEU A 47PRO A 48LEU A 85 | None | 0.38A | 1hrkA-2dkkA:undetectable | 1hrkA-2dkkA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dt8 | DEGV FAMILY PROTEIN (Thermusthermophilus) |
PF02645(DegV) | 3 | LEU A 13PRO A 14LEU A 17 | None | 0.50A | 1hrkA-2dt8A:1.7 | 1hrkA-2dt8A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e9x | DNA REPLICATIONCOMPLEX GINS PROTEINPSF1 (Homo sapiens) |
no annotation | 3 | LEU A 98PRO A 99LEU A 102 | NoneSO4 A1003 (-4.3A)None | 0.53A | 1hrkA-2e9xA:undetectable | 1hrkA-2e9xA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2erj | CYTOKINE RECEPTORCOMMON GAMMA CHAIN (Homo sapiens) |
PF00041(fn3)PF09240(IL6Ra-bind) | 3 | LEU C 35PRO C 36LEU C 110 | None | 0.47A | 1hrkA-2erjC:undetectable | 1hrkA-2erjC:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2es4 | LIPASE CHAPERONE (Burkholderiaglumae) |
PF03280(Lipase_chap) | 3 | LEU D 59PRO D 60LEU D 63 | None | 0.53A | 1hrkA-2es4D:undetectable | 1hrkA-2es4D:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g18 | PHYCOCYANOBILIN:FERREDOXINOXIDOREDUCTASE (Anabaena sp.) |
PF05996(Fe_bilin_red) | 3 | LEU A 39PRO A 40LEU A 43 | None | 0.37A | 1hrkA-2g18A:undetectable | 1hrkA-2g18A:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g4b | SPLICING FACTOR U2AF65 KDA SUBUNIT (Homo sapiens) |
PF00076(RRM_1) | 3 | LEU A 266PRO A 267LEU A 270 | None | 0.54A | 1hrkA-2g4bA:undetectable | 1hrkA-2g4bA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gv9 | DNA POLYMERASE (Humanalphaherpesvirus1) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | LEU A1003PRO A1004LEU A1007 | None | 0.50A | 1hrkA-2gv9A:undetectable | 1hrkA-2gv9A:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h31 | MULTIFUNCTIONALPROTEIN ADE2 (Homo sapiens) |
PF00731(AIRC)PF01259(SAICAR_synt) | 3 | LEU A 368PRO A 369LEU A 372 | None | 0.42A | 1hrkA-2h31A:4.1 | 1hrkA-2h31A:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hdo | PHOSPHOGLYCOLATEPHOSPHATASE (Lactobacillusplantarum) |
PF13419(HAD_2) | 3 | LEU A 141PRO A 140LEU A 144 | None | 0.55A | 1hrkA-2hdoA:3.3 | 1hrkA-2hdoA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jm4 | RELAXIN RECEPTOR 1 (Homo sapiens) |
PF00057(Ldl_recept_a) | 3 | LEU A 21PRO A 22LEU A 25 | None | 0.54A | 1hrkA-2jm4A:undetectable | 1hrkA-2jm4A:11.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lwx | ZUOTIN (Saccharomycescerevisiae) |
PF16717(RAC_head) | 3 | LEU A 424PRO A 425LEU A 428 | None | 0.44A | 1hrkA-2lwxA:undetectable | 1hrkA-2lwxA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2np5 | TRANSCRIPTIONALREGULATOR (Rhodococcusjostii) |
PF00440(TetR_N)PF13977(TetR_C_6) | 3 | LEU A 93PRO A 94LEU A 176 | None | 0.55A | 1hrkA-2np5A:undetectable | 1hrkA-2np5A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nql | ISOMERASE/LACTONIZING ENZYME (Agrobacteriumfabrum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | LEU A 160PRO A 161LEU A 171 | None | 0.53A | 1hrkA-2nqlA:undetectable | 1hrkA-2nqlA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o2z | HYPOTHETICAL PROTEIN (Bacillushalodurans) |
PF01933(UPF0052) | 3 | LEU A 123PRO A 124LEU A 168 | None | 0.54A | 1hrkA-2o2zA:3.1 | 1hrkA-2o2zA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oda | HYPOTHETICAL PROTEINPSPTO_2114 (Pseudomonassyringae groupgenomosp. 3) |
no annotation | 3 | LEU A 61PRO A 62LEU A 65 | None | 0.54A | 1hrkA-2odaA:2.7 | 1hrkA-2odaA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pce | PUTATIVE MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Roseovariusnubinhibens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | LEU A 215PRO A 216LEU A 219 | None | 0.55A | 1hrkA-2pceA:3.4 | 1hrkA-2pceA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ps2 | PUTATIVE MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Aspergillusoryzae) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | LEU A 213PRO A 214LEU A 217 | None | 0.46A | 1hrkA-2ps2A:3.7 | 1hrkA-2ps2A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1f | CHONDROITINASE (Bacteroidesthetaiotaomicron) |
