SIMILAR PATTERNS OF AMINO ACIDS FOR 1HPK_A_ACAA80_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 PRO A 428
ASN A 317
ASP A 437
TYR A 427
 None
 1.42A 1hpkA-1aqlA:
0.0		 1hpkA-1aqlA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PRO A 372
ASP A 389
ASN A 391
TYR A 376
 None
 1.31A 1hpkA-1asoA:
0.0		 1hpkA-1asoA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 PRO A 634
ASP A 677
ASN A 679
TYR A 638
 None
 1.29A 1hpkA-1bf2A:
0.0		 1hpkA-1bf2A:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlj UDP-GLUCOSE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 PRO A 350
ASP A 383
ASN A 384
TYR A 348
 None
 1.03A 1hpkA-1dljA:
0.0		 1hpkA-1dljA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 PRO A 342
ASN A  93
ASP A  87
TYR A  75
 None
 1.12A 1hpkA-1e6vA:
0.0		 1hpkA-1e6vA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 PRO A 157
ASP A 234
ASN A 233
TYR A 210
 None
None
None
GLC  A1001 ( 4.2A)
 1.45A 1hpkA-1eljA:
0.0		 1hpkA-1eljA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fgg GLUCURONYLTRANSFERAS
E I

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 ASP A 196
ASN A 197
ASP A 194
TYR A  84
 MN  A 336 ( 1.8A)
MN  A 336 ( 4.5A)
UDP  A 337 (-3.6A)
UDP  A 337 (-3.7A)
 1.43A 1hpkA-1fggA:
0.0		 1hpkA-1fggA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jer CUCUMBER
STELLACYANIN

(Cucumis sativus) 		PF02298
(Cu_bind_like) 		4 PRO A  16
ASN A  10
ASP A   9
TYR A  22
 None
 1.35A 1hpkA-1jerA:
0.0		 1hpkA-1jerA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 ASN A 737
ASP A 736
TRP A 735
TYR A 679
 None
 1.35A 1hpkA-1uf2A:
0.0		 1hpkA-1uf2A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		4 PRO A 482
ASP A 392
ASP A 395
TYR A 400
 None
 1.46A 1hpkA-1uwiA:
undetectable		 1hpkA-1uwiA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 ASP A 197
ASN A 198
ASP A 195
TYR A  93
 MN  A 501 ( 2.0A)
MN  A 501 ( 4.6A)
UDP  A 503 (-3.5A)
UDP  A 503 (-3.7A)
 1.39A 1hpkA-1v84A:
undetectable		 1hpkA-1v84A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PRO B 240
ASP B 163
ASN B 164
ASP B 165
 None
 1.43A 1hpkA-1w85B:
undetectable		 1hpkA-1w85B:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvi PUTATIVE
PHOSPHATASES
INVOLVED IN
N-ACETYL-GLUCOSAMINE
CATABOLISM

(Streptococcus
mutans) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ASP A1206
ASN A1207
ASP A1009
TYR A1015
 None
 1.06A 1hpkA-1wviA:
undetectable		 1hpkA-1wviA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ASP A 207
ASN A 208
ASP A  10
TYR A  16
 MG  A 500 (-2.8A)
None
MG  A 500 (-2.8A)
None
 1.14A 1hpkA-1ydfA:
undetectable		 1hpkA-1ydfA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys9 PROTEIN SPY1043

(Streptococcus
pyogenes) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ASP A 206
ASN A 207
ASP A   9
TYR A  15
 None
 1.16A 1hpkA-1ys9A:
undetectable		 1hpkA-1ys9A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY

(Enterococcus
faecalis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ASP A 208
ASN A 209
ASP A  11
TYR A  17
 None
None
PO4  A3001 (-3.0A)
None
 1.11A 1hpkA-1yv9A:
undetectable		 1hpkA-1yv9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ASP A 702
ASN A 733
ASP A 703
TYR A 656
 None
 0.96A 1hpkA-1z68A:
undetectable		 1hpkA-1z68A:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5y APOPTOSIS REGULATOR
CED-9

(Caenorhabditis
elegans) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 ASN A  71
ASP A  72
TRP A 221
TYR A 168
 None
 1.34A 1hpkA-2a5yA:
undetectable		 1hpkA-2a5yA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aao CALCIUM-DEPENDENT
PROTEIN KINASE,
ISOFORM AK1

