SIMILAR PATTERNS OF AMINO ACIDS FOR 1HRK_A_CHDA1502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d06 NITROGEN FIXATION
REGULATORY PROTEIN
FIXL

(Sinorhizobium
meliloti) 		PF00989
(PAS) 		4 MET A 202
LEU A 182
VAL A 232
GLY A 233
 None
HEM  A 501 (-4.3A)
HEM  A 501 (-4.8A)
None
 1.00A 1hrkA-1d06A:
undetectable		 1hrkA-1d06A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 LEU A 346
PRO A 368
VAL A  56
GLY A  55
 None
 1.03A 1hrkA-1gkrA:
undetectable		 1hrkA-1gkrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 104
PRO A 123
VAL A 154
GLY A 155
 None
 1.02A 1hrkA-1jedA:
2.5		 1hrkA-1jedA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 LEU A 714
PRO A 646
VAL A 663
GLY A 664
 None
 0.94A 1hrkA-1k25A:
undetectable		 1hrkA-1k25A:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		4 PRO A 238
VAL A 277
GLY A 278
TRP A 282
 None
 0.26A 1hrkA-1lbqA:
48.4		 1hrkA-1lbqA:
49.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		4 LEU A 164
PRO A 176
VAL A 173
GLY A  83
 None
 1.04A 1hrkA-1lfwA:
2.6		 1hrkA-1lfwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa) 		PF00139
(Lectin_legB) 		4 MET A  75
LEU A 105
PRO A  42
GLY A 212
 None
None
None
TNR  A1401 ( 3.7A)
 1.02A 1hrkA-1n47A:
undetectable		 1hrkA-1n47A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A  67
PRO A 376
VAL A 152
GLY A 151
 None
 1.02A 1hrkA-1pxtA:
2.9		 1hrkA-1pxtA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 MET A 380
LEU A 190
GLY A 397
TRP A 455
 None
None
SO4  A 475 (-4.0A)
None
 0.93A 1hrkA-1svdA:
undetectable		 1hrkA-1svdA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uap PROCOLLAGEN
C-PROTEINASE
ENHANCER PROTEIN

(Homo sapiens) 		PF01759
(NTR) 		4 LEU A 141
PRO A 102
VAL A 131
MET A 104
 None
 0.92A 1hrkA-1uapA:
undetectable		 1hrkA-1uapA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 LEU A 413
VAL A 193
GLY A 191
TRP A 192
 None
 1.03A 1hrkA-1v4gA:
undetectable		 1hrkA-1v4gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 MET A  92
ARG A  74
VAL A  85
GLY A  84
 None
GOL  A 395 ( 4.6A)
None
None
 0.98A 1hrkA-1x9jA:
2.8		 1hrkA-1x9jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb6 (S)-ACETONE-CYANOHYD
RIN LYASE

(Hevea
brasiliensis) 		PF00561
(Abhydrolase_1) 		4 ARG A 186
LEU A 183
VAL A 106
GLY A  83
 None
 1.03A 1hrkA-1yb6A:
4.2		 1hrkA-1yb6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		4 ARG A 233
VAL A 404
GLY A 403
TRP A 399
 None
 1.01A 1hrkA-1yfoA:
undetectable		 1hrkA-1yfoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 LEU A 174
VAL A 119
GLY A 118
TRP A 184
 None
 0.97A 1hrkA-1z6tA:
2.3		 1hrkA-1z6tA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfj DIADENOSINETETRAPHOS
PHATASE