PF02278(Lyase_8)PF09092(Lyase_N)PF09093(Lyase_catalyt) | 3 | LEU A 681PRO A 682LEU A 685 | None | 0.53A | 1hrkA-2q1fA:undetectable | 1hrkA-2q1fA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3v | MEVALONATE KINASE (Homo sapiens) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 3 | LEU A 137PRO A 138LEU A 143 | None | 0.48A | 1hrkA-2r3vA:undetectable | 1hrkA-2r3vA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ra5 | PUTATIVETRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00392(GntR)PF07702(UTRA) | 3 | LEU A 152PRO A 153LEU A 156 | None | 0.41A | 1hrkA-2ra5A:undetectable | 1hrkA-2ra5A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rax | BOREALIN (Homo sapiens) |
PF10444(Nbl1_Borealin_N) | 3 | LEU B 61PRO B 62LEU B 65 | None | 0.49A | 1hrkA-2raxB:undetectable | 1hrkA-2raxB:11.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9y | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Homo sapiens) |
PF00586(AIRS)PF02769(AIRS_C) | 3 | LEU A 694PRO A 695LEU A 698 | None | 0.47A | 1hrkA-2v9yA:undetectable | 1hrkA-2v9yA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vnu | EXOSOME COMPLEXEXONUCLEASE RRP44 (Saccharomycescerevisiae) |
PF00773(RNB)PF17215(Rrp44_S1)PF17216(Rrp44_CSD1) | 3 | LEU D 604PRO D 605LEU D 608 | None | 0.51A | 1hrkA-2vnuD:undetectable | 1hrkA-2vnuD:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vrk | ALPHA-L-ARABINOFURANOSIDASE (Thermobacillusxylanilyticus) |
PF06964(Alpha-L-AF_C) | 3 | LEU A 399PRO A 400LEU A 421 | None | 0.34A | 1hrkA-2vrkA:undetectable | 1hrkA-2vrkA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vwk | DNA POLYMERASE (Thermococcusgorgonarius) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | LEU A 571PRO A 572LEU A 575 | None | 0.54A | 1hrkA-2vwkA:undetectable | 1hrkA-2vwkA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wp8 | EXOSOME COMPLEXEXONUCLEASE DIS3 (Saccharomycescerevisiae) |
PF00773(RNB)PF13638(PIN_4)PF17215(Rrp44_S1)PF17216(Rrp44_CSD1) | 3 | LEU J 604PRO J 605LEU J 608 | None | 0.47A | 1hrkA-2wp8J:undetectable | 1hrkA-2wp8J:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x4l | FERRIC-SIDEROPHORERECEPTOR PROTEIN (Streptomycescoelicolor) |
PF01497(Peripla_BP_2) | 3 | LEU A 180PRO A 179LEU A 326 | None | 0.52A | 1hrkA-2x4lA:undetectable | 1hrkA-2x4lA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xdq | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Thermosynechococcuselongatus) |
PF00148(Oxidored_nitro) | 3 | LEU A 374PRO A 375LEU A 9 | None | 0.51A | 1hrkA-2xdqA:2.6 | 1hrkA-2xdqA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xy9 | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) |
PF01401(Peptidase_M2) | 3 | LEU A 397PRO A 398LEU A 401 | NoneEPE A1634 (-3.6A)None | 0.49A | 1hrkA-2xy9A:undetectable | 1hrkA-2xy9A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xyd | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) |
PF01401(Peptidase_M2) | 3 | LEU A 375PRO A 376LEU A 379 | None | 0.46A | 1hrkA-2xydA:undetectable | 1hrkA-2xydA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywb | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] (Thermusthermophilus) |
PF00117(GATase)PF00958(GMP_synt_C) | 3 | LEU A 342PRO A 343LEU A 346 | None | 0.53A | 1hrkA-2ywbA:2.5 | 1hrkA-2ywbA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxe | PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF01135(PCMT) | 3 | LEU A 38PRO A 39LEU A 42 | None | 0.53A | 1hrkA-2yxeA:2.2 | 1hrkA-2yxeA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxy | HYPOTHETICALCONSERVED PROTEIN,GK0453 (Geobacilluskaustophilus) |
PF08838(DUF1811) | 3 | LEU A 100PRO A 101LEU A 104 | None | 0.51A | 1hrkA-2yxyA:undetectable | 1hrkA-2yxyA:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1p | COLLAGEN ADHESINPROTEIN (Enterococcusfaecalis) |