(Arabidopsis
thaliana) 		PF13499
(EF-hand_7) 		4 ASP A 145
ASN A 146
ASP A 143
TYR A 115
 CA  A 296 (-2.9A)
None
CA  A 296 (-3.0A)
None
 1.44A 1hpkA-2aaoA:
undetectable		 1hpkA-2aaoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 PRO A 104
ASN A 128
ASP A 132
TYR A  64
 None
 1.21A 1hpkA-2bs9A:
undetectable		 1hpkA-2bs9A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		4 PRO A 214
ASP A 250
ASN A 252
TYR A 212
 None
 1.49A 1hpkA-2etvA:
undetectable		 1hpkA-2etvA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h7a HYPOTHETICAL PROTEIN
YCGL

(Escherichia
coli) 		PF05166
(YcgL) 		4 PRO A  51
ASP A  36
ASP A  35
TYR A  19
 None
 1.34A 1hpkA-2h7aA:
undetectable		 1hpkA-2h7aA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ASP A 511
ASN A 363
ASP A 364
TRP A 426
 None
 1.35A 1hpkA-2hnzA:
undetectable		 1hpkA-2hnzA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j42 C2 TOXIN
COMPONENT-II

(Clostridium
botulinum) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 PRO A 237
ASN A 378
TRP A 476
TYR A 479
 None
 1.29A 1hpkA-2j42A:
undetectable		 1hpkA-2j42A:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzj CYANOVIRIN-N HOMOLOG

(Ceratopteris
richardii) 		PF08881
(CVNH) 		4 PRO A  51
ASP A  44
ASN A  45
TYR A  50
 None
 1.41A 1hpkA-2jzjA:
undetectable		 1hpkA-2jzjA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Pseudomonas sp.
101) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 PRO A 320
ASP A 289
ASN A 266
ASP A 267
 None
 1.32A 1hpkA-2nadA:
undetectable		 1hpkA-2nadA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 PRO A 542
ASP A 500
ASP A 503
TRP A 504
 None
 1.43A 1hpkA-2qvwA:
undetectable		 1hpkA-2qvwA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdt LEVANSUCRASE

(Bacillus
subtilis) 		PF02435
(Glyco_hydro_68) 		4 ASP A 339
ASN A 242
ASP A 241
TYR A 271
 CA  A1473 (-2.4A)
None
CA  A1473 (-2.6A)
None
 1.07A 1hpkA-2vdtA:
undetectable		 1hpkA-2vdtA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PRO A 128
ASP A 278
ASN A 280
ASP A 281
 None
 1.31A 1hpkA-2vpqA:
undetectable		 1hpkA-2vpqA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 PRO A 317
ASP A 313
ASP A 311
TYR A 335
 None
NGT  A1565 (-3.4A)
None
None
 1.20A 1hpkA-2wk2A:
undetectable		 1hpkA-2wk2A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE

(Streptococcus
pneumoniae) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		4 PRO A 377
ASP A 337
ASN A 340
ASP A 341
 None
 1.35A 1hpkA-2wwdA:
undetectable		 1hpkA-2wwdA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 ASP A   8
ASN A  38
ASP A  36
TYR A  15
 None
 1.29A 1hpkA-2xkrA:
undetectable		 1hpkA-2xkrA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv5 YJEQ PROTEIN

(Aquifex
aeolicus) 		PF03193
(RsgA_GTPase) 		4 PRO A 113
ASN A 101
ASP A 100
TYR A 143
 None
 1.25A 1hpkA-2yv5A:
undetectable		 1hpkA-2yv5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2x TK-SUBTILISIN

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 PRO A  82
ASP A 315
ASP A 119
TYR A 317
 None
CA  A1007 (-2.9A)
CA  A1007 (-2.3A)
None
 1.31A 1hpkA-2z2xA:
undetectable		 1hpkA-2z2xA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		4 ASP A  81
ASN A  99
ASP A 224
TRP A 223
 None
 1.33A 1hpkA-3b8bA:
undetectable		 1hpkA-3b8bA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b98 PROSTAGLANDIN I2
SYNTHASE

(Danio rerio) 		PF00067
(p450) 		4 PRO A  29
ASP A  62
ASP A  78
TYR A 355
 None
 1.48A 1hpkA-3b98A:
undetectable		 1hpkA-3b98A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 PRO A 317
ASP A 313
ASP A 311
TYR A 336
 None
 1.02A 1hpkA-3b9eA:
undetectable		 1hpkA-3b9eA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxv SULFUR
OXYGENASE/REDUCTASE

(Acidianus
tengchongensis) 		PF07682
(SOR) 		4 PRO A   2
ASP A  82
ASP A  85
TYR A 305
 None
 1.46A 1hpkA-3bxvA:
undetectable		 1hpkA-3bxvA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 ASN A 367
ASP A 368
TRP A 377
TYR A 336
 None
 1.37A 1hpkA-3clwA:
undetectable		 1hpkA-3clwA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT

(Mus musculus) 		PF00503
(G-alpha) 		4 ASP A 179
ASN A 180
TRP A 153
TYR A 162
 None
 1.49A 1hpkA-3cx6A:
undetectable		 1hpkA-3cx6A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cym UNCHARACTERIZED
PROTEIN BAD_0989

(Bifidobacterium
adolescentis) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 PRO A 158
ASN A 165
ASP A 162
TRP A 163
 None
 1.40A 1hpkA-3cymA:
undetectable		 1hpkA-3cymA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
agalactiae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ASP A 207
ASN A 208
ASP A  11
TYR A  17
 NA  A 266 (-2.6A)
GOL  A 265 (-3.6A)
NA  A 266 (-2.7A)
None
 1.07A 1hpkA-3eprA:
undetectable		 1hpkA-3eprA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		4 PRO A 211
ASP A 145
ASP A 143
TYR A 104
 None
 1.39A 1hpkA-3focA:
undetectable		 1hpkA-3focA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION

(Saccharomyces
cerevisiae) 		PF10291
(muHD) 		4 PRO A 688
ASP A 843
ASN A 845
TYR A 642
 None
 1.32A 1hpkA-3g9hA:
undetectable		 1hpkA-3g9hA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gn3 PUTATIVE
PROTEIN-DISULFIDE
ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13462
(Thioredoxin_4) 		4 PRO A 153
ASP A 169
ASP A 177
TRP A 174
 SO4  A 180 (-4.2A)
None
None
None
 1.28A 1hpkA-3gn3A:
undetectable		 1hpkA-3gn3A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 PRO A 380
ASN A  25
ASP A  24
TRP A  23
 None
 1.42A 1hpkA-3hhdA:
undetectable		 1hpkA-3hhdA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1

(Pseudomonas
aeruginosa) 		PF05567
(Neisseria_PilC) 		4 PRO A 789
ASP A 865
ASN A 869
TYR A 809
 None
 1.20A 1hpkA-3hx6A:
undetectable		 1hpkA-3hx6A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 PRO A 243
ASP A 239
ASN A 237
ASP A 260
 None
 1.48A 1hpkA-3jurA:
undetectable		 1hpkA-3jurA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		4 PRO A  13
ASN A 233
TRP A 230
TYR A 271
 None
 1.20A 1hpkA-3k1tA:
undetectable		 1hpkA-3k1tA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6b BETA-AMYLOID-LIKE
PROTEIN

(Caenorhabditis
elegans) 		PF12925
(APP_E2) 		4 PRO A 237
ASP A 250
ASN A 246
ASP A 249
 None
None
NT2  A 501 (-4.2A)
None
 1.12A 1hpkA-3k6bA:
undetectable		 1hpkA-3k6bA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE

(Mesorhizobium
loti) 		PF12697
(Abhydrolase_6) 		4 PRO A  75
ASP A  83
ASN A  82
ASP A  86
 None
 1.17A 1hpkA-3kxpA:
undetectable		 1hpkA-3kxpA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljn HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 PRO A 272
ASN A 238
ASP A 237
TYR A 245
 None
 1.33A 1hpkA-3ljnA:
undetectable		 1hpkA-3ljnA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmz PUTATIVE SUGAR
ISOMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 ASP A 169
ASN A 196
ASP A 193
TYR A 207
 None
 1.37A 1hpkA-3lmzA:
undetectable		 1hpkA-3lmzA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1

(Homo sapiens) 		PF01369
(Sec7) 		4 PRO A 713
ASP A 754
ASN A 755
ASP A 756
 None
 1.42A 1hpkA-3ltlA:
undetectable		 1hpkA-3ltlA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n92 ALPHA-AMYLASE, GH57
FAMILY

(Thermococcus
kodakarensis) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 PRO A 149
ASP A 412
ASN A 410
TYR A 147
 None
 1.40A 1hpkA-3n92A:
undetectable		 1hpkA-3n92A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 ASN A 651
ASP A 650
TRP A 662
TYR A 572
 None
 1.34A 1hpkA-3ne5A:
undetectable		 1hpkA-3ne5A:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 PRO B 736
ASN B 727
TRP B 791
TYR B 830
 None
 1.40A 1hpkA-3p8cB:
undetectable		 1hpkA-3p8cB:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2n CYTIDINE DEAMINASE