(Shigella
flexneri) 		PF00149
(Metallophos) 		4 LEU A  38
PRO A  27
VAL A  59
GLY A  56
 None
 0.96A 1hrkA-2dfjA:
undetectable		 1hrkA-2dfjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		4 MET A  69
LEU A  99
PRO A 155
GLY A 162
 None
 1.02A 1hrkA-2ej0A:
undetectable		 1hrkA-2ej0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus) 		PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 MET B 756
PRO B 779
MET B 787
TRP B 788
 None
 1.01A 1hrkA-2fjaB:
undetectable		 1hrkA-2fjaB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		4 LEU A  58
PRO A  68
VAL A 587
GLY A 588
 None
 1.02A 1hrkA-2grvA:
undetectable		 1hrkA-2grvA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 ARG A 184
LEU A 238
VAL A 254
GLY A 253
 None
 0.92A 1hrkA-2nrjA:
undetectable		 1hrkA-2nrjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 LEU A 427
VAL A 412
GLY A 411
MET A 214
 None
 0.95A 1hrkA-2nztA:
2.4		 1hrkA-2nztA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 LEU A 367
VAL A 191
GLY A 192
MET A 194
 None
 0.96A 1hrkA-2o1xA:
4.4		 1hrkA-2o1xA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans) 		PF01380
(SIS) 		4 ARG A 372
LEU A 382
VAL A 473
GLY A 474
 UD1  A5002 (-3.9A)
None
None
UD1  A5002 (-3.2A)
 1.05A 1hrkA-2putA:
1.8		 1hrkA-2putA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 MET A 232
LEU A 247
PRO A  43
GLY A 376
 None
 1.02A 1hrkA-2qo3A:
3.3		 1hrkA-2qo3A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU A 502
VAL A 606
GLY A 605
TRP A 602
 None
 1.00A 1hrkA-2qr7A:
undetectable		 1hrkA-2qr7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 ARG A 470
LEU A 454
GLY A 474
MET A 475
 None
 1.05A 1hrkA-2r4jA:
2.6		 1hrkA-2r4jA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v41 PEROXIREDOXIN 6.

(Arenicola
marina) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A 157
PRO A 135
VAL A  64
GLY A  63
 None
 0.99A 1hrkA-2v41A:
undetectable		 1hrkA-2v41A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4y URIDYLATE KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 MET A  91
LEU A 226
VAL A  51
GLY A  52
 None
 1.05A 1hrkA-2v4yA:
3.7		 1hrkA-2v4yA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx4 CELLVIBRIO JAPONICUS
MANNANASE CJMAN26C

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		4 LEU A  75
PRO A 213
VAL A 150
GLY A 149
 None
 1.04A 1hrkA-2vx4A:
2.2		 1hrkA-2vx4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 ARG A 311
LEU A 307
PRO A 243
GLY A 248
 None
 0.91A 1hrkA-2w3pA:
undetectable		 1hrkA-2w3pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc4 PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF03793
(PASTA) 		4 LEU C 714
PRO C 646
VAL C 663
GLY C 664
 None
 0.99A 1hrkA-2zc4C:
undetectable		 1hrkA-2zc4C:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1

(Homo sapiens) 		PF01380
(SIS) 		4 ARG A 342
LEU A 352
VAL A 443
GLY A 444
 None
 1.05A 1hrkA-2zj4A:
3.7		 1hrkA-2zj4A:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		8 MET A  99
ARG A 114
LEU A 115
PRO A 266
VAL A 305
GLY A 306
MET A 308
TRP A 310
 CHD  A   2 (-4.0A)
CHD  A   2 (-3.6A)
CHD  A   2 ( 4.8A)
CHD  A   2 ( 4.5A)
CHD  A   1 ( 4.9A)
CHD  A   2 ( 3.8A)
None
CHD  A   2 (-4.7A)
 0.34A 1hrkA-3aqiA:
61.1		 1hrkA-3aqiA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 168
PRO A 152
VAL A  38
GLY A 157
 None
 0.97A 1hrkA-3aupA:
undetectable		 1hrkA-3aupA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		5 LEU A 283
PRO A 294
VAL A 267
GLY A 266
TRP A 295
 None
 1.48A 1hrkA-3bv4A:
undetectable		 1hrkA-3bv4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chi P-AMINOBENZOATE
N-OXYGENASE

(Streptomyces
thioluteus) 		PF11583
(AurF) 		4 ARG A 244
VAL A 116
GLY A 115
MET A 113
 None
 0.99A 1hrkA-3chiA:
undetectable		 1hrkA-3chiA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2