PF05737(Collagen_bind) | 3 | LEU A 79PRO A 80LEU A 83 | None | 0.51A | 1hrkA-2z1pA:undetectable | 1hrkA-2z1pA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z23 | PERIPLASMICOLIGOPEPTIDE-BINDINGPROTEIN (Yersinia pestis) |
PF00496(SBP_bac_5) | 3 | LEU A 504PRO A 503LEU A 270 | None | 0.54A | 1hrkA-2z23A:undetectable | 1hrkA-2z23A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzg | ALANYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF01411(tRNA-synt_2c)PF07973(tRNA_SAD) | 3 | LEU A 722PRO A 723LEU A 727 | None | 0.47A | 1hrkA-2zzgA:undetectable | 1hrkA-2zzgA:18.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3aqi | FERROCHELATASE (Homo sapiens) |
PF00762(Ferrochelatase) | 3 | LEU A 101PRO A 102LEU A 107 | CHD A 3 ( 4.9A)CHD A 3 ( 4.7A)CHD A 3 ( 4.6A) | 0.38A | 1hrkA-3aqiA:61.1 | 1hrkA-3aqiA:99.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bb7 | INTERPAIN A (Prevotellaintermedia) |
PF01640(Peptidase_C10)PF13734(Inhibitor_I69) | 3 | LEU A 142PRO A 143LEU A 150 | None | 0.45A | 1hrkA-3bb7A:undetectable | 1hrkA-3bb7A:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bba | INTERPAIN A (Prevotellaintermedia) |
PF01640(Peptidase_C10) | 3 | LEU A 142PRO A 143LEU A 150 | None | 0.40A | 1hrkA-3bbaA:undetectable | 1hrkA-3bbaA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxj | RASGTPASE-ACTIVATINGPROTEIN SYNGAP (Rattusnorvegicus) |
PF00168(C2)PF00616(RasGAP) | 3 | LEU A 699PRO A 698LEU A 702 | None | 0.51A | 1hrkA-3bxjA:undetectable | 1hrkA-3bxjA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 3 | LEU A 449PRO A 450LEU A 453 | None | 0.50A | 1hrkA-3ce6A:4.7 | 1hrkA-3ce6A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctd | PUTATIVE ATPASE, AAAFAMILY (Prochlorococcusmarinus) |
PF12002(MgsA_C)PF16193(AAA_assoc_2) | 3 | LEU A 398PRO A 399LEU A 402 | None | 0.41A | 1hrkA-3ctdA:undetectable | 1hrkA-3ctdA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dan | CYTOCHROME P450 74A2 (Partheniumargentatum) |
PF00067(p450) | 3 | LEU A 214PRO A 215LEU A 218 | None | 0.45A | 1hrkA-3danA:undetectable | 1hrkA-3danA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfi | PSEUDOAGLYCONEDEACETYLASE DBV21 (Actinoplanesteichomyceticus) |
PF02585(PIG-L) | 3 | LEU A 197PRO A 198LEU A 201 | None | 0.45A | 1hrkA-3dfiA:3.8 | 1hrkA-3dfiA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3euc | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE 2 (Cupriaviduspinatubonensis) |
PF00155(Aminotran_1_2) | 3 | LEU A 43PRO A 44LEU A 47 | None | 0.48A | 1hrkA-3eucA:undetectable | 1hrkA-3eucA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fqd | 5'-3'EXORIBONUCLEASE 2 (Schizosaccharomycespombe) |
PF03159(XRN_N) | 3 | LEU A 684PRO A 685LEU A 688 | None | 0.53A | 1hrkA-3fqdA:undetectable | 1hrkA-3fqdA:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 3 | LEU A 391PRO A 392LEU A 395 | None | 0.55A | 1hrkA-3g1uA:4.3 | 1hrkA-3g1uA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gbd | SUCROSE ISOMERASESMUA FROMPROTAMINOBACTERRUBRUM (Serratiaplymuthica) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 3 | LEU A 533PRO A 534LEU A 537 | None | 0.39A | 1hrkA-3gbdA:undetectable | 1hrkA-3gbdA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gfv | UNCHARACTERIZED ABCTRANSPORTERSOLUTE-BINDINGPROTEIN YCLQ (Bacillussubtilis) |
PF01497(Peripla_BP_2) | 3 | LEU A 65PRO A 66LEU A 69 | None | 0.54A | 1hrkA-3gfvA:2.7 | 1hrkA-3gfvA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 3 | LEU A 391PRO A 392LEU A 395 | None | 0.54A | 1hrkA-3h9uA:4.5 | 1hrkA-3h9uA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hr6 | PUTATIVESURFACE-ANCHOREDFIMBRIAL SUBUNIT (Corynebacteriumdiphtheriae) |
no annotation | 3 | LEU A 243PRO A 244LEU A 247 | None | 0.54A | 1hrkA-3hr6A:undetectable | 1hrkA-3hr6A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hyi | PROTEIN DUF199/WHIA (Thermotogamaritima) |
PF02650(HTH_WhiA)PF10298(WhiA_N)PF14527(LAGLIDADG_WhiA) | 3 | LEU A 244PRO A 245LEU A 248 | None | 0.55A | 1hrkA-3hyiA:undetectable | 1hrkA-3hyiA:21.56 |