(Mycobacterium
leprae) 		PF00383
(dCMP_cyt_deam_1) 		4 ASP A  84
ASN A  82
ASP A  80
TYR A  77
 None
 1.47A 1hpkA-3r2nA:
undetectable		 1hpkA-3r2nA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE

(Campylobacter
jejuni) 		PF00709
(Adenylsucc_synt) 		4 PRO A 362
ASP A 278
ASP A 282
TYR A 364
 None
None
PGE  A 422 ( 4.9A)
None
 1.47A 1hpkA-3r7tA:
undetectable		 1hpkA-3r7tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg0 CALRETICULIN

(Mus musculus) 		PF00262
(Calreticulin) 		4 PRO A 204
ASP A 302
ASN A 304
TYR A 299
 None
 1.45A 1hpkA-3rg0A:
undetectable		 1hpkA-3rg0A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		4 ASP A 228
ASN A 230
ASP A 229
TYR A 225
 None
 1.33A 1hpkA-3riqA:
undetectable		 1hpkA-3riqA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		4 PRO A 366
ASP A 339
ASN A 341
ASP A 343
 None
 1.45A 1hpkA-3td9A:
undetectable		 1hpkA-3td9A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 PRO A 104
ASP A 125
TRP A 172
TYR A 105
 None
 1.50A 1hpkA-3vsvA:
undetectable		 1hpkA-3vsvA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 PRO A 343
ASP A 497
ASP A 494
TYR A 614
 None
 1.29A 1hpkA-3w6qA:
undetectable		 1hpkA-3w6qA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 ASP A  11
ASN A  41
ASP A  39
TYR A  18
 None
 1.28A 1hpkA-3zbyA:
undetectable		 1hpkA-3zbyA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asm BETA-AGARASE D

(Zobellia
galactanivorans) 		no annotation 4 PRO B 300
ASP B 198
ASN B 200
TYR B 194
 None
 1.39A 1hpkA-4asmB:
undetectable		 1hpkA-4asmB:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 ASP A 183
ASN A 186
ASP A 184
TYR A 296
 None
 1.38A 1hpkA-4c2xA:
undetectable		 1hpkA-4c2xA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		4 ASP A  85
ASN A  88
ASP A  94
TYR A  33
 None
 1.45A 1hpkA-4d2iA:
undetectable		 1hpkA-4d2iA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2c DYP2

(Amycolatopsis
sp. ATCC 39116) 		no annotation 4 PRO A 290
ASP A 306
ASN A 215
ASP A 216
 ACT  A 504 ( 4.9A)
None
None
ACT  A 506 (-3.4A)
 1.33A 1hpkA-4g2cA:
undetectable		 1hpkA-4g2cA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 PRO A 233
ASP A 214
ASN A 199
TYR A 182
 None
 1.18A 1hpkA-4gq1A:
undetectable		 1hpkA-4gq1A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Saccharomyces
cerevisiae) 		PF10156
(Med17) 		4 PRO Q 544
ASN Q 534
ASP Q 536
TYR Q 640
 None
 1.35A 1hpkA-4h62Q:
undetectable		 1hpkA-4h62Q:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 PRO A  28
ASP A  59
ASN A 128
TYR A  91
 None
 1.36A 1hpkA-4jklA:
undetectable		 1hpkA-4jklA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 PRO A 169
ASP A 333
ASP A 330
TYR A 170
 None
 1.28A 1hpkA-4jzaA:
undetectable		 1hpkA-4jzaA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 PRO A 345
ASP A 416
ASN A 420
ASP A 418
 None
 1.43A 1hpkA-4na3A:
undetectable		 1hpkA-4na3A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		4 PRO A 193
ASP A 189
ASN A 207
TYR A 198
 None
 1.26A 1hpkA-4nz5A:
undetectable		 1hpkA-4nz5A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 PRO A 220
ASN A 523
ASP A 522
TRP A 528
 None
 1.45A 1hpkA-4pfwA:
undetectable		 1hpkA-4pfwA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 PRO A 232
ASP A  72
ASP A  74
TYR A  63
 None
 1.43A 1hpkA-4qanA:
undetectable		 1hpkA-4qanA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r37 PUTATIVE
ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Bacteroides
fragilis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 PRO A 176
ASP A 142
ASN A 124
TYR A 241
 None
 1.24A 1hpkA-4r37A:
undetectable		 1hpkA-4r37A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PRO A1687
ASP A1741
ASN A2067
ASP A2071
 None
MG  A4402 ( 2.3A)
AOV  A4401 ( 4.8A)
AOV  A4401 ( 3.1A)
 1.29A 1hpkA-4rh7A:
undetectable		 1hpkA-4rh7A:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF00722
(Glyco_hydro_16) 		4 PRO A 228
ASP A  27
ASP A  38
TRP A  42
 None
 1.33A 1hpkA-4xdqA:
undetectable		 1hpkA-4xdqA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 PRO A 270
ASN A 104
ASP A 170
TYR A 174
 None
 1.38A 1hpkA-4xixA:
undetectable		 1hpkA-4xixA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvs DONOR 45 01DG5 COREE
GP120
VRC07_1995
45-VRC01.H01+07.O-86
3513/45-VRC01.L01+07
.O-110653 HEAVY
CHAIN