(Burkholderia
pseudomallei) 		PF00464
(SHMT) 		4 ARG A 366
LEU A 321
PRO A 221
GLY A 178
 None
 0.87A 1hrkA-3ecdA:
2.6		 1hrkA-3ecdA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B 402
PRO B 487
VAL B 465
GLY B 464
 None
 1.05A 1hrkA-3h0gB:
undetectable		 1hrkA-3h0gB:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		4 MET A 123
LEU A 183
VAL A  87
GLY A  86
 None
 1.05A 1hrkA-3majA:
undetectable		 1hrkA-3majA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcz O-METHYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 LEU A 280
VAL A 322
GLY A 321
TRP A 318
 None
 1.05A 1hrkA-3mczA:
undetectable		 1hrkA-3mczA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 4 MET A 281
ARG A 268
VAL A 263
GLY A 264
 None
None
FAD  A 601 (-3.7A)
FAD  A 601 (-3.2A)
 0.91A 1hrkA-3nlcA:
undetectable		 1hrkA-3nlcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 MET A 351
LEU A 335
VAL A 307
GLY A 306
 None
 0.89A 1hrkA-3nowA:
undetectable		 1hrkA-3nowA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qye TBC1 DOMAIN FAMILY
MEMBER 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 MET A 777
LEU A 992
VAL A 801
GLY A 800
 None
 1.01A 1hrkA-3qyeA:
undetectable		 1hrkA-3qyeA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re1 UROPORPHYRINOGEN-III
SYNTHETASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02602
(HEM4) 		4 LEU A 117
PRO A 129
VAL A 154
GLY A 153
 None
 0.99A 1hrkA-3re1A:
4.8		 1hrkA-3re1A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 LEU A 174
VAL A 119
GLY A 118
TRP A 184
 None
 0.92A 1hrkA-3sfzA:
2.1		 1hrkA-3sfzA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		4 MET A 130
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 0.63A 1hrkA-3ubcA:
undetectable		 1hrkA-3ubcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		4 MET A 306
PRO A 707
VAL A 692
GLY A 693
 None
 0.99A 1hrkA-3ujzA:
undetectable		 1hrkA-3ujzA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 LEU A 122
PRO A 309
GLY A 422
TRP A 419
 None
 0.97A 1hrkA-3v1vA:
undetectable		 1hrkA-3v1vA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v64 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 ARG C 479
LEU C 481
VAL C 505
GLY C 542
 None
 0.93A 1hrkA-3v64C:
undetectable		 1hrkA-3v64C:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		4 PRO A 468
VAL A 602
GLY A 601
TRP A 469
 None
 0.84A 1hrkA-3wrfA:
undetectable		 1hrkA-3wrfA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE

(Polaromonas sp.
JS666) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 LEU A 246
PRO A  45
VAL A 155
GLY A 156
 None
 0.95A 1hrkA-4dllA:
2.2		 1hrkA-4dllA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e14 KYNURENINE
FORMAMIDASE

(Drosophila
melanogaster) 		PF07859
(Abhydrolase_3) 		4 LEU A 125
PRO A  15
VAL A 190
GLY A 189
 None
None
None
SEB  A 157 ( 3.3A)
 1.04A 1hrkA-4e14A:
3.8		 1hrkA-4e14A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eei ADENYLOSUCCINATE
LYASE

(Francisella
tularensis) 		PF00206
(Lyase_1) 		4 ARG A  37
LEU A  34
VAL A  92
GLY A 182
 None
 1.00A 1hrkA-4eeiA:
undetectable		 1hrkA-4eeiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzn BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		4 LEU A 207
PRO A   2
VAL A 156
GLY A 157
 None
 0.99A 1hrkA-4fznA:
undetectable		 1hrkA-4fznA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN

(Chaetomium
thermophilum) 		PF00557
(Peptidase_M24) 		4 ARG A 336
PRO A 237
GLY A 244
TRP A 243
 None
 0.86A 1hrkA-4ipaA:
undetectable		 1hrkA-4ipaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxc FEFE-HYDROGENASE
MATURASE

(Thermotoga
maritima) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 ARG A 180
LEU A 184
VAL A 225
GLY A 226
 SAM  A 402 (-3.3A)
CSO  A 183 ( 4.4A)
None
None
 0.92A 1hrkA-4jxcA:
undetectable		 1hrkA-4jxcA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 MET B 399
LEU B 305
PRO B 287
GLY B 284
 None
 1.04A 1hrkA-4l37B:
undetectable		 1hrkA-4l37B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 MET A 387
LEU A 197
GLY A 404
TRP A 462
 None
None
RUB  A 501 (-3.7A)
None
 1.02A 1hrkA-4mkvA:
undetectable		 1hrkA-4mkvA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 430
PRO A 322
GLY A 395
MET A 394
 None
 0.96A 1hrkA-4pdsA:
undetectable		 1hrkA-4pdsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		4 LEU A 280
VAL A 268
GLY A 288
MET A 290
 None
 0.93A 1hrkA-4q0mA:
4.4		 1hrkA-4q0mA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 PRO A 458
VAL A 587
GLY A 586
TRP A 459
 None
 0.79A 1hrkA-4qjyA:
undetectable		 1hrkA-4qjyA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql9 ALKYLHYDROPEROXIDE
REDUCTASE SUBUNIT C

(Escherichia
coli) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A 149
PRO A 127
VAL A  66
GLY A  65
 None
 0.93A 1hrkA-4ql9A:
2.2		 1hrkA-4ql9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		no annotation 4 LEU B 280
VAL B 268
GLY B 288
MET B 290
 None
 0.97A 1hrkA-4ra6B:
3.1		 1hrkA-4ra6B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 4 ARG A 169
VAL A 211
GLY A 212
TRP A 229
 BGC  A 709 ( 3.9A)
None
None
None
 0.97A 1hrkA-4tz5A:
undetectable		 1hrkA-4tz5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 LEU A 202
PRO A  45
VAL A  59
GLY A  58
 None
 1.00A 1hrkA-4uzuA:
undetectable		 1hrkA-4uzuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		4 MET A 162
VAL A 144
GLY A 145
TRP A 156
 None
 0.98A 1hrkA-4wcjA:
undetectable		 1hrkA-4wcjA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ARG A 164
LEU A 160
VAL A 216
GLY A 192
 None
 0.91A 1hrkA-4xybA:
4.5		 1hrkA-4xybA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 LEU A  87
PRO A 187
VAL A 238
GLY A 235
 None
 0.98A 1hrkA-4yacA:
3.9		 1hrkA-4yacA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ARG A 381
LEU A 382
PRO A 307
GLY A 519
 None
 0.83A 1hrkA-4ynuA:
undetectable		 1hrkA-4ynuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		4 LEU A 281
PRO A 173
VAL A 208
TRP A 206
 None
 0.92A 1hrkA-4z23A:
undetectable		 1hrkA-4z23A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5u L-ASPARAGINASE

(Pyrococcus
furiosus) 		no annotation 4 LEU B 280
VAL B 268
GLY B 288
MET B 290
 None
 0.81A 1hrkA-5b5uB:
undetectable		 1hrkA-5b5uB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		4 LEU A 365
PRO A  44
VAL A  40
GLY A  39
 None
 0.77A 1hrkA-5bz3A:
undetectable		 1hrkA-5bz3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Homo sapiens) 		PF04189
(Gcd10p) 		4 ARG B 417
LEU B 414
VAL B 399
MET B 206
 None
 0.94A 1hrkA-5ccxB:
2.4		 1hrkA-5ccxB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MINOR STRUCTURAL
PROTEIN 5

(Lactococcus
phage Tuc2009) 		no annotation 4 MET B  58
LEU B  69
VAL B 177
GLY B  54
 None
 0.81A 1hrkA-5e7tB:
undetectable		 1hrkA-5e7tB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 4 MET B 687
PRO B 695
VAL B 737
GLY B 735
 None
 0.95A 1hrkA-5efnB:
2.1		 1hrkA-5efnB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0h HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 MET A 687
PRO A 695
VAL A 737
GLY A 735
 None
 0.96A 1hrkA-5g0hA:
undetectable		 1hrkA-5g0hA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 MET A 203
ARG A 192
LEU A 190
GLY A 136
 None
 1.01A 1hrkA-5hrmA:
undetectable		 1hrkA-5hrmA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikk HISTONE DEACETYLASE
CLR3

(Schizosaccharomyces
pombe) 		PF00850
(Hist_deacetyl)
PF09757
(Arb2) 		4 MET A 309
PRO A 317
VAL A 359
GLY A 357
 None
 0.98A 1hrkA-5ikkA:
4.1		 1hrkA-5ikkA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 LEU A 467
PRO A 506
VAL A 426
GLY A 425
 None
 1.03A 1hrkA-5im3A:
undetectable		 1hrkA-5im3A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 MET A 203
ARG A 192
LEU A 190
GLY A 136
 None
 0.98A 1hrkA-5iojA:
undetectable		 1hrkA-5iojA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyj SPERM-EGG FUSION
PROTEIN JUNO