(Homo sapiens;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF07654
(C1-set)
PF07686
(V-set) 		4 PRO H  33
ASP G 279
ASN G 276
TRP H 110
 None
 1.44A 1hpkA-4xvsH:
undetectable		 1hpkA-4xvsH:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)

(Mycobacterium
avium) 		PF00722
(Glyco_hydro_16) 		4 PRO A 244
ASP A  51
ASP A  62
TRP A  66
 None
 1.39A 1hpkA-4xxpA:
undetectable		 1hpkA-4xxpA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		4 PRO A 518
ASP A 514
ASN A  82
TYR A  35
 None
EDO  A1572 ( 4.7A)
None
None
 1.31A 1hpkA-5a29A:
undetectable		 1hpkA-5a29A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		4 PRO A 105
ASP A 333
ASP A 335
TRP A 336
 None
None
None
BGC  A1368 (-3.8A)
 1.50A 1hpkA-5a8qA:
undetectable		 1hpkA-5a8qA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 PRO A 279
ASP A 276
ASN A 253
TRP A 275
 None
 1.24A 1hpkA-5e9aA:
undetectable		 1hpkA-5e9aA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A 481
ASP A 474
ASP A 476
TYR A 444
 None
 1.21A 1hpkA-5kyvA:
undetectable		 1hpkA-5kyvA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 4 PRO A 586
ASP A 498
ASN A 519
TRP A 500
 None
 1.22A 1hpkA-5m11A:
undetectable		 1hpkA-5m11A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		4 ASP A 385
ASP A 387
TRP A 389
TYR A 115
 None
 1.48A 1hpkA-5mqsA:
undetectable		 1hpkA-5mqsA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 PRO A1212
ASP A1147
ASN A1144
TYR A1229
 None
 1.48A 1hpkA-5n0cA:
undetectable		 1hpkA-5n0cA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ASP A 668
ASN A 699
ASP A 669
TYR A 625
 None
None
None
GOL  A 801 (-4.5A)
 0.99A 1hpkA-5oljA:
undetectable		 1hpkA-5oljA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 4 PRO A 265
ASP A 315
TRP A 296
TYR A 381
 None
None
PG4  A 405 (-3.8A)
None
 1.40A 1hpkA-5utiA:
undetectable		 1hpkA-5utiA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3

(Homo sapiens) 		no annotation 4 PRO A 424
ASP A 481
ASP A 485
TRP A 482
 None
 1.39A 1hpkA-5uvgA:
undetectable		 1hpkA-5uvgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
pombe) 		no annotation 4 ASP A  85
ASN A  84
TRP A  51
TYR A  88
 None
 1.44A 1hpkA-5wjcA:
undetectable		 1hpkA-5wjcA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn7 PUTATIVE RTX-TOXIN

(Vibrio
vulnificus) 		PF11647
(MLD) 		4 PRO A2439
ASP A2498
ASN A2500
ASP A2502
 None
 1.45A 1hpkA-5xn7A:
undetectable		 1hpkA-5xn7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnr ALYQ

(Persicobacter
sp. CCB-QB2) 		no annotation 4 ASP A 447
ASN A 463
ASP A 446
TYR A 541
 None
 1.24A 1hpkA-5xnrA:
undetectable		 1hpkA-5xnrA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 4 PRO A 236
ASP A 241
ASN A 243
ASP A 242
 None
 1.47A 1hpkA-5xwqA:
undetectable		 1hpkA-5xwqA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 4 PRO A 353
ASP A 395
ASN A 399
ASP A 397
 None
 1.41A 1hpkA-6cxhA:
undetectable		 1hpkA-6cxhA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 PRO A1136
ASP A1157
ASN A   5
ASP A1159
 None
 1.44A 1hpkA-6en4A:
undetectable		 1hpkA-6en4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 PRO A 546
ASP A 469
ASN A 403
TYR A 544
 None
 1.02A 1hpkA-6f8zA:
undetectable		 1hpkA-6f8zA:
20.69