(Mus musculus) 		PF03024
(Folate_rec) 		5 MET A  28
PRO A 105
VAL A 123
GLY A 122
TRP A 106
 None
 1.36A 1hrkA-5jyjA:
undetectable		 1hrkA-5jyjA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 4 LEU B  97
VAL B 227
GLY B 226
MET B 180
 None
 0.93A 1hrkA-5lhsB:
undetectable		 1hrkA-5lhsB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		4 MET A 197
LEU A 184
VAL A 150
GLY A 151
 None
 0.98A 1hrkA-5lq4A:
undetectable		 1hrkA-5lq4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxg ADIPONECTIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF03006
(HlyIII) 		4 LEU A 365
VAL A 297
GLY A 298
MET A 300
 None
 0.77A 1hrkA-5lxgA:
undetectable		 1hrkA-5lxgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		4 ARG A1082
LEU A1047
VAL A1075
GLY A1076
 None
 0.86A 1hrkA-5n8oA:
2.4		 1hrkA-5n8oA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		4 ARG A1248
LEU A1254
PRO A1385
VAL A1367
 None
 1.04A 1hrkA-5n8oA:
2.4		 1hrkA-5n8oA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 MET A 388
LEU A 199
GLY A 405
TRP A 463
 None
None
CAP  A1001 (-3.7A)
None
 1.01A 1hrkA-5nv3A:
undetectable		 1hrkA-5nv3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot0 L-ASPARAGINASE

(Thermococcus
kodakarensis) 		no annotation 4 LEU A 281
VAL A 269
GLY A 289
MET A 291
 None
 0.86A 1hrkA-5ot0A:
3.6		 1hrkA-5ot0A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta9 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF04616
(Glyco_hydro_43) 		4 ARG A 383
LEU A  76
PRO A 166
VAL A 103
 None
 1.01A 1hrkA-5ta9A:
undetectable		 1hrkA-5ta9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 LEU A1192
PRO A1141
VAL A1073
GLY A1072
 None
 0.95A 1hrkA-5vadA:
2.7		 1hrkA-5vadA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve2 ENOYL-COA HYDRATASE

(Pseudoalteromonas
atlantica) 		PF00378
(ECH_1) 		4 ARG A 161
LEU A 163
VAL A 148
GLY A 149
 ARG  A 161 ( 0.6A)
LEU  A 163 ( 0.5A)
VAL  A 148 ( 0.6A)
GLY  A 149 ( 0.0A)
 1.02A 1hrkA-5ve2A:
undetectable		 1hrkA-5ve2A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 4 MET A 555
LEU A 368
VAL A 571
GLY A 570
 None
None
None
C2F  A3001 (-3.5A)
 0.85A 1hrkA-5vopA:
undetectable		 1hrkA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 4 LEU A 510
PRO A 459
VAL A 391
GLY A 390
 None
 0.83A 1hrkA-5xiiA:
2.8		 1hrkA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 4 LEU A 430
PRO A 379
VAL A 311
GLY A 310
 None
 1.00A 1hrkA-5xipA:
2.8		 1hrkA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2v SORB

(Sorangium
cellulosum) 		no annotation 4 LEU A 261
PRO A 220
VAL A 188
GLY A 185
 None
 1.02A 1hrkA-6b2vA:
undetectable		 1hrkA-6b2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6coy CHLORIDE CHANNEL
PROTEIN 1

(Homo sapiens) 		no annotation 4 PRO A 420
VAL A 229
GLY A 230
MET A 485
 None
None
CL  A1001 (-3.2A)
None
 0.92A 1hrkA-6coyA:
undetectable		 1hrkA-6coyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ct0 DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ARG 0 471
LEU 0 468
VAL 0 534
GLY 0 533
 None
 0.85A 1hrkA-6ct00:
undetectable		 1hrkA-6ct00:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 MET A1083
ARG A1107
LEU A1149
GLY A1072
 None
 0.90A 1hrkA-6emkA:
undetectable		 1hrkA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyy ACRIIA6

(Streptococcus
phage 73) 		no annotation 4 ARG A 111
LEU A 107
VAL A 136
GLY A 116
 None
 1.03A 1hrkA-6eyyA:
undetectable		 1hrkA-6eyyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE

(Synechocystis
sp. PCC 6803;
Deinococcus
radiodurans) 		no annotation 4 ARG A 192
LEU A 195
VAL A 269
GLY A 270
 None
 0.90A 1hrkA-6fhtA:
undetectable		 1hrkA-6fhtA:
undetectable